#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96P48	uniprotkb:O00220	intact:EBI-710003|uniprotkb:O94879|uniprotkb:Q4LDD5|uniprotkb:Q59FI7|uniprotkb:Q6PHS3|uniprotkb:Q8WU51|uniprotkb:Q96HP6|uniprotkb:A3KLL7|uniprotkb:Q96L71|uniprotkb:B2RTS2|intact:EBI-28975539|ensembl:ENSP00000377233	intact:EBI-518861|uniprotkb:Q96E62|ensembl:ENSP00000221132|uniprotkb:A8K5I4|uniprotkb:Q53Y72	psi-mi:arap1_human(display_long)|uniprotkb:ARAP1(gene name)|psi-mi:ARAP1(display_short)|uniprotkb:CENTD2(gene name synonym)|uniprotkb:Centaurin-delta-2(gene name synonym)|uniprotkb:KIAA0782(gene name synonym)	psi-mi:tr10a_human(display_long)|uniprotkb:Death receptor 4(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 1(gene name synonym)|uniprotkb:TNFRSF10A(gene name)|psi-mi:TNFRSF10A(display_short)|uniprotkb:APO2(gene name synonym)|uniprotkb:DR4(gene name synonym)|uniprotkb:TRAILR1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Simova et al. (2007)	pubmed:18165900|imex:IM-19798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1581234|imex:IM-19798-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035207.1|refseq:NP_001128662.1|refseq:NP_056057.2|ensembl:ENSP00000403127|ensembl:ENST00000334211|ensembl:ENSP00000335506|ensembl:ENST00000359373|ensembl:ENSP00000352332|ensembl:ENST00000393605|ensembl:ENSP00000377230|ensembl:ENSP00000377233|ensembl:ENST00000429686|ensembl:ENSG00000186635(gene)|ensembl:ENST00000393609(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030037"(actin filament reorganization involved in cell cycle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051270"(regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|interpro:IPR000159(Ras-association)|interpro:IPR000198(RhoGAP)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037278|interpro:IPR037858|interpro:IPR038508|rcsb pdb:4X1V|reactome:R-HSA-8849469|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149	interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|mint:O00220|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENSG00000104689(gene)|ensembl:ENST00000221132(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005035"(death receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045569"(TRAIL binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|refseq:NP_003835.3	-	-	-	figure legend:1 A|caution:The CENTD2 protein is an isoform lacking 11 amino acids near to the C-terminus but this could not be unambiguously mapped to a single UniprotKB isoform|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/01/17	2014/10/16	rogid:AI7JgE3FapPBfnzcwT+AtENUXbg9606	rogid:utFDDi1uRCNlMUCt29SYzzar6Sc9606	intact-crc:BA69B67DCDA61B3B|rigid:0LRBMxnQkxhQEf/r6vUGzAoVFIQ	false	sufficient binding region:1190-1450	sufficient binding region:269-468	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96P48	uniprotkb:O00220	intact:EBI-710003|uniprotkb:O94879|uniprotkb:Q4LDD5|uniprotkb:Q59FI7|uniprotkb:Q6PHS3|uniprotkb:Q8WU51|uniprotkb:Q96HP6|uniprotkb:A3KLL7|uniprotkb:Q96L71|uniprotkb:B2RTS2|intact:EBI-28975539|ensembl:ENSP00000377233	intact:EBI-518861|uniprotkb:Q96E62|ensembl:ENSP00000221132|uniprotkb:A8K5I4|uniprotkb:Q53Y72	psi-mi:arap1_human(display_long)|uniprotkb:ARAP1(gene name)|psi-mi:ARAP1(display_short)|uniprotkb:CENTD2(gene name synonym)|uniprotkb:Centaurin-delta-2(gene name synonym)|uniprotkb:KIAA0782(gene name synonym)	psi-mi:tr10a_human(display_long)|uniprotkb:Death receptor 4(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 1(gene name synonym)|uniprotkb:TNFRSF10A(gene name)|psi-mi:TNFRSF10A(display_short)|uniprotkb:APO2(gene name synonym)|uniprotkb:DR4(gene name synonym)|uniprotkb:TRAILR1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Simova et al. (2007)	pubmed:18165900|imex:IM-19798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1581253|imex:IM-19798-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035207.1|refseq:NP_001128662.1|refseq:NP_056057.2|ensembl:ENSP00000403127|ensembl:ENST00000334211|ensembl:ENSP00000335506|ensembl:ENST00000359373|ensembl:ENSP00000352332|ensembl:ENST00000393605|ensembl:ENSP00000377230|ensembl:ENSP00000377233|ensembl:ENST00000429686|ensembl:ENSG00000186635(gene)|ensembl:ENST00000393609(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030037"(actin filament reorganization involved in cell cycle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051270"(regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|interpro:IPR000159(Ras-association)|interpro:IPR000198(RhoGAP)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037278|interpro:IPR037858|interpro:IPR038508|rcsb pdb:4X1V|reactome:R-HSA-8849469|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149	interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|mint:O00220|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENSG00000104689(gene)|ensembl:ENST00000221132(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005035"(death receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045569"(TRAIL binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|refseq:NP_003835.3	-	-	-	figure legend:1 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/01/17	2014/10/16	rogid:AI7JgE3FapPBfnzcwT+AtENUXbg9606	rogid:utFDDi1uRCNlMUCt29SYzzar6Sc9606	intact-crc:698930A39EA091C6|rigid:0LRBMxnQkxhQEf/r6vUGzAoVFIQ	false	sufficient binding region:1190-1450	sufficient binding region:269-468	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96P48	uniprotkb:O00220	intact:EBI-710003|uniprotkb:O94879|uniprotkb:Q4LDD5|uniprotkb:Q59FI7|uniprotkb:Q6PHS3|uniprotkb:Q8WU51|uniprotkb:Q96HP6|uniprotkb:A3KLL7|uniprotkb:Q96L71|uniprotkb:B2RTS2|intact:EBI-28975539|ensembl:ENSP00000377233	intact:EBI-518861|uniprotkb:Q96E62|ensembl:ENSP00000221132|uniprotkb:A8K5I4|uniprotkb:Q53Y72	psi-mi:arap1_human(display_long)|uniprotkb:ARAP1(gene name)|psi-mi:ARAP1(display_short)|uniprotkb:CENTD2(gene name synonym)|uniprotkb:Centaurin-delta-2(gene name synonym)|uniprotkb:KIAA0782(gene name synonym)	psi-mi:tr10a_human(display_long)|uniprotkb:Death receptor 4(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 1(gene name synonym)|uniprotkb:TNFRSF10A(gene name)|psi-mi:TNFRSF10A(display_short)|uniprotkb:APO2(gene name synonym)|uniprotkb:DR4(gene name synonym)|uniprotkb:TRAILR1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Simova et al. (2007)	pubmed:18165900|imex:IM-19798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1581280|imex:IM-19798-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035207.1|refseq:NP_001128662.1|refseq:NP_056057.2|ensembl:ENSP00000403127|ensembl:ENST00000334211|ensembl:ENSP00000335506|ensembl:ENST00000359373|ensembl:ENSP00000352332|ensembl:ENST00000393605|ensembl:ENSP00000377230|ensembl:ENSP00000377233|ensembl:ENST00000429686|ensembl:ENSG00000186635(gene)|ensembl:ENST00000393609(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030037"(actin filament reorganization involved in cell cycle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051270"(regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|interpro:IPR000159(Ras-association)|interpro:IPR000198(RhoGAP)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037278|interpro:IPR037858|interpro:IPR038508|rcsb pdb:4X1V|reactome:R-HSA-8849469|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149	interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|mint:O00220|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENSG00000104689(gene)|ensembl:ENST00000221132(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005035"(death receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045569"(TRAIL binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|refseq:NP_003835.3	-	-	-	figure legend:2 A, B|comment:Full-length ARAP1 Delta exon 30 co-immunoprecipitated with DR4, but less efficiently than its C-terminal part.|comment:"In the DR4 death domain, phe368 asp369 are conserved when compared to DR5. Their substitution with the corresponding amino acids from TNFR1 (proline and leucine) in mutant DR4-FD/PL led to the severe suppression of ARAP1-CDexon30 co-immunoprecipitation with DR4."|delivery method:O00220; Q96P48-3 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/01/17	2014/10/16	rogid:AI7JgE3FapPBfnzcwT+AtENUXbg9606	rogid:utFDDi1uRCNlMUCt29SYzzar6Sc9606	intact-crc:F1FBFB1980C6F6F2|rigid:0LRBMxnQkxhQEf/r6vUGzAoVFIQ	false	sufficient binding region:1190-1450|myc tag:?-?	necessary binding region:365-378|mutation decreasing interaction:368-368,369-369	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96P48	uniprotkb:O14763	intact:EBI-710003|uniprotkb:O94879|uniprotkb:Q4LDD5|uniprotkb:Q59FI7|uniprotkb:Q6PHS3|uniprotkb:Q8WU51|uniprotkb:Q96HP6|uniprotkb:A3KLL7|uniprotkb:Q96L71|uniprotkb:B2RTS2|intact:EBI-28975539|ensembl:ENSP00000377233	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:arap1_human(display_long)|uniprotkb:ARAP1(gene name)|psi-mi:ARAP1(display_short)|uniprotkb:CENTD2(gene name synonym)|uniprotkb:Centaurin-delta-2(gene name synonym)|uniprotkb:KIAA0782(gene name synonym)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Simova et al. (2007)	pubmed:18165900|imex:IM-19798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1581300|imex:IM-19798-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035207.1|refseq:NP_001128662.1|refseq:NP_056057.2|ensembl:ENSP00000403127|ensembl:ENST00000334211|ensembl:ENSP00000335506|ensembl:ENST00000359373|ensembl:ENSP00000352332|ensembl:ENST00000393605|ensembl:ENSP00000377230|ensembl:ENSP00000377233|ensembl:ENST00000429686|ensembl:ENSG00000186635(gene)|ensembl:ENST00000393609(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030037"(actin filament reorganization involved in cell cycle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051270"(regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|interpro:IPR000159(Ras-association)|interpro:IPR000198(RhoGAP)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037278|interpro:IPR037858|interpro:IPR038508|rcsb pdb:4X1V|reactome:R-HSA-8849469|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	-	-	figure legend:2 B|comment:Myc-tagged ARAP1-CDexon30 co-immunoprecipitated with DR5 but to a lesser extent than with DR4.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/01/17	2014/10/16	rogid:AI7JgE3FapPBfnzcwT+AtENUXbg9606	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:432948057FE4D910|rigid:REzgj+1KVTJeFLGAfy213BcszhM	false	myc tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96P48	uniprotkb:O00220	intact:EBI-710003|uniprotkb:O94879|uniprotkb:Q4LDD5|uniprotkb:Q59FI7|uniprotkb:Q6PHS3|uniprotkb:Q8WU51|uniprotkb:Q96HP6|uniprotkb:A3KLL7|uniprotkb:Q96L71|uniprotkb:B2RTS2|intact:EBI-28975539|ensembl:ENSP00000377233	intact:EBI-518861|uniprotkb:Q96E62|ensembl:ENSP00000221132|uniprotkb:A8K5I4|uniprotkb:Q53Y72	psi-mi:arap1_human(display_long)|uniprotkb:ARAP1(gene name)|psi-mi:ARAP1(display_short)|uniprotkb:CENTD2(gene name synonym)|uniprotkb:Centaurin-delta-2(gene name synonym)|uniprotkb:KIAA0782(gene name synonym)	psi-mi:tr10a_human(display_long)|uniprotkb:Death receptor 4(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 1(gene name synonym)|uniprotkb:TNFRSF10A(gene name)|psi-mi:TNFRSF10A(display_short)|uniprotkb:APO2(gene name synonym)|uniprotkb:DR4(gene name synonym)|uniprotkb:TRAILR1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Simova et al. (2007)	pubmed:18165900|imex:IM-19798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1581318|imex:IM-19798-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035207.1|refseq:NP_001128662.1|refseq:NP_056057.2|ensembl:ENSP00000403127|ensembl:ENST00000334211|ensembl:ENSP00000335506|ensembl:ENST00000359373|ensembl:ENSP00000352332|ensembl:ENST00000393605|ensembl:ENSP00000377230|ensembl:ENSP00000377233|ensembl:ENST00000429686|ensembl:ENSG00000186635(gene)|ensembl:ENST00000393609(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030037"(actin filament reorganization involved in cell cycle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051270"(regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|interpro:IPR000159(Ras-association)|interpro:IPR000198(RhoGAP)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037278|interpro:IPR037858|interpro:IPR038508|rcsb pdb:4X1V|reactome:R-HSA-8849469|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149	interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|mint:O00220|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENSG00000104689(gene)|ensembl:ENST00000221132(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005035"(death receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045569"(TRAIL binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|refseq:NP_003835.3	go:"GO:0005886"(plasma membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)	-	-	figure legend:3 A|comment:Upon TRAIL treatment, both ARAP1 and DR4 co-localized in early endosomes|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nctc)|taxid:9606(Homo sapiens skin epithelial-like cells)	-	2008/01/17	2014/10/16	rogid:AI7JgE3FapPBfnzcwT+AtENUXbg9606	rogid:utFDDi1uRCNlMUCt29SYzzar6Sc9606	intact-crc:9ED43F2C92955E3C|rigid:0LRBMxnQkxhQEf/r6vUGzAoVFIQ	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)