#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04133	uniprotkb:P00742	intact:EBI-1646019	intact:EBI-719750|uniprotkb:Q14340|ensembl:ENSP00000364709	psi-mi:capsh_ade05(display_long)|uniprotkb:L3(gene name)|psi-mi:L3(display_short)|uniprotkb:Protein II(gene name synonym)	psi-mi:fa10_human(display_long)|uniprotkb:Stuart factor(gene name synonym)|uniprotkb:Stuart-Prower factor(gene name synonym)|uniprotkb:F10(gene name)|psi-mi:F10(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Waddington et al. (2008)	imex:IM-12027|pubmed:18267072|mint:MINT-6594495	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1646042|imex:IM-12027-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR016108(Major coat protein hexon, C-terminal, Adenovirus)|interpro:IPR016107(Major coat protein hexon, N-terminal, Adenovirus)|interpro:IPR016112(Major coat protein hexon/vp54/p3, dsDNA virus)|refseq:AP_000211.1|rcsb pdb:1P30|rcsb pdb:4V4U|rcsb pdb:3TG7|rcsb pdb:5OGI|rcsb pdb:6EQC|rcsb pdb:5LDN|rcsb pdb:6B1T|interpro:IPR037542|rcsb pdb:6CGV|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0039623"(T=25 icosahedral viral capsid)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075521"(microtubule-dependent intracellular transport of viral material towards nucleus)	refseq:NP_000495.1|ensembl:ENSG00000126218(gene)|ensembl:ENST00000375559(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031233"(intrinsic component of external side of plasma membrane)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012224(Peptidase S1A, coagulation factor VII/IX/X/C/Z)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR035972|interpro:IPR043504|mint:P00742|rcsb pdb:1C5M|rcsb pdb:1EZQ|rcsb pdb:1F0R|rcsb pdb:1F0S|rcsb pdb:1FAX|rcsb pdb:1FJS|rcsb pdb:1FXY|rcsb pdb:1G2L|rcsb pdb:1G2M|rcsb pdb:1HCG|rcsb pdb:1IOE|rcsb pdb:1IQE|rcsb pdb:1IQF|rcsb pdb:1IQG|rcsb pdb:1IQH|rcsb pdb:1IQI|rcsb pdb:1IQJ|rcsb pdb:1IQK|rcsb pdb:1IQL|rcsb pdb:1IQM|rcsb pdb:1IQN|rcsb pdb:1KSN|rcsb pdb:1LPG|rcsb pdb:1LPK|rcsb pdb:1LPZ|rcsb pdb:1LQD|rcsb pdb:1MQ5|rcsb pdb:1MQ6|rcsb pdb:1MSX|rcsb pdb:1NFU|rcsb pdb:1NFW|rcsb pdb:1NFX|rcsb pdb:1NFY|rcsb pdb:1NL8|rcsb pdb:1P0S|rcsb pdb:1V3X|rcsb pdb:1WU1|rcsb pdb:1XKA|rcsb pdb:1XKB|rcsb pdb:1Z6E|rcsb pdb:2BMG|rcsb pdb:2BOH|rcsb pdb:2BOK|rcsb pdb:2BQ6|rcsb pdb:2BQ7|rcsb pdb:2BQW|rcsb pdb:2CJI|rcsb pdb:2D1J|rcsb pdb:2EI6|rcsb pdb:2EI7|rcsb pdb:2EI8|rcsb pdb:2FZZ|rcsb pdb:2G00|rcsb pdb:2GD4|rcsb pdb:2H9E|rcsb pdb:2J2U|rcsb pdb:2J34|rcsb pdb:2J38|rcsb pdb:2J4I|rcsb pdb:2J94|rcsb pdb:2J95|rcsb pdb:2P16|rcsb pdb:2P3F|rcsb pdb:2P3T|rcsb pdb:2P3U|rcsb pdb:2P93|rcsb pdb:2P94|rcsb pdb:2P95|rcsb pdb:2PHB|rcsb pdb:2PR3|rcsb pdb:2Q1J|rcsb pdb:2RA0|rcsb pdb:2UWL|rcsb pdb:2UWO|rcsb pdb:2UWP|rcsb pdb:2VH0|rcsb pdb:2VH6|rcsb pdb:2VVC|rcsb pdb:2VVU|rcsb pdb:2VVV|rcsb pdb:2VWL|rcsb pdb:2VWM|rcsb pdb:2VWN|rcsb pdb:2VWO|rcsb pdb:2W26|rcsb pdb:2W3I|rcsb pdb:2W3K|rcsb pdb:2WYG|rcsb pdb:2WYJ|rcsb pdb:2XBV|rcsb pdb:2XBW|rcsb pdb:2XBX|rcsb pdb:2XBY|rcsb pdb:2XC0|rcsb pdb:2JKH|rcsb pdb:2XC4|rcsb pdb:2XC5|rcsb pdb:2Y5F|rcsb pdb:2Y5G|rcsb pdb:2Y5H|rcsb pdb:2Y7X|rcsb pdb:2Y7Z|rcsb pdb:2Y80|rcsb pdb:2Y81|rcsb pdb:2Y82|rcsb pdb:3CEN|rcsb pdb:3CS7|rcsb pdb:3ENS|rcsb pdb:3FFG|rcsb pdb:3HPT|rcsb pdb:3IIT|rcsb pdb:3K9X|rcsb pdb:3KL6|rcsb pdb:3KQB|rcsb pdb:3KQC|rcsb pdb:3KQD|rcsb pdb:3KQE|rcsb pdb:3LIW|rcsb pdb:3M36|rcsb pdb:3M37|rcsb pdb:3Q3K|rcsb pdb:3SW2|rcsb pdb:3TK6|rcsb pdb:4A7I|rcsb pdb:4BTI|rcsb pdb:4BTT|rcsb pdb:4BTU|rcsb pdb:4Y6D|rcsb pdb:4Y71|rcsb pdb:4Y76|rcsb pdb:4Y79|rcsb pdb:4Y7A|rcsb pdb:4Y7B|rcsb pdb:4ZH8|rcsb pdb:4ZHA|rcsb pdb:5JQY|rcsb pdb:5JTC|rcsb pdb:5JZ8|rcsb pdb:5JZU|rcsb pdb:5K0H|rcsb pdb:5VOE|rcsb pdb:5VOF|rcsb pdb:6Q9F|rcsb pdb:6Q9I|rcsb pdb:6RK9|rcsb pdb:6YYW|rcsb pdb:6YYX|rcsb pdb:6YYY|rcsb pdb:6Z6Q|rcsb pdb:6Z6R|rcsb pdb:7BMI|rcsb pdb:7BMJ|rcsb pdb:7E6J|rcsb pdb:3TK5|reactome:R-HSA-140834|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-9672383|reactome:R-HSA-9672396|reactome:R-HSA-9673202|refseq:NP_001299603.1|refseq:NP_001299604.1|dip:DIP-29896N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2D, Supp. Fig. 6|delivery method:P04133 purified|kinetics:"Association rate constant = 2.28E6 (1/Ms), dissociation rate constant = 4.5E-3 (1/s)"|comment:Interaction was calcium-dependent.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/06	2014/10/16	rogid:zj/Yo8JQiNz+1Pn/Vqgym2pK39A28285	rogid:EiG38fLKwrbGJftF5k4xjLvlYhA9606	intact-crc:60975CF84A22951E|rigid:xIT9ZnOTOkqo70wBUh8cvuTdxdM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08709	uniprotkb:P04133	intact:EBI-355972|ensembl:ENSP00000364731|uniprotkb:Q14339|uniprotkb:Q5JVF2|uniprotkb:B0YJC8|uniprotkb:Q5JVF1|uniprotkb:Q9UD52|uniprotkb:Q9UD53|uniprotkb:Q9UD54	intact:EBI-1646019	psi-mi:fa7_human(display_long)|uniprotkb:F7(gene name)|psi-mi:F7(display_short)|uniprotkb:Serum prothrombin conversion accelerator(gene name synonym)|uniprotkb:Proconvertin(gene name synonym)	psi-mi:capsh_ade05(display_long)|uniprotkb:L3(gene name)|psi-mi:L3(display_short)|uniprotkb:Protein II(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Waddington et al. (2008)	imex:IM-12027|pubmed:18267072|mint:MINT-6594495	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1646262|imex:IM-12027-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000057593(gene)|ensembl:ENST00000375581(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0010037"(response to carbon dioxide)|go:"GO:0010641"(positive regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016485"(protein processing)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032571"(response to vitamin K)|go:"GO:0033595"(response to genistein)|go:"GO:0043627"(response to estrogen)|rcsb pdb:1F7M|rcsb pdb:1FAK|rcsb pdb:1FF7|go:"GO:0050927"(positive regulation of positive chemotaxis)|rcsb pdb:1FFM|rcsb pdb:1J9C|rcsb pdb:1JBU|go:"GO:0051897"(positive regulation of protein kinase B signaling)|rcsb pdb:1KLI|go:"GO:0060416"(response to growth hormone)|go:"GO:0061476"(response to anticoagulant)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070723"(response to cholesterol)|go:"GO:0097068"(response to thyroxine)|go:"GO:1904400"(response to Thyroid stimulating hormone)|go:"GO:1904612"(response to 2,3,7,8-tetrachlorodibenzodioxine)|go:"GO:1905217"(response to astaxanthin)|go:"GO:1905225"(response to thyrotropin-releasing hormone)|go:"GO:1905286"(serine-type peptidase complex)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012224(Peptidase S1A, coagulation factor VII/IX/X/C/Z)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR033190|interpro:IPR035972|interpro:IPR043504|rcsb pdb:1BF9|rcsb pdb:1CVW|rcsb pdb:1DAN|rcsb pdb:1DVA|rcsb pdb:1F7E|rcsb pdb:1KLJ|rcsb pdb:1NL8|rcsb pdb:1O5D|rcsb pdb:1QFK|rcsb pdb:1W0Y|rcsb pdb:1W2K|rcsb pdb:1W7X|rcsb pdb:1W8B|rcsb pdb:1WQV|rcsb pdb:1WSS|rcsb pdb:1WTG|rcsb pdb:1WUN|rcsb pdb:1WV7|rcsb pdb:1YGC|rcsb pdb:1Z6J|rcsb pdb:2A2Q|rcsb pdb:2AEI|rcsb pdb:2AER|rcsb pdb:2B7D|rcsb pdb:2B8O|rcsb pdb:2BZ6|rcsb pdb:2C4F|rcsb pdb:2EC9|rcsb pdb:2F9B|rcsb pdb:2FIR|rcsb pdb:2FLB|rcsb pdb:2FLR|rcsb pdb:2PUQ|refseq:NP_000122.1|refseq:NP_062562.1|rcsb pdb:2ZP0|rcsb pdb:2ZWL|rcsb pdb:2ZZU|rcsb pdb:3ELA|rcsb pdb:3TH2|rcsb pdb:3TH3|rcsb pdb:3TH4|rcsb pdb:4IBL|rcsb pdb:4ISH|rcsb pdb:4ISI|rcsb pdb:4JYU|rcsb pdb:4JYV|rcsb pdb:4JZD|rcsb pdb:4JZE|rcsb pdb:4JZF|rcsb pdb:4NA9|rcsb pdb:4NG9|rcsb pdb:4NGA|rcsb pdb:4X8S|rcsb pdb:4X8T|rcsb pdb:4X8U|rcsb pdb:4X8V|rcsb pdb:4YLQ|rcsb pdb:4YT6|rcsb pdb:4YT7|rcsb pdb:4Z6A|rcsb pdb:4ZMA|rcsb pdb:4ZXX|rcsb pdb:4ZXY|rcsb pdb:5I46|rcsb pdb:5L0S|rcsb pdb:5L2Y|rcsb pdb:5L2Z|rcsb pdb:5L30|rcsb pdb:5PA8|rcsb pdb:5PA9|rcsb pdb:5PAA|rcsb pdb:5PAB|rcsb pdb:5PAC|rcsb pdb:5PAE|rcsb pdb:5PAF|rcsb pdb:5PAG|rcsb pdb:5PAI|rcsb pdb:5PAJ|rcsb pdb:5PAK|rcsb pdb:5PAM|rcsb pdb:5PAN|rcsb pdb:5PAO|rcsb pdb:5PAQ|rcsb pdb:5PAR|rcsb pdb:5PAS|rcsb pdb:5PAT|rcsb pdb:5PAU|rcsb pdb:5PAV|rcsb pdb:5PAW|rcsb pdb:5PAX|rcsb pdb:5PAY|rcsb pdb:5PB0|rcsb pdb:5PB1|rcsb pdb:5PB2|rcsb pdb:5PB3|rcsb pdb:5PB4|rcsb pdb:5PB5|rcsb pdb:5PB6|rcsb pdb:5TQE|rcsb pdb:5TQF|rcsb pdb:5TQG|rcsb pdb:5U6J|reactome:R-HSA-1368108|reactome:R-HSA-140834|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|dip:DIP-6135N	interpro:IPR016108(Major coat protein hexon, C-terminal, Adenovirus)|interpro:IPR016107(Major coat protein hexon, N-terminal, Adenovirus)|interpro:IPR016112(Major coat protein hexon/vp54/p3, dsDNA virus)|refseq:AP_000211.1|rcsb pdb:1P30|rcsb pdb:4V4U|rcsb pdb:3TG7|rcsb pdb:5OGI|rcsb pdb:6EQC|rcsb pdb:5LDN|rcsb pdb:6B1T|interpro:IPR037542|rcsb pdb:6CGV|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0039623"(T=25 icosahedral viral capsid)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075521"(microtubule-dependent intracellular transport of viral material towards nucleus)	go:"GO:0044403"(biological process involved in symbiotic interaction)	-	-	figure legend:Supp. Fig. 6|delivery method:P04133 purified|comment:Interaction was calcium dependent.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/06	2014/10/16	rogid:3AajTD0zonhwhwLyNtQ1rIKrgRI9606	rogid:zj/Yo8JQiNz+1Pn/Vqgym2pK39A28285	intact-crc:846B4F5184DB0D7F|rigid:q4X4CQXMkEzqB1UauZ8ztrlOnhw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16938	uniprotkb:P00742	intact:EBI-1646299	intact:EBI-719750|uniprotkb:Q14340|ensembl:ENSP00000364709	psi-mi:q16938_ancca(display_long)	psi-mi:fa10_human(display_long)|uniprotkb:Stuart factor(gene name synonym)|uniprotkb:Stuart-Prower factor(gene name synonym)|uniprotkb:F10(gene name)|psi-mi:F10(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Waddington et al. (2008)	imex:IM-12027|pubmed:18267072|mint:MINT-6594495	taxid:29170(ancca)|taxid:29170("Ancylostoma caninum (Dog hookworm)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1646305|imex:IM-12027-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002919(Protease inhibitor I8, cysteine-rich trypsin inhibitor-like)|rcsb pdb:1COU|rcsb pdb:2H9E|interpro:IPR036084|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)	refseq:NP_000495.1|ensembl:ENSG00000126218(gene)|ensembl:ENST00000375559(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031233"(intrinsic component of external side of plasma membrane)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012224(Peptidase S1A, coagulation factor VII/IX/X/C/Z)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR035972|interpro:IPR043504|mint:P00742|rcsb pdb:1C5M|rcsb pdb:1EZQ|rcsb pdb:1F0R|rcsb pdb:1F0S|rcsb pdb:1FAX|rcsb pdb:1FJS|rcsb pdb:1FXY|rcsb pdb:1G2L|rcsb pdb:1G2M|rcsb pdb:1HCG|rcsb pdb:1IOE|rcsb pdb:1IQE|rcsb pdb:1IQF|rcsb pdb:1IQG|rcsb pdb:1IQH|rcsb pdb:1IQI|rcsb pdb:1IQJ|rcsb pdb:1IQK|rcsb pdb:1IQL|rcsb pdb:1IQM|rcsb pdb:1IQN|rcsb pdb:1KSN|rcsb pdb:1LPG|rcsb pdb:1LPK|rcsb pdb:1LPZ|rcsb pdb:1LQD|rcsb pdb:1MQ5|rcsb pdb:1MQ6|rcsb pdb:1MSX|rcsb pdb:1NFU|rcsb pdb:1NFW|rcsb pdb:1NFX|rcsb pdb:1NFY|rcsb pdb:1NL8|rcsb pdb:1P0S|rcsb pdb:1V3X|rcsb pdb:1WU1|rcsb pdb:1XKA|rcsb pdb:1XKB|rcsb pdb:1Z6E|rcsb pdb:2BMG|rcsb pdb:2BOH|rcsb pdb:2BOK|rcsb pdb:2BQ6|rcsb pdb:2BQ7|rcsb pdb:2BQW|rcsb pdb:2CJI|rcsb pdb:2D1J|rcsb pdb:2EI6|rcsb pdb:2EI7|rcsb pdb:2EI8|rcsb pdb:2FZZ|rcsb pdb:2G00|rcsb pdb:2GD4|rcsb pdb:2H9E|rcsb pdb:2J2U|rcsb pdb:2J34|rcsb pdb:2J38|rcsb pdb:2J4I|rcsb pdb:2J94|rcsb pdb:2J95|rcsb pdb:2P16|rcsb pdb:2P3F|rcsb pdb:2P3T|rcsb pdb:2P3U|rcsb pdb:2P93|rcsb pdb:2P94|rcsb pdb:2P95|rcsb pdb:2PHB|rcsb pdb:2PR3|rcsb pdb:2Q1J|rcsb pdb:2RA0|rcsb pdb:2UWL|rcsb pdb:2UWO|rcsb pdb:2UWP|rcsb pdb:2VH0|rcsb pdb:2VH6|rcsb pdb:2VVC|rcsb pdb:2VVU|rcsb pdb:2VVV|rcsb pdb:2VWL|rcsb pdb:2VWM|rcsb pdb:2VWN|rcsb pdb:2VWO|rcsb pdb:2W26|rcsb pdb:2W3I|rcsb pdb:2W3K|rcsb pdb:2WYG|rcsb pdb:2WYJ|rcsb pdb:2XBV|rcsb pdb:2XBW|rcsb pdb:2XBX|rcsb pdb:2XBY|rcsb pdb:2XC0|rcsb pdb:2JKH|rcsb pdb:2XC4|rcsb pdb:2XC5|rcsb pdb:2Y5F|rcsb pdb:2Y5G|rcsb pdb:2Y5H|rcsb pdb:2Y7X|rcsb pdb:2Y7Z|rcsb pdb:2Y80|rcsb pdb:2Y81|rcsb pdb:2Y82|rcsb pdb:3CEN|rcsb pdb:3CS7|rcsb pdb:3ENS|rcsb pdb:3FFG|rcsb pdb:3HPT|rcsb pdb:3IIT|rcsb pdb:3K9X|rcsb pdb:3KL6|rcsb pdb:3KQB|rcsb pdb:3KQC|rcsb pdb:3KQD|rcsb pdb:3KQE|rcsb pdb:3LIW|rcsb pdb:3M36|rcsb pdb:3M37|rcsb pdb:3Q3K|rcsb pdb:3SW2|rcsb pdb:3TK6|rcsb pdb:4A7I|rcsb pdb:4BTI|rcsb pdb:4BTT|rcsb pdb:4BTU|rcsb pdb:4Y6D|rcsb pdb:4Y71|rcsb pdb:4Y76|rcsb pdb:4Y79|rcsb pdb:4Y7A|rcsb pdb:4Y7B|rcsb pdb:4ZH8|rcsb pdb:4ZHA|rcsb pdb:5JQY|rcsb pdb:5JTC|rcsb pdb:5JZ8|rcsb pdb:5JZU|rcsb pdb:5K0H|rcsb pdb:5VOE|rcsb pdb:5VOF|rcsb pdb:6Q9F|rcsb pdb:6Q9I|rcsb pdb:6RK9|rcsb pdb:6YYW|rcsb pdb:6YYX|rcsb pdb:6YYY|rcsb pdb:6Z6Q|rcsb pdb:6Z6R|rcsb pdb:7BMI|rcsb pdb:7BMJ|rcsb pdb:7E6J|rcsb pdb:3TK5|reactome:R-HSA-140834|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-9672383|reactome:R-HSA-9672396|reactome:R-HSA-9673202|refseq:NP_001299603.1|refseq:NP_001299604.1|dip:DIP-29896N	go:"GO:0044403"(biological process involved in symbiotic interaction)	-	-	figure legend:Fig. 5 B and Supp. Table 1|kinetics:"Association rate constant = 8.6E6 (1/Ms), dissociation rate constant = 6.23E-4 (1/s)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/06	2014/10/16	rogid:X+5j5LFMri4Q+5Ym6ZM2gZjkZng29170	rogid:EiG38fLKwrbGJftF5k4xjLvlYhA9606	intact-crc:2D8135893005A060|rigid:K6GSzVefS3XVYes4/NqfGp9AYOg	false	sufficient binding region:8-91	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16938	uniprotkb:O88947	intact:EBI-1646299	intact:EBI-1646313|uniprotkb:O54740|uniprotkb:Q99L32|ensembl:ENSMUSP00000068389	psi-mi:q16938_ancca(display_long)	psi-mi:fa10_mouse(display_long)|uniprotkb:F10(gene name)|psi-mi:F10(display_short)|uniprotkb:Stuart factor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Waddington et al. (2008)	imex:IM-12027|pubmed:18267072|mint:MINT-6594495	taxid:29170(ancca)|taxid:29170("Ancylostoma caninum (Dog hookworm)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1646336|imex:IM-12027-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002919(Protease inhibitor I8, cysteine-rich trypsin inhibitor-like)|rcsb pdb:1COU|rcsb pdb:2H9E|interpro:IPR036084|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)	refseq:NP_031998.3|ensembl:ENSMUSG00000031444(gene)|ensembl:ENSMUST00000063820(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007596"(blood coagulation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012224(Peptidase S1A, coagulation factor VII/IX/X/C/Z)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR035972|interpro:IPR043504|reactome:R-MMU-140834|reactome:R-MMU-140837|reactome:R-MMU-140875|reactome:R-MMU-159740|reactome:R-MMU-159763|reactome:R-MMU-159782	go:"GO:0044403"(biological process involved in symbiotic interaction)	-	-	figure legend:Supp. Table 1|kinetics:"Association rate constant = 1.8E7 (1/Ms), dissociation rate constant = 3.1E-1 (1/s)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/06	2014/10/16	rogid:X+5j5LFMri4Q+5Ym6ZM2gZjkZng29170	rogid:PUJhYUafhAObcdmyHcFLnJXw2xc10090	intact-crc:732F1287AB95270D|rigid:fi7pWMjw3/7xWySQUPPlAF69nTA	false	sufficient binding region:8-91	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00742	uniprotkb:Q964Q0	intact:EBI-719750|uniprotkb:Q14340|ensembl:ENSP00000364709	intact:EBI-1646347	psi-mi:fa10_human(display_long)|uniprotkb:Stuart factor(gene name synonym)|uniprotkb:Stuart-Prower factor(gene name synonym)|uniprotkb:F10(gene name)|psi-mi:F10(display_short)	psi-mi:q964q0_ixosc(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Waddington et al. (2008)	imex:IM-12027|pubmed:18267072|mint:MINT-6594495	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6945(ixosc)|taxid:6945("Ixodes scapularis (Black-legged tick)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1646352|imex:IM-12027-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000495.1|ensembl:ENSG00000126218(gene)|ensembl:ENST00000375559(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031233"(intrinsic component of external side of plasma membrane)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012224(Peptidase S1A, coagulation factor VII/IX/X/C/Z)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR035972|interpro:IPR043504|mint:P00742|rcsb pdb:1C5M|rcsb pdb:1EZQ|rcsb pdb:1F0R|rcsb pdb:1F0S|rcsb pdb:1FAX|rcsb pdb:1FJS|rcsb pdb:1FXY|rcsb pdb:1G2L|rcsb pdb:1G2M|rcsb pdb:1HCG|rcsb pdb:1IOE|rcsb pdb:1IQE|rcsb pdb:1IQF|rcsb pdb:1IQG|rcsb pdb:1IQH|rcsb pdb:1IQI|rcsb pdb:1IQJ|rcsb pdb:1IQK|rcsb pdb:1IQL|rcsb pdb:1IQM|rcsb pdb:1IQN|rcsb pdb:1KSN|rcsb pdb:1LPG|rcsb pdb:1LPK|rcsb pdb:1LPZ|rcsb pdb:1LQD|rcsb pdb:1MQ5|rcsb pdb:1MQ6|rcsb pdb:1MSX|rcsb pdb:1NFU|rcsb pdb:1NFW|rcsb pdb:1NFX|rcsb pdb:1NFY|rcsb pdb:1NL8|rcsb pdb:1P0S|rcsb pdb:1V3X|rcsb pdb:1WU1|rcsb pdb:1XKA|rcsb pdb:1XKB|rcsb pdb:1Z6E|rcsb pdb:2BMG|rcsb pdb:2BOH|rcsb pdb:2BOK|rcsb pdb:2BQ6|rcsb pdb:2BQ7|rcsb pdb:2BQW|rcsb pdb:2CJI|rcsb pdb:2D1J|rcsb pdb:2EI6|rcsb pdb:2EI7|rcsb pdb:2EI8|rcsb pdb:2FZZ|rcsb pdb:2G00|rcsb pdb:2GD4|rcsb pdb:2H9E|rcsb pdb:2J2U|rcsb pdb:2J34|rcsb pdb:2J38|rcsb pdb:2J4I|rcsb pdb:2J94|rcsb pdb:2J95|rcsb pdb:2P16|rcsb pdb:2P3F|rcsb pdb:2P3T|rcsb pdb:2P3U|rcsb pdb:2P93|rcsb pdb:2P94|rcsb pdb:2P95|rcsb pdb:2PHB|rcsb pdb:2PR3|rcsb pdb:2Q1J|rcsb pdb:2RA0|rcsb pdb:2UWL|rcsb pdb:2UWO|rcsb pdb:2UWP|rcsb pdb:2VH0|rcsb pdb:2VH6|rcsb pdb:2VVC|rcsb pdb:2VVU|rcsb pdb:2VVV|rcsb pdb:2VWL|rcsb pdb:2VWM|rcsb pdb:2VWN|rcsb pdb:2VWO|rcsb pdb:2W26|rcsb pdb:2W3I|rcsb pdb:2W3K|rcsb pdb:2WYG|rcsb pdb:2WYJ|rcsb pdb:2XBV|rcsb pdb:2XBW|rcsb pdb:2XBX|rcsb pdb:2XBY|rcsb pdb:2XC0|rcsb pdb:2JKH|rcsb pdb:2XC4|rcsb pdb:2XC5|rcsb pdb:2Y5F|rcsb pdb:2Y5G|rcsb pdb:2Y5H|rcsb pdb:2Y7X|rcsb pdb:2Y7Z|rcsb pdb:2Y80|rcsb pdb:2Y81|rcsb pdb:2Y82|rcsb pdb:3CEN|rcsb pdb:3CS7|rcsb pdb:3ENS|rcsb pdb:3FFG|rcsb pdb:3HPT|rcsb pdb:3IIT|rcsb pdb:3K9X|rcsb pdb:3KL6|rcsb pdb:3KQB|rcsb pdb:3KQC|rcsb pdb:3KQD|rcsb pdb:3KQE|rcsb pdb:3LIW|rcsb pdb:3M36|rcsb pdb:3M37|rcsb pdb:3Q3K|rcsb pdb:3SW2|rcsb pdb:3TK6|rcsb pdb:4A7I|rcsb pdb:4BTI|rcsb pdb:4BTT|rcsb pdb:4BTU|rcsb pdb:4Y6D|rcsb pdb:4Y71|rcsb pdb:4Y76|rcsb pdb:4Y79|rcsb pdb:4Y7A|rcsb pdb:4Y7B|rcsb pdb:4ZH8|rcsb pdb:4ZHA|rcsb pdb:5JQY|rcsb pdb:5JTC|rcsb pdb:5JZ8|rcsb pdb:5JZU|rcsb pdb:5K0H|rcsb pdb:5VOE|rcsb pdb:5VOF|rcsb pdb:6Q9F|rcsb pdb:6Q9I|rcsb pdb:6RK9|rcsb pdb:6YYW|rcsb pdb:6YYX|rcsb pdb:6YYY|rcsb pdb:6Z6Q|rcsb pdb:6Z6R|rcsb pdb:7BMI|rcsb pdb:7BMJ|rcsb pdb:7E6J|rcsb pdb:3TK5|reactome:R-HSA-140834|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-9672383|reactome:R-HSA-9672396|reactome:R-HSA-9673202|refseq:NP_001299603.1|refseq:NP_001299604.1|dip:DIP-29896N	interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR036880|rcsb pdb:6NAN|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)	go:"GO:0044403"(biological process involved in symbiotic interaction)	-	-	figure legend:Fig. 5B and Supp. Table 1|kinetics:"Association rate constant = 1.35E5 (1/Ms), dissociation rate constant = 1.75E-4 (1/s)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/06	2014/10/16	rogid:EiG38fLKwrbGJftF5k4xjLvlYhA9606	rogid:kSFViJM45+u8qCNh5QhdRHOFx7M6945	intact-crc:88D439F983087C4C|rigid:0cymGlb5C2yAYZ+KpV5uIZ3JYb8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O88947	uniprotkb:Q964Q0	intact:EBI-1646313|uniprotkb:O54740|uniprotkb:Q99L32|ensembl:ENSMUSP00000068389	intact:EBI-1646347	psi-mi:fa10_mouse(display_long)|uniprotkb:F10(gene name)|psi-mi:F10(display_short)|uniprotkb:Stuart factor(gene name synonym)	psi-mi:q964q0_ixosc(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Waddington et al. (2008)	imex:IM-12027|pubmed:18267072|mint:MINT-6594495	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:6945(ixosc)|taxid:6945("Ixodes scapularis (Black-legged tick)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1646370|imex:IM-12027-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031998.3|ensembl:ENSMUSG00000031444(gene)|ensembl:ENSMUST00000063820(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007596"(blood coagulation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012224(Peptidase S1A, coagulation factor VII/IX/X/C/Z)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR035972|interpro:IPR043504|reactome:R-MMU-140834|reactome:R-MMU-140837|reactome:R-MMU-140875|reactome:R-MMU-159740|reactome:R-MMU-159763|reactome:R-MMU-159782	interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR036880|rcsb pdb:6NAN|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)	go:"GO:0044403"(biological process involved in symbiotic interaction)	-	-	figure legend:Supp. Table 1|kinetics:"Association rate constant = 1.57E6 (1/Ms), dissociation rate constant = 8.1E-7 (1/s)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/06	2014/10/16	rogid:PUJhYUafhAObcdmyHcFLnJXw2xc10090	rogid:kSFViJM45+u8qCNh5QhdRHOFx7M6945	intact-crc:A24048962E98F84E|rigid:v2u1y0bkf6cOf6dxxCh9sC3WssU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)