#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9H1D0	uniprotkb:P18031	intact:EBI-7198335|ensembl:ENSP00000352358|uniprotkb:Q8TDL3|uniprotkb:Q9H1D1|uniprotkb:Q96LC5|uniprotkb:Q9H296|uniprotkb:Q8WXR8|intact:MINT-1472896|uniprotkb:A4D2I8	intact:EBI-968788|ensembl:ENSP00000360683|uniprotkb:Q5TGD8|uniprotkb:Q9BQV9|uniprotkb:Q9NQQ4	psi-mi:trpv6_human(display_long)|uniprotkb:TRPV6(gene name)|psi-mi:TRPV6(display_short)|uniprotkb:ECAC2(gene name synonym)|uniprotkb:Epithelial calcium channel 2(gene name synonym)|uniprotkb:Calcium transport protein 1(gene name synonym)|uniprotkb:CaT-like(gene name synonym)	psi-mi:ptn1_human(display_long)|uniprotkb:PTPN1(gene name)|psi-mi:PTPN1(display_short)|uniprotkb:PTP1B(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1B(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Sternfeld et al. (2007)	pubmed:17197020|mint:MINT-6671374	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7198329|mint:MINT-6765197	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061116.5|ensembl:ENSG00000165125(gene)|ensembl:ENST00000359396(transcript)|go:"GO:0005216"(ion channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035898"(parathyroid hormone secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098703"(calcium ion import across plasma membrane)|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008344(Epithelial calcium channel)|interpro:IPR008345(Epithelial calcium channel 1)|interpro:IPR020683|interpro:IPR024862|interpro:IPR036770|mint:Q9H1D0|rcsb pdb:6BO8|rcsb pdb:6BO9|rcsb pdb:6BOA|rcsb pdb:6D7S|rcsb pdb:6D7T|rcsb pdb:6E2F|rcsb pdb:7K4A|rcsb pdb:7K4B|rcsb pdb:7K4C|rcsb pdb:7K4D|rcsb pdb:7K4E|rcsb pdb:7K4F|reactome:R-HSA-3295583|mint:MINT-6765202(identity)|uniprotkb:Q9H1D0(Q9H1D0)	ensembl:ENSG00000196396(gene)|ensembl:ENST00000371621(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0097443"(sorting endosome)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:1902202"(regulation of hepatocyte growth factor receptor signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012265(Protein-tyrosine phosphatase, non-receptor type-1, -2)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P18031|rcsb pdb:1A5Y|rcsb pdb:1BZC|rcsb pdb:1BZH|rcsb pdb:1BZJ|rcsb pdb:1C83|rcsb pdb:1C84|rcsb pdb:1C85|rcsb pdb:1C86|rcsb pdb:1C87|rcsb pdb:1C88|rcsb pdb:1ECV|rcsb pdb:1EEN|rcsb pdb:1EEO|rcsb pdb:1G1F|rcsb pdb:1AAX|rcsb pdb:1G1G|rcsb pdb:1G1H|rcsb pdb:1G7F|rcsb pdb:1G7G|rcsb pdb:1GFY|rcsb pdb:1I57|rcsb pdb:1JF7|rcsb pdb:5QFV|rcsb pdb:5QFW|rcsb pdb:5QFX|rcsb pdb:5QFY|rcsb pdb:5QFZ|rcsb pdb:5QG0|rcsb pdb:5QG1|rcsb pdb:5QG2|rcsb pdb:5QG3|rcsb pdb:5QG4|rcsb pdb:5QG5|rcsb pdb:5QG6|rcsb pdb:5QG7|rcsb pdb:5QG8|rcsb pdb:5QG9|rcsb pdb:5QGA|rcsb pdb:5QGB|rcsb pdb:5QGC|rcsb pdb:5QGD|rcsb pdb:5QGE|rcsb pdb:5QGF|rcsb pdb:5T19|rcsb pdb:6B8E|rcsb pdb:6B8T|rcsb pdb:6B8X|rcsb pdb:6B8Z|rcsb pdb:6B90|rcsb pdb:6B95|rcsb pdb:6BAI|rcsb pdb:6CWU|rcsb pdb:6CWV|rcsb pdb:6NTP|rcsb pdb:6OL4|rcsb pdb:6OLQ|rcsb pdb:6OLV|rcsb pdb:1KAK|rcsb pdb:1KAV|rcsb pdb:1L8G|rcsb pdb:1LQF|rcsb pdb:1NL9|rcsb pdb:1NNY|rcsb pdb:1NO6|rcsb pdb:1NWE|rcsb pdb:1NWL|rcsb pdb:1NZ7|rcsb pdb:1OEM|rcsb pdb:1OEO|rcsb pdb:1OES|rcsb pdb:1OET|rcsb pdb:1OEU|rcsb pdb:1OEV|rcsb pdb:1ONY|rcsb pdb:1ONZ|rcsb pdb:1PA1|rcsb pdb:1PH0|rcsb pdb:1PTT|rcsb pdb:1PTU|rcsb pdb:1PTV|rcsb pdb:1PTY|rcsb pdb:1PXH|rcsb pdb:1PYN|rcsb pdb:1Q1M|rcsb pdb:1Q6J|rcsb pdb:1Q6M|rcsb pdb:1Q6N|rcsb pdb:1Q6P|rcsb pdb:1Q6S|rcsb pdb:1Q6T|rcsb pdb:1QXK|rcsb pdb:1SUG|rcsb pdb:1T48|rcsb pdb:1T49|rcsb pdb:1T4J|rcsb pdb:1WAX|rcsb pdb:1XBO|rcsb pdb:2AZR|rcsb pdb:2B07|rcsb pdb:2B4S|rcsb pdb:2BGD|rcsb pdb:2NT7|rcsb pdb:2BGE|rcsb pdb:2CM2|rcsb pdb:2NTA|rcsb pdb:2CM3|rcsb pdb:2CM7|rcsb pdb:2QBP|rcsb pdb:2CM8|rcsb pdb:2CMA|rcsb pdb:2QBQ|rcsb pdb:2QBR|rcsb pdb:2CMB|rcsb pdb:2CMC|rcsb pdb:2CNE|rcsb pdb:2QBS|rcsb pdb:2CNF|rcsb pdb:2CNG|rcsb pdb:2CNH|rcsb pdb:2CNI|rcsb pdb:2F6F|rcsb pdb:2F6T|rcsb pdb:2VEU|rcsb pdb:2F6V|rcsb pdb:2F6W|rcsb pdb:2F6Y|rcsb pdb:2VEV|rcsb pdb:2VEW|rcsb pdb:2VEX|rcsb pdb:2VEY|rcsb pdb:2F6Z|rcsb pdb:2ZMM|rcsb pdb:2F70|rcsb pdb:2F71|rcsb pdb:2ZN7|rcsb pdb:3A5J|rcsb pdb:2FJM|rcsb pdb:2FJN|rcsb pdb:2H4G|rcsb pdb:2H4K|rcsb pdb:2HB1|rcsb pdb:2HNP|rcsb pdb:2HNQ|rcsb pdb:3A5K|rcsb pdb:3CWE|rcsb pdb:6OMY|rcsb pdb:3D9C|rcsb pdb:3EAX|rcsb pdb:4QAP|rcsb pdb:4QBE|rcsb pdb:3EB1|rcsb pdb:4QBW|rcsb pdb:4Y14|rcsb pdb:4ZRT|rcsb pdb:5K9V|rcsb pdb:5K9W|rcsb pdb:5KA0|rcsb pdb:5KA1|rcsb pdb:5KA2|rcsb pdb:5KA3|rcsb pdb:5KA4|rcsb pdb:5KA7|rcsb pdb:5KA8|rcsb pdb:5KA9|rcsb pdb:5KAA|rcsb pdb:5KAB|rcsb pdb:5KAC|rcsb pdb:5KAD|rcsb pdb:5QDE|rcsb pdb:5QDF|rcsb pdb:5QDG|rcsb pdb:5QDH|rcsb pdb:5QDI|rcsb pdb:5QDJ|rcsb pdb:5QDK|rcsb pdb:5QDL|rcsb pdb:5QDM|rcsb pdb:5QDN|rcsb pdb:3EU0|rcsb pdb:3I7Z|rcsb pdb:3I80|rcsb pdb:3QKP|rcsb pdb:3QKQ|rcsb pdb:3SME|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:3ZV2|rcsb pdb:4BJO|rcsb pdb:4I8N|rcsb pdb:4QAH|rcsb pdb:5QDO|rcsb pdb:5QDP|rcsb pdb:5QDQ|rcsb pdb:5QDR|rcsb pdb:5QDS|rcsb pdb:6PG0|rcsb pdb:6PGT|rcsb pdb:6PHA|rcsb pdb:6PHS|rcsb pdb:6PM8|rcsb pdb:6W30|rcsb pdb:7KEN|rcsb pdb:7L0C|rcsb pdb:7L0H|rcsb pdb:7LFO|rcsb pdb:7MM1|reactome:R-HSA-354192|reactome:R-HSA-6807004|reactome:R-HSA-877312|reactome:R-HSA-8849472|reactome:R-HSA-9022699|reactome:R-HSA-912694|reactome:R-HSA-982772|rcsb pdb:6PFW|rcsb pdb:5QDW|rcsb pdb:5QDX|rcsb pdb:5QDY|rcsb pdb:5QDZ|rcsb pdb:5QE0|rcsb pdb:5QE1|rcsb pdb:5QDT|rcsb pdb:5QDU|rcsb pdb:5QE2|rcsb pdb:5QE3|rcsb pdb:5QE4|rcsb pdb:5QE5|rcsb pdb:5QE6|rcsb pdb:5QE7|rcsb pdb:5QE8|rcsb pdb:5QE9|rcsb pdb:5QEA|rcsb pdb:5QEB|rcsb pdb:5QEC|rcsb pdb:5QED|rcsb pdb:5QEE|rcsb pdb:5QEF|rcsb pdb:5QEG|rcsb pdb:5QEH|rcsb pdb:5QEI|rcsb pdb:5QEJ|rcsb pdb:5QDV|rcsb pdb:5QEK|rcsb pdb:5QEL|rcsb pdb:5QEM|rcsb pdb:5QEN|rcsb pdb:5QEO|rcsb pdb:5QEP|rcsb pdb:5QEQ|rcsb pdb:5QER|rcsb pdb:5QES|rcsb pdb:5QET|rcsb pdb:5QEU|rcsb pdb:5QEV|rcsb pdb:5QEW|rcsb pdb:5QEX|rcsb pdb:5QEY|rcsb pdb:5QEZ|rcsb pdb:5QF0|rcsb pdb:5QF1|rcsb pdb:5QF2|rcsb pdb:5QF3|rcsb pdb:5QF4|rcsb pdb:5QF5|rcsb pdb:5QF6|rcsb pdb:5QF7|rcsb pdb:5QF8|rcsb pdb:5QF9|rcsb pdb:5QFA|rcsb pdb:5QFB|rcsb pdb:5QFC|rcsb pdb:5QFD|rcsb pdb:5QFE|rcsb pdb:5QFF|rcsb pdb:5QFG|rcsb pdb:5QFH|rcsb pdb:5QFI|rcsb pdb:5QFJ|rcsb pdb:5QFK|rcsb pdb:5QFL|rcsb pdb:5QFM|rcsb pdb:5QFN|rcsb pdb:5QFO|rcsb pdb:5QFP|rcsb pdb:5QFQ|rcsb pdb:5QFR|rcsb pdb:5QFS|rcsb pdb:5QFT|rcsb pdb:5QFU|refseq:NP_001265547.1|refseq:NP_002818.1|dip:DIP-38014N|mint:MINT-6765198(identity)|uniprotkb:P18031(P18031)	-	function:"Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating"|comment:mint|comment:homomint	-	figure legend:F1B|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/18	2015/06/10	rogid:GHCFRZj4WP3CoS6iZwWasF2FS3U9606	rogid:yz+WjBWu7IXrpAfeMUJ2s0e0ACM9606	intact-crc:F2B28E447D81C9B9|rigid:Gt+uWgTHLfnnq7ydeTsWQd4Snxw	false	yellow fluorescent protein tag:?-?(MINT-6765204)	glutathione s tranferase tag:?-?(MINT-6765200)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9H1D0	uniprotkb:P18031	intact:EBI-7198335|ensembl:ENSP00000352358|uniprotkb:Q8TDL3|uniprotkb:Q9H1D1|uniprotkb:Q96LC5|uniprotkb:Q9H296|uniprotkb:Q8WXR8|intact:MINT-1472896|uniprotkb:A4D2I8	intact:EBI-968788|ensembl:ENSP00000360683|uniprotkb:Q5TGD8|uniprotkb:Q9BQV9|uniprotkb:Q9NQQ4	psi-mi:trpv6_human(display_long)|uniprotkb:TRPV6(gene name)|psi-mi:TRPV6(display_short)|uniprotkb:ECAC2(gene name synonym)|uniprotkb:Epithelial calcium channel 2(gene name synonym)|uniprotkb:Calcium transport protein 1(gene name synonym)|uniprotkb:CaT-like(gene name synonym)	psi-mi:ptn1_human(display_long)|uniprotkb:PTPN1(gene name)|psi-mi:PTPN1(display_short)|uniprotkb:PTP1B(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sternfeld et al. (2007)	pubmed:17197020|mint:MINT-6671374	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7198647|mint:MINT-6765208	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061116.5|ensembl:ENSG00000165125(gene)|ensembl:ENST00000359396(transcript)|go:"GO:0005216"(ion channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035898"(parathyroid hormone secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098703"(calcium ion import across plasma membrane)|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008344(Epithelial calcium channel)|interpro:IPR008345(Epithelial calcium channel 1)|interpro:IPR020683|interpro:IPR024862|interpro:IPR036770|mint:Q9H1D0|rcsb pdb:6BO8|rcsb pdb:6BO9|rcsb pdb:6BOA|rcsb pdb:6D7S|rcsb pdb:6D7T|rcsb pdb:6E2F|rcsb pdb:7K4A|rcsb pdb:7K4B|rcsb pdb:7K4C|rcsb pdb:7K4D|rcsb pdb:7K4E|rcsb pdb:7K4F|reactome:R-HSA-3295583|mint:MINT-6765213(identity)|uniprotkb:Q9H1D0(Q9H1D0)	ensembl:ENSG00000196396(gene)|ensembl:ENST00000371621(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0097443"(sorting endosome)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:1902202"(regulation of hepatocyte growth factor receptor signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012265(Protein-tyrosine phosphatase, non-receptor type-1, -2)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P18031|rcsb pdb:1A5Y|rcsb pdb:1BZC|rcsb pdb:1BZH|rcsb pdb:1BZJ|rcsb pdb:1C83|rcsb pdb:1C84|rcsb pdb:1C85|rcsb pdb:1C86|rcsb pdb:1C87|rcsb pdb:1C88|rcsb pdb:1ECV|rcsb pdb:1EEN|rcsb pdb:1EEO|rcsb pdb:1G1F|rcsb pdb:1AAX|rcsb pdb:1G1G|rcsb pdb:1G1H|rcsb pdb:1G7F|rcsb pdb:1G7G|rcsb pdb:1GFY|rcsb pdb:1I57|rcsb pdb:1JF7|rcsb pdb:5QFV|rcsb pdb:5QFW|rcsb pdb:5QFX|rcsb pdb:5QFY|rcsb pdb:5QFZ|rcsb pdb:5QG0|rcsb pdb:5QG1|rcsb pdb:5QG2|rcsb pdb:5QG3|rcsb pdb:5QG4|rcsb pdb:5QG5|rcsb pdb:5QG6|rcsb pdb:5QG7|rcsb pdb:5QG8|rcsb pdb:5QG9|rcsb pdb:5QGA|rcsb pdb:5QGB|rcsb pdb:5QGC|rcsb pdb:5QGD|rcsb pdb:5QGE|rcsb pdb:5QGF|rcsb pdb:5T19|rcsb pdb:6B8E|rcsb pdb:6B8T|rcsb pdb:6B8X|rcsb pdb:6B8Z|rcsb pdb:6B90|rcsb pdb:6B95|rcsb pdb:6BAI|rcsb pdb:6CWU|rcsb pdb:6CWV|rcsb pdb:6NTP|rcsb pdb:6OL4|rcsb pdb:6OLQ|rcsb pdb:6OLV|rcsb pdb:1KAK|rcsb pdb:1KAV|rcsb pdb:1L8G|rcsb pdb:1LQF|rcsb pdb:1NL9|rcsb pdb:1NNY|rcsb pdb:1NO6|rcsb pdb:1NWE|rcsb pdb:1NWL|rcsb pdb:1NZ7|rcsb pdb:1OEM|rcsb pdb:1OEO|rcsb pdb:1OES|rcsb pdb:1OET|rcsb pdb:1OEU|rcsb pdb:1OEV|rcsb pdb:1ONY|rcsb pdb:1ONZ|rcsb pdb:1PA1|rcsb pdb:1PH0|rcsb pdb:1PTT|rcsb pdb:1PTU|rcsb pdb:1PTV|rcsb pdb:1PTY|rcsb pdb:1PXH|rcsb pdb:1PYN|rcsb pdb:1Q1M|rcsb pdb:1Q6J|rcsb pdb:1Q6M|rcsb pdb:1Q6N|rcsb pdb:1Q6P|rcsb pdb:1Q6S|rcsb pdb:1Q6T|rcsb pdb:1QXK|rcsb pdb:1SUG|rcsb pdb:1T48|rcsb pdb:1T49|rcsb pdb:1T4J|rcsb pdb:1WAX|rcsb pdb:1XBO|rcsb pdb:2AZR|rcsb pdb:2B07|rcsb pdb:2B4S|rcsb pdb:2BGD|rcsb pdb:2NT7|rcsb pdb:2BGE|rcsb pdb:2CM2|rcsb pdb:2NTA|rcsb pdb:2CM3|rcsb pdb:2CM7|rcsb pdb:2QBP|rcsb pdb:2CM8|rcsb pdb:2CMA|rcsb pdb:2QBQ|rcsb pdb:2QBR|rcsb pdb:2CMB|rcsb pdb:2CMC|rcsb pdb:2CNE|rcsb pdb:2QBS|rcsb pdb:2CNF|rcsb pdb:2CNG|rcsb pdb:2CNH|rcsb pdb:2CNI|rcsb pdb:2F6F|rcsb pdb:2F6T|rcsb pdb:2VEU|rcsb pdb:2F6V|rcsb pdb:2F6W|rcsb pdb:2F6Y|rcsb pdb:2VEV|rcsb pdb:2VEW|rcsb pdb:2VEX|rcsb pdb:2VEY|rcsb pdb:2F6Z|rcsb pdb:2ZMM|rcsb pdb:2F70|rcsb pdb:2F71|rcsb pdb:2ZN7|rcsb pdb:3A5J|rcsb pdb:2FJM|rcsb pdb:2FJN|rcsb pdb:2H4G|rcsb pdb:2H4K|rcsb pdb:2HB1|rcsb pdb:2HNP|rcsb pdb:2HNQ|rcsb pdb:3A5K|rcsb pdb:3CWE|rcsb pdb:6OMY|rcsb pdb:3D9C|rcsb pdb:3EAX|rcsb pdb:4QAP|rcsb pdb:4QBE|rcsb pdb:3EB1|rcsb pdb:4QBW|rcsb pdb:4Y14|rcsb pdb:4ZRT|rcsb pdb:5K9V|rcsb pdb:5K9W|rcsb pdb:5KA0|rcsb pdb:5KA1|rcsb pdb:5KA2|rcsb pdb:5KA3|rcsb pdb:5KA4|rcsb pdb:5KA7|rcsb pdb:5KA8|rcsb pdb:5KA9|rcsb pdb:5KAA|rcsb pdb:5KAB|rcsb pdb:5KAC|rcsb pdb:5KAD|rcsb pdb:5QDE|rcsb pdb:5QDF|rcsb pdb:5QDG|rcsb pdb:5QDH|rcsb pdb:5QDI|rcsb pdb:5QDJ|rcsb pdb:5QDK|rcsb pdb:5QDL|rcsb pdb:5QDM|rcsb pdb:5QDN|rcsb pdb:3EU0|rcsb pdb:3I7Z|rcsb pdb:3I80|rcsb pdb:3QKP|rcsb pdb:3QKQ|rcsb pdb:3SME|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:3ZV2|rcsb pdb:4BJO|rcsb pdb:4I8N|rcsb pdb:4QAH|rcsb pdb:5QDO|rcsb pdb:5QDP|rcsb pdb:5QDQ|rcsb pdb:5QDR|rcsb pdb:5QDS|rcsb pdb:6PG0|rcsb pdb:6PGT|rcsb pdb:6PHA|rcsb pdb:6PHS|rcsb pdb:6PM8|rcsb pdb:6W30|rcsb pdb:7KEN|rcsb pdb:7L0C|rcsb pdb:7L0H|rcsb pdb:7LFO|rcsb pdb:7MM1|reactome:R-HSA-354192|reactome:R-HSA-6807004|reactome:R-HSA-877312|reactome:R-HSA-8849472|reactome:R-HSA-9022699|reactome:R-HSA-912694|reactome:R-HSA-982772|rcsb pdb:6PFW|rcsb pdb:5QDW|rcsb pdb:5QDX|rcsb pdb:5QDY|rcsb pdb:5QDZ|rcsb pdb:5QE0|rcsb pdb:5QE1|rcsb pdb:5QDT|rcsb pdb:5QDU|rcsb pdb:5QE2|rcsb pdb:5QE3|rcsb pdb:5QE4|rcsb pdb:5QE5|rcsb pdb:5QE6|rcsb pdb:5QE7|rcsb pdb:5QE8|rcsb pdb:5QE9|rcsb pdb:5QEA|rcsb pdb:5QEB|rcsb pdb:5QEC|rcsb pdb:5QED|rcsb pdb:5QEE|rcsb pdb:5QEF|rcsb pdb:5QEG|rcsb pdb:5QEH|rcsb pdb:5QEI|rcsb pdb:5QEJ|rcsb pdb:5QDV|rcsb pdb:5QEK|rcsb pdb:5QEL|rcsb pdb:5QEM|rcsb pdb:5QEN|rcsb pdb:5QEO|rcsb pdb:5QEP|rcsb pdb:5QEQ|rcsb pdb:5QER|rcsb pdb:5QES|rcsb pdb:5QET|rcsb pdb:5QEU|rcsb pdb:5QEV|rcsb pdb:5QEW|rcsb pdb:5QEX|rcsb pdb:5QEY|rcsb pdb:5QEZ|rcsb pdb:5QF0|rcsb pdb:5QF1|rcsb pdb:5QF2|rcsb pdb:5QF3|rcsb pdb:5QF4|rcsb pdb:5QF5|rcsb pdb:5QF6|rcsb pdb:5QF7|rcsb pdb:5QF8|rcsb pdb:5QF9|rcsb pdb:5QFA|rcsb pdb:5QFB|rcsb pdb:5QFC|rcsb pdb:5QFD|rcsb pdb:5QFE|rcsb pdb:5QFF|rcsb pdb:5QFG|rcsb pdb:5QFH|rcsb pdb:5QFI|rcsb pdb:5QFJ|rcsb pdb:5QFK|rcsb pdb:5QFL|rcsb pdb:5QFM|rcsb pdb:5QFN|rcsb pdb:5QFO|rcsb pdb:5QFP|rcsb pdb:5QFQ|rcsb pdb:5QFR|rcsb pdb:5QFS|rcsb pdb:5QFT|rcsb pdb:5QFU|refseq:NP_001265547.1|refseq:NP_002818.1|dip:DIP-38014N|mint:MINT-6765209(identity)|uniprotkb:P18031(P18031)	-	function:"Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating"|comment:mint|comment:homomint	-	figure legend:F3A|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/09/18	2015/06/10	rogid:GHCFRZj4WP3CoS6iZwWasF2FS3U9606	rogid:yz+WjBWu7IXrpAfeMUJ2s0e0ACM9606	intact-crc:585A41C085BD0458|rigid:Gt+uWgTHLfnnq7ydeTsWQd4Snxw	false	binding-associated region:41-111(MINT-6765215)|yellow fluorescent protein tag:?-?(MINT-6765217)	glutathione s tranferase tag:?-?(MINT-6765211)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9R186	uniprotkb:P18031	intact:EBI-7198720|intact:UNK-5555281	intact:EBI-968788|ensembl:ENSP00000360683|uniprotkb:Q5TGD8|uniprotkb:Q9BQV9|uniprotkb:Q9NQQ4	psi-mi:trpv6_rat(display_long)|uniprotkb:Trpv6(gene name)|psi-mi:Trpv6(display_short)|uniprotkb:Epithelial calcium channel 2(gene name synonym)|uniprotkb:Calcium transport protein 1(gene name synonym)	psi-mi:ptn1_human(display_long)|uniprotkb:PTPN1(gene name)|psi-mi:PTPN1(display_short)|uniprotkb:PTP1B(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sternfeld et al. (2007)	pubmed:17197020|mint:MINT-6671374	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7198714|mint:MINT-6765224	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9R186|go:"GO:0005216"(ion channel activity)|go:"GO:0005227"(calcium activated cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035898"(parathyroid hormone secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098703"(calcium ion import across plasma membrane)|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008344(Epithelial calcium channel)|interpro:IPR008345(Epithelial calcium channel 1)|interpro:IPR020683|interpro:IPR024862|interpro:IPR036770|rcsb pdb:5IWK|rcsb pdb:5IWP|rcsb pdb:5IWR|rcsb pdb:5IWT|rcsb pdb:5WO6|rcsb pdb:5WO7|rcsb pdb:5WO8|rcsb pdb:5WO9|rcsb pdb:5WOA|rcsb pdb:6BOB|rcsb pdb:6D7O|rcsb pdb:6D7P|rcsb pdb:6D7Q|rcsb pdb:6D7V|rcsb pdb:6D7X|rcsb pdb:6E2G|reactome:R-RNO-3295583|rgd:69335|refseq:NP_446138.1|dip:DIP-47769N|mint:MINT-6765228(identity)|uniprotkb:Q9R186(Q9R186)	ensembl:ENSG00000196396(gene)|ensembl:ENST00000371621(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0097443"(sorting endosome)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:1902202"(regulation of hepatocyte growth factor receptor signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012265(Protein-tyrosine phosphatase, non-receptor type-1, -2)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P18031|rcsb pdb:1A5Y|rcsb pdb:1BZC|rcsb pdb:1BZH|rcsb pdb:1BZJ|rcsb pdb:1C83|rcsb pdb:1C84|rcsb pdb:1C85|rcsb pdb:1C86|rcsb pdb:1C87|rcsb pdb:1C88|rcsb pdb:1ECV|rcsb pdb:1EEN|rcsb pdb:1EEO|rcsb pdb:1G1F|rcsb pdb:1AAX|rcsb pdb:1G1G|rcsb pdb:1G1H|rcsb pdb:1G7F|rcsb pdb:1G7G|rcsb pdb:1GFY|rcsb pdb:1I57|rcsb pdb:1JF7|rcsb pdb:5QFV|rcsb pdb:5QFW|rcsb pdb:5QFX|rcsb pdb:5QFY|rcsb pdb:5QFZ|rcsb pdb:5QG0|rcsb pdb:5QG1|rcsb pdb:5QG2|rcsb pdb:5QG3|rcsb pdb:5QG4|rcsb pdb:5QG5|rcsb pdb:5QG6|rcsb pdb:5QG7|rcsb pdb:5QG8|rcsb pdb:5QG9|rcsb pdb:5QGA|rcsb pdb:5QGB|rcsb pdb:5QGC|rcsb pdb:5QGD|rcsb pdb:5QGE|rcsb pdb:5QGF|rcsb pdb:5T19|rcsb pdb:6B8E|rcsb pdb:6B8T|rcsb pdb:6B8X|rcsb pdb:6B8Z|rcsb pdb:6B90|rcsb pdb:6B95|rcsb pdb:6BAI|rcsb pdb:6CWU|rcsb pdb:6CWV|rcsb pdb:6NTP|rcsb pdb:6OL4|rcsb pdb:6OLQ|rcsb pdb:6OLV|rcsb pdb:1KAK|rcsb pdb:1KAV|rcsb pdb:1L8G|rcsb pdb:1LQF|rcsb pdb:1NL9|rcsb pdb:1NNY|rcsb pdb:1NO6|rcsb pdb:1NWE|rcsb pdb:1NWL|rcsb pdb:1NZ7|rcsb pdb:1OEM|rcsb pdb:1OEO|rcsb pdb:1OES|rcsb pdb:1OET|rcsb pdb:1OEU|rcsb pdb:1OEV|rcsb pdb:1ONY|rcsb pdb:1ONZ|rcsb pdb:1PA1|rcsb pdb:1PH0|rcsb pdb:1PTT|rcsb pdb:1PTU|rcsb pdb:1PTV|rcsb pdb:1PTY|rcsb pdb:1PXH|rcsb pdb:1PYN|rcsb pdb:1Q1M|rcsb pdb:1Q6J|rcsb pdb:1Q6M|rcsb pdb:1Q6N|rcsb pdb:1Q6P|rcsb pdb:1Q6S|rcsb pdb:1Q6T|rcsb pdb:1QXK|rcsb pdb:1SUG|rcsb pdb:1T48|rcsb pdb:1T49|rcsb pdb:1T4J|rcsb pdb:1WAX|rcsb pdb:1XBO|rcsb pdb:2AZR|rcsb pdb:2B07|rcsb pdb:2B4S|rcsb pdb:2BGD|rcsb pdb:2NT7|rcsb pdb:2BGE|rcsb pdb:2CM2|rcsb pdb:2NTA|rcsb pdb:2CM3|rcsb pdb:2CM7|rcsb pdb:2QBP|rcsb pdb:2CM8|rcsb pdb:2CMA|rcsb pdb:2QBQ|rcsb pdb:2QBR|rcsb pdb:2CMB|rcsb pdb:2CMC|rcsb pdb:2CNE|rcsb pdb:2QBS|rcsb pdb:2CNF|rcsb pdb:2CNG|rcsb pdb:2CNH|rcsb pdb:2CNI|rcsb pdb:2F6F|rcsb pdb:2F6T|rcsb pdb:2VEU|rcsb pdb:2F6V|rcsb pdb:2F6W|rcsb pdb:2F6Y|rcsb pdb:2VEV|rcsb pdb:2VEW|rcsb pdb:2VEX|rcsb pdb:2VEY|rcsb pdb:2F6Z|rcsb pdb:2ZMM|rcsb pdb:2F70|rcsb pdb:2F71|rcsb pdb:2ZN7|rcsb pdb:3A5J|rcsb pdb:2FJM|rcsb pdb:2FJN|rcsb pdb:2H4G|rcsb pdb:2H4K|rcsb pdb:2HB1|rcsb pdb:2HNP|rcsb pdb:2HNQ|rcsb pdb:3A5K|rcsb pdb:3CWE|rcsb pdb:6OMY|rcsb pdb:3D9C|rcsb pdb:3EAX|rcsb pdb:4QAP|rcsb pdb:4QBE|rcsb pdb:3EB1|rcsb pdb:4QBW|rcsb pdb:4Y14|rcsb pdb:4ZRT|rcsb pdb:5K9V|rcsb pdb:5K9W|rcsb pdb:5KA0|rcsb pdb:5KA1|rcsb pdb:5KA2|rcsb pdb:5KA3|rcsb pdb:5KA4|rcsb pdb:5KA7|rcsb pdb:5KA8|rcsb pdb:5KA9|rcsb pdb:5KAA|rcsb pdb:5KAB|rcsb pdb:5KAC|rcsb pdb:5KAD|rcsb pdb:5QDE|rcsb pdb:5QDF|rcsb pdb:5QDG|rcsb pdb:5QDH|rcsb pdb:5QDI|rcsb pdb:5QDJ|rcsb pdb:5QDK|rcsb pdb:5QDL|rcsb pdb:5QDM|rcsb pdb:5QDN|rcsb pdb:3EU0|rcsb pdb:3I7Z|rcsb pdb:3I80|rcsb pdb:3QKP|rcsb pdb:3QKQ|rcsb pdb:3SME|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:3ZV2|rcsb pdb:4BJO|rcsb pdb:4I8N|rcsb pdb:4QAH|rcsb pdb:5QDO|rcsb pdb:5QDP|rcsb pdb:5QDQ|rcsb pdb:5QDR|rcsb pdb:5QDS|rcsb pdb:6PG0|rcsb pdb:6PGT|rcsb pdb:6PHA|rcsb pdb:6PHS|rcsb pdb:6PM8|rcsb pdb:6W30|rcsb pdb:7KEN|rcsb pdb:7L0C|rcsb pdb:7L0H|rcsb pdb:7LFO|rcsb pdb:7MM1|reactome:R-HSA-354192|reactome:R-HSA-6807004|reactome:R-HSA-877312|reactome:R-HSA-8849472|reactome:R-HSA-9022699|reactome:R-HSA-912694|reactome:R-HSA-982772|rcsb pdb:6PFW|rcsb pdb:5QDW|rcsb pdb:5QDX|rcsb pdb:5QDY|rcsb pdb:5QDZ|rcsb pdb:5QE0|rcsb pdb:5QE1|rcsb pdb:5QDT|rcsb pdb:5QDU|rcsb pdb:5QE2|rcsb pdb:5QE3|rcsb pdb:5QE4|rcsb pdb:5QE5|rcsb pdb:5QE6|rcsb pdb:5QE7|rcsb pdb:5QE8|rcsb pdb:5QE9|rcsb pdb:5QEA|rcsb pdb:5QEB|rcsb pdb:5QEC|rcsb pdb:5QED|rcsb pdb:5QEE|rcsb pdb:5QEF|rcsb pdb:5QEG|rcsb pdb:5QEH|rcsb pdb:5QEI|rcsb pdb:5QEJ|rcsb pdb:5QDV|rcsb pdb:5QEK|rcsb pdb:5QEL|rcsb pdb:5QEM|rcsb pdb:5QEN|rcsb pdb:5QEO|rcsb pdb:5QEP|rcsb pdb:5QEQ|rcsb pdb:5QER|rcsb pdb:5QES|rcsb pdb:5QET|rcsb pdb:5QEU|rcsb pdb:5QEV|rcsb pdb:5QEW|rcsb pdb:5QEX|rcsb pdb:5QEY|rcsb pdb:5QEZ|rcsb pdb:5QF0|rcsb pdb:5QF1|rcsb pdb:5QF2|rcsb pdb:5QF3|rcsb pdb:5QF4|rcsb pdb:5QF5|rcsb pdb:5QF6|rcsb pdb:5QF7|rcsb pdb:5QF8|rcsb pdb:5QF9|rcsb pdb:5QFA|rcsb pdb:5QFB|rcsb pdb:5QFC|rcsb pdb:5QFD|rcsb pdb:5QFE|rcsb pdb:5QFF|rcsb pdb:5QFG|rcsb pdb:5QFH|rcsb pdb:5QFI|rcsb pdb:5QFJ|rcsb pdb:5QFK|rcsb pdb:5QFL|rcsb pdb:5QFM|rcsb pdb:5QFN|rcsb pdb:5QFO|rcsb pdb:5QFP|rcsb pdb:5QFQ|rcsb pdb:5QFR|rcsb pdb:5QFS|rcsb pdb:5QFT|rcsb pdb:5QFU|refseq:NP_001265547.1|refseq:NP_002818.1|dip:DIP-38014N|mint:MINT-6765225(identity)|uniprotkb:P18031(P18031)	-	comment:mint|function:"Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating"	-	figure legend:F3B|comment:Interaction occurs in cell expressing SRC kinase|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2008/09/18	2015/06/10	rogid:juqO6UkILpdNAuG+bhvVekrIFis10116	rogid:yz+WjBWu7IXrpAfeMUJ2s0e0ACM9606	intact-crc:55D1889B4E844675|rigid:2O4RqHwLbxmL9O0qbXPF/OA/poI	false	binding-associated region:41-366(MINT-6785507)|tag:?-?(MINT-6785505)	tag:?-?(MINT-6785502)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H1D0	uniprotkb:P18031	intact:EBI-7198335|ensembl:ENSP00000352358|uniprotkb:Q8TDL3|uniprotkb:Q9H1D1|uniprotkb:Q96LC5|uniprotkb:Q9H296|uniprotkb:Q8WXR8|intact:MINT-1472896|uniprotkb:A4D2I8	intact:EBI-968788|ensembl:ENSP00000360683|uniprotkb:Q5TGD8|uniprotkb:Q9BQV9|uniprotkb:Q9NQQ4	psi-mi:trpv6_human(display_long)|uniprotkb:TRPV6(gene name)|psi-mi:TRPV6(display_short)|uniprotkb:ECAC2(gene name synonym)|uniprotkb:Epithelial calcium channel 2(gene name synonym)|uniprotkb:Calcium transport protein 1(gene name synonym)|uniprotkb:CaT-like(gene name synonym)	psi-mi:ptn1_human(display_long)|uniprotkb:PTPN1(gene name)|psi-mi:PTPN1(display_short)|uniprotkb:PTP1B(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1B(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Sternfeld et al. (2007)	pubmed:17197020|mint:MINT-6671374	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7198883|mint:MINT-6765232	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061116.5|ensembl:ENSG00000165125(gene)|ensembl:ENST00000359396(transcript)|go:"GO:0005216"(ion channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035898"(parathyroid hormone secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098703"(calcium ion import across plasma membrane)|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008344(Epithelial calcium channel)|interpro:IPR008345(Epithelial calcium channel 1)|interpro:IPR020683|interpro:IPR024862|interpro:IPR036770|mint:Q9H1D0|rcsb pdb:6BO8|rcsb pdb:6BO9|rcsb pdb:6BOA|rcsb pdb:6D7S|rcsb pdb:6D7T|rcsb pdb:6E2F|rcsb pdb:7K4A|rcsb pdb:7K4B|rcsb pdb:7K4C|rcsb pdb:7K4D|rcsb pdb:7K4E|rcsb pdb:7K4F|reactome:R-HSA-3295583|mint:MINT-6765233(identity)|uniprotkb:Q9H1D0(Q9H1D0)	ensembl:ENSG00000196396(gene)|ensembl:ENST00000371621(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0097443"(sorting endosome)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:1902202"(regulation of hepatocyte growth factor receptor signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012265(Protein-tyrosine phosphatase, non-receptor type-1, -2)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P18031|rcsb pdb:1A5Y|rcsb pdb:1BZC|rcsb pdb:1BZH|rcsb pdb:1BZJ|rcsb pdb:1C83|rcsb pdb:1C84|rcsb pdb:1C85|rcsb pdb:1C86|rcsb pdb:1C87|rcsb pdb:1C88|rcsb pdb:1ECV|rcsb pdb:1EEN|rcsb pdb:1EEO|rcsb pdb:1G1F|rcsb pdb:1AAX|rcsb pdb:1G1G|rcsb pdb:1G1H|rcsb pdb:1G7F|rcsb pdb:1G7G|rcsb pdb:1GFY|rcsb pdb:1I57|rcsb pdb:1JF7|rcsb pdb:5QFV|rcsb pdb:5QFW|rcsb pdb:5QFX|rcsb pdb:5QFY|rcsb pdb:5QFZ|rcsb pdb:5QG0|rcsb pdb:5QG1|rcsb pdb:5QG2|rcsb pdb:5QG3|rcsb pdb:5QG4|rcsb pdb:5QG5|rcsb pdb:5QG6|rcsb pdb:5QG7|rcsb pdb:5QG8|rcsb pdb:5QG9|rcsb pdb:5QGA|rcsb pdb:5QGB|rcsb pdb:5QGC|rcsb pdb:5QGD|rcsb pdb:5QGE|rcsb pdb:5QGF|rcsb pdb:5T19|rcsb pdb:6B8E|rcsb pdb:6B8T|rcsb pdb:6B8X|rcsb pdb:6B8Z|rcsb pdb:6B90|rcsb pdb:6B95|rcsb pdb:6BAI|rcsb pdb:6CWU|rcsb pdb:6CWV|rcsb pdb:6NTP|rcsb pdb:6OL4|rcsb pdb:6OLQ|rcsb pdb:6OLV|rcsb pdb:1KAK|rcsb pdb:1KAV|rcsb pdb:1L8G|rcsb pdb:1LQF|rcsb pdb:1NL9|rcsb pdb:1NNY|rcsb pdb:1NO6|rcsb pdb:1NWE|rcsb pdb:1NWL|rcsb pdb:1NZ7|rcsb pdb:1OEM|rcsb pdb:1OEO|rcsb pdb:1OES|rcsb pdb:1OET|rcsb pdb:1OEU|rcsb pdb:1OEV|rcsb pdb:1ONY|rcsb pdb:1ONZ|rcsb pdb:1PA1|rcsb pdb:1PH0|rcsb pdb:1PTT|rcsb pdb:1PTU|rcsb pdb:1PTV|rcsb pdb:1PTY|rcsb pdb:1PXH|rcsb pdb:1PYN|rcsb pdb:1Q1M|rcsb pdb:1Q6J|rcsb pdb:1Q6M|rcsb pdb:1Q6N|rcsb pdb:1Q6P|rcsb pdb:1Q6S|rcsb pdb:1Q6T|rcsb pdb:1QXK|rcsb pdb:1SUG|rcsb pdb:1T48|rcsb pdb:1T49|rcsb pdb:1T4J|rcsb pdb:1WAX|rcsb pdb:1XBO|rcsb pdb:2AZR|rcsb pdb:2B07|rcsb pdb:2B4S|rcsb pdb:2BGD|rcsb pdb:2NT7|rcsb pdb:2BGE|rcsb pdb:2CM2|rcsb pdb:2NTA|rcsb pdb:2CM3|rcsb pdb:2CM7|rcsb pdb:2QBP|rcsb pdb:2CM8|rcsb pdb:2CMA|rcsb pdb:2QBQ|rcsb pdb:2QBR|rcsb pdb:2CMB|rcsb pdb:2CMC|rcsb pdb:2CNE|rcsb pdb:2QBS|rcsb pdb:2CNF|rcsb pdb:2CNG|rcsb pdb:2CNH|rcsb pdb:2CNI|rcsb pdb:2F6F|rcsb pdb:2F6T|rcsb pdb:2VEU|rcsb pdb:2F6V|rcsb pdb:2F6W|rcsb pdb:2F6Y|rcsb pdb:2VEV|rcsb pdb:2VEW|rcsb pdb:2VEX|rcsb pdb:2VEY|rcsb pdb:2F6Z|rcsb pdb:2ZMM|rcsb pdb:2F70|rcsb pdb:2F71|rcsb pdb:2ZN7|rcsb pdb:3A5J|rcsb pdb:2FJM|rcsb pdb:2FJN|rcsb pdb:2H4G|rcsb pdb:2H4K|rcsb pdb:2HB1|rcsb pdb:2HNP|rcsb pdb:2HNQ|rcsb pdb:3A5K|rcsb pdb:3CWE|rcsb pdb:6OMY|rcsb pdb:3D9C|rcsb pdb:3EAX|rcsb pdb:4QAP|rcsb pdb:4QBE|rcsb pdb:3EB1|rcsb pdb:4QBW|rcsb pdb:4Y14|rcsb pdb:4ZRT|rcsb pdb:5K9V|rcsb pdb:5K9W|rcsb pdb:5KA0|rcsb pdb:5KA1|rcsb pdb:5KA2|rcsb pdb:5KA3|rcsb pdb:5KA4|rcsb pdb:5KA7|rcsb pdb:5KA8|rcsb pdb:5KA9|rcsb pdb:5KAA|rcsb pdb:5KAB|rcsb pdb:5KAC|rcsb pdb:5KAD|rcsb pdb:5QDE|rcsb pdb:5QDF|rcsb pdb:5QDG|rcsb pdb:5QDH|rcsb pdb:5QDI|rcsb pdb:5QDJ|rcsb pdb:5QDK|rcsb pdb:5QDL|rcsb pdb:5QDM|rcsb pdb:5QDN|rcsb pdb:3EU0|rcsb pdb:3I7Z|rcsb pdb:3I80|rcsb pdb:3QKP|rcsb pdb:3QKQ|rcsb pdb:3SME|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:3ZV2|rcsb pdb:4BJO|rcsb pdb:4I8N|rcsb pdb:4QAH|rcsb pdb:5QDO|rcsb pdb:5QDP|rcsb pdb:5QDQ|rcsb pdb:5QDR|rcsb pdb:5QDS|rcsb pdb:6PG0|rcsb pdb:6PGT|rcsb pdb:6PHA|rcsb pdb:6PHS|rcsb pdb:6PM8|rcsb pdb:6W30|rcsb pdb:7KEN|rcsb pdb:7L0C|rcsb pdb:7L0H|rcsb pdb:7LFO|rcsb pdb:7MM1|reactome:R-HSA-354192|reactome:R-HSA-6807004|reactome:R-HSA-877312|reactome:R-HSA-8849472|reactome:R-HSA-9022699|reactome:R-HSA-912694|reactome:R-HSA-982772|rcsb pdb:6PFW|rcsb pdb:5QDW|rcsb pdb:5QDX|rcsb pdb:5QDY|rcsb pdb:5QDZ|rcsb pdb:5QE0|rcsb pdb:5QE1|rcsb pdb:5QDT|rcsb pdb:5QDU|rcsb pdb:5QE2|rcsb pdb:5QE3|rcsb pdb:5QE4|rcsb pdb:5QE5|rcsb pdb:5QE6|rcsb pdb:5QE7|rcsb pdb:5QE8|rcsb pdb:5QE9|rcsb pdb:5QEA|rcsb pdb:5QEB|rcsb pdb:5QEC|rcsb pdb:5QED|rcsb pdb:5QEE|rcsb pdb:5QEF|rcsb pdb:5QEG|rcsb pdb:5QEH|rcsb pdb:5QEI|rcsb pdb:5QEJ|rcsb pdb:5QDV|rcsb pdb:5QEK|rcsb pdb:5QEL|rcsb pdb:5QEM|rcsb pdb:5QEN|rcsb pdb:5QEO|rcsb pdb:5QEP|rcsb pdb:5QEQ|rcsb pdb:5QER|rcsb pdb:5QES|rcsb pdb:5QET|rcsb pdb:5QEU|rcsb pdb:5QEV|rcsb pdb:5QEW|rcsb pdb:5QEX|rcsb pdb:5QEY|rcsb pdb:5QEZ|rcsb pdb:5QF0|rcsb pdb:5QF1|rcsb pdb:5QF2|rcsb pdb:5QF3|rcsb pdb:5QF4|rcsb pdb:5QF5|rcsb pdb:5QF6|rcsb pdb:5QF7|rcsb pdb:5QF8|rcsb pdb:5QF9|rcsb pdb:5QFA|rcsb pdb:5QFB|rcsb pdb:5QFC|rcsb pdb:5QFD|rcsb pdb:5QFE|rcsb pdb:5QFF|rcsb pdb:5QFG|rcsb pdb:5QFH|rcsb pdb:5QFI|rcsb pdb:5QFJ|rcsb pdb:5QFK|rcsb pdb:5QFL|rcsb pdb:5QFM|rcsb pdb:5QFN|rcsb pdb:5QFO|rcsb pdb:5QFP|rcsb pdb:5QFQ|rcsb pdb:5QFR|rcsb pdb:5QFS|rcsb pdb:5QFT|rcsb pdb:5QFU|refseq:NP_001265547.1|refseq:NP_002818.1|dip:DIP-38014N|mint:MINT-6765237(identity)|uniprotkb:P18031(P18031)	-	function:"Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating"|comment:mint|comment:homomint	-	figure legend:F4|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/09/18	2015/06/10	rogid:GHCFRZj4WP3CoS6iZwWasF2FS3U9606	rogid:yz+WjBWu7IXrpAfeMUJ2s0e0ACM9606	intact-crc:C17492C186F4CC15|rigid:Gt+uWgTHLfnnq7ydeTsWQd4Snxw	false	necessary binding region:41-58(MINT-6785514)|yellow fluorescent protein tag:?-?(MINT-6765235)	yellow fluorescent protein tag:?-?(MINT-6765239)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)