#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O00506	uniprotkb:Q9BUL8	intact:EBI-618295|ensembl:ENSP00000325748|ensembl:ENSP00000384162|ensembl:ENSP00000385687|uniprotkb:Q15522|uniprotkb:Q5BJF1|uniprotkb:A8K7D2|intact:EBI-5773834|uniprotkb:A8K6Z3|uniprotkb:B7Z9K1	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	psi-mi:stk25_human(display_long)|uniprotkb:STK25(gene name)|psi-mi:STK25(display_short)|uniprotkb:SOK1(gene name synonym)|uniprotkb:YSK1(gene name synonym)|uniprotkb:Sterile 20/oxidant stress-response kinase 1(gene name synonym)|uniprotkb:Ste20-like kinase(gene name synonym)	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1572859|imex:IM-19789-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115694(gene)|ensembl:ENST00000316586(transcript)|ensembl:ENST00000401869(transcript)|ensembl:ENST00000403346(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035060|rcsb pdb:2XIK|rcsb pdb:3W8H|rcsb pdb:4NZW|refseq:NP_006365.2|refseq:NP_001258908.1|refseq:NP_001258909.1|refseq:NP_001269234.1|refseq:NP_001269237.1|refseq:NP_001269236.1|refseq:NP_001258906.1|refseq:NP_001258907.1|dip:DIP-34269N	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	-	-	-	comment:"Interaction appears to be with the C-terminal regulatory domain of STK25 (coordinates not given)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/01/08	2014/10/16	rogid:yg5mghaePpT2LrC7wdG7xSGe0Pw9606	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	intact-crc:69E5A737D95ACDE1|rigid:QGUih/t1+dhdqZFhBjNFKzJrmcA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BUL8	uniprotkb:Q9Y6E0	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	intact:EBI-740175|uniprotkb:O14840|ensembl:ENSP00000365730|uniprotkb:Q5JV92|intact:EBI-1054809	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:stk24_human(display_long)|uniprotkb:STK24(gene name)|psi-mi:STK24(display_short)|uniprotkb:MST3(gene name synonym)|uniprotkb:STK3(gene name synonym)|uniprotkb:STE20-like kinase MST3(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1572864|imex:IM-19789-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	ensembl:ENSG00000102572(gene)|ensembl:ENST00000376547(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0045296"(cadherin binding)|refseq:NP_001027467.2|refseq:NP_003567.2|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3A7F|rcsb pdb:3A7G|rcsb pdb:3A7H|rcsb pdb:3A7I|rcsb pdb:3A7J|rcsb pdb:3CKW|rcsb pdb:3CKX|rcsb pdb:3ZHP|rcsb pdb:4O27|rcsb pdb:4QML|rcsb pdb:4QMM|rcsb pdb:4QMN|rcsb pdb:4QMO|rcsb pdb:4QMP|rcsb pdb:4QMQ|rcsb pdb:4QMS|rcsb pdb:4QMT|rcsb pdb:4QMU|rcsb pdb:4QMV|rcsb pdb:4QMW|rcsb pdb:4QMX|rcsb pdb:4QMY|rcsb pdb:4QMZ|rcsb pdb:4QNA|rcsb pdb:4QO9|rcsb pdb:4U8Z|rcsb pdb:4W8D|rcsb pdb:4W8E|rcsb pdb:7B30|rcsb pdb:7B31|rcsb pdb:7B32|rcsb pdb:7B33|rcsb pdb:7B34|rcsb pdb:7B35|reactome:R-HSA-111465|reactome:R-HSA-75153|dip:DIP-40608N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/01/08	2014/10/16	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	rogid:El6otOj/3rikTQX8EOIz3Eohgsw9606	intact-crc:B53687DD7ACE8463|rigid:GdiHfCQUjI+ZKmhrmkj4+dNc2XQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BUL8	uniprotkb:Q12923	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	intact:EBI-355227|uniprotkb:Q9UDA8|uniprotkb:Q15159|uniprotkb:Q15263|uniprotkb:Q15264|uniprotkb:Q15265|uniprotkb:Q15674|uniprotkb:Q16826|uniprotkb:Q8IWH7|uniprotkb:Q9NYN9|uniprotkb:B2RTR0|ensembl:ENSP00000407249	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:ptn13_human(display_long)|uniprotkb:PTPN13(gene name)|psi-mi:PTPN13(display_short)|uniprotkb:PNP1(gene name synonym)|uniprotkb:PTP1E(gene name synonym)|uniprotkb:PTPL1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1E(gene name synonym)|uniprotkb:PTP-BAS(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase PTPL1(gene name synonym)|uniprotkb:Fas-associated protein-tyrosine phosphatase 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1572868|imex:IM-19789-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	refseq:NP_006255.1|refseq:NP_542414.1|refseq:NP_542415.1|refseq:NP_542416.1|ensembl:ENST00000316707|ensembl:ENSP00000322675|ensembl:ENSP00000407249|ensembl:ENST00000427191|ensembl:ENSP00000408368|ensembl:ENST00000436978|ensembl:ENSP00000394794|ensembl:ENST00000511467|ensembl:ENSP00000426626|dip:DIP-40449N|ensembl:ENSG00000163629(gene)|ensembl:ENST00000411767(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011019(KIND)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012153(Protein-tyrosine phosphatase, non-receptor type-13)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|mint:Q12923|rcsb pdb:1D5G|rcsb pdb:1Q7X|go:"GO:0001933"(negative regulation of protein phosphorylation)|rcsb pdb:1WCH|rcsb pdb:2M0Z|rcsb pdb:2M10|rcsb pdb:3LNX|rcsb pdb:3LNY|rcsb pdb:3PDZ|rcsb pdb:5GLJ|reactome:R-HSA-1660499|reactome:R-HSA-9008059|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273	-	-	-	comment:Appears to bind to the C-terminal phosphatase domain|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/01/08	2014/10/16	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	rogid:PU9d6x+mLnjomT1yfPSVBg0i2Bk9606	intact-crc:0017B78AEE5F6422|rigid:rLZIcI/9cqvUxx+L8l8fbL7rVuU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BUL8	uniprotkb:O00506	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	intact:EBI-618295|ensembl:ENSP00000325748|ensembl:ENSP00000384162|ensembl:ENSP00000385687|uniprotkb:Q15522|uniprotkb:Q5BJF1|uniprotkb:A8K7D2|intact:EBI-5773834|uniprotkb:A8K6Z3|uniprotkb:B7Z9K1	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:stk25_human(display_long)|uniprotkb:STK25(gene name)|psi-mi:STK25(display_short)|uniprotkb:SOK1(gene name synonym)|uniprotkb:YSK1(gene name synonym)|uniprotkb:Sterile 20/oxidant stress-response kinase 1(gene name synonym)|uniprotkb:Ste20-like kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1572879|imex:IM-19789-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	ensembl:ENSG00000115694(gene)|ensembl:ENST00000316586(transcript)|ensembl:ENST00000401869(transcript)|ensembl:ENST00000403346(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035060|rcsb pdb:2XIK|rcsb pdb:3W8H|rcsb pdb:4NZW|refseq:NP_006365.2|refseq:NP_001258908.1|refseq:NP_001258909.1|refseq:NP_001269234.1|refseq:NP_001269237.1|refseq:NP_001269236.1|refseq:NP_001258906.1|refseq:NP_001258907.1|dip:DIP-34269N	-	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/08	2014/10/16	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	rogid:yg5mghaePpT2LrC7wdG7xSGe0Pw9606	intact-crc:24AA26BEF9ECA6F3|rigid:ae8KeCnPtzY7j1QVJIRR5PGnlNw	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BUL8	uniprotkb:Q12923	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	intact:EBI-355227|uniprotkb:Q9UDA8|uniprotkb:Q15159|uniprotkb:Q15263|uniprotkb:Q15264|uniprotkb:Q15265|uniprotkb:Q15674|uniprotkb:Q16826|uniprotkb:Q8IWH7|uniprotkb:Q9NYN9|uniprotkb:B2RTR0|ensembl:ENSP00000407249	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:ptn13_human(display_long)|uniprotkb:PTPN13(gene name)|psi-mi:PTPN13(display_short)|uniprotkb:PNP1(gene name synonym)|uniprotkb:PTP1E(gene name synonym)|uniprotkb:PTPL1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1E(gene name synonym)|uniprotkb:PTP-BAS(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase PTPL1(gene name synonym)|uniprotkb:Fas-associated protein-tyrosine phosphatase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1572879|imex:IM-19789-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	refseq:NP_006255.1|refseq:NP_542414.1|refseq:NP_542415.1|refseq:NP_542416.1|ensembl:ENST00000316707|ensembl:ENSP00000322675|ensembl:ENSP00000407249|ensembl:ENST00000427191|ensembl:ENSP00000408368|ensembl:ENST00000436978|ensembl:ENSP00000394794|ensembl:ENST00000511467|ensembl:ENSP00000426626|dip:DIP-40449N|ensembl:ENSG00000163629(gene)|ensembl:ENST00000411767(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011019(KIND)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012153(Protein-tyrosine phosphatase, non-receptor type-13)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|mint:Q12923|rcsb pdb:1D5G|rcsb pdb:1Q7X|go:"GO:0001933"(negative regulation of protein phosphorylation)|rcsb pdb:1WCH|rcsb pdb:2M0Z|rcsb pdb:2M10|rcsb pdb:3LNX|rcsb pdb:3LNY|rcsb pdb:3PDZ|rcsb pdb:5GLJ|reactome:R-HSA-1660499|reactome:R-HSA-9008059|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273	-	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/08	2014/10/16	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	rogid:PU9d6x+mLnjomT1yfPSVBg0i2Bk9606	intact-crc:24AA26BEF9ECA6F3|rigid:ae8KeCnPtzY7j1QVJIRR5PGnlNw	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BSQ5	uniprotkb:Q9BUL8	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1573160|imex:IM-19789-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	-	-	-	delivery method:Q9BUL8; Q9BSQ5 transfection|figure legend:Fig. 4B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/08	2014/10/16	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	intact-crc:9C5AA6614DD218DC|rigid:nMZbMKQ4LwY5uDFU0wuw9SgXzCI	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BUL8	uniprotkb:O00506	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	intact:EBI-618295|ensembl:ENSP00000325748|ensembl:ENSP00000384162|ensembl:ENSP00000385687|uniprotkb:Q15522|uniprotkb:Q5BJF1|uniprotkb:A8K7D2|intact:EBI-5773834|uniprotkb:A8K6Z3|uniprotkb:B7Z9K1	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:stk25_human(display_long)|uniprotkb:STK25(gene name)|psi-mi:STK25(display_short)|uniprotkb:SOK1(gene name synonym)|uniprotkb:YSK1(gene name synonym)|uniprotkb:Sterile 20/oxidant stress-response kinase 1(gene name synonym)|uniprotkb:Ste20-like kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1572893|imex:IM-19789-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	ensembl:ENSG00000115694(gene)|ensembl:ENST00000316586(transcript)|ensembl:ENST00000401869(transcript)|ensembl:ENST00000403346(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035060|rcsb pdb:2XIK|rcsb pdb:3W8H|rcsb pdb:4NZW|refseq:NP_006365.2|refseq:NP_001258908.1|refseq:NP_001258909.1|refseq:NP_001269234.1|refseq:NP_001269237.1|refseq:NP_001269236.1|refseq:NP_001258906.1|refseq:NP_001258907.1|dip:DIP-34269N	-	-	-	figure legend:Fig. 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/08	2014/10/16	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	rogid:yg5mghaePpT2LrC7wdG7xSGe0Pw9606	intact-crc:F3C447203AACF6E3|rigid:ae8KeCnPtzY7j1QVJIRR5PGnlNw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BUL8	uniprotkb:Q12923	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	intact:EBI-355227|uniprotkb:Q9UDA8|uniprotkb:Q15159|uniprotkb:Q15263|uniprotkb:Q15264|uniprotkb:Q15265|uniprotkb:Q15674|uniprotkb:Q16826|uniprotkb:Q8IWH7|uniprotkb:Q9NYN9|uniprotkb:B2RTR0|ensembl:ENSP00000407249	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:ptn13_human(display_long)|uniprotkb:PTPN13(gene name)|psi-mi:PTPN13(display_short)|uniprotkb:PNP1(gene name synonym)|uniprotkb:PTP1E(gene name synonym)|uniprotkb:PTPL1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1E(gene name synonym)|uniprotkb:PTP-BAS(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase PTPL1(gene name synonym)|uniprotkb:Fas-associated protein-tyrosine phosphatase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1572893|imex:IM-19789-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	refseq:NP_006255.1|refseq:NP_542414.1|refseq:NP_542415.1|refseq:NP_542416.1|ensembl:ENST00000316707|ensembl:ENSP00000322675|ensembl:ENSP00000407249|ensembl:ENST00000427191|ensembl:ENSP00000408368|ensembl:ENST00000436978|ensembl:ENSP00000394794|ensembl:ENST00000511467|ensembl:ENSP00000426626|dip:DIP-40449N|ensembl:ENSG00000163629(gene)|ensembl:ENST00000411767(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011019(KIND)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012153(Protein-tyrosine phosphatase, non-receptor type-13)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|mint:Q12923|rcsb pdb:1D5G|rcsb pdb:1Q7X|go:"GO:0001933"(negative regulation of protein phosphorylation)|rcsb pdb:1WCH|rcsb pdb:2M0Z|rcsb pdb:2M10|rcsb pdb:3LNX|rcsb pdb:3LNY|rcsb pdb:3PDZ|rcsb pdb:5GLJ|reactome:R-HSA-1660499|reactome:R-HSA-9008059|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273	-	-	-	figure legend:Fig. 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/08	2014/10/16	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	rogid:PU9d6x+mLnjomT1yfPSVBg0i2Bk9606	intact-crc:F3C447203AACF6E3|rigid:ae8KeCnPtzY7j1QVJIRR5PGnlNw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BUL8	uniprotkb:O00506	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	intact:EBI-618295|ensembl:ENSP00000325748|ensembl:ENSP00000384162|ensembl:ENSP00000385687|uniprotkb:Q15522|uniprotkb:Q5BJF1|uniprotkb:A8K7D2|intact:EBI-5773834|uniprotkb:A8K6Z3|uniprotkb:B7Z9K1	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:stk25_human(display_long)|uniprotkb:STK25(gene name)|psi-mi:STK25(display_short)|uniprotkb:SOK1(gene name synonym)|uniprotkb:YSK1(gene name synonym)|uniprotkb:Sterile 20/oxidant stress-response kinase 1(gene name synonym)|uniprotkb:Ste20-like kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1572918|imex:IM-19789-6	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	ensembl:ENSG00000115694(gene)|ensembl:ENST00000316586(transcript)|ensembl:ENST00000401869(transcript)|ensembl:ENST00000403346(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035060|rcsb pdb:2XIK|rcsb pdb:3W8H|rcsb pdb:4NZW|refseq:NP_006365.2|refseq:NP_001258908.1|refseq:NP_001258909.1|refseq:NP_001269234.1|refseq:NP_001269237.1|refseq:NP_001269236.1|refseq:NP_001258906.1|refseq:NP_001258907.1|dip:DIP-34269N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 3A|resulting-ptm:Phosphorylation of PDCD10|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/08	2014/10/16	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	rogid:yg5mghaePpT2LrC7wdG7xSGe0Pw9606	intact-crc:C1D39723CF70675F|rigid:QGUih/t1+dhdqZFhBjNFKzJrmcA	false	glutathione s tranferase tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00506	-	intact:EBI-618295|ensembl:ENSP00000325748|ensembl:ENSP00000384162|ensembl:ENSP00000385687|uniprotkb:Q15522|uniprotkb:Q5BJF1|uniprotkb:A8K7D2|intact:EBI-5773834|uniprotkb:A8K6Z3|uniprotkb:B7Z9K1	-	psi-mi:stk25_human(display_long)|uniprotkb:STK25(gene name)|psi-mi:STK25(display_short)|uniprotkb:SOK1(gene name synonym)|uniprotkb:YSK1(gene name synonym)|uniprotkb:Sterile 20/oxidant stress-response kinase 1(gene name synonym)|uniprotkb:Ste20-like kinase(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1572946|imex:IM-19789-7	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000115694(gene)|ensembl:ENST00000316586(transcript)|ensembl:ENST00000401869(transcript)|ensembl:ENST00000403346(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035060|rcsb pdb:2XIK|rcsb pdb:3W8H|rcsb pdb:4NZW|refseq:NP_006365.2|refseq:NP_001258908.1|refseq:NP_001258909.1|refseq:NP_001269234.1|refseq:NP_001269237.1|refseq:NP_001269236.1|refseq:NP_001258906.1|refseq:NP_001258907.1|dip:DIP-34269N	-	go:"GO:0004672"(protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)	-	-	figure legend:Fig. 3A|resulting-ptm:Autophosphorylation of STK25|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/08	2014/10/16	rogid:yg5mghaePpT2LrC7wdG7xSGe0Pw9606	-	intact-crc:6183AC2BA704A58F	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	-
uniprotkb:Q9Y6E0	-	intact:EBI-740175|uniprotkb:O14840|ensembl:ENSP00000365730|uniprotkb:Q5JV92|intact:EBI-1054809	-	psi-mi:stk24_human(display_long)|uniprotkb:STK24(gene name)|psi-mi:STK24(display_short)|uniprotkb:MST3(gene name synonym)|uniprotkb:STK3(gene name synonym)|uniprotkb:STE20-like kinase MST3(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 3(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1572954|imex:IM-19789-8	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000102572(gene)|ensembl:ENST00000376547(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0045296"(cadherin binding)|refseq:NP_001027467.2|refseq:NP_003567.2|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3A7F|rcsb pdb:3A7G|rcsb pdb:3A7H|rcsb pdb:3A7I|rcsb pdb:3A7J|rcsb pdb:3CKW|rcsb pdb:3CKX|rcsb pdb:3ZHP|rcsb pdb:4O27|rcsb pdb:4QML|rcsb pdb:4QMM|rcsb pdb:4QMN|rcsb pdb:4QMO|rcsb pdb:4QMP|rcsb pdb:4QMQ|rcsb pdb:4QMS|rcsb pdb:4QMT|rcsb pdb:4QMU|rcsb pdb:4QMV|rcsb pdb:4QMW|rcsb pdb:4QMX|rcsb pdb:4QMY|rcsb pdb:4QMZ|rcsb pdb:4QNA|rcsb pdb:4QO9|rcsb pdb:4U8Z|rcsb pdb:4W8D|rcsb pdb:4W8E|rcsb pdb:7B30|rcsb pdb:7B31|rcsb pdb:7B32|rcsb pdb:7B33|rcsb pdb:7B34|rcsb pdb:7B35|reactome:R-HSA-111465|reactome:R-HSA-75153|dip:DIP-40608N	-	go:"GO:0004672"(protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)	-	-	figure legend:Fig. 3B|resulting-ptm:Autophosphorylation of STK24|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/08	2014/10/16	rogid:El6otOj/3rikTQX8EOIz3Eohgsw9606	-	intact-crc:4EA7DF7D9E8BBF37	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	-
uniprotkb:Q12923-4	uniprotkb:Q9BUL8	intact:EBI-355268|ensembl:ENSP00000394794|ensembl:ENSP00000426626	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	psi-mi:q12923-4(display_long)|uniprotkb:PTPN13(gene name)|psi-mi:PTPN13(display_short)|uniprotkb:PNP1(gene name synonym)|uniprotkb:PTP1E(gene name synonym)|uniprotkb:PTPL1(gene name synonym)|uniprotkb:Fas-associated protein-tyrosine phosphatase 1(gene name synonym)|uniprotkb:PTP-BAS(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1E(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase PTPL1(gene name synonym)	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1572972|imex:IM-19789-9	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-355227(ptn13_human)|ensembl:ENSG00000163629(gene)|ensembl:ENST00000436978(transcript)|ensembl:ENST00000511467(transcript)|uniprotkb:Q12923-4(isoform-parent)	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	go:"GO:0006470"(protein dephosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)	isoform-comment:May be due to a competing donor splice site.	-	figure legend:Fig. 3C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/08	2014/10/16	rogid:jqN+aJInF5s+MFrO7FTQRfg4vgE9606	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	intact-crc:A52C46569F251E9E|rigid:+5g2kmZZkGW2U4gb0VFViz7haoY	false	sufficient binding region:2091-2490(IPR000242)	O4'-phospho-L-tyrosine:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00506	uniprotkb:Q12923-4	intact:EBI-618295|ensembl:ENSP00000325748|ensembl:ENSP00000384162|ensembl:ENSP00000385687|uniprotkb:Q15522|uniprotkb:Q5BJF1|uniprotkb:A8K7D2|intact:EBI-5773834|uniprotkb:A8K6Z3|uniprotkb:B7Z9K1	intact:EBI-355268|ensembl:ENSP00000394794|ensembl:ENSP00000426626	psi-mi:stk25_human(display_long)|uniprotkb:STK25(gene name)|psi-mi:STK25(display_short)|uniprotkb:SOK1(gene name synonym)|uniprotkb:YSK1(gene name synonym)|uniprotkb:Sterile 20/oxidant stress-response kinase 1(gene name synonym)|uniprotkb:Ste20-like kinase(gene name synonym)	psi-mi:q12923-4(display_long)|uniprotkb:PTPN13(gene name)|psi-mi:PTPN13(display_short)|uniprotkb:PNP1(gene name synonym)|uniprotkb:PTP1E(gene name synonym)|uniprotkb:PTPL1(gene name synonym)|uniprotkb:Fas-associated protein-tyrosine phosphatase 1(gene name synonym)|uniprotkb:PTP-BAS(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1E(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase PTPL1(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1573011|imex:IM-19789-10	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115694(gene)|ensembl:ENST00000316586(transcript)|ensembl:ENST00000401869(transcript)|ensembl:ENST00000403346(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035060|rcsb pdb:2XIK|rcsb pdb:3W8H|rcsb pdb:4NZW|refseq:NP_006365.2|refseq:NP_001258908.1|refseq:NP_001258909.1|refseq:NP_001269234.1|refseq:NP_001269237.1|refseq:NP_001269236.1|refseq:NP_001258906.1|refseq:NP_001258907.1|dip:DIP-34269N	intact:EBI-355227(ptn13_human)|ensembl:ENSG00000163629(gene)|ensembl:ENST00000436978(transcript)|ensembl:ENST00000511467(transcript)|uniprotkb:Q12923-4(isoform-parent)	go:"GO:0006470"(protein dephosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)	-	isoform-comment:May be due to a competing donor splice site.	figure legend:Fig. 3C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/08	2014/10/16	rogid:yg5mghaePpT2LrC7wdG7xSGe0Pw9606	rogid:jqN+aJInF5s+MFrO7FTQRfg4vgE9606	intact-crc:AF93D48C92B531B1|rigid:/+tXLodqcje4ZdHeb0d2OC48YjY	false	O4'-phospho-L-tyrosine:?-?|glutathione s tranferase tag:?-?	sufficient binding region:2091-2490(IPR000242)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BSQ5	uniprotkb:Q9BUL8	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1573045|imex:IM-19789-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	-	-	-	delivery method:Q9BUL8; Q9BSQ5 transfection|figure legend:Figs. 4A and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/01/08	2014/10/16	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	intact-crc:80D8F3F1D8293F36|rigid:nMZbMKQ4LwY5uDFU0wuw9SgXzCI	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BSQ5	uniprotkb:O00522	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1573149|imex:IM-19789-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	-	-	-	delivery method:O00522; Q9BSQ5 transfection|figure legend:Fig. 4A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/01/08	2014/10/16	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	intact-crc:0D98BB21BD033F35|rigid:D4TuNCybE4z1XQ1ZZRgZbRz+9Mo	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BSQ5	uniprotkb:Q9BUL8	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1573204|imex:IM-19789-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	-	-	-	delivery method:Q9BUL8; Q9BSQ5 transfection|figure legend:Fig. 4D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/01/08	2014/10/16	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	intact-crc:49F43A53A2ECC579|rigid:nMZbMKQ4LwY5uDFU0wuw9SgXzCI	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00522	uniprotkb:Q9BSQ5	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1573214|imex:IM-19789-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N	-	-	-	delivery method:O00522; Q9BSQ5 transfection|figure legend:Fig. 4D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/01/08	2014/10/16	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	intact-crc:A16F2C8AFDA57A35|rigid:D4TuNCybE4z1XQ1ZZRgZbRz+9Mo	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00522	uniprotkb:Q9BUL8	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1573226|imex:IM-19789-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	-	-	-	delivery method:Q9BUL8; O00522; Q9BSQ5 transfection|figure legend:Fig. 4D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/01/08	2014/10/16	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	intact-crc:DDDF71E6F855B319|rigid:ZADI5bBg3AKKMmM306iOmLppzLQ	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00522	uniprotkb:Q9BSQ5	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1573226|imex:IM-19789-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N	-	-	-	delivery method:Q9BUL8; O00522; Q9BSQ5 transfection|figure legend:Fig. 4D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/01/08	2014/10/16	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	intact-crc:DDDF71E6F855B319|rigid:ZADI5bBg3AKKMmM306iOmLppzLQ	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00506	uniprotkb:Q9BSQ5	intact:EBI-618295|ensembl:ENSP00000325748|ensembl:ENSP00000384162|ensembl:ENSP00000385687|uniprotkb:Q15522|uniprotkb:Q5BJF1|uniprotkb:A8K7D2|intact:EBI-5773834|uniprotkb:A8K6Z3|uniprotkb:B7Z9K1	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	psi-mi:stk25_human(display_long)|uniprotkb:STK25(gene name)|psi-mi:STK25(display_short)|uniprotkb:SOK1(gene name synonym)|uniprotkb:YSK1(gene name synonym)|uniprotkb:Sterile 20/oxidant stress-response kinase 1(gene name synonym)|uniprotkb:Ste20-like kinase(gene name synonym)	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1573263|imex:IM-19789-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115694(gene)|ensembl:ENST00000316586(transcript)|ensembl:ENST00000401869(transcript)|ensembl:ENST00000403346(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035060|rcsb pdb:2XIK|rcsb pdb:3W8H|rcsb pdb:4NZW|refseq:NP_006365.2|refseq:NP_001258908.1|refseq:NP_001258909.1|refseq:NP_001269234.1|refseq:NP_001269237.1|refseq:NP_001269236.1|refseq:NP_001258906.1|refseq:NP_001258907.1|dip:DIP-34269N	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N	-	-	-	delivery method:O00506; Q9BSQ5 transfection|figure legend:Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/01/08	2014/10/16	rogid:yg5mghaePpT2LrC7wdG7xSGe0Pw9606	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	intact-crc:EA586C5E14D232E1|rigid:u+0ahcRZaMNOEydGdYIKFIk+a0U	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BSQ5	uniprotkb:Q9BUL8	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Voss et al. (2007)	pubmed:17657516|imex:IM-19789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1573185|imex:IM-19789-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	-	-	-	delivery method:Q9BUL8; Q9BSQ5 transfection|figure legend:Fig. 4C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/01/08	2014/10/16	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	intact-crc:46FC9890ECA34C41|rigid:nMZbMKQ4LwY5uDFU0wuw9SgXzCI	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)