#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0A8V2	uniprotkb:P0A8T7	intact:EBI-544996|uniprotkb:P00575|uniprotkb:P00576|uniprotkb:P78242|uniprotkb:Q2M8S3|ensemblbacteria:AAC76961|ensemblbacteria:BAE77333	intact:EBI-543604|uniprotkb:P00577|uniprotkb:P00578|uniprotkb:P78134|uniprotkb:Q2M8S4|ensemblbacteria:AAC76962|ensemblbacteria:BAE77332	psi-mi:rpob_ecoli(display_long)|uniprotkb:rpoB(gene name)|psi-mi:rpoB(display_short)|uniprotkb:groN(gene name synonym)|uniprotkb:nitB(gene name synonym)|uniprotkb:rif(gene name synonym)|uniprotkb:ron(gene name synonym)|uniprotkb:stl(gene name synonym)|uniprotkb:stv(gene name synonym)|uniprotkb:tabD(gene name synonym)|uniprotkb:b3987(locus name)|uniprotkb:Transcriptase subunit beta(gene name synonym)|uniprotkb:RNA polymerase subunit beta(gene name synonym)|uniprotkb:JW3950(locus name)	psi-mi:rpoc_ecoli(display_long)|uniprotkb:rpoC(gene name)|psi-mi:rpoC(display_short)|uniprotkb:tabB(gene name synonym)|uniprotkb:b3988(locus name)|uniprotkb:JW3951(locus name)|uniprotkb:Transcriptase subunit beta'(gene name synonym)|uniprotkb:RNA polymerase subunit beta'(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Weerasekera et al. (2007)	imex:IM-11894|pubmed:17960736	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1780332|imex:IM-11894-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_418414.1|refseq:WP_000263098.1|ensemblbacteria:AAC76961(transcript)|ensemblbacteria:b3987(gene)|ensemblbacteria:BAE77333(gene)|ensemblbacteria:BAE77333(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016020"(membrane)|go:"GO:0032549"(ribonucleoside binding)|go:"GO:0046677"(response to antibiotic)|interpro:IPR007120(DNA-directed RNA polymerase, subunit 2, domain 6)|interpro:IPR007121(RNA polymerase, beta subunit, conserved site)|interpro:IPR007641(RNA polymerase Rpb2, domain 7)|interpro:IPR007642(RNA polymerase Rpb2, domain 2)|interpro:IPR007644(RNA polymerase, beta subunit, protrusion)|interpro:IPR007645(RNA polymerase Rpb2, domain 3)|interpro:IPR010243(DNA-directed RNA polymerase, beta subunit, bacterial-type)|interpro:IPR014724(RNA polymerase Rpb2, OB-fold)|interpro:IPR015712(DNA-directed RNA polymerase, subunit 2)|interpro:IPR019462|interpro:IPR037033|interpro:IPR037034|interpro:IPR042107|rcsb pdb:3IYD|rcsb pdb:3LTI|rcsb pdb:3LU0|rcsb pdb:3T72|rcsb pdb:3TBI|rcsb pdb:4JK1|rcsb pdb:4JK2|rcsb pdb:4KMU|rcsb pdb:4KN4|rcsb pdb:4KN7|rcsb pdb:4MEX|rcsb pdb:4MEY|rcsb pdb:4S20|rcsb pdb:4XSX|rcsb pdb:4XSY|rcsb pdb:4XSZ|rcsb pdb:4YG2|rcsb pdb:4YLN|rcsb pdb:4YLO|rcsb pdb:4YLP|rcsb pdb:4ZH2|rcsb pdb:4ZH3|rcsb pdb:4ZH4|rcsb pdb:5BYH|rcsb pdb:5EZK|rcsb pdb:5IPL|rcsb pdb:5IPM|rcsb pdb:5IPN|rcsb pdb:5MS0|rcsb pdb:5MY1|rcsb pdb:5NSR|rcsb pdb:5NSS|rcsb pdb:5NWT|rcsb pdb:5UAC|rcsb pdb:6GH5|rcsb pdb:6GH6|rcsb pdb:6JBQ|rcsb pdb:6JNX|rcsb pdb:6K4Y|rcsb pdb:6KJ6|rcsb pdb:6LDI|rcsb pdb:6N4C|rcsb pdb:6N57|rcsb pdb:6N58|rcsb pdb:6N60|rcsb pdb:6N61|rcsb pdb:6OMF|rcsb pdb:6OUL|rcsb pdb:6P18|rcsb pdb:6P19|rcsb pdb:6P1K|rcsb pdb:6PSQ|rcsb pdb:6PSR|rcsb pdb:6PSS|rcsb pdb:6PST|rcsb pdb:6PSU|rcsb pdb:6PSV|rcsb pdb:6PSW|rcsb pdb:6R9B|rcsb pdb:6R9G|rcsb pdb:6RH3|rcsb pdb:6RI7|rcsb pdb:6RI9|rcsb pdb:6RIN|rcsb pdb:6RIP|rcsb pdb:6TQN|rcsb pdb:6TQO|rcsb pdb:6UTV|rcsb pdb:6VJS|rcsb pdb:6WMU|rcsb pdb:6X2F|rcsb pdb:6X2N|rcsb pdb:6X43|rcsb pdb:6X4W|rcsb pdb:6X4Y|rcsb pdb:6X50|rcsb pdb:6XAS|rcsb pdb:6XAV|rcsb pdb:6Z9P|rcsb pdb:6Z9Q|rcsb pdb:6Z9R|rcsb pdb:6Z9S|rcsb pdb:6Z9T|rcsb pdb:6ZTL|rcsb pdb:7ADB|rcsb pdb:7ADC|rcsb pdb:7ADD|rcsb pdb:7ADE|rcsb pdb:7C17|rcsb pdb:7C97|rcsb pdb:7CHW|rcsb pdb:7KHB|rcsb pdb:7KHC|rcsb pdb:7KHE|rcsb pdb:7KHI|rcsb pdb:5UAG|rcsb pdb:5UAH|rcsb pdb:5UAJ|rcsb pdb:5UAL|rcsb pdb:5UAQ|rcsb pdb:5VSW|rcsb pdb:5VT0|rcsb pdb:5W1S|rcsb pdb:5W1T|rcsb pdb:6ALF|rcsb pdb:6ALG|rcsb pdb:6ALH|rcsb pdb:6ASX|rcsb pdb:6BJS|rcsb pdb:6BYU|rcsb pdb:6C6S|rcsb pdb:6C6T|rcsb pdb:6C6U|rcsb pdb:6C9Y|rcsb pdb:6CA0|rcsb pdb:6CUX|rcsb pdb:6FLP|rcsb pdb:6FLQ|rcsb pdb:6GFW|dip:DIP-35777N	interpro:IPR012754(DNA-directed RNA polymerase, subunit beta-prime)|interpro:IPR038120|interpro:IPR042102|rcsb pdb:2AUK|rcsb pdb:2LMC|rcsb pdb:3IYD|rcsb pdb:3LU0|rcsb pdb:4IQZ|rcsb pdb:4JK1|rcsb pdb:4JK2|rcsb pdb:4KMU|rcsb pdb:4KN4|rcsb pdb:4KN7|rcsb pdb:4MEX|rcsb pdb:4MEY|rcsb pdb:4XSX|rcsb pdb:4XSY|rcsb pdb:4XSZ|rcsb pdb:4YG2|rcsb pdb:4YLN|ensemblbacteria:AAC76962(transcript)|ensemblbacteria:b3988(gene)|ensemblbacteria:BAE77332(gene)|ensemblbacteria:BAE77332(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0046677"(response to antibiotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|refseq:NP_418415.1|rcsb pdb:4YLP|rcsb pdb:4ZH2|rcsb pdb:4ZH3|rcsb pdb:4ZH4|rcsb pdb:5BYH|rcsb pdb:5EZK|rcsb pdb:5IPL|rcsb pdb:5IPM|rcsb pdb:5IPN|rcsb pdb:5MS0|rcsb pdb:5MY1|rcsb pdb:5NSR|rcsb pdb:5NSS|rcsb pdb:5NWT|rcsb pdb:5UAC|rcsb pdb:5UAG|rcsb pdb:5UAH|rcsb pdb:5UAJ|rcsb pdb:5UAL|rcsb pdb:5UAQ|rcsb pdb:5VSW|rcsb pdb:5VT0|rcsb pdb:5W1S|rcsb pdb:5W1T|rcsb pdb:6ALF|rcsb pdb:6ALG|rcsb pdb:6ALH|rcsb pdb:6ASX|rcsb pdb:6BJS|rcsb pdb:6BYU|rcsb pdb:6C6S|rcsb pdb:6C6T|rcsb pdb:6C6U|rcsb pdb:6C9Y|rcsb pdb:6CA0|rcsb pdb:6CUX|rcsb pdb:6FLP|rcsb pdb:6FLQ|rcsb pdb:6GFW|rcsb pdb:6GH5|rcsb pdb:6GH6|rcsb pdb:6JBQ|rcsb pdb:6JNX|rcsb pdb:6K4Y|rcsb pdb:6KJ6|rcsb pdb:6LDI|rcsb pdb:6N4C|rcsb pdb:6N57|rcsb pdb:6N58|rcsb pdb:6N60|rcsb pdb:6N61|rcsb pdb:6OMF|rcsb pdb:6P18|rcsb pdb:6P19|rcsb pdb:6P1K|rcsb pdb:6PSQ|rcsb pdb:6PSR|rcsb pdb:6PSS|rcsb pdb:6PST|rcsb pdb:6PSU|rcsb pdb:6PSV|rcsb pdb:6PSW|rcsb pdb:6R9B|rcsb pdb:6R9G|rcsb pdb:6RH3|rcsb pdb:6RI7|rcsb pdb:6RI9|rcsb pdb:6RIN|rcsb pdb:6RIP|rcsb pdb:6TQN|rcsb pdb:6TQO|rcsb pdb:6UTV|rcsb pdb:6UTW|rcsb pdb:6UTX|rcsb pdb:6UTY|rcsb pdb:6UTZ|rcsb pdb:6UU0|rcsb pdb:6UU1|rcsb pdb:6UU2|rcsb pdb:6UU3|rcsb pdb:6UU4|rcsb pdb:6UU5|rcsb pdb:6UU6|rcsb pdb:6UU7|rcsb pdb:6UU8|rcsb pdb:6UU9|rcsb pdb:6UUA|rcsb pdb:6UUB|rcsb pdb:6UUC|rcsb pdb:6VJS|rcsb pdb:6WMU|rcsb pdb:6XAS|rcsb pdb:6XAV|rcsb pdb:7C17|rcsb pdb:7C97|rcsb pdb:7CHW|rcsb pdb:7KHB|rcsb pdb:7KHC|rcsb pdb:7KHE|rcsb pdb:7KHI|refseq:WP_000653944.1|dip:DIP-35803N|rcsb pdb:4YLO	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1, Supplementary Table 1, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/25	2014/10/16	rogid:K9pRCxbEIBkKUFwpFYd0/YJ2n2483333	rogid:uZC9aRrl+QIT7zZtcO7WPVedhnA83333	intact-crc:9FD045EA6A7B76F0|rigid:hZ2R/0XxUhAlvOF2CLA/o1xRmm8	false	sufficient binding region:131-238|sufficient binding region:316-369|sufficient binding region:430-459	sufficient binding region:933-1025|sufficient binding region:1190-1260	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P07834	uniprotkb:P52286	intact:EBI-4434|ensemblfungi:YFL009W|uniprotkb:D6VTM1	intact:EBI-4090|uniprotkb:Q07186|uniprotkb:D6VSW0|ensemblfungi:YDR328C	psi-mi:cdc4_yeast(display_long)|uniprotkb:CDC4(gene name)|psi-mi:CDC4(display_short)|uniprotkb:YFL009W(locus name)|uniprotkb:F-box protein CDC4(gene name synonym)|uniprotkb:E3 ubiquitin ligase complex SCF subunit CDC4(gene name synonym)	psi-mi:skp1_yeast(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:CBF3D(gene name synonym)|uniprotkb:YDR328C(locus name)|uniprotkb:D9798.14(orf name)|uniprotkb:Centromere DNA-binding protein complex CBF3 subunit D(gene name synonym)|uniprotkb:E3 ubiquitin ligase complex SCF subunit SKP1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Weerasekera et al. (2007)	imex:IM-11894|pubmed:17960736	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1780350|imex:IM-11894-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-SCE-174113|reactome:R-SCE-8951664|reactome:R-SCE-983168|ensemblfungi:YFL009W(gene)|ensemblfungi:YFL009W_mRNA(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030686"(90S preribosome)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0043130"(ubiquitin binding)|refseq:NP_116585.1|sgd:S000001885|dip:DIP-1625N|go:"GO:0043224"(nuclear SCF ubiquitin ligase complex)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR031740|interpro:IPR036047|interpro:IPR036322|rcsb pdb:1NEX|rcsb pdb:2P63|rcsb pdb:3MKS|rcsb pdb:3V7D	sgd:S000002736|refseq:NP_010615.3|dip:DIP-1236N|mint:P52286|ensemblfungi:YDR328C(gene)|ensemblfungi:YDR328C_mRNA(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0000921"(septin ring assembly)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010458"(exit from mitosis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031518"(CBF3 complex)|go:"GO:0034622"|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043291"(RAVE complex)|go:"GO:0045116"(protein neddylation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|rcsb pdb:1NEX|rcsb pdb:3MKS|rcsb pdb:3V7D|rcsb pdb:5AN3|rcsb pdb:6F07|rcsb pdb:6FE8|rcsb pdb:6GSA|rcsb pdb:6GYP|rcsb pdb:6GYS|rcsb pdb:6GYU|rcsb pdb:7K79|reactome:R-SCE-174113|reactome:R-SCE-68949|reactome:R-SCE-8854050|reactome:R-SCE-8951664|reactome:R-SCE-983168	psi-mi:"MI:0469"(intact)	crc64:0348F2F8FA78F3BC	crc64:746DDE6470A69432	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/25	2014/10/16	rogid:KUKB7HDw6k4t7Gb1pDGW8P5J1kw559292	rogid:HO5Uz+KzzWNBubxoXRDNTVi8eIA559292	intact-crc:A2CA9723E3F9F67F|rigid:UqB03WVcGngprAjLKNB09ZbwMAE	false	sufficient binding region:607-744	sufficient binding region:78-130	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)