#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P40337-3	uniprotkb:Q96KS0	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-726614|uniprotkb:Q8WWY4|uniprotkb:Q9BV14|ensembl:ENSP00000307080|ensembl:ENSP00000385253|ensembl:ENSP00000469686|uniprotkb:A8K5S0	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:egln2_human(display_long)|uniprotkb:Hypoxia-inducible factor prolyl hydroxylase 1(gene name synonym)|uniprotkb:HPH-3(gene name synonym)|uniprotkb:Prolyl hydroxylase domain-containing protein 1(gene name synonym)|uniprotkb:Estrogen-induced tag 6(gene name synonym)|uniprotkb:EGLN2(gene name)|psi-mi:EGLN2(display_short)|uniprotkb:EIT6(gene name synonym)|uniprotkb:Egl nine homolog 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765250	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|mint:Q96KS0|rcsb pdb:5V1B|reactome:R-HSA-1234176|ensembl:ENSG00000269858(gene)|ensembl:ENST00000303961(transcript)|ensembl:ENST00000406058(transcript)|ensembl:ENST00000593726(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|refseq:NP_444274.1|refseq:NP_542770.2	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:2 A, 4|comment:"This interaction was absolutely dependent on the presence of one of the three prolylhydroxylases (PHDs) (PHD1-3)."|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:THkV+JMTOIr/RnMXla7QAPAL7ow9606	intact-crc:18073CD8DB0F1013|rigid:e3U1YdPY+mpN3rsPhn13VYGK52E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40337-3	uniprotkb:Q16665	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765250	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:2 A, 4|comment:"This interaction was absolutely dependent on the presence of one of the three prolylhydroxylases (PHDs) (PHD1-3)."|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	intact-crc:18073CD8DB0F1013|rigid:e3U1YdPY+mpN3rsPhn13VYGK52E	false	-	mutation disrupting interaction:402-402,564-564|dihydroxylated residue:402-402|dihydroxylated residue:564-564	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40337-3	uniprotkb:O75912	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1765520|uniprotkb:Q9NZ49|uniprotkb:A4D1Q9|intact:EBI-28976042|ensembl:ENSP00000288490	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:dgki_human(display_long)|uniprotkb:DGKI(gene name)|psi-mi:DGKI(display_short)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765779	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	refseq:NP_004708.1|ensembl:ENSP00000288490|refseq:NP_001308637.1|refseq:NP_001308638.1|refseq:NP_001308639.1|ensembl:ENSG00000157680(gene)|ensembl:ENST00000288490(transcript)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0004143"(diacylglycerol kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030168"(platelet activation)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046834"(lipid phosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097060"(synaptic membrane)|interpro:IPR000756(Diacylglycerol kinase accessory region)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR002110(Ankyrin)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037607|reactome:R-HSA-114508	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:4 A, B, 5|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3. There was only a weak interaction in the presence of PHD1 or PHD2.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:ht89r7Xcvhg9W3KgyvPl3gjkHz09606	intact-crc:DCFA4D689972FE0B|rigid:albnWWq9A4/T2XYndcCYdvtsEso	false	-	sufficient binding region:879-1065|mutation disrupting interaction:903-903|mutation disrupting interaction:147-147,903-903	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40337-3	uniprotkb:Q9GZT9	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1174818|uniprotkb:Q8N3M8|uniprotkb:Q9BZS8|uniprotkb:Q9BZT0|ensembl:ENSP00000355601	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:egln1_human(display_long)|uniprotkb:EGLN1(gene name)|psi-mi:EGLN1(display_short)|uniprotkb:C1orf12(gene name synonym)|uniprotkb:PNAS-118(orf name)|uniprotkb:PNAS-137(orf name)|uniprotkb:Hypoxia-inducible factor prolyl hydroxylase 2(gene name synonym)|uniprotkb:Prolyl hydroxylase domain-containing protein 2(gene name synonym)|uniprotkb:SM-20(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1791353	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	refseq:NP_071334.1|ensembl:ENSG00000135766(gene)|ensembl:ENST00000366641(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071731"(response to nitric oxide)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|mint:Q9GZT9|rcsb pdb:2G19|rcsb pdb:2G1M|rcsb pdb:2HBT|rcsb pdb:2HBU|rcsb pdb:2Y33|rcsb pdb:2Y34|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:3OUH|rcsb pdb:3OUI|rcsb pdb:3OUJ|rcsb pdb:4BQW|rcsb pdb:4BQX|rcsb pdb:4BQY|rcsb pdb:4JZR|rcsb pdb:4KBZ|rcsb pdb:4UWD|rcsb pdb:5A3U|rcsb pdb:5L9B|rcsb pdb:5L9R|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:5LAT|rcsb pdb:5LB6|rcsb pdb:5LBB|rcsb pdb:5LBC|rcsb pdb:5LBE|rcsb pdb:5LBF|rcsb pdb:5OX5|rcsb pdb:5OX6|rcsb pdb:5V18|rcsb pdb:6NMQ|rcsb pdb:6QGV|rcsb pdb:6ST3|rcsb pdb:6YVT|rcsb pdb:6YVW|rcsb pdb:6YVX|rcsb pdb:6YVZ|rcsb pdb:6YW0|rcsb pdb:6YW1|rcsb pdb:6YW2|rcsb pdb:6YW3|rcsb pdb:6YW4|rcsb pdb:6ZBN|rcsb pdb:6ZBO|reactome:R-HSA-1234176|dip:DIP-37495N	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:2 A, 4|comment:"This interaction was absolutely dependent on the presence of one of the three prolylhydroxylases (PHDS) (PHD1-3)."|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:mQuU/7x78A4wIxQZxk2Pldj+94s9606	intact-crc:7F8251A694529D6C|rigid:S3bSEP/HMaIqnW8/f7uoxNBOAEE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40337-3	uniprotkb:Q16665	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1791353	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:2 A, 4|comment:"This interaction was absolutely dependent on the presence of one of the three prolylhydroxylases (PHDS) (PHD1-3)."|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	intact-crc:7F8251A694529D6C|rigid:S3bSEP/HMaIqnW8/f7uoxNBOAEE	false	-	mutation disrupting interaction:402-402,564-564	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40337-3	uniprotkb:Q16665	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1791388	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:2 A, 4|comment:"This interaction was absolutely dependent on the presence of one of the three prolylhydroxylases (PHDS) (PHD1-3)."|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	intact-crc:F007D123B8746555|rigid:2MvB02fyRCcyzmkhzPnvaysNQKg	false	-	mutation disrupting interaction:402-402,564-564	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40337-3	uniprotkb:Q9H6Z9	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1175354|uniprotkb:Q2TA79|uniprotkb:Q3B8N4|uniprotkb:Q6P1R2|ensembl:ENSP00000250457	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:egln3_human(display_long)|uniprotkb:Hypoxia-inducible factor prolyl hydroxylase 3(gene name synonym)|uniprotkb:HPH-1(gene name synonym)|uniprotkb:Prolyl hydroxylase domain-containing protein 3(gene name synonym)|uniprotkb:EGLN3(gene name)|psi-mi:EGLN3(display_short)|uniprotkb:Egl nine homolog 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1791388	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0018126"(protein hydroxylation)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|mint:Q9H6Z9|reactome:R-HSA-1234176|ensembl:ENSG00000129521(gene)|ensembl:ENST00000250457(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_071356.1|refseq:NP_001295032.1	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:2 A, 4|comment:"This interaction was absolutely dependent on the presence of one of the three prolylhydroxylases (PHDS) (PHD1-3)."|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:qkcZeQzvxL+8efCa0kakLjwXDt89606	intact-crc:F007D123B8746555|rigid:2MvB02fyRCcyzmkhzPnvaysNQKg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40337-3	uniprotkb:Q15369	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765376	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was not dependent upon the presence of a prolylhydroxylase.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606	intact-crc:AF416D1B2A4124E3|rigid:+YsHGtS2kCYhvFxVEE1hvzcv2bM	false	-	sufficient binding region:4-112	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q15370	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765386	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was not dependent upon the presence of a prolylhydroxylase.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606	intact-crc:3A9F8B8F476FD31F|rigid:yZ6iHkvXtkLcLqx5qxwTaUgiZBQ	false	-	sufficient binding region:2-118	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q9H6Z9	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1175354|uniprotkb:Q2TA79|uniprotkb:Q3B8N4|uniprotkb:Q6P1R2|ensembl:ENSP00000250457	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:egln3_human(display_long)|uniprotkb:Hypoxia-inducible factor prolyl hydroxylase 3(gene name synonym)|uniprotkb:HPH-1(gene name synonym)|uniprotkb:Prolyl hydroxylase domain-containing protein 3(gene name synonym)|uniprotkb:EGLN3(gene name)|psi-mi:EGLN3(display_short)|uniprotkb:Egl nine homolog 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765410	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0018126"(protein hydroxylation)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|mint:Q9H6Z9|reactome:R-HSA-1234176|ensembl:ENSG00000129521(gene)|ensembl:ENST00000250457(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_071356.1|refseq:NP_001295032.1	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:qkcZeQzvxL+8efCa0kakLjwXDt89606	intact-crc:AAE8107D05287673|rigid:2MvB02fyRCcyzmkhzPnvaysNQKg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q16665	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765410	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	intact-crc:AAE8107D05287673|rigid:2MvB02fyRCcyzmkhzPnvaysNQKg	false	-	dihydroxylated residue:402-402|sufficient binding region:564-564|sufficient binding region:232-439|sufficient binding region:537-777	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q9H6Z9	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1175354|uniprotkb:Q2TA79|uniprotkb:Q3B8N4|uniprotkb:Q6P1R2|ensembl:ENSP00000250457	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:egln3_human(display_long)|uniprotkb:Hypoxia-inducible factor prolyl hydroxylase 3(gene name synonym)|uniprotkb:HPH-1(gene name synonym)|uniprotkb:Prolyl hydroxylase domain-containing protein 3(gene name synonym)|uniprotkb:EGLN3(gene name)|psi-mi:EGLN3(display_short)|uniprotkb:Egl nine homolog 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765482	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0018126"(protein hydroxylation)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|mint:Q9H6Z9|reactome:R-HSA-1234176|ensembl:ENSG00000129521(gene)|ensembl:ENST00000250457(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_071356.1|refseq:NP_001295032.1	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:qkcZeQzvxL+8efCa0kakLjwXDt89606	intact-crc:E057618D806AB48A|rigid:U0Kqf+c3FrDM73uayCMY3ut5Sr8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q99814	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-447470|uniprotkb:Q86VA2|uniprotkb:Q99630|ensembl:ENSP00000263734	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:epas1_human(display_long)|uniprotkb:EPAS1(gene name)|psi-mi:EPAS1(display_short)|uniprotkb:HIF2A(gene name synonym)|uniprotkb:MOP2(gene name synonym)|uniprotkb:Member of PAS protein 2(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP2(gene name synonym)|uniprotkb:BHLHE73(gene name synonym)|uniprotkb:PASD2(gene name synonym)|uniprotkb:Hypoxia-inducible factor 2-alpha(gene name synonym)|uniprotkb:HIF-1-alpha-like factor(gene name synonym)|uniprotkb:PAS domain-containing protein 2(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 73(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765482	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	refseq:NP_001421.2|dip:DIP-32857N|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2000434"(regulation of protein neddylation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q99814|rcsb pdb:1P97|rcsb pdb:2A24|rcsb pdb:3F1N|rcsb pdb:3F1O|rcsb pdb:3F1P|rcsb pdb:3H7W|rcsb pdb:3H82|rcsb pdb:4GHI|rcsb pdb:4GS9|rcsb pdb:4PKY|rcsb pdb:4XT2|rcsb pdb:5KIZ|rcsb pdb:5TBM|rcsb pdb:5UFP|rcsb pdb:6BVB|rcsb pdb:6CZW|rcsb pdb:6D09|rcsb pdb:6D0B|rcsb pdb:6D0C|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6X21|rcsb pdb:6X28|rcsb pdb:6X2H|rcsb pdb:6X37|rcsb pdb:6X3D|reactome:R-HSA-1234158|reactome:R-HSA-1234174|go:"GO:0048469"(cell maturation)|reactome:R-HSA-1234176|reactome:R-HSA-452723|reactome:R-HSA-8849473|reactome:R-HSA-8951664|reactome:R-HSA-9664873|ensembl:ENSG00000116016(gene)|ensembl:ENST00000263734(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:rBmVytqL/OrXjDJxbgvsa8r98DI9606	intact-crc:E057618D806AB48A|rigid:U0Kqf+c3FrDM73uayCMY3ut5Sr8	false	-	sufficient binding region:331-537	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q9H6Z9	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1175354|uniprotkb:Q2TA79|uniprotkb:Q3B8N4|uniprotkb:Q6P1R2|ensembl:ENSP00000250457	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:egln3_human(display_long)|uniprotkb:Hypoxia-inducible factor prolyl hydroxylase 3(gene name synonym)|uniprotkb:HPH-1(gene name synonym)|uniprotkb:Prolyl hydroxylase domain-containing protein 3(gene name synonym)|uniprotkb:EGLN3(gene name)|psi-mi:EGLN3(display_short)|uniprotkb:Egl nine homolog 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765539	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0018126"(protein hydroxylation)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|mint:Q9H6Z9|reactome:R-HSA-1234176|ensembl:ENSG00000129521(gene)|ensembl:ENST00000250457(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_071356.1|refseq:NP_001295032.1	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:qkcZeQzvxL+8efCa0kakLjwXDt89606	intact-crc:B73068B4213B889C|rigid:fPzokVDVKX6Se7lkym8J19HkvI8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:O75912	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1765520|uniprotkb:Q9NZ49|uniprotkb:A4D1Q9|intact:EBI-28976042|ensembl:ENSP00000288490	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:dgki_human(display_long)|uniprotkb:DGKI(gene name)|psi-mi:DGKI(display_short)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765539	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	refseq:NP_004708.1|ensembl:ENSP00000288490|refseq:NP_001308637.1|refseq:NP_001308638.1|refseq:NP_001308639.1|ensembl:ENSG00000157680(gene)|ensembl:ENST00000288490(transcript)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0004143"(diacylglycerol kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030168"(platelet activation)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046834"(lipid phosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097060"(synaptic membrane)|interpro:IPR000756(Diacylglycerol kinase accessory region)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR002110(Ankyrin)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037607|reactome:R-HSA-114508	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:ht89r7Xcvhg9W3KgyvPl3gjkHz09606	intact-crc:B73068B4213B889C|rigid:fPzokVDVKX6Se7lkym8J19HkvI8	false	-	sufficient binding region:668-910	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q9H6Z9	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1175354|uniprotkb:Q2TA79|uniprotkb:Q3B8N4|uniprotkb:Q6P1R2|ensembl:ENSP00000250457	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:egln3_human(display_long)|uniprotkb:Hypoxia-inducible factor prolyl hydroxylase 3(gene name synonym)|uniprotkb:HPH-1(gene name synonym)|uniprotkb:Prolyl hydroxylase domain-containing protein 3(gene name synonym)|uniprotkb:EGLN3(gene name)|psi-mi:EGLN3(display_short)|uniprotkb:Egl nine homolog 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765581	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0018126"(protein hydroxylation)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|mint:Q9H6Z9|reactome:R-HSA-1234176|ensembl:ENSG00000129521(gene)|ensembl:ENST00000250457(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_071356.1|refseq:NP_001295032.1	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:qkcZeQzvxL+8efCa0kakLjwXDt89606	intact-crc:8B11625AAF25DD04|rigid:vWhKl2xPaNvHQKokK7iMFxs3xcw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q99661	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1642317|uniprotkb:Q96C18|uniprotkb:Q96HB8|uniprotkb:Q9BWV8|uniprotkb:Q5JR88|uniprotkb:B3ITR9|uniprotkb:Q6ICU1|ensembl:ENSP00000361298	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:kif2c_human(display_long)|uniprotkb:KNSL6(gene name synonym)|uniprotkb:KIF2C(gene name)|psi-mi:KIF2C(display_short)|uniprotkb:Mitotic centromere-associated kinesin(gene name synonym)|uniprotkb:Kinesin-like protein 6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765581	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	refseq:NP_006836.2|refseq:NP_001284584.1|refseq:NP_001284585.1|refseq:NP_001284586.1|ensembl:ENSG00000142945(gene)|ensembl:ENST00000372224(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q99661|rcsb pdb:2HEH|rcsb pdb:4UBF|rcsb pdb:4Y05|rcsb pdb:5MIO|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-6811434|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983189	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:XKQr6i+9Xtdfir6V1C8PByAIg1c9606	intact-crc:8B11625AAF25DD04|rigid:vWhKl2xPaNvHQKokK7iMFxs3xcw	false	-	sufficient binding region:558-681	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q9H6Z9	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1175354|uniprotkb:Q2TA79|uniprotkb:Q3B8N4|uniprotkb:Q6P1R2|ensembl:ENSP00000250457	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:egln3_human(display_long)|uniprotkb:Hypoxia-inducible factor prolyl hydroxylase 3(gene name synonym)|uniprotkb:HPH-1(gene name synonym)|uniprotkb:Prolyl hydroxylase domain-containing protein 3(gene name synonym)|uniprotkb:EGLN3(gene name)|psi-mi:EGLN3(display_short)|uniprotkb:Egl nine homolog 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765617	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0018126"(protein hydroxylation)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|mint:Q9H6Z9|reactome:R-HSA-1234176|ensembl:ENSG00000129521(gene)|ensembl:ENST00000250457(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_071356.1|refseq:NP_001295032.1	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:qkcZeQzvxL+8efCa0kakLjwXDt89606	intact-crc:708CDB9E5BB5C315|rigid:5/mDWal8cSqu6JkoVfmR5ZSLqCw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q96FV9	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1765605|uniprotkb:Q15219|uniprotkb:B2RBP6|uniprotkb:Q64I72|uniprotkb:Q64I73|intact:EBI-28984554|ensembl:ENSP00000261600	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:thoc1_human(display_long)|uniprotkb:hTREX84(gene name synonym)|uniprotkb:THOC1(gene name)|psi-mi:THOC1(display_short)|uniprotkb:HPR1(gene name synonym)|uniprotkb:Nuclear matrix protein p84(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765617	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	refseq:NP_005122.2|ensembl:ENSP00000261600|ensembl:ENSG00000079134(gene)|ensembl:ENST00000261600(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000346"(transcription export complex)|go:"GO:0000347"(THO complex)|go:"GO:0000445"(THO complex part of transcription export complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0031297"(replication fork processing)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|go:"GO:0048297"(negative regulation of isotype switching to IgA isotypes)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR021861|mint:Q96FV9|rcsb pdb:1WXP|rcsb pdb:7APK|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:D+lk5iFzcmd1bQRa2cx/nUyq4sI9606	intact-crc:708CDB9E5BB5C315|rigid:5/mDWal8cSqu6JkoVfmR5ZSLqCw	false	-	sufficient binding region:578-657	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q9H6Z9	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1175354|uniprotkb:Q2TA79|uniprotkb:Q3B8N4|uniprotkb:Q6P1R2|ensembl:ENSP00000250457	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:egln3_human(display_long)|uniprotkb:Hypoxia-inducible factor prolyl hydroxylase 3(gene name synonym)|uniprotkb:HPH-1(gene name synonym)|uniprotkb:Prolyl hydroxylase domain-containing protein 3(gene name synonym)|uniprotkb:EGLN3(gene name)|psi-mi:EGLN3(display_short)|uniprotkb:Egl nine homolog 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765656	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0018126"(protein hydroxylation)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|mint:Q9H6Z9|reactome:R-HSA-1234176|ensembl:ENSG00000129521(gene)|ensembl:ENST00000250457(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_071356.1|refseq:NP_001295032.1	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:qkcZeQzvxL+8efCa0kakLjwXDt89606	intact-crc:004FED3BDCB46F86|rigid:4Ux3q+o7APyw/vV0Mmkh+rFDyCw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q9Y6W3	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1765641|ensembl:ENSP00000253693	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:can7_human(display_long)|uniprotkb:CAPN7(gene name)|psi-mi:CAPN7(display_short)|uniprotkb:PALBH(gene name synonym)|uniprotkb:PalB homolog(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765656	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	refseq:NP_055111.1|ensembl:ENSG00000131375(gene)|ensembl:ENST00000253693(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090541"(MIT domain binding)|go:"GO:0097264"(self proteolysis)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR007330(MIT)|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR036181|interpro:IPR036213|interpro:IPR038765|mint:Q9Y6W3|rcsb pdb:2QFE|reactome:R-HSA-1474228	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:tRDBeVQRu1tuCDWtSrve/Y9lWsg9606	intact-crc:004FED3BDCB46F86|rigid:4Ux3q+o7APyw/vV0Mmkh+rFDyCw	false	-	sufficient binding region:536-679	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q9H6Z9	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1175354|uniprotkb:Q2TA79|uniprotkb:Q3B8N4|uniprotkb:Q6P1R2|ensembl:ENSP00000250457	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:egln3_human(display_long)|uniprotkb:Hypoxia-inducible factor prolyl hydroxylase 3(gene name synonym)|uniprotkb:HPH-1(gene name synonym)|uniprotkb:Prolyl hydroxylase domain-containing protein 3(gene name synonym)|uniprotkb:EGLN3(gene name)|psi-mi:EGLN3(display_short)|uniprotkb:Egl nine homolog 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765678	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0018126"(protein hydroxylation)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|mint:Q9H6Z9|reactome:R-HSA-1234176|ensembl:ENSG00000129521(gene)|ensembl:ENST00000250457(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_071356.1|refseq:NP_001295032.1	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The prey YY1AP1 is stated to be 739 aa in length as it is a C-terminal fragment. Isoform 3 in the UniProtKB entry for YY1AP1 corresponds to this length.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:qkcZeQzvxL+8efCa0kakLjwXDt89606	intact-crc:47F163B00DEB9DA6|rigid:ddmeRdICTPLYSV/cK7Bt/r3lE7M	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q9H869-3	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-946146|ensembl:ENSP00000352134|ensembl:ENSP00000355298	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:q9h869-3(display_long)|uniprotkb:YY1AP1(gene name)|psi-mi:YY1AP1(display_short)|uniprotkb:HCCA2(gene name synonym)|uniprotkb:YY1AP(gene name synonym)|uniprotkb:Hepatocellular carcinoma susceptibility protein(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765678	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	intact:EBI-946122(yyap1_human)|ensembl:ENSG00000163374(gene)|ensembl:ENST00000359205(transcript)|ensembl:ENST00000361831(transcript)	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The prey YY1AP1 is stated to be 739 aa in length as it is a C-terminal fragment. Isoform 3 in the UniProtKB entry for YY1AP1 corresponds to this length.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:lcxmsf+Zu+PuIYWSoUfWQcmEgms9606	intact-crc:47F163B00DEB9DA6|rigid:ddmeRdICTPLYSV/cK7Bt/r3lE7M	false	-	sufficient binding region:604-739	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q9H6Z9	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1175354|uniprotkb:Q2TA79|uniprotkb:Q3B8N4|uniprotkb:Q6P1R2|ensembl:ENSP00000250457	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:egln3_human(display_long)|uniprotkb:Hypoxia-inducible factor prolyl hydroxylase 3(gene name synonym)|uniprotkb:HPH-1(gene name synonym)|uniprotkb:Prolyl hydroxylase domain-containing protein 3(gene name synonym)|uniprotkb:EGLN3(gene name)|psi-mi:EGLN3(display_short)|uniprotkb:Egl nine homolog 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765723	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0018126"(protein hydroxylation)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|mint:Q9H6Z9|reactome:R-HSA-1234176|ensembl:ENSG00000129521(gene)|ensembl:ENST00000250457(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_071356.1|refseq:NP_001295032.1	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:qkcZeQzvxL+8efCa0kakLjwXDt89606	intact-crc:70272809500D5F2F|rigid:7xrMCcHcD1lUU65HE15Y+Uzkp9I	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q93062-3	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-740343|ensembl:ENSP00000340176	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:q93062-3(display_long)|uniprotkb:RBPMS(gene name)|psi-mi:RBPMS(display_short)|uniprotkb:HERMES(gene name synonym)|uniprotkb:Heart and RRM expressed sequence(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765723	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	intact:EBI-740322(rbpms_human)|uniprotkb:Q93062-3(isoform-parent)|ensembl:ENSG00000157110(gene)|ensembl:ENST00000339877(transcript)	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:nlPMQAJoKEbPYBwsL3xodmCKd7c9606	intact-crc:70272809500D5F2F|rigid:7xrMCcHcD1lUU65HE15Y+Uzkp9I	false	-	sufficient binding region:23-201	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q9H6Z9	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1175354|uniprotkb:Q2TA79|uniprotkb:Q3B8N4|uniprotkb:Q6P1R2|ensembl:ENSP00000250457	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:egln3_human(display_long)|uniprotkb:Hypoxia-inducible factor prolyl hydroxylase 3(gene name synonym)|uniprotkb:HPH-1(gene name synonym)|uniprotkb:Prolyl hydroxylase domain-containing protein 3(gene name synonym)|uniprotkb:EGLN3(gene name)|psi-mi:EGLN3(display_short)|uniprotkb:Egl nine homolog 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765730	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0018126"(protein hydroxylation)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|mint:Q9H6Z9|reactome:R-HSA-1234176|ensembl:ENSG00000129521(gene)|ensembl:ENST00000250457(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_071356.1|refseq:NP_001295032.1	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:qkcZeQzvxL+8efCa0kakLjwXDt89606	intact-crc:532AD53C4A166017|rigid:RwhQM19t+GewtP/5JCsJ8XP13o4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q8TDY2	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1047793|uniprotkb:Q92601|uniprotkb:Q8WVU9|uniprotkb:Q86YR4|ensembl:ENSP00000025008	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:rbcc1_human(display_long)|uniprotkb:RB1CC1(gene name)|psi-mi:RB1CC1(display_short)|uniprotkb:KIAA0203(gene name synonym)|uniprotkb:RBICC(gene name synonym)|uniprotkb:FAK family kinase-interacting protein of 200 kDa(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765730	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	refseq:NP_001077086.1|refseq:NP_055596.3|refseq:XP_011515945.1|refseq:XP_016869596.1|ensembl:ENSG00000023287(gene)|ensembl:ENST00000025008(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005764"(lysosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007049"(cell cycle)|go:"GO:0007507"(heart development)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061709"(reticulophagy)|go:"GO:0061723"(glycophagy)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR019460|interpro:IPR040040|mint:Q8TDY2|rcsb pdb:6DCE|rcsb pdb:6GMA|rcsb pdb:7CZG|rcsb pdb:7CZM|rcsb pdb:7D0E|reactome:R-HSA-1632852|dip:DIP-45969N	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:3qWsqPCX1PTO00mfVMJejr7QLwU9606	intact-crc:532AD53C4A166017|rigid:RwhQM19t+GewtP/5JCsJ8XP13o4	false	-	sufficient binding region:1407-1594	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q9H6Z9	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1175354|uniprotkb:Q2TA79|uniprotkb:Q3B8N4|uniprotkb:Q6P1R2|ensembl:ENSP00000250457	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:egln3_human(display_long)|uniprotkb:Hypoxia-inducible factor prolyl hydroxylase 3(gene name synonym)|uniprotkb:HPH-1(gene name synonym)|uniprotkb:Prolyl hydroxylase domain-containing protein 3(gene name synonym)|uniprotkb:EGLN3(gene name)|psi-mi:EGLN3(display_short)|uniprotkb:Egl nine homolog 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765737	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0018126"(protein hydroxylation)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|mint:Q9H6Z9|reactome:R-HSA-1234176|ensembl:ENSG00000129521(gene)|ensembl:ENST00000250457(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_071356.1|refseq:NP_001295032.1	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:qkcZeQzvxL+8efCa0kakLjwXDt89606	intact-crc:DD270D9AC894BBEC|rigid:T6ZTw/fAX4M6WRehdrgLh0d+xoQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:Q14318	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-724839|uniprotkb:Q53GU3|uniprotkb:Q7Z349|uniprotkb:Q86YK6|ensembl:ENSP00000222308|ensembl:ENSP00000472302|uniprotkb:C8C9T5	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:fkbp8_human(display_long)|uniprotkb:FK506-binding protein 8(gene name synonym)|uniprotkb:38 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBPR38(gene name synonym)|uniprotkb:FKBP8(gene name)|psi-mi:FKBP8(display_short)|uniprotkb:FKBP38(gene name synonym)|uniprotkb:Rotamase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765737	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	refseq:NP_036313.3|refseq:NP_001295302.1|go:"GO:0001708"(cell fate specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0046872"(metal ion binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:Q14318|ensembl:ENSG00000105701(gene)|rcsb pdb:2AWG|rcsb pdb:2D9F|rcsb pdb:2F2D|rcsb pdb:2MF9|rcsb pdb:3EY6|rcsb pdb:5MGX|reactome:R-HSA-5689880|ensembl:ENST00000222308(transcript)|ensembl:ENST00000596558(transcript)|refseq:XP_011526165.1|dip:DIP-42200N	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:Table 2|comment:This interaction was dependent upon the presence of the prolylhydroxylase PHD3.|comment:The isoform of VHL used as the interactor has aa 1-53 missing, so corresponding to the construct used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:CpZqwry5szPluwNMwWXshCIMUvY9606	intact-crc:DD270D9AC894BBEC|rigid:T6ZTw/fAX4M6WRehdrgLh0d+xoQ	false	-	sufficient binding region:154-401	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40337-3	uniprotkb:O75912	intact:EBI-301270|intact:EBI-8411390|intact:MINT-133264|intact:EBI-8411360	intact:EBI-1765520|uniprotkb:Q9NZ49|uniprotkb:A4D1Q9|intact:EBI-28976042|ensembl:ENSP00000288490	psi-mi:p40337-3(display_long)|uniprotkb:VHL19(isoform synonym)|uniprotkb:"VHLp18(MEA)"(isoform synonym)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:Protein G7(gene name synonym)|uniprotkb:pVHL(gene name synonym)	psi-mi:dgki_human(display_long)|uniprotkb:DGKI(gene name)|psi-mi:DGKI(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765840	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-301246(vhl_human)|uniprotkb:P40337-3(isoform-parent)	refseq:NP_004708.1|ensembl:ENSP00000288490|refseq:NP_001308637.1|refseq:NP_001308638.1|refseq:NP_001308639.1|ensembl:ENSG00000157680(gene)|ensembl:ENST00000288490(transcript)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0004143"(diacylglycerol kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030168"(platelet activation)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046834"(lipid phosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097060"(synaptic membrane)|interpro:IPR000756(Diacylglycerol kinase accessory region)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR002110(Ankyrin)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037607|reactome:R-HSA-114508	-	isoform-comment:Produced by alternative initiation at Met-54 of isoform 1.	-	figure legend:6|comment:The isoform of VHL used as the interactor has aa 1-53 missing.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/04/14	2014/10/16	rogid:OVR2JNrrtr965RSGfZnZycZELd49606	rogid:ht89r7Xcvhg9W3KgyvPl3gjkHz09606	intact-crc:B1E2CF95410BD1C2|rigid:albnWWq9A4/T2XYndcCYdvtsEso	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75912	uniprotkb:P40337	intact:EBI-1765520|uniprotkb:Q9NZ49|uniprotkb:A4D1Q9|intact:EBI-28976042|ensembl:ENSP00000288490	intact:EBI-301246|uniprotkb:Q13599|uniprotkb:B2RE45|uniprotkb:Q6PDA9|ensembl:ENSP00000256474	psi-mi:dgki_human(display_long)|uniprotkb:DGKI(gene name)|psi-mi:DGKI(display_short)	psi-mi:vhl_human(display_long)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:pVHL(gene name synonym)|uniprotkb:Protein G7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bex et al. (2007)	pubmed:17986458	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765882	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004708.1|ensembl:ENSP00000288490|refseq:NP_001308637.1|refseq:NP_001308638.1|refseq:NP_001308639.1|ensembl:ENSG00000157680(gene)|ensembl:ENST00000288490(transcript)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0004143"(diacylglycerol kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030168"(platelet activation)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046834"(lipid phosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097060"(synaptic membrane)|interpro:IPR000756(Diacylglycerol kinase accessory region)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR002110(Ankyrin)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037607|reactome:R-HSA-114508	rcsb pdb:6BVB|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:4W9I|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:4W9J|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:4W9K|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6SIS|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-1234176|reactome:R-HSA-3232142|rcsb pdb:4W9L|reactome:R-HSA-8951664|rcsb pdb:4WQO|reactome:R-HSA-9682706|reactome:R-HSA-9694686|reactome:R-HSA-9706019|reactome:R-HSA-983168|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|ensembl:ENSG00000134086(gene)|ensembl:ENST00000256474(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050821"(protein stabilization)|go:"GO:0061418"(regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002714(Tumour suppressor protein, von Hippel-Lindau disease)|interpro:IPR022772|interpro:IPR024048|interpro:IPR024053|interpro:IPR036208|interpro:IPR037139|interpro:IPR037140|mint:P40337|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|refseq:NP_000542.1|refseq:NP_937799.1|dip:DIP-32585N	-	-	-	figure legend:6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/04/14	2014/10/16	rogid:ht89r7Xcvhg9W3KgyvPl3gjkHz09606	rogid:KaCKDTSj0xPG9YmfFsXIbkRt3A89606	intact-crc:538DF383DA65EAAF|rigid:8mKLxgwPNchQwpKvEbSe62wsEHg	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)