#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B chebi:"CHEBI:15422" uniprotkb:Q4JC68 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" intact:EBI-1786146|ensemblbacteria:AAY79611 psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:xpd_sulac(display_long)|uniprotkb:Saci_0192(locus name) psi-mi:"MI:0880"(atpase assay) Fan et al. (2008) pubmed:18510924 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:330779(sulac)|taxid:330779("Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)") psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1786157 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR010614(DEAD2)|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|rcsb pdb:3CRV|rcsb pdb:3CRW|rcsb pdb:5H8C|refseq:WP_011277112.1|interpro:IPR027417|ensemblbacteria:AAY79611(transcript)|ensemblbacteria:Saci_0192(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity) go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0005524"(ATP binding) - - kinetics:ATP-hydrolysis rate = 0.55 mol ATP per second per mol Sulfolobus acidocaldarius XPD with single-stranded DNA.|figure legend:Fig. 4 Table 2|dataset:Archaea - Interaction dataset based on Archaea proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/30 2014/10/16 - rogid:94LOc6cDqgHbPf36YYdC3kDGvfc330779 intact-crc:349FF563B42D8C66 false - mutation disrupting interaction:34-34|mutation disrupting interaction:514-514|mutation decreasing interaction:180-180|mutation decreasing interaction:447-447|mutation decreasing interaction:531-531|mutation decreasing interaction:102-102|mutation decreasing interaction:56-56|mutation decreasing interaction:403-403|mutation decreasing interaction:88-88|mutation decreasing interaction:446-446|mutation decreasing interaction:523-523|mutation decreasing interaction:84-84|mutation decreasing interaction:438-438|mutation increasing interaction:521-521 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-1786244 intact:EBI-1786246 - - psi-mi:25mer_dna(display_short)|psi-mi:EBI-1786244(display_long) psi-mi:50mer_dna(display_short)|psi-mi:EBI-1786246(display_long) psi-mi:"MI:0415"(enzymatic study) Fan et al. (2008) pubmed:18510924 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0701"(dna strand elongation) psi-mi:"MI:0469"(IntAct) intact:EBI-1786248 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0319"(deoxyribonucleic acid) psi-mi:"MI:0319"(deoxyribonucleic acid) - - go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity) - - kinetics:Helicase assay rate = 2.22 base pairs per minute per molecule Sulfolobus acidocaldarius XPD.|figure legend:Fig. 4 Table 2, Supp. Fig. 6|inhibition:By an oxidising agent - ferricyanide|dataset:Archaea - Interaction dataset based on Archaea proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/30 2014/10/16 crc64:FBFD3E7533BD3F77 crc64:EB2F98151EC9B3FB intact-crc:DA37FDA007DA119A false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-1786244 uniprotkb:Q4JC68 - intact:EBI-1786146|ensemblbacteria:AAY79611 psi-mi:25mer_dna(display_short)|psi-mi:EBI-1786244(display_long) psi-mi:xpd_sulac(display_long)|uniprotkb:Saci_0192(locus name) psi-mi:"MI:0415"(enzymatic study) Fan et al. (2008) pubmed:18510924 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:330779(sulac)|taxid:330779("Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)") psi-mi:"MI:0701"(dna strand elongation) psi-mi:"MI:0469"(IntAct) intact:EBI-1786248 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0319"(deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR010614(DEAD2)|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|rcsb pdb:3CRV|rcsb pdb:3CRW|rcsb pdb:5H8C|refseq:WP_011277112.1|interpro:IPR027417|ensemblbacteria:AAY79611(transcript)|ensemblbacteria:Saci_0192(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity) go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity) - - kinetics:Helicase assay rate = 2.22 base pairs per minute per molecule Sulfolobus acidocaldarius XPD.|figure legend:Fig. 4 Table 2, Supp. Fig. 6|inhibition:By an oxidising agent - ferricyanide|dataset:Archaea - Interaction dataset based on Archaea proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/30 2014/10/16 crc64:FBFD3E7533BD3F77 rogid:94LOc6cDqgHbPf36YYdC3kDGvfc330779 intact-crc:DA37FDA007DA119A false - mutation disrupting interaction:34-34|mutation disrupting interaction:514-514|mutation decreasing interaction:180-180|mutation disrupting interaction:447-447|mutation disrupting interaction:531-531|mutation disrupting interaction:102-102|mutation decreasing interaction:56-56|mutation decreasing interaction:403-403|mutation decreasing interaction:88-88|mutation decreasing interaction:369-369|mutation decreasing interaction:446-446|mutation decreasing interaction:523-523|mutation decreasing interaction:84-84|mutation decreasing interaction:521-521 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:49883" uniprotkb:Q4JC68 intact:EBI-1802358 intact:EBI-1786146|ensemblbacteria:AAY79611 psi-mi:tetra-mu3-sulfido-tetrairon(display_short)|psi-mi:"CHEBI:49883"(display_long) psi-mi:xpd_sulac(display_long)|uniprotkb:Saci_0192(locus name) psi-mi:"MI:0114"(x-ray crystallography) Fan et al. (2008) pubmed:18510924 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:330779(sulac)|taxid:330779("Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1802396|wwpdb:3crv - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR010614(DEAD2)|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|rcsb pdb:3CRV|rcsb pdb:3CRW|rcsb pdb:5H8C|refseq:WP_011277112.1|interpro:IPR027417|ensemblbacteria:AAY79611(transcript)|ensemblbacteria:Saci_0192(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity) - - - figure legend:Fig. 1, Table 1|3d-resolution:2.0A|3d-r-factors:working 22.2%, free 26.0%|dataset:Archaea - Interaction dataset based on Archaea proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/30 2014/10/16 - rogid:94LOc6cDqgHbPf36YYdC3kDGvfc330779 intact-crc:25706BEC18967999 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)