#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q69ZI1	uniprotkb:Q9Z2F7	intact:EBI-957380|uniprotkb:Q3UG42|uniprotkb:Q6P9M8|uniprotkb:Q8BR66|uniprotkb:Q8C2T5|uniprotkb:O70254	intact:EBI-1774669|uniprotkb:Q545J6|ensembl:ENSMUSP00000022634	psi-mi:sh3r1_mouse(display_long)|uniprotkb:Posh1(gene name synonym)|uniprotkb:Sh3rf1(gene name)|psi-mi:Sh3rf1(display_short)|uniprotkb:Kiaa1494(gene name synonym)|uniprotkb:Posh(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:SH3 multiple domains protein 2(gene name synonym)|uniprotkb:Sh3md2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym)	psi-mi:bni3l_mouse(display_long)|uniprotkb:Bnip3l(gene name)|psi-mi:Bnip3l(display_short)|uniprotkb:Nix(gene name synonym)|uniprotkb:NIP3-like protein X(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wilhelm et al. (2007)	pubmed:17095503|imex:IM-18906	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1774643|imex:IM-18906-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067481.2|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030027"(lamellipodium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013424|interpro:IPR035795|interpro:IPR035816|interpro:IPR036028|reactome:R-MMU-983168	refseq:NP_033891.1|ensembl:ENSMUSG00000022051(gene)|ensembl:ENSMUST00000022634(transcript)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|interpro:IPR010548(BNIP3)|reactome:R-MMU-6803204|go:"GO:0043067"(regulation of programmed cell death)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/05/19	2014/10/16	rogid:IlJ8Jo/3jz3+wqZGb++Bgb5pkWk10090	rogid:wQkRnzfVmNA02h0JmMe3cKmhJaI10090	intact-crc:C751459FF12EA6D0|rigid:6yZ5n0tvt2Jt/j9zCeU4rqGWVG4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z2F7	uniprotkb:Q69ZI1	intact:EBI-1774669|uniprotkb:Q545J6|ensembl:ENSMUSP00000022634	intact:EBI-957380|uniprotkb:Q3UG42|uniprotkb:Q6P9M8|uniprotkb:Q8BR66|uniprotkb:Q8C2T5|uniprotkb:O70254	psi-mi:bni3l_mouse(display_long)|uniprotkb:Bnip3l(gene name)|psi-mi:Bnip3l(display_short)|uniprotkb:Nix(gene name synonym)|uniprotkb:NIP3-like protein X(gene name synonym)	psi-mi:sh3r1_mouse(display_long)|uniprotkb:Posh1(gene name synonym)|uniprotkb:Sh3rf1(gene name)|psi-mi:Sh3rf1(display_short)|uniprotkb:Kiaa1494(gene name synonym)|uniprotkb:Posh(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:SH3 multiple domains protein 2(gene name synonym)|uniprotkb:Sh3md2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wilhelm et al. (2007)	pubmed:17095503|imex:IM-18906	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1774690|imex:IM-18906-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033891.1|ensembl:ENSMUSG00000022051(gene)|ensembl:ENSMUST00000022634(transcript)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|interpro:IPR010548(BNIP3)|reactome:R-MMU-6803204|go:"GO:0043067"(regulation of programmed cell death)	refseq:NP_067481.2|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030027"(lamellipodium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013424|interpro:IPR035795|interpro:IPR035816|interpro:IPR036028|reactome:R-MMU-983168	-	-	-	figure legend:1 A|comment:"The Sh3rf1 (POSH) construct had the Zinc finger domain deleted to enhance protein stability while retaining the ability to activate the JNK pathway."|delivery method:O70254; Q9Z2F7 transfection|caution:"As the coordinates for the Zn finger domain deleted from Sh3rf1 (POSH) are taken from a paper by different authors, these are given as fuzzy coordinates."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/05/19	2014/10/16	rogid:wQkRnzfVmNA02h0JmMe3cKmhJaI10090	rogid:IlJ8Jo/3jz3+wqZGb++Bgb5pkWk10090	intact-crc:9A69558D284A6608|rigid:6yZ5n0tvt2Jt/j9zCeU4rqGWVG4	false	flag tag:?-?	myc tag:?-?|sufficient binding region:83..83-892,1-17..17	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q69ZI1	uniprotkb:Q9Z2F7	intact:EBI-957380|uniprotkb:Q3UG42|uniprotkb:Q6P9M8|uniprotkb:Q8BR66|uniprotkb:Q8C2T5|uniprotkb:O70254	intact:EBI-1774669|uniprotkb:Q545J6|ensembl:ENSMUSP00000022634	psi-mi:sh3r1_mouse(display_long)|uniprotkb:Posh1(gene name synonym)|uniprotkb:Sh3rf1(gene name)|psi-mi:Sh3rf1(display_short)|uniprotkb:Kiaa1494(gene name synonym)|uniprotkb:Posh(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:SH3 multiple domains protein 2(gene name synonym)|uniprotkb:Sh3md2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym)	psi-mi:bni3l_mouse(display_long)|uniprotkb:Bnip3l(gene name)|psi-mi:Bnip3l(display_short)|uniprotkb:Nix(gene name synonym)|uniprotkb:NIP3-like protein X(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wilhelm et al. (2007)	pubmed:17095503|imex:IM-18906	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1774789|imex:IM-18906-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067481.2|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030027"(lamellipodium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013424|interpro:IPR035795|interpro:IPR035816|interpro:IPR036028|reactome:R-MMU-983168	refseq:NP_033891.1|ensembl:ENSMUSG00000022051(gene)|ensembl:ENSMUST00000022634(transcript)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|interpro:IPR010548(BNIP3)|reactome:R-MMU-6803204|go:"GO:0043067"(regulation of programmed cell death)	-	-	-	figure legend:1 B|comment:"The Sh3rf1 (POSH) construct had the Zinc finger domain deleted to enhance protein stability while retaining the ability to activate the JNK pathway."|delivery method:O70254; Q9Z2F7 transfection|caution:"As the coordinates for the Zn finger domain deleted from Sh3rf1 (POSH) are taken from a paper by different authors, these are given as fuzzy coordinates."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/05/19	2014/10/16	rogid:IlJ8Jo/3jz3+wqZGb++Bgb5pkWk10090	rogid:wQkRnzfVmNA02h0JmMe3cKmhJaI10090	intact-crc:2C4EB254539B3B6E|rigid:6yZ5n0tvt2Jt/j9zCeU4rqGWVG4	false	myc tag:?-?|sufficient binding region:83..83-892,1-17..17	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Z2F7	uniprotkb:Q69ZI1	intact:EBI-1774669|uniprotkb:Q545J6|ensembl:ENSMUSP00000022634	intact:EBI-957380|uniprotkb:Q3UG42|uniprotkb:Q6P9M8|uniprotkb:Q8BR66|uniprotkb:Q8C2T5|uniprotkb:O70254	psi-mi:bni3l_mouse(display_long)|uniprotkb:Bnip3l(gene name)|psi-mi:Bnip3l(display_short)|uniprotkb:Nix(gene name synonym)|uniprotkb:NIP3-like protein X(gene name synonym)	psi-mi:sh3r1_mouse(display_long)|uniprotkb:Posh1(gene name synonym)|uniprotkb:Sh3rf1(gene name)|psi-mi:Sh3rf1(display_short)|uniprotkb:Kiaa1494(gene name synonym)|uniprotkb:Posh(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:SH3 multiple domains protein 2(gene name synonym)|uniprotkb:Sh3md2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wilhelm et al. (2007)	pubmed:17095503|imex:IM-18906	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1774810|imex:IM-18906-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033891.1|ensembl:ENSMUSG00000022051(gene)|ensembl:ENSMUST00000022634(transcript)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|interpro:IPR010548(BNIP3)|reactome:R-MMU-6803204|go:"GO:0043067"(regulation of programmed cell death)	refseq:NP_067481.2|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030027"(lamellipodium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013424|interpro:IPR035795|interpro:IPR035816|interpro:IPR036028|reactome:R-MMU-983168	-	-	-	figure legend:1 C|comment:"Sh3rf1 (POSH) also bound to a naturally occurring dominant-negative isoform of Bnip3l (Nix), sNix, (which lacks only the terminal 10 amino acids of the protein and unlike Bnip3l, is not targeted to mitochondrial membranes) and Bnip3l lacking the BH3 domain."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/05/19	2014/10/16	rogid:wQkRnzfVmNA02h0JmMe3cKmhJaI10090	rogid:IlJ8Jo/3jz3+wqZGb++Bgb5pkWk10090	intact-crc:5965FBD8C14455BB|rigid:6yZ5n0tvt2Jt/j9zCeU4rqGWVG4	false	35s radiolabel:?-?|sufficient binding region:1-208|sufficient binding region:141-218,1-132	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)