#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706124|mint:MINT-6380974|imex:IM-11533-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6380977(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6380976(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F1C F3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:F3DA7207AF7B5D85|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	-	binding-associated region:?-?(MINT-6380986)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706212|mint:MINT-6381034|imex:IM-11533-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6381036(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6381038(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F4 T2|comment:"KA(affinity constant)= 0.93 x 10^8/M  The IGF2R-Dom10 13, IGF2R-Dom11 13 and IGF2R-Dom11 14 fragments were coupled directly to a biosensor surface via amine groups to give a final resonance value of 2000 U."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:FEF59134CE958540|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	mutation decreasing interaction:48-48(MINT-6381055)	binding-associated region:?-?(MINT-6381039)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706171|mint:MINT-6380995|imex:IM-11533-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6380997(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6380999(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F4 T2|comment:"KA(affinity constant)= 2.49 x 10^8/M  The IGF2R-Dom10 13, IGF2R-Dom11 13 and IGF2R-Dom11 14 fragments were coupled directly to a biosensor surface via amine groups to give a final resonance value of 2000 U."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:AFE47BDC30DD38F7|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	-	binding-associated region:?-?(MINT-6381000)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706258|mint:MINT-6381176|imex:IM-11533-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6381183(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6381178(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F4 T2|comment:"KA(affinity constant)= 0.91 x 10^8/M  The IGF2R-Dom10 13, IGF2R-Dom11 13 and IGF2R-Dom11 14 fragments were coupled directly to a biosensor surface via amine groups to give a final resonance value of 2000 U."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:290C92F602BFC3AB|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	mutation decreasing interaction:49-49(MINT-6381184)	binding-associated region:?-?(MINT-6381179)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706284|mint:MINT-6381202|imex:IM-11533-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6381204(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6381208(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F4 T2|comment:"KA(affinity constant)= 0.56 x 10^8/M  The IGF2R-Dom10 13, IGF2R-Dom11 13 and IGF2R-Dom11 14 fragments were coupled directly to a biosensor surface via amine groups to give a final resonance value of 2000 U."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:8C55C553ABBF1C9C|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	mutation decreasing interaction:8-8(MINT-6381205)	binding-associated region:?-?(MINT-6381209)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706330|mint:MINT-6381218|imex:IM-11533-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6381225(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6381220(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F4 T2|comment:"KA(affinity constant)= 2.01 x 10^8/M  The IGF2R-Dom10 13, IGF2R-Dom11 13 and IGF2R-Dom11 14 fragments were coupled directly to a biosensor surface via amine groups to give a final resonance value of 2000 U."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:6F8AB080BC620D3F|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	-	binding-associated region:?-?(MINT-6381221)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706373|mint:MINT-6381259|imex:IM-11533-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6381261(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6381263(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F4 T2|comment:"KA(affinity constant)= 0.66 x 10^8/M  The IGF2R-Dom10 13, IGF2R-Dom11 13 and IGF2R-Dom11 14 fragments were coupled directly to a biosensor surface via amine groups to give a final resonance value of 2000 U."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:BD638000F8686272|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	mutation decreasing interaction:49-49(MINT-6381271)	binding-associated region:?-?(MINT-6381264)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706545|mint:MINT-6381282|imex:IM-11533-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6381289(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6381284(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F4 T2|comment:"KA(affinity constant)= 0.31 x 10^8/M  The IGF2R-Dom10 13, IGF2R-Dom11 13 and IGF2R-Dom11 14 fragments were coupled directly to a biosensor surface via amine groups to give a final resonance value of 2000 U."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:1DCC77335707D4BA|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	mutation decreasing interaction:8-8(MINT-6381290)	binding-associated region:?-?(MINT-6381285)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706627|mint:MINT-6381394|imex:IM-11533-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6381401(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6381396(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F4 T2|comment:"KA(affinity constant)= 1.82 x 10^8/M  The IGF2R-Dom10 13, IGF2R-Dom11 13 and IGF2R-Dom11 14 fragments were coupled directly to a biosensor surface via amine groups to give a final resonance value of 2000 U."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:CAD7B0964E482012|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	-	binding-associated region:?-?(MINT-6381397)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706591|mint:MINT-6381323|imex:IM-11533-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6381325(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6381329(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F4 T2|comment:"KA(affinity constant)= 0.53 x 10^8/M  The IGF2R-Dom10 13, IGF2R-Dom11 13 and IGF2R-Dom11 14 fragments were coupled directly to a biosensor surface via amine groups to give a final resonance value of 2000 U."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:8204611F56005E13|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	mutation decreasing interaction:50-50(MINT-6381371)|mutation decreasing interaction:48-48(MINT-6381326)|mutation decreasing interaction:49-49(MINT-6381369)	binding-associated region:?-?(MINT-6381330)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706704|mint:MINT-6381450|imex:IM-11533-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6381457(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6381452(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F4 T2|comment:"KA(affinity constant)= 0.22 x 10^8/M  The IGF2R-Dom10 13, IGF2R-Dom11 13 and IGF2R-Dom11 14 fragments were coupled directly to a biosensor surface via amine groups to give a final resonance value of 2000 U."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:0187E64F4373FCA7|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	mutation decreasing interaction:8-8(MINT-6381458)	binding-associated region:?-?(MINT-6381453)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706668|mint:MINT-6381420|imex:IM-11533-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6381427(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6381422(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F4 T2|comment:"KA(affinity constant)= 0.12 x 10^8/M  The IGF2R-Dom10 13, IGF2R-Dom11 13 and IGF2R-Dom11 14 fragments were coupled directly to a biosensor surface via amine groups to give a final resonance value of 2000 U."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:2B0AF1878250C60F|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	mutation decreasing interaction:48-48(MINT-6381432)|mutation decreasing interaction:50-50(MINT-6381428)|mutation decreasing interaction:49-49(MINT-6381430)	binding-associated region:?-?(MINT-6381423)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706750|mint:MINT-6381465|imex:IM-11533-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6381467(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6381471(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F4 T2|comment:"KA(affinity constant)= 0.51 x 10^8/M  The IGF2R-Dom10 13, IGF2R-Dom11 13 and IGF2R-Dom11 14 fragments were coupled directly to a biosensor surface via amine groups to give a final resonance value of 2000 U."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:4E46304608DE5CBE|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	mutation decreasing interaction:48-48(MINT-6381468)	binding-associated region:?-?(MINT-6381472)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706849|mint:MINT-6381591|imex:IM-11533-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6381593(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6381595(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F5 T2|comment:"KA(affinity constant)= 142 x 10^8/M  Surface plasmon resonance to measure binding affinities was conducted by passing a serial dilution of IGF-II (32 2 nM) over biotinylated IGF2R fragments immobilised to streptavidin-coated sensor chips (Rmax of approx100 RU)."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:20A149A5CB540D2D|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	-	binding-associated region:?-?(MINT-6381596)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706890|mint:MINT-6381777|imex:IM-11533-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6381784(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6381779(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F5 T2|comment:"KA(affinity constant)= 14.3 x 10^8/M  Surface plasmon resonance to measure binding affinities was conducted by passing a serial dilution of IGF-II (32 2 nM) over biotinylated IGF2R fragments immobilised to streptavidin-coated sensor chips (Rmax of approx100 RU)."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:2503467910FDCF30|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	-	mutation decreasing interaction:1901-1942(MINT-6381789)|binding-associated region:?-?(MINT-6381780)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706944|mint:MINT-6381798|imex:IM-11533-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6381800(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6381802(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F5 T2|comment:"KA(affinity constant)= 56.1 x 10^8/M  Surface plasmon resonance to measure binding affinities was conducted by passing a serial dilution of IGF-II (32 2 nM) over biotinylated IGF2R fragments immobilised to streptavidin-coated sensor chips (Rmax of approx100 RU)."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:91A02F3ED5AFC10F|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	-	binding-associated region:?-?(MINT-6381805)|mutation decreasing interaction:1901-1942(MINT-6381803)|mutation decreasing interaction:1544-1544(MINT-6381824)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01344	uniprotkb:P11717	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Brown et al. (2008)	pubmed:18046459|imex:IM-11533|mint:MINT-6380932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706995|mint:MINT-6381828|imex:IM-11533-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N|mint:MINT-6381839(identity)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N|mint:MINT-6381830(identity)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:F5 T2|comment:"KA(affinity constant)= 14.9 x 10^8/M  Surface plasmon resonance to measure binding affinities was conducted by passing a serial dilution of IGF-II (32 2 nM) over biotinylated IGF2R fragments immobilised to streptavidin-coated sensor chips (Rmax of approx100 RU)."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:2EC6D2233C40B1A0|rigid:+8PXtUIa/CiI9/wvjBt0llWEbcw	false	-	mutation decreasing interaction:1544-1544(MINT-6381831)|binding-associated region:?-?(MINT-6381833)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)