#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q01094	uniprotkb:Q8NEM0	intact:EBI-448924|uniprotkb:Q13143|uniprotkb:Q92768|ensembl:ENSP00000345571	intact:EBI-1565483|uniprotkb:Q66GU1|uniprotkb:Q9H9C7|uniprotkb:A0A075B6F8|uniprotkb:B4DWW2|uniprotkb:E9PH63|uniprotkb:E9PGU5|ensembl:ENSP00000342924|ensembl:ENSP00000493874	psi-mi:e2f1_human(display_long)|uniprotkb:Retinoblastoma-associated protein 1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 3(gene name synonym)|uniprotkb:PBR3(gene name synonym)|uniprotkb:E2F1(gene name)|psi-mi:E2F1(display_short)|uniprotkb:RBBP3(gene name synonym)|uniprotkb:pRB-binding protein E2F-1(gene name synonym)	psi-mi:mcph1_human(display_long)|uniprotkb:MCPH1(gene name)|psi-mi:MCPH1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yang et al. (2008)	pubmed:18660752|imex:IM-9693|mint:MINT-6804843|doi:10.1038/embor.2008.128	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8035032|mint:MINT-6804850|imex:IM-9693-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005216.1|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048255"(mRNA stabilization)|ensembl:ENSG00000101412(gene)|ensembl:ENST00000343380(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804116|reactome:R-HSA-68689|reactome:R-HSA-68911|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q01094|rcsb pdb:1H24|rcsb pdb:1O9K|rcsb pdb:2AZE|rcsb pdb:5M9N|rcsb pdb:5M9O|rcsb pdb:6G0P|rcsb pdb:6ULS|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9616222|reactome:R-HSA-9661069|dip:DIP-24227N|mint:MINT-6804853(identity)	refseq:NP_001166045.1|refseq:NP_001166046.1|refseq:NP_078872.2|refseq:NP_001308971.1|refseq:NP_001308972.1|refseq:NP_001308974.1|dip:DIP-39802N|ensembl:ENSG00000147316(gene)|ensembl:ENSG00000285262(gene)|ensembl:ENST00000344683(transcript)|ensembl:ENST00000647051(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060348"(bone development)|go:"GO:0060623"(regulation of chromosome condensation)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR001357(BRCT)|interpro:IPR022047|interpro:IPR029504|interpro:IPR036420|mint:Q8NEM0|rcsb pdb:2WT8|rcsb pdb:3KTF|rcsb pdb:3PA6|rcsb pdb:3SHT|rcsb pdb:3SHV|rcsb pdb:3SZM|rcsb pdb:3T1N|rcsb pdb:3U3Z|rcsb pdb:7C5D|reactome:R-HSA-2299718|mint:MINT-6804852(identity)	-	-	crc64:D17961B94EC240A3	figure legend:f1a|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/12/16	2017/05/26	rogid:vPNenpmxyXpHjMzUID54cwMFk+Y9606	rogid:EL5tbrvv9UfYCOmG+7yweFO2zH49606	intact-crc:C6A67D9ED4056A60|rigid:ovKAnhWRsoiMvtY7Eei4Dw6jock	false	-	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q8NEM0	uniprotkb:Q01094	intact:EBI-1565483|uniprotkb:Q66GU1|uniprotkb:Q9H9C7|uniprotkb:A0A075B6F8|uniprotkb:B4DWW2|uniprotkb:E9PH63|uniprotkb:E9PGU5|ensembl:ENSP00000342924|ensembl:ENSP00000493874	intact:EBI-448924|uniprotkb:Q13143|uniprotkb:Q92768|ensembl:ENSP00000345571	psi-mi:mcph1_human(display_long)|uniprotkb:MCPH1(gene name)|psi-mi:MCPH1(display_short)	psi-mi:e2f1_human(display_long)|uniprotkb:Retinoblastoma-associated protein 1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 3(gene name synonym)|uniprotkb:PBR3(gene name synonym)|uniprotkb:E2F1(gene name)|psi-mi:E2F1(display_short)|uniprotkb:RBBP3(gene name synonym)|uniprotkb:pRB-binding protein E2F-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yang et al. (2008)	pubmed:18660752|imex:IM-9693|mint:MINT-6804843|doi:10.1038/embor.2008.128	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8035045|mint:MINT-6804865|imex:IM-9693-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166045.1|refseq:NP_001166046.1|refseq:NP_078872.2|refseq:NP_001308971.1|refseq:NP_001308972.1|refseq:NP_001308974.1|dip:DIP-39802N|ensembl:ENSG00000147316(gene)|ensembl:ENSG00000285262(gene)|ensembl:ENST00000344683(transcript)|ensembl:ENST00000647051(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060348"(bone development)|go:"GO:0060623"(regulation of chromosome condensation)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR001357(BRCT)|interpro:IPR022047|interpro:IPR029504|interpro:IPR036420|mint:Q8NEM0|rcsb pdb:2WT8|rcsb pdb:3KTF|rcsb pdb:3PA6|rcsb pdb:3SHT|rcsb pdb:3SHV|rcsb pdb:3SZM|rcsb pdb:3T1N|rcsb pdb:3U3Z|rcsb pdb:7C5D|reactome:R-HSA-2299718|mint:MINT-6804869(identity)	refseq:NP_005216.1|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048255"(mRNA stabilization)|ensembl:ENSG00000101412(gene)|ensembl:ENST00000343380(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804116|reactome:R-HSA-68689|reactome:R-HSA-68911|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q01094|rcsb pdb:1H24|rcsb pdb:1O9K|rcsb pdb:2AZE|rcsb pdb:5M9N|rcsb pdb:5M9O|rcsb pdb:6G0P|rcsb pdb:6ULS|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9616222|reactome:R-HSA-9661069|dip:DIP-24227N|mint:MINT-6804867(identity)	-	crc64:D17961B94EC240A3	-	figure legend:f1b|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/12/16	2017/05/26	rogid:EL5tbrvv9UfYCOmG+7yweFO2zH49606	rogid:vPNenpmxyXpHjMzUID54cwMFk+Y9606	intact-crc:940B96BA7EC6FAF9|rigid:ovKAnhWRsoiMvtY7Eei4Dw6jock	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q14209	uniprotkb:Q8NEM0	intact:EBI-718476|uniprotkb:Q7Z6H1|uniprotkb:B2R9W1|ensembl:ENSP00000355249|ensembl:ENSP00000489612	intact:EBI-1565483|uniprotkb:Q66GU1|uniprotkb:Q9H9C7|uniprotkb:A0A075B6F8|uniprotkb:B4DWW2|uniprotkb:E9PH63|uniprotkb:E9PGU5|ensembl:ENSP00000342924|ensembl:ENSP00000493874	psi-mi:e2f2_human(display_long)|uniprotkb:E2F2(gene name)|psi-mi:E2F2(display_short)	psi-mi:mcph1_human(display_long)|uniprotkb:MCPH1(gene name)|psi-mi:MCPH1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yang et al. (2008)	pubmed:18660752|imex:IM-9693|mint:MINT-6804843|doi:10.1038/embor.2008.128	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8035122|mint:MINT-6804894|imex:IM-9693-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004082.1|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q14209|rcsb pdb:1N4M|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-68689|reactome:R-HSA-69231|reactome:R-HSA-9661069|ensembl:ENSG00000007968(gene)|ensembl:ENSG00000282899(gene)|ensembl:ENST00000361729(transcript)|ensembl:ENST00000634683(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-258N|mint:MINT-6804903(identity)	refseq:NP_001166045.1|refseq:NP_001166046.1|refseq:NP_078872.2|refseq:NP_001308971.1|refseq:NP_001308972.1|refseq:NP_001308974.1|dip:DIP-39802N|ensembl:ENSG00000147316(gene)|ensembl:ENSG00000285262(gene)|ensembl:ENST00000344683(transcript)|ensembl:ENST00000647051(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060348"(bone development)|go:"GO:0060623"(regulation of chromosome condensation)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR001357(BRCT)|interpro:IPR022047|interpro:IPR029504|interpro:IPR036420|mint:Q8NEM0|rcsb pdb:2WT8|rcsb pdb:3KTF|rcsb pdb:3PA6|rcsb pdb:3SHT|rcsb pdb:3SHV|rcsb pdb:3SZM|rcsb pdb:3T1N|rcsb pdb:3U3Z|rcsb pdb:7C5D|reactome:R-HSA-2299718|mint:MINT-6804896(identity)	-	-	crc64:D17961B94EC240A3	figure legend:f1e|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/12/16	2017/05/26	rogid:mTyyEcashAWBpjb0viYJv5OiREY9606	rogid:EL5tbrvv9UfYCOmG+7yweFO2zH49606	intact-crc:D26EAD4F6426B03E|rigid:WLnApvjMOi4MaVlscIk7z8XDUkE	false	-	myc tag:?-?(MINT-6804900)|binding-associated region:640-833(MINT-6804897)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q8NEM0	uniprotkb:Q01094	intact:EBI-1565483|uniprotkb:Q66GU1|uniprotkb:Q9H9C7|uniprotkb:A0A075B6F8|uniprotkb:B4DWW2|uniprotkb:E9PH63|uniprotkb:E9PGU5|ensembl:ENSP00000342924|ensembl:ENSP00000493874	intact:EBI-448924|uniprotkb:Q13143|uniprotkb:Q92768|ensembl:ENSP00000345571	psi-mi:mcph1_human(display_long)|uniprotkb:MCPH1(gene name)|psi-mi:MCPH1(display_short)	psi-mi:e2f1_human(display_long)|uniprotkb:Retinoblastoma-associated protein 1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 3(gene name synonym)|uniprotkb:PBR3(gene name synonym)|uniprotkb:E2F1(gene name)|psi-mi:E2F1(display_short)|uniprotkb:RBBP3(gene name synonym)|uniprotkb:pRB-binding protein E2F-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yang et al. (2008)	pubmed:18660752|imex:IM-9693|mint:MINT-6804843|doi:10.1038/embor.2008.128	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8035101|mint:MINT-6804878|imex:IM-9693-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166045.1|refseq:NP_001166046.1|refseq:NP_078872.2|refseq:NP_001308971.1|refseq:NP_001308972.1|refseq:NP_001308974.1|dip:DIP-39802N|ensembl:ENSG00000147316(gene)|ensembl:ENSG00000285262(gene)|ensembl:ENST00000344683(transcript)|ensembl:ENST00000647051(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060348"(bone development)|go:"GO:0060623"(regulation of chromosome condensation)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR001357(BRCT)|interpro:IPR022047|interpro:IPR029504|interpro:IPR036420|mint:Q8NEM0|rcsb pdb:2WT8|rcsb pdb:3KTF|rcsb pdb:3PA6|rcsb pdb:3SHT|rcsb pdb:3SHV|rcsb pdb:3SZM|rcsb pdb:3T1N|rcsb pdb:3U3Z|rcsb pdb:7C5D|reactome:R-HSA-2299718|mint:MINT-6804882(identity)	refseq:NP_005216.1|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048255"(mRNA stabilization)|ensembl:ENSG00000101412(gene)|ensembl:ENST00000343380(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804116|reactome:R-HSA-68689|reactome:R-HSA-68911|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q01094|rcsb pdb:1H24|rcsb pdb:1O9K|rcsb pdb:2AZE|rcsb pdb:5M9N|rcsb pdb:5M9O|rcsb pdb:6G0P|rcsb pdb:6ULS|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9616222|reactome:R-HSA-9661069|dip:DIP-24227N|mint:MINT-6804880(identity)	-	crc64:D17961B94EC240A3	-	figure legend:f1d|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/12/16	2017/05/26	rogid:EL5tbrvv9UfYCOmG+7yweFO2zH49606	rogid:vPNenpmxyXpHjMzUID54cwMFk+Y9606	intact-crc:50AA35F7136C4F93|rigid:ovKAnhWRsoiMvtY7Eei4Dw6jock	false	myc tag:?-?(MINT-6804887)|binding-associated region:640-833(MINT-6804889)	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q8NEM0	uniprotkb:Q01094	intact:EBI-1565483|uniprotkb:Q66GU1|uniprotkb:Q9H9C7|uniprotkb:A0A075B6F8|uniprotkb:B4DWW2|uniprotkb:E9PH63|uniprotkb:E9PGU5|ensembl:ENSP00000342924|ensembl:ENSP00000493874	intact:EBI-448924|uniprotkb:Q13143|uniprotkb:Q92768|ensembl:ENSP00000345571	psi-mi:mcph1_human(display_long)|uniprotkb:MCPH1(gene name)|psi-mi:MCPH1(display_short)	psi-mi:e2f1_human(display_long)|uniprotkb:Retinoblastoma-associated protein 1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 3(gene name synonym)|uniprotkb:PBR3(gene name synonym)|uniprotkb:E2F1(gene name)|psi-mi:E2F1(display_short)|uniprotkb:RBBP3(gene name synonym)|uniprotkb:pRB-binding protein E2F-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yang et al. (2008)	pubmed:18660752|imex:IM-9693|mint:MINT-6804843|doi:10.1038/embor.2008.128	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8035166|mint:MINT-6804968|imex:IM-9693-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166045.1|refseq:NP_001166046.1|refseq:NP_078872.2|refseq:NP_001308971.1|refseq:NP_001308972.1|refseq:NP_001308974.1|dip:DIP-39802N|ensembl:ENSG00000147316(gene)|ensembl:ENSG00000285262(gene)|ensembl:ENST00000344683(transcript)|ensembl:ENST00000647051(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060348"(bone development)|go:"GO:0060623"(regulation of chromosome condensation)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR001357(BRCT)|interpro:IPR022047|interpro:IPR029504|interpro:IPR036420|mint:Q8NEM0|rcsb pdb:2WT8|rcsb pdb:3KTF|rcsb pdb:3PA6|rcsb pdb:3SHT|rcsb pdb:3SHV|rcsb pdb:3SZM|rcsb pdb:3T1N|rcsb pdb:3U3Z|rcsb pdb:7C5D|reactome:R-HSA-2299718|mint:MINT-6804970(identity)	refseq:NP_005216.1|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048255"(mRNA stabilization)|ensembl:ENSG00000101412(gene)|ensembl:ENST00000343380(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804116|reactome:R-HSA-68689|reactome:R-HSA-68911|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q01094|rcsb pdb:1H24|rcsb pdb:1O9K|rcsb pdb:2AZE|rcsb pdb:5M9N|rcsb pdb:5M9O|rcsb pdb:6G0P|rcsb pdb:6ULS|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9616222|reactome:R-HSA-9661069|dip:DIP-24227N|mint:MINT-6804977(identity)	-	crc64:D17961B94EC240A3	-	figure legend:f5f|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/12/16	2017/05/26	rogid:EL5tbrvv9UfYCOmG+7yweFO2zH49606	rogid:vPNenpmxyXpHjMzUID54cwMFk+Y9606	intact-crc:73A2093E499989B7|rigid:ovKAnhWRsoiMvtY7Eei4Dw6jock	false	flag tag:?-?(MINT-6804974)	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q8NEM0	uniprotkb:Q8NEM0	intact:EBI-1565483|uniprotkb:Q66GU1|uniprotkb:Q9H9C7|uniprotkb:A0A075B6F8|uniprotkb:B4DWW2|uniprotkb:E9PH63|uniprotkb:E9PGU5|ensembl:ENSP00000342924|ensembl:ENSP00000493874	intact:EBI-1565483|uniprotkb:Q66GU1|uniprotkb:Q9H9C7|uniprotkb:A0A075B6F8|uniprotkb:B4DWW2|uniprotkb:E9PH63|uniprotkb:E9PGU5|ensembl:ENSP00000342924|ensembl:ENSP00000493874	psi-mi:mcph1_human(display_long)|uniprotkb:MCPH1(gene name)|psi-mi:MCPH1(display_short)	psi-mi:mcph1_human(display_long)|uniprotkb:MCPH1(gene name)|psi-mi:MCPH1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yang et al. (2008)	pubmed:18660752|imex:IM-9693|mint:MINT-6804843|doi:10.1038/embor.2008.128	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8035143|mint:MINT-6804949|imex:IM-9693-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166045.1|refseq:NP_001166046.1|refseq:NP_078872.2|refseq:NP_001308971.1|refseq:NP_001308972.1|refseq:NP_001308974.1|dip:DIP-39802N|ensembl:ENSG00000147316(gene)|ensembl:ENSG00000285262(gene)|ensembl:ENST00000344683(transcript)|ensembl:ENST00000647051(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060348"(bone development)|go:"GO:0060623"(regulation of chromosome condensation)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR001357(BRCT)|interpro:IPR022047|interpro:IPR029504|interpro:IPR036420|mint:Q8NEM0|rcsb pdb:2WT8|rcsb pdb:3KTF|rcsb pdb:3PA6|rcsb pdb:3SHT|rcsb pdb:3SHV|rcsb pdb:3SZM|rcsb pdb:3T1N|rcsb pdb:3U3Z|rcsb pdb:7C5D|reactome:R-HSA-2299718|mint:MINT-6804955(identity)	refseq:NP_001166045.1|refseq:NP_001166046.1|refseq:NP_078872.2|refseq:NP_001308971.1|refseq:NP_001308972.1|refseq:NP_001308974.1|dip:DIP-39802N|ensembl:ENSG00000147316(gene)|ensembl:ENSG00000285262(gene)|ensembl:ENST00000344683(transcript)|ensembl:ENST00000647051(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060348"(bone development)|go:"GO:0060623"(regulation of chromosome condensation)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR001357(BRCT)|interpro:IPR022047|interpro:IPR029504|interpro:IPR036420|mint:Q8NEM0|rcsb pdb:2WT8|rcsb pdb:3KTF|rcsb pdb:3PA6|rcsb pdb:3SHT|rcsb pdb:3SHV|rcsb pdb:3SZM|rcsb pdb:3T1N|rcsb pdb:3U3Z|rcsb pdb:7C5D|reactome:R-HSA-2299718|mint:MINT-6804951(identity)	-	crc64:D17961B94EC240A3	crc64:D17961B94EC240A3	comment:homomint|figure legend:sf5a|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/12/16	2017/05/26	rogid:EL5tbrvv9UfYCOmG+7yweFO2zH49606	rogid:EL5tbrvv9UfYCOmG+7yweFO2zH49606	intact-crc:7A25C5BCAD84C986|rigid:Dmh7eIKBOZLau2zcYm0dPJEZRL8	false	flag tag:?-?(MINT-6804956)	myc tag:?-?(MINT-6804952)|binding-associated region:640-833(MINT-6804962)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8NEM0	uniprotkb:Q01094	intact:EBI-1565483|uniprotkb:Q66GU1|uniprotkb:Q9H9C7|uniprotkb:A0A075B6F8|uniprotkb:B4DWW2|uniprotkb:E9PH63|uniprotkb:E9PGU5|ensembl:ENSP00000342924|ensembl:ENSP00000493874	intact:EBI-448924|uniprotkb:Q13143|uniprotkb:Q92768|ensembl:ENSP00000345571	psi-mi:mcph1_human(display_long)|uniprotkb:MCPH1(gene name)|psi-mi:MCPH1(display_short)	psi-mi:e2f1_human(display_long)|uniprotkb:Retinoblastoma-associated protein 1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 3(gene name synonym)|uniprotkb:PBR3(gene name synonym)|uniprotkb:E2F1(gene name)|psi-mi:E2F1(display_short)|uniprotkb:RBBP3(gene name synonym)|uniprotkb:pRB-binding protein E2F-1(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Yang et al. (2008)	pubmed:18660752|imex:IM-9693|mint:MINT-6804843|doi:10.1038/embor.2008.128	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8035273|mint:MINT-6804908|imex:IM-9693-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166045.1|refseq:NP_001166046.1|refseq:NP_078872.2|refseq:NP_001308971.1|refseq:NP_001308972.1|refseq:NP_001308974.1|dip:DIP-39802N|ensembl:ENSG00000147316(gene)|ensembl:ENSG00000285262(gene)|ensembl:ENST00000344683(transcript)|ensembl:ENST00000647051(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060348"(bone development)|go:"GO:0060623"(regulation of chromosome condensation)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR001357(BRCT)|interpro:IPR022047|interpro:IPR029504|interpro:IPR036420|mint:Q8NEM0|rcsb pdb:2WT8|rcsb pdb:3KTF|rcsb pdb:3PA6|rcsb pdb:3SHT|rcsb pdb:3SHV|rcsb pdb:3SZM|rcsb pdb:3T1N|rcsb pdb:3U3Z|rcsb pdb:7C5D|reactome:R-HSA-2299718|mint:MINT-6804910(identity)	refseq:NP_005216.1|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048255"(mRNA stabilization)|ensembl:ENSG00000101412(gene)|ensembl:ENST00000343380(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804116|reactome:R-HSA-68689|reactome:R-HSA-68911|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q01094|rcsb pdb:1H24|rcsb pdb:1O9K|rcsb pdb:2AZE|rcsb pdb:5M9N|rcsb pdb:5M9O|rcsb pdb:6G0P|rcsb pdb:6ULS|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9616222|reactome:R-HSA-9661069|dip:DIP-24227N|mint:MINT-6804917(identity)	-	crc64:D17961B94EC240A3	-	comment:homomint|figure legend:f1g f1h|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/12/16	2017/05/26	rogid:EL5tbrvv9UfYCOmG+7yweFO2zH49606	rogid:vPNenpmxyXpHjMzUID54cwMFk+Y9606	intact-crc:CFD095D325C7A207|rigid:ovKAnhWRsoiMvtY7Eei4Dw6jock	false	yellow fluorescent protein tag:?-?(MINT-6804914)	yellow fluorescent protein tag:?-?(MINT-6804925)|binding-associated region:1-150(MINT-6804927)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEM0	uniprotkb:Q8NEM0	intact:EBI-1565483|uniprotkb:Q66GU1|uniprotkb:Q9H9C7|uniprotkb:A0A075B6F8|uniprotkb:B4DWW2|uniprotkb:E9PH63|uniprotkb:E9PGU5|ensembl:ENSP00000342924|ensembl:ENSP00000493874	intact:EBI-1565483|uniprotkb:Q66GU1|uniprotkb:Q9H9C7|uniprotkb:A0A075B6F8|uniprotkb:B4DWW2|uniprotkb:E9PH63|uniprotkb:E9PGU5|ensembl:ENSP00000342924|ensembl:ENSP00000493874	psi-mi:mcph1_human(display_long)|uniprotkb:MCPH1(gene name)|psi-mi:MCPH1(display_short)	psi-mi:mcph1_human(display_long)|uniprotkb:MCPH1(gene name)|psi-mi:MCPH1(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Yang et al. (2008)	pubmed:18660752|imex:IM-9693|mint:MINT-6804843|doi:10.1038/embor.2008.128	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8035296|mint:MINT-6804932|imex:IM-9693-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166045.1|refseq:NP_001166046.1|refseq:NP_078872.2|refseq:NP_001308971.1|refseq:NP_001308972.1|refseq:NP_001308974.1|dip:DIP-39802N|ensembl:ENSG00000147316(gene)|ensembl:ENSG00000285262(gene)|ensembl:ENST00000344683(transcript)|ensembl:ENST00000647051(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060348"(bone development)|go:"GO:0060623"(regulation of chromosome condensation)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR001357(BRCT)|interpro:IPR022047|interpro:IPR029504|interpro:IPR036420|mint:Q8NEM0|rcsb pdb:2WT8|rcsb pdb:3KTF|rcsb pdb:3PA6|rcsb pdb:3SHT|rcsb pdb:3SHV|rcsb pdb:3SZM|rcsb pdb:3T1N|rcsb pdb:3U3Z|rcsb pdb:7C5D|reactome:R-HSA-2299718|mint:MINT-6804940(identity)	refseq:NP_001166045.1|refseq:NP_001166046.1|refseq:NP_078872.2|refseq:NP_001308971.1|refseq:NP_001308972.1|refseq:NP_001308974.1|dip:DIP-39802N|ensembl:ENSG00000147316(gene)|ensembl:ENSG00000285262(gene)|ensembl:ENST00000344683(transcript)|ensembl:ENST00000647051(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060348"(bone development)|go:"GO:0060623"(regulation of chromosome condensation)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR001357(BRCT)|interpro:IPR022047|interpro:IPR029504|interpro:IPR036420|mint:Q8NEM0|rcsb pdb:2WT8|rcsb pdb:3KTF|rcsb pdb:3PA6|rcsb pdb:3SHT|rcsb pdb:3SHV|rcsb pdb:3SZM|rcsb pdb:3T1N|rcsb pdb:3U3Z|rcsb pdb:7C5D|reactome:R-HSA-2299718|mint:MINT-6804934(identity)	-	crc64:D17961B94EC240A3	crc64:D17961B94EC240A3	figure legend:f5c|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/12/16	2017/05/26	rogid:EL5tbrvv9UfYCOmG+7yweFO2zH49606	rogid:EL5tbrvv9UfYCOmG+7yweFO2zH49606	intact-crc:10E60C21F19F9703|rigid:Dmh7eIKBOZLau2zcYm0dPJEZRL8	false	yellow fluorescent protein tag:?-?(MINT-6804941)	yellow fluorescent protein tag:?-?(MINT-6804937)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q01094	uniprotkb:Q8NEM0	intact:EBI-448924|uniprotkb:Q13143|uniprotkb:Q92768|ensembl:ENSP00000345571	intact:EBI-1565483|uniprotkb:Q66GU1|uniprotkb:Q9H9C7|uniprotkb:A0A075B6F8|uniprotkb:B4DWW2|uniprotkb:E9PH63|uniprotkb:E9PGU5|ensembl:ENSP00000342924|ensembl:ENSP00000493874	psi-mi:e2f1_human(display_long)|uniprotkb:Retinoblastoma-associated protein 1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 3(gene name synonym)|uniprotkb:PBR3(gene name synonym)|uniprotkb:E2F1(gene name)|psi-mi:E2F1(display_short)|uniprotkb:RBBP3(gene name synonym)|uniprotkb:pRB-binding protein E2F-1(gene name synonym)	psi-mi:mcph1_human(display_long)|uniprotkb:MCPH1(gene name)|psi-mi:MCPH1(display_short)	psi-mi:"MI:0096"(pull down)	Yang et al. (2008)	pubmed:18660752|imex:IM-9693|mint:MINT-6804843|doi:10.1038/embor.2008.128	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8035323|mint:MINT-6804982|imex:IM-9693-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005216.1|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048255"(mRNA stabilization)|ensembl:ENSG00000101412(gene)|ensembl:ENST00000343380(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804116|reactome:R-HSA-68689|reactome:R-HSA-68911|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q01094|rcsb pdb:1H24|rcsb pdb:1O9K|rcsb pdb:2AZE|rcsb pdb:5M9N|rcsb pdb:5M9O|rcsb pdb:6G0P|rcsb pdb:6ULS|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9616222|reactome:R-HSA-9661069|dip:DIP-24227N|mint:MINT-6804984(identity)	refseq:NP_001166045.1|refseq:NP_001166046.1|refseq:NP_078872.2|refseq:NP_001308971.1|refseq:NP_001308972.1|refseq:NP_001308974.1|dip:DIP-39802N|ensembl:ENSG00000147316(gene)|ensembl:ENSG00000285262(gene)|ensembl:ENST00000344683(transcript)|ensembl:ENST00000647051(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060348"(bone development)|go:"GO:0060623"(regulation of chromosome condensation)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR001357(BRCT)|interpro:IPR022047|interpro:IPR029504|interpro:IPR036420|mint:Q8NEM0|rcsb pdb:2WT8|rcsb pdb:3KTF|rcsb pdb:3PA6|rcsb pdb:3SHT|rcsb pdb:3SHV|rcsb pdb:3SZM|rcsb pdb:3T1N|rcsb pdb:3U3Z|rcsb pdb:7C5D|reactome:R-HSA-2299718|mint:MINT-6804986(identity)	-	-	crc64:D17961B94EC240A3	comment:homomint|figure legend:sf1|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/12/16	2017/05/26	rogid:vPNenpmxyXpHjMzUID54cwMFk+Y9606	rogid:EL5tbrvv9UfYCOmG+7yweFO2zH49606	intact-crc:6D79D9869E76D8A5|rigid:ovKAnhWRsoiMvtY7Eei4Dw6jock	false	-	glutathione s tranferase tag:?-?(MINT-6804987)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)