#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49185	uniprotkb:P50232	intact:EBI-7456505|intact:MINT-1500743	intact:EBI-540118|ensembl:ENSRNOP00000023593	psi-mi:mk08_rat(display_long)|uniprotkb:Mapk8(gene name)|psi-mi:Mapk8(display_short)|uniprotkb:Jnk1(gene name synonym)|uniprotkb:Prkm8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:SAPK gamma(gene name synonym)|uniprotkb:p54 gamma(gene name synonym)	psi-mi:syt4_rat(display_long)|uniprotkb:Synaptotagmin IV(gene name synonym)|uniprotkb:Syt4(gene name)|psi-mi:Syt4(display_short)	psi-mi:"MI:0018"(two hybrid)	Mori et al. (2008)	pubmed:18046461|imex:IM-11528|mint:MINT-6276740	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7708858|mint:MINT-6379559|imex:IM-11528-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_446281.2|mint:P49185|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|rgd:621506|go:"GO:0001503"(ossification)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009408"(response to heat)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048666"(neuron development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902595"(regulation of DNA replication origin binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904809"(regulation of dense core granule transport)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001224"(positive regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|reactome:R-RNO-111446|reactome:R-RNO-139910|reactome:R-RNO-193648|reactome:R-RNO-2559580|reactome:R-RNO-2871796|reactome:R-RNO-376172|reactome:R-RNO-450321|reactome:R-RNO-450341|reactome:R-RNO-5693565|reactome:R-RNO-9007892|mint:MINT-6379561(identity)	rgd:68397|refseq:NP_113881.1|ensembl:ENSRNOG00000017333(gene)|ensembl:ENSRNOT00000023594(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098675"(intrinsic component of neuronal dense core vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099066"(integral component of neuronal dense core vesicle membrane)|go:"GO:0099161"(regulation of presynaptic dense core granule exocytosis)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099519"(dense core granule cytoskeletal transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905414"(negative regulation of dense core granule exocytosis)|go:"GO:1905415"(positive regulation of dense core granule exocytosis)|go:"GO:1905433"(negative regulation of retrograde trans-synaptic signaling by neuropeptide)|go:"GO:1990742"(microvesicle)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028683|interpro:IPR035892|mint:P50232|rcsb pdb:1W15|rcsb pdb:1W16|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0033604"(negative regulation of catecholamine secretion)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045202"(synapse)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048174"(negative regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061782"(vesicle fusion with vesicle)|go:"GO:0061792"(secretory granule maturation)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0006906"(vesicle fusion)|mint:MINT-6379562(identity)	-	function:"Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4 (HSF4)"|comment:mint	-	figure legend:F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/02/20	2014/10/16	rogid:wxHOU4BGM+BVCEKEwcYoNqxvIfo10116	rogid:w+c2IsLX0swLcv7N0u0/HeKznzo10116	intact-crc:1A743529B3A31053|rigid:IBAwC4MNjuScMDqiyF7CeXw2GZ4	false	tag:?-?(MINT-6379565)	tag:?-?(MINT-6379569)|binding-associated region:82-425(MINT-6379572)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49186	uniprotkb:P50232	intact:EBI-7708900|intact:MINT-5027617	intact:EBI-540118|ensembl:ENSRNOP00000023593	psi-mi:mk09_rat(display_long)|uniprotkb:Mapk9(gene name)|psi-mi:Mapk9(display_short)|uniprotkb:Jnk2(gene name synonym)|uniprotkb:Prkm9(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK2(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 2(gene name synonym)|uniprotkb:SAPK-alpha(gene name synonym)|uniprotkb:p54-alpha(gene name synonym)	psi-mi:syt4_rat(display_long)|uniprotkb:Synaptotagmin IV(gene name synonym)|uniprotkb:Syt4(gene name)|psi-mi:Syt4(display_short)	psi-mi:"MI:0018"(two hybrid)	Mori et al. (2008)	pubmed:18046461|imex:IM-11528|mint:MINT-6276740	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7708959|mint:MINT-6379575|imex:IM-11528-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009414"(response to water deprivation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010033"(response to organic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010770"(positive regulation of cell morphogenesis involved in differentiation)|go:"GO:0014075"(response to amine)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034644"(cellular response to UV)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990089"(response to nerve growth factor)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|reactome:R-RNO-2559580|reactome:R-RNO-2871796|reactome:R-RNO-450321|reactome:R-RNO-450341|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042493"|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048666"(neuron development)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|mint:P49186|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|rgd:628847|refseq:NP_059018.1|refseq:NP_001257473.1|interpro:IPR011009(Protein kinase-like)|mint:MINT-6379577(identity)	rgd:68397|refseq:NP_113881.1|ensembl:ENSRNOG00000017333(gene)|ensembl:ENSRNOT00000023594(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098675"(intrinsic component of neuronal dense core vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099066"(integral component of neuronal dense core vesicle membrane)|go:"GO:0099161"(regulation of presynaptic dense core granule exocytosis)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099519"(dense core granule cytoskeletal transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905414"(negative regulation of dense core granule exocytosis)|go:"GO:1905415"(positive regulation of dense core granule exocytosis)|go:"GO:1905433"(negative regulation of retrograde trans-synaptic signaling by neuropeptide)|go:"GO:1990742"(microvesicle)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028683|interpro:IPR035892|mint:P50232|rcsb pdb:1W15|rcsb pdb:1W16|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0033604"(negative regulation of catecholamine secretion)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045202"(synapse)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048174"(negative regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061782"(vesicle fusion with vesicle)|go:"GO:0061792"(secretory granule maturation)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0006906"(vesicle fusion)|mint:MINT-6379581(identity)	-	function:Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells|comment:mint	-	figure legend:F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/02/20	2014/10/16	rogid:5KW5jbcKGku0ui3P6UFabOPnx5810116	rogid:w+c2IsLX0swLcv7N0u0/HeKznzo10116	intact-crc:9D8A0C0A36EC9A1C|rigid:smRCGTPjATlYi/vVhLdD3vj8KHI	false	tag:?-?(MINT-6379578)	binding-associated region:82-425(MINT-6379582)|tag:?-?(MINT-6379584)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49187	uniprotkb:P50232	intact:EBI-7155513|uniprotkb:B0VXR6|uniprotkb:D3ZQ33|intact:MINT-151503	intact:EBI-540118|ensembl:ENSRNOP00000023593	psi-mi:mk10_rat(display_long)|uniprotkb:Mapk10(gene name)|psi-mi:Mapk10(display_short)|uniprotkb:Jnk3(gene name synonym)|uniprotkb:Prkm10(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK3(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 3(gene name synonym)|uniprotkb:SAPK-beta(gene name synonym)|uniprotkb:p54-beta(gene name synonym)	psi-mi:syt4_rat(display_long)|uniprotkb:Synaptotagmin IV(gene name synonym)|uniprotkb:Syt4(gene name)|psi-mi:Syt4(display_short)	psi-mi:"MI:0018"(two hybrid)	Mori et al. (2008)	pubmed:18046461|imex:IM-11528|mint:MINT-6276740	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7709001|mint:MINT-6379589|imex:IM-11528-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P49187|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009414"(response to water deprivation)|go:"GO:0009416"(response to light stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-2559580|reactome:R-RNO-2871796|reactome:R-RNO-450321|reactome:R-RNO-450341|rgd:3663|interpro:IPR011009(Protein kinase-like)|refseq:NP_036938.2|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|refseq:XP_017454572.1|mint:MINT-6379591(identity)	rgd:68397|refseq:NP_113881.1|ensembl:ENSRNOG00000017333(gene)|ensembl:ENSRNOT00000023594(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098675"(intrinsic component of neuronal dense core vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099066"(integral component of neuronal dense core vesicle membrane)|go:"GO:0099161"(regulation of presynaptic dense core granule exocytosis)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099519"(dense core granule cytoskeletal transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905414"(negative regulation of dense core granule exocytosis)|go:"GO:1905415"(positive regulation of dense core granule exocytosis)|go:"GO:1905433"(negative regulation of retrograde trans-synaptic signaling by neuropeptide)|go:"GO:1990742"(microvesicle)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028683|interpro:IPR035892|mint:P50232|rcsb pdb:1W15|rcsb pdb:1W16|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0033604"(negative regulation of catecholamine secretion)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045202"(synapse)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048174"(negative regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061782"(vesicle fusion with vesicle)|go:"GO:0061792"(secretory granule maturation)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0006906"(vesicle fusion)|mint:MINT-6379595(identity)	-	comment:mint|function:Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity	-	figure legend:F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/02/20	2018/09/18	rogid:sqyNbeKzu3ZGv3wKKrFoUvGiiSg10116	rogid:w+c2IsLX0swLcv7N0u0/HeKznzo10116	intact-crc:6FBFCC02F6157890|rigid:A7D/H0YHxtqu6I9vWjcQf7dLNUY	false	tag:?-?(MINT-6379592)	binding-associated region:82-425(MINT-6379598)|tag:?-?(MINT-6379596)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49185	uniprotkb:P50232	intact:EBI-7456505|intact:MINT-1500743	intact:EBI-540118|ensembl:ENSRNOP00000023593	psi-mi:mk08_rat(display_long)|uniprotkb:Mapk8(gene name)|psi-mi:Mapk8(display_short)|uniprotkb:Jnk1(gene name synonym)|uniprotkb:Prkm8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:SAPK gamma(gene name synonym)|uniprotkb:p54 gamma(gene name synonym)	psi-mi:syt4_rat(display_long)|uniprotkb:Synaptotagmin IV(gene name synonym)|uniprotkb:Syt4(gene name)|psi-mi:Syt4(display_short)	psi-mi:"MI:0096"(pull down)	Mori et al. (2008)	pubmed:18046461|imex:IM-11528|mint:MINT-6276740	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7709071|mint:MINT-6379606|imex:IM-11528-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_446281.2|mint:P49185|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|rgd:621506|go:"GO:0001503"(ossification)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009408"(response to heat)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048666"(neuron development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902595"(regulation of DNA replication origin binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904809"(regulation of dense core granule transport)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001224"(positive regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|reactome:R-RNO-111446|reactome:R-RNO-139910|reactome:R-RNO-193648|reactome:R-RNO-2559580|reactome:R-RNO-2871796|reactome:R-RNO-376172|reactome:R-RNO-450321|reactome:R-RNO-450341|reactome:R-RNO-5693565|reactome:R-RNO-9007892|mint:MINT-6379608(identity)	rgd:68397|refseq:NP_113881.1|ensembl:ENSRNOG00000017333(gene)|ensembl:ENSRNOT00000023594(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098675"(intrinsic component of neuronal dense core vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099066"(integral component of neuronal dense core vesicle membrane)|go:"GO:0099161"(regulation of presynaptic dense core granule exocytosis)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099519"(dense core granule cytoskeletal transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905414"(negative regulation of dense core granule exocytosis)|go:"GO:1905415"(positive regulation of dense core granule exocytosis)|go:"GO:1905433"(negative regulation of retrograde trans-synaptic signaling by neuropeptide)|go:"GO:1990742"(microvesicle)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028683|interpro:IPR035892|mint:P50232|rcsb pdb:1W15|rcsb pdb:1W16|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0033604"(negative regulation of catecholamine secretion)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045202"(synapse)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048174"(negative regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061782"(vesicle fusion with vesicle)|go:"GO:0061792"(secretory granule maturation)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0006906"(vesicle fusion)|mint:MINT-6379612(identity)	-	function:"Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4 (HSF4)"|comment:mint	-	figure legend:F2C F2D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:wxHOU4BGM+BVCEKEwcYoNqxvIfo10116	rogid:w+c2IsLX0swLcv7N0u0/HeKznzo10116	intact-crc:3BB24B15B9081709|rigid:IBAwC4MNjuScMDqiyF7CeXw2GZ4	false	mutation decreasing interaction:162-162(MINT-6379627)|flag tag:?-?(MINT-6379609)	glutathione s tranferase tag:?-?(MINT-6379615)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49185	uniprotkb:P50232	intact:EBI-7456505|intact:MINT-1500743	intact:EBI-540118|ensembl:ENSRNOP00000023593	psi-mi:mk08_rat(display_long)|uniprotkb:Mapk8(gene name)|psi-mi:Mapk8(display_short)|uniprotkb:Jnk1(gene name synonym)|uniprotkb:Prkm8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:SAPK gamma(gene name synonym)|uniprotkb:p54 gamma(gene name synonym)	psi-mi:syt4_rat(display_long)|uniprotkb:Synaptotagmin IV(gene name synonym)|uniprotkb:Syt4(gene name)|psi-mi:Syt4(display_short)	psi-mi:"MI:0096"(pull down)	Mori et al. (2008)	pubmed:18046461|imex:IM-11528|mint:MINT-6276740	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7709157|mint:MINT-6379631|imex:IM-11528-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_446281.2|mint:P49185|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|rgd:621506|go:"GO:0001503"(ossification)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009408"(response to heat)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048666"(neuron development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902595"(regulation of DNA replication origin binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904809"(regulation of dense core granule transport)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001224"(positive regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|reactome:R-RNO-111446|reactome:R-RNO-139910|reactome:R-RNO-193648|reactome:R-RNO-2559580|reactome:R-RNO-2871796|reactome:R-RNO-376172|reactome:R-RNO-450321|reactome:R-RNO-450341|reactome:R-RNO-5693565|reactome:R-RNO-9007892|mint:MINT-6379633(identity)	rgd:68397|refseq:NP_113881.1|ensembl:ENSRNOG00000017333(gene)|ensembl:ENSRNOT00000023594(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098675"(intrinsic component of neuronal dense core vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099066"(integral component of neuronal dense core vesicle membrane)|go:"GO:0099161"(regulation of presynaptic dense core granule exocytosis)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099519"(dense core granule cytoskeletal transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905414"(negative regulation of dense core granule exocytosis)|go:"GO:1905415"(positive regulation of dense core granule exocytosis)|go:"GO:1905433"(negative regulation of retrograde trans-synaptic signaling by neuropeptide)|go:"GO:1990742"(microvesicle)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028683|interpro:IPR035892|mint:P50232|rcsb pdb:1W15|rcsb pdb:1W16|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0033604"(negative regulation of catecholamine secretion)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045202"(synapse)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048174"(negative regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061782"(vesicle fusion with vesicle)|go:"GO:0061792"(secretory granule maturation)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0006906"(vesicle fusion)|mint:MINT-6379639(identity)	-	function:"Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4 (HSF4)"|comment:mint	-	figure legend:F2C F2D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:wxHOU4BGM+BVCEKEwcYoNqxvIfo10116	rogid:w+c2IsLX0swLcv7N0u0/HeKznzo10116	intact-crc:F20265FE269011FA|rigid:IBAwC4MNjuScMDqiyF7CeXw2GZ4	false	mutation disrupting interaction:329-329(MINT-6379659)|flag tag:?-?(MINT-6379636)|mutation disrupting interaction:162-162(MINT-6379634)|mutation disrupting interaction:331-331(MINT-6379662)|mutation disrupting interaction:326-326(MINT-6379656)	glutathione s tranferase tag:?-?(MINT-6379640)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49185	uniprotkb:P50232	intact:EBI-7456505|intact:MINT-1500743	intact:EBI-540118|ensembl:ENSRNOP00000023593	psi-mi:mk08_rat(display_long)|uniprotkb:Mapk8(gene name)|psi-mi:Mapk8(display_short)|uniprotkb:Jnk1(gene name synonym)|uniprotkb:Prkm8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:SAPK gamma(gene name synonym)|uniprotkb:p54 gamma(gene name synonym)	psi-mi:syt4_rat(display_long)|uniprotkb:Synaptotagmin IV(gene name synonym)|uniprotkb:Syt4(gene name)|psi-mi:Syt4(display_short)	psi-mi:"MI:0096"(pull down)	Mori et al. (2008)	pubmed:18046461|imex:IM-11528|mint:MINT-6276740	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7709204|mint:MINT-6379666|imex:IM-11528-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_446281.2|mint:P49185|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|rgd:621506|go:"GO:0001503"(ossification)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009408"(response to heat)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048666"(neuron development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902595"(regulation of DNA replication origin binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904809"(regulation of dense core granule transport)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001224"(positive regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|reactome:R-RNO-111446|reactome:R-RNO-139910|reactome:R-RNO-193648|reactome:R-RNO-2559580|reactome:R-RNO-2871796|reactome:R-RNO-376172|reactome:R-RNO-450321|reactome:R-RNO-450341|reactome:R-RNO-5693565|reactome:R-RNO-9007892|mint:MINT-6379672(identity)	rgd:68397|refseq:NP_113881.1|ensembl:ENSRNOG00000017333(gene)|ensembl:ENSRNOT00000023594(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098675"(intrinsic component of neuronal dense core vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099066"(integral component of neuronal dense core vesicle membrane)|go:"GO:0099161"(regulation of presynaptic dense core granule exocytosis)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099519"(dense core granule cytoskeletal transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905414"(negative regulation of dense core granule exocytosis)|go:"GO:1905415"(positive regulation of dense core granule exocytosis)|go:"GO:1905433"(negative regulation of retrograde trans-synaptic signaling by neuropeptide)|go:"GO:1990742"(microvesicle)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028683|interpro:IPR035892|mint:P50232|rcsb pdb:1W15|rcsb pdb:1W16|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0033604"(negative regulation of catecholamine secretion)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045202"(synapse)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048174"(negative regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061782"(vesicle fusion with vesicle)|go:"GO:0061792"(secretory granule maturation)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0006906"(vesicle fusion)|mint:MINT-6379668(identity)	-	function:"Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4 (HSF4)"|comment:mint	-	figure legend:F2C F2D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:wxHOU4BGM+BVCEKEwcYoNqxvIfo10116	rogid:w+c2IsLX0swLcv7N0u0/HeKznzo10116	intact-crc:ACB790CC84941A99|rigid:IBAwC4MNjuScMDqiyF7CeXw2GZ4	false	flag tag:?-?(MINT-6379681)|mutation decreasing interaction:331-331(MINT-6379673)|mutation decreasing interaction:326-326(MINT-6379677)|mutation decreasing interaction:329-329(MINT-6379675)	glutathione s tranferase tag:?-?(MINT-6379669)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49187	uniprotkb:P50232	intact:EBI-7155513|uniprotkb:B0VXR6|uniprotkb:D3ZQ33|intact:MINT-151503	intact:EBI-540118|ensembl:ENSRNOP00000023593	psi-mi:mk10_rat(display_long)|uniprotkb:Mapk10(gene name)|psi-mi:Mapk10(display_short)|uniprotkb:Jnk3(gene name synonym)|uniprotkb:Prkm10(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK3(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 3(gene name synonym)|uniprotkb:SAPK-beta(gene name synonym)|uniprotkb:p54-beta(gene name synonym)	psi-mi:syt4_rat(display_long)|uniprotkb:Synaptotagmin IV(gene name synonym)|uniprotkb:Syt4(gene name)|psi-mi:Syt4(display_short)	psi-mi:"MI:0096"(pull down)	Mori et al. (2008)	pubmed:18046461|imex:IM-11528|mint:MINT-6276740	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7709237|mint:MINT-6379687|imex:IM-11528-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P49187|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009414"(response to water deprivation)|go:"GO:0009416"(response to light stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-2559580|reactome:R-RNO-2871796|reactome:R-RNO-450321|reactome:R-RNO-450341|rgd:3663|interpro:IPR011009(Protein kinase-like)|refseq:NP_036938.2|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|refseq:XP_017454572.1|mint:MINT-6379689(identity)	rgd:68397|refseq:NP_113881.1|ensembl:ENSRNOG00000017333(gene)|ensembl:ENSRNOT00000023594(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098675"(intrinsic component of neuronal dense core vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099066"(integral component of neuronal dense core vesicle membrane)|go:"GO:0099161"(regulation of presynaptic dense core granule exocytosis)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099519"(dense core granule cytoskeletal transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905414"(negative regulation of dense core granule exocytosis)|go:"GO:1905415"(positive regulation of dense core granule exocytosis)|go:"GO:1905433"(negative regulation of retrograde trans-synaptic signaling by neuropeptide)|go:"GO:1990742"(microvesicle)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028683|interpro:IPR035892|mint:P50232|rcsb pdb:1W15|rcsb pdb:1W16|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0033604"(negative regulation of catecholamine secretion)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045202"(synapse)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048174"(negative regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061782"(vesicle fusion with vesicle)|go:"GO:0061792"(secretory granule maturation)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0006906"(vesicle fusion)|mint:MINT-6379695(identity)	-	comment:mint|function:Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity	-	figure legend:F2C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2018/09/18	rogid:sqyNbeKzu3ZGv3wKKrFoUvGiiSg10116	rogid:w+c2IsLX0swLcv7N0u0/HeKznzo10116	intact-crc:75AC8AA82826DACD|rigid:A7D/H0YHxtqu6I9vWjcQf7dLNUY	false	flag tag:?-?(MINT-6379692)	glutathione s tranferase tag:?-?(MINT-6379696)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49185	uniprotkb:P17325	intact:EBI-7456505|intact:MINT-1500743	intact:EBI-7709365|ensembl:ENSRNOP00000011732|intact:MINT-220059	psi-mi:mk08_rat(display_long)|uniprotkb:Mapk8(gene name)|psi-mi:Mapk8(display_short)|uniprotkb:Jnk1(gene name synonym)|uniprotkb:Prkm8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:SAPK gamma(gene name synonym)|uniprotkb:p54 gamma(gene name synonym)	psi-mi:jun_rat(display_long)|uniprotkb:Jun(gene name)|psi-mi:Jun(display_short)|uniprotkb:Rjg-9(gene name synonym)|uniprotkb:Activator protein 1(gene name synonym)|uniprotkb:V-jun avian sarcoma virus 17 oncogene homolog(gene name synonym)|uniprotkb:Proto-oncogene c-Jun(gene name synonym)	psi-mi:"MI:0096"(pull down)	Mori et al. (2008)	pubmed:18046461|imex:IM-11528|mint:MINT-6276740	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7709442|mint:MINT-6379704|imex:IM-11528-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_446281.2|mint:P49185|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|rgd:621506|go:"GO:0001503"(ossification)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009408"(response to heat)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048666"(neuron development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902595"(regulation of DNA replication origin binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904809"(regulation of dense core granule transport)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001224"(positive regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|reactome:R-RNO-111446|reactome:R-RNO-139910|reactome:R-RNO-193648|reactome:R-RNO-2559580|reactome:R-RNO-2871796|reactome:R-RNO-376172|reactome:R-RNO-450321|reactome:R-RNO-450341|reactome:R-RNO-5693565|reactome:R-RNO-9007892|mint:MINT-6379710(identity)	go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|ensembl:ENSRNOG00000026293(gene)|ensembl:ENSRNOT00000011731(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001889"(liver development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009987"(cellular process)|go:"GO:0010033"(response to organic substance)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051365"(cellular response to potassium ion starvation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR002112(Transcription factor Jun)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR005643(Jun-like transcription factor)|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR015558(c-Jun Transcription Factor)|mint:P17325|reactome:R-RNO-2559580|reactome:R-RNO-2871796|reactome:R-RNO-450341|rgd:2943|refseq:NP_068607.1|dip:DIP-653N|mint:MINT-6379706(identity)	-	function:"Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4 (HSF4)"|comment:mint	comment:mint|function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'	figure legend:F2C F2E|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:wxHOU4BGM+BVCEKEwcYoNqxvIfo10116	rogid:u51ezRU+hzE0HvWZnsbAJ9sTd8s10116	intact-crc:5B1BA840532E971B|rigid:Fz39gyVJaYMDMIzGwmA3tb6eQc0	false	flag tag:?-?(MINT-6379719)|mutation disrupting interaction:162-162(MINT-6379717)|mutation disrupting interaction:326-326(MINT-6379715)|mutation disrupting interaction:331-331(MINT-6379711)|mutation disrupting interaction:329-329(MINT-6379713)	glutathione s tranferase tag:?-?(MINT-6379707)|binding-associated region:1-79(MINT-6379727)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49186	uniprotkb:P17325	intact:EBI-7708900|intact:MINT-5027617	intact:EBI-7709365|ensembl:ENSRNOP00000011732|intact:MINT-220059	psi-mi:mk09_rat(display_long)|uniprotkb:Mapk9(gene name)|psi-mi:Mapk9(display_short)|uniprotkb:Jnk2(gene name synonym)|uniprotkb:Prkm9(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK2(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 2(gene name synonym)|uniprotkb:SAPK-alpha(gene name synonym)|uniprotkb:p54-alpha(gene name synonym)	psi-mi:jun_rat(display_long)|uniprotkb:Jun(gene name)|psi-mi:Jun(display_short)|uniprotkb:Rjg-9(gene name synonym)|uniprotkb:Activator protein 1(gene name synonym)|uniprotkb:V-jun avian sarcoma virus 17 oncogene homolog(gene name synonym)|uniprotkb:Proto-oncogene c-Jun(gene name synonym)	psi-mi:"MI:0096"(pull down)	Mori et al. (2008)	pubmed:18046461|imex:IM-11528|mint:MINT-6276740	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7709576|mint:MINT-6379752|imex:IM-11528-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009414"(response to water deprivation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010033"(response to organic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010770"(positive regulation of cell morphogenesis involved in differentiation)|go:"GO:0014075"(response to amine)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034644"(cellular response to UV)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990089"(response to nerve growth factor)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|reactome:R-RNO-2559580|reactome:R-RNO-2871796|reactome:R-RNO-450321|reactome:R-RNO-450341|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042493"|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048666"(neuron development)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|mint:P49186|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|rgd:628847|refseq:NP_059018.1|refseq:NP_001257473.1|interpro:IPR011009(Protein kinase-like)|mint:MINT-6379754(identity)	go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|ensembl:ENSRNOG00000026293(gene)|ensembl:ENSRNOT00000011731(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001889"(liver development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009987"(cellular process)|go:"GO:0010033"(response to organic substance)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051365"(cellular response to potassium ion starvation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR002112(Transcription factor Jun)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR005643(Jun-like transcription factor)|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR015558(c-Jun Transcription Factor)|mint:P17325|reactome:R-RNO-2559580|reactome:R-RNO-2871796|reactome:R-RNO-450341|rgd:2943|refseq:NP_068607.1|dip:DIP-653N|mint:MINT-6379764(identity)	-	function:Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells|comment:mint	comment:mint|function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'	figure legend:F2C F2E|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:5KW5jbcKGku0ui3P6UFabOPnx5810116	rogid:u51ezRU+hzE0HvWZnsbAJ9sTd8s10116	intact-crc:19C471E90EDE3D44|rigid:ppVGIH6I1uPfw6/YZU5Vb4GZ1Uo	false	flag tag:?-?(MINT-6379761)	glutathione s tranferase tag:?-?(MINT-6379765)|binding-associated region:1-79(MINT-6379767)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49185	uniprotkb:P17325	intact:EBI-7456505|intact:MINT-1500743	intact:EBI-7709365|ensembl:ENSRNOP00000011732|intact:MINT-220059	psi-mi:mk08_rat(display_long)|uniprotkb:Mapk8(gene name)|psi-mi:Mapk8(display_short)|uniprotkb:Jnk1(gene name synonym)|uniprotkb:Prkm8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:SAPK gamma(gene name synonym)|uniprotkb:p54 gamma(gene name synonym)	psi-mi:jun_rat(display_long)|uniprotkb:Jun(gene name)|psi-mi:Jun(display_short)|uniprotkb:Rjg-9(gene name synonym)|uniprotkb:Activator protein 1(gene name synonym)|uniprotkb:V-jun avian sarcoma virus 17 oncogene homolog(gene name synonym)|uniprotkb:Proto-oncogene c-Jun(gene name synonym)	psi-mi:"MI:0096"(pull down)	Mori et al. (2008)	pubmed:18046461|imex:IM-11528|mint:MINT-6276740	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7709539|mint:MINT-6379730|imex:IM-11528-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_446281.2|mint:P49185|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|rgd:621506|go:"GO:0001503"(ossification)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009408"(response to heat)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048666"(neuron development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902595"(regulation of DNA replication origin binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904809"(regulation of dense core granule transport)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001224"(positive regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|reactome:R-RNO-111446|reactome:R-RNO-139910|reactome:R-RNO-193648|reactome:R-RNO-2559580|reactome:R-RNO-2871796|reactome:R-RNO-376172|reactome:R-RNO-450321|reactome:R-RNO-450341|reactome:R-RNO-5693565|reactome:R-RNO-9007892|mint:MINT-6379738(identity)	go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|ensembl:ENSRNOG00000026293(gene)|ensembl:ENSRNOT00000011731(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001889"(liver development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009987"(cellular process)|go:"GO:0010033"(response to organic substance)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051365"(cellular response to potassium ion starvation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR002112(Transcription factor Jun)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR005643(Jun-like transcription factor)|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR015558(c-Jun Transcription Factor)|mint:P17325|reactome:R-RNO-2559580|reactome:R-RNO-2871796|reactome:R-RNO-450341|rgd:2943|refseq:NP_068607.1|dip:DIP-653N|mint:MINT-6379732(identity)	-	function:"Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4 (HSF4)"|comment:mint	comment:mint|function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'	figure legend:F2C F2E|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:wxHOU4BGM+BVCEKEwcYoNqxvIfo10116	rogid:u51ezRU+hzE0HvWZnsbAJ9sTd8s10116	intact-crc:9CC23002761A8D5A|rigid:Fz39gyVJaYMDMIzGwmA3tb6eQc0	false	flag tag:?-?(MINT-6379739)|mutation decreasing interaction:329-329(MINT-6379745)|mutation decreasing interaction:331-331(MINT-6379747)|mutation decreasing interaction:326-326(MINT-6379743)	binding-associated region:1-79(MINT-6379733)|glutathione s tranferase tag:?-?(MINT-6379735)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49185	uniprotkb:P50232	intact:EBI-7456505|intact:MINT-1500743	intact:EBI-540118|ensembl:ENSRNOP00000023593	psi-mi:mk08_rat(display_long)|uniprotkb:Mapk8(gene name)|psi-mi:Mapk8(display_short)|uniprotkb:Jnk1(gene name synonym)|uniprotkb:Prkm8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:SAPK gamma(gene name synonym)|uniprotkb:p54 gamma(gene name synonym)	psi-mi:syt4_rat(display_long)|uniprotkb:Synaptotagmin IV(gene name synonym)|uniprotkb:Syt4(gene name)|psi-mi:Syt4(display_short)	psi-mi:"MI:0096"(pull down)	Mori et al. (2008)	pubmed:18046461|imex:IM-11528|mint:MINT-6276740	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7709633|mint:MINT-6379774|imex:IM-11528-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_446281.2|mint:P49185|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|rgd:621506|go:"GO:0001503"(ossification)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009408"(response to heat)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048666"(neuron development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902595"(regulation of DNA replication origin binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904809"(regulation of dense core granule transport)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001224"(positive regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|reactome:R-RNO-111446|reactome:R-RNO-139910|reactome:R-RNO-193648|reactome:R-RNO-2559580|reactome:R-RNO-2871796|reactome:R-RNO-376172|reactome:R-RNO-450321|reactome:R-RNO-450341|reactome:R-RNO-5693565|reactome:R-RNO-9007892|mint:MINT-6379776(identity)	rgd:68397|refseq:NP_113881.1|ensembl:ENSRNOG00000017333(gene)|ensembl:ENSRNOT00000023594(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098675"(intrinsic component of neuronal dense core vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099066"(integral component of neuronal dense core vesicle membrane)|go:"GO:0099161"(regulation of presynaptic dense core granule exocytosis)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099519"(dense core granule cytoskeletal transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905414"(negative regulation of dense core granule exocytosis)|go:"GO:1905415"(positive regulation of dense core granule exocytosis)|go:"GO:1905433"(negative regulation of retrograde trans-synaptic signaling by neuropeptide)|go:"GO:1990742"(microvesicle)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028683|interpro:IPR035892|mint:P50232|rcsb pdb:1W15|rcsb pdb:1W16|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0033604"(negative regulation of catecholamine secretion)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045202"(synapse)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048174"(negative regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061782"(vesicle fusion with vesicle)|go:"GO:0061792"(secretory granule maturation)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0006906"(vesicle fusion)|mint:MINT-6379782(identity)	-	function:"Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4 (HSF4)"|comment:mint	-	comment:homomint|comment:mint|figure legend:F2G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:wxHOU4BGM+BVCEKEwcYoNqxvIfo10116	rogid:w+c2IsLX0swLcv7N0u0/HeKznzo10116	intact-crc:00F1AC8E033B1575|rigid:IBAwC4MNjuScMDqiyF7CeXw2GZ4	false	flag tag:?-?(MINT-6379779)	binding-associated region:82-275(MINT-6379788)|glutathione s tranferase tag:?-?(MINT-6379783)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21707	uniprotkb:P50232	intact:EBI-458098|uniprotkb:Q3S2E6|uniprotkb:Q707P5|ensembl:ENSRNOP00000049624|ensembl:ENSRNOP00000069194	intact:EBI-540118|ensembl:ENSRNOP00000023593	psi-mi:syt1_rat(display_long)|uniprotkb:Syt1(gene name)|psi-mi:Syt1(display_short)|uniprotkb:Synaptotagmin I(gene name synonym)|uniprotkb:p65(gene name synonym)	psi-mi:syt4_rat(display_long)|uniprotkb:Synaptotagmin IV(gene name synonym)|uniprotkb:Syt4(gene name)|psi-mi:Syt4(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Mori et al. (2008)	pubmed:18046461|imex:IM-11528|mint:MINT-6276740	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7709757|mint:MINT-6379955|imex:IM-11528-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3803|refseq:NP_001028852.2|ensembl:ENSRNOG00000006426(gene)|ensembl:ENSRNOT00000048880(transcript)|ensembl:ENSRNOT00000088950(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051291"(protein heterooligomerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0061891"(calcium ion sensor activity)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071911"(synchronous neurotransmitter secretion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098746"(fast, calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903235"(positive regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903305"(regulation of regulated secretory pathway)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|mint:P21707|rcsb pdb:1BYN|rcsb pdb:1K5W|rcsb pdb:1RSY|rcsb pdb:1TJM|rcsb pdb:1TJX|rcsb pdb:1UOV|rcsb pdb:1UOW|rcsb pdb:2YOA|rcsb pdb:4WEE|rcsb pdb:5CCG|rcsb pdb:5CCH|rcsb pdb:5CCI|rcsb pdb:5CCJ|rcsb pdb:5KJ7|rcsb pdb:5KJ8|rcsb pdb:5W5C|rcsb pdb:5W5D|rcsb pdb:6CXW|rcsb pdb:6MTI|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-888590|refseq:XP_017450168.1|dip:DIP-29064N|mint:MINT-6379957(identity)	rgd:68397|refseq:NP_113881.1|ensembl:ENSRNOG00000017333(gene)|ensembl:ENSRNOT00000023594(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098675"(intrinsic component of neuronal dense core vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099066"(integral component of neuronal dense core vesicle membrane)|go:"GO:0099161"(regulation of presynaptic dense core granule exocytosis)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099519"(dense core granule cytoskeletal transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905414"(negative regulation of dense core granule exocytosis)|go:"GO:1905415"(positive regulation of dense core granule exocytosis)|go:"GO:1905433"(negative regulation of retrograde trans-synaptic signaling by neuropeptide)|go:"GO:1990742"(microvesicle)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028683|interpro:IPR035892|mint:P50232|rcsb pdb:1W15|rcsb pdb:1W16|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0033604"(negative regulation of catecholamine secretion)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045202"(synapse)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048174"(negative regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061782"(vesicle fusion with vesicle)|go:"GO:0061792"(secretory granule maturation)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0006906"(vesicle fusion)|mint:MINT-6379958(identity)	go:"GO:0030140"(trans-Golgi network transport vesicle)	-	-	figure legend:F6A|comment:Cells were treated with NGF.|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2008/02/20	2014/10/16	rogid:fr7zfj22zAOY/bJ7psjrgnsb0g810116	rogid:w+c2IsLX0swLcv7N0u0/HeKznzo10116	intact-crc:99D6DCC634813B60|rigid:2qDbl3xvHmkc0JkJopLx/6q5LH8	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P21707	uniprotkb:P50232	intact:EBI-458098|uniprotkb:Q3S2E6|uniprotkb:Q707P5|ensembl:ENSRNOP00000049624|ensembl:ENSRNOP00000069194	intact:EBI-540118|ensembl:ENSRNOP00000023593	psi-mi:syt1_rat(display_long)|uniprotkb:Syt1(gene name)|psi-mi:Syt1(display_short)|uniprotkb:Synaptotagmin I(gene name synonym)|uniprotkb:p65(gene name synonym)	psi-mi:syt4_rat(display_long)|uniprotkb:Synaptotagmin IV(gene name synonym)|uniprotkb:Syt4(gene name)|psi-mi:Syt4(display_short)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Mori et al. (2008)	pubmed:18046461|imex:IM-11528|mint:MINT-6276740	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7709803|mint:MINT-6379970|imex:IM-11528-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3803|refseq:NP_001028852.2|ensembl:ENSRNOG00000006426(gene)|ensembl:ENSRNOT00000048880(transcript)|ensembl:ENSRNOT00000088950(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051291"(protein heterooligomerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0061891"(calcium ion sensor activity)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071911"(synchronous neurotransmitter secretion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098746"(fast, calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903235"(positive regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903305"(regulation of regulated secretory pathway)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|mint:P21707|rcsb pdb:1BYN|rcsb pdb:1K5W|rcsb pdb:1RSY|rcsb pdb:1TJM|rcsb pdb:1TJX|rcsb pdb:1UOV|rcsb pdb:1UOW|rcsb pdb:2YOA|rcsb pdb:4WEE|rcsb pdb:5CCG|rcsb pdb:5CCH|rcsb pdb:5CCI|rcsb pdb:5CCJ|rcsb pdb:5KJ7|rcsb pdb:5KJ8|rcsb pdb:5W5C|rcsb pdb:5W5D|rcsb pdb:6CXW|rcsb pdb:6MTI|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-888590|refseq:XP_017450168.1|dip:DIP-29064N|mint:MINT-6379975(identity)	rgd:68397|refseq:NP_113881.1|ensembl:ENSRNOG00000017333(gene)|ensembl:ENSRNOT00000023594(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098675"(intrinsic component of neuronal dense core vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099066"(integral component of neuronal dense core vesicle membrane)|go:"GO:0099161"(regulation of presynaptic dense core granule exocytosis)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099519"(dense core granule cytoskeletal transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905414"(negative regulation of dense core granule exocytosis)|go:"GO:1905415"(positive regulation of dense core granule exocytosis)|go:"GO:1905433"(negative regulation of retrograde trans-synaptic signaling by neuropeptide)|go:"GO:1990742"(microvesicle)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028683|interpro:IPR035892|mint:P50232|rcsb pdb:1W15|rcsb pdb:1W16|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0033604"(negative regulation of catecholamine secretion)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045202"(synapse)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048174"(negative regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061782"(vesicle fusion with vesicle)|go:"GO:0061792"(secretory granule maturation)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0006906"(vesicle fusion)|mint:MINT-6379973(identity)	-	-	-	figure legend:F7|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2008/02/20	2014/10/16	rogid:fr7zfj22zAOY/bJ7psjrgnsb0g810116	rogid:w+c2IsLX0swLcv7N0u0/HeKznzo10116	intact-crc:4FCA3C240B96BB4F|rigid:2qDbl3xvHmkc0JkJopLx/6q5LH8	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)