#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9GZX6 uniprotkb:Q8N6P7 intact:EBI-8040250|intact:MINT-6693924|ensembl:ENSP00000329384|ensembl:ENSP00000442424 intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800 psi-mi:il22_human(display_long)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:Cytokine Zcyto18(gene name synonym) psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Bleicher et al. (2008) pubmed:18675809|imex:IM-9583|mint:MINT-6693914|doi:10.1016/j.febslet.2008.07.046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8040288|mint:MINT-6693956|imex:IM-9583-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065386.1|dip:DIP-46035N|ensembl:ENSG00000127318(gene)|ensembl:ENST00000328087(transcript)|ensembl:ENST00000538666(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0045518"(interleukin-22 receptor binding)|go:"GO:0051384"(response to glucocorticoid)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020453|mint:Q9GZX6|rcsb pdb:1M4R|rcsb pdb:1YKB|rcsb pdb:3DGC|rcsb pdb:3DLQ|rcsb pdb:3G9V|rcsb pdb:3Q1S|reactome:R-HSA-8854691|mint:MINT-6693959(identity) ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N|mint:MINT-6693958(identity) - function:Cytokine that contributes to the inflammatory response in vivo|comment:mint - figure legend:T1 F2 F3A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/07/15 2014/10/16 rogid:yeLvTpHRMJWT0niv9ttASw0PkZU9606 rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606 intact-crc:200B3A84CA25BB15|rigid:hx2W4qi0OQ2XZRWjyu/ZDlGfAnQ false binding-associated region:29-179(MINT-6694035) binding-associated region:18-228(MINT-6693990) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)