#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P30153 uniprotkb:P63151 intact:EBI-302388|uniprotkb:Q13773|uniprotkb:Q6ICQ3|uniprotkb:Q96DH3|ensembl:ENSP00000324804 intact:EBI-1048931|uniprotkb:P50409|uniprotkb:Q00007|uniprotkb:B2RBU8|intact:EBI-2556013|uniprotkb:B4E1T7|ensembl:ENSP00000370113 psi-mi:2aaa_human(display_long)|uniprotkb:PPP2R1A(gene name)|psi-mi:PPP2R1A(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)|uniprotkb:Medium tumor antigen-associated 61 kDa protein(gene name synonym) psi-mi:2aba_human(display_long)|uniprotkb:PPP2R2A(gene name)|psi-mi:PPP2R2A(display_short)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Junttila et al. (2007) imex:IM-12065|pubmed:17632056 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1802422|imex:IM-12065-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000105568(gene)|ensembl:ENST00000322088(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990405"(protein antigen binding)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:P30153|rcsb pdb:1B3U|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:2PKG|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3K7V|rcsb pdb:3K7W|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6IUR|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2995383|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-8854518|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_055040.2|dip:DIP-29394N refseq:NP_001171062.1|refseq:NP_002708.1|ensembl:ENSG00000221914(gene)|ensembl:ENST00000380737(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:P63151|rcsb pdb:3DW8|reactome:R-HSA-2995383|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-975957|dip:DIP-29398N psi-mi:"MI:0469"(intact) - - comment:A catalytic subunit of PP2a was also identified but not as a specific gene product.|figure legend:Fig 1 B and Supp Table 1.|delivery method:P30153 transfection.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ht1080)|taxid:9606(Homo sapiens HT1080 fribrosarcoma cell line) - 2008/08/13 2014/10/16 rogid:73tR8yYYvViK8JdgIg18XWc3HRc9606 rogid:evS6klM2alZXtMthVsshKkrNgiA9606 intact-crc:AAA29451BE464777|rigid:JVX8l3NwcD5FBLxFDDwcux5JT+s false calmodulin binding peptide plus protein a tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:P30153 uniprotkb:Q8TCG1 intact:EBI-302388|uniprotkb:Q13773|uniprotkb:Q6ICQ3|uniprotkb:Q96DH3|ensembl:ENSP00000324804 intact:EBI-1379376|uniprotkb:B9EGC3|uniprotkb:A1L4J7|uniprotkb:Q6P4G6|uniprotkb:Q8WVP8|uniprotkb:Q96PI2|uniprotkb:Q9H9C6|uniprotkb:Q9P204|ensembl:ENSP00000295746 psi-mi:2aaa_human(display_long)|uniprotkb:PPP2R1A(gene name)|psi-mi:PPP2R1A(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)|uniprotkb:Medium tumor antigen-associated 61 kDa protein(gene name synonym) psi-mi:cip2a_human(display_long)|uniprotkb:CIP2A(gene name)|psi-mi:CIP2A(display_short)|uniprotkb:Cancerous inhibitor of PP2A(gene name synonym)|uniprotkb:KIAA1524(gene name synonym)|uniprotkb:p90 autoantigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Junttila et al. (2007) imex:IM-12065|pubmed:17632056 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1802422|imex:IM-12065-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000105568(gene)|ensembl:ENST00000322088(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990405"(protein antigen binding)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:P30153|rcsb pdb:1B3U|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:2PKG|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3K7V|rcsb pdb:3K7W|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6IUR|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2995383|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-8854518|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_055040.2|dip:DIP-29394N refseq:XP_006713780.1|refseq:NP_065941.2|refseq:XP_011511358.1|ensembl:ENSG00000163507(gene)|ensembl:ENST00000295746(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042510|rcsb pdb:5UFL psi-mi:"MI:0469"(intact) - - comment:A catalytic subunit of PP2a was also identified but not as a specific gene product.|figure legend:Fig 1 B and Supp Table 1.|delivery method:P30153 transfection.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ht1080)|taxid:9606(Homo sapiens HT1080 fribrosarcoma cell line) - 2008/08/13 2014/10/16 rogid:73tR8yYYvViK8JdgIg18XWc3HRc9606 rogid:L9bS1Ko7hMRa/pYXVI0Gvybco8s9606 intact-crc:AAA29451BE464777|rigid:JVX8l3NwcD5FBLxFDDwcux5JT+s false calmodulin binding peptide plus protein a tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:P30153 uniprotkb:Q8TCG1 intact:EBI-302388|uniprotkb:Q13773|uniprotkb:Q6ICQ3|uniprotkb:Q96DH3|ensembl:ENSP00000324804 intact:EBI-1379376|uniprotkb:B9EGC3|uniprotkb:A1L4J7|uniprotkb:Q6P4G6|uniprotkb:Q8WVP8|uniprotkb:Q96PI2|uniprotkb:Q9H9C6|uniprotkb:Q9P204|ensembl:ENSP00000295746 psi-mi:2aaa_human(display_long)|uniprotkb:PPP2R1A(gene name)|psi-mi:PPP2R1A(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)|uniprotkb:Medium tumor antigen-associated 61 kDa protein(gene name synonym) psi-mi:cip2a_human(display_long)|uniprotkb:CIP2A(gene name)|psi-mi:CIP2A(display_short)|uniprotkb:Cancerous inhibitor of PP2A(gene name synonym)|uniprotkb:KIAA1524(gene name synonym)|uniprotkb:p90 autoantigen(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Junttila et al. (2007) imex:IM-12065|pubmed:17632056 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1802445|imex:IM-12065-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000105568(gene)|ensembl:ENST00000322088(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990405"(protein antigen binding)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:P30153|rcsb pdb:1B3U|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:2PKG|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3K7V|rcsb pdb:3K7W|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6IUR|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2995383|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-8854518|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_055040.2|dip:DIP-29394N refseq:XP_006713780.1|refseq:NP_065941.2|refseq:XP_011511358.1|ensembl:ENSG00000163507(gene)|ensembl:ENST00000295746(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042510|rcsb pdb:5UFL psi-mi:"MI:0469"(intact) - - comment:A catalytic subunit of PP2a was also identified but not as a specific gene product.|figure legend:Fig 1 C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2008/08/13 2014/10/16 rogid:73tR8yYYvViK8JdgIg18XWc3HRc9606 rogid:L9bS1Ko7hMRa/pYXVI0Gvybco8s9606 intact-crc:45BF405E3762DE06|rigid:rr6WmUbW7sBI7+tJx3O5VHnfSTc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8TCG1 uniprotkb:P30153 intact:EBI-1379376|uniprotkb:B9EGC3|uniprotkb:A1L4J7|uniprotkb:Q6P4G6|uniprotkb:Q8WVP8|uniprotkb:Q96PI2|uniprotkb:Q9H9C6|uniprotkb:Q9P204|ensembl:ENSP00000295746 intact:EBI-302388|uniprotkb:Q13773|uniprotkb:Q6ICQ3|uniprotkb:Q96DH3|ensembl:ENSP00000324804 psi-mi:cip2a_human(display_long)|uniprotkb:CIP2A(gene name)|psi-mi:CIP2A(display_short)|uniprotkb:Cancerous inhibitor of PP2A(gene name synonym)|uniprotkb:KIAA1524(gene name synonym)|uniprotkb:p90 autoantigen(gene name synonym) psi-mi:2aaa_human(display_long)|uniprotkb:PPP2R1A(gene name)|psi-mi:PPP2R1A(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)|uniprotkb:Medium tumor antigen-associated 61 kDa protein(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Junttila et al. (2007) imex:IM-12065|pubmed:17632056 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1802463|imex:IM-12065-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006713780.1|refseq:NP_065941.2|refseq:XP_011511358.1|ensembl:ENSG00000163507(gene)|ensembl:ENST00000295746(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042510|rcsb pdb:5UFL ensembl:ENSG00000105568(gene)|ensembl:ENST00000322088(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990405"(protein antigen binding)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:P30153|rcsb pdb:1B3U|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:2PKG|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3K7V|rcsb pdb:3K7W|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6IUR|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2995383|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-8854518|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_055040.2|dip:DIP-29394N go:"GO:0005737"(cytoplasm)|go:"GO:0048471"(perinuclear region of cytoplasm) - - figure legend:Fig 1 D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2008/08/13 2014/10/16 rogid:L9bS1Ko7hMRa/pYXVI0Gvybco8s9606 rogid:73tR8yYYvViK8JdgIg18XWc3HRc9606 intact-crc:C9E72AA18DBCAFA7|rigid:rr6WmUbW7sBI7+tJx3O5VHnfSTc false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q8TCG1 uniprotkb:P30153 intact:EBI-1379376|uniprotkb:B9EGC3|uniprotkb:A1L4J7|uniprotkb:Q6P4G6|uniprotkb:Q8WVP8|uniprotkb:Q96PI2|uniprotkb:Q9H9C6|uniprotkb:Q9P204|ensembl:ENSP00000295746 intact:EBI-302388|uniprotkb:Q13773|uniprotkb:Q6ICQ3|uniprotkb:Q96DH3|ensembl:ENSP00000324804 psi-mi:cip2a_human(display_long)|uniprotkb:CIP2A(gene name)|psi-mi:CIP2A(display_short)|uniprotkb:Cancerous inhibitor of PP2A(gene name synonym)|uniprotkb:KIAA1524(gene name synonym)|uniprotkb:p90 autoantigen(gene name synonym) psi-mi:2aaa_human(display_long)|uniprotkb:PPP2R1A(gene name)|psi-mi:PPP2R1A(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)|uniprotkb:Medium tumor antigen-associated 61 kDa protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Junttila et al. (2007) imex:IM-12065|pubmed:17632056 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1802484|imex:IM-12065-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006713780.1|refseq:NP_065941.2|refseq:XP_011511358.1|ensembl:ENSG00000163507(gene)|ensembl:ENST00000295746(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042510|rcsb pdb:5UFL ensembl:ENSG00000105568(gene)|ensembl:ENST00000322088(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990405"(protein antigen binding)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:P30153|rcsb pdb:1B3U|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:2PKG|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3K7V|rcsb pdb:3K7W|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6IUR|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2995383|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-8854518|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_055040.2|dip:DIP-29394N psi-mi:"MI:0469"(intact) - - figure legend:Fig 1 E|delivery method:Q8TCG1 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2008/08/13 2014/10/16 rogid:L9bS1Ko7hMRa/pYXVI0Gvybco8s9606 rogid:73tR8yYYvViK8JdgIg18XWc3HRc9606 intact-crc:9C3BE3C88D9D332D|rigid:rr6WmUbW7sBI7+tJx3O5VHnfSTc false flag tag:?-?|sufficient binding region:461-533 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8TCG1 uniprotkb:P01106 intact:EBI-1379376|uniprotkb:B9EGC3|uniprotkb:A1L4J7|uniprotkb:Q6P4G6|uniprotkb:Q8WVP8|uniprotkb:Q96PI2|uniprotkb:Q9H9C6|uniprotkb:Q9P204|ensembl:ENSP00000295746 intact:EBI-447544|intact:EBI-1058440|uniprotkb:P01107|uniprotkb:Q14026|uniprotkb:A8WFE7|ensembl:ENSP00000367207|ensembl:ENSP00000499105 psi-mi:cip2a_human(display_long)|uniprotkb:CIP2A(gene name)|psi-mi:CIP2A(display_short)|uniprotkb:Cancerous inhibitor of PP2A(gene name synonym)|uniprotkb:KIAA1524(gene name synonym)|uniprotkb:p90 autoantigen(gene name synonym) psi-mi:myc_human(display_long)|uniprotkb:BHLHE39(gene name synonym)|uniprotkb:Transcription factor p64(gene name synonym)|uniprotkb:MYC(gene name)|psi-mi:MYC(display_short)|uniprotkb:Proto-oncogene c-Myc(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 39(gene name synonym) psi-mi:"MI:0096"(pull down) Junttila et al. (2007) imex:IM-12065|pubmed:17632056 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1802521|imex:IM-12065-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006713780.1|refseq:NP_065941.2|refseq:XP_011511358.1|ensembl:ENSG00000163507(gene)|ensembl:ENST00000295746(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042510|rcsb pdb:5UFL refseq:NP_002458.2|dip:DIP-28143N|ensembl:ENSG00000136997(gene)|ensembl:ENST00000377970(transcript)|ensembl:ENST00000652288(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035690"|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090096"(positive regulation of metanephric cap mesenchymal cell proliferation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904672"(regulation of somatic stem cell population maintenance)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR002418(Transcription regulator Myc)|interpro:IPR003327(Leucine zipper, Myc)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR012682(Transcription regulator Myc, N-terminal)|interpro:IPR036638|mint:P01106|rcsb pdb:1A93|rcsb pdb:1EE4|rcsb pdb:1MV0|rcsb pdb:1NKP|rcsb pdb:2A93|rcsb pdb:2OR9|rcsb pdb:4Y7R|rcsb pdb:5I4Z|rcsb pdb:5I50|rcsb pdb:6C4U|rcsb pdb:6E16|rcsb pdb:6E24|rcsb pdb:6G6J|rcsb pdb:6G6K|rcsb pdb:6G6L|reactome:R-HSA-1362277|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015671"(oxygen transport)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-4411364|reactome:R-HSA-5687128|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8866911|reactome:R-HSA-8951430|reactome:R-HSA-9018519|reactome:R-HSA-9616222 psi-mi:"MI:0469"(intact) - - figure legend:Fig 3D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/08/13 2014/10/16 rogid:L9bS1Ko7hMRa/pYXVI0Gvybco8s9606 rogid:CCk+p9FN7JV6cTmJDlin2hRp1tg9606 intact-crc:0FEFE51ECEDF8B6D|rigid:cmMlceVLWLeCiRgGFOx8trX+W1k false flag tag:?-? glutathione s tranferase tag:?-?|sufficient binding region:1-262 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8TCG1 uniprotkb:P01106 intact:EBI-1379376|uniprotkb:B9EGC3|uniprotkb:A1L4J7|uniprotkb:Q6P4G6|uniprotkb:Q8WVP8|uniprotkb:Q96PI2|uniprotkb:Q9H9C6|uniprotkb:Q9P204|ensembl:ENSP00000295746 intact:EBI-447544|intact:EBI-1058440|uniprotkb:P01107|uniprotkb:Q14026|uniprotkb:A8WFE7|ensembl:ENSP00000367207|ensembl:ENSP00000499105 psi-mi:cip2a_human(display_long)|uniprotkb:CIP2A(gene name)|psi-mi:CIP2A(display_short)|uniprotkb:Cancerous inhibitor of PP2A(gene name synonym)|uniprotkb:KIAA1524(gene name synonym)|uniprotkb:p90 autoantigen(gene name synonym) psi-mi:myc_human(display_long)|uniprotkb:BHLHE39(gene name synonym)|uniprotkb:Transcription factor p64(gene name synonym)|uniprotkb:MYC(gene name)|psi-mi:MYC(display_short)|uniprotkb:Proto-oncogene c-Myc(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 39(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Junttila et al. (2007) imex:IM-12065|pubmed:17632056 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1802544|imex:IM-12065-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006713780.1|refseq:NP_065941.2|refseq:XP_011511358.1|ensembl:ENSG00000163507(gene)|ensembl:ENST00000295746(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042510|rcsb pdb:5UFL refseq:NP_002458.2|dip:DIP-28143N|ensembl:ENSG00000136997(gene)|ensembl:ENST00000377970(transcript)|ensembl:ENST00000652288(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035690"|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090096"(positive regulation of metanephric cap mesenchymal cell proliferation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904672"(regulation of somatic stem cell population maintenance)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR002418(Transcription regulator Myc)|interpro:IPR003327(Leucine zipper, Myc)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR012682(Transcription regulator Myc, N-terminal)|interpro:IPR036638|mint:P01106|rcsb pdb:1A93|rcsb pdb:1EE4|rcsb pdb:1MV0|rcsb pdb:1NKP|rcsb pdb:2A93|rcsb pdb:2OR9|rcsb pdb:4Y7R|rcsb pdb:5I4Z|rcsb pdb:5I50|rcsb pdb:6C4U|rcsb pdb:6E16|rcsb pdb:6E24|rcsb pdb:6G6J|rcsb pdb:6G6K|rcsb pdb:6G6L|reactome:R-HSA-1362277|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015671"(oxygen transport)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-4411364|reactome:R-HSA-5687128|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8866911|reactome:R-HSA-8951430|reactome:R-HSA-9018519|reactome:R-HSA-9616222 psi-mi:"MI:0469"(intact) - - figure legend:Fig 3E, Supp. Fig. 3|delivery method:P01106; Q8TCG1 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2008/08/13 2014/10/16 rogid:L9bS1Ko7hMRa/pYXVI0Gvybco8s9606 rogid:CCk+p9FN7JV6cTmJDlin2hRp1tg9606 intact-crc:E1D72D5371E218E5|rigid:cmMlceVLWLeCiRgGFOx8trX+W1k false flag tag:?-? mutation decreasing interaction:62-62|his tag:?-?|mutation decreasing interaction:62-62|v5 tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)