#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q96EK4 uniprotkb:P70677 intact:EBI-1790529|uniprotkb:O94795|uniprotkb:A8K002|uniprotkb:A4UCT5|ensembl:ENSP00000304689 intact:EBI-1790419|uniprotkb:O08668|uniprotkb:Q8CHV5|uniprotkb:Q9QWI4|ensembl:ENSMUSP00000091238|ensembl:ENSMUSP00000147767 psi-mi:tha11_human(display_long)|uniprotkb:THAP11(gene name)|psi-mi:THAP11(display_short)|uniprotkb:HRIHFB2206(orf name) psi-mi:casp3_mouse(display_long)|uniprotkb:Casp3(gene name)|psi-mi:Casp3(display_short)|uniprotkb:Cpp32(gene name synonym)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:LICE(gene name synonym) psi-mi:"MI:0018"(two hybrid) Dejosez et al. (2008) imex:IM-11926|pubmed:18585351 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1790455|imex:IM-11926-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065190.2|dip:DIP-46732N|ensembl:ENSP00000304689|ensembl:ENSG00000168286(gene)|ensembl:ENST00000303596(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006612(Zinc finger, C2CH-type)|rcsb pdb:2LAU|rcsb pdb:5AJS refseq:NP_001271338.1|dip:DIP-44076N|refseq:NP_033940.1|refseq:XP_017168032.1|ensembl:ENSMUSG00000031628(gene)|ensembl:ENSMUST00000093517(transcript)|ensembl:ENSMUST00000211115(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0010033"(response to organic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P70677|reactome:R-MMU-111459|reactome:R-MMU-111465|reactome:R-MMU-111469|reactome:R-MMU-140342|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-264870|reactome:R-MMU-351906|reactome:R-MMU-418889|reactome:R-MMU-449836|reactome:R-MMU-5620971 psi-mi:"MI:0469"(intact) crc64:25235D20CB54D8C2 - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2008/07/10 2014/10/16 rogid:qzl6RN2xlTuDBruwyKLyDTNRCKE9606 rogid:tSqWk4T+WiXomdMHEk4xthh9MZs10090 intact-crc:DE80BE319631287E|rigid:11ROnYMfCRyE61wpSRAu2iq/KrM false - mutation:163-163 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9JJD0 ensembl:ENSMUSG00000021944 intact:EBI-1790697|uniprotkb:Q3TCZ5|uniprotkb:Q99KZ0|ensembl:ENSMUSP00000048994 intact:EBI-1790676 psi-mi:tha11_mouse(display_long)|uniprotkb:Thap11(gene name)|psi-mi:Thap11(display_short)|uniprotkb:MNCb-2032(orf name)|uniprotkb:Ronin(gene name synonym) psi-mi:gata4_mouse_gene(display_short)|psi-mi:ENSMUSG00000021944(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Dejosez et al. (2008) imex:IM-11926|pubmed:18585351 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1790710|imex:IM-11926-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_067488.1|ensembl:ENSMUSG00000036442(gene)|ensembl:ENSMUST00000040445(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006612(Zinc finger, C2CH-type) - go:"GO:0003677"(DNA binding) - - comment:Trap11 binds to the 3x promoter region of this gene, Histone H3 is methylated.|figure legend:Fig. 6E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2008/07/10 2014/10/16 rogid:TT0etvKgUG6sjJynaW1sm0YrdlM10090 - intact-crc:4DD1A7581A26E113 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) ensembl:ENSMUSG00000005836 uniprotkb:Q9JJD0 intact:EBI-1790678 intact:EBI-1790697|uniprotkb:Q3TCZ5|uniprotkb:Q99KZ0|ensembl:ENSMUSP00000048994 psi-mi:gata6_mouse_gene(display_short)|psi-mi:ENSMUSG00000005836(display_long) psi-mi:tha11_mouse(display_long)|uniprotkb:Thap11(gene name)|psi-mi:Thap11(display_short)|uniprotkb:MNCb-2032(orf name)|uniprotkb:Ronin(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Dejosez et al. (2008) imex:IM-11926|pubmed:18585351 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1790717|imex:IM-11926-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) - refseq:NP_067488.1|ensembl:ENSMUSG00000036442(gene)|ensembl:ENSMUST00000040445(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006612(Zinc finger, C2CH-type) go:"GO:0003677"(DNA binding) - - comment:Trap11 binds to the 3x promoter region of this gene, Histone H3 is methylated.|figure legend:Fig. 6E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2008/07/10 2014/10/16 - rogid:TT0etvKgUG6sjJynaW1sm0YrdlM10090 intact-crc:ABF53C6D2CE7DA31 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) ensembl:ENSMUSG00000024406 uniprotkb:Q9JJD0 intact:EBI-1790693 intact:EBI-1790697|uniprotkb:Q3TCZ5|uniprotkb:Q99KZ0|ensembl:ENSMUSP00000048994 psi-mi:oct4_mouse_gene(display_short)|psi-mi:ENSMUSG00000024406(display_long) psi-mi:tha11_mouse(display_long)|uniprotkb:Thap11(gene name)|psi-mi:Thap11(display_short)|uniprotkb:MNCb-2032(orf name)|uniprotkb:Ronin(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Dejosez et al. (2008) imex:IM-11926|pubmed:18585351 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1790775|imex:IM-11926-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) - refseq:NP_067488.1|ensembl:ENSMUSG00000036442(gene)|ensembl:ENSMUST00000040445(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006612(Zinc finger, C2CH-type) go:"GO:0003677"(DNA binding) - - comment:Trap11 binds to the 3x promoter region of this gene, but only in differentiated ES cells|figure legend:Fig. 6E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2008/07/10 2014/10/16 - rogid:TT0etvKgUG6sjJynaW1sm0YrdlM10090 intact-crc:439C810CD4C3F49F false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P51610 uniprotkb:Q96EK4 intact:EBI-396176|intact:EBI-2832627|uniprotkb:Q6P4G5|intact:EBI-12037257|intact:EBI-14324845|ensembl:ENSP00000309555|intact:EBI-12980473 intact:EBI-1790529|uniprotkb:O94795|uniprotkb:A8K002|uniprotkb:A4UCT5|ensembl:ENSP00000304689 psi-mi:hcfc1_human(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short)|uniprotkb:HCF1(gene name synonym)|uniprotkb:C1 factor(gene name synonym)|uniprotkb:VP16 accessory protein(gene name synonym)|uniprotkb:VCAF(gene name synonym)|uniprotkb:CFF(gene name synonym)|uniprotkb:HFC1(gene name synonym) psi-mi:tha11_human(display_long)|uniprotkb:THAP11(gene name)|psi-mi:THAP11(display_short)|uniprotkb:HRIHFB2206(orf name) psi-mi:"MI:0018"(two hybrid) Dejosez et al. (2008) imex:IM-11926|pubmed:18585351 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1790937|imex:IM-11926-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005325.2|refseq:XP_006724879.1|rcsb pdb:6MA1|rcsb pdb:6MA2|rcsb pdb:6MA3|rcsb pdb:6MA4|rcsb pdb:6MA5|reactome:R-HSA-2151201|reactome:R-HSA-3214847|reactome:R-HSA-5689603|ensembl:ENSG00000172534(gene)|ensembl:ENST00000310441(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019046"(release from viral latency)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR036116|interpro:IPR037854|interpro:IPR043536|mint:P51610|rcsb pdb:4GO6|rcsb pdb:4N39|rcsb pdb:4N3A|rcsb pdb:4N3B|rcsb pdb:4N3C|rcsb pdb:5LWV|dip:DIP-32955N refseq:NP_065190.2|dip:DIP-46732N|ensembl:ENSP00000304689|ensembl:ENSG00000168286(gene)|ensembl:ENST00000303596(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006612(Zinc finger, C2CH-type)|rcsb pdb:2LAU|rcsb pdb:5AJS psi-mi:"MI:0469"(intact) - crc64:25235D20CB54D8C2 figure legend:Fig. 7A|caution:Human THAP11 is only 313 amino acids long as desribed in UniProtKB, not 315 as given in the paper|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2008/07/10 2014/10/16 rogid:RzsCRe9l6md3DI87H4ZgdR9oBMI9606 rogid:qzl6RN2xlTuDBruwyKLyDTNRCKE9606 intact-crc:98970E6565451CCD|rigid:ettcVVY+U5akhtgdRdkHFqfebHo false sufficient binding region:1-429 sufficient binding region:133-314 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96EK4 uniprotkb:P51610 intact:EBI-1790529|uniprotkb:O94795|uniprotkb:A8K002|uniprotkb:A4UCT5|ensembl:ENSP00000304689 intact:EBI-396176|intact:EBI-2832627|uniprotkb:Q6P4G5|intact:EBI-12037257|intact:EBI-14324845|ensembl:ENSP00000309555|intact:EBI-12980473 psi-mi:tha11_human(display_long)|uniprotkb:THAP11(gene name)|psi-mi:THAP11(display_short)|uniprotkb:HRIHFB2206(orf name) psi-mi:hcfc1_human(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short)|uniprotkb:HCF1(gene name synonym)|uniprotkb:C1 factor(gene name synonym)|uniprotkb:VP16 accessory protein(gene name synonym)|uniprotkb:VCAF(gene name synonym)|uniprotkb:CFF(gene name synonym)|uniprotkb:HFC1(gene name synonym) psi-mi:"MI:0096"(pull down) Dejosez et al. (2008) imex:IM-11926|pubmed:18585351 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1790971|imex:IM-11926-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065190.2|dip:DIP-46732N|ensembl:ENSP00000304689|ensembl:ENSG00000168286(gene)|ensembl:ENST00000303596(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006612(Zinc finger, C2CH-type)|rcsb pdb:2LAU|rcsb pdb:5AJS refseq:NP_005325.2|refseq:XP_006724879.1|rcsb pdb:6MA1|rcsb pdb:6MA2|rcsb pdb:6MA3|rcsb pdb:6MA4|rcsb pdb:6MA5|reactome:R-HSA-2151201|reactome:R-HSA-3214847|reactome:R-HSA-5689603|ensembl:ENSG00000172534(gene)|ensembl:ENST00000310441(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019046"(release from viral latency)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR036116|interpro:IPR037854|interpro:IPR043536|mint:P51610|rcsb pdb:4GO6|rcsb pdb:4N39|rcsb pdb:4N3A|rcsb pdb:4N3B|rcsb pdb:4N3C|rcsb pdb:5LWV|dip:DIP-32955N psi-mi:"MI:0469"(intact) crc64:25235D20CB54D8C2 - figure legend:Fig. 7D|delivery method:P51610; Q96EK4 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2008/07/10 2014/10/16 rogid:qzl6RN2xlTuDBruwyKLyDTNRCKE9606 rogid:RzsCRe9l6md3DI87H4ZgdR9oBMI9606 intact-crc:0DAFE00EC54B6D26|rigid:ettcVVY+U5akhtgdRdkHFqfebHo false sufficient binding region:133-314|glutathione s tranferase tag:?-? sufficient binding region:1-429|myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96EK4 uniprotkb:Q96EK4 intact:EBI-1790529|uniprotkb:O94795|uniprotkb:A8K002|uniprotkb:A4UCT5|ensembl:ENSP00000304689 intact:EBI-1790529|uniprotkb:O94795|uniprotkb:A8K002|uniprotkb:A4UCT5|ensembl:ENSP00000304689 psi-mi:tha11_human(display_long)|uniprotkb:THAP11(gene name)|psi-mi:THAP11(display_short)|uniprotkb:HRIHFB2206(orf name) psi-mi:tha11_human(display_long)|uniprotkb:THAP11(gene name)|psi-mi:THAP11(display_short)|uniprotkb:HRIHFB2206(orf name) psi-mi:"MI:0096"(pull down) Dejosez et al. (2008) imex:IM-11926|pubmed:18585351 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1791269|imex:IM-11926-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065190.2|dip:DIP-46732N|ensembl:ENSP00000304689|ensembl:ENSG00000168286(gene)|ensembl:ENST00000303596(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006612(Zinc finger, C2CH-type)|rcsb pdb:2LAU|rcsb pdb:5AJS refseq:NP_065190.2|dip:DIP-46732N|ensembl:ENSP00000304689|ensembl:ENSG00000168286(gene)|ensembl:ENST00000303596(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006612(Zinc finger, C2CH-type)|rcsb pdb:2LAU|rcsb pdb:5AJS psi-mi:"MI:0469"(intact) crc64:25235D20CB54D8C2 crc64:25235D20CB54D8C2 figure legend:Fig. 7D|delivery method:Q96EK4 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2008/07/10 2014/10/16 rogid:qzl6RN2xlTuDBruwyKLyDTNRCKE9606 rogid:qzl6RN2xlTuDBruwyKLyDTNRCKE9606 intact-crc:0B28F2756500410B|rigid:ncRhfKA+oa+WGNOnV22Rd6bhBn0 false sufficient binding region:133-314|glutathione s tranferase tag:?-? sufficient binding region:133-314|myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96ST3 uniprotkb:Q96EK4 intact:EBI-347218|uniprotkb:Q8N8N4|uniprotkb:Q8NC83|uniprotkb:Q8WV18|uniprotkb:Q96L98|uniprotkb:Q9UFQ1|intact:EBI-28985143|ensembl:ENSP00000353622|ensembl:ENSP00000378402|ensembl:ENSP00000378403|uniprotkb:B2RNS5 intact:EBI-1790529|uniprotkb:O94795|uniprotkb:A8K002|uniprotkb:A4UCT5|ensembl:ENSP00000304689 psi-mi:sin3a_human(display_long)|uniprotkb:SIN3A(gene name)|psi-mi:SIN3A(display_short)|uniprotkb:Transcriptional corepressor Sin3a(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3a(gene name synonym) psi-mi:tha11_human(display_long)|uniprotkb:THAP11(gene name)|psi-mi:THAP11(display_short)|uniprotkb:HRIHFB2206(orf name) psi-mi:"MI:0096"(pull down) Dejosez et al. (2008) imex:IM-11926|pubmed:18585351 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1791309|imex:IM-11926-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006720528.1|ensembl:ENSG00000169375(gene)|ensembl:ENST00000360439(transcript)|ensembl:ENST00000394947(transcript)|ensembl:ENST00000394949(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007568"(aging)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031937"(obsolete positive regulation of chromatin silencing)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0051595"(response to methylglyoxal)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901675"(negative regulation of histone H3-K27 acetylation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR037969|interpro:IPR039774|mint:Q96ST3|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-427413|reactome:R-HSA-8936459|reactome:R-HSA-9022538|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|rcsb pdb:1PO4|reactome:R-HSA-9615017|reactome:R-HSA-9707564|reactome:R-HSA-983231|refseq:XP_006720529.1|refseq:XP_006720530.1|refseq:NP_001138829.1|refseq:NP_001138830.1|refseq:NP_056292.1|ensembl:ENSP00000353622|ensembl:ENSP00000378402|ensembl:ENSP00000378403|dip:DIP-31515N refseq:NP_065190.2|dip:DIP-46732N|ensembl:ENSP00000304689|ensembl:ENSG00000168286(gene)|ensembl:ENST00000303596(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006612(Zinc finger, C2CH-type)|rcsb pdb:2LAU|rcsb pdb:5AJS psi-mi:"MI:0469"(intact) - crc64:25235D20CB54D8C2 figure legend:Fig. 7D|delivery method:Q96EK4; Q96ST3 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2008/07/10 2014/10/16 rogid:pO/FziDcMNQRfy6ePi6eNKELXVM9606 rogid:qzl6RN2xlTuDBruwyKLyDTNRCKE9606 intact-crc:D40E7A1FA35AEE20|rigid:yUPa5oHsuJKxmlEvUUychm1nMRI false sufficient binding region:1-123|myc tag:?-? sufficient binding region:133-314|glutathione s tranferase tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96EK4 uniprotkb:Q9BT49 intact:EBI-1790529|uniprotkb:O94795|uniprotkb:A8K002|uniprotkb:A4UCT5|ensembl:ENSP00000304689 intact:EBI-741350|ensembl:ENSP00000215742|ensembl:ENSP00000382084|uniprotkb:B2RD97|uniprotkb:D3DX40 psi-mi:tha11_human(display_long)|uniprotkb:THAP11(gene name)|psi-mi:THAP11(display_short)|uniprotkb:HRIHFB2206(orf name) psi-mi:thap7_human(display_long)|uniprotkb:THAP7(gene name)|psi-mi:THAP7(display_short) psi-mi:"MI:0096"(pull down) Dejosez et al. (2008) imex:IM-11926|pubmed:18585351 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1791320|imex:IM-11926-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065190.2|dip:DIP-46732N|ensembl:ENSP00000304689|ensembl:ENSG00000168286(gene)|ensembl:ENST00000303596(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006612(Zinc finger, C2CH-type)|rcsb pdb:2LAU|rcsb pdb:5AJS refseq:NP_001008695.1|refseq:NP_085050.2|ensembl:ENSG00000184436(gene)|ensembl:ENST00000215742(transcript)|ensembl:ENST00000399133(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016607"(nuclear speck)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0106153"(phosphorylated histone binding)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR006612(Zinc finger, C2CH-type)|interpro:IPR026519 psi-mi:"MI:0469"(intact) crc64:25235D20CB54D8C2 - figure legend:Fig. 7D|delivery method:Q9BT49; Q96EK4 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2008/07/10 2014/10/16 rogid:qzl6RN2xlTuDBruwyKLyDTNRCKE9606 rogid:4efYWbkvlRsynamdao3y6gVxhtA9606 intact-crc:5EFFBF64D88F8D32|rigid:XZ7Gmdo3fCu6n8rqrGTT8sqYMPs false sufficient binding region:1-103(IPR006612)|glutathione s tranferase tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96EK4 uniprotkb:O15379 intact:EBI-1790529|uniprotkb:O94795|uniprotkb:A8K002|uniprotkb:A4UCT5|ensembl:ENSP00000304689 intact:EBI-607682|uniprotkb:O43268|uniprotkb:Q9UEI5|uniprotkb:Q9UEV0|uniprotkb:D3DQE1|ensembl:ENSP00000302967 psi-mi:tha11_human(display_long)|uniprotkb:THAP11(gene name)|psi-mi:THAP11(display_short)|uniprotkb:HRIHFB2206(orf name) psi-mi:hdac3_human(display_long)|uniprotkb:HDAC3(gene name)|psi-mi:HDAC3(display_short)|uniprotkb:RPD3-2(gene name synonym)|uniprotkb:SMAP45(gene name synonym) psi-mi:"MI:0096"(pull down) Dejosez et al. (2008) imex:IM-11926|pubmed:18585351 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1791332|imex:IM-11926-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065190.2|dip:DIP-46732N|ensembl:ENSP00000304689|ensembl:ENSG00000168286(gene)|ensembl:ENST00000303596(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006612(Zinc finger, C2CH-type)|rcsb pdb:2LAU|rcsb pdb:5AJS refseq:NP_003874.2|dip:DIP-24253N|ensembl:ENSG00000171720(gene)|ensembl:ENST00000305264(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O15379|rcsb pdb:4A69|reactome:R-HSA-1368071|reactome:R-HSA-193670|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-390471|reactome:R-HSA-400206|reactome:R-HSA-5617472|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-400253 psi-mi:"MI:0469"(intact) crc64:25235D20CB54D8C2 - figure legend:Fig. 7D|delivery method:O15379; Q96EK4 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2008/07/10 2014/10/16 rogid:qzl6RN2xlTuDBruwyKLyDTNRCKE9606 rogid:X5pnE98s15eXKev3nauN7ri5kqg9606 intact-crc:C98B0A1343D0E080|rigid:THG/rTNB8ARALRkBfSA1uQhCZTY false sufficient binding region:1-103(IPR006612)|glutathione s tranferase tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P70677 uniprotkb:Q96EK4 intact:EBI-1790419|uniprotkb:O08668|uniprotkb:Q8CHV5|uniprotkb:Q9QWI4|ensembl:ENSMUSP00000091238|ensembl:ENSMUSP00000147767 intact:EBI-1790529|uniprotkb:O94795|uniprotkb:A8K002|uniprotkb:A4UCT5|ensembl:ENSP00000304689 psi-mi:casp3_mouse(display_long)|uniprotkb:Casp3(gene name)|psi-mi:Casp3(display_short)|uniprotkb:Cpp32(gene name synonym)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:LICE(gene name synonym) psi-mi:tha11_human(display_long)|uniprotkb:THAP11(gene name)|psi-mi:THAP11(display_short)|uniprotkb:HRIHFB2206(orf name) psi-mi:"MI:0435"(protease assay) Dejosez et al. (2008) imex:IM-11926|pubmed:18585351 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-1791366|imex:IM-11926-1 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001271338.1|dip:DIP-44076N|refseq:NP_033940.1|refseq:XP_017168032.1|ensembl:ENSMUSG00000031628(gene)|ensembl:ENSMUST00000093517(transcript)|ensembl:ENSMUST00000211115(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0010033"(response to organic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P70677|reactome:R-MMU-111459|reactome:R-MMU-111465|reactome:R-MMU-111469|reactome:R-MMU-140342|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-264870|reactome:R-MMU-351906|reactome:R-MMU-418889|reactome:R-MMU-449836|reactome:R-MMU-5620971 refseq:NP_065190.2|dip:DIP-46732N|ensembl:ENSP00000304689|ensembl:ENSG00000168286(gene)|ensembl:ENST00000303596(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006612(Zinc finger, C2CH-type)|rcsb pdb:2LAU|rcsb pdb:5AJS go:"GO:0006508"(proteolysis) - crc64:25235D20CB54D8C2 resulting-ptm:"Cleavage of THAP11 (Q96EK4)"|figure legend:Supp. Fig. 1A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/07/10 2014/10/16 rogid:tSqWk4T+WiXomdMHEk4xthh9MZs10090 rogid:qzl6RN2xlTuDBruwyKLyDTNRCKE9606 intact-crc:AC2AB4F8786A9758|rigid:11ROnYMfCRyE61wpSRAu2iq/KrM false mutation:163-163 - - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining)