#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96AV8	uniprotkb:A0AVK6	intact:EBI-1386765|uniprotkb:B3KUP8|uniprotkb:A6NC74|uniprotkb:B2RMR7|uniprotkb:B3KTZ5|uniprotkb:B5MED9|ensembl:ENSP00000323246	intact:EBI-7779316|ensembl:ENSP00000250024|ensembl:ENSP00000434199|ensembl:ENSP00000481103|uniprotkb:Q8N340|uniprotkb:Q5BKY4|intact:MINT-6541611|uniprotkb:Q9H5M0|uniprotkb:Q3C1U6|uniprotkb:Q2VPJ3|uniprotkb:A8K9H3	psi-mi:e2f7_human(display_long)|uniprotkb:E2F7(gene name)|psi-mi:E2F7(display_short)	psi-mi:e2f8_human(display_long)|uniprotkb:E2F8(gene name)|psi-mi:E2F8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zalmas et al. (2008)	pubmed:18202719|imex:IM-11566|mint:MINT-6541585	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7779310|mint:MINT-6541625|imex:IM-11566-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_976328.2|ensembl:ENSG00000165891(gene)|ensembl:ENST00000322886(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032877"(positive regulation of DNA endoreduplication)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR036388|interpro:IPR036390|mint:Q96AV8|reactome:R-HSA-6804116|mint:MINT-6541627(identity)	go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR036388|interpro:IPR036390|mint:A0AVK6|rcsb pdb:4YO2|reactome:R-HSA-6804116|go:"GO:0070365"(hepatocyte differentiation)|ensembl:ENSG00000129173(gene)|ensembl:ENST00000250024(transcript)|ensembl:ENST00000527884(transcript)|ensembl:ENST00000620009(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001890"(placenta development)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032877"(positive regulation of DNA endoreduplication)|go:"GO:0033301"(cell cycle comprising mitosis without cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|refseq:NP_001243301.1|refseq:NP_001243300.1|refseq:NP_078956.2|mint:MINT-6541628(identity)	-	-	function:Inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession. Modulates the activity of other E2F proteins, such as E2F1, probably by competing or displacing activating E2Fs from promoter binding|comment:mint	figure legend:f3b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2008/05/09	2014/10/16	rogid:QyyGEJfgxGZZogHf4jQ06CI9ioc9606	rogid:8RCzz+HuzFPNJ4soR6lxKkq17BU9606	intact-crc:75604BDACED1CC61|rigid:+h2+Aee3o0MYwBEMho2nQfOasNM	false	flag tag:?-?(MINT-6541634)	myc tag:?-?(MINT-6541630)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96AV8	uniprotkb:A0AVK6	intact:EBI-1386765|uniprotkb:B3KUP8|uniprotkb:A6NC74|uniprotkb:B2RMR7|uniprotkb:B3KTZ5|uniprotkb:B5MED9|ensembl:ENSP00000323246	intact:EBI-7779316|ensembl:ENSP00000250024|ensembl:ENSP00000434199|ensembl:ENSP00000481103|uniprotkb:Q8N340|uniprotkb:Q5BKY4|intact:MINT-6541611|uniprotkb:Q9H5M0|uniprotkb:Q3C1U6|uniprotkb:Q2VPJ3|uniprotkb:A8K9H3	psi-mi:e2f7_human(display_long)|uniprotkb:E2F7(gene name)|psi-mi:E2F7(display_short)	psi-mi:e2f8_human(display_long)|uniprotkb:E2F8(gene name)|psi-mi:E2F8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zalmas et al. (2008)	pubmed:18202719|imex:IM-11566|mint:MINT-6541585	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7779394|mint:MINT-6541638|imex:IM-11566-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_976328.2|ensembl:ENSG00000165891(gene)|ensembl:ENST00000322886(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032877"(positive regulation of DNA endoreduplication)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR036388|interpro:IPR036390|mint:Q96AV8|reactome:R-HSA-6804116|mint:MINT-6541640(identity)	go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR036388|interpro:IPR036390|mint:A0AVK6|rcsb pdb:4YO2|reactome:R-HSA-6804116|go:"GO:0070365"(hepatocyte differentiation)|ensembl:ENSG00000129173(gene)|ensembl:ENST00000250024(transcript)|ensembl:ENST00000527884(transcript)|ensembl:ENST00000620009(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001890"(placenta development)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032877"(positive regulation of DNA endoreduplication)|go:"GO:0033301"(cell cycle comprising mitosis without cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|refseq:NP_001243301.1|refseq:NP_001243300.1|refseq:NP_078956.2|mint:MINT-6541644(identity)	-	-	function:Inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession. Modulates the activity of other E2F proteins, such as E2F1, probably by competing or displacing activating E2Fs from promoter binding|comment:mint	figure legend:f3c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2008/05/09	2014/10/16	rogid:QyyGEJfgxGZZogHf4jQ06CI9ioc9606	rogid:8RCzz+HuzFPNJ4soR6lxKkq17BU9606	intact-crc:3E5F6B57DD4B295D|rigid:+h2+Aee3o0MYwBEMho2nQfOasNM	false	ha tag:?-?(MINT-6541641)|mutation disrupting interaction:340-342,191-194(MINT-6541661)	mutation disrupting interaction:162-165,320-322(MINT-6541651)|myc tag:?-?(MINT-6541645)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96AV8	uniprotkb:A0AVK6	intact:EBI-1386765|uniprotkb:B3KUP8|uniprotkb:A6NC74|uniprotkb:B2RMR7|uniprotkb:B3KTZ5|uniprotkb:B5MED9|ensembl:ENSP00000323246	intact:EBI-7779316|ensembl:ENSP00000250024|ensembl:ENSP00000434199|ensembl:ENSP00000481103|uniprotkb:Q8N340|uniprotkb:Q5BKY4|intact:MINT-6541611|uniprotkb:Q9H5M0|uniprotkb:Q3C1U6|uniprotkb:Q2VPJ3|uniprotkb:A8K9H3	psi-mi:e2f7_human(display_long)|uniprotkb:E2F7(gene name)|psi-mi:E2F7(display_short)	psi-mi:e2f8_human(display_long)|uniprotkb:E2F8(gene name)|psi-mi:E2F8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zalmas et al. (2008)	pubmed:18202719|imex:IM-11566|mint:MINT-6541585	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7779430|mint:MINT-6541666|imex:IM-11566-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_976328.2|ensembl:ENSG00000165891(gene)|ensembl:ENST00000322886(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032877"(positive regulation of DNA endoreduplication)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR036388|interpro:IPR036390|mint:Q96AV8|reactome:R-HSA-6804116|mint:MINT-6541668(identity)	go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR036388|interpro:IPR036390|mint:A0AVK6|rcsb pdb:4YO2|reactome:R-HSA-6804116|go:"GO:0070365"(hepatocyte differentiation)|ensembl:ENSG00000129173(gene)|ensembl:ENST00000250024(transcript)|ensembl:ENST00000527884(transcript)|ensembl:ENST00000620009(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001890"(placenta development)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032877"(positive regulation of DNA endoreduplication)|go:"GO:0033301"(cell cycle comprising mitosis without cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|refseq:NP_001243301.1|refseq:NP_001243300.1|refseq:NP_078956.2|mint:MINT-6541675(identity)	-	-	function:Inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession. Modulates the activity of other E2F proteins, such as E2F1, probably by competing or displacing activating E2Fs from promoter binding|comment:mint	figure legend:f3d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2008/05/09	2014/10/16	rogid:QyyGEJfgxGZZogHf4jQ06CI9ioc9606	rogid:8RCzz+HuzFPNJ4soR6lxKkq17BU9606	intact-crc:4F2DB0D49C71CF24|rigid:+h2+Aee3o0MYwBEMho2nQfOasNM	false	ha tag:?-?(MINT-6541672)|mutation disrupting interaction:340-342,191-194(MINT-6541669)	myc tag:?-?(MINT-6541679)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96AV8	uniprotkb:A0AVK6	intact:EBI-1386765|uniprotkb:B3KUP8|uniprotkb:A6NC74|uniprotkb:B2RMR7|uniprotkb:B3KTZ5|uniprotkb:B5MED9|ensembl:ENSP00000323246	intact:EBI-7779316|ensembl:ENSP00000250024|ensembl:ENSP00000434199|ensembl:ENSP00000481103|uniprotkb:Q8N340|uniprotkb:Q5BKY4|intact:MINT-6541611|uniprotkb:Q9H5M0|uniprotkb:Q3C1U6|uniprotkb:Q2VPJ3|uniprotkb:A8K9H3	psi-mi:e2f7_human(display_long)|uniprotkb:E2F7(gene name)|psi-mi:E2F7(display_short)	psi-mi:e2f8_human(display_long)|uniprotkb:E2F8(gene name)|psi-mi:E2F8(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zalmas et al. (2008)	pubmed:18202719|imex:IM-11566|mint:MINT-6541585	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7779517|mint:MINT-6541689|imex:IM-11566-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_976328.2|ensembl:ENSG00000165891(gene)|ensembl:ENST00000322886(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032877"(positive regulation of DNA endoreduplication)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR036388|interpro:IPR036390|mint:Q96AV8|reactome:R-HSA-6804116|mint:MINT-6541691(identity)	go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR036388|interpro:IPR036390|mint:A0AVK6|rcsb pdb:4YO2|reactome:R-HSA-6804116|go:"GO:0070365"(hepatocyte differentiation)|ensembl:ENSG00000129173(gene)|ensembl:ENST00000250024(transcript)|ensembl:ENST00000527884(transcript)|ensembl:ENST00000620009(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001890"(placenta development)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032877"(positive regulation of DNA endoreduplication)|go:"GO:0033301"(cell cycle comprising mitosis without cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|refseq:NP_001243301.1|refseq:NP_001243300.1|refseq:NP_078956.2|mint:MINT-6541695(identity)	-	-	function:Inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession. Modulates the activity of other E2F proteins, such as E2F1, probably by competing or displacing activating E2Fs from promoter binding|comment:mint	figure legend:f3b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/05/09	2014/10/16	rogid:QyyGEJfgxGZZogHf4jQ06CI9ioc9606	rogid:8RCzz+HuzFPNJ4soR6lxKkq17BU9606	intact-crc:3F860DA7F3EEBC52|rigid:+h2+Aee3o0MYwBEMho2nQfOasNM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)