#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01580	uniprotkb:P52293	intact:EBI-7892102|intact:UNK-5368977|uniprotkb:Q542B8|ensembl:ENSMUSP00000063800	intact:EBI-3043908|ensembl:ENSMUSP00000018506|ensembl:ENSMUSP00000137310|uniprotkb:Q64292	psi-mi:ifng_mouse(display_long)|uniprotkb:Ifng(gene name)|psi-mi:Ifng(display_short)	psi-mi:ima1_mouse(display_long)|uniprotkb:Kpna2(gene name)|psi-mi:Kpna2(display_short)|uniprotkb:Rch1(gene name synonym)|uniprotkb:Importin alpha P1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-2(gene name synonym)|uniprotkb:Pendulin(gene name synonym)|uniprotkb:Pore targeting complex 58 kDa subunit(gene name synonym)|uniprotkb:RAG cohort protein 1(gene name synonym)|uniprotkb:SRP1-alpha(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fulcher et al. (2008)	pubmed:18405666|imex:IM-11614|mint:MINT-6664420|doi:10.1016/j.febslet.2008.03.054	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7892093|mint:MINT-6478490|imex:IM-11614-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032363.1|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050954"(sensory perception of mechanical stimulus)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032834"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0040008"(regulation of growth)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0032747"(positive regulation of interleukin-23 production)|ensembl:ENSMUSG00000055170(gene)|ensembl:ENSMUST00000068592(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001781"(neutrophil apoptotic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002302"(CD8-positive, alpha-beta T cell differentiation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060550"(positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0060552"(positive regulation of fructose 1,6-bisphosphate metabolic process)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071351"(cellular response to interleukin-18)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072125"(negative regulation of glomerular mesangial cell proliferation)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1904440"(positive regulation of iron ion import across plasma membrane)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR002069(Interferon gamma)|interpro:IPR009079(Four-helical cytokine-like, core)|mint:P01580|reactome:R-MMU-877300|reactome:R-MMU-877312|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|mint:MINT-6478492(identity)	ensembl:ENSMUSG00000018362(gene)|ensembl:ENSMUSG00000066878(gene)|ensembl:ENSMUST00000018506(transcript)|ensembl:ENSMUST00000086423(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043657"(host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52293|rcsb pdb:1EJL|rcsb pdb:1EJY|rcsb pdb:1IAL|rcsb pdb:1IQ1|rcsb pdb:1PJM|rcsb pdb:1PJN|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1Y2A|rcsb pdb:2C1M|rcsb pdb:2YNR|rcsb pdb:3BTR|rcsb pdb:3KND|rcsb pdb:3L3Q|rcsb pdb:3OQS|rcsb pdb:3Q5U|rcsb pdb:3RZ9|rcsb pdb:3RZX|rcsb pdb:3TPM|rcsb pdb:3TPO|rcsb pdb:3UKW|rcsb pdb:3UKX|rcsb pdb:3UKZ|rcsb pdb:3UL0|rcsb pdb:3UL1|rcsb pdb:3UVU|rcsb pdb:3VE6|rcsb pdb:3ZIN|rcsb pdb:3ZIO|rcsb pdb:3ZIP|rcsb pdb:3ZIQ|rcsb pdb:3ZIR|rcsb pdb:4BA3|rcsb pdb:4HTV|rcsb pdb:4MZ5|rcsb pdb:4MZ6|rcsb pdb:4OIH|rcsb pdb:4U54|rcsb pdb:4U58|rcsb pdb:4U5L|rcsb pdb:4U5N|rcsb pdb:4U5O|rcsb pdb:4U5S|rcsb pdb:4U5U|rcsb pdb:4U5V|rcsb pdb:4UAF|rcsb pdb:4YI0|rcsb pdb:4ZDU|rcsb pdb:5B56|rcsb pdb:5CTT|rcsb pdb:5D5K|rcsb pdb:5E6Q|rcsb pdb:5EKF|rcsb pdb:5EKG|rcsb pdb:5FC8|rcsb pdb:5GXW|rcsb pdb:3UKY|rcsb pdb:5HHG|rcsb pdb:5HUW|rcsb pdb:5HUY|rcsb pdb:5K9S|rcsb pdb:5KLR|rcsb pdb:5SVZ|rcsb pdb:5U5P|rcsb pdb:5U5R|rcsb pdb:5UMZ|rcsb pdb:5V5O|rcsb pdb:5V5P|rcsb pdb:5W41|rcsb pdb:5W4E|rcsb pdb:5W4F|rcsb pdb:5W4G|rcsb pdb:5WUM|rcsb pdb:5WUN|rcsb pdb:5X8N|rcsb pdb:6BVT|rcsb pdb:6BW0|rcsb pdb:6BW1|rcsb pdb:6D7M|rcsb pdb:6D7N|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:5KLT|rcsb pdb:6IW8|rcsb pdb:6IWA|rcsb pdb:6K06|rcsb pdb:6MJL|rcsb pdb:6P6A|rcsb pdb:6P6E|rcsb pdb:6WX7|rcsb pdb:7JJM|rcsb pdb:7JK7|rcsb pdb:7JVO|rcsb pdb:7L04|reactome:R-MMU-5693548|refseq:NP_034785.1|dip:DIP-47774N|mint:MINT-6478493(identity)	-	function:Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons|comment:mint	-	kinetics:kd 173 nanomolar|figure legend:F1 T2|comment:"The authors used the mature form (missing the first 22 amino acids) of Interferon gamma."|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/18	2014/10/16	rogid:DPL8gAtn3jVDOOBAU68pY4y0G7010090	rogid:qML5OVHqAJODiP+FSG9fTsiV3JQ10090	intact-crc:50D37C8B3095A867|rigid:RATqA0xdh/v3rCjaR0K5yszrxbw	false	binding-associated region:23-155(MINT-6478908)	glutathione s tranferase tag:?-?(MINT-6478497)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01580	uniprotkb:P52293	intact:EBI-7892102|intact:UNK-5368977|uniprotkb:Q542B8|ensembl:ENSMUSP00000063800	intact:EBI-3043908|ensembl:ENSMUSP00000018506|ensembl:ENSMUSP00000137310|uniprotkb:Q64292	psi-mi:ifng_mouse(display_long)|uniprotkb:Ifng(gene name)|psi-mi:Ifng(display_short)	psi-mi:ima1_mouse(display_long)|uniprotkb:Kpna2(gene name)|psi-mi:Kpna2(display_short)|uniprotkb:Rch1(gene name synonym)|uniprotkb:Importin alpha P1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-2(gene name synonym)|uniprotkb:Pendulin(gene name synonym)|uniprotkb:Pore targeting complex 58 kDa subunit(gene name synonym)|uniprotkb:RAG cohort protein 1(gene name synonym)|uniprotkb:SRP1-alpha(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fulcher et al. (2008)	pubmed:18405666|imex:IM-11614|mint:MINT-6664420|doi:10.1016/j.febslet.2008.03.054	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7892256|mint:MINT-6478503|imex:IM-11614-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032363.1|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050954"(sensory perception of mechanical stimulus)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032834"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0040008"(regulation of growth)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0032747"(positive regulation of interleukin-23 production)|ensembl:ENSMUSG00000055170(gene)|ensembl:ENSMUST00000068592(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001781"(neutrophil apoptotic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002302"(CD8-positive, alpha-beta T cell differentiation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060550"(positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0060552"(positive regulation of fructose 1,6-bisphosphate metabolic process)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071351"(cellular response to interleukin-18)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072125"(negative regulation of glomerular mesangial cell proliferation)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1904440"(positive regulation of iron ion import across plasma membrane)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR002069(Interferon gamma)|interpro:IPR009079(Four-helical cytokine-like, core)|mint:P01580|reactome:R-MMU-877300|reactome:R-MMU-877312|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|mint:MINT-6478505(identity)	ensembl:ENSMUSG00000018362(gene)|ensembl:ENSMUSG00000066878(gene)|ensembl:ENSMUST00000018506(transcript)|ensembl:ENSMUST00000086423(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043657"(host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52293|rcsb pdb:1EJL|rcsb pdb:1EJY|rcsb pdb:1IAL|rcsb pdb:1IQ1|rcsb pdb:1PJM|rcsb pdb:1PJN|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1Y2A|rcsb pdb:2C1M|rcsb pdb:2YNR|rcsb pdb:3BTR|rcsb pdb:3KND|rcsb pdb:3L3Q|rcsb pdb:3OQS|rcsb pdb:3Q5U|rcsb pdb:3RZ9|rcsb pdb:3RZX|rcsb pdb:3TPM|rcsb pdb:3TPO|rcsb pdb:3UKW|rcsb pdb:3UKX|rcsb pdb:3UKZ|rcsb pdb:3UL0|rcsb pdb:3UL1|rcsb pdb:3UVU|rcsb pdb:3VE6|rcsb pdb:3ZIN|rcsb pdb:3ZIO|rcsb pdb:3ZIP|rcsb pdb:3ZIQ|rcsb pdb:3ZIR|rcsb pdb:4BA3|rcsb pdb:4HTV|rcsb pdb:4MZ5|rcsb pdb:4MZ6|rcsb pdb:4OIH|rcsb pdb:4U54|rcsb pdb:4U58|rcsb pdb:4U5L|rcsb pdb:4U5N|rcsb pdb:4U5O|rcsb pdb:4U5S|rcsb pdb:4U5U|rcsb pdb:4U5V|rcsb pdb:4UAF|rcsb pdb:4YI0|rcsb pdb:4ZDU|rcsb pdb:5B56|rcsb pdb:5CTT|rcsb pdb:5D5K|rcsb pdb:5E6Q|rcsb pdb:5EKF|rcsb pdb:5EKG|rcsb pdb:5FC8|rcsb pdb:5GXW|rcsb pdb:3UKY|rcsb pdb:5HHG|rcsb pdb:5HUW|rcsb pdb:5HUY|rcsb pdb:5K9S|rcsb pdb:5KLR|rcsb pdb:5SVZ|rcsb pdb:5U5P|rcsb pdb:5U5R|rcsb pdb:5UMZ|rcsb pdb:5V5O|rcsb pdb:5V5P|rcsb pdb:5W41|rcsb pdb:5W4E|rcsb pdb:5W4F|rcsb pdb:5W4G|rcsb pdb:5WUM|rcsb pdb:5WUN|rcsb pdb:5X8N|rcsb pdb:6BVT|rcsb pdb:6BW0|rcsb pdb:6BW1|rcsb pdb:6D7M|rcsb pdb:6D7N|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:5KLT|rcsb pdb:6IW8|rcsb pdb:6IWA|rcsb pdb:6K06|rcsb pdb:6MJL|rcsb pdb:6P6A|rcsb pdb:6P6E|rcsb pdb:6WX7|rcsb pdb:7JJM|rcsb pdb:7JK7|rcsb pdb:7JVO|rcsb pdb:7L04|reactome:R-MMU-5693548|refseq:NP_034785.1|dip:DIP-47774N|mint:MINT-6478507(identity)	-	function:Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons|comment:mint	-	kinetics:kd 1.8 nanomolar|figure legend:F1 T2|comment:"The authors used the mature form (missing the first 22 amino acids) of Interferon gamma."|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/18	2014/10/16	rogid:DPL8gAtn3jVDOOBAU68pY4y0G7010090	rogid:qML5OVHqAJODiP+FSG9fTsiV3JQ10090	intact-crc:A0492F233A15DCE0|rigid:RATqA0xdh/v3rCjaR0K5yszrxbw	false	binding-associated region:117-154(MINT-6478513)	glutathione s tranferase tag:?-?(MINT-6478508)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01580	uniprotkb:P70168	intact:EBI-7892102|intact:UNK-5368977|uniprotkb:Q542B8|ensembl:ENSMUSP00000063800	intact:EBI-540580|uniprotkb:Q62117|uniprotkb:Q6GTI5|ensembl:ENSMUSP00000001479	psi-mi:ifng_mouse(display_long)|uniprotkb:Ifng(gene name)|psi-mi:Ifng(display_short)	psi-mi:imb1_mouse(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)|uniprotkb:SCG(gene name synonym)|uniprotkb:Kpnb1(gene name)|psi-mi:Kpnb1(display_short)|uniprotkb:Impnb(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fulcher et al. (2008)	pubmed:18405666|imex:IM-11614|mint:MINT-6664420|doi:10.1016/j.febslet.2008.03.054	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7892295|mint:MINT-6478516|imex:IM-11614-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032363.1|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050954"(sensory perception of mechanical stimulus)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032834"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0040008"(regulation of growth)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0032747"(positive regulation of interleukin-23 production)|ensembl:ENSMUSG00000055170(gene)|ensembl:ENSMUST00000068592(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001781"(neutrophil apoptotic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002302"(CD8-positive, alpha-beta T cell differentiation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060550"(positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0060552"(positive regulation of fructose 1,6-bisphosphate metabolic process)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071351"(cellular response to interleukin-18)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072125"(negative regulation of glomerular mesangial cell proliferation)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1904440"(positive regulation of iron ion import across plasma membrane)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR002069(Interferon gamma)|interpro:IPR009079(Four-helical cytokine-like, core)|mint:P01580|reactome:R-MMU-877300|reactome:R-MMU-877312|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|mint:MINT-6478522(identity)	refseq:NP_032405.3|ensembl:ENSMUSG00000001440(gene)|ensembl:ENSMUST00000001479(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|reactome:R-MMU-2995383|reactome:R-MMU-6798695|reactome:R-MMU-909733|reactome:R-MMU-1655829|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:P70168|rcsb pdb:1GCJ|rcsb pdb:1UKL|go:"GO:0019894"(kinesin binding)|reactome:R-MMU-140342|dip:DIP-33404N|mint:MINT-6478540(identity)	-	function:Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons|comment:mint	-	figure legend:F1 T2|kinetics:kd 73 nanomolar|comment:"Importin beta 1 interacts  with interferon gamma only in presence of Importin alpha2 (preheterodimerization). The authors used the mature form (missing the first 22 amino acids) of Interferon gamma."|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/18	2014/10/16	rogid:DPL8gAtn3jVDOOBAU68pY4y0G7010090	rogid:rYDCcZYUZp8TbcpyJE7pfz5+bvo10090	intact-crc:49AC7D6EF4049918|rigid:wwSN9XOCBB74z26/wHXmzi/ePKA	false	binding-associated region:23-155(MINT-6478915)	glutathione s tranferase tag:?-?(MINT-6489695)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01580	uniprotkb:P52293	intact:EBI-7892102|intact:UNK-5368977|uniprotkb:Q542B8|ensembl:ENSMUSP00000063800	intact:EBI-3043908|ensembl:ENSMUSP00000018506|ensembl:ENSMUSP00000137310|uniprotkb:Q64292	psi-mi:ifng_mouse(display_long)|uniprotkb:Ifng(gene name)|psi-mi:Ifng(display_short)	psi-mi:ima1_mouse(display_long)|uniprotkb:Kpna2(gene name)|psi-mi:Kpna2(display_short)|uniprotkb:Rch1(gene name synonym)|uniprotkb:Importin alpha P1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-2(gene name synonym)|uniprotkb:Pendulin(gene name synonym)|uniprotkb:Pore targeting complex 58 kDa subunit(gene name synonym)|uniprotkb:RAG cohort protein 1(gene name synonym)|uniprotkb:SRP1-alpha(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fulcher et al. (2008)	pubmed:18405666|imex:IM-11614|mint:MINT-6664420|doi:10.1016/j.febslet.2008.03.054	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7892295|mint:MINT-6478516|imex:IM-11614-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032363.1|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050954"(sensory perception of mechanical stimulus)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032834"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0040008"(regulation of growth)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0032747"(positive regulation of interleukin-23 production)|ensembl:ENSMUSG00000055170(gene)|ensembl:ENSMUST00000068592(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001781"(neutrophil apoptotic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002302"(CD8-positive, alpha-beta T cell differentiation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060550"(positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0060552"(positive regulation of fructose 1,6-bisphosphate metabolic process)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071351"(cellular response to interleukin-18)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072125"(negative regulation of glomerular mesangial cell proliferation)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1904440"(positive regulation of iron ion import across plasma membrane)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR002069(Interferon gamma)|interpro:IPR009079(Four-helical cytokine-like, core)|mint:P01580|reactome:R-MMU-877300|reactome:R-MMU-877312|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|mint:MINT-6478522(identity)	ensembl:ENSMUSG00000018362(gene)|ensembl:ENSMUSG00000066878(gene)|ensembl:ENSMUST00000018506(transcript)|ensembl:ENSMUST00000086423(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043657"(host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52293|rcsb pdb:1EJL|rcsb pdb:1EJY|rcsb pdb:1IAL|rcsb pdb:1IQ1|rcsb pdb:1PJM|rcsb pdb:1PJN|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1Y2A|rcsb pdb:2C1M|rcsb pdb:2YNR|rcsb pdb:3BTR|rcsb pdb:3KND|rcsb pdb:3L3Q|rcsb pdb:3OQS|rcsb pdb:3Q5U|rcsb pdb:3RZ9|rcsb pdb:3RZX|rcsb pdb:3TPM|rcsb pdb:3TPO|rcsb pdb:3UKW|rcsb pdb:3UKX|rcsb pdb:3UKZ|rcsb pdb:3UL0|rcsb pdb:3UL1|rcsb pdb:3UVU|rcsb pdb:3VE6|rcsb pdb:3ZIN|rcsb pdb:3ZIO|rcsb pdb:3ZIP|rcsb pdb:3ZIQ|rcsb pdb:3ZIR|rcsb pdb:4BA3|rcsb pdb:4HTV|rcsb pdb:4MZ5|rcsb pdb:4MZ6|rcsb pdb:4OIH|rcsb pdb:4U54|rcsb pdb:4U58|rcsb pdb:4U5L|rcsb pdb:4U5N|rcsb pdb:4U5O|rcsb pdb:4U5S|rcsb pdb:4U5U|rcsb pdb:4U5V|rcsb pdb:4UAF|rcsb pdb:4YI0|rcsb pdb:4ZDU|rcsb pdb:5B56|rcsb pdb:5CTT|rcsb pdb:5D5K|rcsb pdb:5E6Q|rcsb pdb:5EKF|rcsb pdb:5EKG|rcsb pdb:5FC8|rcsb pdb:5GXW|rcsb pdb:3UKY|rcsb pdb:5HHG|rcsb pdb:5HUW|rcsb pdb:5HUY|rcsb pdb:5K9S|rcsb pdb:5KLR|rcsb pdb:5SVZ|rcsb pdb:5U5P|rcsb pdb:5U5R|rcsb pdb:5UMZ|rcsb pdb:5V5O|rcsb pdb:5V5P|rcsb pdb:5W41|rcsb pdb:5W4E|rcsb pdb:5W4F|rcsb pdb:5W4G|rcsb pdb:5WUM|rcsb pdb:5WUN|rcsb pdb:5X8N|rcsb pdb:6BVT|rcsb pdb:6BW0|rcsb pdb:6BW1|rcsb pdb:6D7M|rcsb pdb:6D7N|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:5KLT|rcsb pdb:6IW8|rcsb pdb:6IWA|rcsb pdb:6K06|rcsb pdb:6MJL|rcsb pdb:6P6A|rcsb pdb:6P6E|rcsb pdb:6WX7|rcsb pdb:7JJM|rcsb pdb:7JK7|rcsb pdb:7JVO|rcsb pdb:7L04|reactome:R-MMU-5693548|refseq:NP_034785.1|dip:DIP-47774N|mint:MINT-6478518(identity)	-	function:Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons|comment:mint	-	figure legend:F1 T2|kinetics:kd 73 nanomolar|comment:"Importin beta 1 interacts  with interferon gamma only in presence of Importin alpha2 (preheterodimerization). The authors used the mature form (missing the first 22 amino acids) of Interferon gamma."|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/18	2014/10/16	rogid:DPL8gAtn3jVDOOBAU68pY4y0G7010090	rogid:qML5OVHqAJODiP+FSG9fTsiV3JQ10090	intact-crc:49AC7D6EF4049918|rigid:wwSN9XOCBB74z26/wHXmzi/ePKA	false	binding-associated region:23-155(MINT-6478915)	glutathione s tranferase tag:?-?(MINT-6478519)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01580	uniprotkb:P52293	intact:EBI-7892102|intact:UNK-5368977|uniprotkb:Q542B8|ensembl:ENSMUSP00000063800	intact:EBI-3043908|ensembl:ENSMUSP00000018506|ensembl:ENSMUSP00000137310|uniprotkb:Q64292	psi-mi:ifng_mouse(display_long)|uniprotkb:Ifng(gene name)|psi-mi:Ifng(display_short)	psi-mi:ima1_mouse(display_long)|uniprotkb:Kpna2(gene name)|psi-mi:Kpna2(display_short)|uniprotkb:Rch1(gene name synonym)|uniprotkb:Importin alpha P1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-2(gene name synonym)|uniprotkb:Pendulin(gene name synonym)|uniprotkb:Pore targeting complex 58 kDa subunit(gene name synonym)|uniprotkb:RAG cohort protein 1(gene name synonym)|uniprotkb:SRP1-alpha(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fulcher et al. (2008)	pubmed:18405666|imex:IM-11614|mint:MINT-6664420|doi:10.1016/j.febslet.2008.03.054	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7892434|mint:MINT-6478550|imex:IM-11614-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032363.1|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050954"(sensory perception of mechanical stimulus)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032834"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0040008"(regulation of growth)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0032747"(positive regulation of interleukin-23 production)|ensembl:ENSMUSG00000055170(gene)|ensembl:ENSMUST00000068592(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001781"(neutrophil apoptotic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002302"(CD8-positive, alpha-beta T cell differentiation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060550"(positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0060552"(positive regulation of fructose 1,6-bisphosphate metabolic process)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071351"(cellular response to interleukin-18)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072125"(negative regulation of glomerular mesangial cell proliferation)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1904440"(positive regulation of iron ion import across plasma membrane)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR002069(Interferon gamma)|interpro:IPR009079(Four-helical cytokine-like, core)|mint:P01580|reactome:R-MMU-877300|reactome:R-MMU-877312|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|mint:MINT-6478554(identity)	ensembl:ENSMUSG00000018362(gene)|ensembl:ENSMUSG00000066878(gene)|ensembl:ENSMUST00000018506(transcript)|ensembl:ENSMUST00000086423(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043657"(host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52293|rcsb pdb:1EJL|rcsb pdb:1EJY|rcsb pdb:1IAL|rcsb pdb:1IQ1|rcsb pdb:1PJM|rcsb pdb:1PJN|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1Y2A|rcsb pdb:2C1M|rcsb pdb:2YNR|rcsb pdb:3BTR|rcsb pdb:3KND|rcsb pdb:3L3Q|rcsb pdb:3OQS|rcsb pdb:3Q5U|rcsb pdb:3RZ9|rcsb pdb:3RZX|rcsb pdb:3TPM|rcsb pdb:3TPO|rcsb pdb:3UKW|rcsb pdb:3UKX|rcsb pdb:3UKZ|rcsb pdb:3UL0|rcsb pdb:3UL1|rcsb pdb:3UVU|rcsb pdb:3VE6|rcsb pdb:3ZIN|rcsb pdb:3ZIO|rcsb pdb:3ZIP|rcsb pdb:3ZIQ|rcsb pdb:3ZIR|rcsb pdb:4BA3|rcsb pdb:4HTV|rcsb pdb:4MZ5|rcsb pdb:4MZ6|rcsb pdb:4OIH|rcsb pdb:4U54|rcsb pdb:4U58|rcsb pdb:4U5L|rcsb pdb:4U5N|rcsb pdb:4U5O|rcsb pdb:4U5S|rcsb pdb:4U5U|rcsb pdb:4U5V|rcsb pdb:4UAF|rcsb pdb:4YI0|rcsb pdb:4ZDU|rcsb pdb:5B56|rcsb pdb:5CTT|rcsb pdb:5D5K|rcsb pdb:5E6Q|rcsb pdb:5EKF|rcsb pdb:5EKG|rcsb pdb:5FC8|rcsb pdb:5GXW|rcsb pdb:3UKY|rcsb pdb:5HHG|rcsb pdb:5HUW|rcsb pdb:5HUY|rcsb pdb:5K9S|rcsb pdb:5KLR|rcsb pdb:5SVZ|rcsb pdb:5U5P|rcsb pdb:5U5R|rcsb pdb:5UMZ|rcsb pdb:5V5O|rcsb pdb:5V5P|rcsb pdb:5W41|rcsb pdb:5W4E|rcsb pdb:5W4F|rcsb pdb:5W4G|rcsb pdb:5WUM|rcsb pdb:5WUN|rcsb pdb:5X8N|rcsb pdb:6BVT|rcsb pdb:6BW0|rcsb pdb:6BW1|rcsb pdb:6D7M|rcsb pdb:6D7N|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:5KLT|rcsb pdb:6IW8|rcsb pdb:6IWA|rcsb pdb:6K06|rcsb pdb:6MJL|rcsb pdb:6P6A|rcsb pdb:6P6E|rcsb pdb:6WX7|rcsb pdb:7JJM|rcsb pdb:7JK7|rcsb pdb:7JVO|rcsb pdb:7L04|reactome:R-MMU-5693548|refseq:NP_034785.1|dip:DIP-47774N|mint:MINT-6478556(identity)	-	function:Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons|comment:mint	-	figure legend:F1 T2|kinetics:kd 15 nanomolar|comment:"Importin beta 1 interacts with interferon gamma only in presence of Importin alpha2 (preheterodimerization). The authors used the mature form (missing the first 22 amino acids) of Interferon gamma."|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/18	2014/10/16	rogid:DPL8gAtn3jVDOOBAU68pY4y0G7010090	rogid:qML5OVHqAJODiP+FSG9fTsiV3JQ10090	intact-crc:1B753CA48A03D253|rigid:wwSN9XOCBB74z26/wHXmzi/ePKA	false	binding-associated region:143-154(MINT-6478563)|mutation disrupting interaction:151-151,152-152,150-150(MINT-6478567)	glutathione s tranferase tag:?-?(MINT-6478557)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01580	uniprotkb:P70168	intact:EBI-7892102|intact:UNK-5368977|uniprotkb:Q542B8|ensembl:ENSMUSP00000063800	intact:EBI-540580|uniprotkb:Q62117|uniprotkb:Q6GTI5|ensembl:ENSMUSP00000001479	psi-mi:ifng_mouse(display_long)|uniprotkb:Ifng(gene name)|psi-mi:Ifng(display_short)	psi-mi:imb1_mouse(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)|uniprotkb:SCG(gene name synonym)|uniprotkb:Kpnb1(gene name)|psi-mi:Kpnb1(display_short)|uniprotkb:Impnb(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fulcher et al. (2008)	pubmed:18405666|imex:IM-11614|mint:MINT-6664420|doi:10.1016/j.febslet.2008.03.054	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7892434|mint:MINT-6478550|imex:IM-11614-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032363.1|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050954"(sensory perception of mechanical stimulus)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032834"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0040008"(regulation of growth)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0032747"(positive regulation of interleukin-23 production)|ensembl:ENSMUSG00000055170(gene)|ensembl:ENSMUST00000068592(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001781"(neutrophil apoptotic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002302"(CD8-positive, alpha-beta T cell differentiation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060550"(positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0060552"(positive regulation of fructose 1,6-bisphosphate metabolic process)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071351"(cellular response to interleukin-18)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072125"(negative regulation of glomerular mesangial cell proliferation)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1904440"(positive regulation of iron ion import across plasma membrane)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR002069(Interferon gamma)|interpro:IPR009079(Four-helical cytokine-like, core)|mint:P01580|reactome:R-MMU-877300|reactome:R-MMU-877312|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|mint:MINT-6478554(identity)	refseq:NP_032405.3|ensembl:ENSMUSG00000001440(gene)|ensembl:ENSMUST00000001479(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|reactome:R-MMU-2995383|reactome:R-MMU-6798695|reactome:R-MMU-909733|reactome:R-MMU-1655829|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:P70168|rcsb pdb:1GCJ|rcsb pdb:1UKL|go:"GO:0019894"(kinesin binding)|reactome:R-MMU-140342|dip:DIP-33404N|mint:MINT-6478552(identity)	-	function:Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons|comment:mint	-	figure legend:F1 T2|kinetics:kd 15 nanomolar|comment:"Importin beta 1 interacts with interferon gamma only in presence of Importin alpha2 (preheterodimerization). The authors used the mature form (missing the first 22 amino acids) of Interferon gamma."|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/18	2014/10/16	rogid:DPL8gAtn3jVDOOBAU68pY4y0G7010090	rogid:rYDCcZYUZp8TbcpyJE7pfz5+bvo10090	intact-crc:1B753CA48A03D253|rigid:wwSN9XOCBB74z26/wHXmzi/ePKA	false	binding-associated region:143-154(MINT-6478563)|mutation disrupting interaction:151-151,152-152,150-150(MINT-6478567)	glutathione s tranferase tag:?-?(MINT-6489698)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52293	uniprotkb:P03070	intact:EBI-3043908|ensembl:ENSMUSP00000018506|ensembl:ENSMUSP00000137310|uniprotkb:Q64292	intact:EBI-617698	psi-mi:ima1_mouse(display_long)|uniprotkb:Kpna2(gene name)|psi-mi:Kpna2(display_short)|uniprotkb:Rch1(gene name synonym)|uniprotkb:Importin alpha P1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-2(gene name synonym)|uniprotkb:Pendulin(gene name synonym)|uniprotkb:Pore targeting complex 58 kDa subunit(gene name synonym)|uniprotkb:RAG cohort protein 1(gene name synonym)|uniprotkb:SRP1-alpha(gene name synonym)	psi-mi:lt_sv40(display_long)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fulcher et al. (2008)	pubmed:18405666|imex:IM-11614|mint:MINT-6664420|doi:10.1016/j.febslet.2008.03.054	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:1891767(sv40)|taxid:1891767(sv40)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7892355|mint:MINT-6478541|imex:IM-11614-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000018362(gene)|ensembl:ENSMUSG00000066878(gene)|ensembl:ENSMUST00000018506(transcript)|ensembl:ENSMUST00000086423(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043657"(host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52293|rcsb pdb:1EJL|rcsb pdb:1EJY|rcsb pdb:1IAL|rcsb pdb:1IQ1|rcsb pdb:1PJM|rcsb pdb:1PJN|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1Y2A|rcsb pdb:2C1M|rcsb pdb:2YNR|rcsb pdb:3BTR|rcsb pdb:3KND|rcsb pdb:3L3Q|rcsb pdb:3OQS|rcsb pdb:3Q5U|rcsb pdb:3RZ9|rcsb pdb:3RZX|rcsb pdb:3TPM|rcsb pdb:3TPO|rcsb pdb:3UKW|rcsb pdb:3UKX|rcsb pdb:3UKZ|rcsb pdb:3UL0|rcsb pdb:3UL1|rcsb pdb:3UVU|rcsb pdb:3VE6|rcsb pdb:3ZIN|rcsb pdb:3ZIO|rcsb pdb:3ZIP|rcsb pdb:3ZIQ|rcsb pdb:3ZIR|rcsb pdb:4BA3|rcsb pdb:4HTV|rcsb pdb:4MZ5|rcsb pdb:4MZ6|rcsb pdb:4OIH|rcsb pdb:4U54|rcsb pdb:4U58|rcsb pdb:4U5L|rcsb pdb:4U5N|rcsb pdb:4U5O|rcsb pdb:4U5S|rcsb pdb:4U5U|rcsb pdb:4U5V|rcsb pdb:4UAF|rcsb pdb:4YI0|rcsb pdb:4ZDU|rcsb pdb:5B56|rcsb pdb:5CTT|rcsb pdb:5D5K|rcsb pdb:5E6Q|rcsb pdb:5EKF|rcsb pdb:5EKG|rcsb pdb:5FC8|rcsb pdb:5GXW|rcsb pdb:3UKY|rcsb pdb:5HHG|rcsb pdb:5HUW|rcsb pdb:5HUY|rcsb pdb:5K9S|rcsb pdb:5KLR|rcsb pdb:5SVZ|rcsb pdb:5U5P|rcsb pdb:5U5R|rcsb pdb:5UMZ|rcsb pdb:5V5O|rcsb pdb:5V5P|rcsb pdb:5W41|rcsb pdb:5W4E|rcsb pdb:5W4F|rcsb pdb:5W4G|rcsb pdb:5WUM|rcsb pdb:5WUN|rcsb pdb:5X8N|rcsb pdb:6BVT|rcsb pdb:6BW0|rcsb pdb:6BW1|rcsb pdb:6D7M|rcsb pdb:6D7N|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:5KLT|rcsb pdb:6IW8|rcsb pdb:6IWA|rcsb pdb:6K06|rcsb pdb:6MJL|rcsb pdb:6P6A|rcsb pdb:6P6E|rcsb pdb:6WX7|rcsb pdb:7JJM|rcsb pdb:7JK7|rcsb pdb:7JVO|rcsb pdb:7L04|reactome:R-MMU-5693548|refseq:NP_034785.1|dip:DIP-47774N|mint:MINT-6478544(identity)	go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039576"(suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039686"(bidirectional double-stranded viral DNA replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003133(T antigen, Ori-binding)|interpro:IPR010932(Large T antigen, polyomavirus,  C-terminus)|interpro:IPR016392(Large T antigen, polyomaviridae)|interpro:IPR017910|interpro:IPR027417|interpro:IPR036869|rcsb pdb:1EJL|rcsb pdb:1GH6|rcsb pdb:1N25|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1SVL|rcsb pdb:1SVM|rcsb pdb:1SVO|rcsb pdb:1TBD|rcsb pdb:1Z1D|rcsb pdb:2FUF|rcsb pdb:2H1L|rcsb pdb:2IF9|rcsb pdb:2IPR|rcsb pdb:2ITJ|rcsb pdb:2ITL|rcsb pdb:2NL8|rcsb pdb:2NTC|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|rcsb pdb:2TBD|rcsb pdb:3QK2|rcsb pdb:3QN2|rcsb pdb:4E2I|rcsb pdb:4FGN|rcsb pdb:4GDF|rcsb pdb:4RXH|rcsb pdb:5D9I|refseq:YP_003708382.1|mint:P03070|dip:DIP-24251N|mint:MINT-6478543(identity)	-	-	-	figure legend:F1 T2|kinetics:kd 147 millimolar|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/18	2019/10/18	rogid:qML5OVHqAJODiP+FSG9fTsiV3JQ10090	rogid:IMcAp2PRxZXkbJ1eiXhJU9rD2JM1891767	intact-crc:7D26613EB15DCB22|rigid:jlj4zvBp2PqbbmbSxz6UwSjFc00	false	glutathione s tranferase tag:?-?(MINT-6489707)	fusion protein:?-?(MINT-6489704)|binding-associated region:111-135(MINT-6478598)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03070	uniprotkb:P52293	intact:EBI-617698	intact:EBI-3043908|ensembl:ENSMUSP00000018506|ensembl:ENSMUSP00000137310|uniprotkb:Q64292	psi-mi:lt_sv40(display_long)	psi-mi:ima1_mouse(display_long)|uniprotkb:Kpna2(gene name)|psi-mi:Kpna2(display_short)|uniprotkb:Rch1(gene name synonym)|uniprotkb:Importin alpha P1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-2(gene name synonym)|uniprotkb:Pendulin(gene name synonym)|uniprotkb:Pore targeting complex 58 kDa subunit(gene name synonym)|uniprotkb:RAG cohort protein 1(gene name synonym)|uniprotkb:SRP1-alpha(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fulcher et al. (2008)	pubmed:18405666|imex:IM-11614|mint:MINT-6664420|doi:10.1016/j.febslet.2008.03.054	taxid:1891767(sv40)|taxid:1891767(sv40)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7892542|mint:MINT-6478601|imex:IM-11614-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039576"(suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039686"(bidirectional double-stranded viral DNA replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003133(T antigen, Ori-binding)|interpro:IPR010932(Large T antigen, polyomavirus,  C-terminus)|interpro:IPR016392(Large T antigen, polyomaviridae)|interpro:IPR017910|interpro:IPR027417|interpro:IPR036869|rcsb pdb:1EJL|rcsb pdb:1GH6|rcsb pdb:1N25|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1SVL|rcsb pdb:1SVM|rcsb pdb:1SVO|rcsb pdb:1TBD|rcsb pdb:1Z1D|rcsb pdb:2FUF|rcsb pdb:2H1L|rcsb pdb:2IF9|rcsb pdb:2IPR|rcsb pdb:2ITJ|rcsb pdb:2ITL|rcsb pdb:2NL8|rcsb pdb:2NTC|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|rcsb pdb:2TBD|rcsb pdb:3QK2|rcsb pdb:3QN2|rcsb pdb:4E2I|rcsb pdb:4FGN|rcsb pdb:4GDF|rcsb pdb:4RXH|rcsb pdb:5D9I|refseq:YP_003708382.1|mint:P03070|dip:DIP-24251N|mint:MINT-6478603(identity)	ensembl:ENSMUSG00000018362(gene)|ensembl:ENSMUSG00000066878(gene)|ensembl:ENSMUST00000018506(transcript)|ensembl:ENSMUST00000086423(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043657"(host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52293|rcsb pdb:1EJL|rcsb pdb:1EJY|rcsb pdb:1IAL|rcsb pdb:1IQ1|rcsb pdb:1PJM|rcsb pdb:1PJN|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1Y2A|rcsb pdb:2C1M|rcsb pdb:2YNR|rcsb pdb:3BTR|rcsb pdb:3KND|rcsb pdb:3L3Q|rcsb pdb:3OQS|rcsb pdb:3Q5U|rcsb pdb:3RZ9|rcsb pdb:3RZX|rcsb pdb:3TPM|rcsb pdb:3TPO|rcsb pdb:3UKW|rcsb pdb:3UKX|rcsb pdb:3UKZ|rcsb pdb:3UL0|rcsb pdb:3UL1|rcsb pdb:3UVU|rcsb pdb:3VE6|rcsb pdb:3ZIN|rcsb pdb:3ZIO|rcsb pdb:3ZIP|rcsb pdb:3ZIQ|rcsb pdb:3ZIR|rcsb pdb:4BA3|rcsb pdb:4HTV|rcsb pdb:4MZ5|rcsb pdb:4MZ6|rcsb pdb:4OIH|rcsb pdb:4U54|rcsb pdb:4U58|rcsb pdb:4U5L|rcsb pdb:4U5N|rcsb pdb:4U5O|rcsb pdb:4U5S|rcsb pdb:4U5U|rcsb pdb:4U5V|rcsb pdb:4UAF|rcsb pdb:4YI0|rcsb pdb:4ZDU|rcsb pdb:5B56|rcsb pdb:5CTT|rcsb pdb:5D5K|rcsb pdb:5E6Q|rcsb pdb:5EKF|rcsb pdb:5EKG|rcsb pdb:5FC8|rcsb pdb:5GXW|rcsb pdb:3UKY|rcsb pdb:5HHG|rcsb pdb:5HUW|rcsb pdb:5HUY|rcsb pdb:5K9S|rcsb pdb:5KLR|rcsb pdb:5SVZ|rcsb pdb:5U5P|rcsb pdb:5U5R|rcsb pdb:5UMZ|rcsb pdb:5V5O|rcsb pdb:5V5P|rcsb pdb:5W41|rcsb pdb:5W4E|rcsb pdb:5W4F|rcsb pdb:5W4G|rcsb pdb:5WUM|rcsb pdb:5WUN|rcsb pdb:5X8N|rcsb pdb:6BVT|rcsb pdb:6BW0|rcsb pdb:6BW1|rcsb pdb:6D7M|rcsb pdb:6D7N|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:5KLT|rcsb pdb:6IW8|rcsb pdb:6IWA|rcsb pdb:6K06|rcsb pdb:6MJL|rcsb pdb:6P6A|rcsb pdb:6P6E|rcsb pdb:6WX7|rcsb pdb:7JJM|rcsb pdb:7JK7|rcsb pdb:7JVO|rcsb pdb:7L04|reactome:R-MMU-5693548|refseq:NP_034785.1|dip:DIP-47774N|mint:MINT-6478607(identity)	-	-	-	figure legend:F1 T2|kinetics:kd 3 nanomolar|comment:"Importin beta 1 interacts with T-ag only in presence of Importin alpha2 (preheterodimerization)."|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/18	2019/10/18	rogid:IMcAp2PRxZXkbJ1eiXhJU9rD2JM1891767	rogid:qML5OVHqAJODiP+FSG9fTsiV3JQ10090	intact-crc:D616E4E52DE1AE7F|rigid:AN5TJfvN2ja8zuZGIZrErZ+clEA	false	fusion protein:?-?(MINT-6489716)|binding-associated region:111-135(MINT-6478604)	glutathione s tranferase tag:?-?(MINT-6489713)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03070	uniprotkb:P70168	intact:EBI-617698	intact:EBI-540580|uniprotkb:Q62117|uniprotkb:Q6GTI5|ensembl:ENSMUSP00000001479	psi-mi:lt_sv40(display_long)	psi-mi:imb1_mouse(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)|uniprotkb:SCG(gene name synonym)|uniprotkb:Kpnb1(gene name)|psi-mi:Kpnb1(display_short)|uniprotkb:Impnb(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fulcher et al. (2008)	pubmed:18405666|imex:IM-11614|mint:MINT-6664420|doi:10.1016/j.febslet.2008.03.054	taxid:1891767(sv40)|taxid:1891767(sv40)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7892542|mint:MINT-6478601|imex:IM-11614-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039576"(suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039686"(bidirectional double-stranded viral DNA replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003133(T antigen, Ori-binding)|interpro:IPR010932(Large T antigen, polyomavirus,  C-terminus)|interpro:IPR016392(Large T antigen, polyomaviridae)|interpro:IPR017910|interpro:IPR027417|interpro:IPR036869|rcsb pdb:1EJL|rcsb pdb:1GH6|rcsb pdb:1N25|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1SVL|rcsb pdb:1SVM|rcsb pdb:1SVO|rcsb pdb:1TBD|rcsb pdb:1Z1D|rcsb pdb:2FUF|rcsb pdb:2H1L|rcsb pdb:2IF9|rcsb pdb:2IPR|rcsb pdb:2ITJ|rcsb pdb:2ITL|rcsb pdb:2NL8|rcsb pdb:2NTC|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|rcsb pdb:2TBD|rcsb pdb:3QK2|rcsb pdb:3QN2|rcsb pdb:4E2I|rcsb pdb:4FGN|rcsb pdb:4GDF|rcsb pdb:4RXH|rcsb pdb:5D9I|refseq:YP_003708382.1|mint:P03070|dip:DIP-24251N|mint:MINT-6478603(identity)	refseq:NP_032405.3|ensembl:ENSMUSG00000001440(gene)|ensembl:ENSMUST00000001479(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|reactome:R-MMU-2995383|reactome:R-MMU-6798695|reactome:R-MMU-909733|reactome:R-MMU-1655829|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:P70168|rcsb pdb:1GCJ|rcsb pdb:1UKL|go:"GO:0019894"(kinesin binding)|reactome:R-MMU-140342|dip:DIP-33404N|mint:MINT-6478612(identity)	-	-	-	figure legend:F1 T2|kinetics:kd 3 nanomolar|comment:"Importin beta 1 interacts with T-ag only in presence of Importin alpha2 (preheterodimerization)."|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/18	2019/10/18	rogid:IMcAp2PRxZXkbJ1eiXhJU9rD2JM1891767	rogid:rYDCcZYUZp8TbcpyJE7pfz5+bvo10090	intact-crc:D616E4E52DE1AE7F|rigid:AN5TJfvN2ja8zuZGIZrErZ+clEA	false	fusion protein:?-?(MINT-6489716)|binding-associated region:111-135(MINT-6478604)	glutathione s tranferase tag:?-?(MINT-6489710)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01580	uniprotkb:P70168	intact:EBI-7892102|intact:UNK-5368977|uniprotkb:Q542B8|ensembl:ENSMUSP00000063800	intact:EBI-540580|uniprotkb:Q62117|uniprotkb:Q6GTI5|ensembl:ENSMUSP00000001479	psi-mi:ifng_mouse(display_long)|uniprotkb:Ifng(gene name)|psi-mi:Ifng(display_short)	psi-mi:imb1_mouse(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)|uniprotkb:SCG(gene name synonym)|uniprotkb:Kpnb1(gene name)|psi-mi:Kpnb1(display_short)|uniprotkb:Impnb(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fulcher et al. (2008)	pubmed:18405666|imex:IM-11614|mint:MINT-6664420|doi:10.1016/j.febslet.2008.03.054	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7892514|mint:MINT-6478573|imex:IM-11614-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032363.1|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050954"(sensory perception of mechanical stimulus)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032834"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0040008"(regulation of growth)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0032747"(positive regulation of interleukin-23 production)|ensembl:ENSMUSG00000055170(gene)|ensembl:ENSMUST00000068592(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001781"(neutrophil apoptotic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002302"(CD8-positive, alpha-beta T cell differentiation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060550"(positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0060552"(positive regulation of fructose 1,6-bisphosphate metabolic process)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071351"(cellular response to interleukin-18)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072125"(negative regulation of glomerular mesangial cell proliferation)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1904440"(positive regulation of iron ion import across plasma membrane)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR002069(Interferon gamma)|interpro:IPR009079(Four-helical cytokine-like, core)|mint:P01580|reactome:R-MMU-877300|reactome:R-MMU-877312|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|mint:MINT-6478579(identity)	refseq:NP_032405.3|ensembl:ENSMUSG00000001440(gene)|ensembl:ENSMUST00000001479(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|reactome:R-MMU-2995383|reactome:R-MMU-6798695|reactome:R-MMU-909733|reactome:R-MMU-1655829|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:P70168|rcsb pdb:1GCJ|rcsb pdb:1UKL|go:"GO:0019894"(kinesin binding)|reactome:R-MMU-140342|dip:DIP-33404N|mint:MINT-6478587(identity)	-	function:Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons|comment:mint	-	figure legend:F1 T2|kinetics:kd 0.49 nanomolar|comment:"Importin beta 1 interacts with interferon gamma only in presence of Importin alpha2 (preheterodimerization). The authors used the mature form (missing the first 22 amino acids) of Interferon gamma."|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/18	2014/10/16	rogid:DPL8gAtn3jVDOOBAU68pY4y0G7010090	rogid:rYDCcZYUZp8TbcpyJE7pfz5+bvo10090	intact-crc:9B0C104EFDF10721|rigid:wwSN9XOCBB74z26/wHXmzi/ePKA	false	binding-associated region:117-154(MINT-6478584)	glutathione s tranferase tag:?-?(MINT-6489701)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01580	uniprotkb:P52293	intact:EBI-7892102|intact:UNK-5368977|uniprotkb:Q542B8|ensembl:ENSMUSP00000063800	intact:EBI-3043908|ensembl:ENSMUSP00000018506|ensembl:ENSMUSP00000137310|uniprotkb:Q64292	psi-mi:ifng_mouse(display_long)|uniprotkb:Ifng(gene name)|psi-mi:Ifng(display_short)	psi-mi:ima1_mouse(display_long)|uniprotkb:Kpna2(gene name)|psi-mi:Kpna2(display_short)|uniprotkb:Rch1(gene name synonym)|uniprotkb:Importin alpha P1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-2(gene name synonym)|uniprotkb:Pendulin(gene name synonym)|uniprotkb:Pore targeting complex 58 kDa subunit(gene name synonym)|uniprotkb:RAG cohort protein 1(gene name synonym)|uniprotkb:SRP1-alpha(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fulcher et al. (2008)	pubmed:18405666|imex:IM-11614|mint:MINT-6664420|doi:10.1016/j.febslet.2008.03.054	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7892514|mint:MINT-6478573|imex:IM-11614-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032363.1|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050954"(sensory perception of mechanical stimulus)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032834"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0040008"(regulation of growth)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0032747"(positive regulation of interleukin-23 production)|ensembl:ENSMUSG00000055170(gene)|ensembl:ENSMUST00000068592(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001781"(neutrophil apoptotic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002302"(CD8-positive, alpha-beta T cell differentiation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060550"(positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0060552"(positive regulation of fructose 1,6-bisphosphate metabolic process)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071351"(cellular response to interleukin-18)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072125"(negative regulation of glomerular mesangial cell proliferation)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1904440"(positive regulation of iron ion import across plasma membrane)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR002069(Interferon gamma)|interpro:IPR009079(Four-helical cytokine-like, core)|mint:P01580|reactome:R-MMU-877300|reactome:R-MMU-877312|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|mint:MINT-6478579(identity)	ensembl:ENSMUSG00000018362(gene)|ensembl:ENSMUSG00000066878(gene)|ensembl:ENSMUST00000018506(transcript)|ensembl:ENSMUST00000086423(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043657"(host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52293|rcsb pdb:1EJL|rcsb pdb:1EJY|rcsb pdb:1IAL|rcsb pdb:1IQ1|rcsb pdb:1PJM|rcsb pdb:1PJN|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1Y2A|rcsb pdb:2C1M|rcsb pdb:2YNR|rcsb pdb:3BTR|rcsb pdb:3KND|rcsb pdb:3L3Q|rcsb pdb:3OQS|rcsb pdb:3Q5U|rcsb pdb:3RZ9|rcsb pdb:3RZX|rcsb pdb:3TPM|rcsb pdb:3TPO|rcsb pdb:3UKW|rcsb pdb:3UKX|rcsb pdb:3UKZ|rcsb pdb:3UL0|rcsb pdb:3UL1|rcsb pdb:3UVU|rcsb pdb:3VE6|rcsb pdb:3ZIN|rcsb pdb:3ZIO|rcsb pdb:3ZIP|rcsb pdb:3ZIQ|rcsb pdb:3ZIR|rcsb pdb:4BA3|rcsb pdb:4HTV|rcsb pdb:4MZ5|rcsb pdb:4MZ6|rcsb pdb:4OIH|rcsb pdb:4U54|rcsb pdb:4U58|rcsb pdb:4U5L|rcsb pdb:4U5N|rcsb pdb:4U5O|rcsb pdb:4U5S|rcsb pdb:4U5U|rcsb pdb:4U5V|rcsb pdb:4UAF|rcsb pdb:4YI0|rcsb pdb:4ZDU|rcsb pdb:5B56|rcsb pdb:5CTT|rcsb pdb:5D5K|rcsb pdb:5E6Q|rcsb pdb:5EKF|rcsb pdb:5EKG|rcsb pdb:5FC8|rcsb pdb:5GXW|rcsb pdb:3UKY|rcsb pdb:5HHG|rcsb pdb:5HUW|rcsb pdb:5HUY|rcsb pdb:5K9S|rcsb pdb:5KLR|rcsb pdb:5SVZ|rcsb pdb:5U5P|rcsb pdb:5U5R|rcsb pdb:5UMZ|rcsb pdb:5V5O|rcsb pdb:5V5P|rcsb pdb:5W41|rcsb pdb:5W4E|rcsb pdb:5W4F|rcsb pdb:5W4G|rcsb pdb:5WUM|rcsb pdb:5WUN|rcsb pdb:5X8N|rcsb pdb:6BVT|rcsb pdb:6BW0|rcsb pdb:6BW1|rcsb pdb:6D7M|rcsb pdb:6D7N|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:5KLT|rcsb pdb:6IW8|rcsb pdb:6IWA|rcsb pdb:6K06|rcsb pdb:6MJL|rcsb pdb:6P6A|rcsb pdb:6P6E|rcsb pdb:6WX7|rcsb pdb:7JJM|rcsb pdb:7JK7|rcsb pdb:7JVO|rcsb pdb:7L04|reactome:R-MMU-5693548|refseq:NP_034785.1|dip:DIP-47774N|mint:MINT-6478575(identity)	-	function:Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons|comment:mint	-	figure legend:F1 T2|kinetics:kd 0.49 nanomolar|comment:"Importin beta 1 interacts with interferon gamma only in presence of Importin alpha2 (preheterodimerization). The authors used the mature form (missing the first 22 amino acids) of Interferon gamma."|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/18	2014/10/16	rogid:DPL8gAtn3jVDOOBAU68pY4y0G7010090	rogid:qML5OVHqAJODiP+FSG9fTsiV3JQ10090	intact-crc:9B0C104EFDF10721|rigid:wwSN9XOCBB74z26/wHXmzi/ePKA	false	binding-associated region:117-154(MINT-6478584)	glutathione s tranferase tag:?-?(MINT-6478576)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)