#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P07332	uniprotkb:P15311	intact:EBI-1055635|uniprotkb:B4DUD0|uniprotkb:E9PC94|uniprotkb:E9PC95|uniprotkb:Q2VXS7|uniprotkb:Q2VXS8|uniprotkb:Q2VXT0|uniprotkb:Q6GTU5|uniprotkb:B2R6E6|ensembl:ENSP00000331504	intact:EBI-1056902|uniprotkb:P23714|uniprotkb:Q4VX75|uniprotkb:Q96CU8|uniprotkb:Q9NSJ4|uniprotkb:E1P5A8|ensembl:ENSP00000338934|ensembl:ENSP00000356042	psi-mi:fes_human(display_long)|uniprotkb:FES(gene name)|psi-mi:FES(display_short)|uniprotkb:FPS(gene name synonym)|uniprotkb:Proto-oncogene c-Fes(gene name synonym)|uniprotkb:Proto-oncogene c-Fps(gene name synonym)|uniprotkb:Feline sarcoma/Fujinami avian sarcoma oncogene homolog(gene name synonym)|uniprotkb:p93c-fes(gene name synonym)	psi-mi:ezri_human(display_long)|uniprotkb:EZR(gene name)|psi-mi:EZR(display_short)|uniprotkb:VIL2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Naba et al. (2008)	pubmed:18046454|imex:IM-11532|mint:MINT-6380309	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7701907|mint:MINT-6380343|imex:IM-11532-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137255.1|refseq:NP_001137256.1|refseq:NP_001137257.1|refseq:NP_001996.1|refseq:XP_005254937.1|refseq:XP_005254939.1|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|mint:P07332|rcsb pdb:1WQU|rcsb pdb:2DCR|rcsb pdb:3BKB|rcsb pdb:3CBL|rcsb pdb:3CD3|rcsb pdb:4DYL|rcsb pdb:4E93|rcsb pdb:6JMF|reactome:R-HSA-1433557|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|ensembl:ENSG00000182511(gene)|ensembl:ENST00000328850(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|refseq:XP_016877494.1|refseq:XP_016877495.1|refseq:XP_016877496.1|refseq:XP_016877497.1|refseq:XP_016877498.1|refseq:XP_016877499.1|mint:MINT-6380347(identity)	ensembl:ENSP00000338934|ensembl:ENSP00000356042|refseq:NP_001104547.1|refseq:NP_003370.2|ensembl:ENSG00000092820(gene)|ensembl:ENST00000337147(transcript)|ensembl:ENST00000367075(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P15311|rcsb pdb:1NI2|rcsb pdb:4RM8|rcsb pdb:4RM9|rcsb pdb:4RMA|reactome:R-HSA-373752|reactome:R-HSA-437239|reactome:R-HSA-9662360|reactome:R-HSA-9662361|dip:DIP-38868N|mint:MINT-6380345(identity)	-	-	-	figure legend:nfa|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/02/20	2014/10/16	rogid:jsI2Ytqu7whZlUt7qISAW3W3WqQ9606	rogid:tSSki5dutR2qqs2dyN3TqcHyiyM9606	intact-crc:94F454D64139CF14|rigid:myZ2c4e8oYhSTfq3talDOOlLbhc	false	tag:?-?(MINT-6380349)|binding-associated region:255-593(MINT-6380352)	tag:?-?(MINT-6380360)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15311	uniprotkb:P07332	intact:EBI-1056902|uniprotkb:P23714|uniprotkb:Q4VX75|uniprotkb:Q96CU8|uniprotkb:Q9NSJ4|uniprotkb:E1P5A8|ensembl:ENSP00000338934|ensembl:ENSP00000356042	intact:EBI-1055635|uniprotkb:B4DUD0|uniprotkb:E9PC94|uniprotkb:E9PC95|uniprotkb:Q2VXS7|uniprotkb:Q2VXS8|uniprotkb:Q2VXT0|uniprotkb:Q6GTU5|uniprotkb:B2R6E6|ensembl:ENSP00000331504	psi-mi:ezri_human(display_long)|uniprotkb:EZR(gene name)|psi-mi:EZR(display_short)|uniprotkb:VIL2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)	psi-mi:fes_human(display_long)|uniprotkb:FES(gene name)|psi-mi:FES(display_short)|uniprotkb:FPS(gene name synonym)|uniprotkb:Proto-oncogene c-Fes(gene name synonym)|uniprotkb:Proto-oncogene c-Fps(gene name synonym)|uniprotkb:Feline sarcoma/Fujinami avian sarcoma oncogene homolog(gene name synonym)|uniprotkb:p93c-fes(gene name synonym)	psi-mi:"MI:0096"(pull down)	Naba et al. (2008)	pubmed:18046454|imex:IM-11532|mint:MINT-6380309	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7701944|mint:MINT-6380367|imex:IM-11532-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000338934|ensembl:ENSP00000356042|refseq:NP_001104547.1|refseq:NP_003370.2|ensembl:ENSG00000092820(gene)|ensembl:ENST00000337147(transcript)|ensembl:ENST00000367075(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P15311|rcsb pdb:1NI2|rcsb pdb:4RM8|rcsb pdb:4RM9|rcsb pdb:4RMA|reactome:R-HSA-373752|reactome:R-HSA-437239|reactome:R-HSA-9662360|reactome:R-HSA-9662361|dip:DIP-38868N|mint:MINT-6380369(identity)	refseq:NP_001137255.1|refseq:NP_001137256.1|refseq:NP_001137257.1|refseq:NP_001996.1|refseq:XP_005254937.1|refseq:XP_005254939.1|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|mint:P07332|rcsb pdb:1WQU|rcsb pdb:2DCR|rcsb pdb:3BKB|rcsb pdb:3CBL|rcsb pdb:3CD3|rcsb pdb:4DYL|rcsb pdb:4E93|rcsb pdb:6JMF|reactome:R-HSA-1433557|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|ensembl:ENSG00000182511(gene)|ensembl:ENST00000328850(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|refseq:XP_016877494.1|refseq:XP_016877495.1|refseq:XP_016877496.1|refseq:XP_016877497.1|refseq:XP_016877498.1|refseq:XP_016877499.1|mint:MINT-6380373(identity)	-	-	-	comment:The interaction is distroyed if cells are stimulated with Src family kinase inhibitors.|figure legend:f1b f1c|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:tSSki5dutR2qqs2dyN3TqcHyiyM9606	rogid:jsI2Ytqu7whZlUt7qISAW3W3WqQ9606	intact-crc:E42B3CA57A7C144E|rigid:myZ2c4e8oYhSTfq3talDOOlLbhc	false	tag:?-?(MINT-6380370)|mutation disrupting interaction:478-478(MINT-6380394)	glutathione s tranferase tag:?-?(MINT-6380377)|binding-associated region:255-593(MINT-6380374)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07332	uniprotkb:P15311	intact:EBI-1055635|uniprotkb:B4DUD0|uniprotkb:E9PC94|uniprotkb:E9PC95|uniprotkb:Q2VXS7|uniprotkb:Q2VXS8|uniprotkb:Q2VXT0|uniprotkb:Q6GTU5|uniprotkb:B2R6E6|ensembl:ENSP00000331504	intact:EBI-1056902|uniprotkb:P23714|uniprotkb:Q4VX75|uniprotkb:Q96CU8|uniprotkb:Q9NSJ4|uniprotkb:E1P5A8|ensembl:ENSP00000338934|ensembl:ENSP00000356042	psi-mi:fes_human(display_long)|uniprotkb:FES(gene name)|psi-mi:FES(display_short)|uniprotkb:FPS(gene name synonym)|uniprotkb:Proto-oncogene c-Fes(gene name synonym)|uniprotkb:Proto-oncogene c-Fps(gene name synonym)|uniprotkb:Feline sarcoma/Fujinami avian sarcoma oncogene homolog(gene name synonym)|uniprotkb:p93c-fes(gene name synonym)	psi-mi:ezri_human(display_long)|uniprotkb:EZR(gene name)|psi-mi:EZR(display_short)|uniprotkb:VIL2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Naba et al. (2008)	pubmed:18046454|imex:IM-11532|mint:MINT-6380309	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7701992|mint:MINT-6380399|imex:IM-11532-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137255.1|refseq:NP_001137256.1|refseq:NP_001137257.1|refseq:NP_001996.1|refseq:XP_005254937.1|refseq:XP_005254939.1|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|mint:P07332|rcsb pdb:1WQU|rcsb pdb:2DCR|rcsb pdb:3BKB|rcsb pdb:3CBL|rcsb pdb:3CD3|rcsb pdb:4DYL|rcsb pdb:4E93|rcsb pdb:6JMF|reactome:R-HSA-1433557|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|ensembl:ENSG00000182511(gene)|ensembl:ENST00000328850(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|refseq:XP_016877494.1|refseq:XP_016877495.1|refseq:XP_016877496.1|refseq:XP_016877497.1|refseq:XP_016877498.1|refseq:XP_016877499.1|mint:MINT-6380407(identity)	ensembl:ENSP00000338934|ensembl:ENSP00000356042|refseq:NP_001104547.1|refseq:NP_003370.2|ensembl:ENSG00000092820(gene)|ensembl:ENST00000337147(transcript)|ensembl:ENST00000367075(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P15311|rcsb pdb:1NI2|rcsb pdb:4RM8|rcsb pdb:4RM9|rcsb pdb:4RMA|reactome:R-HSA-373752|reactome:R-HSA-437239|reactome:R-HSA-9662360|reactome:R-HSA-9662361|dip:DIP-38868N|mint:MINT-6380401(identity)	-	-	-	figure legend:f1e|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/20	2014/10/16	rogid:jsI2Ytqu7whZlUt7qISAW3W3WqQ9606	rogid:tSSki5dutR2qqs2dyN3TqcHyiyM9606	intact-crc:B2083907FEE835F4|rigid:myZ2c4e8oYhSTfq3talDOOlLbhc	false	glutathione s tranferase tag:?-?(MINT-6380408)|binding-associated region:255-593(MINT-6380410)	binding-associated region:476-481(MINT-6380418)|phosphorylated residue:478-478(MINT-6380420)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P07332	uniprotkb:P15311	intact:EBI-1055635|uniprotkb:B4DUD0|uniprotkb:E9PC94|uniprotkb:E9PC95|uniprotkb:Q2VXS7|uniprotkb:Q2VXS8|uniprotkb:Q2VXT0|uniprotkb:Q6GTU5|uniprotkb:B2R6E6|ensembl:ENSP00000331504	intact:EBI-1056902|uniprotkb:P23714|uniprotkb:Q4VX75|uniprotkb:Q96CU8|uniprotkb:Q9NSJ4|uniprotkb:E1P5A8|ensembl:ENSP00000338934|ensembl:ENSP00000356042	psi-mi:fes_human(display_long)|uniprotkb:FES(gene name)|psi-mi:FES(display_short)|uniprotkb:FPS(gene name synonym)|uniprotkb:Proto-oncogene c-Fes(gene name synonym)|uniprotkb:Proto-oncogene c-Fps(gene name synonym)|uniprotkb:Feline sarcoma/Fujinami avian sarcoma oncogene homolog(gene name synonym)|uniprotkb:p93c-fes(gene name synonym)	psi-mi:ezri_human(display_long)|uniprotkb:EZR(gene name)|psi-mi:EZR(display_short)|uniprotkb:VIL2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Naba et al. (2008)	pubmed:18046454|imex:IM-11532|mint:MINT-6380309	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7702035|mint:MINT-6380786|imex:IM-11532-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137255.1|refseq:NP_001137256.1|refseq:NP_001137257.1|refseq:NP_001996.1|refseq:XP_005254937.1|refseq:XP_005254939.1|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|mint:P07332|rcsb pdb:1WQU|rcsb pdb:2DCR|rcsb pdb:3BKB|rcsb pdb:3CBL|rcsb pdb:3CD3|rcsb pdb:4DYL|rcsb pdb:4E93|rcsb pdb:6JMF|reactome:R-HSA-1433557|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|ensembl:ENSG00000182511(gene)|ensembl:ENST00000328850(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|refseq:XP_016877494.1|refseq:XP_016877495.1|refseq:XP_016877496.1|refseq:XP_016877497.1|refseq:XP_016877498.1|refseq:XP_016877499.1|mint:MINT-6380792(identity)	ensembl:ENSP00000338934|ensembl:ENSP00000356042|refseq:NP_001104547.1|refseq:NP_003370.2|ensembl:ENSG00000092820(gene)|ensembl:ENST00000337147(transcript)|ensembl:ENST00000367075(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P15311|rcsb pdb:1NI2|rcsb pdb:4RM8|rcsb pdb:4RM9|rcsb pdb:4RMA|reactome:R-HSA-373752|reactome:R-HSA-437239|reactome:R-HSA-9662360|reactome:R-HSA-9662361|dip:DIP-38868N|mint:MINT-6380788(identity)	go:"GO:0016328"(lateral plasma membrane)	-	-	figure legend:f2c|comment:Fes and ezrin human protein IDs have been used instead of sus scrofa IDs.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9823(pig-ln_229)|taxid:9823(Sus scrofa)	-	2008/02/20	2014/10/16	rogid:jsI2Ytqu7whZlUt7qISAW3W3WqQ9606	rogid:tSSki5dutR2qqs2dyN3TqcHyiyM9606	intact-crc:8006495CBB836C9F|rigid:myZ2c4e8oYhSTfq3talDOOlLbhc	false	phosphorylated residue:713-713(MINT-6380793)	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:O18922	uniprotkb:P07332	intact:EBI-7702062|intact:MINT-6380839	intact:EBI-1055635|uniprotkb:B4DUD0|uniprotkb:E9PC94|uniprotkb:E9PC95|uniprotkb:Q2VXS7|uniprotkb:Q2VXS8|uniprotkb:Q2VXT0|uniprotkb:Q6GTU5|uniprotkb:B2R6E6|ensembl:ENSP00000331504	psi-mi:o18922_pig(display_long)	psi-mi:fes_human(display_long)|uniprotkb:FES(gene name)|psi-mi:FES(display_short)|uniprotkb:FPS(gene name synonym)|uniprotkb:Proto-oncogene c-Fes(gene name synonym)|uniprotkb:Proto-oncogene c-Fps(gene name synonym)|uniprotkb:Feline sarcoma/Fujinami avian sarcoma oncogene homolog(gene name synonym)|uniprotkb:p93c-fes(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Naba et al. (2008)	pubmed:18046454|imex:IM-11532|mint:MINT-6380309	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7702055|mint:MINT-6380827|imex:IM-11532-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O18922|go:"GO:0005509"(calcium ion binding)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR027397|interpro:IPR039808|mint:MINT-6380830(identity)	refseq:NP_001137255.1|refseq:NP_001137256.1|refseq:NP_001137257.1|refseq:NP_001996.1|refseq:XP_005254937.1|refseq:XP_005254939.1|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|mint:P07332|rcsb pdb:1WQU|rcsb pdb:2DCR|rcsb pdb:3BKB|rcsb pdb:3CBL|rcsb pdb:3CD3|rcsb pdb:4DYL|rcsb pdb:4E93|rcsb pdb:6JMF|reactome:R-HSA-1433557|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|ensembl:ENSG00000182511(gene)|ensembl:ENST00000328850(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|refseq:XP_016877494.1|refseq:XP_016877495.1|refseq:XP_016877496.1|refseq:XP_016877497.1|refseq:XP_016877498.1|refseq:XP_016877499.1|mint:MINT-6380832(identity)	go:"GO:0016328"(lateral plasma membrane)	comment:"fragmentation type: fragment"|comment:mint	-	figure legend:f2c|comment:Fes human protein IDs has been used instead of sus scrofa IDs.|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9823(pig-ln_229)|taxid:9823(Sus scrofa)	-	2008/02/20	2014/10/16	rogid:Lossclqybhl1z2gcfTqPy/GW1Sk9823	rogid:jsI2Ytqu7whZlUt7qISAW3W3WqQ9606	intact-crc:B2839C799C422DBD|rigid:bqXsX5tnPPdZ1RHELsi+GVu0XQk	false	-	phosphorylated residue:713-713(MINT-6380833)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P07332	uniprotkb:P15311	intact:EBI-1055635|uniprotkb:B4DUD0|uniprotkb:E9PC94|uniprotkb:E9PC95|uniprotkb:Q2VXS7|uniprotkb:Q2VXS8|uniprotkb:Q2VXT0|uniprotkb:Q6GTU5|uniprotkb:B2R6E6|ensembl:ENSP00000331504	intact:EBI-1056902|uniprotkb:P23714|uniprotkb:Q4VX75|uniprotkb:Q96CU8|uniprotkb:Q9NSJ4|uniprotkb:E1P5A8|ensembl:ENSP00000338934|ensembl:ENSP00000356042	psi-mi:fes_human(display_long)|uniprotkb:FES(gene name)|psi-mi:FES(display_short)|uniprotkb:FPS(gene name synonym)|uniprotkb:Proto-oncogene c-Fes(gene name synonym)|uniprotkb:Proto-oncogene c-Fps(gene name synonym)|uniprotkb:Feline sarcoma/Fujinami avian sarcoma oncogene homolog(gene name synonym)|uniprotkb:p93c-fes(gene name synonym)	psi-mi:ezri_human(display_long)|uniprotkb:EZR(gene name)|psi-mi:EZR(display_short)|uniprotkb:VIL2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Naba et al. (2008)	pubmed:18046454|imex:IM-11532|mint:MINT-6380309	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7702182|mint:MINT-6380517|imex:IM-11532-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137255.1|refseq:NP_001137256.1|refseq:NP_001137257.1|refseq:NP_001996.1|refseq:XP_005254937.1|refseq:XP_005254939.1|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|mint:P07332|rcsb pdb:1WQU|rcsb pdb:2DCR|rcsb pdb:3BKB|rcsb pdb:3CBL|rcsb pdb:3CD3|rcsb pdb:4DYL|rcsb pdb:4E93|rcsb pdb:6JMF|reactome:R-HSA-1433557|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|ensembl:ENSG00000182511(gene)|ensembl:ENST00000328850(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|refseq:XP_016877494.1|refseq:XP_016877495.1|refseq:XP_016877496.1|refseq:XP_016877497.1|refseq:XP_016877498.1|refseq:XP_016877499.1|mint:MINT-6380525(identity)	ensembl:ENSP00000338934|ensembl:ENSP00000356042|refseq:NP_001104547.1|refseq:NP_003370.2|ensembl:ENSG00000092820(gene)|ensembl:ENST00000337147(transcript)|ensembl:ENST00000367075(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P15311|rcsb pdb:1NI2|rcsb pdb:4RM8|rcsb pdb:4RM9|rcsb pdb:4RMA|reactome:R-HSA-373752|reactome:R-HSA-437239|reactome:R-HSA-9662360|reactome:R-HSA-9662361|dip:DIP-38868N|mint:MINT-6380519(identity)	-	-	-	figure legend:f2d|comment:Fes and ezrin human protein IDs have been used instead of sus scrofa IDs.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9823(pig-ln_229)|taxid:9823(Sus scrofa)	-	2008/02/20	2014/10/16	rogid:jsI2Ytqu7whZlUt7qISAW3W3WqQ9606	rogid:tSSki5dutR2qqs2dyN3TqcHyiyM9606	intact-crc:69E66B932D641FF7|rigid:myZ2c4e8oYhSTfq3talDOOlLbhc	false	phosphorylated residue:713-713(MINT-6380573)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P07332	uniprotkb:P15311	intact:EBI-1055635|uniprotkb:B4DUD0|uniprotkb:E9PC94|uniprotkb:E9PC95|uniprotkb:Q2VXS7|uniprotkb:Q2VXS8|uniprotkb:Q2VXT0|uniprotkb:Q6GTU5|uniprotkb:B2R6E6|ensembl:ENSP00000331504	intact:EBI-1056902|uniprotkb:P23714|uniprotkb:Q4VX75|uniprotkb:Q96CU8|uniprotkb:Q9NSJ4|uniprotkb:E1P5A8|ensembl:ENSP00000338934|ensembl:ENSP00000356042	psi-mi:fes_human(display_long)|uniprotkb:FES(gene name)|psi-mi:FES(display_short)|uniprotkb:FPS(gene name synonym)|uniprotkb:Proto-oncogene c-Fes(gene name synonym)|uniprotkb:Proto-oncogene c-Fps(gene name synonym)|uniprotkb:Feline sarcoma/Fujinami avian sarcoma oncogene homolog(gene name synonym)|uniprotkb:p93c-fes(gene name synonym)	psi-mi:ezri_human(display_long)|uniprotkb:EZR(gene name)|psi-mi:EZR(display_short)|uniprotkb:VIL2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Naba et al. (2008)	pubmed:18046454|imex:IM-11532|mint:MINT-6380309	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7702239|mint:MINT-6380771|imex:IM-11532-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137255.1|refseq:NP_001137256.1|refseq:NP_001137257.1|refseq:NP_001996.1|refseq:XP_005254937.1|refseq:XP_005254939.1|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|mint:P07332|rcsb pdb:1WQU|rcsb pdb:2DCR|rcsb pdb:3BKB|rcsb pdb:3CBL|rcsb pdb:3CD3|rcsb pdb:4DYL|rcsb pdb:4E93|rcsb pdb:6JMF|reactome:R-HSA-1433557|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|ensembl:ENSG00000182511(gene)|ensembl:ENST00000328850(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|refseq:XP_016877494.1|refseq:XP_016877495.1|refseq:XP_016877496.1|refseq:XP_016877497.1|refseq:XP_016877498.1|refseq:XP_016877499.1|mint:MINT-6380773(identity)	ensembl:ENSP00000338934|ensembl:ENSP00000356042|refseq:NP_001104547.1|refseq:NP_003370.2|ensembl:ENSG00000092820(gene)|ensembl:ENST00000337147(transcript)|ensembl:ENST00000367075(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P15311|rcsb pdb:1NI2|rcsb pdb:4RM8|rcsb pdb:4RM9|rcsb pdb:4RMA|reactome:R-HSA-373752|reactome:R-HSA-437239|reactome:R-HSA-9662360|reactome:R-HSA-9662361|dip:DIP-38868N|mint:MINT-6380777(identity)	-	-	-	figure legend:f3b|comment:Fes human protein ID has been used instead of sus scrofa ID.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9823(pig-ln_229)|taxid:9823(Sus scrofa)	-	2008/02/20	2014/10/16	rogid:jsI2Ytqu7whZlUt7qISAW3W3WqQ9606	rogid:tSSki5dutR2qqs2dyN3TqcHyiyM9606	intact-crc:5874A4BBC41E8BD1|rigid:myZ2c4e8oYhSTfq3talDOOlLbhc	false	phosphorylated residue:713-713(MINT-6380774)	tag:?-?(MINT-6380782)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P07332	uniprotkb:P15311	intact:EBI-1055635|uniprotkb:B4DUD0|uniprotkb:E9PC94|uniprotkb:E9PC95|uniprotkb:Q2VXS7|uniprotkb:Q2VXS8|uniprotkb:Q2VXT0|uniprotkb:Q6GTU5|uniprotkb:B2R6E6|ensembl:ENSP00000331504	intact:EBI-1056902|uniprotkb:P23714|uniprotkb:Q4VX75|uniprotkb:Q96CU8|uniprotkb:Q9NSJ4|uniprotkb:E1P5A8|ensembl:ENSP00000338934|ensembl:ENSP00000356042	psi-mi:fes_human(display_long)|uniprotkb:FES(gene name)|psi-mi:FES(display_short)|uniprotkb:FPS(gene name synonym)|uniprotkb:Proto-oncogene c-Fes(gene name synonym)|uniprotkb:Proto-oncogene c-Fps(gene name synonym)|uniprotkb:Feline sarcoma/Fujinami avian sarcoma oncogene homolog(gene name synonym)|uniprotkb:p93c-fes(gene name synonym)	psi-mi:ezri_human(display_long)|uniprotkb:EZR(gene name)|psi-mi:EZR(display_short)|uniprotkb:VIL2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Naba et al. (2008)	pubmed:18046454|imex:IM-11532|mint:MINT-6380309	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7702272|mint:MINT-8035482|imex:IM-11532-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137255.1|refseq:NP_001137256.1|refseq:NP_001137257.1|refseq:NP_001996.1|refseq:XP_005254937.1|refseq:XP_005254939.1|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|mint:P07332|rcsb pdb:1WQU|rcsb pdb:2DCR|rcsb pdb:3BKB|rcsb pdb:3CBL|rcsb pdb:3CD3|rcsb pdb:4DYL|rcsb pdb:4E93|rcsb pdb:6JMF|reactome:R-HSA-1433557|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|ensembl:ENSG00000182511(gene)|ensembl:ENST00000328850(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|refseq:XP_016877494.1|refseq:XP_016877495.1|refseq:XP_016877496.1|refseq:XP_016877497.1|refseq:XP_016877498.1|refseq:XP_016877499.1|mint:MINT-8035483(identity)|uniprotkb:P07332(original identifier)	ensembl:ENSP00000338934|ensembl:ENSP00000356042|refseq:NP_001104547.1|refseq:NP_003370.2|ensembl:ENSG00000092820(gene)|ensembl:ENST00000337147(transcript)|ensembl:ENST00000367075(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P15311|rcsb pdb:1NI2|rcsb pdb:4RM8|rcsb pdb:4RM9|rcsb pdb:4RMA|reactome:R-HSA-373752|reactome:R-HSA-437239|reactome:R-HSA-9662360|reactome:R-HSA-9662361|dip:DIP-38868N|mint:MINT-8035486(identity)|uniprotkb:P15311(original identifier)	-	-	-	comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/02/20	2014/10/16	rogid:jsI2Ytqu7whZlUt7qISAW3W3WqQ9606	rogid:tSSki5dutR2qqs2dyN3TqcHyiyM9606	intact-crc:FCC90676BE7C905C|rigid:myZ2c4e8oYhSTfq3talDOOlLbhc	false	-	phosphorylated residue:478-478(MINT-8035491)|binding-associated region:471-484(MINT-8035489)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07332	uniprotkb:P15311	intact:EBI-1055635|uniprotkb:B4DUD0|uniprotkb:E9PC94|uniprotkb:E9PC95|uniprotkb:Q2VXS7|uniprotkb:Q2VXS8|uniprotkb:Q2VXT0|uniprotkb:Q6GTU5|uniprotkb:B2R6E6|ensembl:ENSP00000331504	intact:EBI-1056902|uniprotkb:P23714|uniprotkb:Q4VX75|uniprotkb:Q96CU8|uniprotkb:Q9NSJ4|uniprotkb:E1P5A8|ensembl:ENSP00000338934|ensembl:ENSP00000356042	psi-mi:fes_human(display_long)|uniprotkb:FES(gene name)|psi-mi:FES(display_short)|uniprotkb:FPS(gene name synonym)|uniprotkb:Proto-oncogene c-Fes(gene name synonym)|uniprotkb:Proto-oncogene c-Fps(gene name synonym)|uniprotkb:Feline sarcoma/Fujinami avian sarcoma oncogene homolog(gene name synonym)|uniprotkb:p93c-fes(gene name synonym)	psi-mi:ezri_human(display_long)|uniprotkb:EZR(gene name)|psi-mi:EZR(display_short)|uniprotkb:VIL2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Naba et al. (2008)	pubmed:18046454|imex:IM-11532|mint:MINT-6380309	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7702301|mint:MINT-8035497|imex:IM-11532-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137255.1|refseq:NP_001137256.1|refseq:NP_001137257.1|refseq:NP_001996.1|refseq:XP_005254937.1|refseq:XP_005254939.1|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|mint:P07332|rcsb pdb:1WQU|rcsb pdb:2DCR|rcsb pdb:3BKB|rcsb pdb:3CBL|rcsb pdb:3CD3|rcsb pdb:4DYL|rcsb pdb:4E93|rcsb pdb:6JMF|reactome:R-HSA-1433557|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|ensembl:ENSG00000182511(gene)|ensembl:ENST00000328850(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|refseq:XP_016877494.1|refseq:XP_016877495.1|refseq:XP_016877496.1|refseq:XP_016877497.1|refseq:XP_016877498.1|refseq:XP_016877499.1|mint:MINT-8035498(identity)|uniprotkb:P07332(original identifier)	ensembl:ENSP00000338934|ensembl:ENSP00000356042|refseq:NP_001104547.1|refseq:NP_003370.2|ensembl:ENSG00000092820(gene)|ensembl:ENST00000337147(transcript)|ensembl:ENST00000367075(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P15311|rcsb pdb:1NI2|rcsb pdb:4RM8|rcsb pdb:4RM9|rcsb pdb:4RMA|reactome:R-HSA-373752|reactome:R-HSA-437239|reactome:R-HSA-9662360|reactome:R-HSA-9662361|dip:DIP-38868N|mint:MINT-8035501(identity)|uniprotkb:P15311(original identifier)	-	-	-	comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/02/20	2014/10/16	rogid:jsI2Ytqu7whZlUt7qISAW3W3WqQ9606	rogid:tSSki5dutR2qqs2dyN3TqcHyiyM9606	intact-crc:CFD89CD0FAB1B9A3|rigid:myZ2c4e8oYhSTfq3talDOOlLbhc	false	-	binding-associated region:471-484(MINT-8035504)|phosphorylated residue:478-478(MINT-8035506)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)