#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P61224	uniprotkb:P47736	intact:EBI-358143|intact:EBI-1047928|uniprotkb:P09526|uniprotkb:Q6DCA1|uniprotkb:Q6LES0|uniprotkb:Q502X3|uniprotkb:Q5TZR4|uniprotkb:B2R5Z2|intact:EBI-11037134|uniprotkb:B4DQI8|uniprotkb:B4DW74|uniprotkb:B4DW94|ensembl:ENSP00000250559|ensembl:ENSP00000377085|ensembl:ENSP00000439966|ensembl:ENSP00000441275	intact:EBI-722307|uniprotkb:O75062|uniprotkb:Q5T3S9|uniprotkb:Q9UQ51|uniprotkb:Q5T3T4|uniprotkb:J3QSS6|uniprotkb:Q7Z5S8|ensembl:ENSP00000363897	psi-mi:rap1b_human(display_long)|uniprotkb:OK/SW-cl.11(orf name)|uniprotkb:RAP1B(gene name)|psi-mi:RAP1B(display_short)|uniprotkb:GTP-binding protein smg p21B(gene name synonym)	psi-mi:rpgp1_human(display_long)|uniprotkb:KIAA0474(gene name synonym)|uniprotkb:RAP1GAP(gene name)|psi-mi:RAP1GAP(display_short)|uniprotkb:RAP1GA1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Scrima et al. (2008)	pubmed:18309292|imex:IM-11578|mint:MINT-6543607	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7823893|mint:MINT-6543614|imex:IM-11578-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001010942.1|refseq:NP_056461.1|dip:DIP-35407N|refseq:NP_001238846.1|refseq:NP_001238847.1|refseq:NP_001238850.1|refseq:NP_001238851.1|ensembl:ENSG00000127314(gene)|ensembl:ENST00000250559(transcript)|ensembl:ENST00000341355(transcript)|ensembl:ENST00000393436(transcript)|ensembl:ENST00000537460(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035690"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097211"(cellular response to gonadotropin-releasing hormone)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|mint:P61224|rcsb pdb:3BRW|rcsb pdb:3CF6|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4M8N|rcsb pdb:4MGI|rcsb pdb:4MGK|rcsb pdb:4MGY|rcsb pdb:4MGZ|rcsb pdb:4MH0|rcsb pdb:5KHO|rcsb pdb:6AXF|rcsb pdb:6BA6|rcsb pdb:6KYK|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-392517|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8875555|reactome:R-HSA-8950505|reactome:R-HSA-9649948|reactome:R-HSA-9656223|mint:MINT-6543616(identity)	refseq:NP_001139129.1|refseq:NP_002876.2|refseq:NP_001139130.1|refseq:XP_005246012.2|refseq:XP_016857459.1|refseq:XP_016857462.1|refseq:XP_016857473.1|refseq:XP_016857475.1|refseq:XP_016857476.1|refseq:XP_016857477.1|ensembl:ENSG00000076864(gene)|ensembl:ENST00000374765(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1903697"(negative regulation of microvillus assembly)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:1904442"(negative regulation of thyroid gland epithelial cell proliferation)|go:"GO:1990792"(cellular response to glial cell derived neurotrophic factor)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003109(GoLoco)|interpro:IPR035974|mint:P47736|rcsb pdb:1SRQ|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|reactome:R-HSA-392517|reactome:R-HSA-8853659|rcsb pdb:3BRW|mint:MINT-6543617(identity)	-	-	-	figure legend:F1 T1|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/19	2014/10/16	rogid:CiuN7je+CaRH9QKDiR3vrzcJ87g9606	rogid:bvcigCfiV//wfZJOxaeQm17r3F49606	intact-crc:2A238F9B02797109|rigid:fB+jNfpg0HXS2gry/8VV5FheAiI	false	binding-associated region:1-167(MINT-6543621)	binding-associated region:75-415(MINT-6543626)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61224	uniprotkb:P47736	intact:EBI-358143|intact:EBI-1047928|uniprotkb:P09526|uniprotkb:Q6DCA1|uniprotkb:Q6LES0|uniprotkb:Q502X3|uniprotkb:Q5TZR4|uniprotkb:B2R5Z2|intact:EBI-11037134|uniprotkb:B4DQI8|uniprotkb:B4DW74|uniprotkb:B4DW94|ensembl:ENSP00000250559|ensembl:ENSP00000377085|ensembl:ENSP00000439966|ensembl:ENSP00000441275	intact:EBI-722307|uniprotkb:O75062|uniprotkb:Q5T3S9|uniprotkb:Q9UQ51|uniprotkb:Q5T3T4|uniprotkb:J3QSS6|uniprotkb:Q7Z5S8|ensembl:ENSP00000363897	psi-mi:rap1b_human(display_long)|uniprotkb:OK/SW-cl.11(orf name)|uniprotkb:RAP1B(gene name)|psi-mi:RAP1B(display_short)|uniprotkb:GTP-binding protein smg p21B(gene name synonym)	psi-mi:rpgp1_human(display_long)|uniprotkb:KIAA0474(gene name synonym)|uniprotkb:RAP1GAP(gene name)|psi-mi:RAP1GAP(display_short)|uniprotkb:RAP1GA1(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Scrima et al. (2008)	pubmed:18309292|imex:IM-11578|mint:MINT-6543607	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7823924|mint:MINT-6543629|imex:IM-11578-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001010942.1|refseq:NP_056461.1|dip:DIP-35407N|refseq:NP_001238846.1|refseq:NP_001238847.1|refseq:NP_001238850.1|refseq:NP_001238851.1|ensembl:ENSG00000127314(gene)|ensembl:ENST00000250559(transcript)|ensembl:ENST00000341355(transcript)|ensembl:ENST00000393436(transcript)|ensembl:ENST00000537460(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035690"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097211"(cellular response to gonadotropin-releasing hormone)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|mint:P61224|rcsb pdb:3BRW|rcsb pdb:3CF6|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4M8N|rcsb pdb:4MGI|rcsb pdb:4MGK|rcsb pdb:4MGY|rcsb pdb:4MGZ|rcsb pdb:4MH0|rcsb pdb:5KHO|rcsb pdb:6AXF|rcsb pdb:6BA6|rcsb pdb:6KYK|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-392517|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8875555|reactome:R-HSA-8950505|reactome:R-HSA-9649948|reactome:R-HSA-9656223|mint:MINT-6543635(identity)	refseq:NP_001139129.1|refseq:NP_002876.2|refseq:NP_001139130.1|refseq:XP_005246012.2|refseq:XP_016857459.1|refseq:XP_016857462.1|refseq:XP_016857473.1|refseq:XP_016857475.1|refseq:XP_016857476.1|refseq:XP_016857477.1|ensembl:ENSG00000076864(gene)|ensembl:ENST00000374765(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1903697"(negative regulation of microvillus assembly)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:1904442"(negative regulation of thyroid gland epithelial cell proliferation)|go:"GO:1990792"(cellular response to glial cell derived neurotrophic factor)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003109(GoLoco)|interpro:IPR035974|mint:P47736|rcsb pdb:1SRQ|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|reactome:R-HSA-392517|reactome:R-HSA-8853659|rcsb pdb:3BRW|mint:MINT-6543631(identity)	-	-	-	figure legend:F1G|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/19	2014/10/16	rogid:CiuN7je+CaRH9QKDiR3vrzcJ87g9606	rogid:bvcigCfiV//wfZJOxaeQm17r3F49606	intact-crc:CEF3A495BCEDFAB6|rigid:fB+jNfpg0HXS2gry/8VV5FheAiI	false	binding-associated region:1-167(MINT-6543636)|mutation disrupting interaction:63-63(MINT-6543646)	binding-associated region:75-415(MINT-6543632)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61224	uniprotkb:P47736	intact:EBI-358143|intact:EBI-1047928|uniprotkb:P09526|uniprotkb:Q6DCA1|uniprotkb:Q6LES0|uniprotkb:Q502X3|uniprotkb:Q5TZR4|uniprotkb:B2R5Z2|intact:EBI-11037134|uniprotkb:B4DQI8|uniprotkb:B4DW74|uniprotkb:B4DW94|ensembl:ENSP00000250559|ensembl:ENSP00000377085|ensembl:ENSP00000439966|ensembl:ENSP00000441275	intact:EBI-722307|uniprotkb:O75062|uniprotkb:Q5T3S9|uniprotkb:Q9UQ51|uniprotkb:Q5T3T4|uniprotkb:J3QSS6|uniprotkb:Q7Z5S8|ensembl:ENSP00000363897	psi-mi:rap1b_human(display_long)|uniprotkb:OK/SW-cl.11(orf name)|uniprotkb:RAP1B(gene name)|psi-mi:RAP1B(display_short)|uniprotkb:GTP-binding protein smg p21B(gene name synonym)	psi-mi:rpgp1_human(display_long)|uniprotkb:KIAA0474(gene name synonym)|uniprotkb:RAP1GAP(gene name)|psi-mi:RAP1GAP(display_short)|uniprotkb:RAP1GA1(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Scrima et al. (2008)	pubmed:18309292|imex:IM-11578|mint:MINT-6543607	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7823949|mint:MINT-6543650|imex:IM-11578-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001010942.1|refseq:NP_056461.1|dip:DIP-35407N|refseq:NP_001238846.1|refseq:NP_001238847.1|refseq:NP_001238850.1|refseq:NP_001238851.1|ensembl:ENSG00000127314(gene)|ensembl:ENST00000250559(transcript)|ensembl:ENST00000341355(transcript)|ensembl:ENST00000393436(transcript)|ensembl:ENST00000537460(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035690"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097211"(cellular response to gonadotropin-releasing hormone)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|mint:P61224|rcsb pdb:3BRW|rcsb pdb:3CF6|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4M8N|rcsb pdb:4MGI|rcsb pdb:4MGK|rcsb pdb:4MGY|rcsb pdb:4MGZ|rcsb pdb:4MH0|rcsb pdb:5KHO|rcsb pdb:6AXF|rcsb pdb:6BA6|rcsb pdb:6KYK|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-392517|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8875555|reactome:R-HSA-8950505|reactome:R-HSA-9649948|reactome:R-HSA-9656223|mint:MINT-6543652(identity)	refseq:NP_001139129.1|refseq:NP_002876.2|refseq:NP_001139130.1|refseq:XP_005246012.2|refseq:XP_016857459.1|refseq:XP_016857462.1|refseq:XP_016857473.1|refseq:XP_016857475.1|refseq:XP_016857476.1|refseq:XP_016857477.1|ensembl:ENSG00000076864(gene)|ensembl:ENST00000374765(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1903697"(negative regulation of microvillus assembly)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:1904442"(negative regulation of thyroid gland epithelial cell proliferation)|go:"GO:1990792"(cellular response to glial cell derived neurotrophic factor)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003109(GoLoco)|interpro:IPR035974|mint:P47736|rcsb pdb:1SRQ|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|reactome:R-HSA-392517|reactome:R-HSA-8853659|rcsb pdb:3BRW|mint:MINT-6543658(identity)	-	-	-	figure legend:F1G|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/19	2014/10/16	rogid:CiuN7je+CaRH9QKDiR3vrzcJ87g9606	rogid:bvcigCfiV//wfZJOxaeQm17r3F49606	intact-crc:3210C379EB86C37E|rigid:fB+jNfpg0HXS2gry/8VV5FheAiI	false	mutation disrupting interaction:64-64(MINT-6543653)|binding-associated region:1-167(MINT-6543655)	binding-associated region:75-415(MINT-6543659)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)