#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O27552	uniprotkb:O27132	intact:EBI-7963108|intact:MINT-6551018|ensemblbacteria:AAB85983	intact:EBI-7963138|intact:MINT-6551005|ensemblbacteria:AAB85549	psi-mi:syl_metth(display_long)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym)|uniprotkb:MTH_1508(locus name)|uniprotkb:leuS(gene name)|psi-mi:leuS(display_short)	psi-mi:ef1a_metth(display_long)|uniprotkb:tuf(gene name)|psi-mi:tuf(display_short)|uniprotkb:MTH_1058(locus name)|uniprotkb:Elongation factor Tu(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hausmann et al. (2008)	pubmed:18538672|imex:IM-14070|mint:MINT-6550998	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7963131|mint:MINT-6551032|imex:IM-14070-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR020791|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|mint:O27552|ensemblbacteria:AAB85983(transcript)|ensemblbacteria:MTH_1508(gene)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|mint:MINT-6551035(identity)	refseq:WP_010876684.1|interpro:IPR031157|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR005225(Small GTP-binding protein)|mint:O27132|ensemblbacteria:AAB85549(transcript)|ensemblbacteria:MTH_1058(gene)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|mint:MINT-6551034(identity)	-	comment:mint	comment:mint|function:This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	figure legend:f2|kinetics:kd 280 nanomolar|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/28	2014/10/16	rogid:rtE3wPOaBxN6j5QEC5j976nvPwo187420	rogid:vMP6Kz+xOg6in2KRBeBmmcXR6sk187420	intact-crc:249BE7884B756EF0|rigid:MDKnGE4Rl3Kod4rW3aNWN2r1a6A	false	his tag:?-?(MINT-6551036)|binding-associated region:196-422(MINT-6551081)	his tag:?-?(MINT-6551040)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O27585	uniprotkb:O27552	intact:EBI-7963255|intact:MINT-6664477|ensemblbacteria:AAB86016	intact:EBI-7963108|intact:MINT-6551018|ensemblbacteria:AAB85983	psi-mi:syk_metth(display_long)|uniprotkb:Lysyl-tRNA synthetase(gene name synonym)|uniprotkb:MTH_1542(locus name)|uniprotkb:lysS(gene name)|psi-mi:lysS(display_short)	psi-mi:syl_metth(display_long)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym)|uniprotkb:MTH_1508(locus name)|uniprotkb:leuS(gene name)|psi-mi:leuS(display_short)	psi-mi:"MI:0051"(fluorescence technology)	Hausmann et al. (2008)	pubmed:18538672|imex:IM-14070|mint:MINT-6550998	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7963274|mint:MINT-6664464|imex:IM-14070-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002904(Lysyl-tRNA synthetase, class Ic, archaeal)|interpro:IPR020751|interpro:IPR008925(Aminoacyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|mint:O27585|ensemblbacteria:AAB86016(transcript)|ensemblbacteria:MTH_1542(gene)|go:"GO:0000049"(tRNA binding)|go:"GO:0004824"(lysine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006430"(lysyl-tRNA aminoacylation)|mint:MINT-6664466(identity)	interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR020791|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|mint:O27552|ensemblbacteria:AAB85983(transcript)|ensemblbacteria:MTH_1508(gene)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|mint:MINT-6664470(identity)	-	comment:mint	comment:mint	figure legend:t2|kinetics:kd 40 nanomolar|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/28	2014/10/16	rogid:4cySOY1XGWy3JNjPqzzrC9DxkGA187420	rogid:rtE3wPOaBxN6j5QEC5j976nvPwo187420	intact-crc:224964C6EAAE2166|rigid:sXjC4jK425DdDAD0iZRCEvIJAlc	false	his tag:?-?(MINT-6664467)	mutation increasing interaction:196-492(MINT-6664493)|his tag:?-?(MINT-6664473)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O27552	uniprotkb:O27132	intact:EBI-7963108|intact:MINT-6551018|ensemblbacteria:AAB85983	intact:EBI-7963138|intact:MINT-6551005|ensemblbacteria:AAB85549	psi-mi:syl_metth(display_long)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym)|uniprotkb:MTH_1508(locus name)|uniprotkb:leuS(gene name)|psi-mi:leuS(display_short)	psi-mi:ef1a_metth(display_long)|uniprotkb:tuf(gene name)|psi-mi:tuf(display_short)|uniprotkb:MTH_1058(locus name)|uniprotkb:Elongation factor Tu(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Hausmann et al. (2008)	pubmed:18538672|imex:IM-14070|mint:MINT-6550998	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7963232|mint:MINT-6664443|imex:IM-14070-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR020791|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|mint:O27552|ensemblbacteria:AAB85983(transcript)|ensemblbacteria:MTH_1508(gene)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|mint:MINT-6664445(identity)	refseq:WP_010876684.1|interpro:IPR031157|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR005225(Small GTP-binding protein)|mint:O27132|ensemblbacteria:AAB85549(transcript)|ensemblbacteria:MTH_1058(gene)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|mint:MINT-6664451(identity)	-	comment:mint	comment:mint|function:This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	figure legend:t2|kinetics:kd 90 nanomolar|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/28	2014/10/16	rogid:rtE3wPOaBxN6j5QEC5j976nvPwo187420	rogid:vMP6Kz+xOg6in2KRBeBmmcXR6sk187420	intact-crc:5E048E163CCA07ED|rigid:MDKnGE4Rl3Kod4rW3aNWN2r1a6A	false	his tag:?-?(MINT-6664446)|mutation disrupting interaction:196-422(MINT-6664514)	his tag:?-?(MINT-6664452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O26708	uniprotkb:O27552	intact:EBI-7963357|intact:MINT-6664518|ensemblbacteria:AAB85117	intact:EBI-7963108|intact:MINT-6551018|ensemblbacteria:AAB85983	psi-mi:syp_metth(display_long)|uniprotkb:Prolyl-tRNA synthetase(gene name synonym)|uniprotkb:MTH_611(locus name)|uniprotkb:proS(gene name)|psi-mi:proS(display_short)	psi-mi:syl_metth(display_long)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym)|uniprotkb:MTH_1508(locus name)|uniprotkb:leuS(gene name)|psi-mi:leuS(display_short)	psi-mi:"MI:0051"(fluorescence technology)	Hausmann et al. (2008)	pubmed:18538672|imex:IM-14070|mint:MINT-6550998	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7963424|mint:MINT-6664558|imex:IM-14070-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017449(Prolyl-tRNA synthetase, class II)|interpro:IPR002316(Prolyl-tRNA synthetase, class IIa)|interpro:IPR016061(Prolyl-tRNA synthetase, class II, C-terminal)|interpro:IPR004499(Prolyl-tRNA synthetase, class IIa, prokaryotic-type)|interpro:IPR004154(Anticodon-binding)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR033721|mint:O26708|ensemblbacteria:AAB85117(transcript)|ensemblbacteria:MTH_611(gene)|go:"GO:0004827"(proline-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006433"(prolyl-tRNA aminoacylation)|go:"GO:0046872"(metal ion binding)|rcsb pdb:1NJ1|rcsb pdb:1NJ2|rcsb pdb:1NJ5|rcsb pdb:1NJ6|interpro:IPR036621|mint:MINT-6664560(identity)	interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR020791|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|mint:O27552|ensemblbacteria:AAB85983(transcript)|ensemblbacteria:MTH_1508(gene)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|mint:MINT-6664564(identity)	-	function:"Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). Can inadvertently accommodate and process cysteine"|comment:mint	comment:mint	figure legend:t2|kinetics:kd 110 nanomolar|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/28	2014/10/16	rogid:1WYxQSxmAFC9qL3tg5p/POkquts187420	rogid:rtE3wPOaBxN6j5QEC5j976nvPwo187420	intact-crc:D8BEB5BE552FBB63|rigid:42C8ttaM0VrSm1iZlRcYA9tAjHQ	false	his tag:?-?(MINT-6664561)	mutation decreasing interaction:1-8(MINT-6664571)|his tag:?-?(MINT-6664565)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O27552	uniprotkb:O26708	intact:EBI-7963108|intact:MINT-6551018|ensemblbacteria:AAB85983	intact:EBI-7963357|intact:MINT-6664518|ensemblbacteria:AAB85117	psi-mi:syl_metth(display_long)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym)|uniprotkb:MTH_1508(locus name)|uniprotkb:leuS(gene name)|psi-mi:leuS(display_short)	psi-mi:syp_metth(display_long)|uniprotkb:Prolyl-tRNA synthetase(gene name synonym)|uniprotkb:MTH_611(locus name)|uniprotkb:proS(gene name)|psi-mi:proS(display_short)	psi-mi:"MI:0051"(fluorescence technology)	Hausmann et al. (2008)	pubmed:18538672|imex:IM-14070|mint:MINT-6550998	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7963383|mint:MINT-6664499|imex:IM-14070-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR020791|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|mint:O27552|ensemblbacteria:AAB85983(transcript)|ensemblbacteria:MTH_1508(gene)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|mint:MINT-6664505(identity)	interpro:IPR017449(Prolyl-tRNA synthetase, class II)|interpro:IPR002316(Prolyl-tRNA synthetase, class IIa)|interpro:IPR016061(Prolyl-tRNA synthetase, class II, C-terminal)|interpro:IPR004499(Prolyl-tRNA synthetase, class IIa, prokaryotic-type)|interpro:IPR004154(Anticodon-binding)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR033721|mint:O26708|ensemblbacteria:AAB85117(transcript)|ensemblbacteria:MTH_611(gene)|go:"GO:0004827"(proline-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006433"(prolyl-tRNA aminoacylation)|go:"GO:0046872"(metal ion binding)|rcsb pdb:1NJ1|rcsb pdb:1NJ2|rcsb pdb:1NJ5|rcsb pdb:1NJ6|interpro:IPR036621|mint:MINT-6664501(identity)	-	comment:mint	function:"Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). Can inadvertently accommodate and process cysteine"|comment:mint	figure legend:t2|kinetics:kd 80 nanomolar|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/28	2014/10/16	rogid:rtE3wPOaBxN6j5QEC5j976nvPwo187420	rogid:1WYxQSxmAFC9qL3tg5p/POkquts187420	intact-crc:BF43A02A7820A418|rigid:42C8ttaM0VrSm1iZlRcYA9tAjHQ	false	his tag:?-?(MINT-6664508)|mutation disrupting interaction:890-937(MINT-6664590)	his tag:?-?(MINT-6664502)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O27552	uniprotkb:O27585	intact:EBI-7963108|intact:MINT-6551018|ensemblbacteria:AAB85983	intact:EBI-7963255|intact:MINT-6664477|ensemblbacteria:AAB86016	psi-mi:syl_metth(display_long)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym)|uniprotkb:MTH_1508(locus name)|uniprotkb:leuS(gene name)|psi-mi:leuS(display_short)	psi-mi:syk_metth(display_long)|uniprotkb:Lysyl-tRNA synthetase(gene name synonym)|uniprotkb:MTH_1542(locus name)|uniprotkb:lysS(gene name)|psi-mi:lysS(display_short)	psi-mi:"MI:0051"(fluorescence technology)	Hausmann et al. (2008)	pubmed:18538672|imex:IM-14070|mint:MINT-6550998	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7963406|mint:MINT-6664543|imex:IM-14070-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR020791|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|mint:O27552|ensemblbacteria:AAB85983(transcript)|ensemblbacteria:MTH_1508(gene)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|mint:MINT-6664549(identity)	interpro:IPR002904(Lysyl-tRNA synthetase, class Ic, archaeal)|interpro:IPR020751|interpro:IPR008925(Aminoacyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|mint:O27585|ensemblbacteria:AAB86016(transcript)|ensemblbacteria:MTH_1542(gene)|go:"GO:0000049"(tRNA binding)|go:"GO:0004824"(lysine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006430"(lysyl-tRNA aminoacylation)|mint:MINT-6664545(identity)	-	comment:mint	comment:mint	kinetics:kd 170 nanomolar|figure legend:t2|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/28	2014/10/16	rogid:rtE3wPOaBxN6j5QEC5j976nvPwo187420	rogid:4cySOY1XGWy3JNjPqzzrC9DxkGA187420	intact-crc:6E316147B8C63E76|rigid:sXjC4jK425DdDAD0iZRCEvIJAlc	false	his tag:?-?(MINT-6664552)	his tag:?-?(MINT-6664546)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O27552	uniprotkb:O27132	intact:EBI-7963108|intact:MINT-6551018|ensemblbacteria:AAB85983	intact:EBI-7963138|intact:MINT-6551005|ensemblbacteria:AAB85549	psi-mi:syl_metth(display_long)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym)|uniprotkb:MTH_1508(locus name)|uniprotkb:leuS(gene name)|psi-mi:leuS(display_short)	psi-mi:ef1a_metth(display_long)|uniprotkb:tuf(gene name)|psi-mi:tuf(display_short)|uniprotkb:MTH_1058(locus name)|uniprotkb:Elongation factor Tu(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Hausmann et al. (2008)	pubmed:18538672|imex:IM-14070|mint:MINT-6550998	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7963536|mint:MINT-6664610|imex:IM-14070-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR020791|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|mint:O27552|ensemblbacteria:AAB85983(transcript)|ensemblbacteria:MTH_1508(gene)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|mint:MINT-6664616(identity)	refseq:WP_010876684.1|interpro:IPR031157|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR005225(Small GTP-binding protein)|mint:O27132|ensemblbacteria:AAB85549(transcript)|ensemblbacteria:MTH_1058(gene)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|mint:MINT-6664612(identity)	-	comment:mint	comment:mint|function:This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	kinetics:kd 150 nanomolar|figure legend:t2|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/28	2014/10/16	rogid:rtE3wPOaBxN6j5QEC5j976nvPwo187420	rogid:vMP6Kz+xOg6in2KRBeBmmcXR6sk187420	intact-crc:F66AC118A74966E5|rigid:MDKnGE4Rl3Kod4rW3aNWN2r1a6A	false	his tag:?-?(MINT-6664619)|mutation decreasing interaction:890-937(MINT-6664617)	his tag:?-?(MINT-6664613)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O27552	uniprotkb:O27585	intact:EBI-7963108|intact:MINT-6551018|ensemblbacteria:AAB85983	intact:EBI-7963255|intact:MINT-6664477|ensemblbacteria:AAB86016	psi-mi:syl_metth(display_long)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym)|uniprotkb:MTH_1508(locus name)|uniprotkb:leuS(gene name)|psi-mi:leuS(display_short)	psi-mi:syk_metth(display_long)|uniprotkb:Lysyl-tRNA synthetase(gene name synonym)|uniprotkb:MTH_1542(locus name)|uniprotkb:lysS(gene name)|psi-mi:lysS(display_short)	psi-mi:"MI:0051"(fluorescence technology)	Hausmann et al. (2008)	pubmed:18538672|imex:IM-14070|mint:MINT-6550998	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7963513|mint:MINT-6664594|imex:IM-14070-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR020791|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|mint:O27552|ensemblbacteria:AAB85983(transcript)|ensemblbacteria:MTH_1508(gene)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|mint:MINT-6664600(identity)	interpro:IPR002904(Lysyl-tRNA synthetase, class Ic, archaeal)|interpro:IPR020751|interpro:IPR008925(Aminoacyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|mint:O27585|ensemblbacteria:AAB86016(transcript)|ensemblbacteria:MTH_1542(gene)|go:"GO:0000049"(tRNA binding)|go:"GO:0004824"(lysine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006430"(lysyl-tRNA aminoacylation)|mint:MINT-6664596(identity)	-	comment:mint	comment:mint	figure legend:t2|kinetics:kd 50 nanomolar|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/28	2014/10/16	rogid:rtE3wPOaBxN6j5QEC5j976nvPwo187420	rogid:4cySOY1XGWy3JNjPqzzrC9DxkGA187420	intact-crc:CDECD9F644C9557B|rigid:sXjC4jK425DdDAD0iZRCEvIJAlc	false	his tag:?-?(MINT-6664603)|mutation increasing interaction:1-8(MINT-6664601)	his tag:?-?(MINT-6664597)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O27552	uniprotkb:O26708	intact:EBI-7963108|intact:MINT-6551018|ensemblbacteria:AAB85983	intact:EBI-7963357|intact:MINT-6664518|ensemblbacteria:AAB85117	psi-mi:syl_metth(display_long)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym)|uniprotkb:MTH_1508(locus name)|uniprotkb:leuS(gene name)|psi-mi:leuS(display_short)	psi-mi:syp_metth(display_long)|uniprotkb:Prolyl-tRNA synthetase(gene name synonym)|uniprotkb:MTH_611(locus name)|uniprotkb:proS(gene name)|psi-mi:proS(display_short)	psi-mi:"MI:0051"(fluorescence technology)	Hausmann et al. (2008)	pubmed:18538672|imex:IM-14070|mint:MINT-6550998	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	taxid:187420(metth)|taxid:187420(Methanobacterium thermoautotrophicum)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7963447|mint:MINT-6664575|imex:IM-14070-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR020791|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|mint:O27552|ensemblbacteria:AAB85983(transcript)|ensemblbacteria:MTH_1508(gene)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|mint:MINT-6664577(identity)	interpro:IPR017449(Prolyl-tRNA synthetase, class II)|interpro:IPR002316(Prolyl-tRNA synthetase, class IIa)|interpro:IPR016061(Prolyl-tRNA synthetase, class II, C-terminal)|interpro:IPR004499(Prolyl-tRNA synthetase, class IIa, prokaryotic-type)|interpro:IPR004154(Anticodon-binding)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR033721|mint:O26708|ensemblbacteria:AAB85117(transcript)|ensemblbacteria:MTH_611(gene)|go:"GO:0004827"(proline-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006433"(prolyl-tRNA aminoacylation)|go:"GO:0046872"(metal ion binding)|rcsb pdb:1NJ1|rcsb pdb:1NJ2|rcsb pdb:1NJ5|rcsb pdb:1NJ6|interpro:IPR036621|mint:MINT-6664583(identity)	-	comment:mint	function:"Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). Can inadvertently accommodate and process cysteine"|comment:mint	figure legend:t2|kinetics:kd 110 nanomolar|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/28	2014/10/16	rogid:rtE3wPOaBxN6j5QEC5j976nvPwo187420	rogid:1WYxQSxmAFC9qL3tg5p/POkquts187420	intact-crc:E20C7F4BF11DD07D|rigid:42C8ttaM0VrSm1iZlRcYA9tAjHQ	false	his tag:?-?(MINT-6664580)|mutation decreasing interaction:196-422(MINT-6664578)	his tag:?-?(MINT-6664584)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)