#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9QXT5 uniprotkb:P28301 intact:EBI-7935472|uniprotkb:Q9DCP5|uniprotkb:Q6XD35|intact:UNK-5553849|ensembl:ENSMUSP00000099971|ensembl:ENSMUSP00000115482|ensembl:ENSMUSP00000128741|ensembl:ENSMUSP00000159032 intact:EBI-642911|ensembl:ENSMUSP00000025409|ensembl:ENSMUSP00000129247 psi-mi:egfl7_mouse(display_long)|uniprotkb:Egfl7(gene name)|psi-mi:Egfl7(display_short)|uniprotkb:Megf7(gene name synonym)|uniprotkb:Multiple epidermal growth factor-like domains protein 7(gene name synonym)|uniprotkb:Vascular endothelial statin(gene name synonym)|uniprotkb:NOTCH4-like protein(gene name synonym)|uniprotkb:Zneu1(gene name synonym) psi-mi:lyox_mouse(display_long)|uniprotkb:Lysyl oxidase(gene name synonym)|uniprotkb:Ras excision protein(gene name synonym)|uniprotkb:Lox(gene name)|psi-mi:Lox(display_short)|uniprotkb:Rrg(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lelièvre et al. (2008) pubmed:18497746|imex:IM-14063|mint:MINT-6743479 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7935503|mint:MINT-6743487|imex:IM-14063-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001158036.1|refseq:NP_848538.3|refseq:NP_942018.2|refseq:NP_942017.2|ensembl:ENSMUSG00000026921(gene)|ensembl:ENSMUST00000102907(transcript)|ensembl:ENSMUST00000150404(transcript)|ensembl:ENSMUST00000166920(transcript)|ensembl:ENSMUST00000239075(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR011489(EMI)|interpro:IPR018097|mint:Q9QXT5|mint:MINT-6743490(identity) refseq:NP_001273110.1|refseq:NP_001273111.1|refseq:NP_034858.2|ensembl:ENSMUSG00000024529(gene)|ensembl:ENSMUST00000025409(transcript)|ensembl:ENSMUST00000171470(transcript)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035904"(aorta development)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0001568"(blood vessel development)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0009725"(response to hormone)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0018158"(protein oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|interpro:IPR019828|mint:P28301|reactome:R-MMU-1566948|reactome:R-MMU-2243919|mint:MINT-6743489(identity) - comment:mint|function:"Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro" - figure legend:f6b f6c|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells) - 2008/09/15 2014/10/16 rogid:6Y6KB4j+AVLhLHHWW6SZnVzZzUc10090 rogid:ehv+lVMTVIzWWWxaRlO+aIY53jk10090 intact-crc:8E12A18DB91F8851|rigid:yT5ilHAaa2Vnc+I1B0NLYrh8hD8 false ha tag:?-?(MINT-6743501) binding-associated region:207-411(MINT-6743497)|flag tag:?-?(MINT-6743494) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9QXT5 uniprotkb:P97873 intact:EBI-7935472|uniprotkb:Q9DCP5|uniprotkb:Q6XD35|intact:UNK-5553849|ensembl:ENSMUSP00000099971|ensembl:ENSMUSP00000115482|ensembl:ENSMUSP00000128741|ensembl:ENSMUSP00000159032 intact:EBI-7935532|uniprotkb:Q99KX3|intact:MINT-6743519|uniprotkb:Q91ZY4 psi-mi:egfl7_mouse(display_long)|uniprotkb:Egfl7(gene name)|psi-mi:Egfl7(display_short)|uniprotkb:Megf7(gene name synonym)|uniprotkb:Multiple epidermal growth factor-like domains protein 7(gene name synonym)|uniprotkb:Vascular endothelial statin(gene name synonym)|uniprotkb:NOTCH4-like protein(gene name synonym)|uniprotkb:Zneu1(gene name synonym) psi-mi:loxl1_mouse(display_long)|uniprotkb:Loxl1(gene name)|psi-mi:Loxl1(display_short)|uniprotkb:Lox2(gene name synonym)|uniprotkb:Loxl(gene name synonym)|uniprotkb:Lysyl oxidase-like protein 1(gene name synonym)|uniprotkb:Lysyl oxidase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lelièvre et al. (2008) pubmed:18497746|imex:IM-14063|mint:MINT-6743479 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7935526|mint:MINT-6743505|imex:IM-14063-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001158036.1|refseq:NP_848538.3|refseq:NP_942018.2|refseq:NP_942017.2|ensembl:ENSMUSG00000026921(gene)|ensembl:ENSMUST00000102907(transcript)|ensembl:ENSMUST00000150404(transcript)|ensembl:ENSMUST00000166920(transcript)|ensembl:ENSMUST00000239075(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR011489(EMI)|interpro:IPR018097|mint:Q9QXT5|mint:MINT-6743514(identity) interpro:IPR001695(Lysyl oxidase)|refseq:NP_034859.2|interpro:IPR019828|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016641"(oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0062023"(collagen-containing extracellular matrix)|reactome:R-MMU-1566948|reactome:R-MMU-2243919|go:"GO:0005615"(extracellular space)|go:"GO:0005604"(basement membrane)|mint:P97873|mint:MINT-6743507(identity) - comment:mint|function:"Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro" function:Active on elastin and collagen substrates|comment:mint figure legend:f6b f6c|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells) - 2008/09/15 2014/10/16 rogid:6Y6KB4j+AVLhLHHWW6SZnVzZzUc10090 rogid:FRQSGUwMWBvmrr6+6yDeABc6U2010090 intact-crc:1A3FA94523AE0F52|rigid:ONIH6xAGZnoXaKqE9uPJLB6d8Qc false ha tag:?-?(MINT-6743515) binding-associated region:403-607(MINT-6743508)|flag tag:?-?(MINT-6743511) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Z175 uniprotkb:Q9QXT5 intact:EBI-7935624|uniprotkb:Q9JJ39|uniprotkb:Q91VN8|intact:UNK-5561317|ensembl:ENSMUSP00000000707 intact:EBI-7935472|uniprotkb:Q9DCP5|uniprotkb:Q6XD35|intact:UNK-5553849|ensembl:ENSMUSP00000099971|ensembl:ENSMUSP00000115482|ensembl:ENSMUSP00000128741|ensembl:ENSMUSP00000159032 psi-mi:loxl3_mouse(display_long)|uniprotkb:Loxl3(gene name)|psi-mi:Loxl3(display_short)|uniprotkb:Lor2(gene name synonym)|uniprotkb:Lysyl oxidase-like protein 3(gene name synonym)|uniprotkb:Lysyl oxidase-related protein 2(gene name synonym) psi-mi:egfl7_mouse(display_long)|uniprotkb:Egfl7(gene name)|psi-mi:Egfl7(display_short)|uniprotkb:Megf7(gene name synonym)|uniprotkb:Multiple epidermal growth factor-like domains protein 7(gene name synonym)|uniprotkb:Vascular endothelial statin(gene name synonym)|uniprotkb:NOTCH4-like protein(gene name synonym)|uniprotkb:Zneu1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lelièvre et al. (2008) pubmed:18497746|imex:IM-14063|mint:MINT-6743479 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7935618|mint:MINT-6743586|imex:IM-14063-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038614.2|ensembl:ENSMUSG00000000693(gene)|ensembl:ENSMUST00000000707(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001968"(fibronectin binding)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0021510"(spinal cord development)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030324"(lung development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061053"(somite development)|go:"GO:1905590"(fibronectin fibril organization)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR019828|interpro:IPR036772|mint:Q9Z175|reactome:R-MMU-1566948|reactome:R-MMU-2243919|go:"GO:0006954"(inflammatory response)|mint:MINT-6743588(identity) refseq:NP_001158036.1|refseq:NP_848538.3|refseq:NP_942018.2|refseq:NP_942017.2|ensembl:ENSMUSG00000026921(gene)|ensembl:ENSMUST00000102907(transcript)|ensembl:ENSMUST00000150404(transcript)|ensembl:ENSMUST00000166920(transcript)|ensembl:ENSMUST00000239075(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR011489(EMI)|interpro:IPR018097|mint:Q9QXT5|mint:MINT-6743595(identity) - comment:mint comment:mint|function:"Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro" figure legend:f6b f6c|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells) - 2008/09/15 2014/10/16 rogid:Uy9YsJRZZBcT1urV3tiuaG2LWlE10090 rogid:6Y6KB4j+AVLhLHHWW6SZnVzZzUc10090 intact-crc:942F1CDB3F2CABC0|rigid:NI42Fjs4kbGofINpxIj6zvJqMV4 false flag tag:?-?(MINT-6743592)|binding-associated region:530-733(MINT-6743589) ha tag:?-?(MINT-6743596) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9QXT5 uniprotkb:P58022-2 intact:EBI-7935472|uniprotkb:Q9DCP5|uniprotkb:Q6XD35|intact:UNK-5553849|ensembl:ENSMUSP00000099971|ensembl:ENSMUSP00000115482|ensembl:ENSMUSP00000128741|ensembl:ENSMUSP00000159032 intact:EBI-7935577|intact:MINT-6743570 psi-mi:egfl7_mouse(display_long)|uniprotkb:Egfl7(gene name)|psi-mi:Egfl7(display_short)|uniprotkb:Megf7(gene name synonym)|uniprotkb:Multiple epidermal growth factor-like domains protein 7(gene name synonym)|uniprotkb:Vascular endothelial statin(gene name synonym)|uniprotkb:NOTCH4-like protein(gene name synonym)|uniprotkb:Zneu1(gene name synonym) psi-mi:p58022-2(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lelièvre et al. (2008) pubmed:18497746|imex:IM-14063|mint:MINT-6743479 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7935571|mint:MINT-6743537|imex:IM-14063-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001158036.1|refseq:NP_848538.3|refseq:NP_942018.2|refseq:NP_942017.2|ensembl:ENSMUSG00000026921(gene)|ensembl:ENSMUST00000102907(transcript)|ensembl:ENSMUST00000150404(transcript)|ensembl:ENSMUST00000166920(transcript)|ensembl:ENSMUST00000239075(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR011489(EMI)|interpro:IPR018097|mint:Q9QXT5|mint:MINT-6743546(identity) mint:MINT-6743551(isoform-parent)|mint:MINT-6743539(identity) - comment:mint|function:"Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro" comment:mint|isoform-comment:No experimental confirmation available figure legend:f6b f6c|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells) - 2008/09/15 2014/10/16 rogid:6Y6KB4j+AVLhLHHWW6SZnVzZzUc10090 rogid:Hq8cCo9VhKhF433dASruhEYcFi810090 intact-crc:C7CEDADE1F209A1E|rigid:0TJKdL/ySiSGa9UJdlIpLfR/7oU false ha tag:?-?(MINT-6743547) binding-associated region:550-727(MINT-6743542)|flag tag:?-?(MINT-6743540) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9QXT5 uniprotkb:Q924C6 intact:EBI-7935472|uniprotkb:Q9DCP5|uniprotkb:Q6XD35|intact:UNK-5553849|ensembl:ENSMUSP00000099971|ensembl:ENSMUSP00000115482|ensembl:ENSMUSP00000128741|ensembl:ENSMUSP00000159032 intact:EBI-7935666|intact:UNK-5532281|uniprotkb:E9PXI3|ensembl:ENSMUSP00000026190|ensembl:ENSMUSP00000126686 psi-mi:egfl7_mouse(display_long)|uniprotkb:Egfl7(gene name)|psi-mi:Egfl7(display_short)|uniprotkb:Megf7(gene name synonym)|uniprotkb:Multiple epidermal growth factor-like domains protein 7(gene name synonym)|uniprotkb:Vascular endothelial statin(gene name synonym)|uniprotkb:NOTCH4-like protein(gene name synonym)|uniprotkb:Zneu1(gene name synonym) psi-mi:loxl4_mouse(display_long)|uniprotkb:Loxl4(gene name)|psi-mi:Loxl4(display_short)|uniprotkb:Loxc(gene name synonym)|uniprotkb:Lysyl oxidase-like protein 4(gene name synonym)|uniprotkb:Lysyl oxidase-related protein C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lelièvre et al. (2008) pubmed:18497746|imex:IM-14063|mint:MINT-6743479 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7935690|mint:MINT-6743602|imex:IM-14063-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001158036.1|refseq:NP_848538.3|refseq:NP_942018.2|refseq:NP_942017.2|ensembl:ENSMUSG00000026921(gene)|ensembl:ENSMUST00000102907(transcript)|ensembl:ENSMUST00000150404(transcript)|ensembl:ENSMUST00000166920(transcript)|ensembl:ENSMUST00000239075(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR011489(EMI)|interpro:IPR018097|mint:Q9QXT5|mint:MINT-6743611(identity) refseq:NP_444313.3|ensembl:ENSMUSG00000025185(gene)|ensembl:ENSMUST00000026190(transcript)|ensembl:ENSMUST00000171432(transcript)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0016020"(membrane)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0043235"(receptor complex)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR019828|interpro:IPR036772|mint:Q924C6|reactome:R-MMU-1566948|reactome:R-MMU-2243919|mint:MINT-6743604(identity) - comment:mint|function:"Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro" comment:mint|function:May modulate the formation of a collagenous extracellular matrix figure legend:f6b f6c|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells) - 2008/09/15 2014/10/16 rogid:6Y6KB4j+AVLhLHHWW6SZnVzZzUc10090 rogid:0YLsHZkoLADBlg0DtMJPhwwL7z010090 intact-crc:52A8685B67E81890|rigid:gRK8Noopb7zY2xnDN7gtKMhWV7k false ha tag:?-?(MINT-6743612) flag tag:?-?(MINT-6743605)|binding-associated region:?-?(MINT-6743607) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Y4K0 uniprotkb:Q9UHF1 intact:EBI-7172227|ensembl:ENSP00000373783|intact:MINT-4053647|uniprotkb:Q9BW70|uniprotkb:Q53HV3|uniprotkb:Q9Y5Y8|uniprotkb:B2R5Q0 intact:EBI-949532|ensembl:ENSP00000307843|ensembl:ENSP00000360763|ensembl:ENSP00000360764|ensembl:ENSP00000385639|uniprotkb:Q5M7Y5|uniprotkb:Q5VUD5|uniprotkb:Q96EG0|uniprotkb:B3KRP0|uniprotkb:M9VTX9 psi-mi:loxl2_human(display_long)|uniprotkb:LOXL2(gene name)|psi-mi:LOXL2(display_short)|uniprotkb:Lysyl oxidase-like protein 2(gene name synonym)|uniprotkb:Lysyl oxidase-related protein 2(gene name synonym)|uniprotkb:Lysyl oxidase-related protein WS9-14(gene name synonym) psi-mi:egfl7_human(display_long)|uniprotkb:Multiple epidermal growth factor-like domains protein 7(gene name synonym)|uniprotkb:Zneu1(gene name synonym)|uniprotkb:Vascular endothelial statin(gene name synonym)|uniprotkb:NOTCH4-like protein(gene name synonym)|uniprotkb:EGFL7(gene name)|psi-mi:EGFL7(display_short)|uniprotkb:MEGF7(gene name synonym)|uniprotkb:UNQ187/PRO1449(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Lelièvre et al. (2008) pubmed:18497746|imex:IM-14063|mint:MINT-6743479 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7935727|mint:MINT-6743620|imex:IM-14063-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000134013(gene)|ensembl:ENST00000389131(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007155"(cell adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0007568"(aging)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016020"(membrane)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046688"(response to copper ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070492"(oligosaccharide binding)|go:"GO:0070828"(heterochromatin organization)|go:"GO:1902455"(negative regulation of stem cell population maintenance)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR019828|interpro:IPR036772|mint:Q9Y4K0|rcsb pdb:5ZE3|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0030199"(collagen fibril organization)|refseq:NP_002309.1|mint:MINT-6743622(identity) ensembl:ENSG00000172889(gene)|ensembl:ENST00000308874(transcript)|ensembl:ENST00000371698(transcript)|ensembl:ENST00000371699(transcript)|ensembl:ENST00000406555(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011489(EMI)|interpro:IPR013111(EGF, extracellular)|interpro:IPR018097|mint:Q9UHF1|go:"GO:0005576"(extracellular region)|refseq:NP_057299.1|refseq:NP_958854.1|refseq:XP_011517066.1|refseq:XP_011517067.1|refseq:XP_011517068.1|mint:MINT-6743629(identity) go:"GO:0031012"(extracellular matrix) comment:mint - figure legend:f7e|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)") - 2008/09/15 2014/10/16 rogid:F7xjdY5T+JdpyIAsi2BmXPzqz+A9606 rogid:HzaJXQm4JE8bXXE+/ugmqGjpjZA9606 intact-crc:F7E8BC4E1157AD6A|rigid:GPX0jibWtuyMUm6DGcExIlW0rr8 false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)