#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9BXW9 uniprotkb:P51587 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1638729|imex:IM-14933-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N psi-mi:"MI:0469"(intact) - - figure legend:1 A, 2B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2008/02/18 2015/12/03 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 intact-crc:E99E68F09FA6376F|rigid:V3gUV91kco1F4NDQoxfBVXS8kA8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXW9 uniprotkb:P51587 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1638779|imex:IM-14933-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N psi-mi:"MI:0469"(intact) - - figure legend:1 A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-3a_tpa_30_1)|taxid:9606("Homo sapiens 3A(tPA-30-1) cell line") - 2008/02/18 2015/12/03 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 intact-crc:310C0BFE12CD7317|rigid:V3gUV91kco1F4NDQoxfBVXS8kA8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXW9 uniprotkb:P51587 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1638822|imex:IM-14933-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N psi-mi:"MI:0469"(intact) - - figure legend:1 A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-bd220)|taxid:9606("Homo sapiens Fanconi anaemia cell line BD220 (FA-A)") - 2008/02/18 2015/12/03 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 intact-crc:CD7ABA0A3D222CFC|rigid:V3gUV91kco1F4NDQoxfBVXS8kA8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P51587 uniprotkb:Q9BXW9 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639921|imex:IM-14933-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N psi-mi:"MI:0469"(intact) - - figure legend:2 C|comment:Only the FANCD2-S isoform coimmunoprecipitates with BRCA2 in this FA-A cell line.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-bd220)|taxid:9606("Homo sapiens Fanconi anaemia cell line BD220 (FA-A)") - 2008/02/18 2015/12/03 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 intact-crc:62533F7B7C8377AC|rigid:V3gUV91kco1F4NDQoxfBVXS8kA8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXW9 uniprotkb:P51587 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1638837|imex:IM-14933-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N psi-mi:"MI:0469"(intact) - - figure legend:1 A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-bd215)|taxid:9606("Homo sapiens Fanconi anaemia cell lines BD215 (FA-C)") - 2008/02/18 2015/12/03 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 intact-crc:B04EA2BEE2D5FCC0|rigid:V3gUV91kco1F4NDQoxfBVXS8kA8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P51587 uniprotkb:Q9BXW9 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639932|imex:IM-14933-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N psi-mi:"MI:0469"(intact) - - figure legend:2 C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-bd215)|taxid:9606("Homo sapiens Fanconi anaemia cell lines BD215 (FA-C)") - 2008/02/18 2015/12/03 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 intact-crc:93DC75E540F629D4|rigid:V3gUV91kco1F4NDQoxfBVXS8kA8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P51587 uniprotkb:Q9BXW9 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1638859|imex:IM-14933-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N psi-mi:"MI:0469"(intact) - - figure legend:1 A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-eufa409)|taxid:9606("Homo sapiens Fanconi anaemia cell lines EUFA409 (FA-E)") - 2008/02/18 2015/12/03 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 intact-crc:B128EBA3873CA18A|rigid:V3gUV91kco1F4NDQoxfBVXS8kA8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXW9 uniprotkb:P51587 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639937|imex:IM-14933-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N psi-mi:"MI:0469"(intact) - - figure legend:2 C|comment:Only the FANCD2-S isoform coimmunoprecipitated with BRCA2 in the FA-E cell line.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-eufa409)|taxid:9606("Homo sapiens Fanconi anaemia cell lines EUFA409 (FA-E)") - 2008/02/18 2015/12/03 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 intact-crc:48F70BF47D6DCE69|rigid:V3gUV91kco1F4NDQoxfBVXS8kA8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P51587 uniprotkb:Q9BXW9 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1638874|imex:IM-14933-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N psi-mi:"MI:0469"(intact) - - figure legend:1 A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-eufa121)|taxid:9606("Homo sapiens Fanconi anaemia cell lines EUFA121 (FA-F)") - 2008/02/18 2015/12/03 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 intact-crc:FCAEED7622E2DDEF|rigid:V3gUV91kco1F4NDQoxfBVXS8kA8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P51587 uniprotkb:Q9BXW9 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639943|imex:IM-14933-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N psi-mi:"MI:0469"(intact) - - figure legend:2 C|comment:Only the FANCD2-S isoform coimmunoprecipitated with BRCA2 in theis FA-F cell line.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-eufa121)|taxid:9606("Homo sapiens Fanconi anaemia cell lines EUFA121 (FA-F)") - 2008/02/18 2015/12/03 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 intact-crc:0D80C403259EF8F3|rigid:V3gUV91kco1F4NDQoxfBVXS8kA8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXW9 uniprotkb:O15287 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 intact:EBI-81610|ensembl:ENSP00000367910 psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:fancg_human(display_long)|uniprotkb:FANCG(gene name)|psi-mi:FANCG(display_short)|uniprotkb:XRCC9(gene name synonym)|uniprotkb:DNA repair protein XRCC9(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639686|imex:IM-14933-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N ensembl:ENSG00000221829(gene)|refseq:NP_004620.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007286"(spermatid development)|go:"GO:0009314"(response to radiation)|ensembl:ENST00000378643(transcript)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039684|mint:O15287|rcsb pdb:7KZP|rcsb pdb:7KZQ|go:"GO:0001541"(ovarian follicle development)|rcsb pdb:7KZR|go:"GO:0003684"(damaged DNA binding)|rcsb pdb:7KZS|go:"GO:0005654"(nucleoplasm)|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|go:"GO:0005730"(nucleolus) psi-mi:"MI:0469"(intact) - - figure legend:1 B|comment:Introduction of wild-type FANCG restored the interaction of FANCD2-BRCA2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-326v)|taxid:9606("Homo sapiens Fanconi anaemia fibroblast cell line 326V (FA-G)") - 2008/02/18 2015/12/03 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 rogid:jVGeic2vn/qrZgro3IKXWhNteHo9606 intact-crc:27292C4149FA0464|rigid:v8O40dRYdX58fsx9Ym4tV4MUfm8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXW9 uniprotkb:P51587 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639686|imex:IM-14933-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N psi-mi:"MI:0469"(intact) - - figure legend:1 B|comment:Introduction of wild-type FANCG restored the interaction of FANCD2-BRCA2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-326v)|taxid:9606("Homo sapiens Fanconi anaemia fibroblast cell line 326V (FA-G)") - 2008/02/18 2015/12/03 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 intact-crc:27292C4149FA0464|rigid:v8O40dRYdX58fsx9Ym4tV4MUfm8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXW9 uniprotkb:O15287 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 intact:EBI-81610|ensembl:ENSP00000367910 psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:fancg_human(display_long)|uniprotkb:FANCG(gene name)|psi-mi:FANCG(display_short)|uniprotkb:XRCC9(gene name synonym)|uniprotkb:DNA repair protein XRCC9(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639712|imex:IM-14933-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N ensembl:ENSG00000221829(gene)|refseq:NP_004620.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007286"(spermatid development)|go:"GO:0009314"(response to radiation)|ensembl:ENST00000378643(transcript)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039684|mint:O15287|rcsb pdb:7KZP|rcsb pdb:7KZQ|go:"GO:0001541"(ovarian follicle development)|rcsb pdb:7KZR|go:"GO:0003684"(damaged DNA binding)|rcsb pdb:7KZS|go:"GO:0005654"(nucleoplasm)|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|go:"GO:0005730"(nucleolus) psi-mi:"MI:0469"(intact) - - figure legend:1 B, 2 B, 3 B|comment:Introduction of wild-type FANCG restored the interaction of FANCD2-BRCA2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-eufa143)|taxid:9606("Homo sapiens Fanconi anaemia lymphoblast cell line EUFA143 (FA-G)") - 2008/02/18 2015/12/03 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 rogid:jVGeic2vn/qrZgro3IKXWhNteHo9606 intact-crc:373CEAB57AA66DD9|rigid:v8O40dRYdX58fsx9Ym4tV4MUfm8 false - mutation disrupting interaction strength:7-7 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXW9 uniprotkb:P51587 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639712|imex:IM-14933-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N psi-mi:"MI:0469"(intact) - - figure legend:1 B, 2 B, 3 B|comment:Introduction of wild-type FANCG restored the interaction of FANCD2-BRCA2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-eufa143)|taxid:9606("Homo sapiens Fanconi anaemia lymphoblast cell line EUFA143 (FA-G)") - 2008/02/18 2015/12/03 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 intact-crc:373CEAB57AA66DD9|rigid:v8O40dRYdX58fsx9Ym4tV4MUfm8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G3GX36 uniprotkb:O15287 intact:EBI-1639774 intact:EBI-81610|ensembl:ENSP00000367910 psi-mi:g3gx36_crigr(display_long)|uniprotkb:I79_002348(orf name) psi-mi:fancg_human(display_long)|uniprotkb:FANCG(gene name)|psi-mi:FANCG(display_short)|uniprotkb:XRCC9(gene name synonym)|uniprotkb:DNA repair protein XRCC9(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639769|imex:IM-14933-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016024(Armadillo-type fold)|interpro:IPR029448|go:"GO:0006281"(DNA repair) ensembl:ENSG00000221829(gene)|refseq:NP_004620.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007286"(spermatid development)|go:"GO:0009314"(response to radiation)|ensembl:ENST00000378643(transcript)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039684|mint:O15287|rcsb pdb:7KZP|rcsb pdb:7KZQ|go:"GO:0001541"(ovarian follicle development)|rcsb pdb:7KZR|go:"GO:0003684"(damaged DNA binding)|rcsb pdb:7KZS|go:"GO:0005654"(nucleoplasm)|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|go:"GO:0005730"(nucleolus) psi-mi:"MI:0469"(intact) - - figure legend:1 B, 3 A|comment:Introduction of wild-type FANCG restored the interaction of FANCD2-BRCA2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-nm3)|taxid:10029(Cricetulus griseus - CHO derived cell line NM3 harbouring a mutation in FANCG) - 2008/02/18 2014/10/16 rogid:45nHWJWlhhY5PlijOCJUVnA1My010029 rogid:jVGeic2vn/qrZgro3IKXWhNteHo9606 intact-crc:FD049F3480255DCF|rigid:gB1fYNxKFPJo5TNBs0YWAbTZxwc false - mutation disrupting interaction strength:7-7 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G3GX36 uniprotkb:Q8R4X4 intact:EBI-1639774 intact:EBI-1639762 psi-mi:g3gx36_crigr(display_long)|uniprotkb:I79_002348(orf name) psi-mi:q8r4x4_crigr(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639769|imex:IM-14933-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016024(Armadillo-type fold)|interpro:IPR029448|go:"GO:0006281"(DNA repair) interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR002093(BRCA2 repeat)|go:"GO:0000724"(double-strand break repair via homologous recombination) psi-mi:"MI:0469"(intact) - - figure legend:1 B, 3 A|comment:Introduction of wild-type FANCG restored the interaction of FANCD2-BRCA2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-nm3)|taxid:10029(Cricetulus griseus - CHO derived cell line NM3 harbouring a mutation in FANCG) - 2008/02/18 2014/10/16 rogid:45nHWJWlhhY5PlijOCJUVnA1My010029 rogid:8TY8yRMwtBsfFt0MWLXW+hobsT410029 intact-crc:FD049F3480255DCF|rigid:gB1fYNxKFPJo5TNBs0YWAbTZxwc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXW9-2 uniprotkb:P51587 intact:EBI-596878|ensembl:ENSP00000398754|ensembl:ENSP00000502379 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 psi-mi:q9bxw9-2(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639805|imex:IM-14933-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-359343(facd2_human)|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|uniprotkb:Q9BXW9-2(isoform-parent) ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N psi-mi:"MI:0469"(intact) isoform-comment:Contains a phosphoserine at position 1423. Contains a phosphothreonine at position 1426. Contains a phosphoserine at position 1435. - figure legend:2 B|delivery method:Q9BXW9 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pd20)|taxid:9606("Homo sapiens Fanconi anaemia cell line PD20 (FA-D2)") - 2008/02/18 2015/12/03 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 intact-crc:543B79FFECCDF8CC|rigid:V3gUV91kco1F4NDQoxfBVXS8kA8 false mutation:561-561 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P51587 uniprotkb:Q9BXW9 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639813|imex:IM-14933-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N psi-mi:"MI:0469"(intact) - - figure legend:2 B|comment:This interaction occurred in cells functionally complemented with human chromosome 3p.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pd20)|taxid:9606("Homo sapiens Fanconi anaemia cell line PD20 (FA-D2)") - 2008/02/18 2015/12/03 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 intact-crc:C01A95E6E45AFEA1|rigid:V3gUV91kco1F4NDQoxfBVXS8kA8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P51587 uniprotkb:Q9BXW9-2 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 intact:EBI-596878|ensembl:ENSP00000398754|ensembl:ENSP00000502379 psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:q9bxw9-2(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639830|imex:IM-14933-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N intact:EBI-359343(facd2_human)|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|uniprotkb:Q9BXW9-2(isoform-parent) psi-mi:"MI:0469"(intact) - isoform-comment:Contains a phosphoserine at position 1423. Contains a phosphothreonine at position 1426. Contains a phosphoserine at position 1435. figure legend:2 B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hcs72)|taxid:9606("Homo sapiens Fanconi anaemia cell line HCS72 (FA-A)") - 2008/02/18 2015/12/03 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 intact-crc:88AD7E8A74D1D0B9|rigid:V3gUV91kco1F4NDQoxfBVXS8kA8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P51587 uniprotkb:Q9BXW9-2 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 intact:EBI-596878|ensembl:ENSP00000398754|ensembl:ENSP00000502379 psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:q9bxw9-2(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639927|imex:IM-14933-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N intact:EBI-359343(facd2_human)|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|uniprotkb:Q9BXW9-2(isoform-parent) psi-mi:"MI:0469"(intact) - isoform-comment:Contains a phosphoserine at position 1423. Contains a phosphothreonine at position 1426. Contains a phosphoserine at position 1435. figure legend:2 C|comment:Only the FANCD2-S isoform coimmunoprecipitates with BRCA2 in this FA-A cell line.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hcs72)|taxid:9606("Homo sapiens Fanconi anaemia cell line HCS72 (FA-A)") - 2008/02/18 2015/12/03 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 intact-crc:98AA08D60A0A45E4|rigid:V3gUV91kco1F4NDQoxfBVXS8kA8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G3GX36 uniprotkb:Q8R4X4 intact:EBI-1639774 intact:EBI-1639762 psi-mi:g3gx36_crigr(display_long)|uniprotkb:I79_002348(orf name) psi-mi:q8r4x4_crigr(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639855|imex:IM-14933-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016024(Armadillo-type fold)|interpro:IPR029448|go:"GO:0006281"(DNA repair) interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR002093(BRCA2 repeat)|go:"GO:0000724"(double-strand break repair via homologous recombination) psi-mi:"MI:0469"(intact) - - figure legend:2 C, 3 A|comment:The two isoforms of FANCD2, FANCD2-L and FANCD2-S, were co-precipitated with BRCA2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-aa8)|taxid:10029("Cricetulus griseus AA8 cell line (derived from CHO-K1)") - 2008/02/18 2021/06/24 rogid:45nHWJWlhhY5PlijOCJUVnA1My010029 rogid:8TY8yRMwtBsfFt0MWLXW+hobsT410029 intact-crc:71FF60E0945045DC|rigid:mTVV0nhB/fIt2JVnPPsRfej4JM8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G3GX36 uniprotkb:Q8R4X4 intact:EBI-1639774 intact:EBI-1639762 psi-mi:g3gx36_crigr(display_long)|uniprotkb:I79_002348(orf name) psi-mi:q8r4x4_crigr(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639884|imex:IM-14933-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016024(Armadillo-type fold)|interpro:IPR029448|go:"GO:0006281"(DNA repair) interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR002093(BRCA2 repeat)|go:"GO:0000724"(double-strand break repair via homologous recombination) psi-mi:"MI:0469"(intact) - - figure legend:2 C|comment:The two isoforms of FANCD2, FANCD2-L and FANCD2-S, were co-precipitated with BRCA2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-v79)|taxid:10029(Cricetulus griseus lung fibroblast V79 cell line) - 2008/02/18 2021/06/24 rogid:45nHWJWlhhY5PlijOCJUVnA1My010029 rogid:8TY8yRMwtBsfFt0MWLXW+hobsT410029 intact-crc:DD3E22872D183B53|rigid:mTVV0nhB/fIt2JVnPPsRfej4JM8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G3GX36 uniprotkb:Q8R4X4 intact:EBI-1639774 intact:EBI-1639762 psi-mi:g3gx36_crigr(display_long)|uniprotkb:I79_002348(orf name) psi-mi:q8r4x4_crigr(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639788|imex:IM-14933-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016024(Armadillo-type fold)|interpro:IPR029448|go:"GO:0006281"(DNA repair) interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR002093(BRCA2 repeat)|go:"GO:0000724"(double-strand break repair via homologous recombination) psi-mi:"MI:0469"(intact) - - figure legend:1 B, 3 A|comment:Introduction of wild-type FANCG restored the interaction of FANCD2-BRCA2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-40bp6)|taxid:10029("Cricetulus griseus ovary derived cells (FANCG-corrected)") - 2008/02/18 2014/10/16 rogid:45nHWJWlhhY5PlijOCJUVnA1My010029 rogid:8TY8yRMwtBsfFt0MWLXW+hobsT410029 intact-crc:CB9267E9806BE025|rigid:mTVV0nhB/fIt2JVnPPsRfej4JM8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8R4X4 uniprotkb:G3GX36 intact:EBI-1639762 intact:EBI-1639774 psi-mi:q8r4x4_crigr(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short) psi-mi:g3gx36_crigr(display_long)|uniprotkb:I79_002348(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639901|imex:IM-14933-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR002093(BRCA2 repeat)|go:"GO:0000724"(double-strand break repair via homologous recombination) interpro:IPR016024(Armadillo-type fold)|interpro:IPR029448|go:"GO:0006281"(DNA repair) psi-mi:"MI:0469"(intact) - - figure legend:2 C|comment:The two isoforms of FANCD2, FANCD2-L and FANCD2-S, were co-precipitated with BRCA2.|comment:The reintroduction of FANCG restores this interacton.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-40bp6)|taxid:10029("Cricetulus griseus ovary derived cells (FANCG-corrected)") - 2008/02/18 2014/10/16 rogid:8TY8yRMwtBsfFt0MWLXW+hobsT410029 rogid:45nHWJWlhhY5PlijOCJUVnA1My010029 intact-crc:8FD77836D7DC5CAA|rigid:mTVV0nhB/fIt2JVnPPsRfej4JM8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P51587 uniprotkb:Q9BXW9 intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym) psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wilson et al. (2008) imex:IM-14933|pubmed:18212739 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1639971|imex:IM-14933-22 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N psi-mi:"MI:0469"(intact) - - figure legend:2 B, 3 B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-bd180)|taxid:9606(Homo sapiens BD180 cell line) - 2008/02/18 2015/12/03 rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 intact-crc:401B557721F507E2|rigid:V3gUV91kco1F4NDQoxfBVXS8kA8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)