#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-7974451	uniprotkb:P70579	genbank_protein_gi:149029878|intact:MINT-6594144	intact:EBI-7974461|intact:MINT-235225	psi-mi:flna(display_short)|psi-mi:EBI-7974451(display_long)	psi-mi:grm8_rat(display_long)|uniprotkb:Grm8(gene name)|psi-mi:Grm8(display_short)|uniprotkb:Gprc1h(gene name synonym)|uniprotkb:Mglur8(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7974456|mint:MINT-6594140|imex:IM-14073-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:MINT-6594146(identity)	interpro:IPR017978|rgd:619858|refseq:NP_071538.1|interpro:IPR017979|interpro:IPR028082|mint:P70579|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|reactome:R-RNO-418594|reactome:R-RNO-420499|interpro:IPR000144(GPCR, family 3, metabotropic glutamate receptor 8)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR038550|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001642"(group III metabotropic glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|mint:MINT-6594142(identity)	-	comment:mint|no-uniprot-update:	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint	figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	-	rogid:R+st+0fAYUau53UFd/fwjhcfcVc10116	intact-crc:E87C416527BC0DEA	false	tag:?-?(MINT-6594151)	tag:?-?(MINT-6594147)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A4L9P5-2	uniprotkb:P97555	intact:EBI-7974503	intact:EBI-7974515|intact:MINT-6594129	psi-mi:a4l9p5-2(display_long)|uniprotkb:Hipk1(gene name)|psi-mi:Hipk1(display_short)	psi-mi:p97555_rat(display_long)|uniprotkb:mGluR8b(gene name)|psi-mi:mGluR8b(display_short)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7974510|mint:MINT-6594155|imex:IM-14073-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-22189297(isoform-parent)|mint:MINT-6594157(identity)	mint:P97555|mint:MINT-6594161(identity)	-	comment:mint	comment:"fragmentation type: fragment"|comment:mint	figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:aFcCgBUDs5COjNlO4USGsXX59Bs10116	rogid:N71myDEFlM+Omh2VrIksaBSLMgU10116	intact-crc:5E5CA1D6B05FBEDA|rigid:X+gAhAe8IYYuO9KbK6hFhZB2kkU	false	tag:?-?(MINT-6594158)	tag:?-?(MINT-6594162)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60889	uniprotkb:P97555	intact:EBI-7974536|intact:MINT-6594215|ensembl:ENSRNOP00000022631|ensembl:ENSRNOP00000074584	intact:EBI-7974515|intact:MINT-6594129	psi-mi:cbx7_rat(display_long)|uniprotkb:Cbx7(gene name)|psi-mi:Cbx7(display_short)	psi-mi:p97555_rat(display_long)|uniprotkb:mGluR8b(gene name)|psi-mi:mGluR8b(display_short)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7974559|mint:MINT-6594204|imex:IM-14073-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:735027|refseq:NP_954548.1|refseq:XP_006242087.1|ensembl:ENSRNOG00000016875(gene)|ensembl:ENSRNOT00000022631(transcript)|ensembl:ENSRNOT00000077731(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0003682"(chromatin binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0031519"(PcG protein complex)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035102"(PRC1 complex)|go:"GO:0042493"|go:"GO:0048733"(sebaceous gland development)|interpro:IPR000953(Chromo domain)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|interpro:IPR033773|interpro:IPR043000|mint:P60889|mint:MINT-6594206(identity)	mint:P97555|mint:MINT-6594210(identity)	-	function:Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity|comment:mint	comment:"fragmentation type: fragment"|comment:mint	figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:FGnNdS5FdJuSYgimzHvDHtDdXGo10116	rogid:N71myDEFlM+Omh2VrIksaBSLMgU10116	intact-crc:EED57542F8A0F13F|rigid:ohj87pCNjtxGryK6Rgtw+6H7mk0	false	tag:?-?(MINT-6594207)	tag:?-?(MINT-6594211)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97555	uniprotkb:A9UK05	intact:EBI-7974515|intact:MINT-6594129	intact:EBI-7974593|intact:MINT-6594236	psi-mi:p97555_rat(display_long)|uniprotkb:mGluR8b(gene name)|psi-mi:mGluR8b(display_short)	psi-mi:a9uk05_rat(display_long)|uniprotkb:Pias1(gene name)|psi-mi:Pias1(display_short)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7974614|mint:MINT-6594225|imex:IM-14073-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P97555|mint:MINT-6594231(identity)	interpro:IPR038654|rgd:1307843|interpro:IPR004181(Zinc finger, MIZ-type)|refseq:NP_001100299.2|interpro:IPR003034(DNA-binding SAP)|interpro:IPR023321|interpro:IPR036361|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|mint:A9UK05|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0065004"(protein-DNA complex assembly)|interpro:IPR027226|mint:MINT-6594227(identity)	-	comment:"fragmentation type: fragment"|comment:mint	comment:mint	figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:N71myDEFlM+Omh2VrIksaBSLMgU10116	rogid:eZCmfRPfv47Rszt/DpbQ77ZES1w10116	intact-crc:BDFF7C26F1D72794|rigid:s6DROaRjRCjbY5GiXtIz5lnaLds	false	tag:?-?(MINT-6594232)	tag:?-?(MINT-6594228)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O70260	uniprotkb:P97555	intact:EBI-7974636|intact:UNK-5365098|ensembl:ENSRNOP00000028814	intact:EBI-7974515|intact:MINT-6594129	psi-mi:pias3_rat(display_long)|uniprotkb:Pias3(gene name)|psi-mi:Pias3(display_short)|uniprotkb:Protein inhibitor of activated STAT protein 3(gene name synonym)|uniprotkb:Potassium channel-associated protein(gene name synonym)|uniprotkb:KChAP(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS3(gene name synonym)	psi-mi:p97555_rat(display_long)|uniprotkb:mGluR8b(gene name)|psi-mi:mGluR8b(display_short)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7974631|mint:MINT-6594245|imex:IM-14073-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:708413|refseq:NP_113972.2|dip:DIP-47656N|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0045202"(synapse)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O70260|reactome:R-RNO-3232118|reactome:R-RNO-3899300|reactome:R-RNO-4090294|reactome:R-RNO-4615885|reactome:R-RNO-4755510|reactome:R-RNO-5696395|ensembl:ENSRNOG00000021218(gene)|ensembl:ENSRNOT00000028814(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009725"(response to hormone)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|mint:MINT-6594247(identity)	mint:P97555|mint:MINT-6594251(identity)	-	comment:mint|function:"Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context"	comment:"fragmentation type: fragment"|comment:mint	figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:J7ttG9hUULFAIs8ybnii6v1lMRk10116	rogid:N71myDEFlM+Omh2VrIksaBSLMgU10116	intact-crc:8BBF14174F071C75|rigid:Nv5wf8I2BKJ0uK9B6TezQvq+jMw	false	tag:?-?(MINT-6594248)	tag:?-?(MINT-6594252)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97555	uniprotkb:Q62868	intact:EBI-7974515|intact:MINT-6594129	intact:EBI-1569209	psi-mi:p97555_rat(display_long)|uniprotkb:mGluR8b(gene name)|psi-mi:mGluR8b(display_short)	psi-mi:rock2_rat(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase II(gene name synonym)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 2(gene name synonym)|uniprotkb:p164 ROCK-2(gene name synonym)|uniprotkb:RhoA-binding kinase 2(gene name synonym)|uniprotkb:p150 ROK-alpha(gene name synonym)|uniprotkb:Rock2(gene name)|psi-mi:Rock2(display_short)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7974701|mint:MINT-6594320|imex:IM-14073-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P97555|mint:MINT-6594326(identity)	refseq:NP_037154.2|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|rgd:3590|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015008(Rho Binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011072(HR1 rho-binding repeat)|mint:Q62868|interpro:IPR037311|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016301"(kinase activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110061"(regulation of angiotensin-activated signaling pathway)|go:"GO:0150033"(negative regulation of protein localization to lysosome)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1905145"(cellular response to acetylcholine)|go:"GO:1905205"(positive regulation of connective tissue replacement)|go:"GO:1990776"(response to angiotensin)|rcsb pdb:2ROV|rcsb pdb:2ROW|reactome:R-RNO-3928662|reactome:R-RNO-416482|reactome:R-RNO-416572|reactome:R-RNO-4420097|reactome:R-RNO-5627117|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013407|reactome:R-RNO-9013422|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|mint:MINT-6594322(identity)	-	comment:"fragmentation type: fragment"|comment:mint	-	figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:N71myDEFlM+Omh2VrIksaBSLMgU10116	rogid:+6JfzBBwr8BQSjwdEvk0nnln18s10116	intact-crc:2869EB407588FF00|rigid:/GLIwEwmDykyU7GqozFqiekHhWA	false	tag:?-?(MINT-6594327)	tag:?-?(MINT-6594323)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97555	uniprotkb:Q96S59	intact:EBI-7974515|intact:MINT-6594129	intact:EBI-636085|uniprotkb:A0PJA2|uniprotkb:O94764|uniprotkb:Q6P3T7|uniprotkb:Q7LBR2|uniprotkb:Q7Z7F9|ensembl:ENSP00000011619|uniprotkb:B2R8E1	psi-mi:p97555_rat(display_long)|uniprotkb:mGluR8b(gene name)|psi-mi:mGluR8b(display_short)	psi-mi:ranb9_human(display_long)|uniprotkb:RanBP7(gene name synonym)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:BPM90(gene name synonym)|uniprotkb:BPM-L(gene name synonym)|uniprotkb:RANBP9(gene name)|psi-mi:RANBP9(display_short)|uniprotkb:RANBPM(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7974684|mint:MINT-6594257|imex:IM-14073-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P97555|mint:MINT-6594263(identity)	refseq:NP_005484.2|ensembl:ENSG00000010017(gene)|ensembl:ENST00000011619(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|interpro:IPR035782|interpro:IPR043136|mint:Q96S59|rcsb pdb:5JI7|rcsb pdb:5JI9|rcsb pdb:5JIU|rcsb pdb:7NSC|reactome:R-HSA-373760|reactome:R-HSA-5673001|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-HSA-8851805|refseq:XP_006715008.1|mint:MINT-6594259(identity)	-	comment:"fragmentation type: fragment"|comment:mint	-	figure legend:F1B F4A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:N71myDEFlM+Omh2VrIksaBSLMgU10116	rogid:7jybZidQAgnkobKmGJhZ9xsEeH09606	intact-crc:EF0826475F31273B|rigid:7LznWV7vDn4f1DhP5vQFhsv2lIU	false	tag:?-?(MINT-6594264)	tag:?-?(MINT-6594260)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97555	uniprotkb:D3ZNQ6	intact:EBI-7974515|intact:MINT-6594129	intact:EBI-7974778|intact:MINT-6594364|ensembl:ENSRNOP00000034271	psi-mi:p97555_rat(display_long)|uniprotkb:mGluR8b(gene name)|psi-mi:mGluR8b(display_short)	psi-mi:d3znq6_rat(display_long)|uniprotkb:Ube2m_predicted(gene name synonym)|uniprotkb:Ube2m(gene name)|psi-mi:Ube2m(display_short)|uniprotkb:rCG_27455(orf name)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7974797|mint:MINT-6594349|imex:IM-14073-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P97555|mint:MINT-6594355(identity)	refseq:NP_001101941.1|rgd:1307614|go:"GO:0045116"(protein neddylation)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:D3ZNQ6|reactome:R-RNO-2173789|reactome:R-RNO-5607761|reactome:R-RNO-5676590|reactome:R-RNO-8951664|reactome:R-RNO-983168|ensembl:ENSRNOG00000027514(gene)|ensembl:ENSRNOT00000031007(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|mint:MINT-6594351(identity)	-	comment:"fragmentation type: fragment"|comment:mint	comment:mint	figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:N71myDEFlM+Omh2VrIksaBSLMgU10116	rogid:YfRvkrP+nGQTtjeUsJNDbMm1Nqo10116	intact-crc:0AA07D8334EA53DF|rigid:mjXtebYH9ngwa6Bj3it5PjEK3wo	false	tag:?-?(MINT-6594356)	tag:?-?(MINT-6594352)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97555	uniprotkb:P63281	intact:EBI-7974515|intact:MINT-6594129	intact:EBI-7974723|intact:MINT-4568236|uniprotkb:P50550|uniprotkb:Q15698|uniprotkb:Q86VB3|ensembl:ENSRNOP00000024406	psi-mi:p97555_rat(display_long)|uniprotkb:mGluR8b(gene name)|psi-mi:mGluR8b(display_short)	psi-mi:ubc9_rat(display_long)|uniprotkb:Ube2i(gene name)|psi-mi:Ube2i(display_short)|uniprotkb:Ubce9(gene name synonym)|uniprotkb:SUMO-protein ligase(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 I(gene name synonym)|uniprotkb:Ubiquitin-protein ligase I(gene name synonym)|uniprotkb:Ubiquitin carrier protein I(gene name synonym)|uniprotkb:Ubiquitin carrier protein 9(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme UbcE2A(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase UBC9(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7974718|mint:MINT-6594335|imex:IM-14073-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P97555|mint:MINT-6594341(identity)	refseq:XP_006245981.1|refseq:XP_006245982.1|rgd:3926|refseq:NP_037182.1|refseq:XP_006245980.2|refseq:XP_008765771.2|refseq:XP_017452533.1|dip:DIP-47657N|ensembl:ENSRNOG00000017907(gene)|ensembl:ENSRNOT00000024406(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0033145"(positive regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051301"(cell division)|go:"GO:0061656"(SUMO conjugating enzyme activity)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:1903755"(positive regulation of SUMO transferase activity)|go:"GO:1990234"(transferase complex)|go:"GO:1990356"(sumoylated E2 ligase complex)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P63281|reactome:R-RNO-196791|reactome:R-RNO-3065678|reactome:R-RNO-3108214|reactome:R-RNO-3108232|reactome:R-RNO-3232118|reactome:R-RNO-3232142|reactome:R-RNO-3899300|reactome:R-RNO-4085377|reactome:R-RNO-4090294|reactome:R-RNO-4551638|reactome:R-RNO-4570464|reactome:R-RNO-4615885|reactome:R-RNO-4655427|reactome:R-RNO-4755510|reactome:R-RNO-5693565|reactome:R-RNO-5693607|reactome:R-RNO-5696395|reactome:R-RNO-8866904|reactome:R-RNO-9615933|mint:MINT-6594337(identity)	-	comment:"fragmentation type: fragment"|comment:mint	comment:mint|function:Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation	figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:N71myDEFlM+Omh2VrIksaBSLMgU10116	rogid:VV8ByrWqarJUmpoBqQ9EPZiGpFo10116	intact-crc:0615C82ECF61A121|rigid:3QbRHa7ZBG8gJjq3a1nrS8DrdxM	false	tag:?-?(MINT-6594342)	tag:?-?(MINT-6594338)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P31422	uniprotkb:Q96S59	intact:EBI-7974832|intact:MINT-1773162|ensembl:ENSRNOP00000007572	intact:EBI-636085|uniprotkb:A0PJA2|uniprotkb:O94764|uniprotkb:Q6P3T7|uniprotkb:Q7LBR2|uniprotkb:Q7Z7F9|ensembl:ENSP00000011619|uniprotkb:B2R8E1	psi-mi:grm3_rat(display_long)|uniprotkb:Grm3(gene name)|psi-mi:Grm3(display_short)|uniprotkb:Gprc1c(gene name synonym)|uniprotkb:Mglur3(gene name synonym)	psi-mi:ranb9_human(display_long)|uniprotkb:RanBP7(gene name synonym)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:BPM90(gene name synonym)|uniprotkb:BPM-L(gene name synonym)|uniprotkb:RANBP9(gene name)|psi-mi:RANBP9(display_short)|uniprotkb:RANBPM(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7974868|mint:MINT-6594443|imex:IM-14073-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001099182.1|rgd:2744|dip:DIP-41143N|ensembl:ENSRNOG00000005519(gene)|ensembl:ENSRNOT00000007572(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0010467"(gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001234(GPCR, family 3, metabotropic glutamate receptor 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:P31422|rcsb pdb:2E4U|rcsb pdb:2E4V|rcsb pdb:2E4W|rcsb pdb:2E4X|rcsb pdb:2E4Y|reactome:R-RNO-418594|reactome:R-RNO-420499|mint:MINT-6594445(identity)	refseq:NP_005484.2|ensembl:ENSG00000010017(gene)|ensembl:ENST00000011619(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|interpro:IPR035782|interpro:IPR043136|mint:Q96S59|rcsb pdb:5JI7|rcsb pdb:5JI9|rcsb pdb:5JIU|rcsb pdb:7NSC|reactome:R-HSA-373760|reactome:R-HSA-5673001|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-HSA-8851805|refseq:XP_006715008.1|mint:MINT-6594449(identity)	-	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint	-	figure legend:F4A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:seBDkbV7Eb+eVctXAZ9F1KWrgJI10116	rogid:7jybZidQAgnkobKmGJhZ9xsEeH09606	intact-crc:B3D2452E30ADE637|rigid:6aAbNLHb6py53KTZyokhuSPFCxo	false	tag:?-?(MINT-6594446)	tag:?-?(MINT-6594450)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31421	uniprotkb:Q96S59	intact:EBI-7090147|ensembl:ENSRNOP00000017607|intact:MINT-146442	intact:EBI-636085|uniprotkb:A0PJA2|uniprotkb:O94764|uniprotkb:Q6P3T7|uniprotkb:Q7LBR2|uniprotkb:Q7Z7F9|ensembl:ENSP00000011619|uniprotkb:B2R8E1	psi-mi:grm2_rat(display_long)|uniprotkb:Grm2(gene name)|psi-mi:Grm2(display_short)|uniprotkb:Gprc1b(gene name synonym)|uniprotkb:Mglur2(gene name synonym)	psi-mi:ranb9_human(display_long)|uniprotkb:RanBP7(gene name synonym)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:BPM90(gene name synonym)|uniprotkb:BPM-L(gene name synonym)|uniprotkb:RANBP9(gene name)|psi-mi:RANBP9(display_short)|uniprotkb:RANBPM(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7974814|mint:MINT-6594418|imex:IM-14073-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000013171(gene)|ensembl:ENSRNOT00000017607(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010467"(gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042220"(response to cocaine)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001458(GPCR, family 3, metabotropic glutamate receptor 2)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:P31421|reactome:R-RNO-418594|reactome:R-RNO-420499|refseq:XP_017450945.1|refseq:XP_017450946.1|refseq:NP_001099181.1|rgd:2743|dip:DIP-41937N|mint:MINT-6594420(identity)	refseq:NP_005484.2|ensembl:ENSG00000010017(gene)|ensembl:ENST00000011619(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|interpro:IPR035782|interpro:IPR043136|mint:Q96S59|rcsb pdb:5JI7|rcsb pdb:5JI9|rcsb pdb:5JIU|rcsb pdb:7NSC|reactome:R-HSA-373760|reactome:R-HSA-5673001|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-HSA-8851805|refseq:XP_006715008.1|mint:MINT-6594424(identity)	-	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization|comment:mint	-	figure legend:F4A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:LVjjD/Uvv4io40UWVuFTCMetoxw10116	rogid:7jybZidQAgnkobKmGJhZ9xsEeH09606	intact-crc:63BC5E880AD078EB|rigid:mXrlfCyFAMwXIsUSlSilE5kDdcc	false	tag:?-?(MINT-6594421)	tag:?-?(MINT-6594425)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35400	uniprotkb:Q96S59	intact:EBI-6936416|intact:MINT-146474	intact:EBI-636085|uniprotkb:A0PJA2|uniprotkb:O94764|uniprotkb:Q6P3T7|uniprotkb:Q7LBR2|uniprotkb:Q7Z7F9|ensembl:ENSP00000011619|uniprotkb:B2R8E1	psi-mi:grm7_rat(display_long)|uniprotkb:Grm7(gene name)|psi-mi:Grm7(display_short)|uniprotkb:Gprc1g(gene name synonym)|uniprotkb:Mglur7(gene name synonym)	psi-mi:ranb9_human(display_long)|uniprotkb:RanBP7(gene name synonym)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:BPM90(gene name synonym)|uniprotkb:BPM-L(gene name synonym)|uniprotkb:RANBP9(gene name)|psi-mi:RANBP9(display_short)|uniprotkb:RANBPM(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7974956|mint:MINT-6594519|imex:IM-14073-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007614"(short-term memory)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010855"(adenylate cyclase inhibitor activity)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050877"(nervous system process)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061564"(axon development)|go:"GO:0070085"(glycosylation)|go:"GO:0070905"(serine binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR001883(GPCR, family 3, metabotropic glutamate receptor 7)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|rcsb pdb:2E4Z|reactome:R-RNO-418594|reactome:R-RNO-420499|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001642"(group III metabotropic glutamate receptor activity)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|refseq:NP_112302.1|rgd:619857|mint:P35400|dip:DIP-41145N|mint:MINT-6594521(identity)	refseq:NP_005484.2|ensembl:ENSG00000010017(gene)|ensembl:ENST00000011619(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|interpro:IPR035782|interpro:IPR043136|mint:Q96S59|rcsb pdb:5JI7|rcsb pdb:5JI9|rcsb pdb:5JIU|rcsb pdb:7NSC|reactome:R-HSA-373760|reactome:R-HSA-5673001|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-HSA-8851805|refseq:XP_006715008.1|mint:MINT-6594525(identity)	-	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint	-	figure legend:F4A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:4p27GEshqsLLsQueJLDdVAXV6BY10116	rogid:7jybZidQAgnkobKmGJhZ9xsEeH09606	intact-crc:A8C932830E4395F9|rigid:9ofeP5iu0OuwekpWeh5q4Zd0JwM	false	tag:?-?(MINT-6594522)	tag:?-?(MINT-6594526)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31423	uniprotkb:Q96S59	intact:EBI-7974891|intact:MINT-235145	intact:EBI-636085|uniprotkb:A0PJA2|uniprotkb:O94764|uniprotkb:Q6P3T7|uniprotkb:Q7LBR2|uniprotkb:Q7Z7F9|ensembl:ENSP00000011619|uniprotkb:B2R8E1	psi-mi:grm4_rat(display_long)|uniprotkb:Grm4(gene name)|psi-mi:Grm4(display_short)|uniprotkb:Gprc1d(gene name synonym)|uniprotkb:Mglur4(gene name synonym)	psi-mi:ranb9_human(display_long)|uniprotkb:RanBP7(gene name synonym)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:BPM90(gene name synonym)|uniprotkb:BPM-L(gene name synonym)|uniprotkb:RANBP9(gene name)|psi-mi:RANBP9(display_short)|uniprotkb:RANBPM(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7974886|mint:MINT-6594507|imex:IM-14073-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2745|refseq:NP_073157.1|dip:DIP-41144N|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|mint:P31423|interpro:IPR000337(GPCR, family 3)|interpro:IPR001786(GPCR, family 3, metabotropic glutamate receptor 4)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|reactome:R-RNO-418594|reactome:R-RNO-420499|mint:MINT-6594509(identity)	refseq:NP_005484.2|ensembl:ENSG00000010017(gene)|ensembl:ENST00000011619(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|interpro:IPR035782|interpro:IPR043136|mint:Q96S59|rcsb pdb:5JI7|rcsb pdb:5JI9|rcsb pdb:5JIU|rcsb pdb:7NSC|reactome:R-HSA-373760|reactome:R-HSA-5673001|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-HSA-8851805|refseq:XP_006715008.1|mint:MINT-6594513(identity)	-	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint	-	figure legend:F4A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:Q+SUUFPoCxp8dLjZM9SC2wvqS4M10116	rogid:7jybZidQAgnkobKmGJhZ9xsEeH09606	intact-crc:A6F78F93C9052726|rigid:2gvBpX3bFQyofGr3q0jdNG65dOc	false	tag:?-?(MINT-6594510)	tag:?-?(MINT-6594514)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P70579	uniprotkb:P60889	intact:EBI-7974461|intact:MINT-235225	intact:EBI-7974536|intact:MINT-6594215|ensembl:ENSRNOP00000022631|ensembl:ENSRNOP00000074584	psi-mi:grm8_rat(display_long)|uniprotkb:Grm8(gene name)|psi-mi:Grm8(display_short)|uniprotkb:Gprc1h(gene name synonym)|uniprotkb:Mglur8(gene name synonym)	psi-mi:cbx7_rat(display_long)|uniprotkb:Cbx7(gene name)|psi-mi:Cbx7(display_short)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7974973|mint:MINT-6597021|imex:IM-14073-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017978|rgd:619858|refseq:NP_071538.1|interpro:IPR017979|interpro:IPR028082|mint:P70579|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|reactome:R-RNO-418594|reactome:R-RNO-420499|interpro:IPR000144(GPCR, family 3, metabotropic glutamate receptor 8)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR038550|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001642"(group III metabotropic glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|mint:MINT-6597027(identity)	rgd:735027|refseq:NP_954548.1|refseq:XP_006242087.1|ensembl:ENSRNOG00000016875(gene)|ensembl:ENSRNOT00000022631(transcript)|ensembl:ENSRNOT00000077731(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0003682"(chromatin binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0031519"(PcG protein complex)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035102"(PRC1 complex)|go:"GO:0042493"|go:"GO:0048733"(sebaceous gland development)|interpro:IPR000953(Chromo domain)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|interpro:IPR033773|interpro:IPR043000|mint:P60889|mint:MINT-6597023(identity)	-	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint	function:Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity|comment:mint	figure legend:F1B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:R+st+0fAYUau53UFd/fwjhcfcVc10116	rogid:FGnNdS5FdJuSYgimzHvDHtDdXGo10116	intact-crc:3359A3651D2D45D1|rigid:tFMuyw0IZCwJALZioA31IQmTCIQ	false	tag:?-?(MINT-6597028)	tag:?-?(MINT-6597024)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70579	uniprotkb:Q96S59	intact:EBI-7974461|intact:MINT-235225	intact:EBI-636085|uniprotkb:A0PJA2|uniprotkb:O94764|uniprotkb:Q6P3T7|uniprotkb:Q7LBR2|uniprotkb:Q7Z7F9|ensembl:ENSP00000011619|uniprotkb:B2R8E1	psi-mi:grm8_rat(display_long)|uniprotkb:Grm8(gene name)|psi-mi:Grm8(display_short)|uniprotkb:Gprc1h(gene name synonym)|uniprotkb:Mglur8(gene name synonym)	psi-mi:ranb9_human(display_long)|uniprotkb:RanBP7(gene name synonym)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:BPM90(gene name synonym)|uniprotkb:BPM-L(gene name synonym)|uniprotkb:RANBP9(gene name)|psi-mi:RANBP9(display_short)|uniprotkb:RANBPM(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7974991|mint:MINT-6597032|imex:IM-14073-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017978|rgd:619858|refseq:NP_071538.1|interpro:IPR017979|interpro:IPR028082|mint:P70579|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|reactome:R-RNO-418594|reactome:R-RNO-420499|interpro:IPR000144(GPCR, family 3, metabotropic glutamate receptor 8)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR038550|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001642"(group III metabotropic glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|mint:MINT-6597038(identity)	refseq:NP_005484.2|ensembl:ENSG00000010017(gene)|ensembl:ENST00000011619(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|interpro:IPR035782|interpro:IPR043136|mint:Q96S59|rcsb pdb:5JI7|rcsb pdb:5JI9|rcsb pdb:5JIU|rcsb pdb:7NSC|reactome:R-HSA-373760|reactome:R-HSA-5673001|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-HSA-8851805|refseq:XP_006715008.1|mint:MINT-6597034(identity)	-	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint	-	figure legend:F1B F4A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:R+st+0fAYUau53UFd/fwjhcfcVc10116	rogid:7jybZidQAgnkobKmGJhZ9xsEeH09606	intact-crc:7E90E0E99F3EBCC9|rigid:WGtKBYFit4+QD+uZ1gUDRErLDTo	false	tag:?-?(MINT-6597039)	tag:?-?(MINT-6597035)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70579	uniprotkb:Q62868	intact:EBI-7974461|intact:MINT-235225	intact:EBI-1569209	psi-mi:grm8_rat(display_long)|uniprotkb:Grm8(gene name)|psi-mi:Grm8(display_short)|uniprotkb:Gprc1h(gene name synonym)|uniprotkb:Mglur8(gene name synonym)	psi-mi:rock2_rat(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase II(gene name synonym)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 2(gene name synonym)|uniprotkb:p164 ROCK-2(gene name synonym)|uniprotkb:RhoA-binding kinase 2(gene name synonym)|uniprotkb:p150 ROK-alpha(gene name synonym)|uniprotkb:Rock2(gene name)|psi-mi:Rock2(display_short)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7975034|mint:MINT-6597043|imex:IM-14073-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017978|rgd:619858|refseq:NP_071538.1|interpro:IPR017979|interpro:IPR028082|mint:P70579|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|reactome:R-RNO-418594|reactome:R-RNO-420499|interpro:IPR000144(GPCR, family 3, metabotropic glutamate receptor 8)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR038550|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001642"(group III metabotropic glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|mint:MINT-6597049(identity)	refseq:NP_037154.2|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|rgd:3590|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015008(Rho Binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011072(HR1 rho-binding repeat)|mint:Q62868|interpro:IPR037311|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016301"(kinase activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110061"(regulation of angiotensin-activated signaling pathway)|go:"GO:0150033"(negative regulation of protein localization to lysosome)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1905145"(cellular response to acetylcholine)|go:"GO:1905205"(positive regulation of connective tissue replacement)|go:"GO:1990776"(response to angiotensin)|rcsb pdb:2ROV|rcsb pdb:2ROW|reactome:R-RNO-3928662|reactome:R-RNO-416482|reactome:R-RNO-416572|reactome:R-RNO-4420097|reactome:R-RNO-5627117|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013407|reactome:R-RNO-9013422|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|mint:MINT-6597045(identity)	-	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint	-	figure legend:F1B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:R+st+0fAYUau53UFd/fwjhcfcVc10116	rogid:+6JfzBBwr8BQSjwdEvk0nnln18s10116	intact-crc:70D92052D8605EED|rigid:sYI7AcSML397nyhApvZhWfjdcuE	false	tag:?-?(MINT-6597050)	tag:?-?(MINT-6597046)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:D3ZNQ6	uniprotkb:P70579	intact:EBI-7974778|intact:MINT-6594364|ensembl:ENSRNOP00000034271	intact:EBI-7974461|intact:MINT-235225	psi-mi:d3znq6_rat(display_long)|uniprotkb:Ube2m_predicted(gene name synonym)|uniprotkb:Ube2m(gene name)|psi-mi:Ube2m(display_short)|uniprotkb:rCG_27455(orf name)	psi-mi:grm8_rat(display_long)|uniprotkb:Grm8(gene name)|psi-mi:Grm8(display_short)|uniprotkb:Gprc1h(gene name synonym)|uniprotkb:Mglur8(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7975052|mint:MINT-6597054|imex:IM-14073-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001101941.1|rgd:1307614|go:"GO:0045116"(protein neddylation)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:D3ZNQ6|reactome:R-RNO-2173789|reactome:R-RNO-5607761|reactome:R-RNO-5676590|reactome:R-RNO-8951664|reactome:R-RNO-983168|ensembl:ENSRNOG00000027514(gene)|ensembl:ENSRNOT00000031007(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|mint:MINT-6597056(identity)	interpro:IPR017978|rgd:619858|refseq:NP_071538.1|interpro:IPR017979|interpro:IPR028082|mint:P70579|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|reactome:R-RNO-418594|reactome:R-RNO-420499|interpro:IPR000144(GPCR, family 3, metabotropic glutamate receptor 8)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR038550|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001642"(group III metabotropic glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|mint:MINT-6597060(identity)	-	comment:mint	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint	figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:YfRvkrP+nGQTtjeUsJNDbMm1Nqo10116	rogid:R+st+0fAYUau53UFd/fwjhcfcVc10116	intact-crc:358F4F55152C67BC|rigid:9v8901Hnt+ZhRe2MkLIffFMKwN0	false	tag:?-?(MINT-6597057)	tag:?-?(MINT-6597061)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63337	uniprotkb:Q96S59	intact:EBI-6935714|intact:MINT-1792850	intact:EBI-636085|uniprotkb:A0PJA2|uniprotkb:O94764|uniprotkb:Q6P3T7|uniprotkb:Q7LBR2|uniprotkb:Q7Z7F9|ensembl:ENSP00000011619|uniprotkb:B2R8E1	psi-mi:q63337_rat(display_long)|uniprotkb:mGluR7(gene name)|psi-mi:mGluR7(display_short)	psi-mi:ranb9_human(display_long)|uniprotkb:RanBP7(gene name synonym)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:BPM90(gene name synonym)|uniprotkb:BPM-L(gene name synonym)|uniprotkb:RANBP9(gene name)|psi-mi:RANBP9(display_short)|uniprotkb:RANBPM(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7975069|mint:MINT-6597070|imex:IM-14073-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q63337|mint:MINT-6597076(identity)	refseq:NP_005484.2|ensembl:ENSG00000010017(gene)|ensembl:ENST00000011619(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|interpro:IPR035782|interpro:IPR043136|mint:Q96S59|rcsb pdb:5JI7|rcsb pdb:5JI9|rcsb pdb:5JIU|rcsb pdb:7NSC|reactome:R-HSA-373760|reactome:R-HSA-5673001|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-HSA-8851805|refseq:XP_006715008.1|mint:MINT-6597072(identity)	-	comment:"fragmentation type: fragment"|comment:mint	-	figure legend:F4A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/06/05	2014/10/16	rogid:Csjqgjr2yXkNiMRANeN+3BfJ2Ic10116	rogid:7jybZidQAgnkobKmGJhZ9xsEeH09606	intact-crc:3B31B8F240543B05|rigid:XeRMflNElE49qkZPo4LmlMhJQoA	false	tag:?-?(MINT-6597077)	tag:?-?(MINT-6597073)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47743	uniprotkb:P69566	intact:EBI-7975122|intact:UNK-5378405|uniprotkb:Q6B964|ensembl:ENSMUSP00000087998	intact:EBI-772305|uniprotkb:P84500|uniprotkb:Q3V136	psi-mi:grm8_mouse(display_long)|uniprotkb:Grm8(gene name)|psi-mi:Grm8(display_short)|uniprotkb:Gprc1h(gene name synonym)|uniprotkb:Mglur8(gene name synonym)	psi-mi:ranb9_mouse(display_long)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:B-cell antigen receptor Ig beta-associated protein 1(gene name synonym)|uniprotkb:Ranbp9(gene name)|psi-mi:Ranbp9(display_short)|uniprotkb:Ranbpm(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7975116|mint:MINT-6594383|imex:IM-14073-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001298001.1|refseq:XP_017176886.1|ensembl:ENSMUSG00000024211(gene)|ensembl:ENSMUST00000090512(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001642"(group III metabotropic glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000144(GPCR, family 3, metabotropic glutamate receptor 8)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:P47743|reactome:R-MMU-418594|reactome:R-MMU-420499|mint:MINT-6594385(identity)	refseq:NP_064314.2|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|mint:P69566|interpro:IPR035782|interpro:IPR043136|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-MMU-373760|reactome:R-MMU-5673001|reactome:R-MMU-8851805|mint:MINT-6594386(identity)	-	comment:mint|function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity	-	figure legend:F2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-retina)|taxid:10090(Mus musculus retina)	-	2008/06/05	2014/10/16	rogid:J7fv1/V+nChr7ErC5Tegmm+4hT810090	rogid:nKjsQ+KN8Z4mWEyQcRejUCLSDJY10090	intact-crc:CDD1ACFE70C74C20|rigid:aC1Ylu+1LYttcGN+WVDg3cp7NRU	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q14BI2	uniprotkb:P69566	intact:EBI-5281533|ensembl:ENSMUSP00000023959	intact:EBI-772305|uniprotkb:P84500|uniprotkb:Q3V136	psi-mi:grm2_mouse(display_long)|uniprotkb:Grm2(gene name)|psi-mi:Grm2(display_short)|uniprotkb:Gprc1b(gene name synonym)|uniprotkb:Mglur2(gene name synonym)	psi-mi:ranb9_mouse(display_long)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:B-cell antigen receptor Ig beta-associated protein 1(gene name synonym)|uniprotkb:Ranbp9(gene name)|psi-mi:Ranbp9(display_short)|uniprotkb:Ranbpm(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7975171|mint:MINT-6594392|imex:IM-14073-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153825.1|ensembl:ENSMUSG00000023192(gene)|ensembl:ENSMUST00000023959(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010467"(gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042220"(response to cocaine)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001458(GPCR, family 3, metabotropic glutamate receptor 2)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:Q14BI2|reactome:R-MMU-418594|reactome:R-MMU-420499|mint:MINT-6594396(identity)	refseq:NP_064314.2|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|mint:P69566|interpro:IPR035782|interpro:IPR043136|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-MMU-373760|reactome:R-MMU-5673001|reactome:R-MMU-8851805|mint:MINT-6594394(identity)	-	-	-	figure legend:F3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-retina)|taxid:10090(Mus musculus retina)	-	2008/06/05	2014/10/16	rogid:51Vq4ZsTylhat6thFK/8MBMIKUI10090	rogid:nKjsQ+KN8Z4mWEyQcRejUCLSDJY10090	intact-crc:7598FBF8CB8A9E59|rigid:WnIntGD1xKE6Htc0KNguTxO0eKo	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P31421	uniprotkb:Q96S59	intact:EBI-7090147|ensembl:ENSRNOP00000017607|intact:MINT-146442	intact:EBI-636085|uniprotkb:A0PJA2|uniprotkb:O94764|uniprotkb:Q6P3T7|uniprotkb:Q7LBR2|uniprotkb:Q7Z7F9|ensembl:ENSP00000011619|uniprotkb:B2R8E1	psi-mi:grm2_rat(display_long)|uniprotkb:Grm2(gene name)|psi-mi:Grm2(display_short)|uniprotkb:Gprc1b(gene name synonym)|uniprotkb:Mglur2(gene name synonym)	psi-mi:ranb9_human(display_long)|uniprotkb:RanBP7(gene name synonym)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:BPM90(gene name synonym)|uniprotkb:BPM-L(gene name synonym)|uniprotkb:RANBP9(gene name)|psi-mi:RANBP9(display_short)|uniprotkb:RANBPM(gene name synonym)	psi-mi:"MI:0096"(pull down)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7975264|mint:MINT-6594862|imex:IM-14073-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000013171(gene)|ensembl:ENSRNOT00000017607(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010467"(gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042220"(response to cocaine)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001458(GPCR, family 3, metabotropic glutamate receptor 2)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:P31421|reactome:R-RNO-418594|reactome:R-RNO-420499|refseq:XP_017450945.1|refseq:XP_017450946.1|refseq:NP_001099181.1|rgd:2743|dip:DIP-41937N|mint:MINT-6594866(identity)	refseq:NP_005484.2|ensembl:ENSG00000010017(gene)|ensembl:ENST00000011619(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|interpro:IPR035782|interpro:IPR043136|mint:Q96S59|rcsb pdb:5JI7|rcsb pdb:5JI9|rcsb pdb:5JIU|rcsb pdb:7NSC|reactome:R-HSA-373760|reactome:R-HSA-5673001|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-HSA-8851805|refseq:XP_006715008.1|mint:MINT-6594864(identity)	-	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization|comment:mint	-	figure legend:F4B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/05	2014/10/16	rogid:LVjjD/Uvv4io40UWVuFTCMetoxw10116	rogid:7jybZidQAgnkobKmGJhZ9xsEeH09606	intact-crc:8D901D8F7ABF0A8B|rigid:mXrlfCyFAMwXIsUSlSilE5kDdcc	false	glutathione s tranferase tag:?-?(MINT-6594867)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P31421	uniprotkb:Q96S59	intact:EBI-7090147|ensembl:ENSRNOP00000017607|intact:MINT-146442	intact:EBI-636085|uniprotkb:A0PJA2|uniprotkb:O94764|uniprotkb:Q6P3T7|uniprotkb:Q7LBR2|uniprotkb:Q7Z7F9|ensembl:ENSP00000011619|uniprotkb:B2R8E1	psi-mi:grm2_rat(display_long)|uniprotkb:Grm2(gene name)|psi-mi:Grm2(display_short)|uniprotkb:Gprc1b(gene name synonym)|uniprotkb:Mglur2(gene name synonym)	psi-mi:ranb9_human(display_long)|uniprotkb:RanBP7(gene name synonym)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:BPM90(gene name synonym)|uniprotkb:BPM-L(gene name synonym)|uniprotkb:RANBP9(gene name)|psi-mi:RANBP9(display_short)|uniprotkb:RANBPM(gene name synonym)	psi-mi:"MI:0096"(pull down)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7975203|mint:MINT-6594695|imex:IM-14073-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000013171(gene)|ensembl:ENSRNOT00000017607(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010467"(gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042220"(response to cocaine)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001458(GPCR, family 3, metabotropic glutamate receptor 2)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:P31421|reactome:R-RNO-418594|reactome:R-RNO-420499|refseq:XP_017450945.1|refseq:XP_017450946.1|refseq:NP_001099181.1|rgd:2743|dip:DIP-41937N|mint:MINT-6594697(identity)	refseq:NP_005484.2|ensembl:ENSG00000010017(gene)|ensembl:ENST00000011619(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|interpro:IPR035782|interpro:IPR043136|mint:Q96S59|rcsb pdb:5JI7|rcsb pdb:5JI9|rcsb pdb:5JIU|rcsb pdb:7NSC|reactome:R-HSA-373760|reactome:R-HSA-5673001|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-HSA-8851805|refseq:XP_006715008.1|mint:MINT-6594698(identity)	-	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization|comment:mint	-	figure legend:F4B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/05	2014/10/16	rogid:LVjjD/Uvv4io40UWVuFTCMetoxw10116	rogid:7jybZidQAgnkobKmGJhZ9xsEeH09606	intact-crc:128536D5AF4C947C|rigid:mXrlfCyFAMwXIsUSlSilE5kDdcc	false	glutathione s tranferase tag:?-?(MINT-6594849)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P31421	uniprotkb:Q96S59	intact:EBI-7090147|ensembl:ENSRNOP00000017607|intact:MINT-146442	intact:EBI-636085|uniprotkb:A0PJA2|uniprotkb:O94764|uniprotkb:Q6P3T7|uniprotkb:Q7LBR2|uniprotkb:Q7Z7F9|ensembl:ENSP00000011619|uniprotkb:B2R8E1	psi-mi:grm2_rat(display_long)|uniprotkb:Grm2(gene name)|psi-mi:Grm2(display_short)|uniprotkb:Gprc1b(gene name synonym)|uniprotkb:Mglur2(gene name synonym)	psi-mi:ranb9_human(display_long)|uniprotkb:RanBP7(gene name synonym)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:BPM90(gene name synonym)|uniprotkb:BPM-L(gene name synonym)|uniprotkb:RANBP9(gene name)|psi-mi:RANBP9(display_short)|uniprotkb:RANBPM(gene name synonym)	psi-mi:"MI:0096"(pull down)	Seebahn et al. (2008)	pubmed:18555800|imex:IM-14073|mint:MINT-6594124	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7975296|mint:MINT-6594947|imex:IM-14073-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000013171(gene)|ensembl:ENSRNOT00000017607(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010467"(gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042220"(response to cocaine)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001458(GPCR, family 3, metabotropic glutamate receptor 2)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:P31421|reactome:R-RNO-418594|reactome:R-RNO-420499|refseq:XP_017450945.1|refseq:XP_017450946.1|refseq:NP_001099181.1|rgd:2743|dip:DIP-41937N|mint:MINT-6594949(identity)	refseq:NP_005484.2|ensembl:ENSG00000010017(gene)|ensembl:ENST00000011619(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|interpro:IPR035782|interpro:IPR043136|mint:Q96S59|rcsb pdb:5JI7|rcsb pdb:5JI9|rcsb pdb:5JIU|rcsb pdb:7NSC|reactome:R-HSA-373760|reactome:R-HSA-5673001|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-HSA-8851805|refseq:XP_006715008.1|mint:MINT-6594953(identity)	-	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization|comment:mint	-	figure legend:F4C|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/05	2014/10/16	rogid:LVjjD/Uvv4io40UWVuFTCMetoxw10116	rogid:7jybZidQAgnkobKmGJhZ9xsEeH09606	intact-crc:270C042A08006F19|rigid:mXrlfCyFAMwXIsUSlSilE5kDdcc	false	glutathione s tranferase tag:?-?(MINT-6594950)	binding-associated region:403-614(MINT-6594979)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)