#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9JI11	uniprotkb:Q8BYR2	intact:EBI-1181352|ensembl:ENSMUSP00000018353	intact:EBI-7861349|ensembl:ENSMUSP00000041915|ensembl:ENSMUSP00000132078|ensembl:ENSMUSP00000151533|intact:UNK-5511179|uniprotkb:Q9Z0W4|uniprotkb:B2RY46	psi-mi:stk4_mouse(display_long)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Stk4(gene name)|psi-mi:Stk4(display_short)|uniprotkb:Mst1(gene name synonym)	psi-mi:lats1_mouse(display_long)|uniprotkb:Large tumor suppressor homolog 1(gene name synonym)|uniprotkb:WARTS protein kinase(gene name synonym)|uniprotkb:Lats1(gene name)|psi-mi:Lats1(display_short)|uniprotkb:Warts(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2008)	pubmed:18369314|imex:IM-11596|mint:MINT-6603949	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7861393|mint:MINT-6603968|imex:IM-11596-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067395.1|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q9JI11|reactome:R-MMU-2028269|ensembl:ENSMUSG00000018209(gene)|ensembl:ENSMUST00000018353(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|mint:MINT-6603970(identity)	ensembl:ENSMUSG00000040021(gene)|ensembl:ENSMUST00000040043(transcript)|ensembl:ENSMUST00000165952(transcript)|ensembl:ENSMUST00000217931(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0000922"(spindle pole)|go:"GO:0001827"(inner cell mass cell fate commitment)|go:"GO:0001828"(inner cell mass cellular morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051301"(cell division)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR028741|interpro:IPR042706|mint:Q8BYR2|rcsb pdb:5B6B|rcsb pdb:6J68|reactome:R-MMU-2028269|refseq:NP_034820.1|dip:DIP-47647N|mint:MINT-6603972(identity)	-	-	comment:mint|function:Tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function	figure legend:f5b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-keratinocyte)|taxid:10090(Mouse Keratinocyte)	-	2008/06/16	2014/10/16	rogid:aBZlhLOr5bIFz03KD7VAeKm1nnU10090	rogid:QQUjRviwkRB8b6/B28fc5EabGds10090	intact-crc:95B2D32E6FCECD60|rigid:BYhiVblXTwT/WXdyQzXJ0FnrTsk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JI11	uniprotkb:Q7TSJ6	intact:EBI-1181352|ensembl:ENSMUSP00000018353	intact:EBI-6305003|uniprotkb:Q8CDJ4|uniprotkb:Q9JMI3|ensembl:ENSMUSP00000022531	psi-mi:stk4_mouse(display_long)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Stk4(gene name)|psi-mi:Stk4(display_short)|uniprotkb:Mst1(gene name synonym)	psi-mi:lats2_mouse(display_long)|uniprotkb:Lats2(gene name)|psi-mi:Lats2(display_short)|uniprotkb:Kinase phosphorylated during mitosis protein(gene name synonym)|uniprotkb:Large tumor suppressor homolog 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase kpm(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2008)	pubmed:18369314|imex:IM-11596|mint:MINT-6603949	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7861393|mint:MINT-6603968|imex:IM-11596-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067395.1|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q9JI11|reactome:R-MMU-2028269|ensembl:ENSMUSG00000018209(gene)|ensembl:ENSMUST00000018353(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|mint:MINT-6603970(identity)	refseq:NP_056586.2|ensembl:ENSMUSG00000021959(gene)|ensembl:ENSMUST00000022531(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001827"(inner cell mass cell fate commitment)|go:"GO:0001828"(inner cell mass cellular morphogenesis)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028742|mint:Q7TSJ6|rcsb pdb:2COS|go:"GO:0004674"(protein serine/threonine kinase activity)|reactome:R-MMU-2028269|mint:MINT-6603971(identity)	-	-	-	figure legend:f5b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-keratinocyte)|taxid:10090(Mouse Keratinocyte)	-	2008/06/16	2014/10/16	rogid:aBZlhLOr5bIFz03KD7VAeKm1nnU10090	rogid:foHi/AG9GKSMqItv8KFJGmSo+s810090	intact-crc:95B2D32E6FCECD60|rigid:BYhiVblXTwT/WXdyQzXJ0FnrTsk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JI11	uniprotkb:Q8VEB2	intact:EBI-1181352|ensembl:ENSMUSP00000018353	intact:EBI-4284907|uniprotkb:Q9D9N9|uniprotkb:Q9ER46|ensembl:ENSMUSP00000021467	psi-mi:stk4_mouse(display_long)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Stk4(gene name)|psi-mi:Stk4(display_short)|uniprotkb:Mst1(gene name synonym)	psi-mi:sav1_mouse(display_long)|uniprotkb:Sav1(gene name)|psi-mi:Sav1(display_short)|uniprotkb:Ww45(gene name synonym)|uniprotkb:Wwp3(gene name synonym)|uniprotkb:45 kDa WW domain protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2008)	pubmed:18369314|imex:IM-11596|mint:MINT-6603949	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7861393|mint:MINT-6603968|imex:IM-11596-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067395.1|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q9JI11|reactome:R-MMU-2028269|ensembl:ENSMUSG00000018209(gene)|ensembl:ENSMUST00000018353(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|mint:MINT-6603970(identity)	refseq:NP_071311.1|go:"GO:0035329"(hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060575"(intestinal epithelial cell differentiation)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR011524(SARAH)|interpro:IPR030030|interpro:IPR036020|mint:Q8VEB2|rcsb pdb:2DWV|rcsb pdb:2YSB|rcsb pdb:7BQF|rcsb pdb:7BQG|reactome:R-MMU-2028269|go:"GO:0070699"(type II activin receptor binding)|ensembl:ENSMUSG00000021067(gene)|ensembl:ENSMUST00000021467(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030425"(dendrite)|mint:MINT-6603973(identity)	-	-	-	figure legend:f5b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-keratinocyte)|taxid:10090(Mouse Keratinocyte)	-	2008/06/16	2014/10/16	rogid:aBZlhLOr5bIFz03KD7VAeKm1nnU10090	rogid:abXHo9/0Mg8QyYksGPhP+GxtPDY10090	intact-crc:95B2D32E6FCECD60|rigid:BYhiVblXTwT/WXdyQzXJ0FnrTsk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7TSJ6	uniprotkb:Q3U9G9	intact:EBI-6305003|uniprotkb:Q8CDJ4|uniprotkb:Q9JMI3|ensembl:ENSMUSP00000022531	intact:EBI-7861464|uniprotkb:Q8VDM0|uniprotkb:Q3TSW2|intact:MINT-4112231|uniprotkb:Q811V9|uniprotkb:Q91YS5|uniprotkb:Q811V8|uniprotkb:Q91Z27|uniprotkb:Q8BST3|uniprotkb:Q8K2Y8|ensembl:ENSMUSP00000005003	psi-mi:lats2_mouse(display_long)|uniprotkb:Lats2(gene name)|psi-mi:Lats2(display_short)|uniprotkb:Kinase phosphorylated during mitosis protein(gene name synonym)|uniprotkb:Large tumor suppressor homolog 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase kpm(gene name synonym)	psi-mi:lbr_mouse(display_long)|uniprotkb:Lbr(gene name)|psi-mi:Lbr(display_short)|uniprotkb:Integral nuclear envelope inner membrane protein(gene name synonym)|uniprotkb:"3-beta-hydroxysterol Delta (14)-reductase"(gene name synonym)|uniprotkb:C-14 sterol reductase(gene name synonym)|uniprotkb:Lamin-B receptor(gene name synonym)|uniprotkb:Sterol C14-reductase(gene name synonym)	psi-mi:"MI:0027"(cosedimentation)	Lee et al. (2008)	pubmed:18369314|imex:IM-11596|mint:MINT-6603949	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7861456|mint:MINT-6603986|imex:IM-11596-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056586.2|ensembl:ENSMUSG00000021959(gene)|ensembl:ENSMUST00000022531(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001827"(inner cell mass cell fate commitment)|go:"GO:0001828"(inner cell mass cellular morphogenesis)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028742|mint:Q7TSJ6|rcsb pdb:2COS|go:"GO:0004674"(protein serine/threonine kinase activity)|reactome:R-MMU-2028269|mint:MINT-6603990(identity)	refseq:XP_017168530.1|refseq:NP_598576.2|refseq:XP_006497133.1|refseq:XP_006497134.1|ensembl:ENSMUSG00000004880(gene)|ensembl:ENSMUST00000005003(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005643"(nuclear pore)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0050613"(delta14-sterol reductase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0070402"(NADPH binding)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR002999(Tudor)|interpro:IPR018083|interpro:IPR019023|mint:Q3U9G9|reactome:R-MMU-191273|reactome:R-MMU-2995383|reactome:R-MMU-8980692|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9022692|mint:MINT-6603992(identity)	go:"GO:0005634"(nucleus)	-	comment:mint|function:Anchors the lamina and the heterochromatin to the inner nuclear membrane	figure legend:f6a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-keratinocyte)|taxid:10090(Mouse Keratinocyte)	-	2008/06/16	2014/10/16	rogid:foHi/AG9GKSMqItv8KFJGmSo+s810090	rogid:opaP1VOv6ay/1KOYq+uTcDmN6e010090	intact-crc:49B87E50DDBB370F|rigid:hDtLLn5NSz+5f+38taqAEYi6UzU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7TSJ6	uniprotkb:Q8VEB2	intact:EBI-6305003|uniprotkb:Q8CDJ4|uniprotkb:Q9JMI3|ensembl:ENSMUSP00000022531	intact:EBI-4284907|uniprotkb:Q9D9N9|uniprotkb:Q9ER46|ensembl:ENSMUSP00000021467	psi-mi:lats2_mouse(display_long)|uniprotkb:Lats2(gene name)|psi-mi:Lats2(display_short)|uniprotkb:Kinase phosphorylated during mitosis protein(gene name synonym)|uniprotkb:Large tumor suppressor homolog 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase kpm(gene name synonym)	psi-mi:sav1_mouse(display_long)|uniprotkb:Sav1(gene name)|psi-mi:Sav1(display_short)|uniprotkb:Ww45(gene name synonym)|uniprotkb:Wwp3(gene name synonym)|uniprotkb:45 kDa WW domain protein(gene name synonym)	psi-mi:"MI:0027"(cosedimentation)	Lee et al. (2008)	pubmed:18369314|imex:IM-11596|mint:MINT-6603949	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7861456|mint:MINT-6603986|imex:IM-11596-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056586.2|ensembl:ENSMUSG00000021959(gene)|ensembl:ENSMUST00000022531(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001827"(inner cell mass cell fate commitment)|go:"GO:0001828"(inner cell mass cellular morphogenesis)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028742|mint:Q7TSJ6|rcsb pdb:2COS|go:"GO:0004674"(protein serine/threonine kinase activity)|reactome:R-MMU-2028269|mint:MINT-6603990(identity)	refseq:NP_071311.1|go:"GO:0035329"(hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060575"(intestinal epithelial cell differentiation)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR011524(SARAH)|interpro:IPR030030|interpro:IPR036020|mint:Q8VEB2|rcsb pdb:2DWV|rcsb pdb:2YSB|rcsb pdb:7BQF|rcsb pdb:7BQG|reactome:R-MMU-2028269|go:"GO:0070699"(type II activin receptor binding)|ensembl:ENSMUSG00000021067(gene)|ensembl:ENSMUST00000021467(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030425"(dendrite)|mint:MINT-6603994(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:f6a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-keratinocyte)|taxid:10090(Mouse Keratinocyte)	-	2008/06/16	2014/10/16	rogid:foHi/AG9GKSMqItv8KFJGmSo+s810090	rogid:abXHo9/0Mg8QyYksGPhP+GxtPDY10090	intact-crc:49B87E50DDBB370F|rigid:hDtLLn5NSz+5f+38taqAEYi6UzU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7TSJ6	uniprotkb:Q9JI11	intact:EBI-6305003|uniprotkb:Q8CDJ4|uniprotkb:Q9JMI3|ensembl:ENSMUSP00000022531	intact:EBI-1181352|ensembl:ENSMUSP00000018353	psi-mi:lats2_mouse(display_long)|uniprotkb:Lats2(gene name)|psi-mi:Lats2(display_short)|uniprotkb:Kinase phosphorylated during mitosis protein(gene name synonym)|uniprotkb:Large tumor suppressor homolog 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase kpm(gene name synonym)	psi-mi:stk4_mouse(display_long)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Stk4(gene name)|psi-mi:Stk4(display_short)|uniprotkb:Mst1(gene name synonym)	psi-mi:"MI:0027"(cosedimentation)	Lee et al. (2008)	pubmed:18369314|imex:IM-11596|mint:MINT-6603949	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7861456|mint:MINT-6603986|imex:IM-11596-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056586.2|ensembl:ENSMUSG00000021959(gene)|ensembl:ENSMUST00000022531(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001827"(inner cell mass cell fate commitment)|go:"GO:0001828"(inner cell mass cellular morphogenesis)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028742|mint:Q7TSJ6|rcsb pdb:2COS|go:"GO:0004674"(protein serine/threonine kinase activity)|reactome:R-MMU-2028269|mint:MINT-6603990(identity)	refseq:NP_067395.1|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q9JI11|reactome:R-MMU-2028269|ensembl:ENSMUSG00000018209(gene)|ensembl:ENSMUST00000018353(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|mint:MINT-6603988(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:f6a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-keratinocyte)|taxid:10090(Mouse Keratinocyte)	-	2008/06/16	2014/10/16	rogid:foHi/AG9GKSMqItv8KFJGmSo+s810090	rogid:aBZlhLOr5bIFz03KD7VAeKm1nnU10090	intact-crc:49B87E50DDBB370F|rigid:hDtLLn5NSz+5f+38taqAEYi6UzU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7TSJ6	uniprotkb:P46938	intact:EBI-6305003|uniprotkb:Q8CDJ4|uniprotkb:Q9JMI3|ensembl:ENSMUSP00000022531	intact:EBI-1211949|uniprotkb:Q91WL1|uniprotkb:Q52KJ5|ensembl:ENSMUSP00000069554	psi-mi:lats2_mouse(display_long)|uniprotkb:Lats2(gene name)|psi-mi:Lats2(display_short)|uniprotkb:Kinase phosphorylated during mitosis protein(gene name synonym)|uniprotkb:Large tumor suppressor homolog 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase kpm(gene name synonym)	psi-mi:yap1_mouse(display_long)|uniprotkb:Yap1(gene name)|psi-mi:Yap1(display_short)|uniprotkb:Yap(gene name synonym)|uniprotkb:Yap65(gene name synonym)|uniprotkb:Protein yorkie homolog(gene name synonym)|uniprotkb:Yes-associated protein YAP65 homolog(gene name synonym)	psi-mi:"MI:0027"(cosedimentation)	Lee et al. (2008)	pubmed:18369314|imex:IM-11596|mint:MINT-6603949	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7861456|mint:MINT-6603986|imex:IM-11596-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056586.2|ensembl:ENSMUSG00000021959(gene)|ensembl:ENSMUST00000022531(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001827"(inner cell mass cell fate commitment)|go:"GO:0001828"(inner cell mass cellular morphogenesis)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028742|mint:Q7TSJ6|rcsb pdb:2COS|go:"GO:0004674"(protein serine/threonine kinase activity)|reactome:R-MMU-2028269|mint:MINT-6603990(identity)	refseq:NP_001164618.1|refseq:NP_033560.1|dip:DIP-40015N|ensembl:ENSMUSG00000053110(gene)|ensembl:ENSMUST00000065353(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001674"(female germ cell nucleus)|go:"GO:0001824"(blastocyst development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003015"(heart process)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030903"(notochord development)|go:"GO:0032570"(response to progesterone)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060242"(contact inhibition)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0072307"(regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140552"(TEAD-YAP complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902018"(negative regulation of cilium assembly)|go:"GO:1902459"(positive regulation of stem cell population maintenance)|go:"GO:1904036"(negative regulation of epithelial cell apoptotic process)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR036020|mint:P46938|rcsb pdb:3JUA|rcsb pdb:6JK0|rcsb pdb:6JK1|reactome:R-MMU-1251985|reactome:R-MMU-2028269|reactome:R-MMU-2032785|reactome:R-MMU-8939236|reactome:R-MMU-8951671|go:"GO:0035329"(hippo signaling)|mint:MINT-6604020(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:f6a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-keratinocyte)|taxid:10090(Mouse Keratinocyte)	-	2008/06/16	2014/10/16	rogid:foHi/AG9GKSMqItv8KFJGmSo+s810090	rogid:3HcM3+sEb7cqRcBxi3jCxXRjT1810090	intact-crc:49B87E50DDBB370F|rigid:hDtLLn5NSz+5f+38taqAEYi6UzU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8VEB2	uniprotkb:Q9JI11	intact:EBI-4284907|uniprotkb:Q9D9N9|uniprotkb:Q9ER46|ensembl:ENSMUSP00000021467	intact:EBI-1181352|ensembl:ENSMUSP00000018353	psi-mi:sav1_mouse(display_long)|uniprotkb:Sav1(gene name)|psi-mi:Sav1(display_short)|uniprotkb:Ww45(gene name synonym)|uniprotkb:Wwp3(gene name synonym)|uniprotkb:45 kDa WW domain protein(gene name synonym)	psi-mi:stk4_mouse(display_long)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Stk4(gene name)|psi-mi:Stk4(display_short)|uniprotkb:Mst1(gene name synonym)	psi-mi:"MI:0027"(cosedimentation)	Lee et al. (2008)	pubmed:18369314|imex:IM-11596|mint:MINT-6603949	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7861525|mint:MINT-6604025|imex:IM-11596-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071311.1|go:"GO:0035329"(hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060575"(intestinal epithelial cell differentiation)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR011524(SARAH)|interpro:IPR030030|interpro:IPR036020|mint:Q8VEB2|rcsb pdb:2DWV|rcsb pdb:2YSB|rcsb pdb:7BQF|rcsb pdb:7BQG|reactome:R-MMU-2028269|go:"GO:0070699"(type II activin receptor binding)|ensembl:ENSMUSG00000021067(gene)|ensembl:ENSMUST00000021467(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030425"(dendrite)|mint:MINT-6604036(identity)	refseq:NP_067395.1|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q9JI11|reactome:R-MMU-2028269|ensembl:ENSMUSG00000018209(gene)|ensembl:ENSMUST00000018353(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|mint:MINT-6604030(identity)	go:"GO:0005737"(cytoplasm)	-	-	figure legend:f6a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-keratinocyte)|taxid:10090(Mouse Keratinocyte)	-	2008/06/16	2014/10/16	rogid:abXHo9/0Mg8QyYksGPhP+GxtPDY10090	rogid:aBZlhLOr5bIFz03KD7VAeKm1nnU10090	intact-crc:9ACA67A8A8256DFB|rigid:WNlU2fQE/N9eT/MGRJowJTQj9S8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8VEB2	uniprotkb:P68369	intact:EBI-4284907|uniprotkb:Q9D9N9|uniprotkb:Q9ER46|ensembl:ENSMUSP00000021467	intact:EBI-400542|uniprotkb:P02551|uniprotkb:P05210|uniprotkb:P05212|uniprotkb:Q3TGF0|uniprotkb:Q3TIW2|uniprotkb:Q3TPJ1|uniprotkb:Q3ULN1|uniprotkb:Q5XJF8|ensembl:ENSMUSP00000094778	psi-mi:sav1_mouse(display_long)|uniprotkb:Sav1(gene name)|psi-mi:Sav1(display_short)|uniprotkb:Ww45(gene name synonym)|uniprotkb:Wwp3(gene name synonym)|uniprotkb:45 kDa WW domain protein(gene name synonym)	psi-mi:tba1a_mouse(display_long)|uniprotkb:Tuba1a(gene name)|psi-mi:Tuba1a(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:Alpha-tubulin isotype M-alpha-1(gene name synonym)|uniprotkb:Tuba1(gene name synonym)	psi-mi:"MI:0027"(cosedimentation)	Lee et al. (2008)	pubmed:18369314|imex:IM-11596|mint:MINT-6603949	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7861525|mint:MINT-6604025|imex:IM-11596-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071311.1|go:"GO:0035329"(hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060575"(intestinal epithelial cell differentiation)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR011524(SARAH)|interpro:IPR030030|interpro:IPR036020|mint:Q8VEB2|rcsb pdb:2DWV|rcsb pdb:2YSB|rcsb pdb:7BQF|rcsb pdb:7BQG|reactome:R-MMU-2028269|go:"GO:0070699"(type II activin receptor binding)|ensembl:ENSMUSG00000021067(gene)|ensembl:ENSMUST00000021467(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030425"(dendrite)|mint:MINT-6604036(identity)	refseq:NP_035783.1|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-437239|reactome:R-MMU-5610787|reactome:R-MMU-5617833|reactome:R-MMU-5620912|reactome:R-MMU-5620924|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8955332|reactome:R-MMU-9646399|reactome:R-MMU-9648025|reactome:R-MMU-9668328|reactome:R-MMU-983189|ensembl:ENSMUSG00000072235(gene)|ensembl:ENSMUST00000097014(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0055037"(recycling endosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68369|rcsb pdb:6JZD|reactome:R-MMU-190840|reactome:R-MMU-2132295|mint:MINT-6604028(identity)	go:"GO:0005737"(cytoplasm)	-	-	figure legend:f6a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-keratinocyte)|taxid:10090(Mouse Keratinocyte)	-	2008/06/16	2014/10/16	rogid:abXHo9/0Mg8QyYksGPhP+GxtPDY10090	rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY10090	intact-crc:9ACA67A8A8256DFB|rigid:WNlU2fQE/N9eT/MGRJowJTQj9S8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)