#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P12866	uniprotkb:P62990	intact:EBI-18383|uniprotkb:D6VWZ4|ensemblfungi:YKL209C	intact:EBI-413053|uniprotkb:Q28170|uniprotkb:Q29120|uniprotkb:O97577|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:P80169|uniprotkb:Q01235|uniprotkb:Q24K23|uniprotkb:Q28169|uniprotkb:Q3ZCE3|uniprotkb:Q862C1|uniprotkb:Q862F4|uniprotkb:Q862M4|uniprotkb:Q862T5|uniprotkb:Q862X8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q3T0V5|dip:DIP-29049N	psi-mi:ste6_yeast(display_long)|uniprotkb:STE6(gene name)|psi-mi:STE6(display_short)|uniprotkb:Multiple drug resistance protein homolog(gene name synonym)|uniprotkb:P-glycoprotein(gene name synonym)|uniprotkb:Mating factor A secretion protein STE6(gene name synonym)|uniprotkb:YKL209C(locus name)	psi-mi:ubiq_bovin(display_long)|uniprotkb:RPS27A(gene name)|psi-mi:RPS27A(display_short)|uniprotkb:UBA80(gene name synonym)|uniprotkb:UBCEP1(gene name synonym)|uniprotkb:UBA52(gene name)|psi-mi:UBA52(display_short)|uniprotkb:UBCEP2(gene name synonym)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)|uniprotkb:UBC(gene name)|psi-mi:UBC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakatsukasa et al. (2008)	imex:IM-11874|pubmed:18191224	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1637241|imex:IM-11874-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012713.1|sgd:S000001692|ensemblfungi:YKL209C(gene)|ensemblfungi:YKL209C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000770"(peptide pheromone export)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019236"(response to pheromone)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043332"(mating projection tip)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030246|interpro:IPR036640|reactome:R-SCE-382556|dip:DIP-2594N|mint:P12866	interpro:IPR000626(Ubiquitin)|refseq:NP_001069831.1|refseq:NP_777203.1|refseq:NP_776558.1|rcsb pdb:2QHO|rcsb pdb:2ZCC|ensembl:ENSBTAG00000015473|ensembl:ENSBTAG00000017246|rcsb pdb:1E0Q|rcsb pdb:2HD5|rcsb pdb:2OOB|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|rcsb pdb:3H1U|go:"GO:0005515"(protein binding)|go:"GO:0030528"(obsolete transcription regulator activity)|go:"GO:0045941"|go:"GO:0016567"(protein ubiquitination)|ensembl:ENSBTAG00000007737|rcsb pdb:1AAR|rcsb pdb:1P3Q|rcsb pdb:1UZX|rcsb pdb:1V80|rcsb pdb:1V81|rcsb pdb:1WR6|rcsb pdb:1WRD|rcsb pdb:1YD8|rcsb pdb:2C7M|rcsb pdb:2C7N|rcsb pdb:2D3G|rcsb pdb:2DX5|rcsb pdb:2FID|rcsb pdb:2FIF|go:"GO:0005634"(nucleus)|ipi:IPI00687665|rcsb pdb:2WWZ|rcsb pdb:2WX0|rcsb pdb:2WX1	go:"GO:0005792"(obsolete microsome)	crc64:B240B7E51D9680D5	-	delivery method:P12866 transfection|figure legend:Figs. 1, 2, 3C, 4C, 5D, 6B, 6E|antagonist:Methylated ubiquitin|comment:Microsomes lacking Ubc6 and Ubc7 failed to support Ste6 ubiquitination. Microsomes lacking Doa10 or Hrd1 supported Ste6 ubiquitination, whereas  deletion of both these genes inhibited ubiquitination. Ssa1 and Ydj1/Hlj1 chaperones facilitate substrate ubiquitination|comment:Ubiquitination increases the amount of Ste6 which appears in the cytoplasm. Ubiquitinated Ste6 disappeared over time, but degradation was slowed upon the addition of proteasome inhibitors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/11	2014/10/16	rogid:G3ZhCo+dInWlxMbhtTagcCyAbXI559292	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9913	intact-crc:4C331CC80165E574|rigid:qx4O0tj/fDEUdkwSLA7UTJ/Ezew	false	ha tag:?-?	125i radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P25694	uniprotkb:P62990	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	intact:EBI-413053|uniprotkb:Q28170|uniprotkb:Q29120|uniprotkb:O97577|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:P80169|uniprotkb:Q01235|uniprotkb:Q24K23|uniprotkb:Q28169|uniprotkb:Q3ZCE3|uniprotkb:Q862C1|uniprotkb:Q862F4|uniprotkb:Q862M4|uniprotkb:Q862T5|uniprotkb:Q862X8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q3T0V5|dip:DIP-29049N	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:ubiq_bovin(display_long)|uniprotkb:RPS27A(gene name)|psi-mi:RPS27A(display_short)|uniprotkb:UBA80(gene name synonym)|uniprotkb:UBCEP1(gene name synonym)|uniprotkb:UBA52(gene name)|psi-mi:UBA52(display_short)|uniprotkb:UBCEP2(gene name synonym)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)|uniprotkb:UBC(gene name)|psi-mi:UBC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakatsukasa et al. (2008)	imex:IM-11874|pubmed:18191224	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1637399|imex:IM-11874-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	interpro:IPR000626(Ubiquitin)|refseq:NP_001069831.1|refseq:NP_777203.1|refseq:NP_776558.1|rcsb pdb:2QHO|rcsb pdb:2ZCC|ensembl:ENSBTAG00000015473|ensembl:ENSBTAG00000017246|rcsb pdb:1E0Q|rcsb pdb:2HD5|rcsb pdb:2OOB|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|rcsb pdb:3H1U|go:"GO:0005515"(protein binding)|go:"GO:0030528"(obsolete transcription regulator activity)|go:"GO:0045941"|go:"GO:0016567"(protein ubiquitination)|ensembl:ENSBTAG00000007737|rcsb pdb:1AAR|rcsb pdb:1P3Q|rcsb pdb:1UZX|rcsb pdb:1V80|rcsb pdb:1V81|rcsb pdb:1WR6|rcsb pdb:1WRD|rcsb pdb:1YD8|rcsb pdb:2C7M|rcsb pdb:2C7N|rcsb pdb:2D3G|rcsb pdb:2DX5|rcsb pdb:2FID|rcsb pdb:2FIF|go:"GO:0005634"(nucleus)|ipi:IPI00687665|rcsb pdb:2WWZ|rcsb pdb:2WX0|rcsb pdb:2WX1	go:"GO:0005792"(obsolete microsome)	crc64:02ADDB9A227614D8	-	delivery method:P12866; P25694 transfection|figure legend:Fig. 6C|comment:The immunocomplex was subjected to two rounds of immunoprecipitation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/11	2014/10/16	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9913	intact-crc:C958C86CB466F7A1|rigid:wc5o/SZJOkIQ0nBzqGt9wBo+JKE	false	calmodulin binding peptide plus protein a tag:?-?	125i radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P25694	uniprotkb:P12866	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	intact:EBI-18383|uniprotkb:D6VWZ4|ensemblfungi:YKL209C	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:ste6_yeast(display_long)|uniprotkb:STE6(gene name)|psi-mi:STE6(display_short)|uniprotkb:Multiple drug resistance protein homolog(gene name synonym)|uniprotkb:P-glycoprotein(gene name synonym)|uniprotkb:Mating factor A secretion protein STE6(gene name synonym)|uniprotkb:YKL209C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakatsukasa et al. (2008)	imex:IM-11874|pubmed:18191224	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1637399|imex:IM-11874-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	refseq:NP_012713.1|sgd:S000001692|ensemblfungi:YKL209C(gene)|ensemblfungi:YKL209C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000770"(peptide pheromone export)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019236"(response to pheromone)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043332"(mating projection tip)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030246|interpro:IPR036640|reactome:R-SCE-382556|dip:DIP-2594N|mint:P12866	go:"GO:0005792"(obsolete microsome)	crc64:02ADDB9A227614D8	crc64:B240B7E51D9680D5	delivery method:P12866; P25694 transfection|figure legend:Fig. 6C|comment:The immunocomplex was subjected to two rounds of immunoprecipitation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/11	2014/10/16	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	rogid:G3ZhCo+dInWlxMbhtTagcCyAbXI559292	intact-crc:C958C86CB466F7A1|rigid:wc5o/SZJOkIQ0nBzqGt9wBo+JKE	false	calmodulin binding peptide plus protein a tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P62990	uniprotkb:P39109	intact:EBI-413053|uniprotkb:Q28170|uniprotkb:Q29120|uniprotkb:O97577|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:P80169|uniprotkb:Q01235|uniprotkb:Q24K23|uniprotkb:Q28169|uniprotkb:Q3ZCE3|uniprotkb:Q862C1|uniprotkb:Q862F4|uniprotkb:Q862M4|uniprotkb:Q862T5|uniprotkb:Q862X8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q3T0V5|dip:DIP-29049N	intact:EBI-21779|uniprotkb:Q03905|uniprotkb:D6VSB9|ensemblfungi:YDR135C	psi-mi:ubiq_bovin(display_long)|uniprotkb:RPS27A(gene name)|psi-mi:RPS27A(display_short)|uniprotkb:UBA80(gene name synonym)|uniprotkb:UBCEP1(gene name synonym)|uniprotkb:UBA52(gene name)|psi-mi:UBA52(display_short)|uniprotkb:UBCEP2(gene name synonym)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)|uniprotkb:UBC(gene name)|psi-mi:UBC(display_short)	psi-mi:ycfi_yeast(display_long)|uniprotkb:YCF1(gene name)|psi-mi:YCF1(display_short)|uniprotkb:YDR135C(locus name)|uniprotkb:YD9302.11C(orf name)|uniprotkb:Yeast cadmium factor 1(gene name synonym)|uniprotkb:"ABC-type Cd(2+) transporter"(gene name synonym)|uniprotkb:ABC-type glutathione-S-conjugate transporter(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakatsukasa et al. (2008)	imex:IM-11874|pubmed:18191224	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1637500|imex:IM-11874-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|refseq:NP_001069831.1|refseq:NP_777203.1|refseq:NP_776558.1|rcsb pdb:2QHO|rcsb pdb:2ZCC|ensembl:ENSBTAG00000015473|ensembl:ENSBTAG00000017246|rcsb pdb:1E0Q|rcsb pdb:2HD5|rcsb pdb:2OOB|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|rcsb pdb:3H1U|go:"GO:0005515"(protein binding)|go:"GO:0030528"(obsolete transcription regulator activity)|go:"GO:0045941"|go:"GO:0016567"(protein ubiquitination)|ensembl:ENSBTAG00000007737|rcsb pdb:1AAR|rcsb pdb:1P3Q|rcsb pdb:1UZX|rcsb pdb:1V80|rcsb pdb:1V81|rcsb pdb:1WR6|rcsb pdb:1WRD|rcsb pdb:1YD8|rcsb pdb:2C7M|rcsb pdb:2C7N|rcsb pdb:2D3G|rcsb pdb:2DX5|rcsb pdb:2FID|rcsb pdb:2FIF|go:"GO:0005634"(nucleus)|ipi:IPI00687665|rcsb pdb:2WWZ|rcsb pdb:2WX0|rcsb pdb:2WX1	sgd:S000002542|refseq:NP_010419.3|mint:P39109|dip:DIP-2612N|ensemblfungi:YDR135C(gene)|ensemblfungi:YDR135C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0008551"(P-type cadmium transporter activity)|go:"GO:0010038"(response to metal ion)|go:"GO:0015127"(bilirubin transmembrane transporter activity)|go:"GO:0015431"(ABC-type glutathione S-conjugate transporter activity)|go:"GO:0015434"(ABC-type cadmium transporter activity)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0015723"(bilirubin transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|rcsb pdb:7MPE|reactome:R-SCE-189483|reactome:R-SCE-196741|reactome:R-SCE-2142691|reactome:R-SCE-382556|reactome:R-SCE-9707564	go:"GO:0005792"(obsolete microsome)	-	-	delivery method:P39109 transfection|figure legend:Fig. Supp. S2|comment:Microsomes lacking Ubc6 and Ubc7 failed to support Ste6 ubiquitination. Microsomes lacking Doa10 or Hrd1 supported Ste6 ubiquitination, whereas  deletion of both these genes inhibited ubiquitination. Ssa1 and Ydj1/Hlj1 chaperones facilitate substrate ubiquitination|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/11	2014/10/16	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9913	rogid:8fsmjZtvwLEh9dMxvp/jkmo8zOA559292	intact-crc:C14192EDE0300A3C|rigid:5XMoo170tbRX2DOH0LzsOpI+Pxg	false	125i radiolabel:?-?	ha tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P62990	uniprotkb:P32915	intact:EBI-413053|uniprotkb:Q28170|uniprotkb:Q29120|uniprotkb:O97577|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:P80169|uniprotkb:Q01235|uniprotkb:Q24K23|uniprotkb:Q28169|uniprotkb:Q3ZCE3|uniprotkb:Q862C1|uniprotkb:Q862F4|uniprotkb:Q862M4|uniprotkb:Q862T5|uniprotkb:Q862X8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q3T0V5|dip:DIP-29049N	intact:EBI-16400|ensemblfungi:YLR378C|uniprotkb:D6VZ14	psi-mi:ubiq_bovin(display_long)|uniprotkb:RPS27A(gene name)|psi-mi:RPS27A(display_short)|uniprotkb:UBA80(gene name synonym)|uniprotkb:UBCEP1(gene name synonym)|uniprotkb:UBA52(gene name)|psi-mi:UBA52(display_short)|uniprotkb:UBCEP2(gene name synonym)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)|uniprotkb:UBC(gene name)|psi-mi:UBC(display_short)	psi-mi:sc61a_yeast(display_long)|uniprotkb:Sec61 complex subunit SEC61(gene name synonym)|uniprotkb:L3502.5(orf name)|uniprotkb:YLR378C(locus name)|uniprotkb:SEC61(gene name)|psi-mi:SEC61(display_short)|uniprotkb:Sec61 complex subunit alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakatsukasa et al. (2008)	imex:IM-11874|pubmed:18191224	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1637521|imex:IM-11874-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|refseq:NP_001069831.1|refseq:NP_777203.1|refseq:NP_776558.1|rcsb pdb:2QHO|rcsb pdb:2ZCC|ensembl:ENSBTAG00000015473|ensembl:ENSBTAG00000017246|rcsb pdb:1E0Q|rcsb pdb:2HD5|rcsb pdb:2OOB|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|rcsb pdb:3H1U|go:"GO:0005515"(protein binding)|go:"GO:0030528"(obsolete transcription regulator activity)|go:"GO:0045941"|go:"GO:0016567"(protein ubiquitination)|ensembl:ENSBTAG00000007737|rcsb pdb:1AAR|rcsb pdb:1P3Q|rcsb pdb:1UZX|rcsb pdb:1V80|rcsb pdb:1V81|rcsb pdb:1WR6|rcsb pdb:1WRD|rcsb pdb:1YD8|rcsb pdb:2C7M|rcsb pdb:2C7N|rcsb pdb:2D3G|rcsb pdb:2DX5|rcsb pdb:2FID|rcsb pdb:2FIF|go:"GO:0005634"(nucleus)|ipi:IPI00687665|rcsb pdb:2WWZ|rcsb pdb:2WX0|rcsb pdb:2WX1	go:"GO:0070843"(misfolded protein transport)|go:"GO:1904680"(peptide transmembrane transporter activity)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|rcsb pdb:6N3Q|rcsb pdb:6ND1|rcsb pdb:7AFT|rcsb pdb:7KAH|rcsb pdb:7KAI|rcsb pdb:7KAJ|rcsb pdb:7KAO|rcsb pdb:7KAP|rcsb pdb:7KAQ|rcsb pdb:7KAR|rcsb pdb:7KAS|rcsb pdb:7KAT|rcsb pdb:7KAU|rcsb pdb:7KB5|go:"GO:0044743"(protein transmembrane import into intracellular organelle)|ensemblfungi:YLR378C(gene)|ensemblfungi:YLR378C_mRNA(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0015450"(protein-transporting ATPase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0043022"(ribosome binding)|refseq:NP_013482.1|sgd:S000004370|dip:DIP-2433N|mint:P32915	go:"GO:0005792"(obsolete microsome)	-	-	delivery method:P32915 transfection|figure legend:Fig. Supp. S3|comment:Mutated protein Sec61-2 in which retrotranslocation across the ER membrane is prevented, shows increased ubiquitination over wild type|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/11	2014/10/16	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9913	rogid:Gi0aAi/lO9gi5h6LMgke4advNsM559292	intact-crc:F51A25180B19C5B8|rigid:xDecqu41uDn5NhH5tgd5xO2f1M4	false	125i radiolabel:?-?	ha tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P12866	uniprotkb:P40318	intact:EBI-18383|uniprotkb:D6VWZ4|ensemblfungi:YKL209C	intact:EBI-18208|uniprotkb:D6VVQ1|ensemblfungi:YIL030C	psi-mi:ste6_yeast(display_long)|uniprotkb:STE6(gene name)|psi-mi:STE6(display_short)|uniprotkb:Multiple drug resistance protein homolog(gene name synonym)|uniprotkb:P-glycoprotein(gene name synonym)|uniprotkb:Mating factor A secretion protein STE6(gene name synonym)|uniprotkb:YKL209C(locus name)	psi-mi:doa10_yeast(display_long)|uniprotkb:SSM4(gene name)|psi-mi:SSM4(display_short)|uniprotkb:DOA10(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DOA10(gene name synonym)|uniprotkb:YI3299.01C(orf name)|uniprotkb:YI9905.18C(orf name)|uniprotkb:YIL030C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakatsukasa et al. (2008)	imex:IM-11874|pubmed:18191224	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1637277|imex:IM-11874-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012713.1|sgd:S000001692|ensemblfungi:YKL209C(gene)|ensemblfungi:YKL209C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000770"(peptide pheromone export)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019236"(response to pheromone)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043332"(mating projection tip)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030246|interpro:IPR036640|reactome:R-SCE-382556|dip:DIP-2594N|mint:P12866	sgd:S000001292|ensemblfungi:YIL030C(gene)|ensemblfungi:YIL030C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:2M6M|refseq:NP_012234.3|dip:DIP-7286N|mint:P40318	go:"GO:0005792"(obsolete microsome)	crc64:B240B7E51D9680D5	crc64:3EDFF7F9D90A0C8C	delivery method:P12866; P40318 transfection|figure legend:Figs. 3B, 3D, 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/02/11	2014/10/16	rogid:G3ZhCo+dInWlxMbhtTagcCyAbXI559292	rogid:/rWhsEcXbPYVDvgXwErWb4rlhlE559292	intact-crc:4233D0BFC0E494E8|rigid:TrzANZWS0vzXWR5Mj6pb5w9OusU	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P12866	uniprotkb:P02829	intact:EBI-18383|uniprotkb:D6VWZ4|ensemblfungi:YKL209C	intact:EBI-8659|ensemblfungi:YPL240C|uniprotkb:D6W3D1	psi-mi:ste6_yeast(display_long)|uniprotkb:STE6(gene name)|psi-mi:STE6(display_short)|uniprotkb:Multiple drug resistance protein homolog(gene name synonym)|uniprotkb:P-glycoprotein(gene name synonym)|uniprotkb:Mating factor A secretion protein STE6(gene name synonym)|uniprotkb:YKL209C(locus name)	psi-mi:hsp82_yeast(display_long)|uniprotkb:HSP90(gene name synonym)|uniprotkb:YPL240C(locus name)|uniprotkb:HSP82(gene name)|psi-mi:HSP82(display_short)|uniprotkb:Heat shock protein Hsp90 heat-inducible isoform(gene name synonym)|uniprotkb:82 kDa heat shock protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakatsukasa et al. (2008)	imex:IM-11874|pubmed:18191224	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1637343|imex:IM-11874-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012713.1|sgd:S000001692|ensemblfungi:YKL209C(gene)|ensemblfungi:YKL209C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000770"(peptide pheromone export)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019236"(response to pheromone)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043332"(mating projection tip)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030246|interpro:IPR036640|reactome:R-SCE-382556|dip:DIP-2594N|mint:P12866	ensemblfungi:YPL240C(gene)|ensemblfungi:YPL240C_mRNA(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|rcsb pdb:1A4H|rcsb pdb:1AH6|rcsb pdb:1AH8|rcsb pdb:1AM1|rcsb pdb:1AMW|rcsb pdb:1BGQ|rcsb pdb:2WER|rcsb pdb:2XD6|rcsb pdb:2XX2|rcsb pdb:2XX4|rcsb pdb:2XX5|rcsb pdb:2YGA|rcsb pdb:2YGE|rcsb pdb:2YGF|rcsb pdb:3C0E|rcsb pdb:3C11|rcsb pdb:3FP2|rcsb pdb:4AS9|rcsb pdb:4ASA|rcsb pdb:4ASB|rcsb pdb:4ASF|rcsb pdb:2IWU|rcsb pdb:2IWX|rcsb pdb:2LSV|rcsb pdb:2VW5|rcsb pdb:2VWC|rcsb pdb:2WEP|rcsb pdb:4ASG|rcsb pdb:4CE1|rcsb pdb:4CE2|rcsb pdb:4CE3|rcsb pdb:5MGX|reactome:R-SCE-1474151|rcsb pdb:2WEQ|reactome:R-SCE-203615|reactome:R-SCE-3371497|reactome:R-SCE-3371511|reactome:R-SCE-3371571|reactome:R-SCE-5218920|reactome:R-SCE-6798695|reactome:R-SCE-844456|reactome:R-SCE-9009391|rcsb pdb:1HK7|rcsb pdb:1US7|rcsb pdb:1USU|rcsb pdb:1USV|rcsb pdb:1ZW9|rcsb pdb:1ZWH|rcsb pdb:2AKP|rcsb pdb:2BRC|rcsb pdb:2BRE|rcsb pdb:2CG9|rcsb pdb:2CGE|rcsb pdb:2CGF|rcsb pdb:2FXS|rcsb pdb:2IWS|refseq:NP_015084.1|sgd:S000006161|mint:P02829|dip:DIP-2262N	psi-mi:"MI:0469"(intact)	crc64:B240B7E51D9680D5	crc64:D7C35676D668FB63	delivery method:P12866; P40318 transfection|figure legend:Figs. 4E|comment:A fraction of Hsp82p was also precipitated under denaturing conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/02/11	2014/10/16	rogid:G3ZhCo+dInWlxMbhtTagcCyAbXI559292	rogid:K7/2Z6pLnYGlRxPVLyePuy/ECrk559292	intact-crc:65AAF0E7080BEB84|rigid:APJKw948L1S0buFqCYf0fY4YK1E	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P12866	uniprotkb:P40318	intact:EBI-18383|uniprotkb:D6VWZ4|ensemblfungi:YKL209C	intact:EBI-18208|uniprotkb:D6VVQ1|ensemblfungi:YIL030C	psi-mi:ste6_yeast(display_long)|uniprotkb:STE6(gene name)|psi-mi:STE6(display_short)|uniprotkb:Multiple drug resistance protein homolog(gene name synonym)|uniprotkb:P-glycoprotein(gene name synonym)|uniprotkb:Mating factor A secretion protein STE6(gene name synonym)|uniprotkb:YKL209C(locus name)	psi-mi:doa10_yeast(display_long)|uniprotkb:SSM4(gene name)|psi-mi:SSM4(display_short)|uniprotkb:DOA10(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DOA10(gene name synonym)|uniprotkb:YI3299.01C(orf name)|uniprotkb:YI9905.18C(orf name)|uniprotkb:YIL030C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakatsukasa et al. (2008)	imex:IM-11874|pubmed:18191224	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1637343|imex:IM-11874-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012713.1|sgd:S000001692|ensemblfungi:YKL209C(gene)|ensemblfungi:YKL209C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000770"(peptide pheromone export)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019236"(response to pheromone)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043332"(mating projection tip)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030246|interpro:IPR036640|reactome:R-SCE-382556|dip:DIP-2594N|mint:P12866	sgd:S000001292|ensemblfungi:YIL030C(gene)|ensemblfungi:YIL030C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:2M6M|refseq:NP_012234.3|dip:DIP-7286N|mint:P40318	psi-mi:"MI:0469"(intact)	crc64:B240B7E51D9680D5	crc64:3EDFF7F9D90A0C8C	delivery method:P12866; P40318 transfection|figure legend:Figs. 4E|comment:A fraction of Hsp82p was also precipitated under denaturing conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/02/11	2014/10/16	rogid:G3ZhCo+dInWlxMbhtTagcCyAbXI559292	rogid:/rWhsEcXbPYVDvgXwErWb4rlhlE559292	intact-crc:65AAF0E7080BEB84|rigid:APJKw948L1S0buFqCYf0fY4YK1E	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P12866	uniprotkb:P10591	intact:EBI-18383|uniprotkb:D6VWZ4|ensemblfungi:YKL209C	intact:EBI-8591|uniprotkb:D6VPL2|ensemblfungi:YAL005C	psi-mi:ste6_yeast(display_long)|uniprotkb:STE6(gene name)|psi-mi:STE6(display_short)|uniprotkb:Multiple drug resistance protein homolog(gene name synonym)|uniprotkb:P-glycoprotein(gene name synonym)|uniprotkb:Mating factor A secretion protein STE6(gene name synonym)|uniprotkb:YKL209C(locus name)	psi-mi:hsp71_yeast(display_long)|uniprotkb:YAL005C(locus name)|uniprotkb:SSA1(gene name)|psi-mi:SSA1(display_short)|uniprotkb:Heat shock protein YG100(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakatsukasa et al. (2008)	imex:IM-11874|pubmed:18191224	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1637343|imex:IM-11874-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012713.1|sgd:S000001692|ensemblfungi:YKL209C(gene)|ensemblfungi:YKL209C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000770"(peptide pheromone export)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019236"(response to pheromone)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043332"(mating projection tip)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030246|interpro:IPR036640|reactome:R-SCE-382556|dip:DIP-2594N|mint:P12866	refseq:NP_009396.2|sgd:S000000004|mint:P10591|dip:DIP-2253N|ensemblfungi:YAL005C(gene)|ensemblfungi:YAL005C_mRNA(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0009277"(fungal-type cell wall)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0042026"(protein refolding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0090344"(negative regulation of cell aging)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:3LCA|rcsb pdb:5LYN|rcsb pdb:5Z8I|rcsb pdb:5Z8Q	psi-mi:"MI:0469"(intact)	crc64:B240B7E51D9680D5	crc64:249D8A3BC42527CA	delivery method:P12866; P40318 transfection|figure legend:Figs. 4E|comment:A fraction of Hsp82p was also precipitated under denaturing conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/02/11	2014/10/16	rogid:G3ZhCo+dInWlxMbhtTagcCyAbXI559292	rogid:3GvAKzWWSou3MW9HqZVxC+Wkkqk559292	intact-crc:65AAF0E7080BEB84|rigid:APJKw948L1S0buFqCYf0fY4YK1E	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P12866	uniprotkb:P25491	intact:EBI-18383|uniprotkb:D6VWZ4|ensemblfungi:YKL209C	intact:EBI-10420|ensemblfungi:YNL064C|uniprotkb:D6W1B6	psi-mi:ste6_yeast(display_long)|uniprotkb:STE6(gene name)|psi-mi:STE6(display_short)|uniprotkb:Multiple drug resistance protein homolog(gene name synonym)|uniprotkb:P-glycoprotein(gene name synonym)|uniprotkb:Mating factor A secretion protein STE6(gene name synonym)|uniprotkb:YKL209C(locus name)	psi-mi:mas5_yeast(display_long)|uniprotkb:YDJ1(gene name)|psi-mi:YDJ1(display_short)|uniprotkb:MAS5(gene name synonym)|uniprotkb:YNL064C(locus name)|uniprotkb:N2418(orf name)|uniprotkb:YNL2418C(orf name)|uniprotkb:Yeast dnaJ protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakatsukasa et al. (2008)	imex:IM-11874|pubmed:18191224	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1637343|imex:IM-11874-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012713.1|sgd:S000001692|ensemblfungi:YKL209C(gene)|ensemblfungi:YKL209C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000770"(peptide pheromone export)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019236"(response to pheromone)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043332"(mating projection tip)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030246|interpro:IPR036640|reactome:R-SCE-382556|dip:DIP-2594N|mint:P12866	refseq:NP_014335.1|sgd:S000005008|ensemblfungi:YNL064C_mRNA(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006458"('de novo' protein folding)|ensemblfungi:YNL064C(gene)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0009408"(response to heat)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0035719"(tRNA import into nucleus)|go:"GO:0042026"(protein refolding)|go:"GO:0045047"(protein targeting to ER)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0072380"(TRC complex)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|rcsb pdb:1NLT|rcsb pdb:1XAO|rcsb pdb:5VSO|reactome:R-SCE-3371497|interpro:IPR018253|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|dip:DIP-2251N|mint:P25491	psi-mi:"MI:0469"(intact)	crc64:B240B7E51D9680D5	crc64:E4539F3618DD9CF2	delivery method:P12866; P40318 transfection|figure legend:Figs. 4E|comment:A fraction of Hsp82p was also precipitated under denaturing conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/02/11	2014/10/16	rogid:G3ZhCo+dInWlxMbhtTagcCyAbXI559292	rogid:oFw3ARy6McOdWBXpq0WK6si5GYw559292	intact-crc:65AAF0E7080BEB84|rigid:APJKw948L1S0buFqCYf0fY4YK1E	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-19797	uniprotkb:P12866	dip:DIP-1549N|uniprotkb:P04838|uniprotkb:Q6LA96	intact:EBI-18383|uniprotkb:D6VWZ4|ensemblfungi:YKL209C	psi-mi:ubiq_yeast(display_short)|psi-mi:EBI-19797(display_long)|uniprotkb:UBI1(gene name)|psi-mi:UBI1(display_short)|uniprotkb:RPL40A(gene name synonym)|uniprotkb:YIL148W(locus name)|uniprotkb:UBI2(gene name)|psi-mi:UBI2(display_short)|uniprotkb:RPL40B(gene name synonym)|uniprotkb:YKR094C(locus name)|uniprotkb:UBI3(gene name)|psi-mi:UBI3(display_short)|uniprotkb:RPS31(gene name synonym)|uniprotkb:YLR167W(locus name)|uniprotkb:L9470.14(orf name)|uniprotkb:UBI4(gene name)|psi-mi:UBI4(display_short)|uniprotkb:SCD2(gene name synonym)|uniprotkb:YLL039C(locus name)	psi-mi:ste6_yeast(display_long)|uniprotkb:STE6(gene name)|psi-mi:STE6(display_short)|uniprotkb:Multiple drug resistance protein homolog(gene name synonym)|uniprotkb:P-glycoprotein(gene name synonym)|uniprotkb:Mating factor A secretion protein STE6(gene name synonym)|uniprotkb:YKL209C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakatsukasa et al. (2008)	imex:IM-11874|pubmed:18191224	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1637385|imex:IM-11874-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001410(RPL40A)|sgd:S000001802(RPL40B)|sgd:S000004157(RPS31)|sgd:S000003962(UBI4)|uniprotkb:P61864(see-also)|refseq:NP_012118.1|refseq:NP_013020.1|refseq:NP_013061.1|refseq:NP_013268.1|ensembl:YIL148W|ensembl:YKR094C|ensembl:YLR167W|go:"GO:0005515"(protein binding)|interpro:IPR000626(Ubiquitin)|cygd:YLR167w|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0005739"(mitochondrion)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0006412"(translation)|ensembl:YLL039C|rcsb pdb:1OTR|rcsb pdb:1Q0W|rcsb pdb:1WR1|rcsb pdb:1ZW7|rcsb pdb:2G3Q|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|cygd:YIL148w|cygd:YKR094c|cygd:YLL039c|rcsb pdb:2JT4|rcsb pdb:2JWZ|rcsb pdb:3CMM|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|rcsb pdb:3L0W|rcsb pdb:3L10|rcsb pdb:3MHS|rcsb pdb:2KDI	refseq:NP_012713.1|sgd:S000001692|ensemblfungi:YKL209C(gene)|ensemblfungi:YKL209C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000770"(peptide pheromone export)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019236"(response to pheromone)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043332"(mating projection tip)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030246|interpro:IPR036640|reactome:R-SCE-382556|dip:DIP-2594N|mint:P12866	go:"GO:0005792"(obsolete microsome)	no-uniprot-update:obsolete protein	crc64:B240B7E51D9680D5	delivery method:P12866; P61864 transfection|figure legend:Figs. 2D, 5D and Supp. Fig. 4B|comment:Ufd2 is required for ubiquitin elongation - in its absence ubiqutinated Ste6 was of a lower molecular weight. Ste6p ubiquitination is Ssap-1 dependent.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/11	2014/10/16	rogid:sUFDb7kGedoC/k80bI4sjOaMLHs4932	rogid:G3ZhCo+dInWlxMbhtTagcCyAbXI559292	intact-crc:A83CC12E09FF2068|rigid:0NLcHAbj01eeAyMGbFR8i1O0I8g	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)