#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0C5U5	uniprotkb:Q8QPG0	intact:EBI-7673978|intact:MINT-6505355	intact:EBI-7673995|intact:MINT-6505366	psi-mi:pb1f2_i00a0(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)	psi-mi:pa_i00a0(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Poole et al. (2007)	pubmed:17967456|imex:IM-14058|mint:MINT-6505261	taxid:176674(i00a0)|taxid:176674("Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)")	taxid:176674(i00a0)|taxid:176674("Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7674027|mint:MINT-6505371|imex:IM-14058-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016020"(membrane)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044192"(host cell mitochondrial inner membrane)|mint:P0C5U5|interpro:IPR021045|mint:MINT-6505373(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0075526"(cap snatching)|mint:Q8QPG0|interpro:IPR038372|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|mint:MINT-6505375(identity)	-	function:"Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Its level of expression differ greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. May also act in trans: extracellular PB1-F2 released by infected cells could potentially inactivate hosts cell recruitment to the site of infection. During early stage of infection, may predispose the mitochondria to permeability transition through interaction with human SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis"|comment:mint	function:Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication|comment:mint	figure legend:F3A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2008/04/09	2014/10/16	rogid:Gpwni21v542zyoQ/0b31NKkBAhc176674	rogid:Zc9fB/Px4HaMgvlKV/FvY7hdHYQ176674	intact-crc:6207A2997B9DB5D7|rigid:IBiMmoE73n+eMhmLf8tf1w2apVI	false	mutation decreasing interaction:64-90(MINT-6505386)	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P0C5U5	uniprotkb:Q8QPG7	intact:EBI-7673978|intact:MINT-6505355	intact:EBI-7674009|intact:MINT-6505361	psi-mi:pb1f2_i00a0(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)	psi-mi:pb2_i00a0(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Poole et al. (2007)	pubmed:17967456|imex:IM-14058|mint:MINT-6505261	taxid:176674(i00a0)|taxid:176674("Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)")	taxid:176674(i00a0)|taxid:176674("Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7674027|mint:MINT-6505371|imex:IM-14058-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016020"(membrane)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044192"(host cell mitochondrial inner membrane)|mint:P0C5U5|interpro:IPR021045|mint:MINT-6505373(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|mint:Q8QPG7|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|mint:MINT-6505374(identity)	-	function:"Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Its level of expression differ greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. May also act in trans: extracellular PB1-F2 released by infected cells could potentially inactivate hosts cell recruitment to the site of infection. During early stage of infection, may predispose the mitochondria to permeability transition through interaction with human SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis"|comment:mint	function:Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication|comment:mint	figure legend:F3A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2008/04/09	2014/10/16	rogid:Gpwni21v542zyoQ/0b31NKkBAhc176674	rogid:vH1uddX9C7PWGcM5hbLogo8Ho7I176674	intact-crc:6207A2997B9DB5D7|rigid:IBiMmoE73n+eMhmLf8tf1w2apVI	false	mutation decreasing interaction:64-90(MINT-6505386)	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8QPG7	uniprotkb:Q8QPG0	intact:EBI-7674009|intact:MINT-6505361	intact:EBI-7673995|intact:MINT-6505366	psi-mi:pb2_i00a0(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym)	psi-mi:pa_i00a0(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Poole et al. (2007)	pubmed:17967456|imex:IM-14058|mint:MINT-6505261	taxid:176674(i00a0)|taxid:176674("Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)")	taxid:176674(i00a0)|taxid:176674("Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7674048|mint:MINT-6505390|imex:IM-14058-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|mint:Q8QPG7|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|mint:MINT-6505392(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0075526"(cap snatching)|mint:Q8QPG0|interpro:IPR038372|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|mint:MINT-6505398(identity)	-	function:Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication|comment:mint	function:Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication|comment:mint	figure legend:F3A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2008/04/09	2014/10/16	rogid:vH1uddX9C7PWGcM5hbLogo8Ho7I176674	rogid:Zc9fB/Px4HaMgvlKV/FvY7hdHYQ176674	intact-crc:46D933495856E5EC|rigid:IBiMmoE73n+eMhmLf8tf1w2apVI	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8QPG7	uniprotkb:P0C5U5	intact:EBI-7674009|intact:MINT-6505361	intact:EBI-7673978|intact:MINT-6505355	psi-mi:pb2_i00a0(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym)	psi-mi:pb1f2_i00a0(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Poole et al. (2007)	pubmed:17967456|imex:IM-14058|mint:MINT-6505261	taxid:176674(i00a0)|taxid:176674("Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)")	taxid:176674(i00a0)|taxid:176674("Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7674048|mint:MINT-6505390|imex:IM-14058-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|mint:Q8QPG7|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|mint:MINT-6505392(identity)	go:"GO:0016020"(membrane)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044192"(host cell mitochondrial inner membrane)|mint:P0C5U5|interpro:IPR021045|mint:MINT-6505394(identity)	-	function:Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication|comment:mint	function:"Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Its level of expression differ greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. May also act in trans: extracellular PB1-F2 released by infected cells could potentially inactivate hosts cell recruitment to the site of infection. During early stage of infection, may predispose the mitochondria to permeability transition through interaction with human SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis"|comment:mint	figure legend:F3A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2008/04/09	2014/10/16	rogid:vH1uddX9C7PWGcM5hbLogo8Ho7I176674	rogid:Gpwni21v542zyoQ/0b31NKkBAhc176674	intact-crc:46D933495856E5EC|rigid:IBiMmoE73n+eMhmLf8tf1w2apVI	false	-	mutation decreasing interaction:64-90(MINT-6505395)	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8QPG7	uniprotkb:P0C5U5	intact:EBI-7674009|intact:MINT-6505361	intact:EBI-7673978|intact:MINT-6505355	psi-mi:pb2_i00a0(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym)	psi-mi:pb1f2_i00a0(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)	psi-mi:"MI:0096"(pull down)	Poole et al. (2007)	pubmed:17967456|imex:IM-14058|mint:MINT-6505261	taxid:176674(i00a0)|taxid:176674("Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)")	taxid:176674(i00a0)|taxid:176674("Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7674099|mint:MINT-6505419|imex:IM-14058-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|mint:Q8QPG7|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|mint:MINT-6505421(identity)	go:"GO:0016020"(membrane)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044192"(host cell mitochondrial inner membrane)|mint:P0C5U5|interpro:IPR021045|mint:MINT-6505423(identity)	-	function:Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication|comment:mint	function:"Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Its level of expression differ greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. May also act in trans: extracellular PB1-F2 released by infected cells could potentially inactivate hosts cell recruitment to the site of infection. During early stage of infection, may predispose the mitochondria to permeability transition through interaction with human SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis"|comment:mint	figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/04/09	2014/10/16	rogid:vH1uddX9C7PWGcM5hbLogo8Ho7I176674	rogid:Gpwni21v542zyoQ/0b31NKkBAhc176674	intact-crc:0A737CA5A0849347|rigid:jEhi8F7wMNrl/pfuWII8Wi33HnU	false	-	glutathione s tranferase tag:?-?(MINT-6505431)|binding-associated region:16-90(MINT-6505433)	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C5U5	uniprotkb:Q8QPG7	intact:EBI-7673978|intact:MINT-6505355	intact:EBI-7674009|intact:MINT-6505361	psi-mi:pb1f2_i00a0(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)	psi-mi:pb2_i00a0(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Poole et al. (2007)	pubmed:17967456|imex:IM-14058|mint:MINT-6505261	taxid:176674(i00a0)|taxid:176674("Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)")	taxid:176674(i00a0)|taxid:176674("Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7674155|mint:MINT-6505438|imex:IM-14058-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016020"(membrane)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044192"(host cell mitochondrial inner membrane)|mint:P0C5U5|interpro:IPR021045|mint:MINT-6505440(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|mint:Q8QPG7|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|mint:MINT-6505446(identity)	-	function:"Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Its level of expression differ greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. May also act in trans: extracellular PB1-F2 released by infected cells could potentially inactivate hosts cell recruitment to the site of infection. During early stage of infection, may predispose the mitochondria to permeability transition through interaction with human SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis"|comment:mint	function:Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication|comment:mint	figure legend:F1B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/04/09	2014/10/16	rogid:Gpwni21v542zyoQ/0b31NKkBAhc176674	rogid:vH1uddX9C7PWGcM5hbLogo8Ho7I176674	intact-crc:FBEE4FBBE42FCB8B|rigid:jEhi8F7wMNrl/pfuWII8Wi33HnU	false	binding-associated region:45-79(MINT-6505441)|glutathione s tranferase tag:?-?(MINT-6505443)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)