#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92900-2	uniprotkb:P38919	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	intact:EBI-299104|ensembl:ENSP00000497641|ensembl:ENSP00000497661|uniprotkb:Q15033|uniprotkb:Q96A18|uniprotkb:Q6IBQ2	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:if4a3_human(display_long)|uniprotkb:KIAA0111(gene name synonym)|uniprotkb:EIF4A3(gene name)|psi-mi:EIF4A3(display_short)|uniprotkb:DDX48(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 4A isoform 3(gene name synonym)|uniprotkb:ATP-dependent RNA helicase eIF4A-3(gene name synonym)|uniprotkb:ATP-dependent RNA helicase DDX48(gene name synonym)|uniprotkb:DEAD box protein 48(gene name synonym)|uniprotkb:Eukaryotic initiation factor 4A-like NUK-34(gene name synonym)|uniprotkb:Nuclear matrix protein 265(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1776452|imex:IM-11956-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008306"(associative learning)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051028"(mRNA transport)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072715"(cellular response to selenite ion)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904570"(negative regulation of selenocysteine incorporation)|go:"GO:1904574"(negative regulation of selenocysteine insertion sequence binding)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P38919|rcsb pdb:2HXY|rcsb pdb:2HYI|rcsb pdb:2J0Q|rcsb pdb:2J0S|rcsb pdb:2J0U|rcsb pdb:2XB2|rcsb pdb:3EX7|rcsb pdb:4C9B|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6YVH|rcsb pdb:7A5P|reactome:R-HSA-1169408|reactome:R-HSA-159236|reactome:R-HSA-429947|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9010553|reactome:R-HSA-975957|ensembl:ENST00000647795(transcript)|ensembl:ENST00000649764(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|ensembl:ENSG00000141543(gene)|refseq:NP_055555.1|dip:DIP-33218N	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available	-	comment:"SMG1 and GSPT1 preferentially bound to myc-Upf1(WT) compared to myc-Upf1(G495R/G497E). By contrast, the EJC core constituent eIF4AIII showed a very slight preference for myc-Upf1(G495R/G497E) compared to myc-Upf1R(WT) and degradative activities known to function in nonsense-mediated mRNA decay, including the decapping activator DCP1a, the 5'-to-3' exonuclease XRN1, and the exosomal component RRP4, bound preferentially to myc-Upf1R(G495R/G497E)"|comment:Treatment of the cells with okadaic acid, inhibiting phosphatase activity, resulted in the accumulation of phospho-Upf resulted in decreased binding of SMG1 and increased EIF4AIII binding.|figure legend:Fig. 1A and 1B|delivery method:Q92900-2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/21	2018/09/18	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	rogid:8e6e4HlM1GsYqqgXyJ9XgzxLzls9606	intact-crc:0049AA89F88CDEBC|rigid:+yrcOjyxGZwZY8UIMah6GG/m8Os	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92900-2	uniprotkb:Q13868	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	intact:EBI-301735|uniprotkb:Q9NUY4|uniprotkb:A3KFL3|ensembl:ENSP00000361433|uniprotkb:A3KFL4|uniprotkb:B4DKK6	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:exos2_human(display_long)|uniprotkb:EXOSC2(gene name)|psi-mi:EXOSC2(display_short)|uniprotkb:RRP4(gene name synonym)|uniprotkb:Ribosomal RNA-processing protein 4(gene name synonym)|uniprotkb:Exosome component 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1776452|imex:IM-11956-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	refseq:NP_055100.2|ensembl:ENSG00000130713(gene)|ensembl:ENST00000372358(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0008312"(7S RNA binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034475"(U4 snRNA 3'-end processing)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0071034"(CUT catabolic process)|go:"GO:0071035"(nuclear polyadenylation-dependent rRNA catabolic process)|go:"GO:0071038"(nuclear polyadenylation-dependent tRNA catabolic process)|go:"GO:0071049"|go:"GO:0071051"(polyadenylation-dependent snoRNA 3'-end processing)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR025721|interpro:IPR026699|interpro:IPR036612|mint:Q13868|rcsb pdb:2NN6|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6H25|reactome:R-HSA-380994|reactome:R-HSA-429958|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604|reactome:R-HSA-6791226|refseq:NP_001269638.1|dip:DIP-31264N|refseq:NP_001269637.1	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available	-	comment:"SMG1 and GSPT1 preferentially bound to myc-Upf1(WT) compared to myc-Upf1(G495R/G497E). By contrast, the EJC core constituent eIF4AIII showed a very slight preference for myc-Upf1(G495R/G497E) compared to myc-Upf1R(WT) and degradative activities known to function in nonsense-mediated mRNA decay, including the decapping activator DCP1a, the 5'-to-3' exonuclease XRN1, and the exosomal component RRP4, bound preferentially to myc-Upf1R(G495R/G497E)"|comment:Treatment of the cells with okadaic acid, inhibiting phosphatase activity, resulted in the accumulation of phospho-Upf resulted in decreased binding of SMG1 and increased EIF4AIII binding.|figure legend:Fig. 1A and 1B|delivery method:Q92900-2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/21	2018/09/18	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	rogid:Lpl4OBbEYV2DRbYzLCPvbQdtaro9606	intact-crc:0049AA89F88CDEBC|rigid:+yrcOjyxGZwZY8UIMah6GG/m8Os	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92900-2	uniprotkb:Q9NPI6	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1776452|imex:IM-11956-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available	-	comment:"SMG1 and GSPT1 preferentially bound to myc-Upf1(WT) compared to myc-Upf1(G495R/G497E). By contrast, the EJC core constituent eIF4AIII showed a very slight preference for myc-Upf1(G495R/G497E) compared to myc-Upf1R(WT) and degradative activities known to function in nonsense-mediated mRNA decay, including the decapping activator DCP1a, the 5'-to-3' exonuclease XRN1, and the exosomal component RRP4, bound preferentially to myc-Upf1R(G495R/G497E)"|comment:Treatment of the cells with okadaic acid, inhibiting phosphatase activity, resulted in the accumulation of phospho-Upf resulted in decreased binding of SMG1 and increased EIF4AIII binding.|figure legend:Fig. 1A and 1B|delivery method:Q92900-2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/21	2018/09/18	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606	intact-crc:0049AA89F88CDEBC|rigid:+yrcOjyxGZwZY8UIMah6GG/m8Os	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92900-2	uniprotkb:P15170	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	intact:EBI-948993|ensembl:ENSP00000399539|ensembl:ENSP00000454351|uniprotkb:Q96GF2|uniprotkb:J3KQG6	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:erf3a_human(display_long)|uniprotkb:G1 to S phase transition protein 1 homolog(gene name synonym)|uniprotkb:GSPT1(gene name)|psi-mi:GSPT1(display_short)|uniprotkb:ERF3A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1776452|imex:IM-11956-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	ensembl:ENSG00000103342(gene)|ensembl:ENST00000420576(transcript)|ensembl:ENST00000563468(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003723"(RNA binding)|go:"GO:0003747"(translation release factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0006479"(protein methylation)|go:"GO:0018444"(translation release factor complex)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|mint:P15170|rcsb pdb:3E1Y|rcsb pdb:3J5Y|rcsb pdb:3KUI|rcsb pdb:4D61|rcsb pdb:5HXB|rcsb pdb:5LZT|rcsb pdb:6XK9|interpro:IPR031157|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001123479.1|refseq:NP_001123478.1	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available	-	comment:"SMG1 and GSPT1 preferentially bound to myc-Upf1(WT) compared to myc-Upf1(G495R/G497E). By contrast, the EJC core constituent eIF4AIII showed a very slight preference for myc-Upf1(G495R/G497E) compared to myc-Upf1R(WT) and degradative activities known to function in nonsense-mediated mRNA decay, including the decapping activator DCP1a, the 5'-to-3' exonuclease XRN1, and the exosomal component RRP4, bound preferentially to myc-Upf1R(G495R/G497E)"|comment:Treatment of the cells with okadaic acid, inhibiting phosphatase activity, resulted in the accumulation of phospho-Upf resulted in decreased binding of SMG1 and increased EIF4AIII binding.|figure legend:Fig. 1A and 1B|delivery method:Q92900-2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/21	2018/09/18	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	rogid:ckNeqdEYS+CaYKzZWTBzKGJlmsI9606	intact-crc:0049AA89F88CDEBC|rigid:+yrcOjyxGZwZY8UIMah6GG/m8Os	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92900-2	uniprotkb:Q8IZH2	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	intact:EBI-372406|uniprotkb:Q4G0S3|uniprotkb:Q68D88|uniprotkb:Q6AI24|uniprotkb:Q6MZS8|uniprotkb:Q86WS7|uniprotkb:Q8N8U4|uniprotkb:Q9UF39|ensembl:ENSP00000264951	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:xrn1_human(display_long)|uniprotkb:Strand-exchange protein 1 homolog(gene name synonym)|uniprotkb:XRN1(gene name)|psi-mi:XRN1(display_short)|uniprotkb:SEP1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1776452|imex:IM-11956-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	refseq:NP_061874.3|refseq:NP_001269786.1|refseq:NP_001269788.1|ensembl:ENSG00000114127(gene)|ensembl:ENST00000264951(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0033574"(response to testosterone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071409"(cellular response to cycloheximide)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1905795"(cellular response to puromycin)|interpro:IPR004859(Putative 5-3 exonuclease)|interpro:IPR016494(5'-3' exoribonuclease 1)|interpro:IPR027073|interpro:IPR040992|interpro:IPR041106|interpro:IPR041385|interpro:IPR041412|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|dip:DIP-31174N	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available	-	comment:"SMG1 and GSPT1 preferentially bound to myc-Upf1(WT) compared to myc-Upf1(G495R/G497E). By contrast, the EJC core constituent eIF4AIII showed a very slight preference for myc-Upf1(G495R/G497E) compared to myc-Upf1R(WT) and degradative activities known to function in nonsense-mediated mRNA decay, including the decapping activator DCP1a, the 5'-to-3' exonuclease XRN1, and the exosomal component RRP4, bound preferentially to myc-Upf1R(G495R/G497E)"|comment:Treatment of the cells with okadaic acid, inhibiting phosphatase activity, resulted in the accumulation of phospho-Upf resulted in decreased binding of SMG1 and increased EIF4AIII binding.|figure legend:Fig. 1A and 1B|delivery method:Q92900-2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/21	2018/09/18	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	rogid:Y5wskamFEhJ+vmrGjlw4nYHiWLg9606	intact-crc:0049AA89F88CDEBC|rigid:+yrcOjyxGZwZY8UIMah6GG/m8Os	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92900-2	uniprotkb:Q96Q15	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	intact:EBI-1049832|uniprotkb:O43305|uniprotkb:Q13284|uniprotkb:Q8NFX2|uniprotkb:Q96QV0|uniprotkb:Q96RW3|ensembl:ENSP00000402515	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:smg1_human(display_long)|uniprotkb:Lambda/iota protein kinase C-interacting protein(gene name synonym)|uniprotkb:61E3.4(gene name synonym)|uniprotkb:SMG1(gene name)|psi-mi:SMG1(display_short)|uniprotkb:ATX(gene name synonym)|uniprotkb:KIAA0421(gene name synonym)|uniprotkb:LIP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1776452|imex:IM-11956-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	refseq:NP_055907.3|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR031559|interpro:IPR035175|interpro:IPR036940|interpro:IPR039414|mint:Q96Q15|rcsb pdb:6L53|rcsb pdb:6L54|rcsb pdb:6SYT|rcsb pdb:6Z3R|reactome:R-HSA-975957|ensembl:ENSG00000157106(gene)|ensembl:ENST00000446231(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032204"(regulation of telomere maintenance)	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available	-	comment:"SMG1 and GSPT1 preferentially bound to myc-Upf1(WT) compared to myc-Upf1(G495R/G497E). By contrast, the EJC core constituent eIF4AIII showed a very slight preference for myc-Upf1(G495R/G497E) compared to myc-Upf1R(WT) and degradative activities known to function in nonsense-mediated mRNA decay, including the decapping activator DCP1a, the 5'-to-3' exonuclease XRN1, and the exosomal component RRP4, bound preferentially to myc-Upf1R(G495R/G497E)"|comment:Treatment of the cells with okadaic acid, inhibiting phosphatase activity, resulted in the accumulation of phospho-Upf resulted in decreased binding of SMG1 and increased EIF4AIII binding.|figure legend:Fig. 1A and 1B|delivery method:Q92900-2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/21	2018/09/18	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	rogid:u7doCYezlcCUKq//xhk0TZ2TD009606	intact-crc:0049AA89F88CDEBC|rigid:+yrcOjyxGZwZY8UIMah6GG/m8Os	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92900-2	uniprotkb:O00303	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	intact:EBI-711990|ensembl:ENSP00000431800|ensembl:ENSP00000499218|uniprotkb:Q6IB45|uniprotkb:Q8N978|uniprotkb:A8K0S2	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:eif3f_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Deubiquitinating enzyme eIF3f(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1776488|imex:IM-11956-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	ensembl:ENSG00000175390(gene)|ensembl:ENST00000533626(transcript)|ensembl:ENST00000651655(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR027531|interpro:IPR037518|mint:O00303|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_003745.1|dip:DIP-35580N	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available	-	figure legend:Fig. 5A|comment:"myc-Upf1(G495R/G497E) immunoprecipitated the eIF3a subunit 3.5-fold more efficiently than myc-Upf1R(WT), and also interacted more efficiently with eIF3f. Increased phosphorylation of Upf1 also increased the interaction."|delivery method:Q92900-2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/21	2014/10/16	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	rogid:dpH1pTcPshcrSjNCdPPnkYiW0YU9606	intact-crc:A62312A57039702E|rigid:oRCk+BZnbQ3NdGasPWScI+2c4z4	false	myc tag:?-?|mutation increasing interaction:497-497,495-495	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92900-2	uniprotkb:Q14152	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1776488|imex:IM-11956-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available	-	figure legend:Fig. 5A|comment:"myc-Upf1(G495R/G497E) immunoprecipitated the eIF3a subunit 3.5-fold more efficiently than myc-Upf1R(WT), and also interacted more efficiently with eIF3f. Increased phosphorylation of Upf1 also increased the interaction."|delivery method:Q92900-2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/21	2014/10/16	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606	intact-crc:A62312A57039702E|rigid:oRCk+BZnbQ3NdGasPWScI+2c4z4	false	myc tag:?-?|mutation increasing interaction:497-497,495-495	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92900-2	uniprotkb:Q9BY44-2	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	intact:EBI-1776640	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:q9by44-2(display_long)|uniprotkb:EIF2A(gene name)|psi-mi:EIF2A(display_short)|uniprotkb:65 kDa eukaryotic translation initiation factor 2A(gene name synonym)|uniprotkb:CDA02(orf name)|uniprotkb:MSTP004(orf name)|uniprotkb:MSTP089(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1776650|imex:IM-11956-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	intact:EBI-1776615(isoform-parent)	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available	isoform-comment:No experimental confirmation available.	figure legend:Supp. Fig. 5D|delivery method:Q92900-2; Q9BY44-2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/21	2014/10/16	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	rogid:yjXASYvwuvqDcdzUBK+JQy/WexE9606	intact-crc:B7B548F50F36539D|rigid:XgZRjm4PrS268AhVSf87gAO/H00	false	flag tag:?-?	ha tag:51-51	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92900-2	uniprotkb:P55884	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	intact:EBI-366696|uniprotkb:Q2NL77|uniprotkb:Q9UMF9|uniprotkb:A4D208|ensembl:ENSP00000354125|ensembl:ENSP00000380206	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:eif3b_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)|uniprotkb:eIF3 p116(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)|uniprotkb:Prt1 homolog(gene name synonym)|uniprotkb:EIF3B(gene name)|psi-mi:EIF3B(display_short)|uniprotkb:EIF3S9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1776650|imex:IM-11956-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	refseq:NP_001032360.1|refseq:NP_003742.2|refseq:XP_011513901.1|refseq:XP_011513902.1|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|ensembl:ENSG00000106263(gene)|ensembl:ENST00000360876(transcript)|ensembl:ENST00000397011(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|mint:P55884|rcsb pdb:2KRB|rcsb pdb:2NLW|rcsb pdb:5K1H|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:XP_016868241.1|dip:DIP-31113N	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available	-	figure legend:Supp. Fig. 5D|delivery method:Q92900-2; Q9BY44-2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/21	2014/10/16	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	rogid:MxQFPvmuOcO/S+4NqzToozWr8K89606	intact-crc:B7B548F50F36539D|rigid:XgZRjm4PrS268AhVSf87gAO/H00	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92900-2	uniprotkb:P20042	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	intact:EBI-711977|ensembl:ENSP00000364119|uniprotkb:Q9BVU0|uniprotkb:Q9UJE4	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:if2b_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 2 subunit beta(gene name synonym)|uniprotkb:EIF2S2(gene name)|psi-mi:EIF2S2(display_short)|uniprotkb:EIF2B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1780552|imex:IM-11956-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	ensembl:ENSG00000125977(gene)|ensembl:ENST00000374980(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002176"(male germ cell proliferation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008584"(male gonad development)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|mint:P20042|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6YBV|rcsb pdb:6ZMW|rcsb pdb:6ZP4|rcsb pdb:7A09|rcsb pdb:7D43|reactome:R-HSA-156827|reactome:R-HSA-381042|reactome:R-HSA-382556|reactome:R-HSA-72649|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72731|reactome:R-HSA-9633012|reactome:R-HSA-9648895|refseq:NP_003899.2	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available	-	figure legend:Supp. Fig. 5A|delivery method:Q92900-2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/21	2014/10/16	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	rogid:64ZkCKZ5jRT6MEm9RK4AynY2ga49606	intact-crc:44D261D11782E097|rigid:U9VJ/t2HanSKJzhnw4ExuW9dnbw	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92900-2	uniprotkb:Q14152	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1780552|imex:IM-11956-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available	-	figure legend:Supp. Fig. 5A|delivery method:Q92900-2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/21	2014/10/16	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606	intact-crc:44D261D11782E097|rigid:U9VJ/t2HanSKJzhnw4ExuW9dnbw	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92900-2	uniprotkb:P55884	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	intact:EBI-366696|uniprotkb:Q2NL77|uniprotkb:Q9UMF9|uniprotkb:A4D208|ensembl:ENSP00000354125|ensembl:ENSP00000380206	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:eif3b_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)|uniprotkb:eIF3 p116(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)|uniprotkb:Prt1 homolog(gene name synonym)|uniprotkb:EIF3B(gene name)|psi-mi:EIF3B(display_short)|uniprotkb:EIF3S9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1780552|imex:IM-11956-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	refseq:NP_001032360.1|refseq:NP_003742.2|refseq:XP_011513901.1|refseq:XP_011513902.1|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|ensembl:ENSG00000106263(gene)|ensembl:ENST00000360876(transcript)|ensembl:ENST00000397011(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|mint:P55884|rcsb pdb:2KRB|rcsb pdb:2NLW|rcsb pdb:5K1H|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:XP_016868241.1|dip:DIP-31113N	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available	-	figure legend:Supp. Fig. 5A|delivery method:Q92900-2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/21	2014/10/16	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	rogid:MxQFPvmuOcO/S+4NqzToozWr8K89606	intact-crc:44D261D11782E097|rigid:U9VJ/t2HanSKJzhnw4ExuW9dnbw	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92900-2	uniprotkb:Q9BY44	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	intact:EBI-1776615|uniprotkb:Q5QTR2|uniprotkb:Q7Z4E9|uniprotkb:Q8NFM1|uniprotkb:Q96EW9|uniprotkb:Q96K81|uniprotkb:A8MPS6|uniprotkb:B4DF96|uniprotkb:B4DQ14|uniprotkb:D3DNI9|ensembl:ENSP00000417229	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:eif2a_human(display_long)|uniprotkb:EIF2A(gene name)|psi-mi:EIF2A(display_short)|uniprotkb:CDA02(orf name)|uniprotkb:MSTP004(orf name)|uniprotkb:MSTP089(orf name)|uniprotkb:65 kDa eukaryotic translation initiation factor 2A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1780552|imex:IM-11956-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	refseq:NP_114414.2|refseq:NP_001305972.1|refseq:NP_001305973.1|refseq:NP_001305974.1|refseq:NP_001305975.1|dip:DIP-40272N|ensembl:ENSG00000144895(gene)|ensembl:ENST00000460851(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0042255"(ribosome assembly)|go:"GO:0043022"(ribosome binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0072562"(blood microparticle)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR011387(Translation initiation factor eIF-2A)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q9BY44	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available	-	figure legend:Supp. Fig. 5A|delivery method:Q92900-2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/21	2014/10/16	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	rogid:67hYEz0CrhoQ7SfXxZdOWqKzil89606	intact-crc:44D261D11782E097|rigid:U9VJ/t2HanSKJzhnw4ExuW9dnbw	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14152	uniprotkb:Q92900-2	intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym)	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1789996|imex:IM-11956-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	psi-mi:"MI:0469"(intact)	-	isoform-comment:No experimental confirmation available	figure legend:Fig. 5B|agonist:Okadaic acid, a phosphatase inhibitor|delivery method:Q92900-2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/21	2014/10/16	rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	intact-crc:8DD5E2C5A124E49F|rigid:nVFESWkJCkT1d6SvHj3o5rhjWlI	false	-	myc tag:?-?|mutation increasing interaction:497-497,495-495	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92900-2	uniprotkb:Q14152	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1776509|imex:IM-11956-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available	-	figure legend:Fig. 5C, 5D|comment:"eIF3a immunoprecipitated myc-Upf1(G495R/G497E) more efficiently than myc-Upf1R(WT). Increased phosphorylation of Upf1 also increased the interaction."|delivery method:Q92900-2 transfection|comment:Levels of native Q92900-2 reduced by siRNA treatment.|agonist:Okadaic acid, a phosphatase inhibitor|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/21	2014/10/16	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606	intact-crc:C58E3D9C79AB3633|rigid:nVFESWkJCkT1d6SvHj3o5rhjWlI	false	myc tag:?-?|mutation increasing interaction:497-497,495-495	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14152	uniprotkb:Q92900-2	intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335	intact:EBI-373492|intact:EBI-7196940|intact:MINT-4931121|ensembl:ENSP00000262803	psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym)	psi-mi:q92900-2(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:RENT1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Isken et al. (2008)	imex:IM-11956|pubmed:18423202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1776599|imex:IM-11956-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N	intact:EBI-373471(rent1_human)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000262803(transcript)|uniprotkb:Q92900-2(isoform-parent)	psi-mi:"MI:0469"(intact)	-	isoform-comment:No experimental confirmation available	figure legend:Fig. 5F, 5G, 5H, Supp. Fig 5C|comment:"FLAG-Upf1(G495R/G497E) had a 3-fold stronger affinity for eIF3a than FLAG-Upf1(WT), the affinity also increased with levels of Upf1 phosphorylation"|comment:Levels of native Q92900-2 reduced by siRNA treatment.|agonist:Okadaic acid, a phosphatase inhibitor|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/21	2014/10/16	rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606	rogid:AEVnI6GRsFLhLLd1uqqsCGrDm0I9606	intact-crc:F8900B7A701C1979|rigid:nVFESWkJCkT1d6SvHj3o5rhjWlI	false	-	flag tag:?-?|mutation increasing interaction:497-497,495-495	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)