#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q62839 uniprotkb:Q62931 intact:EBI-618335|uniprotkb:F1LSS0 intact:EBI-7837133|ensembl:ENSRNOP00000068434|intact:MINT-4569995|uniprotkb:A0JN01 psi-mi:goga2_rat(display_long)|uniprotkb:Golga2(gene name)|psi-mi:Golga2(display_short)|uniprotkb:130 kDa cis-Golgi matrix protein(gene name synonym) psi-mi:gosr1_rat(display_long)|uniprotkb:Gosr1(gene name)|psi-mi:Gosr1(display_short)|uniprotkb:Gs28(gene name synonym)|uniprotkb:28 kDa Golgi SNARE protein(gene name synonym)|uniprotkb:28 kDa cis-Golgi SNARE p28(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Bartz et al. (2008) pubmed:18323777|imex:IM-11583|mint:MINT-6544792 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7837183|mint:MINT-6544812|imex:IM-11583-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR043937|interpro:IPR043976|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005874"(microtubule)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007030"(Golgi organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051225"(spindle assembly)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051645"(Golgi localization)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0090307"(mitotic spindle assembly)|reactome:R-RNO-162658|reactome:R-RNO-204005|go:"GO:0007098"(centrosome cycle)|reactome:R-RNO-6807878|reactome:R-RNO-9013148|reactome:R-RNO-9013405|rgd:620282|refseq:NP_072118.2|refseq:XP_006234060.1|interpro:IPR024858|mint:Q62839|mint:MINT-6544815(identity) ensembl:ENSRNOG00000003971(gene)|ensembl:ENSRNOT00000077063(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048209"(regulation of vesicle targeting, to, from or within Golgi)|interpro:IPR023601|mint:Q62931|reactome:R-RNO-6807878|reactome:R-RNO-6811438|rgd:71093|refseq:NP_446036.1|mint:MINT-6544816(identity) go:"GO:0000139"(Golgi membrane) - comment:mint|function:Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport figure legend:F1A F1B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver) - 2008/05/22 2015/11/10 rogid:zW0U11na/96FACXJccRSnFPMte010116 rogid:A1I17p7sB3hZGW3y7AjPQI0TPSg10116 intact-crc:60F10FA6AEEBAA4F|rigid:S1yCJLLY9EDKM8CfFRFcrvGFSzk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q62839 uniprotkb:P28494 intact:EBI-618335|uniprotkb:F1LSS0 intact:EBI-7836162|uniprotkb:G3V7Y9|ensembl:ENSRNOP00000020767|intact:MINT-4574652 psi-mi:goga2_rat(display_long)|uniprotkb:Golga2(gene name)|psi-mi:Golga2(display_short)|uniprotkb:130 kDa cis-Golgi matrix protein(gene name synonym) psi-mi:ma2a1_rat(display_long)|uniprotkb:Man2a1(gene name)|psi-mi:Man2a1(display_short)|uniprotkb:Mana2(gene name synonym)|uniprotkb:Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase(gene name synonym)|uniprotkb:Golgi alpha-mannosidase II(gene name synonym)|uniprotkb:Mannosidase alpha class 2A member 1(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Bartz et al. (2008) pubmed:18323777|imex:IM-11583|mint:MINT-6544792 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7837183|mint:MINT-6544812|imex:IM-11583-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR043937|interpro:IPR043976|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005874"(microtubule)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007030"(Golgi organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051225"(spindle assembly)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051645"(Golgi localization)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0090307"(mitotic spindle assembly)|reactome:R-RNO-162658|reactome:R-RNO-204005|go:"GO:0007098"(centrosome cycle)|reactome:R-RNO-6807878|reactome:R-RNO-9013148|reactome:R-RNO-9013405|rgd:620282|refseq:NP_072118.2|refseq:XP_006234060.1|interpro:IPR024858|mint:Q62839|mint:MINT-6544815(identity) refseq:NP_037111.2|ensembl:ENSRNOG00000015439(gene)|ensembl:ENSRNOT00000020767(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0004559"(alpha-mannosidase activity)|go:"GO:0004572"(mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0006013"(mannose metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006491"(N-glycan processing)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007033"(vacuole organization)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015923"(mannosidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016799"(hydrolase activity, hydrolyzing N-glycosyl compounds)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|interpro:IPR000602(Glycoside hydrolase, family 38, core)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR011330(Glycoside hydrolase/deacetylase, beta/alpha-barrel)|interpro:IPR011682(Glycosyl hydrolases 38, C-terminal)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR015341(Glycoside hydrolase, family 38, central region)|interpro:IPR027291|interpro:IPR028995|interpro:IPR037094|mint:P28494|reactome:R-RNO-975578|rgd:3038|mint:MINT-6544817(identity) go:"GO:0000139"(Golgi membrane) - comment:"fragmentation type: fragment"|comment:mint|function:Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway figure legend:F1A F1B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver) - 2008/05/22 2015/11/10 rogid:zW0U11na/96FACXJccRSnFPMte010116 rogid:5K/TG9G4mrhfcqeTc9JcjW6yBSQ10116 intact-crc:60F10FA6AEEBAA4F|rigid:S1yCJLLY9EDKM8CfFRFcrvGFSzk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q62839 uniprotkb:Q9WTZ3 intact:EBI-618335|uniprotkb:F1LSS0 intact:EBI-7837156|ensembl:ENSRNOP00000020838|ensembl:ENSRNOP00000071317|intact:MINT-6544799|uniprotkb:G3V7Z2 psi-mi:goga2_rat(display_long)|uniprotkb:Golga2(gene name)|psi-mi:Golga2(display_short)|uniprotkb:130 kDa cis-Golgi matrix protein(gene name synonym) psi-mi:mbtp1_rat(display_long)|uniprotkb:Mbtps1(gene name)|psi-mi:Mbtps1(display_short)|uniprotkb:S1p(gene name synonym)|uniprotkb:Ski1(gene name synonym)|uniprotkb:Subtilisin/kexin isozyme 1(gene name synonym)|uniprotkb:Endopeptidase S1P(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Bartz et al. (2008) pubmed:18323777|imex:IM-11583|mint:MINT-6544792 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7837183|mint:MINT-6544812|imex:IM-11583-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR043937|interpro:IPR043976|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005874"(microtubule)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007030"(Golgi organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051225"(spindle assembly)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051645"(Golgi localization)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0090307"(mitotic spindle assembly)|reactome:R-RNO-162658|reactome:R-RNO-204005|go:"GO:0007098"(centrosome cycle)|reactome:R-RNO-6807878|reactome:R-RNO-9013148|reactome:R-RNO-9013405|rgd:620282|refseq:NP_072118.2|refseq:XP_006234060.1|interpro:IPR024858|mint:Q62839|mint:MINT-6544815(identity) ensembl:ENSRNOG00000015173(gene)|ensembl:ENSRNOT00000020838(transcript)|ensembl:ENSRNOT00000087886(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007040"(lysosome organization)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0060627"(regulation of vesicle-mediated transport)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR022398|interpro:IPR023828|interpro:IPR034185|interpro:IPR036852|mint:Q9WTZ3|reactome:R-RNO-1655829|reactome:R-RNO-381033|reactome:R-RNO-381426|reactome:R-RNO-8874211|reactome:R-RNO-8957275|refseq:NP_446021.1|rgd:70935|refseq:XP_006255785.1|mint:MINT-6544814(identity) go:"GO:0000139"(Golgi membrane) - comment:mint|function:"Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu" figure legend:F1A F1B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver) - 2008/05/22 2015/11/10 rogid:zW0U11na/96FACXJccRSnFPMte010116 rogid:50SW1Y4Jza1aS+owLnqpRinVFI410116 intact-crc:60F10FA6AEEBAA4F|rigid:S1yCJLLY9EDKM8CfFRFcrvGFSzk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9WTZ3 uniprotkb:Q62839 intact:EBI-7837156|ensembl:ENSRNOP00000020838|ensembl:ENSRNOP00000071317|intact:MINT-6544799|uniprotkb:G3V7Z2 intact:EBI-618335|uniprotkb:F1LSS0 psi-mi:mbtp1_rat(display_long)|uniprotkb:Mbtps1(gene name)|psi-mi:Mbtps1(display_short)|uniprotkb:S1p(gene name synonym)|uniprotkb:Ski1(gene name synonym)|uniprotkb:Subtilisin/kexin isozyme 1(gene name synonym)|uniprotkb:Endopeptidase S1P(gene name synonym) psi-mi:goga2_rat(display_long)|uniprotkb:Golga2(gene name)|psi-mi:Golga2(display_short)|uniprotkb:130 kDa cis-Golgi matrix protein(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Bartz et al. (2008) pubmed:18323777|imex:IM-11583|mint:MINT-6544792 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7837230|mint:MINT-6544829|imex:IM-11583-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000015173(gene)|ensembl:ENSRNOT00000020838(transcript)|ensembl:ENSRNOT00000087886(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007040"(lysosome organization)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0060627"(regulation of vesicle-mediated transport)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR022398|interpro:IPR023828|interpro:IPR034185|interpro:IPR036852|mint:Q9WTZ3|reactome:R-RNO-1655829|reactome:R-RNO-381033|reactome:R-RNO-381426|reactome:R-RNO-8874211|reactome:R-RNO-8957275|refseq:NP_446021.1|rgd:70935|refseq:XP_006255785.1|mint:MINT-6544838(identity) interpro:IPR043937|interpro:IPR043976|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005874"(microtubule)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007030"(Golgi organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051225"(spindle assembly)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051645"(Golgi localization)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0090307"(mitotic spindle assembly)|reactome:R-RNO-162658|reactome:R-RNO-204005|go:"GO:0007098"(centrosome cycle)|reactome:R-RNO-6807878|reactome:R-RNO-9013148|reactome:R-RNO-9013405|rgd:620282|refseq:NP_072118.2|refseq:XP_006234060.1|interpro:IPR024858|mint:Q62839|mint:MINT-6544836(identity) go:"GO:0005794"(Golgi apparatus) comment:mint|function:"Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu" - figure legend:F1C F2|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-nrk)|taxid:10116(Rattus norvegicus kidney fibroblast cell line NRK) - 2008/05/22 2015/11/10 rogid:50SW1Y4Jza1aS+owLnqpRinVFI410116 rogid:zW0U11na/96FACXJccRSnFPMte010116 intact-crc:2306DE3CBA2698E0|rigid:NoIHVwvaL/za4LrU/fG86PrExGA false - - - - psi-mi:"MI:0709"(polyclonal antibody immunostaining) psi-mi:"MI:0708"(monoclonal antibody immunostaining)