#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9R078	uniprotkb:O54950	intact:EBI-2366248|uniprotkb:Q91YN6|ensembl:ENSMUSP00000031486|ensembl:ENSMUSP00000107630	intact:EBI-7927886|uniprotkb:Q5PRE8|intact:MINT-4583597|ensembl:ENSMUSP00000132499	psi-mi:aakb1_mouse(display_long)|uniprotkb:Prkab1(gene name)|psi-mi:Prkab1(display_short)	psi-mi:aakg1_mouse(display_long)|uniprotkb:Prkag1(gene name)|psi-mi:Prkag1(display_short)|uniprotkb:Prkaac(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7927879|mint:MINT-6767413|imex:IM-11626-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114075.1|refseq:XP_006530264.1|ensembl:ENSMUSG00000029513(gene)|ensembl:ENSMUST00000031486(transcript)|ensembl:ENSMUST00000111999(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9R078|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|mint:MINT-6767415(identity)	refseq:NP_058061.2|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043531"(ADP binding)|ensembl:ENSMUSG00000067713(gene)|ensembl:ENSMUST00000168846(transcript)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|mint:O54950|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|mint:MINT-6767416(identity)	go:"GO:0005783"(endoplasmic reticulum)	-	comment:mint|function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit	figure legend:F2A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bat)|taxid:10090(Mus musculus)	-	2008/09/19	2014/10/16	rogid:FutyYXgmMYBa1yaSlduxfVqV7z410090	rogid:QbsRkFjF/c8PqK9DB5D637VeMzc10090	intact-crc:946165924B7DEF54|rigid:BFjX0X5nRS0462hBr6PcHbromx4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9R078	uniprotkb:O70302	intact:EBI-2366248|uniprotkb:Q91YN6|ensembl:ENSMUSP00000031486|ensembl:ENSMUSP00000107630	intact:EBI-7927848|intact:UNK-5365136|uniprotkb:Q4V9X2|ensembl:ENSMUSP00000025404	psi-mi:aakb1_mouse(display_long)|uniprotkb:Prkab1(gene name)|psi-mi:Prkab1(display_short)	psi-mi:cidea_mouse(display_long)|uniprotkb:Cidea(gene name)|psi-mi:Cidea(display_short)|uniprotkb:Cell death-inducing DFFA-like effector A(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7927879|mint:MINT-6767413|imex:IM-11626-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114075.1|refseq:XP_006530264.1|ensembl:ENSMUSG00000029513(gene)|ensembl:ENSMUST00000031486(transcript)|ensembl:ENSMUST00000111999(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9R078|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|mint:MINT-6767415(identity)	refseq:NP_031728.2|go:"GO:0008219"(cell death)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0019915"(lipid storage)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0070417"(cellular response to cold)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR032936|mint:O70302|reactome:R-MMU-8964572|go:"GO:0006915"(apoptotic process)|ensembl:ENSMUSG00000024526(gene)|ensembl:ENSMUST00000025404(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005811"(lipid droplet)|go:"GO:0006629"(lipid metabolic process)|mint:MINT-6767417(identity)	go:"GO:0005783"(endoplasmic reticulum)	-	comment:mint|function:Activates apoptosis	figure legend:F2A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bat)|taxid:10090(Mus musculus)	-	2008/09/19	2014/10/16	rogid:FutyYXgmMYBa1yaSlduxfVqV7z410090	rogid:w5xZdqvm/6mXDm8UEg4ecuqJhUQ10090	intact-crc:946165924B7DEF54|rigid:BFjX0X5nRS0462hBr6PcHbromx4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9R078	uniprotkb:P19783	intact:EBI-2366248|uniprotkb:Q91YN6|ensembl:ENSMUSP00000031486|ensembl:ENSMUSP00000107630	intact:EBI-7174084|ensembl:ENSMUSP00000034276|ensembl:ENSMUSP00000138019|uniprotkb:Q545A9|intact:MINT-1860013	psi-mi:aakb1_mouse(display_long)|uniprotkb:Prkab1(gene name)|psi-mi:Prkab1(display_short)	psi-mi:cox41_mouse(display_long)|uniprotkb:Cox4i1(gene name)|psi-mi:Cox4i1(display_short)|uniprotkb:Cox4(gene name synonym)|uniprotkb:Cox4a(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7927879|mint:MINT-6767413|imex:IM-11626-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114075.1|refseq:XP_006530264.1|ensembl:ENSMUSG00000029513(gene)|ensembl:ENSMUST00000031486(transcript)|ensembl:ENSMUST00000111999(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9R078|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|mint:MINT-6767415(identity)	refseq:NP_001280488.1|refseq:NP_034071.2|ensembl:ENSMUSG00000031818(gene)|ensembl:ENSMUST00000034276(transcript)|ensembl:ENSMUST00000181586(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031966"(mitochondrial membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P19783|reactome:R-MMU-5628897|reactome:R-MMU-611105|reactome:R-MMU-9707564|mint:MINT-6767419(identity)	go:"GO:0005783"(endoplasmic reticulum)	-	function:This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport|comment:mint	figure legend:F2A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bat)|taxid:10090(Mus musculus)	-	2008/09/19	2014/10/16	rogid:FutyYXgmMYBa1yaSlduxfVqV7z410090	rogid:zt2qwV/jVAo1B9UISW8R2votzlU10090	intact-crc:946165924B7DEF54|rigid:BFjX0X5nRS0462hBr6PcHbromx4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9R078	uniprotkb:P09103	intact:EBI-2366248|uniprotkb:Q91YN6|ensembl:ENSMUSP00000031486|ensembl:ENSMUSP00000107630	intact:EBI-494709|uniprotkb:Q922C8|ensembl:ENSMUSP00000026122	psi-mi:aakb1_mouse(display_long)|uniprotkb:Prkab1(gene name)|psi-mi:Prkab1(display_short)	psi-mi:pdia1_mouse(display_long)|uniprotkb:Prolyl 4-hydroxylase subunit beta(gene name synonym)|uniprotkb:Cellular thyroid hormone-binding protein(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 59(gene name synonym)|uniprotkb:P4hb(gene name)|psi-mi:P4hb(display_short)|uniprotkb:Pdia1(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7927879|mint:MINT-6767413|imex:IM-11626-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114075.1|refseq:XP_006530264.1|ensembl:ENSMUSG00000029513(gene)|ensembl:ENSMUST00000031486(transcript)|ensembl:ENSMUST00000111999(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9R078|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|mint:MINT-6767415(identity)	refseq:NP_035162.1|ensembl:ENSMUSG00000025130(gene)|ensembl:ENSMUST00000026122(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003779"(actin binding)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P09103|reactome:R-MMU-1650814|reactome:R-MMU-3299685|reactome:R-MMU-381426|reactome:R-MMU-5358346|reactome:R-MMU-8866423|reactome:R-MMU-8957275|reactome:R-MMU-8963888|reactome:R-MMU-9020591|reactome:R-MMU-9020933|mint:MINT-6767418(identity)	go:"GO:0005783"(endoplasmic reticulum)	-	-	figure legend:F2A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bat)|taxid:10090(Mus musculus)	-	2008/09/19	2014/10/16	rogid:FutyYXgmMYBa1yaSlduxfVqV7z410090	rogid:j20LBPF1r9AYUdJAgzNS/+Uq8GY10090	intact-crc:946165924B7DEF54|rigid:BFjX0X5nRS0462hBr6PcHbromx4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70302	uniprotkb:Q3TDX8	intact:EBI-7927848|intact:UNK-5365136|uniprotkb:Q4V9X2|ensembl:ENSMUSP00000025404	intact:EBI-7928047|uniprotkb:Q6VXY4|uniprotkb:Q8BTI5|uniprotkb:Q3U012|uniprotkb:Q8BJV8|intact:UNK-5537179|uniprotkb:Q3TJH3|uniprotkb:Q6VXY5|uniprotkb:E9Q129|uniprotkb:Q8R3H8|uniprotkb:Q99LY4|uniprotkb:Q99P29|ensembl:ENSMUSP00000126119	psi-mi:cidea_mouse(display_long)|uniprotkb:Cidea(gene name)|psi-mi:Cidea(display_short)|uniprotkb:Cell death-inducing DFFA-like effector A(gene name synonym)	psi-mi:nb5r4_mouse(display_long)|uniprotkb:Cyb5r4(gene name)|psi-mi:Cyb5r4(display_short)|uniprotkb:Ncb5or(gene name synonym)|uniprotkb:Flavohemoprotein b5/b5R(gene name synonym)|uniprotkb:cb5/cb5R(gene name synonym)|uniprotkb:N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928040|mint:MINT-6768062|imex:IM-11626-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031728.2|go:"GO:0008219"(cell death)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0019915"(lipid storage)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0070417"(cellular response to cold)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR032936|mint:O70302|reactome:R-MMU-8964572|go:"GO:0006915"(apoptotic process)|ensembl:ENSMUSG00000024526(gene)|ensembl:ENSMUST00000025404(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005811"(lipid droplet)|go:"GO:0006629"(lipid metabolic process)|mint:MINT-6768064(identity)	refseq:NP_077157.2|refseq:XP_006511262.1|ensembl:ENSMUSG00000032872(gene)|ensembl:ENSMUST00000168529(transcript)|go:"GO:0003958"(NADPH-hemoprotein reductase activity)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|interpro:IPR001199(Cytochrome b5)|go:"GO:0030073"(insulin secretion)|go:"GO:0042168"(heme metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0046677"(response to antibiotic)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001834("NADH:cytochrome b5 reductase (CBR)")|interpro:IPR007052(CS domain)|interpro:IPR008333(Oxidoreductase FAD-binding region)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR017927|interpro:IPR017938|interpro:IPR018506|interpro:IPR036400|interpro:IPR037908|interpro:IPR039261|mint:Q3TDX8|reactome:R-MMU-1237044|go:"GO:0046872"(metal ion binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|mint:MINT-6768065(identity)	go:"GO:0005783"(endoplasmic reticulum)	comment:mint|function:Activates apoptosis	comment:mint|function:"NADH-cytochrome b5 reductase involved in endolasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS)"	figure legend:F2B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2008/09/19	2014/10/16	rogid:w5xZdqvm/6mXDm8UEg4ecuqJhUQ10090	rogid:j19wK584v3ZVxPwALGRiJ1DnnvU10090	intact-crc:DC35D46F4DDEE0A3|rigid:eJfcS0raizSdNyy8GqJmGAnPDKA	false	ha tag:?-?(MINT-6768073)	green fluorescent protein tag:?-?(MINT-6768069)	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O70302	uniprotkb:Q9Y478	intact:EBI-7927848|intact:UNK-5365136|uniprotkb:Q4V9X2|ensembl:ENSMUSP00000025404	intact:EBI-719769|uniprotkb:Q9UBV0|uniprotkb:Q9UE20|uniprotkb:Q9UEX2|uniprotkb:Q9Y6V8|ensembl:ENSP00000229328|ensembl:ENSP00000441369	psi-mi:cidea_mouse(display_long)|uniprotkb:Cidea(gene name)|psi-mi:Cidea(display_short)|uniprotkb:Cell death-inducing DFFA-like effector A(gene name synonym)	psi-mi:aakb1_human(display_long)|uniprotkb:PRKAB1(gene name)|psi-mi:PRKAB1(display_short)|uniprotkb:AMPK(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928230|mint:MINT-6768091|imex:IM-11626-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031728.2|go:"GO:0008219"(cell death)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0019915"(lipid storage)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0070417"(cellular response to cold)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR032936|mint:O70302|reactome:R-MMU-8964572|go:"GO:0006915"(apoptotic process)|ensembl:ENSMUSG00000024526(gene)|ensembl:ENSMUST00000025404(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005811"(lipid droplet)|go:"GO:0006629"(lipid metabolic process)|mint:MINT-6768098(identity)	refseq:NP_006244.2|ensembl:ENSG00000111725(gene)|ensembl:ENST00000229328(transcript)|ensembl:ENST00000541640(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9Y478|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|go:"GO:0005654"(nucleoplasm)|refseq:XP_005253966.1|dip:DIP-39736N|mint:MINT-6768094(identity)	go:"GO:0005783"(endoplasmic reticulum)	comment:mint|function:Activates apoptosis	-	figure legend:F2B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2008/09/19	2014/10/16	rogid:w5xZdqvm/6mXDm8UEg4ecuqJhUQ10090	rogid:QJftPEDhjfudQn6uXn5nWOkchc09606	intact-crc:5E27EECC10B4F627|rigid:4doKhZNnDJU8lebe6q9jc2lkblo	false	green fluorescent protein tag:?-?(MINT-6768099)	ha tag:?-?(MINT-6768095)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O70302	uniprotkb:Q9Y478	intact:EBI-7927848|intact:UNK-5365136|uniprotkb:Q4V9X2|ensembl:ENSMUSP00000025404	intact:EBI-719769|uniprotkb:Q9UBV0|uniprotkb:Q9UE20|uniprotkb:Q9UEX2|uniprotkb:Q9Y6V8|ensembl:ENSP00000229328|ensembl:ENSP00000441369	psi-mi:cidea_mouse(display_long)|uniprotkb:Cidea(gene name)|psi-mi:Cidea(display_short)|uniprotkb:Cell death-inducing DFFA-like effector A(gene name synonym)	psi-mi:aakb1_human(display_long)|uniprotkb:PRKAB1(gene name)|psi-mi:PRKAB1(display_short)|uniprotkb:AMPK(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928171|mint:MINT-6768077|imex:IM-11626-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031728.2|go:"GO:0008219"(cell death)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0019915"(lipid storage)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0070417"(cellular response to cold)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR032936|mint:O70302|reactome:R-MMU-8964572|go:"GO:0006915"(apoptotic process)|ensembl:ENSMUSG00000024526(gene)|ensembl:ENSMUST00000025404(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005811"(lipid droplet)|go:"GO:0006629"(lipid metabolic process)|mint:MINT-6768084(identity)	refseq:NP_006244.2|ensembl:ENSG00000111725(gene)|ensembl:ENST00000229328(transcript)|ensembl:ENST00000541640(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9Y478|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|go:"GO:0005654"(nucleoplasm)|refseq:XP_005253966.1|dip:DIP-39736N|mint:MINT-6768080(identity)	go:"GO:0005783"(endoplasmic reticulum)	comment:mint|function:Activates apoptosis	-	figure legend:F2B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2008/09/19	2014/10/16	rogid:w5xZdqvm/6mXDm8UEg4ecuqJhUQ10090	rogid:QJftPEDhjfudQn6uXn5nWOkchc09606	intact-crc:9888EA1E6AC136DB|rigid:4doKhZNnDJU8lebe6q9jc2lkblo	false	flag tag:?-?(MINT-6768085)	ha tag:?-?(MINT-6768081)	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O54950	uniprotkb:O70302	intact:EBI-7927886|uniprotkb:Q5PRE8|intact:MINT-4583597|ensembl:ENSMUSP00000132499	intact:EBI-7927848|intact:UNK-5365136|uniprotkb:Q4V9X2|ensembl:ENSMUSP00000025404	psi-mi:aakg1_mouse(display_long)|uniprotkb:Prkag1(gene name)|psi-mi:Prkag1(display_short)|uniprotkb:Prkaac(gene name synonym)	psi-mi:cidea_mouse(display_long)|uniprotkb:Cidea(gene name)|psi-mi:Cidea(display_short)|uniprotkb:Cell death-inducing DFFA-like effector A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928346|mint:MINT-6768581|imex:IM-11626-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058061.2|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043531"(ADP binding)|ensembl:ENSMUSG00000067713(gene)|ensembl:ENSMUST00000168846(transcript)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|mint:O54950|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|mint:MINT-6768583(identity)	refseq:NP_031728.2|go:"GO:0008219"(cell death)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0019915"(lipid storage)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0070417"(cellular response to cold)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR032936|mint:O70302|reactome:R-MMU-8964572|go:"GO:0006915"(apoptotic process)|ensembl:ENSMUSG00000024526(gene)|ensembl:ENSMUST00000025404(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005811"(lipid droplet)|go:"GO:0006629"(lipid metabolic process)|mint:MINT-6768589(identity)	-	comment:mint|function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit	comment:mint|function:Activates apoptosis	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2008/09/19	2014/10/16	rogid:QbsRkFjF/c8PqK9DB5D637VeMzc10090	rogid:w5xZdqvm/6mXDm8UEg4ecuqJhUQ10090	intact-crc:B2A6E3D271D9D8C3|rigid:LZQfNkQV7Nxvdp5h32EtFkOtfgs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O54950	uniprotkb:Q5EG47	intact:EBI-7927886|uniprotkb:Q5PRE8|intact:MINT-4583597|ensembl:ENSMUSP00000132499	intact:EBI-7282395|intact:UNK-5438461|ensembl:ENSMUSP00000063166	psi-mi:aakg1_mouse(display_long)|uniprotkb:Prkag1(gene name)|psi-mi:Prkag1(display_short)|uniprotkb:Prkaac(gene name synonym)	psi-mi:aapk1_mouse(display_long)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Prkaa1(gene name)|psi-mi:Prkaa1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928346|mint:MINT-6768581|imex:IM-11626-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058061.2|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043531"(ADP binding)|ensembl:ENSMUSG00000067713(gene)|ensembl:ENSMUST00000168846(transcript)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|mint:O54950|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|mint:MINT-6768583(identity)	refseq:NP_001013385.3|ensembl:ENSMUSG00000050697(gene)|ensembl:ENSMUST00000051186(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q5EG47|rcsb pdb:5UFU|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|dip:DIP-47622N|mint:MINT-6768585(identity)	-	comment:mint|function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit	function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit|comment:mint|comment:homomint	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2008/09/19	2014/10/16	rogid:QbsRkFjF/c8PqK9DB5D637VeMzc10090	rogid:9VI1u7JfAe+OsB+ncOxDv5ujYuE10090	intact-crc:B2A6E3D271D9D8C3|rigid:LZQfNkQV7Nxvdp5h32EtFkOtfgs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O54950	uniprotkb:Q9R078	intact:EBI-7927886|uniprotkb:Q5PRE8|intact:MINT-4583597|ensembl:ENSMUSP00000132499	intact:EBI-2366248|uniprotkb:Q91YN6|ensembl:ENSMUSP00000031486|ensembl:ENSMUSP00000107630	psi-mi:aakg1_mouse(display_long)|uniprotkb:Prkag1(gene name)|psi-mi:Prkag1(display_short)|uniprotkb:Prkaac(gene name synonym)	psi-mi:aakb1_mouse(display_long)|uniprotkb:Prkab1(gene name)|psi-mi:Prkab1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928346|mint:MINT-6768581|imex:IM-11626-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058061.2|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043531"(ADP binding)|ensembl:ENSMUSG00000067713(gene)|ensembl:ENSMUST00000168846(transcript)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|mint:O54950|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|mint:MINT-6768583(identity)	refseq:NP_114075.1|refseq:XP_006530264.1|ensembl:ENSMUSG00000029513(gene)|ensembl:ENSMUST00000031486(transcript)|ensembl:ENSMUST00000111999(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9R078|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|mint:MINT-6768587(identity)	-	comment:mint|function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit	-	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2008/09/19	2014/10/16	rogid:QbsRkFjF/c8PqK9DB5D637VeMzc10090	rogid:FutyYXgmMYBa1yaSlduxfVqV7z410090	intact-crc:B2A6E3D271D9D8C3|rigid:LZQfNkQV7Nxvdp5h32EtFkOtfgs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9R078	uniprotkb:Q5EG47	intact:EBI-2366248|uniprotkb:Q91YN6|ensembl:ENSMUSP00000031486|ensembl:ENSMUSP00000107630	intact:EBI-7282395|intact:UNK-5438461|ensembl:ENSMUSP00000063166	psi-mi:aakb1_mouse(display_long)|uniprotkb:Prkab1(gene name)|psi-mi:Prkab1(display_short)	psi-mi:aapk1_mouse(display_long)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Prkaa1(gene name)|psi-mi:Prkaa1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928328|mint:MINT-6768396|imex:IM-11626-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114075.1|refseq:XP_006530264.1|ensembl:ENSMUSG00000029513(gene)|ensembl:ENSMUST00000031486(transcript)|ensembl:ENSMUST00000111999(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9R078|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|mint:MINT-6768403(identity)	refseq:NP_001013385.3|ensembl:ENSMUSG00000050697(gene)|ensembl:ENSMUST00000051186(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q5EG47|rcsb pdb:5UFU|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|dip:DIP-47622N|mint:MINT-6768530(identity)	-	-	function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit|comment:mint|comment:homomint	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2008/09/19	2014/10/16	rogid:FutyYXgmMYBa1yaSlduxfVqV7z410090	rogid:9VI1u7JfAe+OsB+ncOxDv5ujYuE10090	intact-crc:0C8A48B931333010|rigid:LZQfNkQV7Nxvdp5h32EtFkOtfgs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9R078	uniprotkb:O54950	intact:EBI-2366248|uniprotkb:Q91YN6|ensembl:ENSMUSP00000031486|ensembl:ENSMUSP00000107630	intact:EBI-7927886|uniprotkb:Q5PRE8|intact:MINT-4583597|ensembl:ENSMUSP00000132499	psi-mi:aakb1_mouse(display_long)|uniprotkb:Prkab1(gene name)|psi-mi:Prkab1(display_short)	psi-mi:aakg1_mouse(display_long)|uniprotkb:Prkag1(gene name)|psi-mi:Prkag1(display_short)|uniprotkb:Prkaac(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928328|mint:MINT-6768396|imex:IM-11626-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114075.1|refseq:XP_006530264.1|ensembl:ENSMUSG00000029513(gene)|ensembl:ENSMUST00000031486(transcript)|ensembl:ENSMUST00000111999(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9R078|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|mint:MINT-6768403(identity)	refseq:NP_058061.2|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043531"(ADP binding)|ensembl:ENSMUSG00000067713(gene)|ensembl:ENSMUST00000168846(transcript)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|mint:O54950|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|mint:MINT-6768550(identity)	-	-	comment:mint|function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2008/09/19	2014/10/16	rogid:FutyYXgmMYBa1yaSlduxfVqV7z410090	rogid:QbsRkFjF/c8PqK9DB5D637VeMzc10090	intact-crc:0C8A48B931333010|rigid:LZQfNkQV7Nxvdp5h32EtFkOtfgs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9R078	uniprotkb:O70302	intact:EBI-2366248|uniprotkb:Q91YN6|ensembl:ENSMUSP00000031486|ensembl:ENSMUSP00000107630	intact:EBI-7927848|intact:UNK-5365136|uniprotkb:Q4V9X2|ensembl:ENSMUSP00000025404	psi-mi:aakb1_mouse(display_long)|uniprotkb:Prkab1(gene name)|psi-mi:Prkab1(display_short)	psi-mi:cidea_mouse(display_long)|uniprotkb:Cidea(gene name)|psi-mi:Cidea(display_short)|uniprotkb:Cell death-inducing DFFA-like effector A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928328|mint:MINT-6768396|imex:IM-11626-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114075.1|refseq:XP_006530264.1|ensembl:ENSMUSG00000029513(gene)|ensembl:ENSMUST00000031486(transcript)|ensembl:ENSMUST00000111999(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9R078|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|mint:MINT-6768403(identity)	refseq:NP_031728.2|go:"GO:0008219"(cell death)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0019915"(lipid storage)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0070417"(cellular response to cold)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR032936|mint:O70302|reactome:R-MMU-8964572|go:"GO:0006915"(apoptotic process)|ensembl:ENSMUSG00000024526(gene)|ensembl:ENSMUST00000025404(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005811"(lipid droplet)|go:"GO:0006629"(lipid metabolic process)|mint:MINT-6768399(identity)	-	-	comment:mint|function:Activates apoptosis	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2008/09/19	2014/10/16	rogid:FutyYXgmMYBa1yaSlduxfVqV7z410090	rogid:w5xZdqvm/6mXDm8UEg4ecuqJhUQ10090	intact-crc:0C8A48B931333010|rigid:LZQfNkQV7Nxvdp5h32EtFkOtfgs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5EG47	uniprotkb:O54950	intact:EBI-7282395|intact:UNK-5438461|ensembl:ENSMUSP00000063166	intact:EBI-7927886|uniprotkb:Q5PRE8|intact:MINT-4583597|ensembl:ENSMUSP00000132499	psi-mi:aapk1_mouse(display_long)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Prkaa1(gene name)|psi-mi:Prkaa1(display_short)	psi-mi:aakg1_mouse(display_long)|uniprotkb:Prkag1(gene name)|psi-mi:Prkag1(display_short)|uniprotkb:Prkaac(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928417|mint:MINT-6768607|imex:IM-11626-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013385.3|ensembl:ENSMUSG00000050697(gene)|ensembl:ENSMUST00000051186(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q5EG47|rcsb pdb:5UFU|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|dip:DIP-47622N|mint:MINT-6768611(identity)	refseq:NP_058061.2|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043531"(ADP binding)|ensembl:ENSMUSG00000067713(gene)|ensembl:ENSMUST00000168846(transcript)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|mint:O54950|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|mint:MINT-6768609(identity)	-	function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit|comment:mint|comment:homomint	comment:mint|function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2008/09/19	2014/10/16	rogid:9VI1u7JfAe+OsB+ncOxDv5ujYuE10090	rogid:QbsRkFjF/c8PqK9DB5D637VeMzc10090	intact-crc:0050E41FC345908B|rigid:LZQfNkQV7Nxvdp5h32EtFkOtfgs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5EG47	uniprotkb:O70302	intact:EBI-7282395|intact:UNK-5438461|ensembl:ENSMUSP00000063166	intact:EBI-7927848|intact:UNK-5365136|uniprotkb:Q4V9X2|ensembl:ENSMUSP00000025404	psi-mi:aapk1_mouse(display_long)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Prkaa1(gene name)|psi-mi:Prkaa1(display_short)	psi-mi:cidea_mouse(display_long)|uniprotkb:Cidea(gene name)|psi-mi:Cidea(display_short)|uniprotkb:Cell death-inducing DFFA-like effector A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928417|mint:MINT-6768607|imex:IM-11626-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013385.3|ensembl:ENSMUSG00000050697(gene)|ensembl:ENSMUST00000051186(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q5EG47|rcsb pdb:5UFU|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|dip:DIP-47622N|mint:MINT-6768611(identity)	refseq:NP_031728.2|go:"GO:0008219"(cell death)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0019915"(lipid storage)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0070417"(cellular response to cold)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR032936|mint:O70302|reactome:R-MMU-8964572|go:"GO:0006915"(apoptotic process)|ensembl:ENSMUSG00000024526(gene)|ensembl:ENSMUST00000025404(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005811"(lipid droplet)|go:"GO:0006629"(lipid metabolic process)|mint:MINT-6768615(identity)	-	function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit|comment:mint|comment:homomint	comment:mint|function:Activates apoptosis	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2008/09/19	2014/10/16	rogid:9VI1u7JfAe+OsB+ncOxDv5ujYuE10090	rogid:w5xZdqvm/6mXDm8UEg4ecuqJhUQ10090	intact-crc:0050E41FC345908B|rigid:LZQfNkQV7Nxvdp5h32EtFkOtfgs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5EG47	uniprotkb:Q9R078	intact:EBI-7282395|intact:UNK-5438461|ensembl:ENSMUSP00000063166	intact:EBI-2366248|uniprotkb:Q91YN6|ensembl:ENSMUSP00000031486|ensembl:ENSMUSP00000107630	psi-mi:aapk1_mouse(display_long)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Prkaa1(gene name)|psi-mi:Prkaa1(display_short)	psi-mi:aakb1_mouse(display_long)|uniprotkb:Prkab1(gene name)|psi-mi:Prkab1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928417|mint:MINT-6768607|imex:IM-11626-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013385.3|ensembl:ENSMUSG00000050697(gene)|ensembl:ENSMUST00000051186(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q5EG47|rcsb pdb:5UFU|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|dip:DIP-47622N|mint:MINT-6768611(identity)	refseq:NP_114075.1|refseq:XP_006530264.1|ensembl:ENSMUSG00000029513(gene)|ensembl:ENSMUST00000031486(transcript)|ensembl:ENSMUST00000111999(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9R078|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|mint:MINT-6768613(identity)	-	function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit|comment:mint|comment:homomint	-	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2008/09/19	2014/10/16	rogid:9VI1u7JfAe+OsB+ncOxDv5ujYuE10090	rogid:FutyYXgmMYBa1yaSlduxfVqV7z410090	intact-crc:0050E41FC345908B|rigid:LZQfNkQV7Nxvdp5h32EtFkOtfgs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70302	uniprotkb:O54950	intact:EBI-7927848|intact:UNK-5365136|uniprotkb:Q4V9X2|ensembl:ENSMUSP00000025404	intact:EBI-7927886|uniprotkb:Q5PRE8|intact:MINT-4583597|ensembl:ENSMUSP00000132499	psi-mi:cidea_mouse(display_long)|uniprotkb:Cidea(gene name)|psi-mi:Cidea(display_short)|uniprotkb:Cell death-inducing DFFA-like effector A(gene name synonym)	psi-mi:aakg1_mouse(display_long)|uniprotkb:Prkag1(gene name)|psi-mi:Prkag1(display_short)|uniprotkb:Prkaac(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928364|mint:MINT-6768594|imex:IM-11626-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031728.2|go:"GO:0008219"(cell death)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0019915"(lipid storage)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0070417"(cellular response to cold)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR032936|mint:O70302|reactome:R-MMU-8964572|go:"GO:0006915"(apoptotic process)|ensembl:ENSMUSG00000024526(gene)|ensembl:ENSMUST00000025404(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005811"(lipid droplet)|go:"GO:0006629"(lipid metabolic process)|mint:MINT-6768596(identity)	refseq:NP_058061.2|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043531"(ADP binding)|ensembl:ENSMUSG00000067713(gene)|ensembl:ENSMUST00000168846(transcript)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|mint:O54950|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|mint:MINT-6768602(identity)	-	comment:mint|function:Activates apoptosis	comment:mint|function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2008/09/19	2014/10/16	rogid:w5xZdqvm/6mXDm8UEg4ecuqJhUQ10090	rogid:QbsRkFjF/c8PqK9DB5D637VeMzc10090	intact-crc:108C41D735CF3300|rigid:LZQfNkQV7Nxvdp5h32EtFkOtfgs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70302	uniprotkb:Q5EG47	intact:EBI-7927848|intact:UNK-5365136|uniprotkb:Q4V9X2|ensembl:ENSMUSP00000025404	intact:EBI-7282395|intact:UNK-5438461|ensembl:ENSMUSP00000063166	psi-mi:cidea_mouse(display_long)|uniprotkb:Cidea(gene name)|psi-mi:Cidea(display_short)|uniprotkb:Cell death-inducing DFFA-like effector A(gene name synonym)	psi-mi:aapk1_mouse(display_long)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Prkaa1(gene name)|psi-mi:Prkaa1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928364|mint:MINT-6768594|imex:IM-11626-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031728.2|go:"GO:0008219"(cell death)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0019915"(lipid storage)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0070417"(cellular response to cold)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR032936|mint:O70302|reactome:R-MMU-8964572|go:"GO:0006915"(apoptotic process)|ensembl:ENSMUSG00000024526(gene)|ensembl:ENSMUST00000025404(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005811"(lipid droplet)|go:"GO:0006629"(lipid metabolic process)|mint:MINT-6768596(identity)	refseq:NP_001013385.3|ensembl:ENSMUSG00000050697(gene)|ensembl:ENSMUST00000051186(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q5EG47|rcsb pdb:5UFU|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|dip:DIP-47622N|mint:MINT-6768600(identity)	-	comment:mint|function:Activates apoptosis	function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit|comment:mint|comment:homomint	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2008/09/19	2014/10/16	rogid:w5xZdqvm/6mXDm8UEg4ecuqJhUQ10090	rogid:9VI1u7JfAe+OsB+ncOxDv5ujYuE10090	intact-crc:108C41D735CF3300|rigid:LZQfNkQV7Nxvdp5h32EtFkOtfgs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70302	uniprotkb:Q9R078	intact:EBI-7927848|intact:UNK-5365136|uniprotkb:Q4V9X2|ensembl:ENSMUSP00000025404	intact:EBI-2366248|uniprotkb:Q91YN6|ensembl:ENSMUSP00000031486|ensembl:ENSMUSP00000107630	psi-mi:cidea_mouse(display_long)|uniprotkb:Cidea(gene name)|psi-mi:Cidea(display_short)|uniprotkb:Cell death-inducing DFFA-like effector A(gene name synonym)	psi-mi:aakb1_mouse(display_long)|uniprotkb:Prkab1(gene name)|psi-mi:Prkab1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928364|mint:MINT-6768594|imex:IM-11626-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031728.2|go:"GO:0008219"(cell death)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0019915"(lipid storage)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0070417"(cellular response to cold)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR032936|mint:O70302|reactome:R-MMU-8964572|go:"GO:0006915"(apoptotic process)|ensembl:ENSMUSG00000024526(gene)|ensembl:ENSMUST00000025404(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005811"(lipid droplet)|go:"GO:0006629"(lipid metabolic process)|mint:MINT-6768596(identity)	refseq:NP_114075.1|refseq:XP_006530264.1|ensembl:ENSMUSG00000029513(gene)|ensembl:ENSMUST00000031486(transcript)|ensembl:ENSMUST00000111999(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9R078|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|mint:MINT-6768598(identity)	-	comment:mint|function:Activates apoptosis	-	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2008/09/19	2014/10/16	rogid:w5xZdqvm/6mXDm8UEg4ecuqJhUQ10090	rogid:FutyYXgmMYBa1yaSlduxfVqV7z410090	intact-crc:108C41D735CF3300|rigid:LZQfNkQV7Nxvdp5h32EtFkOtfgs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70302	uniprotkb:Q9Y478	intact:EBI-7927848|intact:UNK-5365136|uniprotkb:Q4V9X2|ensembl:ENSMUSP00000025404	intact:EBI-719769|uniprotkb:Q9UBV0|uniprotkb:Q9UE20|uniprotkb:Q9UEX2|uniprotkb:Q9Y6V8|ensembl:ENSP00000229328|ensembl:ENSP00000441369	psi-mi:cidea_mouse(display_long)|uniprotkb:Cidea(gene name)|psi-mi:Cidea(display_short)|uniprotkb:Cell death-inducing DFFA-like effector A(gene name synonym)	psi-mi:aakb1_human(display_long)|uniprotkb:PRKAB1(gene name)|psi-mi:PRKAB1(display_short)|uniprotkb:AMPK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928494|mint:MINT-6768809|imex:IM-11626-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031728.2|go:"GO:0008219"(cell death)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0019915"(lipid storage)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0070417"(cellular response to cold)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR032936|mint:O70302|reactome:R-MMU-8964572|go:"GO:0006915"(apoptotic process)|ensembl:ENSMUSG00000024526(gene)|ensembl:ENSMUST00000025404(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005811"(lipid droplet)|go:"GO:0006629"(lipid metabolic process)|mint:MINT-6768816(identity)	refseq:NP_006244.2|ensembl:ENSG00000111725(gene)|ensembl:ENST00000229328(transcript)|ensembl:ENST00000541640(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9Y478|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|go:"GO:0005654"(nucleoplasm)|refseq:XP_005253966.1|dip:DIP-39736N|mint:MINT-6768812(identity)	-	comment:mint|function:Activates apoptosis	-	figure legend:F3A F3B F3C F3D|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/09/19	2014/10/16	rogid:w5xZdqvm/6mXDm8UEg4ecuqJhUQ10090	rogid:QJftPEDhjfudQn6uXn5nWOkchc09606	intact-crc:E686E0AF8A1683E4|rigid:4doKhZNnDJU8lebe6q9jc2lkblo	false	binding-associated region:?-?(MINT-6770257)|ha tag:?-?(MINT-6768817)	flag tag:?-?(MINT-6768813)|binding-associated region:231-248(MINT-6770574)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y478	uniprotkb:P54619	intact:EBI-719769|uniprotkb:Q9UBV0|uniprotkb:Q9UE20|uniprotkb:Q9UEX2|uniprotkb:Q9Y6V8|ensembl:ENSP00000229328|ensembl:ENSP00000441369	intact:EBI-1181439|ensembl:ENSP00000447433|uniprotkb:B4DDT7|uniprotkb:Q8N7V9	psi-mi:aakb1_human(display_long)|uniprotkb:PRKAB1(gene name)|psi-mi:PRKAB1(display_short)|uniprotkb:AMPK(gene name synonym)	psi-mi:aakg1_human(display_long)|uniprotkb:PRKAG1(gene name)|psi-mi:PRKAG1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928540|mint:MINT-6771220|imex:IM-11626-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006244.2|ensembl:ENSG00000111725(gene)|ensembl:ENST00000229328(transcript)|ensembl:ENST00000541640(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9Y478|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|go:"GO:0005654"(nucleoplasm)|refseq:XP_005253966.1|dip:DIP-39736N|mint:MINT-6771228(identity)	refseq:NP_001193638.1|refseq:NP_001193639.1|refseq:NP_002724.1|refseq:XP_011536864.1|reactome:R-HSA-9619483|reactome:R-HSA-9613354|ensembl:ENSG00000181929(gene)|ensembl:ENST00000548065(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043531"(ADP binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|mint:P54619|rcsb pdb:2UV4|rcsb pdb:2UV5|rcsb pdb:2UV6|rcsb pdb:2UV7|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6B2E|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|refseq:XP_006719562.1|dip:DIP-39974N|mint:MINT-6771222(identity)	-	-	-	figure legend:F3D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/09/19	2014/10/16	rogid:QJftPEDhjfudQn6uXn5nWOkchc09606	rogid:JNBzPdCbcgr37RKb2sk6yVL+7649606	intact-crc:BC103523C7BA49E4|rigid:1MDyqVhi52EPfvks7jw+fYqfpBo	false	flag tag:?-?(MINT-6771231)|binding-associated region:186-270(MINT-6771229)	myc tag:?-?(MINT-6771225)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O70302	uniprotkb:P62991	intact:EBI-7927848|intact:UNK-5365136|uniprotkb:Q4V9X2|ensembl:ENSMUSP00000025404	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	psi-mi:cidea_mouse(display_long)|uniprotkb:Cidea(gene name)|psi-mi:Cidea(display_short)|uniprotkb:Cell death-inducing DFFA-like effector A(gene name synonym)	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928603|mint:MINT-6771281|imex:IM-11626-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031728.2|go:"GO:0008219"(cell death)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0019915"(lipid storage)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0070417"(cellular response to cold)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR032936|mint:O70302|reactome:R-MMU-8964572|go:"GO:0006915"(apoptotic process)|ensembl:ENSMUSG00000024526(gene)|ensembl:ENSMUST00000025404(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005811"(lipid droplet)|go:"GO:0006629"(lipid metabolic process)|mint:MINT-6771283(identity)	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K|mint:MINT-6771289(identity)	-	comment:mint|function:Activates apoptosis	-	figure legend:F4F|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/09/19	2014/10/16	rogid:w5xZdqvm/6mXDm8UEg4ecuqJhUQ10090	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	intact-crc:A27A3F0510E2AC01|rigid:nXDFIigEJ3SgRyRPnttNWNm1sbE	false	ha tag:?-?(MINT-6771286)	myc tag:?-?(MINT-6771292)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y478	uniprotkb:Q13131	intact:EBI-719769|uniprotkb:Q9UBV0|uniprotkb:Q9UE20|uniprotkb:Q9UEX2|uniprotkb:Q9Y6V8|ensembl:ENSP00000229328|ensembl:ENSP00000441369	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	psi-mi:aakb1_human(display_long)|uniprotkb:PRKAB1(gene name)|psi-mi:PRKAB1(display_short)|uniprotkb:AMPK(gene name synonym)	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928563|mint:MINT-6771238|imex:IM-11626-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006244.2|ensembl:ENSG00000111725(gene)|ensembl:ENST00000229328(transcript)|ensembl:ENST00000541640(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9Y478|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|go:"GO:0005654"(nucleoplasm)|refseq:XP_005253966.1|dip:DIP-39736N|mint:MINT-6771244(identity)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N|mint:MINT-6771240(identity)	-	-	-	figure legend:F3D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/09/19	2014/10/16	rogid:QJftPEDhjfudQn6uXn5nWOkchc09606	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	intact-crc:B08AA11CBEA9BDD8|rigid:k95z3DAdxJf0aAz12qsfV5r4BsA	false	binding-associated region:186-208(MINT-6771247)|flag tag:?-?(MINT-6771245)	myc tag:?-?(MINT-6771241)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P62991	uniprotkb:Q9Y478	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	intact:EBI-719769|uniprotkb:Q9UBV0|uniprotkb:Q9UE20|uniprotkb:Q9UEX2|uniprotkb:Q9Y6V8|ensembl:ENSP00000229328|ensembl:ENSP00000441369	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:aakb1_human(display_long)|uniprotkb:PRKAB1(gene name)|psi-mi:PRKAB1(display_short)|uniprotkb:AMPK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928684|mint:MINT-6771299|imex:IM-11626-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K|mint:MINT-6771301(identity)	refseq:NP_006244.2|ensembl:ENSG00000111725(gene)|ensembl:ENST00000229328(transcript)|ensembl:ENST00000541640(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9Y478|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|go:"GO:0005654"(nucleoplasm)|refseq:XP_005253966.1|dip:DIP-39736N|mint:MINT-6771305(identity)	-	-	-	figure legend:F4F|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/09/19	2014/10/16	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	rogid:QJftPEDhjfudQn6uXn5nWOkchc09606	intact-crc:E75CC3E0833038C8|rigid:NCRHSBQjExJ9g4w+oRfp+IWg56Y	false	myc tag:?-?(MINT-6771302)	flag tag:?-?(MINT-6771306)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O70302	uniprotkb:Q9Y478	intact:EBI-7927848|intact:UNK-5365136|uniprotkb:Q4V9X2|ensembl:ENSMUSP00000025404	intact:EBI-719769|uniprotkb:Q9UBV0|uniprotkb:Q9UE20|uniprotkb:Q9UEX2|uniprotkb:Q9Y6V8|ensembl:ENSP00000229328|ensembl:ENSP00000441369	psi-mi:cidea_mouse(display_long)|uniprotkb:Cidea(gene name)|psi-mi:Cidea(display_short)|uniprotkb:Cell death-inducing DFFA-like effector A(gene name synonym)	psi-mi:aakb1_human(display_long)|uniprotkb:PRKAB1(gene name)|psi-mi:PRKAB1(display_short)|uniprotkb:AMPK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928757|mint:MINT-6768893|imex:IM-11626-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031728.2|go:"GO:0008219"(cell death)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0019915"(lipid storage)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0070417"(cellular response to cold)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR032936|mint:O70302|reactome:R-MMU-8964572|go:"GO:0006915"(apoptotic process)|ensembl:ENSMUSG00000024526(gene)|ensembl:ENSMUST00000025404(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005811"(lipid droplet)|go:"GO:0006629"(lipid metabolic process)|mint:MINT-6768895(identity)	refseq:NP_006244.2|ensembl:ENSG00000111725(gene)|ensembl:ENST00000229328(transcript)|ensembl:ENST00000541640(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9Y478|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|go:"GO:0005654"(nucleoplasm)|refseq:XP_005253966.1|dip:DIP-39736N|mint:MINT-6768899(identity)	-	comment:mint|function:Activates apoptosis	-	figure legend:SF3|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/09/19	2014/10/16	rogid:w5xZdqvm/6mXDm8UEg4ecuqJhUQ10090	rogid:QJftPEDhjfudQn6uXn5nWOkchc09606	intact-crc:D4708DB72969C4C3|rigid:4doKhZNnDJU8lebe6q9jc2lkblo	false	-	ha tag:?-?(MINT-6768900)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O70302	uniprotkb:P56198	intact:EBI-7927848|intact:UNK-5365136|uniprotkb:Q4V9X2|ensembl:ENSMUSP00000025404	intact:EBI-7928793|uniprotkb:Q499X5|uniprotkb:Q8BNV7|intact:MINT-6768962|ensembl:ENSMUSP00000032416|ensembl:ENSMUSP00000108712	psi-mi:cidea_mouse(display_long)|uniprotkb:Cidea(gene name)|psi-mi:Cidea(display_short)|uniprotkb:Cell death-inducing DFFA-like effector A(gene name synonym)	psi-mi:cidec_mouse(display_long)|uniprotkb:Cidec(gene name)|psi-mi:Cidec(display_short)|uniprotkb:Fsp27(gene name synonym)|uniprotkb:Fat-specific protein FSP27(gene name synonym)|uniprotkb:Cell death-inducing DFFA-like effector protein C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qi et al. (2008)	pubmed:18480843|imex:IM-11626|mint:MINT-6767403	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7928819|mint:MINT-6768940|imex:IM-11626-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031728.2|go:"GO:0008219"(cell death)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0019915"(lipid storage)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0070417"(cellular response to cold)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR032936|mint:O70302|reactome:R-MMU-8964572|go:"GO:0006915"(apoptotic process)|ensembl:ENSMUSG00000024526(gene)|ensembl:ENSMUST00000025404(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005811"(lipid droplet)|go:"GO:0006629"(lipid metabolic process)|mint:MINT-6768946(identity)	refseq:NP_001288224.1|refseq:NP_848460.1|ensembl:ENSMUSG00000030278(gene)|ensembl:ENSMUST00000032416(transcript)|ensembl:ENSMUST00000113089(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|mint:P56198|rcsb pdb:4IKG|rcsb pdb:4MAC|reactome:R-MMU-8964572|mint:MINT-6768942(identity)	-	comment:mint|function:Activates apoptosis	comment:mint|function:Induces apoptosis	figure legend:SF3|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/09/19	2014/10/16	rogid:w5xZdqvm/6mXDm8UEg4ecuqJhUQ10090	rogid:HxyczSB1ttYaYwGy5SNApUNFY4o10090	intact-crc:FE1E3BAEB718985E|rigid:YStD9VwqDN4kLH0g0LUnaxJboXE	false	-	ha tag:?-?(MINT-6768943)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)