#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O14933 uniprotkb:P21605 intact:EBI-2129974|uniprotkb:A6NDM6|uniprotkb:Q8N5D8|uniprotkb:A8MY53|uniprotkb:Q9UEZ0|ensembl:ENSP00000287156 intact:EBI-6149107|uniprotkb:Q76ZW2 psi-mi:ub2l6_human(display_long)|uniprotkb:UBE2L6(gene name)|psi-mi:UBE2L6(display_short)|uniprotkb:UBCH8(gene name synonym)|uniprotkb:Ubiquitin-protein ligase L6(gene name synonym)|uniprotkb:Ubiquitin carrier protein L6(gene name synonym)|uniprotkb:UbcH8(gene name synonym)|uniprotkb:Retinoic acid-induced gene B protein(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme L6(gene name synonym) psi-mi:e3_vaccw(display_long)|uniprotkb:p25(gene name synonym)|uniprotkb:E3L(orf name)|uniprotkb:VACWR059(locus name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Guerra et al. (2008) pubmed:18604270|mint:MINT-6735148 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8009816|mint:MINT-6741176 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004214.1|refseq:NP_937826.1|ensembl:ENSP00000287156|ensembl:ENST00000340573|ensembl:ENSP00000341980|dip:DIP-41477N|ensembl:ENSG00000156587(gene)|go:"GO:0042296"(ISG15 transferase activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:O14933|rcsb pdb:1WZV|rcsb pdb:1WZW|rcsb pdb:2KJH|reactome:R-HSA-1169408|reactome:R-HSA-168928|reactome:R-HSA-5656169|ensembl:ENST00000287156(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|reactome:R-HSA-936440|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|mint:MINT-6741177(identity)|uniprotkb:O14933(O14933) mint:P21605|refseq:YP_232941.1|dip:DIP-2175N|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003726"(double-stranded RNA adenosine deaminase activity)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039580"(suppression by virus of host PKR signaling)|interpro:IPR009179(Interferon resistance/PKR inhibitor, vaccinia E3L type)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036388|interpro:IPR036390|interpro:IPR042371|mint:MINT-6741179(identity)|uniprotkb:P21605(P21605) - - - figure legend:F5|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-3(unknown)|taxid:-3(Unknown) - 2008/07/28 2014/10/16 rogid:18K+ReSJfSpKRvnLuED+kPB3beY9606 rogid:DYwGRaSIXZHFPvGmcXzSaPkG9s010254 intact-crc:318744D184F4E958|rigid:mKuD7U27vT6MGZilxgx/sJTlAJo false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14933 uniprotkb:P21605 intact:EBI-2129974|uniprotkb:A6NDM6|uniprotkb:Q8N5D8|uniprotkb:A8MY53|uniprotkb:Q9UEZ0|ensembl:ENSP00000287156 intact:EBI-6149107|uniprotkb:Q76ZW2 psi-mi:ub2l6_human(display_long)|uniprotkb:UBE2L6(gene name)|psi-mi:UBE2L6(display_short)|uniprotkb:UBCH8(gene name synonym)|uniprotkb:Ubiquitin-protein ligase L6(gene name synonym)|uniprotkb:Ubiquitin carrier protein L6(gene name synonym)|uniprotkb:UbcH8(gene name synonym)|uniprotkb:Retinoic acid-induced gene B protein(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme L6(gene name synonym) psi-mi:e3_vaccw(display_long)|uniprotkb:p25(gene name synonym)|uniprotkb:E3L(orf name)|uniprotkb:VACWR059(locus name) psi-mi:"MI:0416"(fluorescence microscopy) Guerra et al. (2008) pubmed:18604270|mint:MINT-6735148 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8009859|mint:MINT-6741183 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004214.1|refseq:NP_937826.1|ensembl:ENSP00000287156|ensembl:ENST00000340573|ensembl:ENSP00000341980|dip:DIP-41477N|ensembl:ENSG00000156587(gene)|go:"GO:0042296"(ISG15 transferase activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:O14933|rcsb pdb:1WZV|rcsb pdb:1WZW|rcsb pdb:2KJH|reactome:R-HSA-1169408|reactome:R-HSA-168928|reactome:R-HSA-5656169|ensembl:ENST00000287156(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|reactome:R-HSA-936440|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|mint:MINT-6741186(identity)|uniprotkb:O14933(O14933) mint:P21605|refseq:YP_232941.1|dip:DIP-2175N|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003726"(double-stranded RNA adenosine deaminase activity)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039580"(suppression by virus of host PKR signaling)|interpro:IPR009179(Interferon resistance/PKR inhibitor, vaccinia E3L type)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036388|interpro:IPR036390|interpro:IPR042371|mint:MINT-6741184(identity)|uniprotkb:P21605(P21605) - - - figure legend:F5|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-3(unknown)|taxid:-3(Unknown) - 2008/07/28 2014/10/16 rogid:18K+ReSJfSpKRvnLuED+kPB3beY9606 rogid:DYwGRaSIXZHFPvGmcXzSaPkG9s010254 intact-crc:9DE90659F006C8B4|rigid:mKuD7U27vT6MGZilxgx/sJTlAJo false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)