#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O15304	uniprotkb:P03129	intact:EBI-520756|uniprotkb:Q96P98|uniprotkb:Q9UPD6|ensembl:ENSP00000329213	intact:EBI-866453	psi-mi:siva_human(display_long)|uniprotkb:CD27-binding protein(gene name synonym)|uniprotkb:SIVA1(gene name)|psi-mi:SIVA1(display_short)|uniprotkb:SIVA(gene name synonym)	psi-mi:ve7_hpv16(display_long)|uniprotkb:E7(gene name)|psi-mi:E7(display_short)	psi-mi:"MI:0096"(pull down)	Severino et al. (2007)	pubmed:17348035|mint:MINT-6549831	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7317394|mint:MINT-6627979	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006418.2|refseq:NP_068355.1|ensembl:ENSG00000184990(gene)|ensembl:ENST00000329967(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005175"(CD27 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|interpro:IPR022773|mint:O15304|mint:MINT-6627982(identity)|uniprotkb:O15304(O15304)	refseq:NP_041326.1|dip:DIP-1090N|mint:P03129|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039560"(suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039650"(suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990216"(positive regulation by symbiont of host transcription)|interpro:IPR000148(Papillomavirus E7 protein)|rcsb pdb:4YOZ|rcsb pdb:6APN|mint:MINT-6627980(identity)|uniprotkb:P03129(P03129)	-	-	-	figure legend:F1 F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/06/26	2014/10/16	rogid:ZSaEOpu8SYAilgfYzcK/EGgUoiI9606	rogid:O1EL1sc/Ks4kPu1hY4hB3gQ26MM333760	intact-crc:10F88FCB8BBFCA95|rigid:1xxtVbaGaoPYQ08G51Y6hZLHf40	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03129	uniprotkb:O15304	intact:EBI-866453	intact:EBI-520756|uniprotkb:Q96P98|uniprotkb:Q9UPD6|ensembl:ENSP00000329213	psi-mi:ve7_hpv16(display_long)|uniprotkb:E7(gene name)|psi-mi:E7(display_short)	psi-mi:siva_human(display_long)|uniprotkb:CD27-binding protein(gene name synonym)|uniprotkb:SIVA1(gene name)|psi-mi:SIVA1(display_short)|uniprotkb:SIVA(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Severino et al. (2007)	pubmed:17348035|mint:MINT-6549831	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7317419|mint:MINT-6627986	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041326.1|dip:DIP-1090N|mint:P03129|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039560"(suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039650"(suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990216"(positive regulation by symbiont of host transcription)|interpro:IPR000148(Papillomavirus E7 protein)|rcsb pdb:4YOZ|rcsb pdb:6APN|mint:MINT-6627987(identity)|uniprotkb:P03129(P03129)	refseq:NP_006418.2|refseq:NP_068355.1|ensembl:ENSG00000184990(gene)|ensembl:ENST00000329967(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005175"(CD27 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|interpro:IPR022773|mint:O15304|mint:MINT-6627989(identity)|uniprotkb:O15304(O15304)	-	-	-	comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/06/26	2014/10/16	rogid:O1EL1sc/Ks4kPu1hY4hB3gQ26MM333760	rogid:ZSaEOpu8SYAilgfYzcK/EGgUoiI9606	intact-crc:23E2F4341C877C1D|rigid:1xxtVbaGaoPYQ08G51Y6hZLHf40	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03129	uniprotkb:O15304	intact:EBI-866453	intact:EBI-520756|uniprotkb:Q96P98|uniprotkb:Q9UPD6|ensembl:ENSP00000329213	psi-mi:ve7_hpv16(display_long)|uniprotkb:E7(gene name)|psi-mi:E7(display_short)	psi-mi:siva_human(display_long)|uniprotkb:CD27-binding protein(gene name synonym)|uniprotkb:SIVA1(gene name)|psi-mi:SIVA1(display_short)|uniprotkb:SIVA(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Severino et al. (2007)	pubmed:17348035|mint:MINT-6549831	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7317446|mint:MINT-6627993	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041326.1|dip:DIP-1090N|mint:P03129|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039560"(suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039650"(suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990216"(positive regulation by symbiont of host transcription)|interpro:IPR000148(Papillomavirus E7 protein)|rcsb pdb:4YOZ|rcsb pdb:6APN|mint:MINT-6627994(identity)|uniprotkb:P03129(P03129)	refseq:NP_006418.2|refseq:NP_068355.1|ensembl:ENSG00000184990(gene)|ensembl:ENST00000329967(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005175"(CD27 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|interpro:IPR022773|mint:O15304|mint:MINT-6627996(identity)|uniprotkb:O15304(O15304)	-	-	-	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/06/26	2014/10/16	rogid:O1EL1sc/Ks4kPu1hY4hB3gQ26MM333760	rogid:ZSaEOpu8SYAilgfYzcK/EGgUoiI9606	intact-crc:DBBC48825DB63987|rigid:1xxtVbaGaoPYQ08G51Y6hZLHf40	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03129	uniprotkb:O15304	intact:EBI-866453	intact:EBI-520756|uniprotkb:Q96P98|uniprotkb:Q9UPD6|ensembl:ENSP00000329213	psi-mi:ve7_hpv16(display_long)|uniprotkb:E7(gene name)|psi-mi:E7(display_short)	psi-mi:siva_human(display_long)|uniprotkb:CD27-binding protein(gene name synonym)|uniprotkb:SIVA1(gene name)|psi-mi:SIVA1(display_short)|uniprotkb:SIVA(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Severino et al. (2007)	pubmed:17348035|mint:MINT-6549831	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7317492|mint:MINT-6627998	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041326.1|dip:DIP-1090N|mint:P03129|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039560"(suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039650"(suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990216"(positive regulation by symbiont of host transcription)|interpro:IPR000148(Papillomavirus E7 protein)|rcsb pdb:4YOZ|rcsb pdb:6APN|mint:MINT-6627999(identity)|uniprotkb:P03129(P03129)	refseq:NP_006418.2|refseq:NP_068355.1|ensembl:ENSG00000184990(gene)|ensembl:ENST00000329967(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005175"(CD27 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|interpro:IPR022773|mint:O15304|mint:MINT-6628001(identity)|uniprotkb:O15304(O15304)	-	-	-	figure legend:F3|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/06/26	2014/10/16	rogid:O1EL1sc/Ks4kPu1hY4hB3gQ26MM333760	rogid:ZSaEOpu8SYAilgfYzcK/EGgUoiI9606	intact-crc:681D2E5518F2F67C|rigid:1xxtVbaGaoPYQ08G51Y6hZLHf40	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)