#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02340	uniprotkb:P62991	intact:EBI-474016|uniprotkb:Q9QUP3|ensembl:ENSMUSP00000104298	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	psi-mi:p53_mouse(display_long)|uniprotkb:Tp53(gene name)|psi-mi:Tp53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Trp53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833157|mint:MINT-6540751|imex:IM-11563-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000059552(gene)|ensembl:ENSMUST00000108658(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903205"(regulation of hydrogen peroxide-induced cell death)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|mint:P02340|rcsb pdb:1HU8|rcsb pdb:2GEQ|rcsb pdb:2IOI|rcsb pdb:2IOM|rcsb pdb:2IOO|rcsb pdb:2P52|rcsb pdb:3EXJ|rcsb pdb:3EXL|reactome:R-MMU-2559580|reactome:R-MMU-2559584|reactome:R-MMU-2559585|reactome:R-MMU-2559586|reactome:R-MMU-349425|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-5693565|reactome:R-MMU-6804754|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-6804758|reactome:R-MMU-6804759|reactome:R-MMU-6804760|reactome:R-MMU-6811555|reactome:R-MMU-69473|reactome:R-MMU-69481|reactome:R-MMU-69541|reactome:R-MMU-69895|reactome:R-MMU-8852276|reactome:R-MMU-8941855|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007569"(cell aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009411"(response to UV)|go:"GO:0009651"(response to salt stress)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010038"(response to metal ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033552"(response to vitamin B3)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043200"(response to amino acid)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045471"(response to ethanol)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051276"(chromosome organization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070243"(regulation of thymocyte apoptotic process)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0034644"(cellular response to UV)|refseq:NP_001120705.1|refseq:NP_035770.2|refseq:XP_006533220.1|dip:DIP-369N|mint:MINT-6540753(identity)	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K|mint:MINT-6540754(identity)	-	-	-	figure legend:F3B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lncap)|taxid:10090(Mus musculus)	-	2008/05/07	2018/10/11	rogid:ZU1071LBVm95uqzi6RBNluw8wFo10090	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	intact-crc:672DF0F0867B9E3A|rigid:p46oNn8jQWe9t809LSYxrb2bFuI	false	-	ha tag:?-?(MINT-6540759)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P62991	uniprotkb:P02340	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	intact:EBI-474016|uniprotkb:Q9QUP3|ensembl:ENSMUSP00000104298	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:p53_mouse(display_long)|uniprotkb:Tp53(gene name)|psi-mi:Tp53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Trp53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833173|mint:MINT-6540765|imex:IM-11563-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K|mint:MINT-6540769(identity)	ensembl:ENSMUSG00000059552(gene)|ensembl:ENSMUST00000108658(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903205"(regulation of hydrogen peroxide-induced cell death)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|mint:P02340|rcsb pdb:1HU8|rcsb pdb:2GEQ|rcsb pdb:2IOI|rcsb pdb:2IOM|rcsb pdb:2IOO|rcsb pdb:2P52|rcsb pdb:3EXJ|rcsb pdb:3EXL|reactome:R-MMU-2559580|reactome:R-MMU-2559584|reactome:R-MMU-2559585|reactome:R-MMU-2559586|reactome:R-MMU-349425|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-5693565|reactome:R-MMU-6804754|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-6804758|reactome:R-MMU-6804759|reactome:R-MMU-6804760|reactome:R-MMU-6811555|reactome:R-MMU-69473|reactome:R-MMU-69481|reactome:R-MMU-69541|reactome:R-MMU-69895|reactome:R-MMU-8852276|reactome:R-MMU-8941855|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007569"(cell aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009411"(response to UV)|go:"GO:0009651"(response to salt stress)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010038"(response to metal ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033552"(response to vitamin B3)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043200"(response to amino acid)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045471"(response to ethanol)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051276"(chromosome organization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070243"(regulation of thymocyte apoptotic process)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0034644"(cellular response to UV)|refseq:NP_001120705.1|refseq:NP_035770.2|refseq:XP_006533220.1|dip:DIP-369N|mint:MINT-6540767(identity)	-	-	-	figure legend:F3C|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lncap)|taxid:10090(Mus musculus)	-	2008/05/07	2018/10/11	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	rogid:ZU1071LBVm95uqzi6RBNluw8wFo10090	intact-crc:8371B455E4B0B933|rigid:p46oNn8jQWe9t809LSYxrb2bFuI	false	ha tag:?-?(MINT-6540770)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q00987	uniprotkb:P61289	intact:EBI-389668|intact:EBI-28980679|ensembl:ENSP00000444430|uniprotkb:A6NL51|uniprotkb:Q13226|uniprotkb:Q13297|uniprotkb:Q13298|uniprotkb:Q13299|uniprotkb:Q13300|uniprotkb:Q13301|uniprotkb:Q53XW0|uniprotkb:Q71TW9|uniprotkb:Q8WYJ1|uniprotkb:Q8WYJ2|uniprotkb:Q9UGI3|uniprotkb:Q9UMT8|uniprotkb:A8K2S6	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	psi-mi:mdm2_human(display_long)|uniprotkb:MDM2(gene name)|psi-mi:MDM2(display_short)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833215|mint:MINT-6540796|imex:IM-11563-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135679(gene)|ensembl:ENST00000539479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000258149|ensembl:ENSP00000258149|ensembl:ENST00000299252|ensembl:ENSP00000299252|ensembl:ENST00000360430|ensembl:ENSP00000353611|ensembl:ENST00000393413|ensembl:ENSP00000377065|ensembl:ENSP00000444430|refseq:NP_001138811.1|refseq:NP_001265391.1|refseq:NP_002383.2|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036369"(transcription factor catabolic process)|refseq:XP_005268929.1|refseq:XP_006719462.1|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|interpro:IPR044080|mint:Q00987|rcsb pdb:1RV1|rcsb pdb:1T4E|rcsb pdb:1T4F|rcsb pdb:1YCR|rcsb pdb:1Z1M|rcsb pdb:2AXI|rcsb pdb:2C6A|rcsb pdb:2C6B|rcsb pdb:2F1Y|rcsb pdb:2FOP|rcsb pdb:2GV2|rcsb pdb:2HDP|rcsb pdb:2LZG|rcsb pdb:2M86|rcsb pdb:2MPS|rcsb pdb:2RUH|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:3EQS|rcsb pdb:3G03|rcsb pdb:3IUX|rcsb pdb:3IWY|rcsb pdb:3JZK|rcsb pdb:3JZR|rcsb pdb:3JZS|rcsb pdb:3LBK|rcsb pdb:3LBL|rcsb pdb:3LNJ|rcsb pdb:3LNZ|rcsb pdb:3MQS|rcsb pdb:3TJ2|rcsb pdb:3TPX|rcsb pdb:3TU1|rcsb pdb:3V3B|rcsb pdb:3VBG|rcsb pdb:3VZV|rcsb pdb:3W69|rcsb pdb:4DIJ|rcsb pdb:4ERE|rcsb pdb:4ERF|rcsb pdb:4HBM|rcsb pdb:4HFZ|rcsb pdb:4HG7|rcsb pdb:4JV7|rcsb pdb:4JV9|rcsb pdb:4JVE|rcsb pdb:4JVR|rcsb pdb:4JWR|rcsb pdb:4MDN|rcsb pdb:4MDQ|rcsb pdb:4OAS|rcsb pdb:4OBA|rcsb pdb:4OCC|rcsb pdb:4ODE|rcsb pdb:4ODF|rcsb pdb:4OGN|rcsb pdb:4OGT|rcsb pdb:4OGV|rcsb pdb:4OQ3|rcsb pdb:4QO4|rcsb pdb:4QOC|rcsb pdb:4UD7|rcsb pdb:4UE1|rcsb pdb:4XXB|rcsb pdb:4ZFI|rcsb pdb:4ZGK|rcsb pdb:4ZYC|rcsb pdb:4ZYF|rcsb pdb:4ZYI|rcsb pdb:5AFG|rcsb pdb:5HMH|rcsb pdb:5HMI|rcsb pdb:5HMK|rcsb pdb:5J7F|rcsb pdb:5J7G|rcsb pdb:5LAV|rcsb pdb:5LAW|rcsb pdb:5C5A|rcsb pdb:5LAY|rcsb pdb:5LAZ|rcsb pdb:5LN2|rcsb pdb:5MNJ|rcsb pdb:5OAI|rcsb pdb:5OC8|rcsb pdb:5SWK|rcsb pdb:5TRF|rcsb pdb:5UMM|rcsb pdb:5VK0|rcsb pdb:5WTS|rcsb pdb:5XXK|rcsb pdb:5Z02|rcsb pdb:5ZXF|rcsb pdb:6AAW|rcsb pdb:6GGN|rcsb pdb:6H22|rcsb pdb:6HFA|rcsb pdb:6I29|rcsb pdb:6I3S|rcsb pdb:6IM9|rcsb pdb:6KZU|rcsb pdb:6Q96|rcsb pdb:6Q9H|rcsb pdb:6Q9L|rcsb pdb:6Q9O|rcsb pdb:6SQO|rcsb pdb:6T2D|rcsb pdb:6T2E|rcsb pdb:6T2F|rcsb pdb:6Y4Q|rcsb pdb:7AD0|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BIR|rcsb pdb:7BIT|rcsb pdb:7BIV|rcsb pdb:7BJ0|rcsb pdb:7BJ6|rcsb pdb:7BMG|reactome:R-HSA-198323|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-399719|reactome:R-HSA-5674400|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69541|reactome:R-HSA-8941858|rcsb pdb:4UMN|rcsb pdb:4WT2|dip:DIP-392N|mint:MINT-6540802(identity)	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|mint:MINT-6540800(identity)	-	-	-	figure legend:F4a|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2008/05/07	2014/10/16	rogid:CFy2L9Et1jFtlApOFn2AKiGPWJ89606	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	intact-crc:A31C6A9F0C60AC6D|rigid:TaXqqLSzYzEOq7M/sUkK/LdrLVA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q00987	uniprotkb:P04637	intact:EBI-389668|intact:EBI-28980679|ensembl:ENSP00000444430|uniprotkb:A6NL51|uniprotkb:Q13226|uniprotkb:Q13297|uniprotkb:Q13298|uniprotkb:Q13299|uniprotkb:Q13300|uniprotkb:Q13301|uniprotkb:Q53XW0|uniprotkb:Q71TW9|uniprotkb:Q8WYJ1|uniprotkb:Q8WYJ2|uniprotkb:Q9UGI3|uniprotkb:Q9UMT8|uniprotkb:A8K2S6	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:mdm2_human(display_long)|uniprotkb:MDM2(gene name)|psi-mi:MDM2(display_short)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833215|mint:MINT-6540796|imex:IM-11563-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135679(gene)|ensembl:ENST00000539479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000258149|ensembl:ENSP00000258149|ensembl:ENST00000299252|ensembl:ENSP00000299252|ensembl:ENST00000360430|ensembl:ENSP00000353611|ensembl:ENST00000393413|ensembl:ENSP00000377065|ensembl:ENSP00000444430|refseq:NP_001138811.1|refseq:NP_001265391.1|refseq:NP_002383.2|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036369"(transcription factor catabolic process)|refseq:XP_005268929.1|refseq:XP_006719462.1|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|interpro:IPR044080|mint:Q00987|rcsb pdb:1RV1|rcsb pdb:1T4E|rcsb pdb:1T4F|rcsb pdb:1YCR|rcsb pdb:1Z1M|rcsb pdb:2AXI|rcsb pdb:2C6A|rcsb pdb:2C6B|rcsb pdb:2F1Y|rcsb pdb:2FOP|rcsb pdb:2GV2|rcsb pdb:2HDP|rcsb pdb:2LZG|rcsb pdb:2M86|rcsb pdb:2MPS|rcsb pdb:2RUH|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:3EQS|rcsb pdb:3G03|rcsb pdb:3IUX|rcsb pdb:3IWY|rcsb pdb:3JZK|rcsb pdb:3JZR|rcsb pdb:3JZS|rcsb pdb:3LBK|rcsb pdb:3LBL|rcsb pdb:3LNJ|rcsb pdb:3LNZ|rcsb pdb:3MQS|rcsb pdb:3TJ2|rcsb pdb:3TPX|rcsb pdb:3TU1|rcsb pdb:3V3B|rcsb pdb:3VBG|rcsb pdb:3VZV|rcsb pdb:3W69|rcsb pdb:4DIJ|rcsb pdb:4ERE|rcsb pdb:4ERF|rcsb pdb:4HBM|rcsb pdb:4HFZ|rcsb pdb:4HG7|rcsb pdb:4JV7|rcsb pdb:4JV9|rcsb pdb:4JVE|rcsb pdb:4JVR|rcsb pdb:4JWR|rcsb pdb:4MDN|rcsb pdb:4MDQ|rcsb pdb:4OAS|rcsb pdb:4OBA|rcsb pdb:4OCC|rcsb pdb:4ODE|rcsb pdb:4ODF|rcsb pdb:4OGN|rcsb pdb:4OGT|rcsb pdb:4OGV|rcsb pdb:4OQ3|rcsb pdb:4QO4|rcsb pdb:4QOC|rcsb pdb:4UD7|rcsb pdb:4UE1|rcsb pdb:4XXB|rcsb pdb:4ZFI|rcsb pdb:4ZGK|rcsb pdb:4ZYC|rcsb pdb:4ZYF|rcsb pdb:4ZYI|rcsb pdb:5AFG|rcsb pdb:5HMH|rcsb pdb:5HMI|rcsb pdb:5HMK|rcsb pdb:5J7F|rcsb pdb:5J7G|rcsb pdb:5LAV|rcsb pdb:5LAW|rcsb pdb:5C5A|rcsb pdb:5LAY|rcsb pdb:5LAZ|rcsb pdb:5LN2|rcsb pdb:5MNJ|rcsb pdb:5OAI|rcsb pdb:5OC8|rcsb pdb:5SWK|rcsb pdb:5TRF|rcsb pdb:5UMM|rcsb pdb:5VK0|rcsb pdb:5WTS|rcsb pdb:5XXK|rcsb pdb:5Z02|rcsb pdb:5ZXF|rcsb pdb:6AAW|rcsb pdb:6GGN|rcsb pdb:6H22|rcsb pdb:6HFA|rcsb pdb:6I29|rcsb pdb:6I3S|rcsb pdb:6IM9|rcsb pdb:6KZU|rcsb pdb:6Q96|rcsb pdb:6Q9H|rcsb pdb:6Q9L|rcsb pdb:6Q9O|rcsb pdb:6SQO|rcsb pdb:6T2D|rcsb pdb:6T2E|rcsb pdb:6T2F|rcsb pdb:6Y4Q|rcsb pdb:7AD0|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BIR|rcsb pdb:7BIT|rcsb pdb:7BIV|rcsb pdb:7BJ0|rcsb pdb:7BJ6|rcsb pdb:7BMG|reactome:R-HSA-198323|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-399719|reactome:R-HSA-5674400|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69541|reactome:R-HSA-8941858|rcsb pdb:4UMN|rcsb pdb:4WT2|dip:DIP-392N|mint:MINT-6540802(identity)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|mint:MINT-6540798(identity)	-	-	-	figure legend:F4a|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2008/05/07	2014/10/16	rogid:CFy2L9Et1jFtlApOFn2AKiGPWJ89606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:A31C6A9F0C60AC6D|rigid:TaXqqLSzYzEOq7M/sUkK/LdrLVA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04637	uniprotkb:P61289	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833199|mint:MINT-6540776|imex:IM-11563-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|mint:MINT-6540782(identity)	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|mint:MINT-6540788(identity)	-	-	-	figure legend:F4a|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2008/05/07	2014/10/16	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	intact-crc:E87E38372D5D4E93|rigid:TaXqqLSzYzEOq7M/sUkK/LdrLVA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04637	uniprotkb:Q00987	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	intact:EBI-389668|intact:EBI-28980679|ensembl:ENSP00000444430|uniprotkb:A6NL51|uniprotkb:Q13226|uniprotkb:Q13297|uniprotkb:Q13298|uniprotkb:Q13299|uniprotkb:Q13300|uniprotkb:Q13301|uniprotkb:Q53XW0|uniprotkb:Q71TW9|uniprotkb:Q8WYJ1|uniprotkb:Q8WYJ2|uniprotkb:Q9UGI3|uniprotkb:Q9UMT8|uniprotkb:A8K2S6	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:mdm2_human(display_long)|uniprotkb:MDM2(gene name)|psi-mi:MDM2(display_short)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833199|mint:MINT-6540776|imex:IM-11563-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|mint:MINT-6540782(identity)	ensembl:ENSG00000135679(gene)|ensembl:ENST00000539479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000258149|ensembl:ENSP00000258149|ensembl:ENST00000299252|ensembl:ENSP00000299252|ensembl:ENST00000360430|ensembl:ENSP00000353611|ensembl:ENST00000393413|ensembl:ENSP00000377065|ensembl:ENSP00000444430|refseq:NP_001138811.1|refseq:NP_001265391.1|refseq:NP_002383.2|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036369"(transcription factor catabolic process)|refseq:XP_005268929.1|refseq:XP_006719462.1|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|interpro:IPR044080|mint:Q00987|rcsb pdb:1RV1|rcsb pdb:1T4E|rcsb pdb:1T4F|rcsb pdb:1YCR|rcsb pdb:1Z1M|rcsb pdb:2AXI|rcsb pdb:2C6A|rcsb pdb:2C6B|rcsb pdb:2F1Y|rcsb pdb:2FOP|rcsb pdb:2GV2|rcsb pdb:2HDP|rcsb pdb:2LZG|rcsb pdb:2M86|rcsb pdb:2MPS|rcsb pdb:2RUH|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:3EQS|rcsb pdb:3G03|rcsb pdb:3IUX|rcsb pdb:3IWY|rcsb pdb:3JZK|rcsb pdb:3JZR|rcsb pdb:3JZS|rcsb pdb:3LBK|rcsb pdb:3LBL|rcsb pdb:3LNJ|rcsb pdb:3LNZ|rcsb pdb:3MQS|rcsb pdb:3TJ2|rcsb pdb:3TPX|rcsb pdb:3TU1|rcsb pdb:3V3B|rcsb pdb:3VBG|rcsb pdb:3VZV|rcsb pdb:3W69|rcsb pdb:4DIJ|rcsb pdb:4ERE|rcsb pdb:4ERF|rcsb pdb:4HBM|rcsb pdb:4HFZ|rcsb pdb:4HG7|rcsb pdb:4JV7|rcsb pdb:4JV9|rcsb pdb:4JVE|rcsb pdb:4JVR|rcsb pdb:4JWR|rcsb pdb:4MDN|rcsb pdb:4MDQ|rcsb pdb:4OAS|rcsb pdb:4OBA|rcsb pdb:4OCC|rcsb pdb:4ODE|rcsb pdb:4ODF|rcsb pdb:4OGN|rcsb pdb:4OGT|rcsb pdb:4OGV|rcsb pdb:4OQ3|rcsb pdb:4QO4|rcsb pdb:4QOC|rcsb pdb:4UD7|rcsb pdb:4UE1|rcsb pdb:4XXB|rcsb pdb:4ZFI|rcsb pdb:4ZGK|rcsb pdb:4ZYC|rcsb pdb:4ZYF|rcsb pdb:4ZYI|rcsb pdb:5AFG|rcsb pdb:5HMH|rcsb pdb:5HMI|rcsb pdb:5HMK|rcsb pdb:5J7F|rcsb pdb:5J7G|rcsb pdb:5LAV|rcsb pdb:5LAW|rcsb pdb:5C5A|rcsb pdb:5LAY|rcsb pdb:5LAZ|rcsb pdb:5LN2|rcsb pdb:5MNJ|rcsb pdb:5OAI|rcsb pdb:5OC8|rcsb pdb:5SWK|rcsb pdb:5TRF|rcsb pdb:5UMM|rcsb pdb:5VK0|rcsb pdb:5WTS|rcsb pdb:5XXK|rcsb pdb:5Z02|rcsb pdb:5ZXF|rcsb pdb:6AAW|rcsb pdb:6GGN|rcsb pdb:6H22|rcsb pdb:6HFA|rcsb pdb:6I29|rcsb pdb:6I3S|rcsb pdb:6IM9|rcsb pdb:6KZU|rcsb pdb:6Q96|rcsb pdb:6Q9H|rcsb pdb:6Q9L|rcsb pdb:6Q9O|rcsb pdb:6SQO|rcsb pdb:6T2D|rcsb pdb:6T2E|rcsb pdb:6T2F|rcsb pdb:6Y4Q|rcsb pdb:7AD0|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BIR|rcsb pdb:7BIT|rcsb pdb:7BIV|rcsb pdb:7BJ0|rcsb pdb:7BJ6|rcsb pdb:7BMG|reactome:R-HSA-198323|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-399719|reactome:R-HSA-5674400|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69541|reactome:R-HSA-8941858|rcsb pdb:4UMN|rcsb pdb:4WT2|dip:DIP-392N|mint:MINT-6540778(identity)	-	-	-	figure legend:F4a|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2008/05/07	2014/10/16	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rogid:CFy2L9Et1jFtlApOFn2AKiGPWJ89606	intact-crc:E87E38372D5D4E93|rigid:TaXqqLSzYzEOq7M/sUkK/LdrLVA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P61289	uniprotkb:Q00987	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	intact:EBI-389668|intact:EBI-28980679|ensembl:ENSP00000444430|uniprotkb:A6NL51|uniprotkb:Q13226|uniprotkb:Q13297|uniprotkb:Q13298|uniprotkb:Q13299|uniprotkb:Q13300|uniprotkb:Q13301|uniprotkb:Q53XW0|uniprotkb:Q71TW9|uniprotkb:Q8WYJ1|uniprotkb:Q8WYJ2|uniprotkb:Q9UGI3|uniprotkb:Q9UMT8|uniprotkb:A8K2S6	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:mdm2_human(display_long)|uniprotkb:MDM2(gene name)|psi-mi:MDM2(display_short)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833231|mint:MINT-6540807|imex:IM-11563-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|mint:MINT-6540813(identity)	ensembl:ENSG00000135679(gene)|ensembl:ENST00000539479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000258149|ensembl:ENSP00000258149|ensembl:ENST00000299252|ensembl:ENSP00000299252|ensembl:ENST00000360430|ensembl:ENSP00000353611|ensembl:ENST00000393413|ensembl:ENSP00000377065|ensembl:ENSP00000444430|refseq:NP_001138811.1|refseq:NP_001265391.1|refseq:NP_002383.2|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036369"(transcription factor catabolic process)|refseq:XP_005268929.1|refseq:XP_006719462.1|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|interpro:IPR044080|mint:Q00987|rcsb pdb:1RV1|rcsb pdb:1T4E|rcsb pdb:1T4F|rcsb pdb:1YCR|rcsb pdb:1Z1M|rcsb pdb:2AXI|rcsb pdb:2C6A|rcsb pdb:2C6B|rcsb pdb:2F1Y|rcsb pdb:2FOP|rcsb pdb:2GV2|rcsb pdb:2HDP|rcsb pdb:2LZG|rcsb pdb:2M86|rcsb pdb:2MPS|rcsb pdb:2RUH|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:3EQS|rcsb pdb:3G03|rcsb pdb:3IUX|rcsb pdb:3IWY|rcsb pdb:3JZK|rcsb pdb:3JZR|rcsb pdb:3JZS|rcsb pdb:3LBK|rcsb pdb:3LBL|rcsb pdb:3LNJ|rcsb pdb:3LNZ|rcsb pdb:3MQS|rcsb pdb:3TJ2|rcsb pdb:3TPX|rcsb pdb:3TU1|rcsb pdb:3V3B|rcsb pdb:3VBG|rcsb pdb:3VZV|rcsb pdb:3W69|rcsb pdb:4DIJ|rcsb pdb:4ERE|rcsb pdb:4ERF|rcsb pdb:4HBM|rcsb pdb:4HFZ|rcsb pdb:4HG7|rcsb pdb:4JV7|rcsb pdb:4JV9|rcsb pdb:4JVE|rcsb pdb:4JVR|rcsb pdb:4JWR|rcsb pdb:4MDN|rcsb pdb:4MDQ|rcsb pdb:4OAS|rcsb pdb:4OBA|rcsb pdb:4OCC|rcsb pdb:4ODE|rcsb pdb:4ODF|rcsb pdb:4OGN|rcsb pdb:4OGT|rcsb pdb:4OGV|rcsb pdb:4OQ3|rcsb pdb:4QO4|rcsb pdb:4QOC|rcsb pdb:4UD7|rcsb pdb:4UE1|rcsb pdb:4XXB|rcsb pdb:4ZFI|rcsb pdb:4ZGK|rcsb pdb:4ZYC|rcsb pdb:4ZYF|rcsb pdb:4ZYI|rcsb pdb:5AFG|rcsb pdb:5HMH|rcsb pdb:5HMI|rcsb pdb:5HMK|rcsb pdb:5J7F|rcsb pdb:5J7G|rcsb pdb:5LAV|rcsb pdb:5LAW|rcsb pdb:5C5A|rcsb pdb:5LAY|rcsb pdb:5LAZ|rcsb pdb:5LN2|rcsb pdb:5MNJ|rcsb pdb:5OAI|rcsb pdb:5OC8|rcsb pdb:5SWK|rcsb pdb:5TRF|rcsb pdb:5UMM|rcsb pdb:5VK0|rcsb pdb:5WTS|rcsb pdb:5XXK|rcsb pdb:5Z02|rcsb pdb:5ZXF|rcsb pdb:6AAW|rcsb pdb:6GGN|rcsb pdb:6H22|rcsb pdb:6HFA|rcsb pdb:6I29|rcsb pdb:6I3S|rcsb pdb:6IM9|rcsb pdb:6KZU|rcsb pdb:6Q96|rcsb pdb:6Q9H|rcsb pdb:6Q9L|rcsb pdb:6Q9O|rcsb pdb:6SQO|rcsb pdb:6T2D|rcsb pdb:6T2E|rcsb pdb:6T2F|rcsb pdb:6Y4Q|rcsb pdb:7AD0|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BIR|rcsb pdb:7BIT|rcsb pdb:7BIV|rcsb pdb:7BJ0|rcsb pdb:7BJ6|rcsb pdb:7BMG|reactome:R-HSA-198323|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-399719|reactome:R-HSA-5674400|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69541|reactome:R-HSA-8941858|rcsb pdb:4UMN|rcsb pdb:4WT2|dip:DIP-392N|mint:MINT-6540809(identity)	-	-	-	figure legend:F4a|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2008/05/07	2014/10/16	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	rogid:CFy2L9Et1jFtlApOFn2AKiGPWJ89606	intact-crc:AFC3244463D4FEA1|rigid:TaXqqLSzYzEOq7M/sUkK/LdrLVA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P61289	uniprotkb:P04637	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833231|mint:MINT-6540807|imex:IM-11563-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|mint:MINT-6540813(identity)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|mint:MINT-6540811(identity)	-	-	-	figure legend:F4a|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2008/05/07	2014/10/16	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:AFC3244463D4FEA1|rigid:TaXqqLSzYzEOq7M/sUkK/LdrLVA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04637	uniprotkb:P61289	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833274|mint:MINT-6540940|imex:IM-11563-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|mint:MINT-6540946(identity)	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|mint:MINT-6540950(identity)	-	-	-	figure legend:F4C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2008/05/07	2014/10/16	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	intact-crc:95D403B7EE382EF7|rigid:IMgb2og1wjLYSujCeB/HBJ2YPyg	false	ha tag:?-?(MINT-6540947)	green fluorescent protein tag:?-?(MINT-6540951)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61289	uniprotkb:P04637	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833293|mint:MINT-6540960|imex:IM-11563-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|mint:MINT-6540966(identity)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|mint:MINT-6540962(identity)	-	-	-	figure legend:F4C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2008/05/07	2014/10/16	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:DC6647B686049D3D|rigid:IMgb2og1wjLYSujCeB/HBJ2YPyg	false	green fluorescent protein tag:?-?(MINT-6540967)	ha tag:?-?(MINT-6540963)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00987	uniprotkb:P61289	intact:EBI-389668|intact:EBI-28980679|ensembl:ENSP00000444430|uniprotkb:A6NL51|uniprotkb:Q13226|uniprotkb:Q13297|uniprotkb:Q13298|uniprotkb:Q13299|uniprotkb:Q13300|uniprotkb:Q13301|uniprotkb:Q53XW0|uniprotkb:Q71TW9|uniprotkb:Q8WYJ1|uniprotkb:Q8WYJ2|uniprotkb:Q9UGI3|uniprotkb:Q9UMT8|uniprotkb:A8K2S6	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	psi-mi:mdm2_human(display_long)|uniprotkb:MDM2(gene name)|psi-mi:MDM2(display_short)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833312|mint:MINT-6540973|imex:IM-11563-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135679(gene)|ensembl:ENST00000539479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000258149|ensembl:ENSP00000258149|ensembl:ENST00000299252|ensembl:ENSP00000299252|ensembl:ENST00000360430|ensembl:ENSP00000353611|ensembl:ENST00000393413|ensembl:ENSP00000377065|ensembl:ENSP00000444430|refseq:NP_001138811.1|refseq:NP_001265391.1|refseq:NP_002383.2|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036369"(transcription factor catabolic process)|refseq:XP_005268929.1|refseq:XP_006719462.1|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|interpro:IPR044080|mint:Q00987|rcsb pdb:1RV1|rcsb pdb:1T4E|rcsb pdb:1T4F|rcsb pdb:1YCR|rcsb pdb:1Z1M|rcsb pdb:2AXI|rcsb pdb:2C6A|rcsb pdb:2C6B|rcsb pdb:2F1Y|rcsb pdb:2FOP|rcsb pdb:2GV2|rcsb pdb:2HDP|rcsb pdb:2LZG|rcsb pdb:2M86|rcsb pdb:2MPS|rcsb pdb:2RUH|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:3EQS|rcsb pdb:3G03|rcsb pdb:3IUX|rcsb pdb:3IWY|rcsb pdb:3JZK|rcsb pdb:3JZR|rcsb pdb:3JZS|rcsb pdb:3LBK|rcsb pdb:3LBL|rcsb pdb:3LNJ|rcsb pdb:3LNZ|rcsb pdb:3MQS|rcsb pdb:3TJ2|rcsb pdb:3TPX|rcsb pdb:3TU1|rcsb pdb:3V3B|rcsb pdb:3VBG|rcsb pdb:3VZV|rcsb pdb:3W69|rcsb pdb:4DIJ|rcsb pdb:4ERE|rcsb pdb:4ERF|rcsb pdb:4HBM|rcsb pdb:4HFZ|rcsb pdb:4HG7|rcsb pdb:4JV7|rcsb pdb:4JV9|rcsb pdb:4JVE|rcsb pdb:4JVR|rcsb pdb:4JWR|rcsb pdb:4MDN|rcsb pdb:4MDQ|rcsb pdb:4OAS|rcsb pdb:4OBA|rcsb pdb:4OCC|rcsb pdb:4ODE|rcsb pdb:4ODF|rcsb pdb:4OGN|rcsb pdb:4OGT|rcsb pdb:4OGV|rcsb pdb:4OQ3|rcsb pdb:4QO4|rcsb pdb:4QOC|rcsb pdb:4UD7|rcsb pdb:4UE1|rcsb pdb:4XXB|rcsb pdb:4ZFI|rcsb pdb:4ZGK|rcsb pdb:4ZYC|rcsb pdb:4ZYF|rcsb pdb:4ZYI|rcsb pdb:5AFG|rcsb pdb:5HMH|rcsb pdb:5HMI|rcsb pdb:5HMK|rcsb pdb:5J7F|rcsb pdb:5J7G|rcsb pdb:5LAV|rcsb pdb:5LAW|rcsb pdb:5C5A|rcsb pdb:5LAY|rcsb pdb:5LAZ|rcsb pdb:5LN2|rcsb pdb:5MNJ|rcsb pdb:5OAI|rcsb pdb:5OC8|rcsb pdb:5SWK|rcsb pdb:5TRF|rcsb pdb:5UMM|rcsb pdb:5VK0|rcsb pdb:5WTS|rcsb pdb:5XXK|rcsb pdb:5Z02|rcsb pdb:5ZXF|rcsb pdb:6AAW|rcsb pdb:6GGN|rcsb pdb:6H22|rcsb pdb:6HFA|rcsb pdb:6I29|rcsb pdb:6I3S|rcsb pdb:6IM9|rcsb pdb:6KZU|rcsb pdb:6Q96|rcsb pdb:6Q9H|rcsb pdb:6Q9L|rcsb pdb:6Q9O|rcsb pdb:6SQO|rcsb pdb:6T2D|rcsb pdb:6T2E|rcsb pdb:6T2F|rcsb pdb:6Y4Q|rcsb pdb:7AD0|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BIR|rcsb pdb:7BIT|rcsb pdb:7BIV|rcsb pdb:7BJ0|rcsb pdb:7BJ6|rcsb pdb:7BMG|reactome:R-HSA-198323|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-399719|reactome:R-HSA-5674400|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69541|reactome:R-HSA-8941858|rcsb pdb:4UMN|rcsb pdb:4WT2|dip:DIP-392N|mint:MINT-6540979(identity)	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|mint:MINT-6540975(identity)	-	-	-	figure legend:F4C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2008/05/07	2014/10/16	rogid:CFy2L9Et1jFtlApOFn2AKiGPWJ89606	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	intact-crc:ACAC76952562176C|rigid:Rg/g3PBIFGjoy/B63P3xuLJBE4I	false	t7 tag:?-?(MINT-6540980)	green fluorescent protein tag:?-?(MINT-6540976)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q00987	uniprotkb:P61289	intact:EBI-389668|intact:EBI-28980679|ensembl:ENSP00000444430|uniprotkb:A6NL51|uniprotkb:Q13226|uniprotkb:Q13297|uniprotkb:Q13298|uniprotkb:Q13299|uniprotkb:Q13300|uniprotkb:Q13301|uniprotkb:Q53XW0|uniprotkb:Q71TW9|uniprotkb:Q8WYJ1|uniprotkb:Q8WYJ2|uniprotkb:Q9UGI3|uniprotkb:Q9UMT8|uniprotkb:A8K2S6	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	psi-mi:mdm2_human(display_long)|uniprotkb:MDM2(gene name)|psi-mi:MDM2(display_short)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833331|mint:MINT-6540985|imex:IM-11563-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135679(gene)|ensembl:ENST00000539479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000258149|ensembl:ENSP00000258149|ensembl:ENST00000299252|ensembl:ENSP00000299252|ensembl:ENST00000360430|ensembl:ENSP00000353611|ensembl:ENST00000393413|ensembl:ENSP00000377065|ensembl:ENSP00000444430|refseq:NP_001138811.1|refseq:NP_001265391.1|refseq:NP_002383.2|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036369"(transcription factor catabolic process)|refseq:XP_005268929.1|refseq:XP_006719462.1|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|interpro:IPR044080|mint:Q00987|rcsb pdb:1RV1|rcsb pdb:1T4E|rcsb pdb:1T4F|rcsb pdb:1YCR|rcsb pdb:1Z1M|rcsb pdb:2AXI|rcsb pdb:2C6A|rcsb pdb:2C6B|rcsb pdb:2F1Y|rcsb pdb:2FOP|rcsb pdb:2GV2|rcsb pdb:2HDP|rcsb pdb:2LZG|rcsb pdb:2M86|rcsb pdb:2MPS|rcsb pdb:2RUH|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:3EQS|rcsb pdb:3G03|rcsb pdb:3IUX|rcsb pdb:3IWY|rcsb pdb:3JZK|rcsb pdb:3JZR|rcsb pdb:3JZS|rcsb pdb:3LBK|rcsb pdb:3LBL|rcsb pdb:3LNJ|rcsb pdb:3LNZ|rcsb pdb:3MQS|rcsb pdb:3TJ2|rcsb pdb:3TPX|rcsb pdb:3TU1|rcsb pdb:3V3B|rcsb pdb:3VBG|rcsb pdb:3VZV|rcsb pdb:3W69|rcsb pdb:4DIJ|rcsb pdb:4ERE|rcsb pdb:4ERF|rcsb pdb:4HBM|rcsb pdb:4HFZ|rcsb pdb:4HG7|rcsb pdb:4JV7|rcsb pdb:4JV9|rcsb pdb:4JVE|rcsb pdb:4JVR|rcsb pdb:4JWR|rcsb pdb:4MDN|rcsb pdb:4MDQ|rcsb pdb:4OAS|rcsb pdb:4OBA|rcsb pdb:4OCC|rcsb pdb:4ODE|rcsb pdb:4ODF|rcsb pdb:4OGN|rcsb pdb:4OGT|rcsb pdb:4OGV|rcsb pdb:4OQ3|rcsb pdb:4QO4|rcsb pdb:4QOC|rcsb pdb:4UD7|rcsb pdb:4UE1|rcsb pdb:4XXB|rcsb pdb:4ZFI|rcsb pdb:4ZGK|rcsb pdb:4ZYC|rcsb pdb:4ZYF|rcsb pdb:4ZYI|rcsb pdb:5AFG|rcsb pdb:5HMH|rcsb pdb:5HMI|rcsb pdb:5HMK|rcsb pdb:5J7F|rcsb pdb:5J7G|rcsb pdb:5LAV|rcsb pdb:5LAW|rcsb pdb:5C5A|rcsb pdb:5LAY|rcsb pdb:5LAZ|rcsb pdb:5LN2|rcsb pdb:5MNJ|rcsb pdb:5OAI|rcsb pdb:5OC8|rcsb pdb:5SWK|rcsb pdb:5TRF|rcsb pdb:5UMM|rcsb pdb:5VK0|rcsb pdb:5WTS|rcsb pdb:5XXK|rcsb pdb:5Z02|rcsb pdb:5ZXF|rcsb pdb:6AAW|rcsb pdb:6GGN|rcsb pdb:6H22|rcsb pdb:6HFA|rcsb pdb:6I29|rcsb pdb:6I3S|rcsb pdb:6IM9|rcsb pdb:6KZU|rcsb pdb:6Q96|rcsb pdb:6Q9H|rcsb pdb:6Q9L|rcsb pdb:6Q9O|rcsb pdb:6SQO|rcsb pdb:6T2D|rcsb pdb:6T2E|rcsb pdb:6T2F|rcsb pdb:6Y4Q|rcsb pdb:7AD0|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BIR|rcsb pdb:7BIT|rcsb pdb:7BIV|rcsb pdb:7BJ0|rcsb pdb:7BJ6|rcsb pdb:7BMG|reactome:R-HSA-198323|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-399719|reactome:R-HSA-5674400|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69541|reactome:R-HSA-8941858|rcsb pdb:4UMN|rcsb pdb:4WT2|dip:DIP-392N|mint:MINT-6540987(identity)	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|mint:MINT-6540991(identity)	-	-	-	figure legend:F4C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2008/05/07	2014/10/16	rogid:CFy2L9Et1jFtlApOFn2AKiGPWJ89606	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	intact-crc:CFA9F377B8FCC900|rigid:Rg/g3PBIFGjoy/B63P3xuLJBE4I	false	t7 tag:?-?(MINT-6540988)	green fluorescent protein tag:?-?(MINT-6540992)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61289	uniprotkb:Q00987	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	intact:EBI-389668|intact:EBI-28980679|ensembl:ENSP00000444430|uniprotkb:A6NL51|uniprotkb:Q13226|uniprotkb:Q13297|uniprotkb:Q13298|uniprotkb:Q13299|uniprotkb:Q13300|uniprotkb:Q13301|uniprotkb:Q53XW0|uniprotkb:Q71TW9|uniprotkb:Q8WYJ1|uniprotkb:Q8WYJ2|uniprotkb:Q9UGI3|uniprotkb:Q9UMT8|uniprotkb:A8K2S6	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:mdm2_human(display_long)|uniprotkb:MDM2(gene name)|psi-mi:MDM2(display_short)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833350|mint:MINT-6540998|imex:IM-11563-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|mint:MINT-6541000(identity)	ensembl:ENSG00000135679(gene)|ensembl:ENST00000539479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000258149|ensembl:ENSP00000258149|ensembl:ENST00000299252|ensembl:ENSP00000299252|ensembl:ENST00000360430|ensembl:ENSP00000353611|ensembl:ENST00000393413|ensembl:ENSP00000377065|ensembl:ENSP00000444430|refseq:NP_001138811.1|refseq:NP_001265391.1|refseq:NP_002383.2|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036369"(transcription factor catabolic process)|refseq:XP_005268929.1|refseq:XP_006719462.1|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|interpro:IPR044080|mint:Q00987|rcsb pdb:1RV1|rcsb pdb:1T4E|rcsb pdb:1T4F|rcsb pdb:1YCR|rcsb pdb:1Z1M|rcsb pdb:2AXI|rcsb pdb:2C6A|rcsb pdb:2C6B|rcsb pdb:2F1Y|rcsb pdb:2FOP|rcsb pdb:2GV2|rcsb pdb:2HDP|rcsb pdb:2LZG|rcsb pdb:2M86|rcsb pdb:2MPS|rcsb pdb:2RUH|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:3EQS|rcsb pdb:3G03|rcsb pdb:3IUX|rcsb pdb:3IWY|rcsb pdb:3JZK|rcsb pdb:3JZR|rcsb pdb:3JZS|rcsb pdb:3LBK|rcsb pdb:3LBL|rcsb pdb:3LNJ|rcsb pdb:3LNZ|rcsb pdb:3MQS|rcsb pdb:3TJ2|rcsb pdb:3TPX|rcsb pdb:3TU1|rcsb pdb:3V3B|rcsb pdb:3VBG|rcsb pdb:3VZV|rcsb pdb:3W69|rcsb pdb:4DIJ|rcsb pdb:4ERE|rcsb pdb:4ERF|rcsb pdb:4HBM|rcsb pdb:4HFZ|rcsb pdb:4HG7|rcsb pdb:4JV7|rcsb pdb:4JV9|rcsb pdb:4JVE|rcsb pdb:4JVR|rcsb pdb:4JWR|rcsb pdb:4MDN|rcsb pdb:4MDQ|rcsb pdb:4OAS|rcsb pdb:4OBA|rcsb pdb:4OCC|rcsb pdb:4ODE|rcsb pdb:4ODF|rcsb pdb:4OGN|rcsb pdb:4OGT|rcsb pdb:4OGV|rcsb pdb:4OQ3|rcsb pdb:4QO4|rcsb pdb:4QOC|rcsb pdb:4UD7|rcsb pdb:4UE1|rcsb pdb:4XXB|rcsb pdb:4ZFI|rcsb pdb:4ZGK|rcsb pdb:4ZYC|rcsb pdb:4ZYF|rcsb pdb:4ZYI|rcsb pdb:5AFG|rcsb pdb:5HMH|rcsb pdb:5HMI|rcsb pdb:5HMK|rcsb pdb:5J7F|rcsb pdb:5J7G|rcsb pdb:5LAV|rcsb pdb:5LAW|rcsb pdb:5C5A|rcsb pdb:5LAY|rcsb pdb:5LAZ|rcsb pdb:5LN2|rcsb pdb:5MNJ|rcsb pdb:5OAI|rcsb pdb:5OC8|rcsb pdb:5SWK|rcsb pdb:5TRF|rcsb pdb:5UMM|rcsb pdb:5VK0|rcsb pdb:5WTS|rcsb pdb:5XXK|rcsb pdb:5Z02|rcsb pdb:5ZXF|rcsb pdb:6AAW|rcsb pdb:6GGN|rcsb pdb:6H22|rcsb pdb:6HFA|rcsb pdb:6I29|rcsb pdb:6I3S|rcsb pdb:6IM9|rcsb pdb:6KZU|rcsb pdb:6Q96|rcsb pdb:6Q9H|rcsb pdb:6Q9L|rcsb pdb:6Q9O|rcsb pdb:6SQO|rcsb pdb:6T2D|rcsb pdb:6T2E|rcsb pdb:6T2F|rcsb pdb:6Y4Q|rcsb pdb:7AD0|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BIR|rcsb pdb:7BIT|rcsb pdb:7BIV|rcsb pdb:7BJ0|rcsb pdb:7BJ6|rcsb pdb:7BMG|reactome:R-HSA-198323|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-399719|reactome:R-HSA-5674400|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69541|reactome:R-HSA-8941858|rcsb pdb:4UMN|rcsb pdb:4WT2|dip:DIP-392N|mint:MINT-6541004(identity)	-	-	-	figure legend:F5D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2008/05/07	2014/10/16	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	rogid:CFy2L9Et1jFtlApOFn2AKiGPWJ89606	intact-crc:FEB5FA53FD05F8A2|rigid:Rg/g3PBIFGjoy/B63P3xuLJBE4I	false	mutation disrupting interaction:76-103(MINT-6541012)|green fluorescent protein tag:?-?(MINT-6541001)|binding-associated region:?-?(MINT-6541010)	t7 tag:?-?(MINT-6541005)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P61289	uniprotkb:P04637	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833397|mint:MINT-6541016|imex:IM-11563-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|mint:MINT-6541022(identity)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|mint:MINT-6541018(identity)	-	-	-	figure legend:F5E|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2008/05/07	2014/10/16	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:DDAC8F3EACD36D37|rigid:IMgb2og1wjLYSujCeB/HBJ2YPyg	false	mutation disrupting interaction:76-103(MINT-6541023)|binding-associated region:?-?(MINT-6541025)|green fluorescent protein tag:?-?(MINT-6541027)	ha tag:?-?(MINT-6541019)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P61289	uniprotkb:Q00987	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	intact:EBI-389668|intact:EBI-28980679|ensembl:ENSP00000444430|uniprotkb:A6NL51|uniprotkb:Q13226|uniprotkb:Q13297|uniprotkb:Q13298|uniprotkb:Q13299|uniprotkb:Q13300|uniprotkb:Q13301|uniprotkb:Q53XW0|uniprotkb:Q71TW9|uniprotkb:Q8WYJ1|uniprotkb:Q8WYJ2|uniprotkb:Q9UGI3|uniprotkb:Q9UMT8|uniprotkb:A8K2S6	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:mdm2_human(display_long)|uniprotkb:MDM2(gene name)|psi-mi:MDM2(display_short)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833437|mint:MINT-6540837|imex:IM-11563-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|mint:MINT-6540839(identity)	ensembl:ENSG00000135679(gene)|ensembl:ENST00000539479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000258149|ensembl:ENSP00000258149|ensembl:ENST00000299252|ensembl:ENSP00000299252|ensembl:ENST00000360430|ensembl:ENSP00000353611|ensembl:ENST00000393413|ensembl:ENSP00000377065|ensembl:ENSP00000444430|refseq:NP_001138811.1|refseq:NP_001265391.1|refseq:NP_002383.2|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036369"(transcription factor catabolic process)|refseq:XP_005268929.1|refseq:XP_006719462.1|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|interpro:IPR044080|mint:Q00987|rcsb pdb:1RV1|rcsb pdb:1T4E|rcsb pdb:1T4F|rcsb pdb:1YCR|rcsb pdb:1Z1M|rcsb pdb:2AXI|rcsb pdb:2C6A|rcsb pdb:2C6B|rcsb pdb:2F1Y|rcsb pdb:2FOP|rcsb pdb:2GV2|rcsb pdb:2HDP|rcsb pdb:2LZG|rcsb pdb:2M86|rcsb pdb:2MPS|rcsb pdb:2RUH|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:3EQS|rcsb pdb:3G03|rcsb pdb:3IUX|rcsb pdb:3IWY|rcsb pdb:3JZK|rcsb pdb:3JZR|rcsb pdb:3JZS|rcsb pdb:3LBK|rcsb pdb:3LBL|rcsb pdb:3LNJ|rcsb pdb:3LNZ|rcsb pdb:3MQS|rcsb pdb:3TJ2|rcsb pdb:3TPX|rcsb pdb:3TU1|rcsb pdb:3V3B|rcsb pdb:3VBG|rcsb pdb:3VZV|rcsb pdb:3W69|rcsb pdb:4DIJ|rcsb pdb:4ERE|rcsb pdb:4ERF|rcsb pdb:4HBM|rcsb pdb:4HFZ|rcsb pdb:4HG7|rcsb pdb:4JV7|rcsb pdb:4JV9|rcsb pdb:4JVE|rcsb pdb:4JVR|rcsb pdb:4JWR|rcsb pdb:4MDN|rcsb pdb:4MDQ|rcsb pdb:4OAS|rcsb pdb:4OBA|rcsb pdb:4OCC|rcsb pdb:4ODE|rcsb pdb:4ODF|rcsb pdb:4OGN|rcsb pdb:4OGT|rcsb pdb:4OGV|rcsb pdb:4OQ3|rcsb pdb:4QO4|rcsb pdb:4QOC|rcsb pdb:4UD7|rcsb pdb:4UE1|rcsb pdb:4XXB|rcsb pdb:4ZFI|rcsb pdb:4ZGK|rcsb pdb:4ZYC|rcsb pdb:4ZYF|rcsb pdb:4ZYI|rcsb pdb:5AFG|rcsb pdb:5HMH|rcsb pdb:5HMI|rcsb pdb:5HMK|rcsb pdb:5J7F|rcsb pdb:5J7G|rcsb pdb:5LAV|rcsb pdb:5LAW|rcsb pdb:5C5A|rcsb pdb:5LAY|rcsb pdb:5LAZ|rcsb pdb:5LN2|rcsb pdb:5MNJ|rcsb pdb:5OAI|rcsb pdb:5OC8|rcsb pdb:5SWK|rcsb pdb:5TRF|rcsb pdb:5UMM|rcsb pdb:5VK0|rcsb pdb:5WTS|rcsb pdb:5XXK|rcsb pdb:5Z02|rcsb pdb:5ZXF|rcsb pdb:6AAW|rcsb pdb:6GGN|rcsb pdb:6H22|rcsb pdb:6HFA|rcsb pdb:6I29|rcsb pdb:6I3S|rcsb pdb:6IM9|rcsb pdb:6KZU|rcsb pdb:6Q96|rcsb pdb:6Q9H|rcsb pdb:6Q9L|rcsb pdb:6Q9O|rcsb pdb:6SQO|rcsb pdb:6T2D|rcsb pdb:6T2E|rcsb pdb:6T2F|rcsb pdb:6Y4Q|rcsb pdb:7AD0|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BIR|rcsb pdb:7BIT|rcsb pdb:7BIV|rcsb pdb:7BJ0|rcsb pdb:7BJ6|rcsb pdb:7BMG|reactome:R-HSA-198323|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-399719|reactome:R-HSA-5674400|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69541|reactome:R-HSA-8941858|rcsb pdb:4UMN|rcsb pdb:4WT2|dip:DIP-392N|mint:MINT-6540841(identity)	-	-	-	figure legend:F4B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/07	2014/10/16	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	rogid:CFy2L9Et1jFtlApOFn2AKiGPWJ89606	intact-crc:BD590F37B6E95649|rigid:Rg/g3PBIFGjoy/B63P3xuLJBE4I	false	-	glutathione s tranferase tag:?-?(MINT-6540849)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04637	uniprotkb:P61289	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833469|mint:MINT-6540866|imex:IM-11563-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|mint:MINT-6540872(identity)	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|mint:MINT-6540868(identity)	-	-	-	figure legend:F4B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/07	2014/10/16	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	intact-crc:15E2B5B8F5C94B4E|rigid:IMgb2og1wjLYSujCeB/HBJ2YPyg	false	-	glutathione s tranferase tag:?-?(MINT-6540869)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61289	uniprotkb:Q00987	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	intact:EBI-389668|intact:EBI-28980679|ensembl:ENSP00000444430|uniprotkb:A6NL51|uniprotkb:Q13226|uniprotkb:Q13297|uniprotkb:Q13298|uniprotkb:Q13299|uniprotkb:Q13300|uniprotkb:Q13301|uniprotkb:Q53XW0|uniprotkb:Q71TW9|uniprotkb:Q8WYJ1|uniprotkb:Q8WYJ2|uniprotkb:Q9UGI3|uniprotkb:Q9UMT8|uniprotkb:A8K2S6	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:mdm2_human(display_long)|uniprotkb:MDM2(gene name)|psi-mi:MDM2(display_short)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833453|mint:MINT-6540853|imex:IM-11563-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|mint:MINT-6540855(identity)	ensembl:ENSG00000135679(gene)|ensembl:ENST00000539479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000258149|ensembl:ENSP00000258149|ensembl:ENST00000299252|ensembl:ENSP00000299252|ensembl:ENST00000360430|ensembl:ENSP00000353611|ensembl:ENST00000393413|ensembl:ENSP00000377065|ensembl:ENSP00000444430|refseq:NP_001138811.1|refseq:NP_001265391.1|refseq:NP_002383.2|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036369"(transcription factor catabolic process)|refseq:XP_005268929.1|refseq:XP_006719462.1|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|interpro:IPR044080|mint:Q00987|rcsb pdb:1RV1|rcsb pdb:1T4E|rcsb pdb:1T4F|rcsb pdb:1YCR|rcsb pdb:1Z1M|rcsb pdb:2AXI|rcsb pdb:2C6A|rcsb pdb:2C6B|rcsb pdb:2F1Y|rcsb pdb:2FOP|rcsb pdb:2GV2|rcsb pdb:2HDP|rcsb pdb:2LZG|rcsb pdb:2M86|rcsb pdb:2MPS|rcsb pdb:2RUH|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:3EQS|rcsb pdb:3G03|rcsb pdb:3IUX|rcsb pdb:3IWY|rcsb pdb:3JZK|rcsb pdb:3JZR|rcsb pdb:3JZS|rcsb pdb:3LBK|rcsb pdb:3LBL|rcsb pdb:3LNJ|rcsb pdb:3LNZ|rcsb pdb:3MQS|rcsb pdb:3TJ2|rcsb pdb:3TPX|rcsb pdb:3TU1|rcsb pdb:3V3B|rcsb pdb:3VBG|rcsb pdb:3VZV|rcsb pdb:3W69|rcsb pdb:4DIJ|rcsb pdb:4ERE|rcsb pdb:4ERF|rcsb pdb:4HBM|rcsb pdb:4HFZ|rcsb pdb:4HG7|rcsb pdb:4JV7|rcsb pdb:4JV9|rcsb pdb:4JVE|rcsb pdb:4JVR|rcsb pdb:4JWR|rcsb pdb:4MDN|rcsb pdb:4MDQ|rcsb pdb:4OAS|rcsb pdb:4OBA|rcsb pdb:4OCC|rcsb pdb:4ODE|rcsb pdb:4ODF|rcsb pdb:4OGN|rcsb pdb:4OGT|rcsb pdb:4OGV|rcsb pdb:4OQ3|rcsb pdb:4QO4|rcsb pdb:4QOC|rcsb pdb:4UD7|rcsb pdb:4UE1|rcsb pdb:4XXB|rcsb pdb:4ZFI|rcsb pdb:4ZGK|rcsb pdb:4ZYC|rcsb pdb:4ZYF|rcsb pdb:4ZYI|rcsb pdb:5AFG|rcsb pdb:5HMH|rcsb pdb:5HMI|rcsb pdb:5HMK|rcsb pdb:5J7F|rcsb pdb:5J7G|rcsb pdb:5LAV|rcsb pdb:5LAW|rcsb pdb:5C5A|rcsb pdb:5LAY|rcsb pdb:5LAZ|rcsb pdb:5LN2|rcsb pdb:5MNJ|rcsb pdb:5OAI|rcsb pdb:5OC8|rcsb pdb:5SWK|rcsb pdb:5TRF|rcsb pdb:5UMM|rcsb pdb:5VK0|rcsb pdb:5WTS|rcsb pdb:5XXK|rcsb pdb:5Z02|rcsb pdb:5ZXF|rcsb pdb:6AAW|rcsb pdb:6GGN|rcsb pdb:6H22|rcsb pdb:6HFA|rcsb pdb:6I29|rcsb pdb:6I3S|rcsb pdb:6IM9|rcsb pdb:6KZU|rcsb pdb:6Q96|rcsb pdb:6Q9H|rcsb pdb:6Q9L|rcsb pdb:6Q9O|rcsb pdb:6SQO|rcsb pdb:6T2D|rcsb pdb:6T2E|rcsb pdb:6T2F|rcsb pdb:6Y4Q|rcsb pdb:7AD0|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BIR|rcsb pdb:7BIT|rcsb pdb:7BIV|rcsb pdb:7BJ0|rcsb pdb:7BJ6|rcsb pdb:7BMG|reactome:R-HSA-198323|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-399719|reactome:R-HSA-5674400|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69541|reactome:R-HSA-8941858|rcsb pdb:4UMN|rcsb pdb:4WT2|dip:DIP-392N|mint:MINT-6540857(identity)	-	-	-	figure legend:F4B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/07	2014/10/16	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	rogid:CFy2L9Et1jFtlApOFn2AKiGPWJ89606	intact-crc:0DBAAC3D40ABC307|rigid:Rg/g3PBIFGjoy/B63P3xuLJBE4I	false	glutathione s tranferase tag:?-?(MINT-6540863)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q00987	uniprotkb:P04637	intact:EBI-389668|intact:EBI-28980679|ensembl:ENSP00000444430|uniprotkb:A6NL51|uniprotkb:Q13226|uniprotkb:Q13297|uniprotkb:Q13298|uniprotkb:Q13299|uniprotkb:Q13300|uniprotkb:Q13301|uniprotkb:Q53XW0|uniprotkb:Q71TW9|uniprotkb:Q8WYJ1|uniprotkb:Q8WYJ2|uniprotkb:Q9UGI3|uniprotkb:Q9UMT8|uniprotkb:A8K2S6	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:mdm2_human(display_long)|uniprotkb:MDM2(gene name)|psi-mi:MDM2(display_short)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833501|mint:MINT-6540889|imex:IM-11563-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135679(gene)|ensembl:ENST00000539479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000258149|ensembl:ENSP00000258149|ensembl:ENST00000299252|ensembl:ENSP00000299252|ensembl:ENST00000360430|ensembl:ENSP00000353611|ensembl:ENST00000393413|ensembl:ENSP00000377065|ensembl:ENSP00000444430|refseq:NP_001138811.1|refseq:NP_001265391.1|refseq:NP_002383.2|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036369"(transcription factor catabolic process)|refseq:XP_005268929.1|refseq:XP_006719462.1|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|interpro:IPR044080|mint:Q00987|rcsb pdb:1RV1|rcsb pdb:1T4E|rcsb pdb:1T4F|rcsb pdb:1YCR|rcsb pdb:1Z1M|rcsb pdb:2AXI|rcsb pdb:2C6A|rcsb pdb:2C6B|rcsb pdb:2F1Y|rcsb pdb:2FOP|rcsb pdb:2GV2|rcsb pdb:2HDP|rcsb pdb:2LZG|rcsb pdb:2M86|rcsb pdb:2MPS|rcsb pdb:2RUH|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:3EQS|rcsb pdb:3G03|rcsb pdb:3IUX|rcsb pdb:3IWY|rcsb pdb:3JZK|rcsb pdb:3JZR|rcsb pdb:3JZS|rcsb pdb:3LBK|rcsb pdb:3LBL|rcsb pdb:3LNJ|rcsb pdb:3LNZ|rcsb pdb:3MQS|rcsb pdb:3TJ2|rcsb pdb:3TPX|rcsb pdb:3TU1|rcsb pdb:3V3B|rcsb pdb:3VBG|rcsb pdb:3VZV|rcsb pdb:3W69|rcsb pdb:4DIJ|rcsb pdb:4ERE|rcsb pdb:4ERF|rcsb pdb:4HBM|rcsb pdb:4HFZ|rcsb pdb:4HG7|rcsb pdb:4JV7|rcsb pdb:4JV9|rcsb pdb:4JVE|rcsb pdb:4JVR|rcsb pdb:4JWR|rcsb pdb:4MDN|rcsb pdb:4MDQ|rcsb pdb:4OAS|rcsb pdb:4OBA|rcsb pdb:4OCC|rcsb pdb:4ODE|rcsb pdb:4ODF|rcsb pdb:4OGN|rcsb pdb:4OGT|rcsb pdb:4OGV|rcsb pdb:4OQ3|rcsb pdb:4QO4|rcsb pdb:4QOC|rcsb pdb:4UD7|rcsb pdb:4UE1|rcsb pdb:4XXB|rcsb pdb:4ZFI|rcsb pdb:4ZGK|rcsb pdb:4ZYC|rcsb pdb:4ZYF|rcsb pdb:4ZYI|rcsb pdb:5AFG|rcsb pdb:5HMH|rcsb pdb:5HMI|rcsb pdb:5HMK|rcsb pdb:5J7F|rcsb pdb:5J7G|rcsb pdb:5LAV|rcsb pdb:5LAW|rcsb pdb:5C5A|rcsb pdb:5LAY|rcsb pdb:5LAZ|rcsb pdb:5LN2|rcsb pdb:5MNJ|rcsb pdb:5OAI|rcsb pdb:5OC8|rcsb pdb:5SWK|rcsb pdb:5TRF|rcsb pdb:5UMM|rcsb pdb:5VK0|rcsb pdb:5WTS|rcsb pdb:5XXK|rcsb pdb:5Z02|rcsb pdb:5ZXF|rcsb pdb:6AAW|rcsb pdb:6GGN|rcsb pdb:6H22|rcsb pdb:6HFA|rcsb pdb:6I29|rcsb pdb:6I3S|rcsb pdb:6IM9|rcsb pdb:6KZU|rcsb pdb:6Q96|rcsb pdb:6Q9H|rcsb pdb:6Q9L|rcsb pdb:6Q9O|rcsb pdb:6SQO|rcsb pdb:6T2D|rcsb pdb:6T2E|rcsb pdb:6T2F|rcsb pdb:6Y4Q|rcsb pdb:7AD0|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BIR|rcsb pdb:7BIT|rcsb pdb:7BIV|rcsb pdb:7BJ0|rcsb pdb:7BJ6|rcsb pdb:7BMG|reactome:R-HSA-198323|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-399719|reactome:R-HSA-5674400|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69541|reactome:R-HSA-8941858|rcsb pdb:4UMN|rcsb pdb:4WT2|dip:DIP-392N|mint:MINT-6540891(identity)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|mint:MINT-6540893(identity)	-	-	-	figure legend:F4E|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/07	2014/10/16	rogid:CFy2L9Et1jFtlApOFn2AKiGPWJ89606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:BCBAD77DE50D99E0|rigid:dqcQ3QDCTDZxf8Q5dqA5O01HXZ8	false	glutathione s tranferase tag:?-?(MINT-6540902)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P61289	uniprotkb:P04637	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833485|mint:MINT-6540876|imex:IM-11563-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|mint:MINT-6540880(identity)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|mint:MINT-6540878(identity)	-	-	-	figure legend:F4B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/07	2014/10/16	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:6391DE07AC8125D1|rigid:IMgb2og1wjLYSujCeB/HBJ2YPyg	false	-	glutathione s tranferase tag:?-?(MINT-6540885)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00987	uniprotkb:P04637	intact:EBI-389668|intact:EBI-28980679|ensembl:ENSP00000444430|uniprotkb:A6NL51|uniprotkb:Q13226|uniprotkb:Q13297|uniprotkb:Q13298|uniprotkb:Q13299|uniprotkb:Q13300|uniprotkb:Q13301|uniprotkb:Q53XW0|uniprotkb:Q71TW9|uniprotkb:Q8WYJ1|uniprotkb:Q8WYJ2|uniprotkb:Q9UGI3|uniprotkb:Q9UMT8|uniprotkb:A8K2S6	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:mdm2_human(display_long)|uniprotkb:MDM2(gene name)|psi-mi:MDM2(display_short)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833545|mint:MINT-6540905|imex:IM-11563-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135679(gene)|ensembl:ENST00000539479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000258149|ensembl:ENSP00000258149|ensembl:ENST00000299252|ensembl:ENSP00000299252|ensembl:ENST00000360430|ensembl:ENSP00000353611|ensembl:ENST00000393413|ensembl:ENSP00000377065|ensembl:ENSP00000444430|refseq:NP_001138811.1|refseq:NP_001265391.1|refseq:NP_002383.2|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036369"(transcription factor catabolic process)|refseq:XP_005268929.1|refseq:XP_006719462.1|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|interpro:IPR044080|mint:Q00987|rcsb pdb:1RV1|rcsb pdb:1T4E|rcsb pdb:1T4F|rcsb pdb:1YCR|rcsb pdb:1Z1M|rcsb pdb:2AXI|rcsb pdb:2C6A|rcsb pdb:2C6B|rcsb pdb:2F1Y|rcsb pdb:2FOP|rcsb pdb:2GV2|rcsb pdb:2HDP|rcsb pdb:2LZG|rcsb pdb:2M86|rcsb pdb:2MPS|rcsb pdb:2RUH|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:3EQS|rcsb pdb:3G03|rcsb pdb:3IUX|rcsb pdb:3IWY|rcsb pdb:3JZK|rcsb pdb:3JZR|rcsb pdb:3JZS|rcsb pdb:3LBK|rcsb pdb:3LBL|rcsb pdb:3LNJ|rcsb pdb:3LNZ|rcsb pdb:3MQS|rcsb pdb:3TJ2|rcsb pdb:3TPX|rcsb pdb:3TU1|rcsb pdb:3V3B|rcsb pdb:3VBG|rcsb pdb:3VZV|rcsb pdb:3W69|rcsb pdb:4DIJ|rcsb pdb:4ERE|rcsb pdb:4ERF|rcsb pdb:4HBM|rcsb pdb:4HFZ|rcsb pdb:4HG7|rcsb pdb:4JV7|rcsb pdb:4JV9|rcsb pdb:4JVE|rcsb pdb:4JVR|rcsb pdb:4JWR|rcsb pdb:4MDN|rcsb pdb:4MDQ|rcsb pdb:4OAS|rcsb pdb:4OBA|rcsb pdb:4OCC|rcsb pdb:4ODE|rcsb pdb:4ODF|rcsb pdb:4OGN|rcsb pdb:4OGT|rcsb pdb:4OGV|rcsb pdb:4OQ3|rcsb pdb:4QO4|rcsb pdb:4QOC|rcsb pdb:4UD7|rcsb pdb:4UE1|rcsb pdb:4XXB|rcsb pdb:4ZFI|rcsb pdb:4ZGK|rcsb pdb:4ZYC|rcsb pdb:4ZYF|rcsb pdb:4ZYI|rcsb pdb:5AFG|rcsb pdb:5HMH|rcsb pdb:5HMI|rcsb pdb:5HMK|rcsb pdb:5J7F|rcsb pdb:5J7G|rcsb pdb:5LAV|rcsb pdb:5LAW|rcsb pdb:5C5A|rcsb pdb:5LAY|rcsb pdb:5LAZ|rcsb pdb:5LN2|rcsb pdb:5MNJ|rcsb pdb:5OAI|rcsb pdb:5OC8|rcsb pdb:5SWK|rcsb pdb:5TRF|rcsb pdb:5UMM|rcsb pdb:5VK0|rcsb pdb:5WTS|rcsb pdb:5XXK|rcsb pdb:5Z02|rcsb pdb:5ZXF|rcsb pdb:6AAW|rcsb pdb:6GGN|rcsb pdb:6H22|rcsb pdb:6HFA|rcsb pdb:6I29|rcsb pdb:6I3S|rcsb pdb:6IM9|rcsb pdb:6KZU|rcsb pdb:6Q96|rcsb pdb:6Q9H|rcsb pdb:6Q9L|rcsb pdb:6Q9O|rcsb pdb:6SQO|rcsb pdb:6T2D|rcsb pdb:6T2E|rcsb pdb:6T2F|rcsb pdb:6Y4Q|rcsb pdb:7AD0|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BIR|rcsb pdb:7BIT|rcsb pdb:7BIV|rcsb pdb:7BJ0|rcsb pdb:7BJ6|rcsb pdb:7BMG|reactome:R-HSA-198323|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-399719|reactome:R-HSA-5674400|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69541|reactome:R-HSA-8941858|rcsb pdb:4UMN|rcsb pdb:4WT2|dip:DIP-392N|mint:MINT-6540907(identity)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|mint:MINT-6540911(identity)	-	-	-	figure legend:F4D F4F F6D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2008/05/07	2014/10/16	rogid:CFy2L9Et1jFtlApOFn2AKiGPWJ89606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:8DE8B0014CD54511|rigid:dqcQ3QDCTDZxf8Q5dqA5O01HXZ8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0CG48	uniprotkb:P04637	intact:EBI-3390054|ensembl:ENSP00000344818|ensembl:ENSP00000441543|uniprotkb:Q9BWD6|uniprotkb:P02249|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q9UPK7|uniprotkb:P62988|uniprotkb:P02250|uniprotkb:Q9UEK8|uniprotkb:Q6LDU5|uniprotkb:Q91888|uniprotkb:Q6LBL4|uniprotkb:Q9UEF2|uniprotkb:Q29120|uniprotkb:P02248|uniprotkb:Q9BX98|uniprotkb:Q9UEG1	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:ubc_human(display_long)|uniprotkb:UBC(gene name)|psi-mi:UBC(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833559|mint:MINT-6541035|imex:IM-11563-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-1253288|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5656121|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5689880|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|reactome:R-HSA-983168|reactome:R-HSA-9613829|ensembl:ENSG00000150991(gene)|ensembl:ENST00000339647(transcript)|ensembl:ENST00000536769(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG48|rcsb pdb:1C3T|rcsb pdb:1CMX|rcsb pdb:1D3Z|rcsb pdb:1F9J|rcsb pdb:1FXT|rcsb pdb:1G6J|rcsb pdb:1GJZ|rcsb pdb:1NBF|rcsb pdb:1OGW|rcsb pdb:1Q5W|rcsb pdb:1S1Q|rcsb pdb:1SIF|rcsb pdb:1TBE|rcsb pdb:1UBI|rcsb pdb:1UBQ|rcsb pdb:1UD7|rcsb pdb:1XD3|rcsb pdb:1XQQ|rcsb pdb:1YX5|rcsb pdb:1YX6|rcsb pdb:1ZGU|rcsb pdb:1ZO6|rcsb pdb:2AYO|rcsb pdb:2BGF|rcsb pdb:2DEN|rcsb pdb:2FUH|rcsb pdb:2G45|rcsb pdb:2GBJ|rcsb pdb:2GBK|rcsb pdb:2GBM|rcsb pdb:2GBN|rcsb pdb:2GBR|rcsb pdb:2GMI|rcsb pdb:2HTH|rcsb pdb:2IBI|rcsb pdb:2J7Q|rcsb pdb:2JF5|rcsb pdb:2JRI|interpro:IPR000626(Ubiquitin)|rcsb pdb:2JY6|rcsb pdb:2JZZ|rcsb pdb:2K25|rcsb pdb:2K6D|rcsb pdb:2K8B|rcsb pdb:2K8C|rcsb pdb:2KDF|rcsb pdb:2KHW|rcsb pdb:2KJH|rcsb pdb:2KLG|rcsb pdb:2KN5|rcsb pdb:2KX0|rcsb pdb:2L3Z|rcsb pdb:2LD9|rcsb pdb:2LVO|rcsb pdb:2LVP|rcsb pdb:2LVQ|rcsb pdb:2LZ6|rcsb pdb:2MBO|rcsb pdb:2MBQ|rcsb pdb:2MCN|rcsb pdb:2MJ5|rcsb pdb:2MOR|rcsb pdb:2MRE|rcsb pdb:2MWS|rcsb pdb:2N2K|rcsb pdb:2NR2|rcsb pdb:2O6V|rcsb pdb:2OJR|rcsb pdb:2PE9|rcsb pdb:2PEA|rcsb pdb:2RR9|rcsb pdb:2RU6|rcsb pdb:2MI8|rcsb pdb:2W9N|rcsb pdb:2WDT|rcsb pdb:2XEW|rcsb pdb:2Y5B|rcsb pdb:2Z59|rcsb pdb:2ZCB|rcsb pdb:2ZVN|rcsb pdb:2ZVO|rcsb pdb:3A33|rcsb pdb:3ALB|rcsb pdb:3AUL|rcsb pdb:3B08|rcsb pdb:3B0A|rcsb pdb:3BY4|rcsb pdb:3C0R|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EEC|rcsb pdb:3EFU|rcsb pdb:3EHV|rcsb pdb:3H7P|rcsb pdb:3H7S|rcsb pdb:3HM3|rcsb pdb:3I3T|rcsb pdb:3IFW|rcsb pdb:3IHP|rcsb pdb:3JSV|rcsb pdb:3JVZ|rcsb pdb:3JW0|rcsb pdb:3K9O|rcsb pdb:3K9P|rcsb pdb:3KVF|rcsb pdb:3KW5|rcsb pdb:3LDZ|rcsb pdb:3MHS|rcsb pdb:3MTN|rcsb pdb:3N30|rcsb pdb:3N32|rcsb pdb:3N3K|rcsb pdb:3NS8|rcsb pdb:3O65|rcsb pdb:3OFI|rcsb pdb:3OJ3|rcsb pdb:3OJ4|rcsb pdb:3ONS|rcsb pdb:3PRM|rcsb pdb:3PT2|rcsb pdb:3Q3F|rcsb pdb:3RUL|rcsb pdb:3PTF|rcsb pdb:3TMP|rcsb pdb:3U30|rcsb pdb:3UGB|rcsb pdb:3V6C|rcsb pdb:3V6E|rcsb pdb:3VFK|rcsb pdb:3VUW|rcsb pdb:3VUX|rcsb pdb:3VUY|rcsb pdb:3WXE|rcsb pdb:3WXF|rcsb pdb:3ZLZ|rcsb pdb:3ZNH|rcsb pdb:3ZNI|rcsb pdb:3ZNZ|rcsb pdb:4AP4|rcsb pdb:4AUQ|rcsb pdb:4BOS|rcsb pdb:4BOZ|rcsb pdb:4BVU|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4FJV|rcsb pdb:4HK2|rcsb pdb:4HXD|rcsb pdb:4I6L|rcsb pdb:4I6N|rcsb pdb:4IG7|rcsb pdb:4IUM|rcsb pdb:4JQW|rcsb pdb:4K1R|rcsb pdb:4K7S|rcsb pdb:4K7U|rcsb pdb:4K7W|rcsb pdb:4KSK|rcsb pdb:4KSL|rcsb pdb:4LCD|rcsb pdb:4LDT|rcsb pdb:4MDK|rcsb pdb:4MM3|rcsb pdb:4MSM|rcsb pdb:4MSQ|rcsb pdb:4NQK|rcsb pdb:4UN2|rcsb pdb:4V3K|rcsb pdb:4V3L|rcsb pdb:4WZP|rcsb pdb:4XOK|rcsb pdb:4XOL|rcsb pdb:4ZQS|rcsb pdb:5A5B|rcsb pdb:5AF4|rcsb pdb:5AF5|rcsb pdb:5AF6|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5B83|rcsb pdb:5C7J|rcsb pdb:5C7M|rcsb pdb:5E6J|rcsb pdb:5H07|rcsb pdb:5NL4|rcsb pdb:5NLF|rcsb pdb:5NLI|rcsb pdb:5NMC|rcsb pdb:5OE7|rcsb pdb:5OHV|rcsb pdb:5OXH|rcsb pdb:5OXI|rcsb pdb:5UDH|rcsb pdb:5WQ4|rcsb pdb:5ZQ3|rcsb pdb:5ZQ4|rcsb pdb:5ZQ5|rcsb pdb:5ZQ6|rcsb pdb:5ZQ7|rcsb pdb:6A43|rcsb pdb:6A44|rcsb pdb:6AQR|rcsb pdb:6B7M|rcsb pdb:6B7O|rcsb pdb:6K2U|rcsb pdb:6KBE|rcsb pdb:6N13|rcsb pdb:6N6R|rcsb pdb:6NQA|rcsb pdb:6NXK|rcsb pdb:6OI4|rcsb pdb:6P5B|rcsb pdb:6Q00|rcsb pdb:6QML|rcsb pdb:6RYA|rcsb pdb:6S53|rcsb pdb:6SQR|rcsb pdb:6T7F|rcsb pdb:6T9L|rcsb pdb:6TNF|rcsb pdb:6TTU|rcsb pdb:6TUV|rcsb pdb:6TXB|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6EQI|rcsb pdb:6UMS|rcsb pdb:6UPU|rcsb pdb:6V5D|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:6VEN|rcsb pdb:6W9D|rcsb pdb:6W9R|rcsb pdb:6W9S|rcsb pdb:6WJD|rcsb pdb:6WKR|rcsb pdb:6WTG|rcsb pdb:6Z7V|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|rcsb pdb:7K6P|rcsb pdb:7K6Q|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|refseq:NP_066289.3|mint:MINT-6541037(identity)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|mint:MINT-6541041(identity)	-	-	-	figure legend:F5B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2008/05/07	2014/10/16	rogid:BM+LHQXjMaUn8RZfq1h9jsAAqcs9606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:8126E17DF61E2EC1|rigid:PB5tl8UphiFBM4mhlc3qZ7DRupo	false	ha tag:?-?(MINT-6541038)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q00987	uniprotkb:P04637	intact:EBI-389668|intact:EBI-28980679|ensembl:ENSP00000444430|uniprotkb:A6NL51|uniprotkb:Q13226|uniprotkb:Q13297|uniprotkb:Q13298|uniprotkb:Q13299|uniprotkb:Q13300|uniprotkb:Q13301|uniprotkb:Q53XW0|uniprotkb:Q71TW9|uniprotkb:Q8WYJ1|uniprotkb:Q8WYJ2|uniprotkb:Q9UGI3|uniprotkb:Q9UMT8|uniprotkb:A8K2S6	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:mdm2_human(display_long)|uniprotkb:MDM2(gene name)|psi-mi:MDM2(display_short)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833585|mint:MINT-6540920|imex:IM-11563-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135679(gene)|ensembl:ENST00000539479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000258149|ensembl:ENSP00000258149|ensembl:ENST00000299252|ensembl:ENSP00000299252|ensembl:ENST00000360430|ensembl:ENSP00000353611|ensembl:ENST00000393413|ensembl:ENSP00000377065|ensembl:ENSP00000444430|refseq:NP_001138811.1|refseq:NP_001265391.1|refseq:NP_002383.2|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036369"(transcription factor catabolic process)|refseq:XP_005268929.1|refseq:XP_006719462.1|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|interpro:IPR044080|mint:Q00987|rcsb pdb:1RV1|rcsb pdb:1T4E|rcsb pdb:1T4F|rcsb pdb:1YCR|rcsb pdb:1Z1M|rcsb pdb:2AXI|rcsb pdb:2C6A|rcsb pdb:2C6B|rcsb pdb:2F1Y|rcsb pdb:2FOP|rcsb pdb:2GV2|rcsb pdb:2HDP|rcsb pdb:2LZG|rcsb pdb:2M86|rcsb pdb:2MPS|rcsb pdb:2RUH|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:3EQS|rcsb pdb:3G03|rcsb pdb:3IUX|rcsb pdb:3IWY|rcsb pdb:3JZK|rcsb pdb:3JZR|rcsb pdb:3JZS|rcsb pdb:3LBK|rcsb pdb:3LBL|rcsb pdb:3LNJ|rcsb pdb:3LNZ|rcsb pdb:3MQS|rcsb pdb:3TJ2|rcsb pdb:3TPX|rcsb pdb:3TU1|rcsb pdb:3V3B|rcsb pdb:3VBG|rcsb pdb:3VZV|rcsb pdb:3W69|rcsb pdb:4DIJ|rcsb pdb:4ERE|rcsb pdb:4ERF|rcsb pdb:4HBM|rcsb pdb:4HFZ|rcsb pdb:4HG7|rcsb pdb:4JV7|rcsb pdb:4JV9|rcsb pdb:4JVE|rcsb pdb:4JVR|rcsb pdb:4JWR|rcsb pdb:4MDN|rcsb pdb:4MDQ|rcsb pdb:4OAS|rcsb pdb:4OBA|rcsb pdb:4OCC|rcsb pdb:4ODE|rcsb pdb:4ODF|rcsb pdb:4OGN|rcsb pdb:4OGT|rcsb pdb:4OGV|rcsb pdb:4OQ3|rcsb pdb:4QO4|rcsb pdb:4QOC|rcsb pdb:4UD7|rcsb pdb:4UE1|rcsb pdb:4XXB|rcsb pdb:4ZFI|rcsb pdb:4ZGK|rcsb pdb:4ZYC|rcsb pdb:4ZYF|rcsb pdb:4ZYI|rcsb pdb:5AFG|rcsb pdb:5HMH|rcsb pdb:5HMI|rcsb pdb:5HMK|rcsb pdb:5J7F|rcsb pdb:5J7G|rcsb pdb:5LAV|rcsb pdb:5LAW|rcsb pdb:5C5A|rcsb pdb:5LAY|rcsb pdb:5LAZ|rcsb pdb:5LN2|rcsb pdb:5MNJ|rcsb pdb:5OAI|rcsb pdb:5OC8|rcsb pdb:5SWK|rcsb pdb:5TRF|rcsb pdb:5UMM|rcsb pdb:5VK0|rcsb pdb:5WTS|rcsb pdb:5XXK|rcsb pdb:5Z02|rcsb pdb:5ZXF|rcsb pdb:6AAW|rcsb pdb:6GGN|rcsb pdb:6H22|rcsb pdb:6HFA|rcsb pdb:6I29|rcsb pdb:6I3S|rcsb pdb:6IM9|rcsb pdb:6KZU|rcsb pdb:6Q96|rcsb pdb:6Q9H|rcsb pdb:6Q9L|rcsb pdb:6Q9O|rcsb pdb:6SQO|rcsb pdb:6T2D|rcsb pdb:6T2E|rcsb pdb:6T2F|rcsb pdb:6Y4Q|rcsb pdb:7AD0|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BIR|rcsb pdb:7BIT|rcsb pdb:7BIV|rcsb pdb:7BJ0|rcsb pdb:7BJ6|rcsb pdb:7BMG|reactome:R-HSA-198323|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-399719|reactome:R-HSA-5674400|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69541|reactome:R-HSA-8941858|rcsb pdb:4UMN|rcsb pdb:4WT2|dip:DIP-392N|mint:MINT-6540922(identity)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|mint:MINT-6540924(identity)	-	-	-	figure legend:F4G|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/07	2014/10/16	rogid:CFy2L9Et1jFtlApOFn2AKiGPWJ89606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:432FE505538253E6|rigid:TaXqqLSzYzEOq7M/sUkK/LdrLVA	false	t7 tag:?-?(MINT-6540937)	ha tag:?-?(MINT-6540934)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q00987	uniprotkb:P61289	intact:EBI-389668|intact:EBI-28980679|ensembl:ENSP00000444430|uniprotkb:A6NL51|uniprotkb:Q13226|uniprotkb:Q13297|uniprotkb:Q13298|uniprotkb:Q13299|uniprotkb:Q13300|uniprotkb:Q13301|uniprotkb:Q53XW0|uniprotkb:Q71TW9|uniprotkb:Q8WYJ1|uniprotkb:Q8WYJ2|uniprotkb:Q9UGI3|uniprotkb:Q9UMT8|uniprotkb:A8K2S6	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	psi-mi:mdm2_human(display_long)|uniprotkb:MDM2(gene name)|psi-mi:MDM2(display_short)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Zhang et al. (2008)	pubmed:18309296|imex:IM-11563|mint:MINT-6540744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7833585|mint:MINT-6540920|imex:IM-11563-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135679(gene)|ensembl:ENST00000539479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000258149|ensembl:ENSP00000258149|ensembl:ENST00000299252|ensembl:ENSP00000299252|ensembl:ENST00000360430|ensembl:ENSP00000353611|ensembl:ENST00000393413|ensembl:ENSP00000377065|ensembl:ENSP00000444430|refseq:NP_001138811.1|refseq:NP_001265391.1|refseq:NP_002383.2|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036369"(transcription factor catabolic process)|refseq:XP_005268929.1|refseq:XP_006719462.1|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|interpro:IPR044080|mint:Q00987|rcsb pdb:1RV1|rcsb pdb:1T4E|rcsb pdb:1T4F|rcsb pdb:1YCR|rcsb pdb:1Z1M|rcsb pdb:2AXI|rcsb pdb:2C6A|rcsb pdb:2C6B|rcsb pdb:2F1Y|rcsb pdb:2FOP|rcsb pdb:2GV2|rcsb pdb:2HDP|rcsb pdb:2LZG|rcsb pdb:2M86|rcsb pdb:2MPS|rcsb pdb:2RUH|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:3EQS|rcsb pdb:3G03|rcsb pdb:3IUX|rcsb pdb:3IWY|rcsb pdb:3JZK|rcsb pdb:3JZR|rcsb pdb:3JZS|rcsb pdb:3LBK|rcsb pdb:3LBL|rcsb pdb:3LNJ|rcsb pdb:3LNZ|rcsb pdb:3MQS|rcsb pdb:3TJ2|rcsb pdb:3TPX|rcsb pdb:3TU1|rcsb pdb:3V3B|rcsb pdb:3VBG|rcsb pdb:3VZV|rcsb pdb:3W69|rcsb pdb:4DIJ|rcsb pdb:4ERE|rcsb pdb:4ERF|rcsb pdb:4HBM|rcsb pdb:4HFZ|rcsb pdb:4HG7|rcsb pdb:4JV7|rcsb pdb:4JV9|rcsb pdb:4JVE|rcsb pdb:4JVR|rcsb pdb:4JWR|rcsb pdb:4MDN|rcsb pdb:4MDQ|rcsb pdb:4OAS|rcsb pdb:4OBA|rcsb pdb:4OCC|rcsb pdb:4ODE|rcsb pdb:4ODF|rcsb pdb:4OGN|rcsb pdb:4OGT|rcsb pdb:4OGV|rcsb pdb:4OQ3|rcsb pdb:4QO4|rcsb pdb:4QOC|rcsb pdb:4UD7|rcsb pdb:4UE1|rcsb pdb:4XXB|rcsb pdb:4ZFI|rcsb pdb:4ZGK|rcsb pdb:4ZYC|rcsb pdb:4ZYF|rcsb pdb:4ZYI|rcsb pdb:5AFG|rcsb pdb:5HMH|rcsb pdb:5HMI|rcsb pdb:5HMK|rcsb pdb:5J7F|rcsb pdb:5J7G|rcsb pdb:5LAV|rcsb pdb:5LAW|rcsb pdb:5C5A|rcsb pdb:5LAY|rcsb pdb:5LAZ|rcsb pdb:5LN2|rcsb pdb:5MNJ|rcsb pdb:5OAI|rcsb pdb:5OC8|rcsb pdb:5SWK|rcsb pdb:5TRF|rcsb pdb:5UMM|rcsb pdb:5VK0|rcsb pdb:5WTS|rcsb pdb:5XXK|rcsb pdb:5Z02|rcsb pdb:5ZXF|rcsb pdb:6AAW|rcsb pdb:6GGN|rcsb pdb:6H22|rcsb pdb:6HFA|rcsb pdb:6I29|rcsb pdb:6I3S|rcsb pdb:6IM9|rcsb pdb:6KZU|rcsb pdb:6Q96|rcsb pdb:6Q9H|rcsb pdb:6Q9L|rcsb pdb:6Q9O|rcsb pdb:6SQO|rcsb pdb:6T2D|rcsb pdb:6T2E|rcsb pdb:6T2F|rcsb pdb:6Y4Q|rcsb pdb:7AD0|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BIR|rcsb pdb:7BIT|rcsb pdb:7BIV|rcsb pdb:7BJ0|rcsb pdb:7BJ6|rcsb pdb:7BMG|reactome:R-HSA-198323|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-399719|reactome:R-HSA-5674400|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69541|reactome:R-HSA-8941858|rcsb pdb:4UMN|rcsb pdb:4WT2|dip:DIP-392N|mint:MINT-6540922(identity)	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|mint:MINT-6540926(identity)	-	-	-	figure legend:F4G|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/07	2014/10/16	rogid:CFy2L9Et1jFtlApOFn2AKiGPWJ89606	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	intact-crc:432FE505538253E6|rigid:TaXqqLSzYzEOq7M/sUkK/LdrLVA	false	t7 tag:?-?(MINT-6540937)	green fluorescent protein tag:?-?(MINT-6540931)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)