#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P31785	uniprotkb:P05112	intact:EBI-80475|ensembl:ENSP00000363318|uniprotkb:Q5FC12	intact:EBI-367025|uniprotkb:Q14630|uniprotkb:Q6NZ77|ensembl:ENSP00000231449	psi-mi:il2rg_human(display_long)|uniprotkb:IL2RG(gene name)|psi-mi:IL2RG(display_short)|uniprotkb:p64(gene name synonym)|uniprotkb:gammaC(gene name synonym)|uniprotkb:Interleukin-2 receptor subunit gamma(gene name synonym)	psi-mi:il4_human(display_long)|uniprotkb:IL4(gene name)|psi-mi:IL4(display_short)|uniprotkb:B-cell stimulatory factor 1(gene name synonym)|uniprotkb:Lymphocyte stimulatory factor 1(gene name synonym)|uniprotkb:Binetrakin(gene name synonym)|uniprotkb:Pitrakinra(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	LaPorte et al. (2008)	imex:IM-12023|pubmed:18243101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1644864|wwpdb:3bpl|imex:IM-12023-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147168(gene)|ensembl:ENST00000374202(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0019976"(interleukin-2 binding)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0038111"(interleukin-7-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|rcsb pdb:1ILL|rcsb pdb:1ILM|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:1ILN|rcsb pdb:1ITE|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3BPL|rcsb pdb:3QAZ|rcsb pdb:3QB7|rcsb pdb:4GS7|rcsb pdb:5M5E|rcsb pdb:6OEL|reactome:R-HSA-1266695|reactome:R-HSA-5673001|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|reactome:R-HSA-6785807|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-912526|refseq:NP_000197.1|dip:DIP-173N	refseq:NP_000580.1|refseq:NP_758858.1|ensembl:ENSG00000113520(gene)|ensembl:ENST00000231449(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005136"(interleukin-4 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031296"(B cell costimulation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042116"(macrophage activation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000424"(positive regulation of eosinophil chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR002354(Interleukin 4)|interpro:IPR009079(Four-helical cytokine-like, core)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|rcsb pdb:1BBN|rcsb pdb:1BCN|rcsb pdb:1CYL|rcsb pdb:1HIJ|rcsb pdb:1HIK|rcsb pdb:1HZI|rcsb pdb:1IAR|rcsb pdb:1ILL|rcsb pdb:1ITE|rcsb pdb:1ITI|rcsb pdb:1ITL|rcsb pdb:1ITM|rcsb pdb:1RCB|rcsb pdb:2B8U|rcsb pdb:2B8X|rcsb pdb:2B8Y|rcsb pdb:2B8Z|rcsb pdb:2B90|rcsb pdb:2B91|rcsb pdb:2CYK|rcsb pdb:2D48|rcsb pdb:2INT|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3QB7|rcsb pdb:4YDY|rcsb pdb:5FHX|rcsb pdb:6OEL|reactome:R-HSA-6785807|reactome:R-HSA-9012546|interpro:IPR018096|dip:DIP-3222N	-	-	-	figure legend:S1 and S2, Table S1|3d-resolution:2.95 A|3d-r-factors:R free = 29.7; R cryst = 22.6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/04	2014/10/16	rogid:Fz1gJI4Qk1jAguOQqWXbAWUb/8o9606	rogid:Jmojsmx7uQfFInaExASOKFttPFk9606	intact-crc:4890D0F9A41BC0CF|rigid:jx7tRKUYuJbYdV5XdDTG26TiTlc	false	sufficient binding region:56-254	sufficient binding region:25-153	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31785	uniprotkb:P24394	intact:EBI-80475|ensembl:ENSP00000363318|uniprotkb:Q5FC12	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	psi-mi:il2rg_human(display_long)|uniprotkb:IL2RG(gene name)|psi-mi:IL2RG(display_short)|uniprotkb:p64(gene name synonym)|uniprotkb:gammaC(gene name synonym)|uniprotkb:Interleukin-2 receptor subunit gamma(gene name synonym)	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	LaPorte et al. (2008)	imex:IM-12023|pubmed:18243101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1644864|wwpdb:3bpl|imex:IM-12023-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147168(gene)|ensembl:ENST00000374202(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0019976"(interleukin-2 binding)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0038111"(interleukin-7-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|rcsb pdb:1ILL|rcsb pdb:1ILM|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:1ILN|rcsb pdb:1ITE|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3BPL|rcsb pdb:3QAZ|rcsb pdb:3QB7|rcsb pdb:4GS7|rcsb pdb:5M5E|rcsb pdb:6OEL|reactome:R-HSA-1266695|reactome:R-HSA-5673001|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|reactome:R-HSA-6785807|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-912526|refseq:NP_000197.1|dip:DIP-173N	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	-	-	-	figure legend:S1 and S2, Table S1|3d-resolution:2.95 A|3d-r-factors:R free = 29.7; R cryst = 22.6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/04	2014/10/16	rogid:Fz1gJI4Qk1jAguOQqWXbAWUb/8o9606	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	intact-crc:4890D0F9A41BC0CF|rigid:jx7tRKUYuJbYdV5XdDTG26TiTlc	false	sufficient binding region:56-254	sufficient binding region:27-227	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78552	uniprotkb:P05112	intact:EBI-1391535|uniprotkb:O95646|uniprotkb:Q99656|intact:EBI-3918927|uniprotkb:Q5JSL4|uniprotkb:Q9UDY5|ensembl:ENSP00000360730	intact:EBI-367025|uniprotkb:Q14630|uniprotkb:Q6NZ77|ensembl:ENSP00000231449	psi-mi:i13r1_human(display_long)|uniprotkb:Cancer/testis antigen 19(gene name synonym)|uniprotkb:IL13RA1(gene name)|psi-mi:IL13RA1(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:IL13RA(gene name synonym)	psi-mi:il4_human(display_long)|uniprotkb:IL4(gene name)|psi-mi:IL4(display_short)|uniprotkb:B-cell stimulatory factor 1(gene name synonym)|uniprotkb:Lymphocyte stimulatory factor 1(gene name synonym)|uniprotkb:Binetrakin(gene name synonym)|uniprotkb:Pitrakinra(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	LaPorte et al. (2008)	imex:IM-12023|pubmed:18243101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1644999|wwpdb:3bpn|imex:IM-12023-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001551.1|dip:DIP-3225N|ensembl:ENSG00000131724(gene)|interpro:IPR036116|interpro:IPR040566|rcsb pdb:3BPN|ensembl:ENST00000371666(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005898"(interleukin-13 receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|rcsb pdb:3BPO|rcsb pdb:4HWB|rcsb pdb:5E4E|reactome:R-HSA-6785807	refseq:NP_000580.1|refseq:NP_758858.1|ensembl:ENSG00000113520(gene)|ensembl:ENST00000231449(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005136"(interleukin-4 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031296"(B cell costimulation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042116"(macrophage activation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000424"(positive regulation of eosinophil chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR002354(Interleukin 4)|interpro:IPR009079(Four-helical cytokine-like, core)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|rcsb pdb:1BBN|rcsb pdb:1BCN|rcsb pdb:1CYL|rcsb pdb:1HIJ|rcsb pdb:1HIK|rcsb pdb:1HZI|rcsb pdb:1IAR|rcsb pdb:1ILL|rcsb pdb:1ITE|rcsb pdb:1ITI|rcsb pdb:1ITL|rcsb pdb:1ITM|rcsb pdb:1RCB|rcsb pdb:2B8U|rcsb pdb:2B8X|rcsb pdb:2B8Y|rcsb pdb:2B8Z|rcsb pdb:2B90|rcsb pdb:2B91|rcsb pdb:2CYK|rcsb pdb:2D48|rcsb pdb:2INT|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3QB7|rcsb pdb:4YDY|rcsb pdb:5FHX|rcsb pdb:6OEL|reactome:R-HSA-6785807|reactome:R-HSA-9012546|interpro:IPR018096|dip:DIP-3222N	-	-	-	figure legend:S1, S2, Table S1|3d-resolution:3.0 A|3d-r-factors:R free = 30.4; R cryst = 23.8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/04	2014/10/16	rogid:EufIBLLPq2hkBrfc1evg9tTfp1o9606	rogid:Jmojsmx7uQfFInaExASOKFttPFk9606	intact-crc:C2D5418EDB4290D4|rigid:RrLgpQAntKF4zEa6O0usYp1UgNQ	false	sufficient binding region:29-342	sufficient binding region:25-153	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78552	uniprotkb:P24394	intact:EBI-1391535|uniprotkb:O95646|uniprotkb:Q99656|intact:EBI-3918927|uniprotkb:Q5JSL4|uniprotkb:Q9UDY5|ensembl:ENSP00000360730	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	psi-mi:i13r1_human(display_long)|uniprotkb:Cancer/testis antigen 19(gene name synonym)|uniprotkb:IL13RA1(gene name)|psi-mi:IL13RA1(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:IL13RA(gene name synonym)	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	LaPorte et al. (2008)	imex:IM-12023|pubmed:18243101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1644999|wwpdb:3bpn|imex:IM-12023-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001551.1|dip:DIP-3225N|ensembl:ENSG00000131724(gene)|interpro:IPR036116|interpro:IPR040566|rcsb pdb:3BPN|ensembl:ENST00000371666(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005898"(interleukin-13 receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|rcsb pdb:3BPO|rcsb pdb:4HWB|rcsb pdb:5E4E|reactome:R-HSA-6785807	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	-	-	-	figure legend:S1, S2, Table S1|3d-resolution:3.0 A|3d-r-factors:R free = 30.4; R cryst = 23.8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/04	2014/10/16	rogid:EufIBLLPq2hkBrfc1evg9tTfp1o9606	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	intact-crc:C2D5418EDB4290D4|rigid:RrLgpQAntKF4zEa6O0usYp1UgNQ	false	sufficient binding region:29-342	sufficient binding region:27-227	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78552	uniprotkb:P35225	intact:EBI-1391535|uniprotkb:O95646|uniprotkb:Q99656|intact:EBI-3918927|uniprotkb:Q5JSL4|uniprotkb:Q9UDY5|ensembl:ENSP00000360730	intact:EBI-1647828|uniprotkb:O43644|uniprotkb:Q4VB52|uniprotkb:Q9UDC7|ensembl:ENSP00000304915	psi-mi:i13r1_human(display_long)|uniprotkb:Cancer/testis antigen 19(gene name synonym)|uniprotkb:IL13RA1(gene name)|psi-mi:IL13RA1(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:IL13RA(gene name synonym)	psi-mi:il13_human(display_long)|uniprotkb:IL13(gene name)|psi-mi:IL13(display_short)|uniprotkb:NC30(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	LaPorte et al. (2008)	imex:IM-12023|pubmed:18243101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1645027|wwpdb:3bpo|imex:IM-12023-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001551.1|dip:DIP-3225N|ensembl:ENSG00000131724(gene)|interpro:IPR036116|interpro:IPR040566|rcsb pdb:3BPN|ensembl:ENST00000371666(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005898"(interleukin-13 receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|rcsb pdb:3BPO|rcsb pdb:4HWB|rcsb pdb:5E4E|reactome:R-HSA-6785807	refseq:NP_002179.2|dip:DIP-3224N|ensembl:ENSG00000169194(gene)|ensembl:ENST00000304506(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045471"(response to ethanol)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901247"(negative regulation of lung ciliated cell differentiation)|go:"GO:1901251"(positive regulation of lung goblet cell differentiation)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470|rcsb pdb:1GA3|rcsb pdb:1IJZ|rcsb pdb:1IK0|rcsb pdb:1J9U|rcsb pdb:3BPO|rcsb pdb:3G6D|rcsb pdb:3ITR|rcsb pdb:3ITS|rcsb pdb:3L5W|rcsb pdb:3L5X|rcsb pdb:3LB6|rcsb pdb:4I77|rcsb pdb:4PS4|rcsb pdb:5E4E|rcsb pdb:5L6Y|reactome:R-HSA-6785807|reactome:R-HSA-9012546	-	-	-	figure legend:S1, S2, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/04	2014/10/16	rogid:EufIBLLPq2hkBrfc1evg9tTfp1o9606	rogid:NORPxfYHTfYxQaFWP3FFlC76bWE9606	intact-crc:847DA53F875B1E83|rigid:ZwT0wsfm84u3Cf2tZSb9phtt150	false	sufficient binding region:29-342	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78552	uniprotkb:P24394	intact:EBI-1391535|uniprotkb:O95646|uniprotkb:Q99656|intact:EBI-3918927|uniprotkb:Q5JSL4|uniprotkb:Q9UDY5|ensembl:ENSP00000360730	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	psi-mi:i13r1_human(display_long)|uniprotkb:Cancer/testis antigen 19(gene name synonym)|uniprotkb:IL13RA1(gene name)|psi-mi:IL13RA1(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:IL13RA(gene name synonym)	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	LaPorte et al. (2008)	imex:IM-12023|pubmed:18243101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1645027|wwpdb:3bpo|imex:IM-12023-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001551.1|dip:DIP-3225N|ensembl:ENSG00000131724(gene)|interpro:IPR036116|interpro:IPR040566|rcsb pdb:3BPN|ensembl:ENST00000371666(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005898"(interleukin-13 receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|rcsb pdb:3BPO|rcsb pdb:4HWB|rcsb pdb:5E4E|reactome:R-HSA-6785807	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	-	-	-	figure legend:S1, S2, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/04	2014/10/16	rogid:EufIBLLPq2hkBrfc1evg9tTfp1o9606	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	intact-crc:847DA53F875B1E83|rigid:ZwT0wsfm84u3Cf2tZSb9phtt150	false	sufficient binding region:29-342	sufficient binding region:27-227	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78552	uniprotkb:P35225	intact:EBI-1391535|uniprotkb:O95646|uniprotkb:Q99656|intact:EBI-3918927|uniprotkb:Q5JSL4|uniprotkb:Q9UDY5|ensembl:ENSP00000360730	intact:EBI-1647828|uniprotkb:O43644|uniprotkb:Q4VB52|uniprotkb:Q9UDC7|ensembl:ENSP00000304915	psi-mi:i13r1_human(display_long)|uniprotkb:Cancer/testis antigen 19(gene name synonym)|uniprotkb:IL13RA1(gene name)|psi-mi:IL13RA1(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:IL13RA(gene name synonym)	psi-mi:il13_human(display_long)|uniprotkb:IL13(gene name)|psi-mi:IL13(display_short)|uniprotkb:NC30(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	LaPorte et al. (2008)	imex:IM-12023|pubmed:18243101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1645048|imex:IM-12023-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001551.1|dip:DIP-3225N|ensembl:ENSG00000131724(gene)|interpro:IPR036116|interpro:IPR040566|rcsb pdb:3BPN|ensembl:ENST00000371666(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005898"(interleukin-13 receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|rcsb pdb:3BPO|rcsb pdb:4HWB|rcsb pdb:5E4E|reactome:R-HSA-6785807	refseq:NP_002179.2|dip:DIP-3224N|ensembl:ENSG00000169194(gene)|ensembl:ENST00000304506(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045471"(response to ethanol)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901247"(negative regulation of lung ciliated cell differentiation)|go:"GO:1901251"(positive regulation of lung goblet cell differentiation)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470|rcsb pdb:1GA3|rcsb pdb:1IJZ|rcsb pdb:1IK0|rcsb pdb:1J9U|rcsb pdb:3BPO|rcsb pdb:3G6D|rcsb pdb:3ITR|rcsb pdb:3ITS|rcsb pdb:3L5W|rcsb pdb:3L5X|rcsb pdb:3LB6|rcsb pdb:4I77|rcsb pdb:4PS4|rcsb pdb:5E4E|rcsb pdb:5L6Y|reactome:R-HSA-6785807|reactome:R-HSA-9012546	psi-mi:"MI:0469"(intact)	-	-	figure legend:S5 A, B|comment:The IL-13Ralpha1 D1 domain is required for IL-13 binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2008/03/04	2014/10/16	rogid:EufIBLLPq2hkBrfc1evg9tTfp1o9606	rogid:NORPxfYHTfYxQaFWP3FFlC76bWE9606	intact-crc:DAA65A6BFD32139C|rigid:Z1zIbPxztQp3LG7UOVwxlKhUFMk	false	necessary binding region:32-119	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78552	uniprotkb:P05112	intact:EBI-1391535|uniprotkb:O95646|uniprotkb:Q99656|intact:EBI-3918927|uniprotkb:Q5JSL4|uniprotkb:Q9UDY5|ensembl:ENSP00000360730	intact:EBI-367025|uniprotkb:Q14630|uniprotkb:Q6NZ77|ensembl:ENSP00000231449	psi-mi:i13r1_human(display_long)|uniprotkb:Cancer/testis antigen 19(gene name synonym)|uniprotkb:IL13RA1(gene name)|psi-mi:IL13RA1(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:IL13RA(gene name synonym)	psi-mi:il4_human(display_long)|uniprotkb:IL4(gene name)|psi-mi:IL4(display_short)|uniprotkb:B-cell stimulatory factor 1(gene name synonym)|uniprotkb:Lymphocyte stimulatory factor 1(gene name synonym)|uniprotkb:Binetrakin(gene name synonym)|uniprotkb:Pitrakinra(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	LaPorte et al. (2008)	imex:IM-12023|pubmed:18243101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1645059|imex:IM-12023-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001551.1|dip:DIP-3225N|ensembl:ENSG00000131724(gene)|interpro:IPR036116|interpro:IPR040566|rcsb pdb:3BPN|ensembl:ENST00000371666(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005898"(interleukin-13 receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|rcsb pdb:3BPO|rcsb pdb:4HWB|rcsb pdb:5E4E|reactome:R-HSA-6785807	refseq:NP_000580.1|refseq:NP_758858.1|ensembl:ENSG00000113520(gene)|ensembl:ENST00000231449(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005136"(interleukin-4 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031296"(B cell costimulation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042116"(macrophage activation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000424"(positive regulation of eosinophil chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR002354(Interleukin 4)|interpro:IPR009079(Four-helical cytokine-like, core)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|rcsb pdb:1BBN|rcsb pdb:1BCN|rcsb pdb:1CYL|rcsb pdb:1HIJ|rcsb pdb:1HIK|rcsb pdb:1HZI|rcsb pdb:1IAR|rcsb pdb:1ILL|rcsb pdb:1ITE|rcsb pdb:1ITI|rcsb pdb:1ITL|rcsb pdb:1ITM|rcsb pdb:1RCB|rcsb pdb:2B8U|rcsb pdb:2B8X|rcsb pdb:2B8Y|rcsb pdb:2B8Z|rcsb pdb:2B90|rcsb pdb:2B91|rcsb pdb:2CYK|rcsb pdb:2D48|rcsb pdb:2INT|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3QB7|rcsb pdb:4YDY|rcsb pdb:5FHX|rcsb pdb:6OEL|reactome:R-HSA-6785807|reactome:R-HSA-9012546|interpro:IPR018096|dip:DIP-3222N	psi-mi:"MI:0469"(intact)	-	-	figure legend:S5 C|comment:The IL-13Ralpha1 D1 domain is required for IL-13 binding but not IL-4 binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2008/03/04	2014/10/16	rogid:EufIBLLPq2hkBrfc1evg9tTfp1o9606	rogid:Jmojsmx7uQfFInaExASOKFttPFk9606	intact-crc:4B2D42A789F3AD03|rigid:nBNk98mJZE816MuDT36dLOc6/UU	false	necessary binding region:129-342	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31785	uniprotkb:P05112	intact:EBI-80475|ensembl:ENSP00000363318|uniprotkb:Q5FC12	intact:EBI-367025|uniprotkb:Q14630|uniprotkb:Q6NZ77|ensembl:ENSP00000231449	psi-mi:il2rg_human(display_long)|uniprotkb:IL2RG(gene name)|psi-mi:IL2RG(display_short)|uniprotkb:p64(gene name synonym)|uniprotkb:gammaC(gene name synonym)|uniprotkb:Interleukin-2 receptor subunit gamma(gene name synonym)	psi-mi:il4_human(display_long)|uniprotkb:IL4(gene name)|psi-mi:IL4(display_short)|uniprotkb:B-cell stimulatory factor 1(gene name synonym)|uniprotkb:Lymphocyte stimulatory factor 1(gene name synonym)|uniprotkb:Binetrakin(gene name synonym)|uniprotkb:Pitrakinra(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	LaPorte et al. (2008)	imex:IM-12023|pubmed:18243101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1645074|imex:IM-12023-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147168(gene)|ensembl:ENST00000374202(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0019976"(interleukin-2 binding)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0038111"(interleukin-7-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|rcsb pdb:1ILL|rcsb pdb:1ILM|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:1ILN|rcsb pdb:1ITE|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3BPL|rcsb pdb:3QAZ|rcsb pdb:3QB7|rcsb pdb:4GS7|rcsb pdb:5M5E|rcsb pdb:6OEL|reactome:R-HSA-1266695|reactome:R-HSA-5673001|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|reactome:R-HSA-6785807|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-912526|refseq:NP_000197.1|dip:DIP-173N	refseq:NP_000580.1|refseq:NP_758858.1|ensembl:ENSG00000113520(gene)|ensembl:ENST00000231449(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005136"(interleukin-4 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031296"(B cell costimulation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042116"(macrophage activation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000424"(positive regulation of eosinophil chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR002354(Interleukin 4)|interpro:IPR009079(Four-helical cytokine-like, core)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|rcsb pdb:1BBN|rcsb pdb:1BCN|rcsb pdb:1CYL|rcsb pdb:1HIJ|rcsb pdb:1HIK|rcsb pdb:1HZI|rcsb pdb:1IAR|rcsb pdb:1ILL|rcsb pdb:1ITE|rcsb pdb:1ITI|rcsb pdb:1ITL|rcsb pdb:1ITM|rcsb pdb:1RCB|rcsb pdb:2B8U|rcsb pdb:2B8X|rcsb pdb:2B8Y|rcsb pdb:2B8Z|rcsb pdb:2B90|rcsb pdb:2B91|rcsb pdb:2CYK|rcsb pdb:2D48|rcsb pdb:2INT|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3QB7|rcsb pdb:4YDY|rcsb pdb:5FHX|rcsb pdb:6OEL|reactome:R-HSA-6785807|reactome:R-HSA-9012546|interpro:IPR018096|dip:DIP-3222N	psi-mi:"MI:0469"(intact)	-	-	figure legend:3 A, Table S3|comment:IL-4 first binds to IL-4Ra, followed by recruitment of gammac to form a ternary complex.|kinetics:The Kd of IL-4 binding to IL-4Ralpha = 1.0 E-9 M; the Kd of gammac binding to IL-4/IL-4Ralpha = 5.59 E-7 M.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/04	2014/10/16	rogid:Fz1gJI4Qk1jAguOQqWXbAWUb/8o9606	rogid:Jmojsmx7uQfFInaExASOKFttPFk9606	intact-crc:77A7C8CBBFE69A11|rigid:jx7tRKUYuJbYdV5XdDTG26TiTlc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31785	uniprotkb:P24394	intact:EBI-80475|ensembl:ENSP00000363318|uniprotkb:Q5FC12	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	psi-mi:il2rg_human(display_long)|uniprotkb:IL2RG(gene name)|psi-mi:IL2RG(display_short)|uniprotkb:p64(gene name synonym)|uniprotkb:gammaC(gene name synonym)|uniprotkb:Interleukin-2 receptor subunit gamma(gene name synonym)	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	LaPorte et al. (2008)	imex:IM-12023|pubmed:18243101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1645074|imex:IM-12023-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147168(gene)|ensembl:ENST00000374202(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0019976"(interleukin-2 binding)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0038111"(interleukin-7-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|rcsb pdb:1ILL|rcsb pdb:1ILM|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:1ILN|rcsb pdb:1ITE|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3BPL|rcsb pdb:3QAZ|rcsb pdb:3QB7|rcsb pdb:4GS7|rcsb pdb:5M5E|rcsb pdb:6OEL|reactome:R-HSA-1266695|reactome:R-HSA-5673001|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|reactome:R-HSA-6785807|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-912526|refseq:NP_000197.1|dip:DIP-173N	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	psi-mi:"MI:0469"(intact)	-	-	figure legend:3 A, Table S3|comment:IL-4 first binds to IL-4Ra, followed by recruitment of gammac to form a ternary complex.|kinetics:The Kd of IL-4 binding to IL-4Ralpha = 1.0 E-9 M; the Kd of gammac binding to IL-4/IL-4Ralpha = 5.59 E-7 M.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/04	2014/10/16	rogid:Fz1gJI4Qk1jAguOQqWXbAWUb/8o9606	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	intact-crc:77A7C8CBBFE69A11|rigid:jx7tRKUYuJbYdV5XdDTG26TiTlc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78552	uniprotkb:P05112	intact:EBI-1391535|uniprotkb:O95646|uniprotkb:Q99656|intact:EBI-3918927|uniprotkb:Q5JSL4|uniprotkb:Q9UDY5|ensembl:ENSP00000360730	intact:EBI-367025|uniprotkb:Q14630|uniprotkb:Q6NZ77|ensembl:ENSP00000231449	psi-mi:i13r1_human(display_long)|uniprotkb:Cancer/testis antigen 19(gene name synonym)|uniprotkb:IL13RA1(gene name)|psi-mi:IL13RA1(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:IL13RA(gene name synonym)	psi-mi:il4_human(display_long)|uniprotkb:IL4(gene name)|psi-mi:IL4(display_short)|uniprotkb:B-cell stimulatory factor 1(gene name synonym)|uniprotkb:Lymphocyte stimulatory factor 1(gene name synonym)|uniprotkb:Binetrakin(gene name synonym)|uniprotkb:Pitrakinra(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	LaPorte et al. (2008)	imex:IM-12023|pubmed:18243101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1645083|imex:IM-12023-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001551.1|dip:DIP-3225N|ensembl:ENSG00000131724(gene)|interpro:IPR036116|interpro:IPR040566|rcsb pdb:3BPN|ensembl:ENST00000371666(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005898"(interleukin-13 receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|rcsb pdb:3BPO|rcsb pdb:4HWB|rcsb pdb:5E4E|reactome:R-HSA-6785807	refseq:NP_000580.1|refseq:NP_758858.1|ensembl:ENSG00000113520(gene)|ensembl:ENST00000231449(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005136"(interleukin-4 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031296"(B cell costimulation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042116"(macrophage activation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000424"(positive regulation of eosinophil chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR002354(Interleukin 4)|interpro:IPR009079(Four-helical cytokine-like, core)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|rcsb pdb:1BBN|rcsb pdb:1BCN|rcsb pdb:1CYL|rcsb pdb:1HIJ|rcsb pdb:1HIK|rcsb pdb:1HZI|rcsb pdb:1IAR|rcsb pdb:1ILL|rcsb pdb:1ITE|rcsb pdb:1ITI|rcsb pdb:1ITL|rcsb pdb:1ITM|rcsb pdb:1RCB|rcsb pdb:2B8U|rcsb pdb:2B8X|rcsb pdb:2B8Y|rcsb pdb:2B8Z|rcsb pdb:2B90|rcsb pdb:2B91|rcsb pdb:2CYK|rcsb pdb:2D48|rcsb pdb:2INT|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3QB7|rcsb pdb:4YDY|rcsb pdb:5FHX|rcsb pdb:6OEL|reactome:R-HSA-6785807|reactome:R-HSA-9012546|interpro:IPR018096|dip:DIP-3222N	psi-mi:"MI:0469"(intact)	-	-	figure legend:3 B, Table S3|comment:For the type II IL-4 complex, IL-4 first binds to IL-4Ra followed by recruitment of IL-13Ralpha1.|kinetics:Kd for binding of IL-4 to IL-4Ralpha = 1.0 E-9 M; Kd of binding of IL-13Ralpha1 to IL-4/IL-4Ralpha = 4.87 E-7 M|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/04	2014/10/16	rogid:EufIBLLPq2hkBrfc1evg9tTfp1o9606	rogid:Jmojsmx7uQfFInaExASOKFttPFk9606	intact-crc:A21200C6E0B4D10C|rigid:RrLgpQAntKF4zEa6O0usYp1UgNQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78552	uniprotkb:P24394	intact:EBI-1391535|uniprotkb:O95646|uniprotkb:Q99656|intact:EBI-3918927|uniprotkb:Q5JSL4|uniprotkb:Q9UDY5|ensembl:ENSP00000360730	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	psi-mi:i13r1_human(display_long)|uniprotkb:Cancer/testis antigen 19(gene name synonym)|uniprotkb:IL13RA1(gene name)|psi-mi:IL13RA1(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:IL13RA(gene name synonym)	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	LaPorte et al. (2008)	imex:IM-12023|pubmed:18243101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1645083|imex:IM-12023-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001551.1|dip:DIP-3225N|ensembl:ENSG00000131724(gene)|interpro:IPR036116|interpro:IPR040566|rcsb pdb:3BPN|ensembl:ENST00000371666(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005898"(interleukin-13 receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|rcsb pdb:3BPO|rcsb pdb:4HWB|rcsb pdb:5E4E|reactome:R-HSA-6785807	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	psi-mi:"MI:0469"(intact)	-	-	figure legend:3 B, Table S3|comment:For the type II IL-4 complex, IL-4 first binds to IL-4Ra followed by recruitment of IL-13Ralpha1.|kinetics:Kd for binding of IL-4 to IL-4Ralpha = 1.0 E-9 M; Kd of binding of IL-13Ralpha1 to IL-4/IL-4Ralpha = 4.87 E-7 M|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/04	2014/10/16	rogid:EufIBLLPq2hkBrfc1evg9tTfp1o9606	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	intact-crc:A21200C6E0B4D10C|rigid:RrLgpQAntKF4zEa6O0usYp1UgNQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78552	uniprotkb:P35225	intact:EBI-1391535|uniprotkb:O95646|uniprotkb:Q99656|intact:EBI-3918927|uniprotkb:Q5JSL4|uniprotkb:Q9UDY5|ensembl:ENSP00000360730	intact:EBI-1647828|uniprotkb:O43644|uniprotkb:Q4VB52|uniprotkb:Q9UDC7|ensembl:ENSP00000304915	psi-mi:i13r1_human(display_long)|uniprotkb:Cancer/testis antigen 19(gene name synonym)|uniprotkb:IL13RA1(gene name)|psi-mi:IL13RA1(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:IL13RA(gene name synonym)	psi-mi:il13_human(display_long)|uniprotkb:IL13(gene name)|psi-mi:IL13(display_short)|uniprotkb:NC30(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	LaPorte et al. (2008)	imex:IM-12023|pubmed:18243101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1645096|imex:IM-12023-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001551.1|dip:DIP-3225N|ensembl:ENSG00000131724(gene)|interpro:IPR036116|interpro:IPR040566|rcsb pdb:3BPN|ensembl:ENST00000371666(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005898"(interleukin-13 receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|rcsb pdb:3BPO|rcsb pdb:4HWB|rcsb pdb:5E4E|reactome:R-HSA-6785807	refseq:NP_002179.2|dip:DIP-3224N|ensembl:ENSG00000169194(gene)|ensembl:ENST00000304506(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045471"(response to ethanol)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901247"(negative regulation of lung ciliated cell differentiation)|go:"GO:1901251"(positive regulation of lung goblet cell differentiation)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470|rcsb pdb:1GA3|rcsb pdb:1IJZ|rcsb pdb:1IK0|rcsb pdb:1J9U|rcsb pdb:3BPO|rcsb pdb:3G6D|rcsb pdb:3ITR|rcsb pdb:3ITS|rcsb pdb:3L5W|rcsb pdb:3L5X|rcsb pdb:3LB6|rcsb pdb:4I77|rcsb pdb:4PS4|rcsb pdb:5E4E|rcsb pdb:5L6Y|reactome:R-HSA-6785807|reactome:R-HSA-9012546	psi-mi:"MI:0469"(intact)	-	-	figure legend:3 C, Table S3|comment:For the IL-13 complex, IL-13 first binds IL-13Ralpha1 and this binary complex then recruits IL-4Ralpha.|kinetics:Kd for IL-13 binding to IL-13Ralpha1 = 3.0 E-8 M; Kd for binding of IL-4Ralpha to IL-13/IL-13Ralpha1 = 2.0 E-8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/04	2014/10/16	rogid:EufIBLLPq2hkBrfc1evg9tTfp1o9606	rogid:NORPxfYHTfYxQaFWP3FFlC76bWE9606	intact-crc:76A507786E9A9CA8|rigid:ZwT0wsfm84u3Cf2tZSb9phtt150	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78552	uniprotkb:P24394	intact:EBI-1391535|uniprotkb:O95646|uniprotkb:Q99656|intact:EBI-3918927|uniprotkb:Q5JSL4|uniprotkb:Q9UDY5|ensembl:ENSP00000360730	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	psi-mi:i13r1_human(display_long)|uniprotkb:Cancer/testis antigen 19(gene name synonym)|uniprotkb:IL13RA1(gene name)|psi-mi:IL13RA1(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:IL13RA(gene name synonym)	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	LaPorte et al. (2008)	imex:IM-12023|pubmed:18243101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1645096|imex:IM-12023-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001551.1|dip:DIP-3225N|ensembl:ENSG00000131724(gene)|interpro:IPR036116|interpro:IPR040566|rcsb pdb:3BPN|ensembl:ENST00000371666(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005898"(interleukin-13 receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|rcsb pdb:3BPO|rcsb pdb:4HWB|rcsb pdb:5E4E|reactome:R-HSA-6785807	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	psi-mi:"MI:0469"(intact)	-	-	figure legend:3 C, Table S3|comment:For the IL-13 complex, IL-13 first binds IL-13Ralpha1 and this binary complex then recruits IL-4Ralpha.|kinetics:Kd for IL-13 binding to IL-13Ralpha1 = 3.0 E-8 M; Kd for binding of IL-4Ralpha to IL-13/IL-13Ralpha1 = 2.0 E-8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/04	2014/10/16	rogid:EufIBLLPq2hkBrfc1evg9tTfp1o9606	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	intact-crc:76A507786E9A9CA8|rigid:ZwT0wsfm84u3Cf2tZSb9phtt150	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24394	uniprotkb:P05112	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	intact:EBI-367025|uniprotkb:Q14630|uniprotkb:Q6NZ77|ensembl:ENSP00000231449	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:il4_human(display_long)|uniprotkb:IL4(gene name)|psi-mi:IL4(display_short)|uniprotkb:B-cell stimulatory factor 1(gene name synonym)|uniprotkb:Lymphocyte stimulatory factor 1(gene name synonym)|uniprotkb:Binetrakin(gene name synonym)|uniprotkb:Pitrakinra(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	LaPorte et al. (2008)	imex:IM-12023|pubmed:18243101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1647865|imex:IM-12023-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	refseq:NP_000580.1|refseq:NP_758858.1|ensembl:ENSG00000113520(gene)|ensembl:ENST00000231449(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005136"(interleukin-4 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031296"(B cell costimulation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042116"(macrophage activation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000424"(positive regulation of eosinophil chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR002354(Interleukin 4)|interpro:IPR009079(Four-helical cytokine-like, core)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|rcsb pdb:1BBN|rcsb pdb:1BCN|rcsb pdb:1CYL|rcsb pdb:1HIJ|rcsb pdb:1HIK|rcsb pdb:1HZI|rcsb pdb:1IAR|rcsb pdb:1ILL|rcsb pdb:1ITE|rcsb pdb:1ITI|rcsb pdb:1ITL|rcsb pdb:1ITM|rcsb pdb:1RCB|rcsb pdb:2B8U|rcsb pdb:2B8X|rcsb pdb:2B8Y|rcsb pdb:2B8Z|rcsb pdb:2B90|rcsb pdb:2B91|rcsb pdb:2CYK|rcsb pdb:2D48|rcsb pdb:2INT|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3QB7|rcsb pdb:4YDY|rcsb pdb:5FHX|rcsb pdb:6OEL|reactome:R-HSA-6785807|reactome:R-HSA-9012546|interpro:IPR018096|dip:DIP-3222N	psi-mi:"MI:0469"(intact)	-	-	figure legend:3 A, B, Table S3|kinetics:Kd for binding of IL-4 to IL-4Ralpha = 1.0 E-9 M|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/04	2014/10/16	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	rogid:Jmojsmx7uQfFInaExASOKFttPFk9606	intact-crc:13EAD564670FC08D|rigid:DtvGhEVCBmLTfHPis5cgG5lD46Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78552	uniprotkb:P35225	intact:EBI-1391535|uniprotkb:O95646|uniprotkb:Q99656|intact:EBI-3918927|uniprotkb:Q5JSL4|uniprotkb:Q9UDY5|ensembl:ENSP00000360730	intact:EBI-1647828|uniprotkb:O43644|uniprotkb:Q4VB52|uniprotkb:Q9UDC7|ensembl:ENSP00000304915	psi-mi:i13r1_human(display_long)|uniprotkb:Cancer/testis antigen 19(gene name synonym)|uniprotkb:IL13RA1(gene name)|psi-mi:IL13RA1(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:IL13RA(gene name synonym)	psi-mi:il13_human(display_long)|uniprotkb:IL13(gene name)|psi-mi:IL13(display_short)|uniprotkb:NC30(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	LaPorte et al. (2008)	imex:IM-12023|pubmed:18243101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1647871|imex:IM-12023-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001551.1|dip:DIP-3225N|ensembl:ENSG00000131724(gene)|interpro:IPR036116|interpro:IPR040566|rcsb pdb:3BPN|ensembl:ENST00000371666(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005898"(interleukin-13 receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|rcsb pdb:3BPO|rcsb pdb:4HWB|rcsb pdb:5E4E|reactome:R-HSA-6785807	refseq:NP_002179.2|dip:DIP-3224N|ensembl:ENSG00000169194(gene)|ensembl:ENST00000304506(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045471"(response to ethanol)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901247"(negative regulation of lung ciliated cell differentiation)|go:"GO:1901251"(positive regulation of lung goblet cell differentiation)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470|rcsb pdb:1GA3|rcsb pdb:1IJZ|rcsb pdb:1IK0|rcsb pdb:1J9U|rcsb pdb:3BPO|rcsb pdb:3G6D|rcsb pdb:3ITR|rcsb pdb:3ITS|rcsb pdb:3L5W|rcsb pdb:3L5X|rcsb pdb:3LB6|rcsb pdb:4I77|rcsb pdb:4PS4|rcsb pdb:5E4E|rcsb pdb:5L6Y|reactome:R-HSA-6785807|reactome:R-HSA-9012546	psi-mi:"MI:0469"(intact)	-	-	figure legend:3 C, Table S3|kinetics:Kd for IL-13 binding to IL-13Ralpha1 = 3.0 E-8 M|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/04	2014/10/16	rogid:EufIBLLPq2hkBrfc1evg9tTfp1o9606	rogid:NORPxfYHTfYxQaFWP3FFlC76bWE9606	intact-crc:1E267BE1DB7AA2FB|rigid:Z1zIbPxztQp3LG7UOVwxlKhUFMk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)