#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P21757	uniprotkb:Q7TQ77	intact:EBI-1776976|uniprotkb:P21759|uniprotkb:Q45F10|uniprotkb:O60505|uniprotkb:D3DSP3|ensembl:ENSP00000262101	intact:EBI-1777000|ensembl:ENSRNOP00000019281	psi-mi:msre_human(display_long)|uniprotkb:MSR1(gene name)|psi-mi:MSR1(display_short)|uniprotkb:SCARA1(gene name synonym)|uniprotkb:Macrophage acetylated LDL receptor I and II(gene name synonym)|uniprotkb:Scavenger receptor class A member 1(gene name synonym)	psi-mi:q7tq77_rat(display_long)	psi-mi:"MI:0018"(two hybrid)	Sano et al. (2007)	pubmed:17237231|imex:IM-19810	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1776975|imex:IM-19810-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002436.1|refseq:NP_619729.1|refseq:NP_619730.1|ensembl:ENSG00000038945(gene)|ensembl:ENST00000262101(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097242"(amyloid-beta clearance)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR003543(Macrophage scavenger receptor)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|mint:P21757|reactome:R-HSA-3000480	ensembl:ENSRNOG00000014275(gene)|ensembl:ENSRNOT00000019281(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0030897"(HOPS complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0034452"(dynactin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051645"(Golgi localization)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR008636(HOOK)	-	-	-	author-identifiers:PREY gene AY310154|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/05/27	2014/10/16	rogid:4IGV7T0fw+Y2rwPdICqixuiOM809606	rogid:yNkjg86zLTX6cQhwoRwVYxoN7oE10116	intact-crc:3DF12917900FBCDA|rigid:2rSwPNmifVzyHA4RLJ0zQWfGzxo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7TQ77	uniprotkb:P21757	intact:EBI-1777000|ensembl:ENSRNOP00000019281	intact:EBI-1776976|uniprotkb:P21759|uniprotkb:Q45F10|uniprotkb:O60505|uniprotkb:D3DSP3|ensembl:ENSP00000262101	psi-mi:q7tq77_rat(display_long)	psi-mi:msre_human(display_long)|uniprotkb:MSR1(gene name)|psi-mi:MSR1(display_short)|uniprotkb:SCARA1(gene name synonym)|uniprotkb:Macrophage acetylated LDL receptor I and II(gene name synonym)|uniprotkb:Scavenger receptor class A member 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Sano et al. (2007)	pubmed:17237231|imex:IM-19810	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1777020|imex:IM-19810-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000014275(gene)|ensembl:ENSRNOT00000019281(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0030897"(HOPS complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0034452"(dynactin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051645"(Golgi localization)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR008636(HOOK)	refseq:NP_002436.1|refseq:NP_619729.1|refseq:NP_619730.1|ensembl:ENSG00000038945(gene)|ensembl:ENST00000262101(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097242"(amyloid-beta clearance)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR003543(Macrophage scavenger receptor)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|mint:P21757|reactome:R-HSA-3000480	-	-	-	author-identifiers:PREY gene AY310154|figure legend:1 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/27	2014/10/16	rogid:yNkjg86zLTX6cQhwoRwVYxoN7oE10116	rogid:4IGV7T0fw+Y2rwPdICqixuiOM809606	intact-crc:F72D902E84C3F57A|rigid:2rSwPNmifVzyHA4RLJ0zQWfGzxo	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P21757	uniprotkb:Q86VS8	intact:EBI-1776976|uniprotkb:P21759|uniprotkb:Q45F10|uniprotkb:O60505|uniprotkb:D3DSP3|ensembl:ENSP00000262101	intact:EBI-1777078|uniprotkb:Q8NBH0|uniprotkb:Q9BY13|uniprotkb:D3DSY8|ensembl:ENSP00000305699	psi-mi:msre_human(display_long)|uniprotkb:MSR1(gene name)|psi-mi:MSR1(display_short)|uniprotkb:SCARA1(gene name synonym)|uniprotkb:Macrophage acetylated LDL receptor I and II(gene name synonym)|uniprotkb:Scavenger receptor class A member 1(gene name synonym)	psi-mi:hook3_human(display_long)|uniprotkb:HOOK3(gene name)|psi-mi:HOOK3(display_short)	psi-mi:"MI:0096"(pull down)	Sano et al. (2007)	pubmed:17237231|imex:IM-19810	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1777090|imex:IM-19810-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002436.1|refseq:NP_619729.1|refseq:NP_619730.1|ensembl:ENSG00000038945(gene)|ensembl:ENST00000262101(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097242"(amyloid-beta clearance)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR003543(Macrophage scavenger receptor)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|mint:P21757|reactome:R-HSA-3000480	refseq:NP_115786.1|ensembl:ENSG00000168172(gene)|ensembl:ENST00000307602(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR008636(HOOK)|interpro:IPR036872|interpro:IPR043936|rcsb pdb:5J8E|rcsb pdb:6B9H|go:"GO:0034454"(microtubule anchoring at centrosome)	-	-	-	figure legend:2 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/27	2014/10/16	rogid:4IGV7T0fw+Y2rwPdICqixuiOM809606	rogid:hzM38dyr89rY7z71px9K4rVNL6s9606	intact-crc:FEDDD8EA336C0B47|rigid:TzwAJeGv35d4GSIx0QYGVYoTGYc	false	necessary binding region:12-24|glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P21757	uniprotkb:Q86VS8	intact:EBI-1776976|uniprotkb:P21759|uniprotkb:Q45F10|uniprotkb:O60505|uniprotkb:D3DSP3|ensembl:ENSP00000262101	intact:EBI-1777078|uniprotkb:Q8NBH0|uniprotkb:Q9BY13|uniprotkb:D3DSY8|ensembl:ENSP00000305699	psi-mi:msre_human(display_long)|uniprotkb:MSR1(gene name)|psi-mi:MSR1(display_short)|uniprotkb:SCARA1(gene name synonym)|uniprotkb:Macrophage acetylated LDL receptor I and II(gene name synonym)|uniprotkb:Scavenger receptor class A member 1(gene name synonym)	psi-mi:hook3_human(display_long)|uniprotkb:HOOK3(gene name)|psi-mi:HOOK3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sano et al. (2007)	pubmed:17237231|imex:IM-19810	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1777111|imex:IM-19810-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002436.1|refseq:NP_619729.1|refseq:NP_619730.1|ensembl:ENSG00000038945(gene)|ensembl:ENST00000262101(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097242"(amyloid-beta clearance)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR003543(Macrophage scavenger receptor)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|mint:P21757|reactome:R-HSA-3000480	refseq:NP_115786.1|ensembl:ENSG00000168172(gene)|ensembl:ENST00000307602(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR008636(HOOK)|interpro:IPR036872|interpro:IPR043936|rcsb pdb:5J8E|rcsb pdb:6B9H|go:"GO:0034454"(microtubule anchoring at centrosome)	-	-	-	figure legend:2 C|comment:The negatively charged residues GLu12, Asp13 and Asp15 of SR-A may be essential for binding to Hook3.|delivery method:O60505 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/05/27	2014/10/16	rogid:4IGV7T0fw+Y2rwPdICqixuiOM809606	rogid:hzM38dyr89rY7z71px9K4rVNL6s9606	intact-crc:6B77A082206ADE7A|rigid:TzwAJeGv35d4GSIx0QYGVYoTGYc	false	necessary binding region:1-24|v5 tag:c-c|mutation disrupting interaction:12-12,13-13,15-15	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P21757	uniprotkb:Q86VS8	intact:EBI-1776976|uniprotkb:P21759|uniprotkb:Q45F10|uniprotkb:O60505|uniprotkb:D3DSP3|ensembl:ENSP00000262101	intact:EBI-1777078|uniprotkb:Q8NBH0|uniprotkb:Q9BY13|uniprotkb:D3DSY8|ensembl:ENSP00000305699	psi-mi:msre_human(display_long)|uniprotkb:MSR1(gene name)|psi-mi:MSR1(display_short)|uniprotkb:SCARA1(gene name synonym)|uniprotkb:Macrophage acetylated LDL receptor I and II(gene name synonym)|uniprotkb:Scavenger receptor class A member 1(gene name synonym)	psi-mi:hook3_human(display_long)|uniprotkb:HOOK3(gene name)|psi-mi:HOOK3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sano et al. (2007)	pubmed:17237231|imex:IM-19810	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1777151|imex:IM-19810-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002436.1|refseq:NP_619729.1|refseq:NP_619730.1|ensembl:ENSG00000038945(gene)|ensembl:ENST00000262101(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097242"(amyloid-beta clearance)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR003543(Macrophage scavenger receptor)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|mint:P21757|reactome:R-HSA-3000480	refseq:NP_115786.1|ensembl:ENSG00000168172(gene)|ensembl:ENST00000307602(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR008636(HOOK)|interpro:IPR036872|interpro:IPR043936|rcsb pdb:5J8E|rcsb pdb:6B9H|go:"GO:0034454"(microtubule anchoring at centrosome)	-	-	-	figure legend:2 D|delivery method:O60505 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/05/27	2014/10/16	rogid:4IGV7T0fw+Y2rwPdICqixuiOM809606	rogid:hzM38dyr89rY7z71px9K4rVNL6s9606	intact-crc:DB82CD180F86E2BB|rigid:TzwAJeGv35d4GSIx0QYGVYoTGYc	false	v5 tag:c-c	necessary binding region:556-718	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q86VS8	uniprotkb:P21757	intact:EBI-1777078|uniprotkb:Q8NBH0|uniprotkb:Q9BY13|uniprotkb:D3DSY8|ensembl:ENSP00000305699	intact:EBI-1776976|uniprotkb:P21759|uniprotkb:Q45F10|uniprotkb:O60505|uniprotkb:D3DSP3|ensembl:ENSP00000262101	psi-mi:hook3_human(display_long)|uniprotkb:HOOK3(gene name)|psi-mi:HOOK3(display_short)	psi-mi:msre_human(display_long)|uniprotkb:MSR1(gene name)|psi-mi:MSR1(display_short)|uniprotkb:SCARA1(gene name synonym)|uniprotkb:Macrophage acetylated LDL receptor I and II(gene name synonym)|uniprotkb:Scavenger receptor class A member 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sano et al. (2007)	pubmed:17237231|imex:IM-19810	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1777163|imex:IM-19810-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115786.1|ensembl:ENSG00000168172(gene)|ensembl:ENST00000307602(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR008636(HOOK)|interpro:IPR036872|interpro:IPR043936|rcsb pdb:5J8E|rcsb pdb:6B9H|go:"GO:0034454"(microtubule anchoring at centrosome)	refseq:NP_002436.1|refseq:NP_619729.1|refseq:NP_619730.1|ensembl:ENSG00000038945(gene)|ensembl:ENST00000262101(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097242"(amyloid-beta clearance)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR003543(Macrophage scavenger receptor)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|mint:P21757|reactome:R-HSA-3000480	-	-	-	figure legend:3|delivery method:O60505 transfection|agonist:Incubation of cells with fucoidin, an SR-A ligand, increased the levels of this interaction.|comment:Incubation of cells with mannose did not singificantly affect the levels of this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/05/27	2014/10/16	rogid:hzM38dyr89rY7z71px9K4rVNL6s9606	rogid:4IGV7T0fw+Y2rwPdICqixuiOM809606	intact-crc:983E593BE3655F02|rigid:TzwAJeGv35d4GSIx0QYGVYoTGYc	false	-	v5 tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30204	uniprotkb:Q8BUK6	intact:EBI-1777188|uniprotkb:E9QNQ5|uniprotkb:Q923G0|uniprotkb:Q9QZ56|ensembl:ENSMUSP00000026021	intact:EBI-1777179|uniprotkb:Q8BV48|uniprotkb:Q8BW57|uniprotkb:Q8BY41|uniprotkb:Q540A0|ensembl:ENSMUSP00000046788	psi-mi:msre_mouse(display_long)|uniprotkb:Msr1(gene name)|psi-mi:Msr1(display_short)|uniprotkb:Scvr(gene name synonym)|uniprotkb:Macrophage acetylated LDL receptor I and II(gene name synonym)|uniprotkb:Scavenger receptor type A(gene name synonym)	psi-mi:hook3_mouse(display_long)|uniprotkb:Hook3(gene name)|psi-mi:Hook3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sano et al. (2007)	pubmed:17237231|imex:IM-19810	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1777209|imex:IM-19810-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001106797.1|ensembl:ENSMUSG00000025044(gene)|ensembl:ENSMUST00000026021(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0097242"(amyloid-beta clearance)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR003543(Macrophage scavenger receptor)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|rcsb pdb:6J02|reactome:R-MMU-3000480	refseq:NP_997542.1|ensembl:ENSMUSG00000037234(gene)|ensembl:ENSMUST00000037182(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0030897"(HOPS complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR008636(HOOK)|interpro:IPR036872|interpro:IPR043936|mint:Q8BUK6	-	-	-	figure legend:4 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264)	-	2008/05/27	2014/10/16	rogid:OEBopfQ64yHz6MyWLGjruNYhEdg10090	rogid:PUiCL1lU5asAM+rngKPeVDsgomE10090	intact-crc:BF59FE1E7C42FC5B|rigid:dADnx8hzbRfVjRDvyeCAbMuIOAs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)