#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9HAW4	uniprotkb:Q9UM11	intact:EBI-1369377|uniprotkb:Q5VYG0|uniprotkb:Q6P6H5|uniprotkb:Q8IWI1|uniprotkb:A6NFL4|uniprotkb:Q1RMC6|uniprotkb:Q2KHM3|intact:EBI-28979386|ensembl:ENSP00000312995	intact:EBI-724997|uniprotkb:O75869|uniprotkb:Q86U66|uniprotkb:Q96NW8|uniprotkb:Q9UI96|uniprotkb:Q9ULH8|uniprotkb:Q9UM10|uniprotkb:Q9UNQ1|uniprotkb:Q9Y2T8|intact:EBI-2558941|ensembl:ENSP00000378529	psi-mi:clspn_human(display_long)|uniprotkb:CLSPN(gene name)|psi-mi:CLSPN(display_short)	psi-mi:fzr1_human(display_long)|uniprotkb:FYR(gene name synonym)|uniprotkb:FZR(gene name synonym)|uniprotkb:KIAA1242(gene name synonym)|uniprotkb:FZR1(gene name)|psi-mi:FZR1(display_short)|uniprotkb:CDH1(gene name synonym)|uniprotkb:Cdh1/Hct1 homolog(gene name synonym)|uniprotkb:CDC20-like protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bassermann et al. (2008)	imex:IM-11905|pubmed:18662541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1805220|imex:IM-11905-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001317419.1|ensembl:ENST00000251195|ensembl:ENSP00000251195|ensembl:ENSP00000312995|ensembl:ENST00000373220|ensembl:ENSP00000362317|refseq:NP_001177410.1|refseq:NP_071394.2|ensembl:ENSG00000092853(gene)|ensembl:ENST00000318121(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000217"(DNA secondary structure binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|interpro:IPR024146|mint:Q9HAW4|rcsb pdb:7AKO|reactome:R-HSA-111465|reactome:R-HSA-176187|reactome:R-HSA-5689880|reactome:R-HSA-5693607	refseq:NP_001129669.1|refseq:NP_001129670.1|refseq:NP_057347.2|ensembl:ENSG00000105325(gene)|ensembl:ENST00000395095(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q9UM11|rcsb pdb:4UI9|rcsb pdb:5L9T|rcsb pdb:5L9U|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174178|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176417|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-69656|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:XP_005259630.1|dip:DIP-38700N	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q9UM11 transfection|figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/08/28	2014/10/16	rogid:colqtYH36pqL6fhGk1RHAf8UJVU9606	rogid:ABjKu6y+1XKC9gBB/k0uV4w1sHM9606	intact-crc:E736C52DFF5EBA72|rigid:lIvLAaWQQbao4WjvtDL1pOcJa1E	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60729	uniprotkb:Q9UM11	intact:EBI-970231|ensembl:ENSP00000364389|uniprotkb:A6N5X8|uniprotkb:O43183|uniprotkb:O60730|uniprotkb:Q5JU08|uniprotkb:B1AL31|uniprotkb:B1AL32|uniprotkb:A8MQ20	intact:EBI-724997|uniprotkb:O75869|uniprotkb:Q86U66|uniprotkb:Q96NW8|uniprotkb:Q9UI96|uniprotkb:Q9ULH8|uniprotkb:Q9UM10|uniprotkb:Q9UNQ1|uniprotkb:Q9Y2T8|intact:EBI-2558941|ensembl:ENSP00000378529	psi-mi:cc14b_human(display_long)|uniprotkb:CDC14B(gene name)|psi-mi:CDC14B(display_short)|uniprotkb:CDC14 cell division cycle 14 homolog B(gene name synonym)	psi-mi:fzr1_human(display_long)|uniprotkb:FYR(gene name synonym)|uniprotkb:FZR(gene name synonym)|uniprotkb:KIAA1242(gene name synonym)|uniprotkb:FZR1(gene name)|psi-mi:FZR1(display_short)|uniprotkb:CDH1(gene name synonym)|uniprotkb:Cdh1/Hct1 homolog(gene name synonym)|uniprotkb:CDC20-like protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bassermann et al. (2008)	imex:IM-11905|pubmed:18662541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1805324|imex:IM-11905-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000081377(gene)|ensembl:ENST00000375241(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR029260|interpro:IPR044506|mint:O60729|rcsb pdb:1OHC|rcsb pdb:1OHD|rcsb pdb:1OHE|reactome:R-HSA-5687128|refseq:NP_003662.1|refseq:NP_201588.1|refseq:XP_011517460.1|refseq:NP_001070649.1|refseq:XP_016870732.1	refseq:NP_001129669.1|refseq:NP_001129670.1|refseq:NP_057347.2|ensembl:ENSG00000105325(gene)|ensembl:ENST00000395095(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q9UM11|rcsb pdb:4UI9|rcsb pdb:5L9T|rcsb pdb:5L9U|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174178|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176417|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-69656|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:XP_005259630.1|dip:DIP-38700N	go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0051319"(G2 phase)	-	-	delivery method:O60729 transfection|figure legend:Fig. 4D|agonist:Doxorubicin - a DNA damaging agent|comment:Interaction only occurs in the whole cell following DNA damage|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2008/08/28	2014/10/16	rogid:b0+v+nN2fk9Eo6xMg0SlaXHWQAA9606	rogid:ABjKu6y+1XKC9gBB/k0uV4w1sHM9606	intact-crc:7DD1AD7C7FF46941|rigid:k0Gl6fWs7D5WoCHE3lN7ILrj8gU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30260	uniprotkb:Q9UM11	intact:EBI-994813|uniprotkb:Q16349|uniprotkb:Q96F35|ensembl:ENSP00000066544|uniprotkb:G3V1C4|intact:EBI-10972530	intact:EBI-724997|uniprotkb:O75869|uniprotkb:Q86U66|uniprotkb:Q96NW8|uniprotkb:Q9UI96|uniprotkb:Q9ULH8|uniprotkb:Q9UM10|uniprotkb:Q9UNQ1|uniprotkb:Q9Y2T8|intact:EBI-2558941|ensembl:ENSP00000378529	psi-mi:cdc27_human(display_long)|uniprotkb:CDC27(gene name)|psi-mi:CDC27(display_short)|uniprotkb:D0S1430E(gene name synonym)|uniprotkb:D17S978E(gene name synonym)|uniprotkb:CDC27 homolog(gene name synonym)|uniprotkb:H-NUC(gene name synonym)|uniprotkb:ANAPC3(gene name synonym)|uniprotkb:Anaphase-promoting complex subunit 3(gene name synonym)	psi-mi:fzr1_human(display_long)|uniprotkb:FYR(gene name synonym)|uniprotkb:FZR(gene name synonym)|uniprotkb:KIAA1242(gene name synonym)|uniprotkb:FZR1(gene name)|psi-mi:FZR1(display_short)|uniprotkb:CDH1(gene name synonym)|uniprotkb:Cdh1/Hct1 homolog(gene name synonym)|uniprotkb:CDC20-like protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bassermann et al. (2008)	imex:IM-11905|pubmed:18662541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1805431|imex:IM-11905-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000004897(gene)|ensembl:ENST00000066544(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0072686"(mitotic spindle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|rcsb pdb:3T1N|go:"GO:0005680"(anaphase-promoting complex)|rcsb pdb:4RG6|rcsb pdb:4RG7|rcsb pdb:4RG9|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:NP_001107563.1|refseq:NP_001247.3|dip:DIP-36422N	refseq:NP_001129669.1|refseq:NP_001129670.1|refseq:NP_057347.2|ensembl:ENSG00000105325(gene)|ensembl:ENST00000395095(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q9UM11|rcsb pdb:4UI9|rcsb pdb:5L9T|rcsb pdb:5L9U|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174178|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176417|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-69656|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:XP_005259630.1|dip:DIP-38700N	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q9UM11 transfection|figure legend:Supp. Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2008/08/28	2015/08/14	rogid:YOrJCRal5ZfO7kP2b8FPon0Yytw9606	rogid:ABjKu6y+1XKC9gBB/k0uV4w1sHM9606	intact-crc:6CB51D5FEC39071B|rigid:2roGXrfeiMNuRzKB2yrftW/H+Og	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HAW4	uniprotkb:Q9UM11	intact:EBI-1369377|uniprotkb:Q5VYG0|uniprotkb:Q6P6H5|uniprotkb:Q8IWI1|uniprotkb:A6NFL4|uniprotkb:Q1RMC6|uniprotkb:Q2KHM3|intact:EBI-28979386|ensembl:ENSP00000312995	intact:EBI-724997|uniprotkb:O75869|uniprotkb:Q86U66|uniprotkb:Q96NW8|uniprotkb:Q9UI96|uniprotkb:Q9ULH8|uniprotkb:Q9UM10|uniprotkb:Q9UNQ1|uniprotkb:Q9Y2T8|intact:EBI-2558941|ensembl:ENSP00000378529	psi-mi:clspn_human(display_long)|uniprotkb:CLSPN(gene name)|psi-mi:CLSPN(display_short)	psi-mi:fzr1_human(display_long)|uniprotkb:FYR(gene name synonym)|uniprotkb:FZR(gene name synonym)|uniprotkb:KIAA1242(gene name synonym)|uniprotkb:FZR1(gene name)|psi-mi:FZR1(display_short)|uniprotkb:CDH1(gene name synonym)|uniprotkb:Cdh1/Hct1 homolog(gene name synonym)|uniprotkb:CDC20-like protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bassermann et al. (2008)	imex:IM-11905|pubmed:18662541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1805346|imex:IM-11905-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001317419.1|ensembl:ENST00000251195|ensembl:ENSP00000251195|ensembl:ENSP00000312995|ensembl:ENST00000373220|ensembl:ENSP00000362317|refseq:NP_001177410.1|refseq:NP_071394.2|ensembl:ENSG00000092853(gene)|ensembl:ENST00000318121(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000217"(DNA secondary structure binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|interpro:IPR024146|mint:Q9HAW4|rcsb pdb:7AKO|reactome:R-HSA-111465|reactome:R-HSA-176187|reactome:R-HSA-5689880|reactome:R-HSA-5693607	refseq:NP_001129669.1|refseq:NP_001129670.1|refseq:NP_057347.2|ensembl:ENSG00000105325(gene)|ensembl:ENST00000395095(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q9UM11|rcsb pdb:4UI9|rcsb pdb:5L9T|rcsb pdb:5L9U|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174178|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176417|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-69656|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:XP_005259630.1|dip:DIP-38700N	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q9UM11; Q9HAW4 transfection|figure legend:Fig. S2B, S2C, Supp. Fig. 2F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/08/28	2014/10/16	rogid:colqtYH36pqL6fhGk1RHAf8UJVU9606	rogid:ABjKu6y+1XKC9gBB/k0uV4w1sHM9606	intact-crc:83DAE769D205B2E1|rigid:lIvLAaWQQbao4WjvtDL1pOcJa1E	false	flag tag:?-?|sufficient binding region:79-340|mutation disrupting interaction:86-88|mutation disrupting interaction:90-92	ha tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q9HAW4	uniprotkb:Q9UM11	intact:EBI-1369377|uniprotkb:Q5VYG0|uniprotkb:Q6P6H5|uniprotkb:Q8IWI1|uniprotkb:A6NFL4|uniprotkb:Q1RMC6|uniprotkb:Q2KHM3|intact:EBI-28979386|ensembl:ENSP00000312995	intact:EBI-724997|uniprotkb:O75869|uniprotkb:Q86U66|uniprotkb:Q96NW8|uniprotkb:Q9UI96|uniprotkb:Q9ULH8|uniprotkb:Q9UM10|uniprotkb:Q9UNQ1|uniprotkb:Q9Y2T8|intact:EBI-2558941|ensembl:ENSP00000378529	psi-mi:clspn_human(display_long)|uniprotkb:CLSPN(gene name)|psi-mi:CLSPN(display_short)	psi-mi:fzr1_human(display_long)|uniprotkb:FYR(gene name synonym)|uniprotkb:FZR(gene name synonym)|uniprotkb:KIAA1242(gene name synonym)|uniprotkb:FZR1(gene name)|psi-mi:FZR1(display_short)|uniprotkb:CDH1(gene name synonym)|uniprotkb:Cdh1/Hct1 homolog(gene name synonym)|uniprotkb:CDC20-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bassermann et al. (2008)	imex:IM-11905|pubmed:18662541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1805365|imex:IM-11905-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001317419.1|ensembl:ENST00000251195|ensembl:ENSP00000251195|ensembl:ENSP00000312995|ensembl:ENST00000373220|ensembl:ENSP00000362317|refseq:NP_001177410.1|refseq:NP_071394.2|ensembl:ENSG00000092853(gene)|ensembl:ENST00000318121(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000217"(DNA secondary structure binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|interpro:IPR024146|mint:Q9HAW4|rcsb pdb:7AKO|reactome:R-HSA-111465|reactome:R-HSA-176187|reactome:R-HSA-5689880|reactome:R-HSA-5693607	refseq:NP_001129669.1|refseq:NP_001129670.1|refseq:NP_057347.2|ensembl:ENSG00000105325(gene)|ensembl:ENST00000395095(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q9UM11|rcsb pdb:4UI9|rcsb pdb:5L9T|rcsb pdb:5L9U|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174178|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176417|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-69656|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:XP_005259630.1|dip:DIP-38700N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/08/28	2014/10/16	rogid:colqtYH36pqL6fhGk1RHAf8UJVU9606	rogid:ABjKu6y+1XKC9gBB/k0uV4w1sHM9606	intact-crc:3E442D38965CC27A|rigid:lIvLAaWQQbao4WjvtDL1pOcJa1E	false	35s radiolabel:?-?|sufficient binding region:79-340	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9HAW4	uniprotkb:Q9UM11	intact:EBI-1369377|uniprotkb:Q5VYG0|uniprotkb:Q6P6H5|uniprotkb:Q8IWI1|uniprotkb:A6NFL4|uniprotkb:Q1RMC6|uniprotkb:Q2KHM3|intact:EBI-28979386|ensembl:ENSP00000312995	intact:EBI-724997|uniprotkb:O75869|uniprotkb:Q86U66|uniprotkb:Q96NW8|uniprotkb:Q9UI96|uniprotkb:Q9ULH8|uniprotkb:Q9UM10|uniprotkb:Q9UNQ1|uniprotkb:Q9Y2T8|intact:EBI-2558941|ensembl:ENSP00000378529	psi-mi:clspn_human(display_long)|uniprotkb:CLSPN(gene name)|psi-mi:CLSPN(display_short)	psi-mi:fzr1_human(display_long)|uniprotkb:FYR(gene name synonym)|uniprotkb:FZR(gene name synonym)|uniprotkb:KIAA1242(gene name synonym)|uniprotkb:FZR1(gene name)|psi-mi:FZR1(display_short)|uniprotkb:CDH1(gene name synonym)|uniprotkb:Cdh1/Hct1 homolog(gene name synonym)|uniprotkb:CDC20-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bassermann et al. (2008)	imex:IM-11905|pubmed:18662541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1805377|imex:IM-11905-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001317419.1|ensembl:ENST00000251195|ensembl:ENSP00000251195|ensembl:ENSP00000312995|ensembl:ENST00000373220|ensembl:ENSP00000362317|refseq:NP_001177410.1|refseq:NP_071394.2|ensembl:ENSG00000092853(gene)|ensembl:ENST00000318121(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000217"(DNA secondary structure binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|interpro:IPR024146|mint:Q9HAW4|rcsb pdb:7AKO|reactome:R-HSA-111465|reactome:R-HSA-176187|reactome:R-HSA-5689880|reactome:R-HSA-5693607	refseq:NP_001129669.1|refseq:NP_001129670.1|refseq:NP_057347.2|ensembl:ENSG00000105325(gene)|ensembl:ENST00000395095(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q9UM11|rcsb pdb:4UI9|rcsb pdb:5L9T|rcsb pdb:5L9U|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174178|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176417|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-69656|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:XP_005259630.1|dip:DIP-38700N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/08/28	2014/10/16	rogid:colqtYH36pqL6fhGk1RHAf8UJVU9606	rogid:ABjKu6y+1XKC9gBB/k0uV4w1sHM9606	intact-crc:D074661C651AB984|rigid:lIvLAaWQQbao4WjvtDL1pOcJa1E	false	35s radiolabel:?-?|sufficient binding region:79-102	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9UM11	uniprotkb:P30260	intact:EBI-724997|uniprotkb:O75869|uniprotkb:Q86U66|uniprotkb:Q96NW8|uniprotkb:Q9UI96|uniprotkb:Q9ULH8|uniprotkb:Q9UM10|uniprotkb:Q9UNQ1|uniprotkb:Q9Y2T8|intact:EBI-2558941|ensembl:ENSP00000378529	intact:EBI-994813|uniprotkb:Q16349|uniprotkb:Q96F35|ensembl:ENSP00000066544|uniprotkb:G3V1C4|intact:EBI-10972530	psi-mi:fzr1_human(display_long)|uniprotkb:FYR(gene name synonym)|uniprotkb:FZR(gene name synonym)|uniprotkb:KIAA1242(gene name synonym)|uniprotkb:FZR1(gene name)|psi-mi:FZR1(display_short)|uniprotkb:CDH1(gene name synonym)|uniprotkb:Cdh1/Hct1 homolog(gene name synonym)|uniprotkb:CDC20-like protein 1(gene name synonym)	psi-mi:cdc27_human(display_long)|uniprotkb:CDC27(gene name)|psi-mi:CDC27(display_short)|uniprotkb:D0S1430E(gene name synonym)|uniprotkb:D17S978E(gene name synonym)|uniprotkb:CDC27 homolog(gene name synonym)|uniprotkb:H-NUC(gene name synonym)|uniprotkb:ANAPC3(gene name synonym)|uniprotkb:Anaphase-promoting complex subunit 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bassermann et al. (2008)	imex:IM-11905|pubmed:18662541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1805405|imex:IM-11905-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129669.1|refseq:NP_001129670.1|refseq:NP_057347.2|ensembl:ENSG00000105325(gene)|ensembl:ENST00000395095(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q9UM11|rcsb pdb:4UI9|rcsb pdb:5L9T|rcsb pdb:5L9U|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174178|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176417|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-69656|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:XP_005259630.1|dip:DIP-38700N	ensembl:ENSG00000004897(gene)|ensembl:ENST00000066544(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0072686"(mitotic spindle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|rcsb pdb:3T1N|go:"GO:0005680"(anaphase-promoting complex)|rcsb pdb:4RG6|rcsb pdb:4RG7|rcsb pdb:4RG9|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:NP_001107563.1|refseq:NP_001247.3|dip:DIP-36422N	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)	-	-	agonist:"Irradiation (10Gy)"|figure legend:Supp. 4A|comment:Interaction only occurs in whole cells following irradiation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2008/08/28	2015/08/14	rogid:ABjKu6y+1XKC9gBB/k0uV4w1sHM9606	rogid:YOrJCRal5ZfO7kP2b8FPon0Yytw9606	intact-crc:BBCCBF9A2E077FA5|rigid:2roGXrfeiMNuRzKB2yrftW/H+Og	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30260	uniprotkb:Q9UM11	intact:EBI-994813|uniprotkb:Q16349|uniprotkb:Q96F35|ensembl:ENSP00000066544|uniprotkb:G3V1C4|intact:EBI-10972530	intact:EBI-724997|uniprotkb:O75869|uniprotkb:Q86U66|uniprotkb:Q96NW8|uniprotkb:Q9UI96|uniprotkb:Q9ULH8|uniprotkb:Q9UM10|uniprotkb:Q9UNQ1|uniprotkb:Q9Y2T8|intact:EBI-2558941|ensembl:ENSP00000378529	psi-mi:cdc27_human(display_long)|uniprotkb:CDC27(gene name)|psi-mi:CDC27(display_short)|uniprotkb:D0S1430E(gene name synonym)|uniprotkb:D17S978E(gene name synonym)|uniprotkb:CDC27 homolog(gene name synonym)|uniprotkb:H-NUC(gene name synonym)|uniprotkb:ANAPC3(gene name synonym)|uniprotkb:Anaphase-promoting complex subunit 3(gene name synonym)	psi-mi:fzr1_human(display_long)|uniprotkb:FYR(gene name synonym)|uniprotkb:FZR(gene name synonym)|uniprotkb:KIAA1242(gene name synonym)|uniprotkb:FZR1(gene name)|psi-mi:FZR1(display_short)|uniprotkb:CDH1(gene name synonym)|uniprotkb:Cdh1/Hct1 homolog(gene name synonym)|uniprotkb:CDC20-like protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bassermann et al. (2008)	imex:IM-11905|pubmed:18662541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1805423|imex:IM-11905-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000004897(gene)|ensembl:ENST00000066544(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0072686"(mitotic spindle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|rcsb pdb:3T1N|go:"GO:0005680"(anaphase-promoting complex)|rcsb pdb:4RG6|rcsb pdb:4RG7|rcsb pdb:4RG9|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:NP_001107563.1|refseq:NP_001247.3|dip:DIP-36422N	refseq:NP_001129669.1|refseq:NP_001129670.1|refseq:NP_057347.2|ensembl:ENSG00000105325(gene)|ensembl:ENST00000395095(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q9UM11|rcsb pdb:4UI9|rcsb pdb:5L9T|rcsb pdb:5L9U|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174178|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176417|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-69656|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:XP_005259630.1|dip:DIP-38700N	go:"GO:0051319"(G2 phase)	-	-	agonist:Doxorubicin - a DNA damaging reagent|figure legend:Supp. fig. 4B|comment:Binding of FZR1 increased following DNA damage|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2008/08/28	2015/08/14	rogid:YOrJCRal5ZfO7kP2b8FPon0Yytw9606	rogid:ABjKu6y+1XKC9gBB/k0uV4w1sHM9606	intact-crc:9D5C8561452E8874|rigid:cUqGSWXoHCjt40CJq7h8/AZRB14	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30260	uniprotkb:Q9UKT4	intact:EBI-994813|uniprotkb:Q16349|uniprotkb:Q96F35|ensembl:ENSP00000066544|uniprotkb:G3V1C4|intact:EBI-10972530	intact:EBI-852298|uniprotkb:Q8WV29|uniprotkb:Q9UGC8|uniprotkb:B3KNX5|uniprotkb:Q5TF47|ensembl:ENSP00000229758	psi-mi:cdc27_human(display_long)|uniprotkb:CDC27(gene name)|psi-mi:CDC27(display_short)|uniprotkb:D0S1430E(gene name synonym)|uniprotkb:D17S978E(gene name synonym)|uniprotkb:CDC27 homolog(gene name synonym)|uniprotkb:H-NUC(gene name synonym)|uniprotkb:ANAPC3(gene name synonym)|uniprotkb:Anaphase-promoting complex subunit 3(gene name synonym)	psi-mi:fbx5_human(display_long)|uniprotkb:FBXO5(gene name)|psi-mi:FBXO5(display_short)|uniprotkb:EMI1(gene name synonym)|uniprotkb:FBX5(gene name synonym)|uniprotkb:Early mitotic inhibitor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bassermann et al. (2008)	imex:IM-11905|pubmed:18662541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1805423|imex:IM-11905-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000004897(gene)|ensembl:ENST00000066544(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0072686"(mitotic spindle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|rcsb pdb:3T1N|go:"GO:0005680"(anaphase-promoting complex)|rcsb pdb:4RG6|rcsb pdb:4RG7|rcsb pdb:4RG9|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:NP_001107563.1|refseq:NP_001247.3|dip:DIP-36422N	refseq:NP_001135994.1|refseq:NP_036309.1|dip:DIP-38023N|ensembl:ENSG00000112029(gene)|ensembl:ENST00000229758(transcript)|go:"GO:0001556"(oocyte maturation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016050"(vesicle organization)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032876"(negative regulation of DNA endoreduplication)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0072687"(meiotic spindle)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001021"(negative regulation of response to DNA damage stimulus)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR044064|mint:Q9UKT4|rcsb pdb:2M6N|rcsb pdb:4UI9|reactome:R-HSA-174113|reactome:R-HSA-176408|reactome:R-HSA-176417|reactome:R-HSA-68881|reactome:R-HSA-69205	go:"GO:0051319"(G2 phase)	-	-	agonist:Doxorubicin - a DNA damaging reagent|figure legend:Supp. fig. 4B|comment:Binding of FZR1 increased following DNA damage|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2008/08/28	2015/08/14	rogid:YOrJCRal5ZfO7kP2b8FPon0Yytw9606	rogid:6NU7FdV1cnJsK3TuNKMdirgBhVM9606	intact-crc:9D5C8561452E8874|rigid:cUqGSWXoHCjt40CJq7h8/AZRB14	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)