#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q77E16	uniprotkb:Q05086	intact:EBI-7011359|intact:MINT-6732291|uniprotkb:J3XLW5	intact:EBI-954357|ensembl:ENSP00000497594|uniprotkb:P78355|uniprotkb:Q93066|uniprotkb:Q9UEP4|uniprotkb:Q9UEP5|uniprotkb:Q9UEP6|uniprotkb:Q9UEP7|uniprotkb:Q9UEP8|uniprotkb:Q9UEP9|uniprotkb:A8K8Z9	psi-mi:q77e16_hpv16(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short)	psi-mi:ube3a_human(display_long)|uniprotkb:E6AP ubiquitin-protein ligase(gene name synonym)|uniprotkb:Oncogenic protein-associated protein E6-AP(gene name synonym)|uniprotkb:Human papillomavirus E6-associated protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-54(gene name synonym)|uniprotkb:UBE3A(gene name)|psi-mi:UBE3A(display_short)|uniprotkb:E6AP(gene name synonym)|uniprotkb:EPVE6AP(gene name synonym)|uniprotkb:HPVE6A(gene name synonym)|uniprotkb:HECT-type ubiquitin transferase E3A(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Jing et al. (2007)	pubmed:17166906|mint:MINT-6549823	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7166549|mint:MINT-6732471	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR038575|interpro:IPR001334(E6 early regulatory protein)|mint:Q77E16|mint:MINT-6732472(identity)|uniprotkb:Q77E16(Q77E16)	go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060736"(prostate gland growth)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061743"(motor learning)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1905528"(positive regulation of Golgi lumen acidification)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000569(HECT)|interpro:IPR017134(Ubiquitin-protein ligase E6-AP)|interpro:IPR032353|interpro:IPR035983|interpro:IPR042556|mint:Q05086|rcsb pdb:1C4Z|rcsb pdb:1D5F|rcsb pdb:1EQX|rcsb pdb:2KR1|rcsb pdb:4GIZ|rcsb pdb:4XR8|rcsb pdb:6SJV|rcsb pdb:6SLM|rcsb pdb:6TGK|rcsb pdb:6U19|reactome:R-HSA-983168|ensembl:ENSG00000114062(gene)|ensembl:ENST00000650110(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007420"(brain development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032570"(response to progesterone)|go:"GO:0035037"(sperm entry)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|refseq:NP_000453.2|refseq:NP_570853.1|refseq:NP_570854.1|refseq:XP_016878033.1|refseq:XP_016878034.1|refseq:XP_011520296.1|refseq:XP_011520297.1|refseq:XP_016878035.1|refseq:XP_016878036.1|refseq:XP_016878037.1|refseq:XP_016878038.1|refseq:XP_016878039.1|dip:DIP-6002N|refseq:XP_005268324.1|refseq:XP_005268325.1|refseq:XP_005268326.1|refseq:XP_005268327.1|refseq:XP_005268328.1|refseq:XP_006720738.1|refseq:XP_006720739.1|refseq:XP_016878040.1|refseq:XP_016878041.1|refseq:XP_016878042.1|refseq:XP_016878043.1|refseq:XP_016878044.1|mint:MINT-6732474(identity)|uniprotkb:Q05086(Q05086)	-	comment:mint	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:2+ovpxaeWq1tFlmcUWSJ5M07anM333760	rogid:w9T67+NDlHSd1tR+FgcX3LI1zpQ9606	intact-crc:6AEF6950B1FBC3AB|rigid:hld0AoaE+MzM33Cxnrrk3x2hYIc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77E16	uniprotkb:P26045	intact:EBI-7011359|intact:MINT-6732291|uniprotkb:J3XLW5	intact:EBI-1047946|uniprotkb:A0AUW9|uniprotkb:E7EN99|uniprotkb:E9PGU7|ensembl:ENSP00000363667	psi-mi:q77e16_hpv16(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short)	psi-mi:ptn3_human(display_long)|uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym)|uniprotkb:PTPN3(gene name)|psi-mi:PTPN3(display_short)|uniprotkb:PTPH1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Jing et al. (2007)	pubmed:17166906|mint:MINT-6549823	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7166576|mint:MINT-6732478	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR038575|interpro:IPR001334(E6 early regulatory protein)|mint:Q77E16|mint:MINT-6732479(identity)|uniprotkb:Q77E16(Q77E16)	refseq:NP_001138840.1|refseq:NP_001138843.1|refseq:NP_002820.3|refseq:NP_001138841.1|refseq:NP_001138842.1|refseq:XP_011517191.1|refseq:XP_016870444.1|refseq:XP_016870446.1|ensembl:ENSG00000070159(gene)|ensembl:ENST00000374541(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051117"(ATPase binding)|go:"GO:0097421"(liver regeneration)|go:"GO:0098902"(regulation of membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:P26045|rcsb pdb:2B49|rcsb pdb:4QUM|rcsb pdb:4QUN|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4RI4|rcsb pdb:4RI5|rcsb pdb:4S0G|rcsb pdb:6HKS|rcsb pdb:6T36|reactome:R-HSA-182971|reactome:R-HSA-5675221|refseq:XP_006717262.1|refseq:XP_006717267.1|dip:DIP-38839N|mint:MINT-6732481(identity)|uniprotkb:P26045(P26045)	-	comment:mint	-	figure legend:F3|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:2+ovpxaeWq1tFlmcUWSJ5M07anM333760	rogid:7LM4ANS9aclQf1SZfn/Jmxj2fUA9606	intact-crc:832E19BD09494095|rigid:tuRvyj5wSZtQ0yHd6b0/ML5nV0w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)