#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P18384 uniprotkb:Q01218 intact:EBI-7366868|uniprotkb:Q76ZX8|intact:MINT-6740529 intact:EBI-7366886|uniprotkb:Q76ZM3|intact:MINT-6740514 psi-mi:spi3_vaccw(display_long)|uniprotkb:K2L(orf name)|uniprotkb:VACWR033(locus name)|uniprotkb:Serine proteinase inhibitor 3(gene name synonym)|uniprotkb:SPI-3(gene name)|psi-mi:SPI-3(display_short) psi-mi:hema_vaccw(display_long)|uniprotkb:A56R(orf name)|uniprotkb:VACWR181(locus name)|uniprotkb:Hemagglutinin(gene name synonym)|uniprotkb:HA(gene name)|psi-mi:HA(display_short) psi-mi:"MI:0676"(tandem affinity purification) Wagenaar et al. (2007) pubmed:17409143|mint:MINT-6665092 taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7366906|mint:MINT-6741013 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P18384|refseq:YP_232915.1|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023796|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR042178|interpro:IPR042185|interpro:IPR036186|mint:MINT-6741016(identity)|uniprotkb:P18384(P18384) mint:Q01218|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|refseq:YP_233063.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0033644"(host cell membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR036179|mint:MINT-6741014(identity)|uniprotkb:Q01218(Q01218) - function:May play a role in controlling cell-cell fusion|comment:mint comment:mint figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-3(unknown)|taxid:-3(Unknown) - 2008/07/28 2014/10/16 rogid:/UfQOAnFft1YHBHdJXHyWWia9nA10254 rogid:3la7s+8HpRZJ0qgl7DrN4qbd7gs10254 intact-crc:C833D774D7D444F8|rigid:B13XX7aA0/XxDkkx0gL+GHWvbtM false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07618 uniprotkb:Q01218 intact:EBI-7366976|intact:MINT-6740551 intact:EBI-7366886|uniprotkb:Q76ZM3|intact:MINT-6740514 psi-mi:j5_vaccw(display_long)|uniprotkb:J5L(orf name)|uniprotkb:VACWR097(locus name)|uniprotkb:Protein F11(gene name synonym) psi-mi:hema_vaccw(display_long)|uniprotkb:A56R(orf name)|uniprotkb:VACWR181(locus name)|uniprotkb:Hemagglutinin(gene name synonym)|uniprotkb:HA(gene name)|psi-mi:HA(display_short) psi-mi:"MI:0676"(tandem affinity purification) Wagenaar et al. (2007) pubmed:17409143|mint:MINT-6665092 taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7366992|mint:MINT-6741028 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P07618|interpro:IPR004251(Protein of unknown function DUF230, poxvirus)|refseq:YP_232979.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0055036"(virion membrane)|mint:MINT-6741029(identity)|uniprotkb:P07618(P07618) mint:Q01218|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|refseq:YP_233063.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0033644"(host cell membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR036179|mint:MINT-6741031(identity)|uniprotkb:Q01218(Q01218) - function:"Involved in virus entry into host cell and for cell-cell fusion (syncytium formation)"|comment:mint comment:mint figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-3(unknown)|taxid:-3(Unknown) - 2008/07/28 2014/10/16 rogid:fDCp1OgYXsFcfKpXBN10ioIQSh810254 rogid:3la7s+8HpRZJ0qgl7DrN4qbd7gs10254 intact-crc:FC250E18B4AB05AD|rigid:+opbPcfOA2b62B3X8mpLweNNDVM false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q01218 uniprotkb:P16710 intact:EBI-7366886|uniprotkb:Q76ZM3|intact:MINT-6740514 intact:EBI-7366919|uniprotkb:Q80HV5|intact:MINT-6740541 psi-mi:hema_vaccw(display_long)|uniprotkb:A56R(orf name)|uniprotkb:VACWR181(locus name)|uniprotkb:Hemagglutinin(gene name synonym)|uniprotkb:HA(gene name)|psi-mi:HA(display_short) psi-mi:a16_vaccw(display_long)|uniprotkb:A16L(orf name)|uniprotkb:VACWR136(locus name) psi-mi:"MI:0676"(tandem affinity purification) Wagenaar et al. (2007) pubmed:17409143|mint:MINT-6665092 taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7366935|mint:MINT-6741018 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q01218|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|refseq:YP_233063.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0033644"(host cell membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR036179|mint:MINT-6741021(identity)|uniprotkb:Q01218(Q01218) mint:P16710|interpro:IPR004251(Protein of unknown function DUF230, poxvirus)|refseq:YP_233018.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0039663"(membrane fusion involved in viral entry into host cell)|go:"GO:0055036"(virion membrane)|mint:MINT-6741019(identity)|uniprotkb:P16710(P16710) - comment:mint function:"Required for virus entry into host cell and for cell-cell fusion (syncytium formation)"|comment:mint figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-3(unknown)|taxid:-3(Unknown) - 2008/07/28 2014/10/16 rogid:3la7s+8HpRZJ0qgl7DrN4qbd7gs10254 rogid:0DTmz25GLePerPUe+dyac2+hldI10254 intact-crc:2A7D81A50EFAAA2D|rigid:FNk+F16QWNaTio1EqpmQwgvAam8 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07611 uniprotkb:Q01218 intact:EBI-6969213|intact:MINT-6740457|uniprotkb:Q76ZT8|uniprotkb:Q85328 intact:EBI-7366886|uniprotkb:Q76ZM3|intact:MINT-6740514 psi-mi:g9_vaccw(display_long)|uniprotkb:G9R(orf name)|uniprotkb:VACWR087(locus name)|uniprotkb:Protein F1(gene name synonym) psi-mi:hema_vaccw(display_long)|uniprotkb:A56R(orf name)|uniprotkb:VACWR181(locus name)|uniprotkb:Hemagglutinin(gene name synonym)|uniprotkb:HA(gene name)|psi-mi:HA(display_short) psi-mi:"MI:0676"(tandem affinity purification) Wagenaar et al. (2007) pubmed:17409143|mint:MINT-6665092 taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7366948|mint:MINT-6741023 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P07611|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR004251(Protein of unknown function DUF230, poxvirus)|refseq:YP_232969.1|mint:MINT-6741026(identity)|uniprotkb:P07611(P07611) mint:Q01218|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|refseq:YP_233063.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0033644"(host cell membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR036179|mint:MINT-6741024(identity)|uniprotkb:Q01218(Q01218) - function:"Involved in virus entry into host cell and for cell-cell fusion (syncytium formation)"|comment:mint comment:mint figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-3(unknown)|taxid:-3(Unknown) - 2008/07/28 2014/10/16 rogid:7dxgxS0RENJrVazdt8G2uwDCLnU10254 rogid:3la7s+8HpRZJ0qgl7DrN4qbd7gs10254 intact-crc:44E8BA4282F21B73|rigid:fMrtY1/jlJQbaVeExTz27Flts8A false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q01218 uniprotkb:P68638 intact:EBI-7366886|uniprotkb:Q76ZM3|intact:MINT-6740514 intact:EBI-7367059|intact:MINT-6740569|uniprotkb:Q76ZY4|uniprotkb:P10998 psi-mi:hema_vaccw(display_long)|uniprotkb:A56R(orf name)|uniprotkb:VACWR181(locus name)|uniprotkb:Hemagglutinin(gene name synonym)|uniprotkb:HA(gene name)|psi-mi:HA(display_short) psi-mi:vcp_vaccw(display_long)|uniprotkb:VACWR025(locus name)|uniprotkb:C3L(orf name)|uniprotkb:VCP(gene name synonym)|uniprotkb:Secretory protein 35(gene name synonym)|uniprotkb:28 kDa protein(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Wagenaar et al. (2007) pubmed:17409143|mint:MINT-6665092 taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7367052|mint:MINT-6741038 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q01218|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|refseq:YP_233063.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0033644"(host cell membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR036179|mint:MINT-6741041(identity)|uniprotkb:Q01218(Q01218) mint:P68638|refseq:YP_232907.1|interpro:IPR011176(Complement control protein, vaccinia C3L)|interpro:IPR000436(Sushi/SCR/CCP)|go:"GO:0001848"(complement binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039573"(suppression by virus of host complement activation)|go:"GO:0055036"(virion membrane)|go:"GO:0005576"(extracellular region)|rcsb pdb:1VVC|rcsb pdb:1VVD|rcsb pdb:1VVE|interpro:IPR035976|mint:MINT-6741039(identity)|uniprotkb:P68638(P68638) - comment:mint function:Serves to protect the virus against complement attack by inhibiting both classical and alternative pathways of complement activation. Binds C3b and C4b|comment:mint figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-3(unknown)|taxid:-3(Unknown) - 2008/07/28 2014/10/16 rogid:3la7s+8HpRZJ0qgl7DrN4qbd7gs10254 rogid:T5YJLU5uMrydUCbTjXeNgyIBHZM10254 intact-crc:AC13AA62BA00B764|rigid:tlU34WTTe1ia2Jaen5D/p1t1uoU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q01218 uniprotkb:P16714 intact:EBI-7366886|uniprotkb:Q76ZM3|intact:MINT-6740514 intact:EBI-7367012|uniprotkb:Q76ZV2|intact:MINT-6740559|uniprotkb:Q85324 psi-mi:hema_vaccw(display_long)|uniprotkb:A56R(orf name)|uniprotkb:VACWR181(locus name)|uniprotkb:Hemagglutinin(gene name synonym)|uniprotkb:HA(gene name)|psi-mi:HA(display_short) psi-mi:i1_vaccw(display_long)|uniprotkb:I1L(orf name)|uniprotkb:VACWR070(locus name) psi-mi:"MI:0676"(tandem affinity purification) Wagenaar et al. (2007) pubmed:17409143|mint:MINT-6665092 taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7367005|mint:MINT-6741033 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q01218|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|refseq:YP_233063.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0033644"(host cell membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR036179|mint:MINT-6741036(identity)|uniprotkb:Q01218(Q01218) mint:P16714|interpro:IPR004969(Poxvirus protein I1)|refseq:YP_232952.1|go:"GO:0003677"(DNA binding)|mint:MINT-6741034(identity)|uniprotkb:P16714(P16714) - comment:mint comment:mint figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-3(unknown)|taxid:-3(Unknown) - 2008/07/28 2014/10/16 rogid:3la7s+8HpRZJ0qgl7DrN4qbd7gs10254 rogid:TCN/uFrgwZu9j18dNMWynejMRH410254 intact-crc:9453650BFF772D2A|rigid:K3q+r/uGZUob/BI3XN9F8jC/RVY false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)