#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04015	uniprotkb:O60885	intact:EBI-7010556|intact:MINT-95651	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Sénéchal et al. (2007)	pubmed:17023018|mint:MINT-6549876	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7010577|mint:MINT-6733813	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-6733814(identity)|uniprotkb:P04015(P04015)	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N|mint:MINT-6733817(identity)|uniprotkb:O60885(O60885)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:D8A5AD80E9D65711|rigid:B7cyy8rQXeRMuPvK9ghUcRI4ryA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17383	uniprotkb:O60885	intact:EBI-7010529|intact:MINT-6732762	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_hpv31(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Sénéchal et al. (2007)	pubmed:17023018|mint:MINT-6549876	taxid:10585(hpv31)|taxid:10585(Human papillomavirus type 31)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7010522|mint:MINT-6733806	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1A7G|rcsb pdb:1DHM|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|mint:P17383|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-6733810(identity)|uniprotkb:P17383(P17383)	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N|mint:MINT-6733807(identity)|uniprotkb:O60885(O60885)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:61w6hPmtaoXazA4sMj+nF22iBek10585	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:6C7A366CDF194816|rigid:HKs4P/R+xecywZMuu30iGPesP4U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60885	uniprotkb:P03120	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	intact:EBI-1779322|uniprotkb:Q71BI4	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Sénéchal et al. (2007)	pubmed:17023018|mint:MINT-6549876	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7010616|mint:MINT-6733834	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N|mint:MINT-6733838(identity)|uniprotkb:O60885(O60885)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7|mint:MINT-6733835(identity)|uniprotkb:P03120(P03120)	-	-	-	figure legend:F3  F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	intact-crc:31C190C40C1BD1D6|rigid:NtNiOCyD5LQ1Cpz/GbGFpiDtakI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17383	uniprotkb:O60885	intact:EBI-7010529|intact:MINT-6732762	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_hpv31(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Sénéchal et al. (2007)	pubmed:17023018|mint:MINT-6549876	taxid:10585(hpv31)|taxid:10585(Human papillomavirus type 31)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7010590|mint:MINT-6733820	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1A7G|rcsb pdb:1DHM|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|mint:P17383|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-6733821(identity)|uniprotkb:P17383(P17383)	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N|mint:MINT-6733824(identity)|uniprotkb:O60885(O60885)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:F3  F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:61w6hPmtaoXazA4sMj+nF22iBek10585	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:544BEB2B491F7764|rigid:HKs4P/R+xecywZMuu30iGPesP4U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:O60885	intact:EBI-7010556|intact:MINT-95651	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Sénéchal et al. (2007)	pubmed:17023018|mint:MINT-6549876	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7010603|mint:MINT-6733827	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-6733831(identity)|uniprotkb:P04015(P04015)	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N|mint:MINT-6733828(identity)|uniprotkb:O60885(O60885)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:F3  F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:E09B3B940C1BD1B2|rigid:B7cyy8rQXeRMuPvK9ghUcRI4ryA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03121	uniprotkb:O60885	intact:EBI-7010715|intact:MINT-6732781	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_crpvk(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Sénéchal et al. (2007)	pubmed:17023018|mint:MINT-6549876	taxid:31553(crpvk)|taxid:31553("Cottontail rabbit papillomavirus (strain Kansas)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7010734|mint:MINT-6733855	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P03121|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-6733856(identity)|uniprotkb:P03121(P03121)	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N|mint:MINT-6733859(identity)|uniprotkb:O60885(O60885)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:F3  F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:iClPiDKEc+8Rfe1fmFnJTNXlHao31553	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:DBA0B5AE54A94466|rigid:Ih/4PF2mgk87UpRaojqnZcnSc+s	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11298	uniprotkb:O60885	intact:EBI-7010673|intact:MINT-6732772	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve1_bpv2(display_long)|uniprotkb:E1(gene name)|psi-mi:E1(display_short)|uniprotkb:ATP-dependent helicase E1(gene name synonym)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Sénéchal et al. (2007)	pubmed:17023018|mint:MINT-6549876	taxid:2758382(bpv2)|taxid:2758382(Bovine papillomavirus type 2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7010666|mint:MINT-6733848	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR016393(Replication protein E1, papillomavirus)|interpro:IPR001177(DNA helicase E1 protein, C-terminal, Papillomavirus)|interpro:IPR027417|interpro:IPR014000(DNA helicase E1 protein, N-terminal, Papillomavirus)|mint:P11298|mint:MINT-6733852(identity)|uniprotkb:P11298(P11298)	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N|mint:MINT-6733849(identity)|uniprotkb:O60885(O60885)	-	comment:mint|function:ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins	-	figure legend:F3  F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:kXDv/dUdIk8osFqL0I6PJaQzFnk2758382	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:FB635033AA914C68|rigid:pkQsRcjQnHn2UOF3zarJPaiPSy4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:O60885	intact:EBI-7010629|intact:MINT-95532	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Sénéchal et al. (2007)	pubmed:17023018|mint:MINT-6549876	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7010653|mint:MINT-6733841	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-6733845(identity)|uniprotkb:P06790(P06790)	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N|mint:MINT-6733842(identity)|uniprotkb:O60885(O60885)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:F3  F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:0C63D94CEF9502DB|rigid:DUBIji5ypPZNS9nT3lFDeDRjIOg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)