#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q5M824	uniprotkb:P0DOJ9	intact:EBI-7152521|intact:UNK-5443077	intact:EBI-16746307|uniprotkb:P03076|uniprotkb:Q76TX4|uniprotkb:Q76W01|uniprotkb:Q89765	psi-mi:shc1_rat(display_long)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)	psi-mi:mt_povm1(display_long)	psi-mi:"MI:0019"(coimmunoprecipitation)	Rodriguez-Viciana et al. (2006)	pubmed:17158797|mint:MINT-6599492	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:1891730(MPyV)|taxid:1891730(Mus musculus polyomavirus 1)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7152556|mint:MINT-6628763	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q5M824|interpro:IPR029586|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010008"(endosome membrane)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035094"(response to nicotine)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-RNO-1250347|reactome:R-RNO-167044|reactome:R-RNO-180336|reactome:R-RNO-210993|reactome:R-RNO-2424491|reactome:R-RNO-2428933|reactome:R-RNO-2730905|reactome:R-RNO-2871796|reactome:R-RNO-2871809|reactome:R-RNO-354192|reactome:R-RNO-512988|reactome:R-RNO-5654688|reactome:R-RNO-5654699|reactome:R-RNO-5654704|reactome:R-RNO-5654719|reactome:R-RNO-5673001|reactome:R-RNO-74749|reactome:R-RNO-1250196|reactome:R-RNO-74751|reactome:R-RNO-8851805|reactome:R-RNO-8853659|reactome:R-RNO-8983432|reactome:R-RNO-9009391|reactome:R-RNO-9020558|reactome:R-RNO-9027284|reactome:R-RNO-912526|reactome:R-RNO-9674555|interpro:IPR011993(Pleckstrin homology-type)|rgd:620446|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|refseq:NP_445969.2|interpro:IPR000980(SH2 motif)|interpro:IPR035676|interpro:IPR036860|mint:MINT-6628766(identity)|uniprotkb:Q5M824(Q5M824)	go:"GO:0016021"(integral component of membrane)|go:"GO:0033644"(host cell membrane)|mint:P0DOJ9|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003354(Small/middle T-antigen)|interpro:IPR036092|interpro:IPR036869|mint:MINT-6628764(identity)|uniprotkb:P03076(P03076)	-	comment:mint	-	figure legend:F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:10116(rat-ref52)|taxid:10116(Rattus norvegicus embryonic fibroblast cells)	-	2008/06/26	2018/01/22	rogid:MjscQEdZttIGMDyqfEUijAfBmaA10116	rogid:aJ9cGyI4HnzoWwWLFVUSytN50Lo1891730	intact-crc:AB7ECDAA6C681921|rigid:+VK5DqCri/Blzsn+vTEAAn0d1/w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P63331	uniprotkb:P0DOJ9	intact:EBI-7050205|ensembl:ENSRNOP00000007621|ensembl:ENSRNOP00000071286|intact:MINT-199689|uniprotkb:O88591|uniprotkb:P13353	intact:EBI-16746307|uniprotkb:P03076|uniprotkb:Q76TX4|uniprotkb:Q76W01|uniprotkb:Q89765	psi-mi:pp2aa_rat(display_long)|uniprotkb:Ppp2ca(gene name)|psi-mi:Ppp2ca(display_short)	psi-mi:mt_povm1(display_long)	psi-mi:"MI:0019"(coimmunoprecipitation)	Rodriguez-Viciana et al. (2006)	pubmed:17158797|mint:MINT-6599492	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:1891730(MPyV)|taxid:1891730(Mus musculus polyomavirus 1)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7152622|mint:MINT-6628773	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008772116.1|ensembl:ENSRNOG00000005389(gene)|ensembl:ENSRNOG00000056485(gene)|ensembl:ENSRNOT00000007621(transcript)|ensembl:ENSRNOT00000079985(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1990405"(protein antigen binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|reactome:R-RNO-1295596|reactome:R-RNO-141444|reactome:R-RNO-180024|reactome:R-RNO-195253|reactome:R-RNO-196299|reactome:R-RNO-198753|reactome:R-RNO-202670|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-2995383|reactome:R-RNO-389513|reactome:R-RNO-4641262|reactome:R-RNO-5663220|reactome:R-RNO-5673000|reactome:R-RNO-5675221|reactome:R-RNO-6804757|reactome:R-RNO-6811558|reactome:R-RNO-68877|reactome:R-RNO-69231|reactome:R-RNO-69273|reactome:R-RNO-9648025|reactome:R-RNO-975957|mint:P63331|reactome:R-RNO-113501|refseq:NP_058735.1|rgd:3380|mint:MINT-6628776(identity)|uniprotkb:P63331(P63331)	go:"GO:0016021"(integral component of membrane)|go:"GO:0033644"(host cell membrane)|mint:P0DOJ9|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003354(Small/middle T-antigen)|interpro:IPR036092|interpro:IPR036869|mint:MINT-6628774(identity)|uniprotkb:P03076(P03076)	-	function:PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase|comment:mint|comment:homomint	-	figure legend:F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:10116(rat-ref52)|taxid:10116(Rattus norvegicus embryonic fibroblast cells)	-	2008/06/26	2018/01/22	rogid:gpR5Fal3vi6O6cteeGwW72EuctY10116	rogid:aJ9cGyI4HnzoWwWLFVUSytN50Lo1891730	intact-crc:350B8308FCC0E797|rigid:SOjgE43PBOeV6/p+w4wk8HLMwSI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q4QQT4	uniprotkb:P0DOJ9	intact:EBI-7152576|ensembl:ENSRNOP00000059428|intact:UNK-5426275	intact:EBI-16746307|uniprotkb:P03076|uniprotkb:Q76TX4|uniprotkb:Q76W01|uniprotkb:Q89765	psi-mi:2aab_rat(display_long)|uniprotkb:PP2A subunit A isoform R1-beta(gene name synonym)|uniprotkb:PP2A subunit A isoform PR65-beta(gene name synonym)|uniprotkb:Ppp2r1b(gene name)|psi-mi:Ppp2r1b(display_short)	psi-mi:mt_povm1(display_long)	psi-mi:"MI:0019"(coimmunoprecipitation)	Rodriguez-Viciana et al. (2006)	pubmed:17158797|mint:MINT-6599492	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:1891730(MPyV)|taxid:1891730(Mus musculus polyomavirus 1)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7152569|mint:MINT-6628768	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000010922(gene)|ensembl:ENSRNOT00000064290(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|mint:Q4QQT4|reactome:R-RNO-113501|reactome:R-RNO-141444|reactome:R-RNO-180024|reactome:R-RNO-195253|reactome:R-RNO-196299|reactome:R-RNO-198753|reactome:R-RNO-202670|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-389513|reactome:R-RNO-4641262|reactome:R-RNO-5663220|reactome:R-RNO-5673000|reactome:R-RNO-5675221|reactome:R-RNO-6804757|reactome:R-RNO-6811558|reactome:R-RNO-68877|reactome:R-RNO-69231|reactome:R-RNO-69273|reactome:R-RNO-9648025|rgd:1304764|refseq:NP_001020589.1|mint:MINT-6628771(identity)|uniprotkb:Q4QQT4(Q4QQT4)	go:"GO:0016021"(integral component of membrane)|go:"GO:0033644"(host cell membrane)|mint:P0DOJ9|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003354(Small/middle T-antigen)|interpro:IPR036092|interpro:IPR036869|mint:MINT-6628769(identity)|uniprotkb:P03076(P03076)	-	function:The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit|comment:mint	-	figure legend:F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:10116(rat-ref52)|taxid:10116(Rattus norvegicus embryonic fibroblast cells)	-	2008/06/26	2018/01/22	rogid:ayq8HKJeRrRHxa93NOIiP4zoXA810116	rogid:aJ9cGyI4HnzoWwWLFVUSytN50Lo1891730	intact-crc:33F754F2D40FA95E|rigid:RMBv/lBNR0oooNScnn+OysCxiBI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)