#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P34971	uniprotkb:Q01063	intact:EBI-7764182|ensembl:ENSMUSP00000040847|uniprotkb:B2RVY4|intact:UNK-5376537	intact:EBI-7764239|ensembl:ENSMUSP00000113488|ensembl:ENSMUSP00000136485|uniprotkb:Q8CG05|uniprotkb:Q8C4Q7|intact:UNK-5385073|uniprotkb:B2KF58|uniprotkb:Q6TRH9	psi-mi:adrb1_mouse(display_long)|uniprotkb:Adrb1(gene name)|psi-mi:Adrb1(display_short)|uniprotkb:Adrb1r(gene name synonym)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)	psi-mi:pde4d_mouse(display_long)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Richter et al. (2008)	pubmed:18188154|imex:IM-11524|mint:MINT-6179515	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7764176|mint:MINT-6179523|imex:IM-11524-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000035283(gene)|ensembl:ENSMUST00000038949(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0003061"(positive regulation of the force of heart contraction by norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007613"(memory)|go:"GO:0009409"(response to cold)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042596"(fear response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P34971|reactome:R-MMU-390696|reactome:R-MMU-418555|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|refseq:NP_031445.2|dip:DIP-59567N|mint:MINT-6179526(identity)	ensembl:ENSMUSG00000021699(gene)|ensembl:ENSMUST00000122041(transcript)|ensembl:ENSMUST00000177907(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006198"(cAMP catabolic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007568"(aging)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034704"(calcium channel complex)|go:"GO:0034705"(potassium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1901898"(negative regulation of relaxation of cardiac muscle)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR036971|interpro:IPR040844|mint:Q01063|reactome:R-MMU-180024|reactome:R-MMU-418555|go:"GO:0050900"(leukocyte migration)|refseq:NP_035186.1|refseq:XP_006517710.1|dip:DIP-29706N|mint:MINT-6179525(identity)	-	caution:This sequence has been withdrawn from Uniprot.|function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity|comment:mint	comment:mint|function:Regulates the levels of cAMP in the cell	figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cardiac myocyt)|taxid:10090(Mus musculus)	-	2008/02/14	2014/10/16	rogid:dj37utBcHAaPRbEypLNUA/CgH5k10090	rogid:AccySsTfwmeaWakWyiGRFhqJ+4Y10090	intact-crc:F94AC54C51B19087|rigid:ImA/eEF+pYr30nVsX1k23/IoCCk	false	flag tag:?-?(MINT-6179528)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P34971	uniprotkb:P05132	intact:EBI-7764182|ensembl:ENSMUSP00000040847|uniprotkb:B2RVY4|intact:UNK-5376537	intact:EBI-400564|uniprotkb:Q9JID0|ensembl:ENSMUSP00000005606	psi-mi:adrb1_mouse(display_long)|uniprotkb:Adrb1(gene name)|psi-mi:Adrb1(display_short)|uniprotkb:Adrb1r(gene name synonym)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)	psi-mi:kapca_mouse(display_long)|uniprotkb:Prkaca(gene name)|psi-mi:Prkaca(display_short)|uniprotkb:Pkaca(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Richter et al. (2008)	pubmed:18188154|imex:IM-11524|mint:MINT-6179515	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7764319|mint:MINT-6179569|imex:IM-11524-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000035283(gene)|ensembl:ENSMUST00000038949(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0003061"(positive regulation of the force of heart contraction by norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007613"(memory)|go:"GO:0009409"(response to cold)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042596"(fear response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P34971|reactome:R-MMU-390696|reactome:R-MMU-418555|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|refseq:NP_031445.2|dip:DIP-59567N|mint:MINT-6179571(identity)	refseq:NP_001264827.1|refseq:NP_032880.1|reactome:R-MMU-8963896|reactome:R-MMU-983231|ensembl:ENSMUSG00000005469(gene)|go:"GO:0097546"(ciliary base)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044109|mint:P05132|ensembl:ENSMUST00000005606(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048792"(spontaneous exocytosis of neurotransmitter)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0097225"(sperm midpiece)|rcsb pdb:1APM|rcsb pdb:1ATP|rcsb pdb:1BKX|rcsb pdb:1BX6|rcsb pdb:1FMO|rcsb pdb:1J3H|rcsb pdb:1JBP|rcsb pdb:1JLU|rcsb pdb:1L3R|rcsb pdb:1PVK|rcsb pdb:1RDQ|rcsb pdb:1RE8|rcsb pdb:1REJ|rcsb pdb:1REK|rcsb pdb:1SYK|rcsb pdb:2CPK|rcsb pdb:2ERZ|rcsb pdb:2QCS|rcsb pdb:2QUR|rcsb pdb:2QVS|rcsb pdb:3FHI|rcsb pdb:3FJQ|rcsb pdb:3IDB|rcsb pdb:3IDC|rcsb pdb:3J4Q|rcsb pdb:3J4R|rcsb pdb:3O7L|rcsb pdb:3OW3|rcsb pdb:3PVB|rcsb pdb:3QAL|rcsb pdb:3QAM|rcsb pdb:3TNP|rcsb pdb:3TNQ|rcsb pdb:3X2U|rcsb pdb:3X2V|rcsb pdb:3X2W|rcsb pdb:4DFX|rcsb pdb:4DFY|rcsb pdb:4DFZ|rcsb pdb:4DG0|rcsb pdb:4DG2|rcsb pdb:4DG3|rcsb pdb:4DH1|rcsb pdb:4DH3|rcsb pdb:4DH5|rcsb pdb:4DH7|rcsb pdb:4DH8|rcsb pdb:4DIN|rcsb pdb:4HPT|rcsb pdb:4HPU|rcsb pdb:4IAC|rcsb pdb:4IAD|rcsb pdb:4IAF|rcsb pdb:4IAI|rcsb pdb:4IAK|rcsb pdb:4IAY|rcsb pdb:4IAZ|rcsb pdb:4IB0|rcsb pdb:4IB1|rcsb pdb:4IB3|rcsb pdb:4NTS|rcsb pdb:4NTT|rcsb pdb:4O21|rcsb pdb:4O22|rcsb pdb:4WBB|rcsb pdb:4X6Q|rcsb pdb:4X6R|rcsb pdb:4XW4|rcsb pdb:4XW5|rcsb pdb:4XW6|rcsb pdb:5JR7|rcsb pdb:5X3F|rcsb pdb:6E21|rcsb pdb:6MM5|rcsb pdb:6MM6|rcsb pdb:6MM7|rcsb pdb:6MM8|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-422356|reactome:R-MMU-432040|reactome:R-MMU-4420097|reactome:R-MMU-442720|reactome:R-MMU-512988|reactome:R-MMU-5578775|reactome:R-MMU-5610785|reactome:R-MMU-5610787|reactome:R-MMU-5620912|reactome:R-MMU-5621575|reactome:R-MMU-5687128|reactome:R-MMU-8853659|reactome:R-MMU-8854518|dip:DIP-6086N|mint:MINT-6179575(identity)	-	caution:This sequence has been withdrawn from Uniprot.|function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity|comment:mint	-	figure legend:f6e f6c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cardiac myocyt)|taxid:10090(Mus musculus)	-	2008/02/14	2014/10/16	rogid:dj37utBcHAaPRbEypLNUA/CgH5k10090	rogid:HdW51RuiujpUxo0Fu8TbWz3Yk8c10090	intact-crc:9FF7E8755DAFD9CF|rigid:4VCjlgGNZMt/OSbBPN0UkqRYd1E	false	flag tag:?-?(MINT-6179572)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P34971	uniprotkb:Q01063	intact:EBI-7764182|ensembl:ENSMUSP00000040847|uniprotkb:B2RVY4|intact:UNK-5376537	intact:EBI-7764239|ensembl:ENSMUSP00000113488|ensembl:ENSMUSP00000136485|uniprotkb:Q8CG05|uniprotkb:Q8C4Q7|intact:UNK-5385073|uniprotkb:B2KF58|uniprotkb:Q6TRH9	psi-mi:adrb1_mouse(display_long)|uniprotkb:Adrb1(gene name)|psi-mi:Adrb1(display_short)|uniprotkb:Adrb1r(gene name synonym)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)	psi-mi:pde4d_mouse(display_long)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Richter et al. (2008)	pubmed:18188154|imex:IM-11524|mint:MINT-6179515	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7764573|mint:MINT-6179539|imex:IM-11524-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000035283(gene)|ensembl:ENSMUST00000038949(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0003061"(positive regulation of the force of heart contraction by norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007613"(memory)|go:"GO:0009409"(response to cold)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042596"(fear response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P34971|reactome:R-MMU-390696|reactome:R-MMU-418555|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|refseq:NP_031445.2|dip:DIP-59567N|mint:MINT-6179543(identity)	ensembl:ENSMUSG00000021699(gene)|ensembl:ENSMUST00000122041(transcript)|ensembl:ENSMUST00000177907(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006198"(cAMP catabolic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007568"(aging)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034704"(calcium channel complex)|go:"GO:0034705"(potassium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1901898"(negative regulation of relaxation of cardiac muscle)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR036971|interpro:IPR040844|mint:Q01063|reactome:R-MMU-180024|reactome:R-MMU-418555|go:"GO:0050900"(leukocyte migration)|refseq:NP_035186.1|refseq:XP_006517710.1|dip:DIP-29706N|mint:MINT-6179541(identity)	-	caution:This sequence has been withdrawn from Uniprot.|function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity|comment:mint	comment:mint|function:Regulates the levels of cAMP in the cell	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/02/14	2014/10/16	rogid:dj37utBcHAaPRbEypLNUA/CgH5k10090	rogid:AccySsTfwmeaWakWyiGRFhqJ+4Y10090	intact-crc:386D423CB05EC059|rigid:ImA/eEF+pYr30nVsX1k23/IoCCk	false	flag tag:?-?(MINT-6179544)	myc tag:?-?(MINT-6179549)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q01063	uniprotkb:P34971	intact:EBI-7764239|ensembl:ENSMUSP00000113488|ensembl:ENSMUSP00000136485|uniprotkb:Q8CG05|uniprotkb:Q8C4Q7|intact:UNK-5385073|uniprotkb:B2KF58|uniprotkb:Q6TRH9	intact:EBI-7764182|ensembl:ENSMUSP00000040847|uniprotkb:B2RVY4|intact:UNK-5376537	psi-mi:pde4d_mouse(display_long)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym)	psi-mi:adrb1_mouse(display_long)|uniprotkb:Adrb1(gene name)|psi-mi:Adrb1(display_short)|uniprotkb:Adrb1r(gene name synonym)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Richter et al. (2008)	pubmed:18188154|imex:IM-11524|mint:MINT-6179515	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7764617|mint:MINT-6179556|imex:IM-11524-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021699(gene)|ensembl:ENSMUST00000122041(transcript)|ensembl:ENSMUST00000177907(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006198"(cAMP catabolic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007568"(aging)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034704"(calcium channel complex)|go:"GO:0034705"(potassium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1901898"(negative regulation of relaxation of cardiac muscle)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR036971|interpro:IPR040844|mint:Q01063|reactome:R-MMU-180024|reactome:R-MMU-418555|go:"GO:0050900"(leukocyte migration)|refseq:NP_035186.1|refseq:XP_006517710.1|dip:DIP-29706N|mint:MINT-6179562(identity)	ensembl:ENSMUSG00000035283(gene)|ensembl:ENSMUST00000038949(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0003061"(positive regulation of the force of heart contraction by norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007613"(memory)|go:"GO:0009409"(response to cold)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042596"(fear response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P34971|reactome:R-MMU-390696|reactome:R-MMU-418555|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|refseq:NP_031445.2|dip:DIP-59567N|mint:MINT-6179558(identity)	-	comment:mint|function:Regulates the levels of cAMP in the cell	caution:This sequence has been withdrawn from Uniprot.|function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity|comment:mint	figure legend:f3d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/14	2014/10/16	rogid:AccySsTfwmeaWakWyiGRFhqJ+4Y10090	rogid:dj37utBcHAaPRbEypLNUA/CgH5k10090	intact-crc:B9620FAF7F4F0686|rigid:ImA/eEF+pYr30nVsX1k23/IoCCk	false	-	flag tag:?-?(MINT-6179559)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)