#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UKJ1 uniprotkb:P06436 intact:EBI-965833|ensembl:ENSP00000198536|uniprotkb:Q8NHI1 intact:EBI-1771271 psi-mi:pilra_human(display_long)|uniprotkb:PILRA(gene name)|psi-mi:PILRA(display_short)|uniprotkb:Inhibitory receptor PILR-alpha(gene name synonym)|uniprotkb:Cell surface receptor FDF03(gene name synonym) psi-mi:gb_hhv1f(display_long)|uniprotkb:gB(gene name)|psi-mi:gB(display_short)|uniprotkb:UL27(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Satoh et al. (2008) imex:IM-11914|pubmed:18358807 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10304(hhv1f)|taxid:10304("Human herpesvirus 1 (strain F) (HHV-1)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1771285|imex:IM-11914-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000085514(gene)|ensembl:ENST00000198536(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3WUZ|rcsb pdb:3WV0|rcsb pdb:4NFB|rcsb pdb:5XO2|rcsb pdb:5XOF|reactome:R-HSA-198933|refseq:NP_038467.2|refseq:NP_840056.1|refseq:NP_840057.1 interpro:IPR000234(Herpesvirus Glycoprotein B)|rcsb pdb:1RJY|rcsb pdb:1RJZ|rcsb pdb:1RK0|rcsb pdb:1RK1|rcsb pdb:1T0M|rcsb pdb:1T0N|interpro:IPR035377|interpro:IPR035381|interpro:IPR038631|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane) go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 1 B and Supp Fig. 1|comment:An additional 2 peptides corresponding to Glycoprotein H were also identified.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/05/07 2014/10/16 rogid:QWSaRQHGXRXAOOMvijnTQztvSpY9606 rogid:TaQY+rnyeBFc5Quy6JBHq1N6JLk10304 intact-crc:AE2EA7EB3349720C false - - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q9UKJ1 intact:EBI-1771288 intact:EBI-965833|ensembl:ENSP00000198536|uniprotkb:Q8NHI1 - psi-mi:pilra_human(display_long)|uniprotkb:PILRA(gene name)|psi-mi:PILRA(display_short)|uniprotkb:Inhibitory receptor PILR-alpha(gene name synonym)|uniprotkb:Cell surface receptor FDF03(gene name synonym) psi-mi:vglh_hhv1f_protein(display_short)|psi-mi:EBI-1771288(display_long) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Satoh et al. (2008) imex:IM-11914|pubmed:18358807 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10304(hhv1f)|taxid:10304("Human herpesvirus 1 (strain F) (HHV-1)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1771285|imex:IM-11914-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000085514(gene)|ensembl:ENST00000198536(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3WUZ|rcsb pdb:3WV0|rcsb pdb:4NFB|rcsb pdb:5XO2|rcsb pdb:5XOF|reactome:R-HSA-198933|refseq:NP_038467.2|refseq:NP_840056.1|refseq:NP_840057.1 - go:"GO:0019048"(modulation by virus of host process) - no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Similar to P06477 figure legend:Fig. 1 B and Supp Fig. 1|comment:An additional 2 peptides corresponding to Glycoprotein H were also identified.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/05/07 2014/10/16 rogid:QWSaRQHGXRXAOOMvijnTQztvSpY9606 - intact-crc:AE2EA7EB3349720C false - - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q9UKJ1 uniprotkb:P06436 intact:EBI-965833|ensembl:ENSP00000198536|uniprotkb:Q8NHI1 intact:EBI-1771271 psi-mi:pilra_human(display_long)|uniprotkb:PILRA(gene name)|psi-mi:PILRA(display_short)|uniprotkb:Inhibitory receptor PILR-alpha(gene name synonym)|uniprotkb:Cell surface receptor FDF03(gene name synonym) psi-mi:gb_hhv1f(display_long)|uniprotkb:gB(gene name)|psi-mi:gB(display_short)|uniprotkb:UL27(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Satoh et al. (2008) imex:IM-11914|pubmed:18358807 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10304(hhv1f)|taxid:10304("Human herpesvirus 1 (strain F) (HHV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1771301|imex:IM-11914-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000085514(gene)|ensembl:ENST00000198536(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3WUZ|rcsb pdb:3WV0|rcsb pdb:4NFB|rcsb pdb:5XO2|rcsb pdb:5XOF|reactome:R-HSA-198933|refseq:NP_038467.2|refseq:NP_840056.1|refseq:NP_840057.1 interpro:IPR000234(Herpesvirus Glycoprotein B)|rcsb pdb:1RJY|rcsb pdb:1RJZ|rcsb pdb:1RK0|rcsb pdb:1RK1|rcsb pdb:1T0M|rcsb pdb:1T0N|interpro:IPR035377|interpro:IPR035381|interpro:IPR038631|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane) go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 1 C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/05/07 2014/10/16 rogid:QWSaRQHGXRXAOOMvijnTQztvSpY9606 rogid:TaQY+rnyeBFc5Quy6JBHq1N6JLk10304 intact-crc:2FFEF5B2041342E8|rigid:wtmEv/2YZSAQEE+RvoPFBnGCB8E false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-1771356 uniprotkb:Q15223 - intact:EBI-1771314|uniprotkb:O75465|uniprotkb:Q2M3D3|uniprotkb:Q9HBE6|uniprotkb:Q9HBW2|ensembl:ENSP00000264025 psi-mi:vgld_hhv1f_protein(display_short)|psi-mi:EBI-1771356(display_long) psi-mi:nect1_human(display_long)|uniprotkb:NECTIN1(gene name)|psi-mi:NECTIN1(display_short)|uniprotkb:HVEC(gene name synonym)|uniprotkb:Herpes virus entry mediator C(gene name synonym)|uniprotkb:Herpesvirus Ig-like receptor(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 1(gene name synonym)|uniprotkb:PRR1(gene name synonym)|uniprotkb:PVRL1(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Satoh et al. (2008) imex:IM-11914|pubmed:18358807 taxid:10304(hhv1f)|taxid:10304("Human herpesvirus 1 (strain F) (HHV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1771305|imex:IM-11914-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_002846.3|refseq:NP_976030.1|refseq:NP_976031.1|dip:DIP-40302N|ensembl:ENSG00000110400(gene)|ensembl:ENST00000264025(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0002934"(desmosome organization)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006826"(iron ion transport)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070166"(enamel mineralization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033314|interpro:IPR036179|interpro:IPR041849|interpro:IPR041850|rcsb pdb:3ALP|rcsb pdb:3SKU|rcsb pdb:3U82|rcsb pdb:3U83|rcsb pdb:4FMF|rcsb pdb:4MYW|reactome:R-HSA-418990|reactome:R-HSA-420597 go:"GO:0019048"(modulation by virus of host process) no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Similar to Q69091 - figure legend:Fig. 1 C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/05/07 2014/10/16 - rogid:/KqZN5Vhyc6Qrih7IyHnkN8nsaE9606 intact-crc:9EEE820CB50036EA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UKJ1 uniprotkb:P06436 intact:EBI-965833|ensembl:ENSP00000198536|uniprotkb:Q8NHI1 intact:EBI-1771271 psi-mi:pilra_human(display_long)|uniprotkb:PILRA(gene name)|psi-mi:PILRA(display_short)|uniprotkb:Inhibitory receptor PILR-alpha(gene name synonym)|uniprotkb:Cell surface receptor FDF03(gene name synonym) psi-mi:gb_hhv1f(display_long)|uniprotkb:gB(gene name)|psi-mi:gB(display_short)|uniprotkb:UL27(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Satoh et al. (2008) imex:IM-11914|pubmed:18358807 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10304(hhv1f)|taxid:10304("Human herpesvirus 1 (strain F) (HHV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1771373|imex:IM-11914-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000085514(gene)|ensembl:ENST00000198536(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3WUZ|rcsb pdb:3WV0|rcsb pdb:4NFB|rcsb pdb:5XO2|rcsb pdb:5XOF|reactome:R-HSA-198933|refseq:NP_038467.2|refseq:NP_840056.1|refseq:NP_840057.1 interpro:IPR000234(Herpesvirus Glycoprotein B)|rcsb pdb:1RJY|rcsb pdb:1RJZ|rcsb pdb:1RK0|rcsb pdb:1RK1|rcsb pdb:1T0M|rcsb pdb:1T0N|interpro:IPR035377|interpro:IPR035381|interpro:IPR038631|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane) go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2A|delivery method:P06436 transfection.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/05/07 2014/10/16 rogid:QWSaRQHGXRXAOOMvijnTQztvSpY9606 rogid:TaQY+rnyeBFc5Quy6JBHq1N6JLk10304 intact-crc:3903B63C10AD77C1|rigid:wtmEv/2YZSAQEE+RvoPFBnGCB8E false - sufficient binding region:1-863 - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q15223 intact:EBI-1771356 intact:EBI-1771314|uniprotkb:O75465|uniprotkb:Q2M3D3|uniprotkb:Q9HBE6|uniprotkb:Q9HBW2|ensembl:ENSP00000264025 - psi-mi:nect1_human(display_long)|uniprotkb:NECTIN1(gene name)|psi-mi:NECTIN1(display_short)|uniprotkb:HVEC(gene name synonym)|uniprotkb:Herpes virus entry mediator C(gene name synonym)|uniprotkb:Herpesvirus Ig-like receptor(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 1(gene name synonym)|uniprotkb:PRR1(gene name synonym)|uniprotkb:PVRL1(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 1(gene name synonym) psi-mi:vgld_hhv1f_protein(display_short)|psi-mi:EBI-1771356(display_long) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Satoh et al. (2008) imex:IM-11914|pubmed:18358807 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10304(hhv1f)|taxid:10304("Human herpesvirus 1 (strain F) (HHV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1771381|imex:IM-11914-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002846.3|refseq:NP_976030.1|refseq:NP_976031.1|dip:DIP-40302N|ensembl:ENSG00000110400(gene)|ensembl:ENST00000264025(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0002934"(desmosome organization)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006826"(iron ion transport)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070166"(enamel mineralization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033314|interpro:IPR036179|interpro:IPR041849|interpro:IPR041850|rcsb pdb:3ALP|rcsb pdb:3SKU|rcsb pdb:3U82|rcsb pdb:3U83|rcsb pdb:4FMF|rcsb pdb:4MYW|reactome:R-HSA-418990|reactome:R-HSA-420597 - go:"GO:0019048"(modulation by virus of host process) - no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Similar to Q69091 figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/05/07 2014/10/16 rogid:/KqZN5Vhyc6Qrih7IyHnkN8nsaE9606 - intact-crc:9D3619F607232615 false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)