#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O00408	uniprotkb:O00170	intact:EBI-1785967|uniprotkb:B2R646|uniprotkb:B3KRV5|uniprotkb:Q5J791|uniprotkb:Q5J792|uniprotkb:Q6ZMR1|uniprotkb:E9PGI1|uniprotkb:Q5J793|uniprotkb:F6W5Z0|ensembl:ENSP00000334910	intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146	psi-mi:pde2a_human(display_long)|uniprotkb:PDE2A(gene name)|psi-mi:PDE2A(display_short)|uniprotkb:Cyclic GMP-stimulated phosphodiesterase(gene name synonym)	psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	de et al. (2007)	pubmed:17329248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1785989	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137311.1|refseq:NP_001139681.1|refseq:NP_002590.1|refseq:NP_001230713.1|dip:DIP-40269N|ensembl:ENSG00000186642(gene)|ensembl:ENST00000334456(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004118"(cGMP-stimulated cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030552"(cAMP binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0035690"|go:"GO:0035904"(aorta development)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:1904613"(cellular response to 2,3,7,8-tetrachlorodibenzodioxine)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR029016|interpro:IPR036971|rcsb pdb:1Z1L|rcsb pdb:3ITM|rcsb pdb:3ITU|rcsb pdb:4C1I|rcsb pdb:4D08|rcsb pdb:4D09|rcsb pdb:4HTX|rcsb pdb:4HTZ|rcsb pdb:4JIB|rcsb pdb:5TZ3|rcsb pdb:5TZA|rcsb pdb:5TZC|rcsb pdb:5TZH|rcsb pdb:5TZW|rcsb pdb:5TZX|rcsb pdb:5TZZ|rcsb pdb:5U00|rcsb pdb:5U7D|rcsb pdb:5U7I|rcsb pdb:5U7J|rcsb pdb:5U7K|rcsb pdb:5U7L|rcsb pdb:5VP0|rcsb pdb:5VP1|rcsb pdb:5XKM|rcsb pdb:6B96|rcsb pdb:6B97|rcsb pdb:6B98|rcsb pdb:6BLF|rcsb pdb:6C7D|rcsb pdb:6C7E|rcsb pdb:6C7F|rcsb pdb:6C7G|rcsb pdb:6C7I|rcsb pdb:6C7J|rcsb pdb:6CYB|rcsb pdb:6CYC|rcsb pdb:6CYD|rcsb pdb:6ZND|rcsb pdb:6ZQZ|reactome:R-HSA-418457|reactome:R-HSA-418555|rcsb pdb:3IBJ	refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/06/30	2014/10/16	rogid:vKnWkyeXHri0mNGezTw14HQyl6E9606	rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606	intact-crc:20902ACDE09CA27C|rigid:ZU+TCJna0o7J9Ly8lVoDPc/ft/8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O00408	uniprotkb:O00170	intact:EBI-1785967|uniprotkb:B2R646|uniprotkb:B3KRV5|uniprotkb:Q5J791|uniprotkb:Q5J792|uniprotkb:Q6ZMR1|uniprotkb:E9PGI1|uniprotkb:Q5J793|uniprotkb:F6W5Z0|ensembl:ENSP00000334910	intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146	psi-mi:pde2a_human(display_long)|uniprotkb:PDE2A(gene name)|psi-mi:PDE2A(display_short)|uniprotkb:Cyclic GMP-stimulated phosphodiesterase(gene name synonym)	psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	de et al. (2007)	pubmed:17329248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1786002	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137311.1|refseq:NP_001139681.1|refseq:NP_002590.1|refseq:NP_001230713.1|dip:DIP-40269N|ensembl:ENSG00000186642(gene)|ensembl:ENST00000334456(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004118"(cGMP-stimulated cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030552"(cAMP binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0035690"|go:"GO:0035904"(aorta development)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:1904613"(cellular response to 2,3,7,8-tetrachlorodibenzodioxine)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR029016|interpro:IPR036971|rcsb pdb:1Z1L|rcsb pdb:3ITM|rcsb pdb:3ITU|rcsb pdb:4C1I|rcsb pdb:4D08|rcsb pdb:4D09|rcsb pdb:4HTX|rcsb pdb:4HTZ|rcsb pdb:4JIB|rcsb pdb:5TZ3|rcsb pdb:5TZA|rcsb pdb:5TZC|rcsb pdb:5TZH|rcsb pdb:5TZW|rcsb pdb:5TZX|rcsb pdb:5TZZ|rcsb pdb:5U00|rcsb pdb:5U7D|rcsb pdb:5U7I|rcsb pdb:5U7J|rcsb pdb:5U7K|rcsb pdb:5U7L|rcsb pdb:5VP0|rcsb pdb:5VP1|rcsb pdb:5XKM|rcsb pdb:6B96|rcsb pdb:6B97|rcsb pdb:6B98|rcsb pdb:6BLF|rcsb pdb:6C7D|rcsb pdb:6C7E|rcsb pdb:6C7F|rcsb pdb:6C7G|rcsb pdb:6C7I|rcsb pdb:6C7J|rcsb pdb:6CYB|rcsb pdb:6CYC|rcsb pdb:6CYD|rcsb pdb:6ZND|rcsb pdb:6ZQZ|reactome:R-HSA-418457|reactome:R-HSA-418555|rcsb pdb:3IBJ	refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/06/30	2014/10/16	rogid:vKnWkyeXHri0mNGezTw14HQyl6E9606	rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606	intact-crc:75A719AC26BDBDAD|rigid:ZU+TCJna0o7J9Ly8lVoDPc/ft/8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00170	uniprotkb:O00408	intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146	intact:EBI-1785967|uniprotkb:B2R646|uniprotkb:B3KRV5|uniprotkb:Q5J791|uniprotkb:Q5J792|uniprotkb:Q6ZMR1|uniprotkb:E9PGI1|uniprotkb:Q5J793|uniprotkb:F6W5Z0|ensembl:ENSP00000334910	psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym)	psi-mi:pde2a_human(display_long)|uniprotkb:PDE2A(gene name)|psi-mi:PDE2A(display_short)|uniprotkb:Cyclic GMP-stimulated phosphodiesterase(gene name synonym)	psi-mi:"MI:0096"(pull down)	de et al. (2007)	pubmed:17329248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1786013	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505	refseq:NP_001137311.1|refseq:NP_001139681.1|refseq:NP_002590.1|refseq:NP_001230713.1|dip:DIP-40269N|ensembl:ENSG00000186642(gene)|ensembl:ENST00000334456(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004118"(cGMP-stimulated cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030552"(cAMP binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0035690"|go:"GO:0035904"(aorta development)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:1904613"(cellular response to 2,3,7,8-tetrachlorodibenzodioxine)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR029016|interpro:IPR036971|rcsb pdb:1Z1L|rcsb pdb:3ITM|rcsb pdb:3ITU|rcsb pdb:4C1I|rcsb pdb:4D08|rcsb pdb:4D09|rcsb pdb:4HTX|rcsb pdb:4HTZ|rcsb pdb:4JIB|rcsb pdb:5TZ3|rcsb pdb:5TZA|rcsb pdb:5TZC|rcsb pdb:5TZH|rcsb pdb:5TZW|rcsb pdb:5TZX|rcsb pdb:5TZZ|rcsb pdb:5U00|rcsb pdb:5U7D|rcsb pdb:5U7I|rcsb pdb:5U7J|rcsb pdb:5U7K|rcsb pdb:5U7L|rcsb pdb:5VP0|rcsb pdb:5VP1|rcsb pdb:5XKM|rcsb pdb:6B96|rcsb pdb:6B97|rcsb pdb:6B98|rcsb pdb:6BLF|rcsb pdb:6C7D|rcsb pdb:6C7E|rcsb pdb:6C7F|rcsb pdb:6C7G|rcsb pdb:6C7I|rcsb pdb:6C7J|rcsb pdb:6CYB|rcsb pdb:6CYC|rcsb pdb:6CYD|rcsb pdb:6ZND|rcsb pdb:6ZQZ|reactome:R-HSA-418457|reactome:R-HSA-418555|rcsb pdb:3IBJ	-	-	-	figure legend:1 B, 3|comment:"The authors conclude that the PDE2A GAF-2 domain is necessary and sufficient for AIP (XAP2) binding."	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/30	2014/10/16	rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606	rogid:vKnWkyeXHri0mNGezTw14HQyl6E9606	intact-crc:66B51F98E7E3B903|rigid:ZU+TCJna0o7J9Ly8lVoDPc/ft/8	false	glutathione s tranferase tag:?-?	sufficient binding region:379-650(IPR003018)|vsv tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00408	uniprotkb:O00170	intact:EBI-1785967|uniprotkb:B2R646|uniprotkb:B3KRV5|uniprotkb:Q5J791|uniprotkb:Q5J792|uniprotkb:Q6ZMR1|uniprotkb:E9PGI1|uniprotkb:Q5J793|uniprotkb:F6W5Z0|ensembl:ENSP00000334910	intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146	psi-mi:pde2a_human(display_long)|uniprotkb:PDE2A(gene name)|psi-mi:PDE2A(display_short)|uniprotkb:Cyclic GMP-stimulated phosphodiesterase(gene name synonym)	psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	de et al. (2007)	pubmed:17329248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1786164	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137311.1|refseq:NP_001139681.1|refseq:NP_002590.1|refseq:NP_001230713.1|dip:DIP-40269N|ensembl:ENSG00000186642(gene)|ensembl:ENST00000334456(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004118"(cGMP-stimulated cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030552"(cAMP binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0035690"|go:"GO:0035904"(aorta development)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:1904613"(cellular response to 2,3,7,8-tetrachlorodibenzodioxine)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR029016|interpro:IPR036971|rcsb pdb:1Z1L|rcsb pdb:3ITM|rcsb pdb:3ITU|rcsb pdb:4C1I|rcsb pdb:4D08|rcsb pdb:4D09|rcsb pdb:4HTX|rcsb pdb:4HTZ|rcsb pdb:4JIB|rcsb pdb:5TZ3|rcsb pdb:5TZA|rcsb pdb:5TZC|rcsb pdb:5TZH|rcsb pdb:5TZW|rcsb pdb:5TZX|rcsb pdb:5TZZ|rcsb pdb:5U00|rcsb pdb:5U7D|rcsb pdb:5U7I|rcsb pdb:5U7J|rcsb pdb:5U7K|rcsb pdb:5U7L|rcsb pdb:5VP0|rcsb pdb:5VP1|rcsb pdb:5XKM|rcsb pdb:6B96|rcsb pdb:6B97|rcsb pdb:6B98|rcsb pdb:6BLF|rcsb pdb:6C7D|rcsb pdb:6C7E|rcsb pdb:6C7F|rcsb pdb:6C7G|rcsb pdb:6C7I|rcsb pdb:6C7J|rcsb pdb:6CYB|rcsb pdb:6CYC|rcsb pdb:6CYD|rcsb pdb:6ZND|rcsb pdb:6ZQZ|reactome:R-HSA-418457|reactome:R-HSA-418555|rcsb pdb:3IBJ	refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505	-	-	-	figure legend:4	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/30	2014/10/16	rogid:vKnWkyeXHri0mNGezTw14HQyl6E9606	rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606	intact-crc:A02A3D09C8323385|rigid:ZU+TCJna0o7J9Ly8lVoDPc/ft/8	false	vsv tag:?-?	glutathione s tranferase tag:?-?|necessary binding region:170-330(IPR013026)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00170	uniprotkb:O00408	intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146	intact:EBI-1785967|uniprotkb:B2R646|uniprotkb:B3KRV5|uniprotkb:Q5J791|uniprotkb:Q5J792|uniprotkb:Q6ZMR1|uniprotkb:E9PGI1|uniprotkb:Q5J793|uniprotkb:F6W5Z0|ensembl:ENSP00000334910	psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym)	psi-mi:pde2a_human(display_long)|uniprotkb:PDE2A(gene name)|psi-mi:PDE2A(display_short)|uniprotkb:Cyclic GMP-stimulated phosphodiesterase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	de et al. (2007)	pubmed:17329248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1786029	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505	refseq:NP_001137311.1|refseq:NP_001139681.1|refseq:NP_002590.1|refseq:NP_001230713.1|dip:DIP-40269N|ensembl:ENSG00000186642(gene)|ensembl:ENST00000334456(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004118"(cGMP-stimulated cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030552"(cAMP binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0035690"|go:"GO:0035904"(aorta development)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:1904613"(cellular response to 2,3,7,8-tetrachlorodibenzodioxine)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR029016|interpro:IPR036971|rcsb pdb:1Z1L|rcsb pdb:3ITM|rcsb pdb:3ITU|rcsb pdb:4C1I|rcsb pdb:4D08|rcsb pdb:4D09|rcsb pdb:4HTX|rcsb pdb:4HTZ|rcsb pdb:4JIB|rcsb pdb:5TZ3|rcsb pdb:5TZA|rcsb pdb:5TZC|rcsb pdb:5TZH|rcsb pdb:5TZW|rcsb pdb:5TZX|rcsb pdb:5TZZ|rcsb pdb:5U00|rcsb pdb:5U7D|rcsb pdb:5U7I|rcsb pdb:5U7J|rcsb pdb:5U7K|rcsb pdb:5U7L|rcsb pdb:5VP0|rcsb pdb:5VP1|rcsb pdb:5XKM|rcsb pdb:6B96|rcsb pdb:6B97|rcsb pdb:6B98|rcsb pdb:6BLF|rcsb pdb:6C7D|rcsb pdb:6C7E|rcsb pdb:6C7F|rcsb pdb:6C7G|rcsb pdb:6C7I|rcsb pdb:6C7J|rcsb pdb:6CYB|rcsb pdb:6CYC|rcsb pdb:6CYD|rcsb pdb:6ZND|rcsb pdb:6ZQZ|reactome:R-HSA-418457|reactome:R-HSA-418555|rcsb pdb:3IBJ	-	-	-	figure legend:1 C|delivery method:O00408; O00170 transfection	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2008/06/30	2014/10/16	rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606	rogid:vKnWkyeXHri0mNGezTw14HQyl6E9606	intact-crc:FDE93B4E5BE35D3C|rigid:ZU+TCJna0o7J9Ly8lVoDPc/ft/8	false	flag tag:n-n	vsv tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q01062	uniprotkb:Q5FWY5	intact:EBI-1786062	intact:EBI-1786045|uniprotkb:Q8CGW7|ensembl:ENSRNOP00000000599|ensembl:ENSRNOP00000075162	psi-mi:pde2a_rat(display_long)|uniprotkb:Pde2a(gene name)|psi-mi:Pde2a(display_short)|uniprotkb:Cyclic GMP-stimulated phosphodiesterase(gene name synonym)	psi-mi:aip_rat(display_long)|uniprotkb:Aip(gene name)|psi-mi:Aip(display_short)|uniprotkb:Xap2(gene name synonym)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin XAP2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	de et al. (2007)	pubmed:17329248	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1786060	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029016|rgd:620965|refseq:NP_001137319.1|refseq:NP_112341.1|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR023174|interpro:IPR036971|reactome:R-RNO-418457|reactome:R-RNO-418555|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004118"(cGMP-stimulated cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010749"(regulation of nitric oxide mediated signal transduction)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0035904"(aorta development)|go:"GO:0036004"(GAF domain binding)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045121"(membrane raft)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:1904613"(cellular response to 2,3,7,8-tetrachlorodibenzodioxine)|go:"GO:1904880"(response to hydrogen sulfide)	rgd:628619|refseq:NP_758830.2|refseq:XP_006230761.1|refseq:XP_006230762.1|ensembl:ENSRNOG00000022289(gene)|ensembl:ENSRNOT00000000599(transcript)|ensembl:ENSRNOT00000091542(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|reactome:R-RNO-8937144	-	-	-	figure legend:1 D	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2008/06/30	2014/10/16	rogid:X2o8pXtpBScRaJ3Pi51U/sWS2LU10116	rogid:dLvzBpRDi9dVu4hGFzIWQ8ZWf5g10116	intact-crc:26A2AE2FCD82E8F8|rigid:kLEpObOcp54sfpjhzByTZCCEkZs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01062	uniprotkb:Q5FWY5	intact:EBI-1786062	intact:EBI-1786045|uniprotkb:Q8CGW7|ensembl:ENSRNOP00000000599|ensembl:ENSRNOP00000075162	psi-mi:pde2a_rat(display_long)|uniprotkb:Pde2a(gene name)|psi-mi:Pde2a(display_short)|uniprotkb:Cyclic GMP-stimulated phosphodiesterase(gene name synonym)	psi-mi:aip_rat(display_long)|uniprotkb:Aip(gene name)|psi-mi:Aip(display_short)|uniprotkb:Xap2(gene name synonym)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin XAP2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	de et al. (2007)	pubmed:17329248	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1786088	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029016|rgd:620965|refseq:NP_001137319.1|refseq:NP_112341.1|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR023174|interpro:IPR036971|reactome:R-RNO-418457|reactome:R-RNO-418555|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004118"(cGMP-stimulated cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010749"(regulation of nitric oxide mediated signal transduction)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0035904"(aorta development)|go:"GO:0036004"(GAF domain binding)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045121"(membrane raft)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:1904613"(cellular response to 2,3,7,8-tetrachlorodibenzodioxine)|go:"GO:1904880"(response to hydrogen sulfide)	rgd:628619|refseq:NP_758830.2|refseq:XP_006230761.1|refseq:XP_006230762.1|ensembl:ENSRNOG00000022289(gene)|ensembl:ENSRNOT00000000599(transcript)|ensembl:ENSRNOT00000091542(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|reactome:R-RNO-8937144	-	-	-	figure legend:1 D	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2008/06/30	2014/10/16	rogid:X2o8pXtpBScRaJ3Pi51U/sWS2LU10116	rogid:dLvzBpRDi9dVu4hGFzIWQ8ZWf5g10116	intact-crc:11B86560300D3E93|rigid:kLEpObOcp54sfpjhzByTZCCEkZs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00170	uniprotkb:O00408	intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146	intact:EBI-1785967|uniprotkb:B2R646|uniprotkb:B3KRV5|uniprotkb:Q5J791|uniprotkb:Q5J792|uniprotkb:Q6ZMR1|uniprotkb:E9PGI1|uniprotkb:Q5J793|uniprotkb:F6W5Z0|ensembl:ENSP00000334910	psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym)	psi-mi:pde2a_human(display_long)|uniprotkb:PDE2A(gene name)|psi-mi:PDE2A(display_short)|uniprotkb:Cyclic GMP-stimulated phosphodiesterase(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	de et al. (2007)	pubmed:17329248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1786110	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505	refseq:NP_001137311.1|refseq:NP_001139681.1|refseq:NP_002590.1|refseq:NP_001230713.1|dip:DIP-40269N|ensembl:ENSG00000186642(gene)|ensembl:ENST00000334456(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004118"(cGMP-stimulated cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030552"(cAMP binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0035690"|go:"GO:0035904"(aorta development)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:1904613"(cellular response to 2,3,7,8-tetrachlorodibenzodioxine)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR029016|interpro:IPR036971|rcsb pdb:1Z1L|rcsb pdb:3ITM|rcsb pdb:3ITU|rcsb pdb:4C1I|rcsb pdb:4D08|rcsb pdb:4D09|rcsb pdb:4HTX|rcsb pdb:4HTZ|rcsb pdb:4JIB|rcsb pdb:5TZ3|rcsb pdb:5TZA|rcsb pdb:5TZC|rcsb pdb:5TZH|rcsb pdb:5TZW|rcsb pdb:5TZX|rcsb pdb:5TZZ|rcsb pdb:5U00|rcsb pdb:5U7D|rcsb pdb:5U7I|rcsb pdb:5U7J|rcsb pdb:5U7K|rcsb pdb:5U7L|rcsb pdb:5VP0|rcsb pdb:5VP1|rcsb pdb:5XKM|rcsb pdb:6B96|rcsb pdb:6B97|rcsb pdb:6B98|rcsb pdb:6BLF|rcsb pdb:6C7D|rcsb pdb:6C7E|rcsb pdb:6C7F|rcsb pdb:6C7G|rcsb pdb:6C7I|rcsb pdb:6C7J|rcsb pdb:6CYB|rcsb pdb:6CYC|rcsb pdb:6CYD|rcsb pdb:6ZND|rcsb pdb:6ZQZ|reactome:R-HSA-418457|reactome:R-HSA-418555|rcsb pdb:3IBJ	go:"GO:0005737"(cytoplasm)	-	-	figure legend:2	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/06/30	2014/10/16	rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606	rogid:vKnWkyeXHri0mNGezTw14HQyl6E9606	intact-crc:C246B49664B2CFBC|rigid:ZU+TCJna0o7J9Ly8lVoDPc/ft/8	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
chebi:"CHEBI:17489"	uniprotkb:O00408	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1785967|uniprotkb:B2R646|uniprotkb:B3KRV5|uniprotkb:Q5J791|uniprotkb:Q5J792|uniprotkb:Q6ZMR1|uniprotkb:E9PGI1|uniprotkb:Q5J793|uniprotkb:F6W5Z0|ensembl:ENSP00000334910	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:pde2a_human(display_long)|uniprotkb:PDE2A(gene name)|psi-mi:PDE2A(display_short)|uniprotkb:Cyclic GMP-stimulated phosphodiesterase(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	de et al. (2007)	pubmed:17329248	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1786218	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001137311.1|refseq:NP_001139681.1|refseq:NP_002590.1|refseq:NP_001230713.1|dip:DIP-40269N|ensembl:ENSG00000186642(gene)|ensembl:ENST00000334456(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004118"(cGMP-stimulated cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030552"(cAMP binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0035690"|go:"GO:0035904"(aorta development)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:1904613"(cellular response to 2,3,7,8-tetrachlorodibenzodioxine)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR029016|interpro:IPR036971|rcsb pdb:1Z1L|rcsb pdb:3ITM|rcsb pdb:3ITU|rcsb pdb:4C1I|rcsb pdb:4D08|rcsb pdb:4D09|rcsb pdb:4HTX|rcsb pdb:4HTZ|rcsb pdb:4JIB|rcsb pdb:5TZ3|rcsb pdb:5TZA|rcsb pdb:5TZC|rcsb pdb:5TZH|rcsb pdb:5TZW|rcsb pdb:5TZX|rcsb pdb:5TZZ|rcsb pdb:5U00|rcsb pdb:5U7D|rcsb pdb:5U7I|rcsb pdb:5U7J|rcsb pdb:5U7K|rcsb pdb:5U7L|rcsb pdb:5VP0|rcsb pdb:5VP1|rcsb pdb:5XKM|rcsb pdb:6B96|rcsb pdb:6B97|rcsb pdb:6B98|rcsb pdb:6BLF|rcsb pdb:6C7D|rcsb pdb:6C7E|rcsb pdb:6C7F|rcsb pdb:6C7G|rcsb pdb:6C7I|rcsb pdb:6C7J|rcsb pdb:6CYB|rcsb pdb:6CYC|rcsb pdb:6CYD|rcsb pdb:6ZND|rcsb pdb:6ZQZ|reactome:R-HSA-418457|reactome:R-HSA-418555|rcsb pdb:3IBJ	go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)	-	-	figure legend:5 B|comment:"Catalytic activity of PDE2A was not affected by the presence or absence of AIP (XAP2).  The authors conclude that XAP2 interacting with PDE2A does not affect PDE2A catalytic capacity."	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/30	2014/10/16	-	rogid:vKnWkyeXHri0mNGezTw14HQyl6E9606	intact-crc:87FCF1DCC4D51BCC	false	-	vsv tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)