#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q547H1 uniprotkb:P62991 intact:EBI-7733331|intact:MINT-6179599 intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N psi-mi:q547h1_mouse(display_long)|uniprotkb:Ripk2(gene name)|psi-mi:Ripk2(display_short)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym) psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Hasegawa et al. (2008) pubmed:18079694|imex:IM-11525|mint:MINT-6179584 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7733326|mint:MINT-6179610|imex:IM-11525-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q547H1|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|refseq:NP_620402.1|dip:DIP-44657N|mint:MINT-6179612(identity) interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K|mint:MINT-6179613(identity) - comment:mint - figure legend:F1C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2008/02/15 2014/10/16 rogid:QmvlF8wotovBBFsfzPVjJ/2HIpE10090 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090 intact-crc:E346D0C4DE348347|rigid:VIMPZFcmxn2Kw288M0SGCz+54rE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q547H1 uniprotkb:P62991 intact:EBI-7733331|intact:MINT-6179599 intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N psi-mi:q547h1_mouse(display_long)|uniprotkb:Ripk2(gene name)|psi-mi:Ripk2(display_short)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym) psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hasegawa et al. (2008) pubmed:18079694|imex:IM-11525|mint:MINT-6179584 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7733415|mint:MINT-6179654|imex:IM-11525-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q547H1|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|refseq:NP_620402.1|dip:DIP-44657N|mint:MINT-6179656(identity) interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K|mint:MINT-6179660(identity) - comment:mint - comment:|figure legend:F5d|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2008/02/15 2014/10/16 rogid:QmvlF8wotovBBFsfzPVjJ/2HIpE10090 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090 intact-crc:DAC847E455A32695|rigid:VIMPZFcmxn2Kw288M0SGCz+54rE false mutation disrupting interaction:209-209(MINT-6179671)|ha tag:?-?(MINT-6179657) - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q547H1 uniprotkb:P62991 intact:EBI-7733331|intact:MINT-6179599 intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N psi-mi:q547h1_mouse(display_long)|uniprotkb:Ripk2(gene name)|psi-mi:Ripk2(display_short)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym) psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hasegawa et al. (2008) pubmed:18079694|imex:IM-11525|mint:MINT-6179584 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7733500|mint:MINT-6179619|imex:IM-11525-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q547H1|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|refseq:NP_620402.1|dip:DIP-44657N|mint:MINT-6179621(identity) interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K|mint:MINT-6179623(identity) - comment:mint - figure legend:F2A|comment:Cells were KF1B and MBP stimulated.|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2008/02/15 2014/10/16 rogid:QmvlF8wotovBBFsfzPVjJ/2HIpE10090 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090 intact-crc:9E3BA3C1F66B0A43|rigid:VIMPZFcmxn2Kw288M0SGCz+54rE false myc tag:?-?(MINT-6179632) mutation increasing interaction:48-48(MINT-6179628)|ha tag:?-?(MINT-6179626) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q547H1 uniprotkb:P62991 intact:EBI-7733331|intact:MINT-6179599 intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N psi-mi:q547h1_mouse(display_long)|uniprotkb:Ripk2(gene name)|psi-mi:Ripk2(display_short)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym) psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hasegawa et al. (2008) pubmed:18079694|imex:IM-11525|mint:MINT-6179584 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7733543|mint:MINT-6179636|imex:IM-11525-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q547H1|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|refseq:NP_620402.1|dip:DIP-44657N|mint:MINT-6179644(identity) interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K|mint:MINT-6179638(identity) - comment:mint - figure legend:F2A|comment:Cells were KF1B and MBP stimulated.|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2008/02/15 2014/10/16 rogid:QmvlF8wotovBBFsfzPVjJ/2HIpE10090 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090 intact-crc:7D787B4CCBC9C595|rigid:VIMPZFcmxn2Kw288M0SGCz+54rE false myc tag:?-?(MINT-6179645) mutation decreasing interaction:63-63(MINT-6179639)|ha tag:?-?(MINT-6179641) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)