#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P34707-3 uniprotkb:Q17941 intact:EBI-434993|ensemblmetazoa:T19E7.2c.1|ensemblmetazoa:T19E7.2c.2|ensemblmetazoa:T19E7.2c.3 intact:EBI-1770718|uniprotkb:Q17942|uniprotkb:Q8MQE0|ensemblmetazoa:C12D8.10a.1|ensemblmetazoa:C12D8.10a.2 psi-mi:p34707-3(display_long)|uniprotkb:skn-1(gene name)|psi-mi:skn-1(display_short)|uniprotkb:T19E7.2(orf name) psi-mi:akt1_caeel(display_long)|uniprotkb:akt-1(gene name)|psi-mi:akt-1(display_short)|uniprotkb:C12D8.10(orf name)|uniprotkb:Protein kinase B akt-1(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Tullet et al. (2008) imex:IM-11912|pubmed:18358814 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1770659|imex:IM-11912-2 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-319213(skn1_caeel)|ensemblmetazoa:T19E7.2c.1(transcript)|ensemblmetazoa:T19E7.2c.2(transcript)|ensemblmetazoa:T19E7.2c.3(transcript)|ensemblmetazoa:WBGene00004804(gene) refseq:NP_001023645.1|refseq:NP_001023646.1|refseq:NP_001023647.1|wormbase:C12D8.10a|wormbase:C12D8.10b|wormbase:C12D8.10c|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR039026|mint:Q17941|ensemblmetazoa:C12D8.10a.1(transcript)|ensemblmetazoa:C12D8.10a.2(transcript)|ensemblmetazoa:WBGene00000102(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902074"(response to salt)|reactome:R-CEL-1257604|reactome:R-CEL-1474151|reactome:R-CEL-165158|reactome:R-CEL-165159|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-203615|reactome:R-CEL-211163|reactome:R-CEL-389357|reactome:R-CEL-389513|reactome:R-CEL-392451|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-5218920|reactome:R-CEL-6811558|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8849469|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240|reactome:R-CEL-9614399|reactome:R-CEL-9634638 psi-mi:"MI:0469"(intact) isoform-comment:No experimental confirmation available. - resulting-ptm:Phosphorylation of SKN1C|figure legend:Fig. 2C, 2F, Supp. Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/05/06 2014/10/16 rogid:MVExz5NJyBaPjJ4mNlKQinNs7c46239 rogid:Lbru/j15mbtFfQv0kZ3xFS+32Hs6239 intact-crc:5044F865BC95B518|rigid:IrBJHtg53rqdjzY5mecl2xqqIVA false glutathione s tranferase tag:?-?|sufficient binding region:91-260 green fluorescent protein tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P34707-3 uniprotkb:Q9XTG7 intact:EBI-434993|ensemblmetazoa:T19E7.2c.1|ensemblmetazoa:T19E7.2c.2|ensemblmetazoa:T19E7.2c.3 intact:EBI-320656|uniprotkb:O77145|ensemblmetazoa:F28H6.1a.1 psi-mi:p34707-3(display_long)|uniprotkb:skn-1(gene name)|psi-mi:skn-1(display_short)|uniprotkb:T19E7.2(orf name) psi-mi:akt2_caeel(display_long)|uniprotkb:akt-2(gene name)|psi-mi:akt-2(display_short)|uniprotkb:Protein kinase B akt-2(gene name synonym)|uniprotkb:F28H6.1(orf name) psi-mi:"MI:0424"(protein kinase assay) Tullet et al. (2008) imex:IM-11912|pubmed:18358814 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1770766|imex:IM-11912-5 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-319213(skn1_caeel)|ensemblmetazoa:T19E7.2c.1(transcript)|ensemblmetazoa:T19E7.2c.2(transcript)|ensemblmetazoa:T19E7.2c.3(transcript)|ensemblmetazoa:WBGene00004804(gene) refseq:NP_510357.3|wormbase:F28H6.1a|wormbase:F28H6.1b|reactome:R-CEL-392451|refseq:NP_001024612.1|ensemblmetazoa:F28H6.1a.1(transcript)|ensemblmetazoa:WBGene00000103(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR039026|go:"GO:0045087"(innate immune response)|reactome:R-CEL-165158|reactome:R-CEL-1257604|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-389357|reactome:R-CEL-5218920|dip:DIP-26368N|reactome:R-CEL-9634638|reactome:R-CEL-211163|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9614399|reactome:R-CEL-1474151|reactome:R-CEL-165159|reactome:R-CEL-203615|reactome:R-CEL-389513|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-6811558|reactome:R-CEL-8849469|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240 psi-mi:"MI:0469"(intact) isoform-comment:No experimental confirmation available. - resulting-ptm:Phosphorylation of SKN1C on Ser-171|figure legend:Fig. 2C, 2F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/05/06 2014/10/16 rogid:MVExz5NJyBaPjJ4mNlKQinNs7c46239 rogid:Y8D47LHcNyTK3JpkYGj9/UCRYKs6239 intact-crc:B14C4C91D73A40D2|rigid:/RjBjdewpHli5wIYeNywllzCVzw false glutathione s tranferase tag:?-?|sufficient binding region:91-260 green fluorescent protein tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P34707-3 uniprotkb:Q2PJ68 intact:EBI-434993|ensemblmetazoa:T19E7.2c.1|ensemblmetazoa:T19E7.2c.2|ensemblmetazoa:T19E7.2c.3 intact:EBI-1770776|uniprotkb:Q2PJ69|ensemblmetazoa:W10G6.2b.1 psi-mi:p34707-3(display_long)|uniprotkb:skn-1(gene name)|psi-mi:skn-1(display_short)|uniprotkb:T19E7.2(orf name) psi-mi:sgk1_caeel(display_long)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)|uniprotkb:sgk-1(gene name)|psi-mi:sgk-1(display_short)|uniprotkb:W10G6.2(orf name)|uniprotkb:Serum- and glucocorticoid-inducible kinase homolog(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Tullet et al. (2008) imex:IM-11912|pubmed:18358814 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1770791|imex:IM-11912-3 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-319213(skn1_caeel)|ensemblmetazoa:T19E7.2c.1(transcript)|ensemblmetazoa:T19E7.2c.2(transcript)|ensemblmetazoa:T19E7.2c.3(transcript)|ensemblmetazoa:WBGene00004804(gene) reactome:R-CEL-6804757|refseq:NP_001041298.1|refseq:NP_001041299.1|wormbase:W10G6.2a|wormbase:W10G6.2b|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2672351|reactome:R-CEL-9031628|ensemblmetazoa:W10G6.2b.1(transcript)|ensemblmetazoa:WBGene00004789(gene)|go:"GO:0002119"(nematode larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048382"(mesendoderm development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903188"(positive regulation of vitellogenesis)|go:"GO:1904508"(regulation of protein localization to basolateral plasma membrane) psi-mi:"MI:0469"(intact) isoform-comment:No experimental confirmation available. - resulting-ptm:Phosphorylation of SKN1C on Ser-171, Thr-177, Ser-470, Ser-487, Ser-521|figure legend:Fig. 2C, 2F, 2G,|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/05/06 2014/10/16 rogid:MVExz5NJyBaPjJ4mNlKQinNs7c46239 rogid:ngczdO33Sry0fNHG63cFjKsegn46239 intact-crc:8ED4B3070FCBFDDF|rigid:Nxw8/lrvxSkDLSbeNgR5sBX2ed8 false glutathione s tranferase tag:?-?|sufficient binding region:91-260 green fluorescent protein tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P34707-1 uniprotkb:Q17941 intact:EBI-434984|ensemblmetazoa:T19E7.2a.1 intact:EBI-1770718|uniprotkb:Q17942|uniprotkb:Q8MQE0|ensemblmetazoa:C12D8.10a.1|ensemblmetazoa:C12D8.10a.2 psi-mi:p34707-1(display_long)|uniprotkb:skn-1(gene name)|psi-mi:skn-1(display_short)|uniprotkb:T19E7.2(orf name) psi-mi:akt1_caeel(display_long)|uniprotkb:akt-1(gene name)|psi-mi:akt-1(display_short)|uniprotkb:C12D8.10(orf name)|uniprotkb:Protein kinase B akt-1(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Tullet et al. (2008) imex:IM-11912|pubmed:18358814 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1770802|imex:IM-11912-1 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-319213(skn1_caeel)|ensemblmetazoa:T19E7.2a.1(transcript)|ensemblmetazoa:WBGene00004804(gene) refseq:NP_001023645.1|refseq:NP_001023646.1|refseq:NP_001023647.1|wormbase:C12D8.10a|wormbase:C12D8.10b|wormbase:C12D8.10c|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR039026|mint:Q17941|ensemblmetazoa:C12D8.10a.1(transcript)|ensemblmetazoa:C12D8.10a.2(transcript)|ensemblmetazoa:WBGene00000102(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902074"(response to salt)|reactome:R-CEL-1257604|reactome:R-CEL-1474151|reactome:R-CEL-165158|reactome:R-CEL-165159|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-203615|reactome:R-CEL-211163|reactome:R-CEL-389357|reactome:R-CEL-389513|reactome:R-CEL-392451|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-5218920|reactome:R-CEL-6811558|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8849469|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240|reactome:R-CEL-9614399|reactome:R-CEL-9634638 psi-mi:"MI:0469"(intact) - - resulting-ptm:Phosphorylation of SKN1A on Ser-10, Ser-28, Ser-78|figure legend:Fig. 2D, 2E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/05/06 2014/10/16 rogid:N+x6NUg+thGahkVDU78sb9jHYuM6239 rogid:Lbru/j15mbtFfQv0kZ3xFS+32Hs6239 intact-crc:6250D15BFD9D9312|rigid:4BjfoTfQ+KYynfBLhUIdUnp2AiQ false glutathione s tranferase tag:?-?|sufficient binding region:1-90 green fluorescent protein tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P34707-1 uniprotkb:Q9XTG7 intact:EBI-434984|ensemblmetazoa:T19E7.2a.1 intact:EBI-320656|uniprotkb:O77145|ensemblmetazoa:F28H6.1a.1 psi-mi:p34707-1(display_long)|uniprotkb:skn-1(gene name)|psi-mi:skn-1(display_short)|uniprotkb:T19E7.2(orf name) psi-mi:akt2_caeel(display_long)|uniprotkb:akt-2(gene name)|psi-mi:akt-2(display_short)|uniprotkb:Protein kinase B akt-2(gene name synonym)|uniprotkb:F28H6.1(orf name) psi-mi:"MI:0424"(protein kinase assay) Tullet et al. (2008) imex:IM-11912|pubmed:18358814 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1770812|imex:IM-11912-4 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-319213(skn1_caeel)|ensemblmetazoa:T19E7.2a.1(transcript)|ensemblmetazoa:WBGene00004804(gene) refseq:NP_510357.3|wormbase:F28H6.1a|wormbase:F28H6.1b|reactome:R-CEL-392451|refseq:NP_001024612.1|ensemblmetazoa:F28H6.1a.1(transcript)|ensemblmetazoa:WBGene00000103(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR039026|go:"GO:0045087"(innate immune response)|reactome:R-CEL-165158|reactome:R-CEL-1257604|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-389357|reactome:R-CEL-5218920|dip:DIP-26368N|reactome:R-CEL-9634638|reactome:R-CEL-211163|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9614399|reactome:R-CEL-1474151|reactome:R-CEL-165159|reactome:R-CEL-203615|reactome:R-CEL-389513|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-6811558|reactome:R-CEL-8849469|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240 psi-mi:"MI:0469"(intact) - - resulting-ptm:Phosphorylation of SKN1C on Ser-12|figure legend:Fig. 2D, 2E,|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/05/06 2014/10/16 rogid:N+x6NUg+thGahkVDU78sb9jHYuM6239 rogid:Y8D47LHcNyTK3JpkYGj9/UCRYKs6239 intact-crc:C3C609EE449B092B|rigid:j1BHBVvxsTuBqBhOZ8Ph1pK9aAI false glutathione s tranferase tag:?-?|sufficient binding region:1-90 green fluorescent protein tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:O16850 uniprotkb:Q2PJ68 intact:EBI-324028|uniprotkb:O16849|uniprotkb:O18676|uniprotkb:Q86S42|intact:EBI-1770827|uniprotkb:F3NWW7|uniprotkb:F3NWX0|uniprotkb:G4RQR7|uniprotkb:G4S686|uniprotkb:G4SKG3|uniprotkb:G4SKH0|ensemblmetazoa:R13H8.1h.1 intact:EBI-1770776|uniprotkb:Q2PJ69|ensemblmetazoa:W10G6.2b.1 psi-mi:foxo_caeel(display_long)|uniprotkb:Abnormal dauer formation protein 16(gene name synonym)|uniprotkb:daf-16(gene name)|psi-mi:daf-16(display_short)|uniprotkb:R13H8.1(orf name) psi-mi:sgk1_caeel(display_long)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)|uniprotkb:sgk-1(gene name)|psi-mi:sgk-1(display_short)|uniprotkb:W10G6.2(orf name)|uniprotkb:Serum- and glucocorticoid-inducible kinase homolog(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Tullet et al. (2008) imex:IM-11912|pubmed:18358814 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1770843|imex:IM-11912-8 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001021593.1|refseq:NP_001021594.1|refseq:NP_001021595.1|refseq:NP_001021597.1|wormbase:R13H8.1a|wormbase:R13H8.1b|wormbase:R13H8.1c|wormbase:R13H8.1e|refseq:NP_001021596.1|reactome:R-CEL-9607240|refseq:NP_001021598.2|refseq:NP_001251490.1|refseq:NP_001251492.1|reactome:R-CEL-9614399|reactome:R-CEL-9615017|reactome:R-CEL-9617629|wormbase:R13H8.1d|wormbase:R13H8.1f|wormbase:R13H8.1g|wormbase:R13H8.1h|ensemblmetazoa:R13H8.1h.1(transcript)|ensemblmetazoa:WBGene00000912(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002119"(nematode larval development)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007614"(short-term memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009411"(response to UV)|go:"GO:0010286"(heat acclimation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040024"(dauer larval development)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060537"(muscle tissue development)|go:"GO:0061065"(regulation of dauer larval development)|go:"GO:0061066"(positive regulation of dauer larval development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900075"(positive regulation of neuromuscular synaptic transmission)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1905909"(regulation of dauer entry)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|go:"GO:0045087"(innate immune response)|reactome:R-CEL-198693|reactome:R-CEL-211163|reactome:R-CEL-5687128|dip:DIP-25581N|reactome:R-CEL-5689880|reactome:R-CEL-1181150|reactome:R-CEL-9617828|reactome:R-CEL-9634638 reactome:R-CEL-6804757|refseq:NP_001041298.1|refseq:NP_001041299.1|wormbase:W10G6.2a|wormbase:W10G6.2b|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2672351|reactome:R-CEL-9031628|ensemblmetazoa:W10G6.2b.1(transcript)|ensemblmetazoa:WBGene00004789(gene)|go:"GO:0002119"(nematode larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048382"(mesendoderm development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903188"(positive regulation of vitellogenesis)|go:"GO:1904508"(regulation of protein localization to basolateral plasma membrane) psi-mi:"MI:0469"(intact) - - resulting-ptm:Phosphorylation of DAF16|figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/05/06 2014/10/16 rogid:UfAMA8NPgcJv93n6XAjW5mLboZQ6239 rogid:ngczdO33Sry0fNHG63cFjKsegn46239 intact-crc:7650D5202ED375AE|rigid:21e4TpoNrajtb1ZnWT35+afA0yU false glutathione s tranferase tag:?-? green fluorescent protein tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q17941 uniprotkb:O16850 intact:EBI-1770718|uniprotkb:Q17942|uniprotkb:Q8MQE0|ensemblmetazoa:C12D8.10a.1|ensemblmetazoa:C12D8.10a.2 intact:EBI-324028|uniprotkb:O16849|uniprotkb:O18676|uniprotkb:Q86S42|intact:EBI-1770827|uniprotkb:F3NWW7|uniprotkb:F3NWX0|uniprotkb:G4RQR7|uniprotkb:G4S686|uniprotkb:G4SKG3|uniprotkb:G4SKH0|ensemblmetazoa:R13H8.1h.1 psi-mi:akt1_caeel(display_long)|uniprotkb:akt-1(gene name)|psi-mi:akt-1(display_short)|uniprotkb:C12D8.10(orf name)|uniprotkb:Protein kinase B akt-1(gene name synonym) psi-mi:foxo_caeel(display_long)|uniprotkb:Abnormal dauer formation protein 16(gene name synonym)|uniprotkb:daf-16(gene name)|psi-mi:daf-16(display_short)|uniprotkb:R13H8.1(orf name) psi-mi:"MI:0424"(protein kinase assay) Tullet et al. (2008) imex:IM-11912|pubmed:18358814 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1770851|imex:IM-11912-6 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001023645.1|refseq:NP_001023646.1|refseq:NP_001023647.1|wormbase:C12D8.10a|wormbase:C12D8.10b|wormbase:C12D8.10c|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR039026|mint:Q17941|ensemblmetazoa:C12D8.10a.1(transcript)|ensemblmetazoa:C12D8.10a.2(transcript)|ensemblmetazoa:WBGene00000102(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902074"(response to salt)|reactome:R-CEL-1257604|reactome:R-CEL-1474151|reactome:R-CEL-165158|reactome:R-CEL-165159|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-203615|reactome:R-CEL-211163|reactome:R-CEL-389357|reactome:R-CEL-389513|reactome:R-CEL-392451|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-5218920|reactome:R-CEL-6811558|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8849469|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240|reactome:R-CEL-9614399|reactome:R-CEL-9634638 refseq:NP_001021593.1|refseq:NP_001021594.1|refseq:NP_001021595.1|refseq:NP_001021597.1|wormbase:R13H8.1a|wormbase:R13H8.1b|wormbase:R13H8.1c|wormbase:R13H8.1e|refseq:NP_001021596.1|reactome:R-CEL-9607240|refseq:NP_001021598.2|refseq:NP_001251490.1|refseq:NP_001251492.1|reactome:R-CEL-9614399|reactome:R-CEL-9615017|reactome:R-CEL-9617629|wormbase:R13H8.1d|wormbase:R13H8.1f|wormbase:R13H8.1g|wormbase:R13H8.1h|ensemblmetazoa:R13H8.1h.1(transcript)|ensemblmetazoa:WBGene00000912(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002119"(nematode larval development)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007614"(short-term memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009411"(response to UV)|go:"GO:0010286"(heat acclimation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040024"(dauer larval development)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060537"(muscle tissue development)|go:"GO:0061065"(regulation of dauer larval development)|go:"GO:0061066"(positive regulation of dauer larval development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900075"(positive regulation of neuromuscular synaptic transmission)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1905909"(regulation of dauer entry)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|go:"GO:0045087"(innate immune response)|reactome:R-CEL-198693|reactome:R-CEL-211163|reactome:R-CEL-5687128|dip:DIP-25581N|reactome:R-CEL-5689880|reactome:R-CEL-1181150|reactome:R-CEL-9617828|reactome:R-CEL-9634638 psi-mi:"MI:0469"(intact) - - resulting-ptm:Phosphorylation of DAF-16|figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/05/06 2014/10/16 rogid:Lbru/j15mbtFfQv0kZ3xFS+32Hs6239 rogid:UfAMA8NPgcJv93n6XAjW5mLboZQ6239 intact-crc:BBBBA7D1D067ED77|rigid:i9XRxd1yDYpUfFzltbHwudiZ2uo false green fluorescent protein tag:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9XTG7 uniprotkb:O16850 intact:EBI-320656|uniprotkb:O77145|ensemblmetazoa:F28H6.1a.1 intact:EBI-324028|uniprotkb:O16849|uniprotkb:O18676|uniprotkb:Q86S42|intact:EBI-1770827|uniprotkb:F3NWW7|uniprotkb:F3NWX0|uniprotkb:G4RQR7|uniprotkb:G4S686|uniprotkb:G4SKG3|uniprotkb:G4SKH0|ensemblmetazoa:R13H8.1h.1 psi-mi:akt2_caeel(display_long)|uniprotkb:akt-2(gene name)|psi-mi:akt-2(display_short)|uniprotkb:Protein kinase B akt-2(gene name synonym)|uniprotkb:F28H6.1(orf name) psi-mi:foxo_caeel(display_long)|uniprotkb:Abnormal dauer formation protein 16(gene name synonym)|uniprotkb:daf-16(gene name)|psi-mi:daf-16(display_short)|uniprotkb:R13H8.1(orf name) psi-mi:"MI:0424"(protein kinase assay) Tullet et al. (2008) imex:IM-11912|pubmed:18358814 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1770856|imex:IM-11912-7 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_510357.3|wormbase:F28H6.1a|wormbase:F28H6.1b|reactome:R-CEL-392451|refseq:NP_001024612.1|ensemblmetazoa:F28H6.1a.1(transcript)|ensemblmetazoa:WBGene00000103(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR039026|go:"GO:0045087"(innate immune response)|reactome:R-CEL-165158|reactome:R-CEL-1257604|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-389357|reactome:R-CEL-5218920|dip:DIP-26368N|reactome:R-CEL-9634638|reactome:R-CEL-211163|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9614399|reactome:R-CEL-1474151|reactome:R-CEL-165159|reactome:R-CEL-203615|reactome:R-CEL-389513|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-6811558|reactome:R-CEL-8849469|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240 refseq:NP_001021593.1|refseq:NP_001021594.1|refseq:NP_001021595.1|refseq:NP_001021597.1|wormbase:R13H8.1a|wormbase:R13H8.1b|wormbase:R13H8.1c|wormbase:R13H8.1e|refseq:NP_001021596.1|reactome:R-CEL-9607240|refseq:NP_001021598.2|refseq:NP_001251490.1|refseq:NP_001251492.1|reactome:R-CEL-9614399|reactome:R-CEL-9615017|reactome:R-CEL-9617629|wormbase:R13H8.1d|wormbase:R13H8.1f|wormbase:R13H8.1g|wormbase:R13H8.1h|ensemblmetazoa:R13H8.1h.1(transcript)|ensemblmetazoa:WBGene00000912(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002119"(nematode larval development)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007614"(short-term memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009411"(response to UV)|go:"GO:0010286"(heat acclimation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040024"(dauer larval development)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060537"(muscle tissue development)|go:"GO:0061065"(regulation of dauer larval development)|go:"GO:0061066"(positive regulation of dauer larval development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900075"(positive regulation of neuromuscular synaptic transmission)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1905909"(regulation of dauer entry)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|go:"GO:0045087"(innate immune response)|reactome:R-CEL-198693|reactome:R-CEL-211163|reactome:R-CEL-5687128|dip:DIP-25581N|reactome:R-CEL-5689880|reactome:R-CEL-1181150|reactome:R-CEL-9617828|reactome:R-CEL-9634638 psi-mi:"MI:0469"(intact) - - resulting-ptm:Phosphorylation of DAf16|figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/05/06 2014/10/16 rogid:Y8D47LHcNyTK3JpkYGj9/UCRYKs6239 rogid:UfAMA8NPgcJv93n6XAjW5mLboZQ6239 intact-crc:C76CCA42A59F3131|rigid:6Gay1LRzU1w7M7nm4AvpTN8r9+s false green fluorescent protein tag:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)