#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O08715	uniprotkb:Q06986	intact:EBI-7838029|ensembl:ENSMUSP00000018572|ensembl:ENSMUSP00000103536|uniprotkb:B1AR25|uniprotkb:O08714|intact:MINT-4087417|uniprotkb:P97488	intact:EBI-957413|ensembl:ENSMUSP00000067496	psi-mi:akap1_mouse(display_long)|uniprotkb:Akap1(gene name)|psi-mi:Akap1(display_short)|uniprotkb:Akap(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 1(gene name synonym)|uniprotkb:Dual specificity A-kinase-anchoring protein 1(gene name synonym)|uniprotkb:Spermatid A-kinase anchor protein(gene name synonym)	psi-mi:siah2_mouse(display_long)|uniprotkb:Siah2(gene name)|psi-mi:Siah2(display_short)|uniprotkb:Seven in absentia homolog 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Carlucci et al. (2008)	pubmed:18323779|imex:IM-11577|mint:MINT-6543597	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7838023|mint:MINT-6543604|imex:IM-11577-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000018428(gene)|ensembl:ENSMUST00000018572(transcript)|ensembl:ENSMUST00000107903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006915"(apoptotic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR002999(Tudor)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR035437|interpro:IPR036612|mint:O08715|reactome:R-MMU-983231|refseq:NP_001036006.1|refseq:NP_033778.2|mint:MINT-6543618(identity)	refseq:NP_033200.2|ensembl:ENSMUSG00000036432(gene)|ensembl:ENSMUST00000070368(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q06986|reactome:R-MMU-373752|reactome:R-MMU-5689880|reactome:R-MMU-983168|mint:MINT-6543606(identity)	-	comment:mint|function:Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A. Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum. Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 2 and isoform 4 acts as a suppressor of mitochondrial targeting and as an activator of recessive endoplasmic reticulum targeting motif	-	figure legend:F1B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/05/19	2014/10/16	rogid:6nOYmtLWSLBpMwNwgHO75q7WzWc10090	rogid:Rdbim60OD4dIj1xn7RpUoPAvD5010090	intact-crc:1183EDC21C8D5AB4|rigid:NhNWNnByIbUNhNxZxi7tCFqmhj0	false	tag:?-?(MINT-6543666)|binding-associated region:?-?(MINT-6543669)	binding-associated region:112-325(MINT-6543675)|tag:?-?(MINT-6543672)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08715	uniprotkb:Q06986	intact:EBI-7838029|ensembl:ENSMUSP00000018572|ensembl:ENSMUSP00000103536|uniprotkb:B1AR25|uniprotkb:O08714|intact:MINT-4087417|uniprotkb:P97488	intact:EBI-957413|ensembl:ENSMUSP00000067496	psi-mi:akap1_mouse(display_long)|uniprotkb:Akap1(gene name)|psi-mi:Akap1(display_short)|uniprotkb:Akap(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 1(gene name synonym)|uniprotkb:Dual specificity A-kinase-anchoring protein 1(gene name synonym)|uniprotkb:Spermatid A-kinase anchor protein(gene name synonym)	psi-mi:siah2_mouse(display_long)|uniprotkb:Siah2(gene name)|psi-mi:Siah2(display_short)|uniprotkb:Seven in absentia homolog 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Carlucci et al. (2008)	pubmed:18323779|imex:IM-11577|mint:MINT-6543597	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7838095|mint:MINT-6543696|imex:IM-11577-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000018428(gene)|ensembl:ENSMUST00000018572(transcript)|ensembl:ENSMUST00000107903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006915"(apoptotic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR002999(Tudor)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR035437|interpro:IPR036612|mint:O08715|reactome:R-MMU-983231|refseq:NP_001036006.1|refseq:NP_033778.2|mint:MINT-6543704(identity)	refseq:NP_033200.2|ensembl:ENSMUSG00000036432(gene)|ensembl:ENSMUST00000070368(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q06986|reactome:R-MMU-373752|reactome:R-MMU-5689880|reactome:R-MMU-983168|mint:MINT-6543698(identity)	-	comment:mint|function:Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A. Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum. Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 2 and isoform 4 acts as a suppressor of mitochondrial targeting and as an activator of recessive endoplasmic reticulum targeting motif	-	figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/19	2014/10/16	rogid:6nOYmtLWSLBpMwNwgHO75q7WzWc10090	rogid:Rdbim60OD4dIj1xn7RpUoPAvD5010090	intact-crc:32C5C5913FBF38D6|rigid:NhNWNnByIbUNhNxZxi7tCFqmhj0	false	maltose binding protein tag:?-?(MINT-6543707)	glutathione s tranferase tag:?-?(MINT-6543701)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O08715	uniprotkb:Q06986	intact:EBI-7838029|ensembl:ENSMUSP00000018572|ensembl:ENSMUSP00000103536|uniprotkb:B1AR25|uniprotkb:O08714|intact:MINT-4087417|uniprotkb:P97488	intact:EBI-957413|ensembl:ENSMUSP00000067496	psi-mi:akap1_mouse(display_long)|uniprotkb:Akap1(gene name)|psi-mi:Akap1(display_short)|uniprotkb:Akap(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 1(gene name synonym)|uniprotkb:Dual specificity A-kinase-anchoring protein 1(gene name synonym)|uniprotkb:Spermatid A-kinase anchor protein(gene name synonym)	psi-mi:siah2_mouse(display_long)|uniprotkb:Siah2(gene name)|psi-mi:Siah2(display_short)|uniprotkb:Seven in absentia homolog 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Carlucci et al. (2008)	pubmed:18323779|imex:IM-11577|mint:MINT-6543597	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7838130|mint:MINT-6543719|imex:IM-11577-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000018428(gene)|ensembl:ENSMUST00000018572(transcript)|ensembl:ENSMUST00000107903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006915"(apoptotic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR002999(Tudor)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR035437|interpro:IPR036612|mint:O08715|reactome:R-MMU-983231|refseq:NP_001036006.1|refseq:NP_033778.2|mint:MINT-6543725(identity)	refseq:NP_033200.2|ensembl:ENSMUSG00000036432(gene)|ensembl:ENSMUST00000070368(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q06986|reactome:R-MMU-373752|reactome:R-MMU-5689880|reactome:R-MMU-983168|mint:MINT-6543721(identity)	-	comment:mint|function:Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A. Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum. Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 2 and isoform 4 acts as a suppressor of mitochondrial targeting and as an activator of recessive endoplasmic reticulum targeting motif	-	figure legend:F1D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/19	2014/10/16	rogid:6nOYmtLWSLBpMwNwgHO75q7WzWc10090	rogid:Rdbim60OD4dIj1xn7RpUoPAvD5010090	intact-crc:C077665432496D09|rigid:NhNWNnByIbUNhNxZxi7tCFqmhj0	false	-	ha tag:?-?(MINT-6543722)	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q06986	uniprotkb:O08715	intact:EBI-957413|ensembl:ENSMUSP00000067496	intact:EBI-7838029|ensembl:ENSMUSP00000018572|ensembl:ENSMUSP00000103536|uniprotkb:B1AR25|uniprotkb:O08714|intact:MINT-4087417|uniprotkb:P97488	psi-mi:siah2_mouse(display_long)|uniprotkb:Siah2(gene name)|psi-mi:Siah2(display_short)|uniprotkb:Seven in absentia homolog 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH2(gene name synonym)	psi-mi:akap1_mouse(display_long)|uniprotkb:Akap1(gene name)|psi-mi:Akap1(display_short)|uniprotkb:Akap(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 1(gene name synonym)|uniprotkb:Dual specificity A-kinase-anchoring protein 1(gene name synonym)|uniprotkb:Spermatid A-kinase anchor protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Carlucci et al. (2008)	pubmed:18323779|imex:IM-11577|mint:MINT-6543597	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7838209|mint:MINT-6543734|imex:IM-11577-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033200.2|ensembl:ENSMUSG00000036432(gene)|ensembl:ENSMUST00000070368(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q06986|reactome:R-MMU-373752|reactome:R-MMU-5689880|reactome:R-MMU-983168|mint:MINT-6543738(identity)	ensembl:ENSMUSG00000018428(gene)|ensembl:ENSMUST00000018572(transcript)|ensembl:ENSMUST00000107903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006915"(apoptotic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR002999(Tudor)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR035437|interpro:IPR036612|mint:O08715|reactome:R-MMU-983231|refseq:NP_001036006.1|refseq:NP_033778.2|mint:MINT-6543736(identity)	-	-	comment:mint|function:Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A. Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum. Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 2 and isoform 4 acts as a suppressor of mitochondrial targeting and as an activator of recessive endoplasmic reticulum targeting motif	figure legend:F1E|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/05/19	2014/10/16	rogid:Rdbim60OD4dIj1xn7RpUoPAvD5010090	rogid:6nOYmtLWSLBpMwNwgHO75q7WzWc10090	intact-crc:5925800AE005F907|rigid:o9E4K1tjQYnoZGbj6PHChMdRbSI	false	flag tag:?-?(MINT-6543739)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q06986	uniprotkb:Q92667	intact:EBI-957413|ensembl:ENSMUSP00000067496	intact:EBI-2119593|uniprotkb:Q13320|uniprotkb:Q9BW14|uniprotkb:A8K8Q1|uniprotkb:D3DTZ0|ensembl:ENSP00000337736|ensembl:ENSP00000443139|ensembl:ENSP00000459895|ensembl:ENSP00000459968|ensembl:ENSP00000478212	psi-mi:siah2_mouse(display_long)|uniprotkb:Siah2(gene name)|psi-mi:Siah2(display_short)|uniprotkb:Seven in absentia homolog 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH2(gene name synonym)	psi-mi:akap1_human(display_long)|uniprotkb:AKAP1(gene name)|psi-mi:AKAP1(display_short)|uniprotkb:AKAP149(gene name synonym)|uniprotkb:PRKA1(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 1(gene name synonym)|uniprotkb:A-kinase anchor protein 149 kDa(gene name synonym)|uniprotkb:Dual specificity A-kinase-anchoring protein 1(gene name synonym)|uniprotkb:Spermatid A-kinase anchor protein 84(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Carlucci et al. (2008)	pubmed:18323779|imex:IM-11577|mint:MINT-6543597	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7838209|mint:MINT-6543734|imex:IM-11577-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033200.2|ensembl:ENSMUSG00000036432(gene)|ensembl:ENSMUST00000070368(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q06986|reactome:R-MMU-373752|reactome:R-MMU-5689880|reactome:R-MMU-983168|mint:MINT-6543738(identity)	refseq:XP_016880678.1|refseq:XP_016880679.1|refseq:XP_016880680.1|refseq:NP_001229831.1|refseq:NP_001229832.1|refseq:NP_003479.1|refseq:XP_005257764.1|refseq:XP_005257766.1|ensembl:ENSG00000121057(gene)|ensembl:ENST00000337714(transcript)|ensembl:ENST00000539273(transcript)|ensembl:ENST00000571629(transcript)|ensembl:ENST00000572557(transcript)|ensembl:ENST00000621116(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR002999(Tudor)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR035437|interpro:IPR036612|mint:Q92667|reactome:R-HSA-8949215|reactome:R-HSA-983231|mint:MINT-6543747(identity)	-	-	-	figure legend:F1E|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/05/19	2014/10/16	rogid:Rdbim60OD4dIj1xn7RpUoPAvD5010090	rogid:8HzwuoBdBWw+LZKg6WpYxMKnfYE9606	intact-crc:5925800AE005F907|rigid:o9E4K1tjQYnoZGbj6PHChMdRbSI	false	flag tag:?-?(MINT-6543739)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q06986	uniprotkb:O08715	intact:EBI-957413|ensembl:ENSMUSP00000067496	intact:EBI-7838029|ensembl:ENSMUSP00000018572|ensembl:ENSMUSP00000103536|uniprotkb:B1AR25|uniprotkb:O08714|intact:MINT-4087417|uniprotkb:P97488	psi-mi:siah2_mouse(display_long)|uniprotkb:Siah2(gene name)|psi-mi:Siah2(display_short)|uniprotkb:Seven in absentia homolog 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH2(gene name synonym)	psi-mi:akap1_mouse(display_long)|uniprotkb:Akap1(gene name)|psi-mi:Akap1(display_short)|uniprotkb:Akap(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 1(gene name synonym)|uniprotkb:Dual specificity A-kinase-anchoring protein 1(gene name synonym)|uniprotkb:Spermatid A-kinase anchor protein(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Carlucci et al. (2008)	pubmed:18323779|imex:IM-11577|mint:MINT-6543597	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7838238|mint:MINT-6543750|imex:IM-11577-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033200.2|ensembl:ENSMUSG00000036432(gene)|ensembl:ENSMUST00000070368(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q06986|reactome:R-MMU-373752|reactome:R-MMU-5689880|reactome:R-MMU-983168|mint:MINT-6543754(identity)	ensembl:ENSMUSG00000018428(gene)|ensembl:ENSMUST00000018572(transcript)|ensembl:ENSMUST00000107903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006915"(apoptotic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR002999(Tudor)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR035437|interpro:IPR036612|mint:O08715|reactome:R-MMU-983231|refseq:NP_001036006.1|refseq:NP_033778.2|mint:MINT-6543758(identity)	go:"GO:0005739"(mitochondrion)	-	comment:mint|function:Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A. Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum. Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 2 and isoform 4 acts as a suppressor of mitochondrial targeting and as an activator of recessive endoplasmic reticulum targeting motif	figure legend:F1F|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/05/19	2014/10/16	rogid:Rdbim60OD4dIj1xn7RpUoPAvD5010090	rogid:6nOYmtLWSLBpMwNwgHO75q7WzWc10090	intact-crc:C759F039D965A985|rigid:z84mqW/pb5w49bdHpBdAz1I3cxY	false	flag tag:?-?(MINT-6543755)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q06986	uniprotkb:P21796	intact:EBI-957413|ensembl:ENSMUSP00000067496	intact:EBI-354158|uniprotkb:Q5FVE7|uniprotkb:Q9UIQ5|uniprotkb:Q9UPL0|uniprotkb:B3KVK4|uniprotkb:D3DQ93|ensembl:ENSP00000265333|ensembl:ENSP00000378484|ensembl:ENSP00000378487	psi-mi:siah2_mouse(display_long)|uniprotkb:Siah2(gene name)|psi-mi:Siah2(display_short)|uniprotkb:Seven in absentia homolog 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH2(gene name synonym)	psi-mi:vdac1_human(display_long)|uniprotkb:VDAC1(gene name)|psi-mi:VDAC1(display_short)|uniprotkb:VDAC(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym)|uniprotkb:Porin 31HL(gene name synonym)|uniprotkb:Porin 31HM(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Carlucci et al. (2008)	pubmed:18323779|imex:IM-11577|mint:MINT-6543597	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7838238|mint:MINT-6543750|imex:IM-11577-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033200.2|ensembl:ENSMUSG00000036432(gene)|ensembl:ENSMUST00000070368(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q06986|reactome:R-MMU-373752|reactome:R-MMU-5689880|reactome:R-MMU-983168|mint:MINT-6543754(identity)	refseq:NP_003365.1|refseq:XP_005272132.1|refseq:XP_016865310.1|refseq:XP_016865311.1|refseq:XP_016865312.1|dip:DIP-32862N|ensembl:ENSG00000213585(gene)|ensembl:ENST00000265333(transcript)|ensembl:ENST00000395044(transcript)|ensembl:ENST00000395047(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:P21796|rcsb pdb:2JK4|rcsb pdb:2K4T|rcsb pdb:5JDP|rcsb pdb:5XDN|rcsb pdb:5XDO|rcsb pdb:6G6U|rcsb pdb:6G73|rcsb pdb:6TIQ|rcsb pdb:6TIR|reactome:R-HSA-1268020|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-70268|reactome:R-HSA-8949215|mint:MINT-6543768(identity)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:F1F|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/05/19	2014/10/16	rogid:Rdbim60OD4dIj1xn7RpUoPAvD5010090	rogid:8Fqe6Ga3NmwwuICa4L45ga2i1nk9606	intact-crc:C759F039D965A985|rigid:z84mqW/pb5w49bdHpBdAz1I3cxY	false	flag tag:?-?(MINT-6543755)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q06986	uniprotkb:Q92667	intact:EBI-957413|ensembl:ENSMUSP00000067496	intact:EBI-2119593|uniprotkb:Q13320|uniprotkb:Q9BW14|uniprotkb:A8K8Q1|uniprotkb:D3DTZ0|ensembl:ENSP00000337736|ensembl:ENSP00000443139|ensembl:ENSP00000459895|ensembl:ENSP00000459968|ensembl:ENSP00000478212	psi-mi:siah2_mouse(display_long)|uniprotkb:Siah2(gene name)|psi-mi:Siah2(display_short)|uniprotkb:Seven in absentia homolog 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH2(gene name synonym)	psi-mi:akap1_human(display_long)|uniprotkb:AKAP1(gene name)|psi-mi:AKAP1(display_short)|uniprotkb:AKAP149(gene name synonym)|uniprotkb:PRKA1(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 1(gene name synonym)|uniprotkb:A-kinase anchor protein 149 kDa(gene name synonym)|uniprotkb:Dual specificity A-kinase-anchoring protein 1(gene name synonym)|uniprotkb:Spermatid A-kinase anchor protein 84(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Carlucci et al. (2008)	pubmed:18323779|imex:IM-11577|mint:MINT-6543597	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7838238|mint:MINT-6543750|imex:IM-11577-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033200.2|ensembl:ENSMUSG00000036432(gene)|ensembl:ENSMUST00000070368(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q06986|reactome:R-MMU-373752|reactome:R-MMU-5689880|reactome:R-MMU-983168|mint:MINT-6543754(identity)	refseq:XP_016880678.1|refseq:XP_016880679.1|refseq:XP_016880680.1|refseq:NP_001229831.1|refseq:NP_001229832.1|refseq:NP_003479.1|refseq:XP_005257764.1|refseq:XP_005257766.1|ensembl:ENSG00000121057(gene)|ensembl:ENST00000337714(transcript)|ensembl:ENST00000539273(transcript)|ensembl:ENST00000571629(transcript)|ensembl:ENST00000572557(transcript)|ensembl:ENST00000621116(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR002999(Tudor)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR035437|interpro:IPR036612|mint:Q92667|reactome:R-HSA-8949215|reactome:R-HSA-983231|mint:MINT-6543752(identity)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:F1F|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/05/19	2014/10/16	rogid:Rdbim60OD4dIj1xn7RpUoPAvD5010090	rogid:8HzwuoBdBWw+LZKg6WpYxMKnfYE9606	intact-crc:C759F039D965A985|rigid:z84mqW/pb5w49bdHpBdAz1I3cxY	false	flag tag:?-?(MINT-6543755)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O08715	uniprotkb:Q06986	intact:EBI-7838029|ensembl:ENSMUSP00000018572|ensembl:ENSMUSP00000103536|uniprotkb:B1AR25|uniprotkb:O08714|intact:MINT-4087417|uniprotkb:P97488	intact:EBI-957413|ensembl:ENSMUSP00000067496	psi-mi:akap1_mouse(display_long)|uniprotkb:Akap1(gene name)|psi-mi:Akap1(display_short)|uniprotkb:Akap(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 1(gene name synonym)|uniprotkb:Dual specificity A-kinase-anchoring protein 1(gene name synonym)|uniprotkb:Spermatid A-kinase anchor protein(gene name synonym)	psi-mi:siah2_mouse(display_long)|uniprotkb:Siah2(gene name)|psi-mi:Siah2(display_short)|uniprotkb:Seven in absentia homolog 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH2(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Carlucci et al. (2008)	pubmed:18323779|imex:IM-11577|mint:MINT-6543597	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7838272|mint:MINT-6543771|imex:IM-11577-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000018428(gene)|ensembl:ENSMUST00000018572(transcript)|ensembl:ENSMUST00000107903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006915"(apoptotic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR002999(Tudor)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR035437|interpro:IPR036612|mint:O08715|reactome:R-MMU-983231|refseq:NP_001036006.1|refseq:NP_033778.2|mint:MINT-6543773(identity)	refseq:NP_033200.2|ensembl:ENSMUSG00000036432(gene)|ensembl:ENSMUST00000070368(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q06986|reactome:R-MMU-373752|reactome:R-MMU-5689880|reactome:R-MMU-983168|mint:MINT-6543775(identity)	go:"GO:0005739"(mitochondrion)	comment:mint|function:Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A. Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum. Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 2 and isoform 4 acts as a suppressor of mitochondrial targeting and as an activator of recessive endoplasmic reticulum targeting motif	-	figure legend:F1G|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2008/05/19	2014/10/16	rogid:6nOYmtLWSLBpMwNwgHO75q7WzWc10090	rogid:Rdbim60OD4dIj1xn7RpUoPAvD5010090	intact-crc:EFCE032C4D0BBDB8|rigid:NhNWNnByIbUNhNxZxi7tCFqmhj0	false	-	ha tag:?-?(MINT-6543776)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:O08715	uniprotkb:P62991	intact:EBI-7838029|ensembl:ENSMUSP00000018572|ensembl:ENSMUSP00000103536|uniprotkb:B1AR25|uniprotkb:O08714|intact:MINT-4087417|uniprotkb:P97488	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	psi-mi:akap1_mouse(display_long)|uniprotkb:Akap1(gene name)|psi-mi:Akap1(display_short)|uniprotkb:Akap(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 1(gene name synonym)|uniprotkb:Dual specificity A-kinase-anchoring protein 1(gene name synonym)|uniprotkb:Spermatid A-kinase anchor protein(gene name synonym)	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Carlucci et al. (2008)	pubmed:18323779|imex:IM-11577|mint:MINT-6543597	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7838299|mint:MINT-6543786|imex:IM-11577-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000018428(gene)|ensembl:ENSMUST00000018572(transcript)|ensembl:ENSMUST00000107903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006915"(apoptotic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR002999(Tudor)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR035437|interpro:IPR036612|mint:O08715|reactome:R-MMU-983231|refseq:NP_001036006.1|refseq:NP_033778.2|mint:MINT-6543794(identity)	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K|mint:MINT-6543790(identity)	-	comment:mint|function:Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A. Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum. Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 2 and isoform 4 acts as a suppressor of mitochondrial targeting and as an activator of recessive endoplasmic reticulum targeting motif	-	figure legend:F4A F4B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/05/19	2014/10/16	rogid:6nOYmtLWSLBpMwNwgHO75q7WzWc10090	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	intact-crc:89A29BAF105D1157|rigid:K0np2BXHegpH/tCoK7gz7YEwdEk	false	-	ha tag:?-?(MINT-6543791)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)