#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9NYA1	uniprotkb:Q14192	intact:EBI-985303|uniprotkb:Q8N632|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726|uniprotkb:Q9HD92|uniprotkb:Q9NY70|uniprotkb:Q9NYL3|uniprotkb:Q96GK1	intact:EBI-701903|ensembl:ENSP00000322909|ensembl:ENSP00000344266|ensembl:ENSP00000377020|ensembl:ENSP00000377021|ensembl:ENSP00000386633|ensembl:ENSP00000386665|ensembl:ENSP00000386892|ensembl:ENSP00000433567|uniprotkb:Q13229|uniprotkb:Q13644|uniprotkb:Q9P294|uniprotkb:Q2I5I4|uniprotkb:Q5TM15	psi-mi:sphk1_human(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPK(gene name synonym)	psi-mi:fhl2_human(display_long)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)|uniprotkb:LIM domain protein DRAL(gene name synonym)|uniprotkb:FHL2(gene name)|psi-mi:FHL2(display_short)|uniprotkb:DRAL(gene name synonym)|uniprotkb:SLIM3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sun et al. (2006)	pubmed:16888242|imex:IM-20024	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1748236|imex:IM-20024-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001568"(blood vessel development)|go:"GO:0001727"(lipid kinase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006473"(protein acetylation)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0008289"(lipid binding)|go:"GO:0008481"(sphinganine kinase activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0017050"(D-erythro-sphingosine kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046521"(sphingoid catabolic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0098793"(presynapse)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1905364"(regulation of endosomal vesicle fusion)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|mint:Q9NYA1|rcsb pdb:3VZB|rcsb pdb:3VZC|rcsb pdb:3VZD|rcsb pdb:4L02|rcsb pdb:4V24|reactome:R-HSA-1660661|reactome:R-HSA-390471|reactome:R-HSA-5218921|reactome:R-HSA-9009391|refseq:XP_005257823.1|refseq:NP_001136073.1|refseq:NP_001136074.1|refseq:NP_068807.2|refseq:NP_892010.2	ensembl:ENSG00000115641(gene)|ensembl:ENST00000322142(transcript)|ensembl:ENST00000344213(transcript)|ensembl:ENST00000393352(transcript)|ensembl:ENST00000393353(transcript)|ensembl:ENST00000408995(transcript)|ensembl:ENST00000409177(transcript)|ensembl:ENST00000409807(transcript)|ensembl:ENST00000530340(transcript)|refseq:NP_001034581.1|refseq:NP_001441.4|refseq:NP_963849.1|refseq:NP_963851.2|refseq:NP_001305823.1|refseq:NP_001305824.1|refseq:NP_001305825.1|refseq:NP_001305826.1|refseq:XP_011509100.1|dip:DIP-5980N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|mint:Q14192|rcsb pdb:1X4K|rcsb pdb:1X4L|rcsb pdb:2D8Z|rcsb pdb:2MIU|reactome:R-HSA-1989781	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/03/25	2014/10/16	rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606	rogid:4X5kI037ASzuT1zACXH89BkwDBk9606	intact-crc:7BB5AB792A36972A|rigid:92VCrKuTa+DsinqdQS2k7vh5VOY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NYA1	uniprotkb:Q14192	intact:EBI-985303|uniprotkb:Q8N632|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726|uniprotkb:Q9HD92|uniprotkb:Q9NY70|uniprotkb:Q9NYL3|uniprotkb:Q96GK1	intact:EBI-701903|ensembl:ENSP00000322909|ensembl:ENSP00000344266|ensembl:ENSP00000377020|ensembl:ENSP00000377021|ensembl:ENSP00000386633|ensembl:ENSP00000386665|ensembl:ENSP00000386892|ensembl:ENSP00000433567|uniprotkb:Q13229|uniprotkb:Q13644|uniprotkb:Q9P294|uniprotkb:Q2I5I4|uniprotkb:Q5TM15	psi-mi:sphk1_human(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPK(gene name synonym)	psi-mi:fhl2_human(display_long)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)|uniprotkb:LIM domain protein DRAL(gene name synonym)|uniprotkb:FHL2(gene name)|psi-mi:FHL2(display_short)|uniprotkb:DRAL(gene name synonym)|uniprotkb:SLIM3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sun et al. (2006)	pubmed:16888242|imex:IM-20024	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1748246|imex:IM-20024-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001568"(blood vessel development)|go:"GO:0001727"(lipid kinase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006473"(protein acetylation)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0008289"(lipid binding)|go:"GO:0008481"(sphinganine kinase activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0017050"(D-erythro-sphingosine kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046521"(sphingoid catabolic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0098793"(presynapse)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1905364"(regulation of endosomal vesicle fusion)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|mint:Q9NYA1|rcsb pdb:3VZB|rcsb pdb:3VZC|rcsb pdb:3VZD|rcsb pdb:4L02|rcsb pdb:4V24|reactome:R-HSA-1660661|reactome:R-HSA-390471|reactome:R-HSA-5218921|reactome:R-HSA-9009391|refseq:XP_005257823.1|refseq:NP_001136073.1|refseq:NP_001136074.1|refseq:NP_068807.2|refseq:NP_892010.2	ensembl:ENSG00000115641(gene)|ensembl:ENST00000322142(transcript)|ensembl:ENST00000344213(transcript)|ensembl:ENST00000393352(transcript)|ensembl:ENST00000393353(transcript)|ensembl:ENST00000408995(transcript)|ensembl:ENST00000409177(transcript)|ensembl:ENST00000409807(transcript)|ensembl:ENST00000530340(transcript)|refseq:NP_001034581.1|refseq:NP_001441.4|refseq:NP_963849.1|refseq:NP_963851.2|refseq:NP_001305823.1|refseq:NP_001305824.1|refseq:NP_001305825.1|refseq:NP_001305826.1|refseq:XP_011509100.1|dip:DIP-5980N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|mint:Q14192|rcsb pdb:1X4K|rcsb pdb:1X4L|rcsb pdb:2D8Z|rcsb pdb:2MIU|reactome:R-HSA-1989781	-	-	-	figure legend:1 A, C, D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/03/25	2014/10/16	rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606	rogid:4X5kI037ASzuT1zACXH89BkwDBk9606	intact-crc:9402646763AC4318|rigid:92VCrKuTa+DsinqdQS2k7vh5VOY	false	sufficient binding region:135-298	sufficient binding region:35-279(IPR001781)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NYA1	uniprotkb:Q14192	intact:EBI-985303|uniprotkb:Q8N632|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726|uniprotkb:Q9HD92|uniprotkb:Q9NY70|uniprotkb:Q9NYL3|uniprotkb:Q96GK1	intact:EBI-701903|ensembl:ENSP00000322909|ensembl:ENSP00000344266|ensembl:ENSP00000377020|ensembl:ENSP00000377021|ensembl:ENSP00000386633|ensembl:ENSP00000386665|ensembl:ENSP00000386892|ensembl:ENSP00000433567|uniprotkb:Q13229|uniprotkb:Q13644|uniprotkb:Q9P294|uniprotkb:Q2I5I4|uniprotkb:Q5TM15	psi-mi:sphk1_human(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPK(gene name synonym)	psi-mi:fhl2_human(display_long)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)|uniprotkb:LIM domain protein DRAL(gene name synonym)|uniprotkb:FHL2(gene name)|psi-mi:FHL2(display_short)|uniprotkb:DRAL(gene name synonym)|uniprotkb:SLIM3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sun et al. (2006)	pubmed:16888242|imex:IM-20024	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1748258|imex:IM-20024-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001568"(blood vessel development)|go:"GO:0001727"(lipid kinase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006473"(protein acetylation)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0008289"(lipid binding)|go:"GO:0008481"(sphinganine kinase activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0017050"(D-erythro-sphingosine kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046521"(sphingoid catabolic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0098793"(presynapse)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1905364"(regulation of endosomal vesicle fusion)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|mint:Q9NYA1|rcsb pdb:3VZB|rcsb pdb:3VZC|rcsb pdb:3VZD|rcsb pdb:4L02|rcsb pdb:4V24|reactome:R-HSA-1660661|reactome:R-HSA-390471|reactome:R-HSA-5218921|reactome:R-HSA-9009391|refseq:XP_005257823.1|refseq:NP_001136073.1|refseq:NP_001136074.1|refseq:NP_068807.2|refseq:NP_892010.2	ensembl:ENSG00000115641(gene)|ensembl:ENST00000322142(transcript)|ensembl:ENST00000344213(transcript)|ensembl:ENST00000393352(transcript)|ensembl:ENST00000393353(transcript)|ensembl:ENST00000408995(transcript)|ensembl:ENST00000409177(transcript)|ensembl:ENST00000409807(transcript)|ensembl:ENST00000530340(transcript)|refseq:NP_001034581.1|refseq:NP_001441.4|refseq:NP_963849.1|refseq:NP_963851.2|refseq:NP_001305823.1|refseq:NP_001305824.1|refseq:NP_001305825.1|refseq:NP_001305826.1|refseq:XP_011509100.1|dip:DIP-5980N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|mint:Q14192|rcsb pdb:1X4K|rcsb pdb:1X4L|rcsb pdb:2D8Z|rcsb pdb:2MIU|reactome:R-HSA-1989781	-	-	-	figure legend:1 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2008/03/25	2014/10/16	rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606	rogid:4X5kI037ASzuT1zACXH89BkwDBk9606	intact-crc:7D9131329CD36501|rigid:92VCrKuTa+DsinqdQS2k7vh5VOY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NYA1	uniprotkb:Q14192	intact:EBI-985303|uniprotkb:Q8N632|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726|uniprotkb:Q9HD92|uniprotkb:Q9NY70|uniprotkb:Q9NYL3|uniprotkb:Q96GK1	intact:EBI-701903|ensembl:ENSP00000322909|ensembl:ENSP00000344266|ensembl:ENSP00000377020|ensembl:ENSP00000377021|ensembl:ENSP00000386633|ensembl:ENSP00000386665|ensembl:ENSP00000386892|ensembl:ENSP00000433567|uniprotkb:Q13229|uniprotkb:Q13644|uniprotkb:Q9P294|uniprotkb:Q2I5I4|uniprotkb:Q5TM15	psi-mi:sphk1_human(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPK(gene name synonym)	psi-mi:fhl2_human(display_long)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)|uniprotkb:LIM domain protein DRAL(gene name synonym)|uniprotkb:FHL2(gene name)|psi-mi:FHL2(display_short)|uniprotkb:DRAL(gene name synonym)|uniprotkb:SLIM3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2006)	pubmed:16888242|imex:IM-20024	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1748323|imex:IM-20024-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001568"(blood vessel development)|go:"GO:0001727"(lipid kinase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006473"(protein acetylation)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0008289"(lipid binding)|go:"GO:0008481"(sphinganine kinase activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0017050"(D-erythro-sphingosine kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046521"(sphingoid catabolic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0098793"(presynapse)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1905364"(regulation of endosomal vesicle fusion)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|mint:Q9NYA1|rcsb pdb:3VZB|rcsb pdb:3VZC|rcsb pdb:3VZD|rcsb pdb:4L02|rcsb pdb:4V24|reactome:R-HSA-1660661|reactome:R-HSA-390471|reactome:R-HSA-5218921|reactome:R-HSA-9009391|refseq:XP_005257823.1|refseq:NP_001136073.1|refseq:NP_001136074.1|refseq:NP_068807.2|refseq:NP_892010.2	ensembl:ENSG00000115641(gene)|ensembl:ENST00000322142(transcript)|ensembl:ENST00000344213(transcript)|ensembl:ENST00000393352(transcript)|ensembl:ENST00000393353(transcript)|ensembl:ENST00000408995(transcript)|ensembl:ENST00000409177(transcript)|ensembl:ENST00000409807(transcript)|ensembl:ENST00000530340(transcript)|refseq:NP_001034581.1|refseq:NP_001441.4|refseq:NP_963849.1|refseq:NP_963851.2|refseq:NP_001305823.1|refseq:NP_001305824.1|refseq:NP_001305825.1|refseq:NP_001305826.1|refseq:XP_011509100.1|dip:DIP-5980N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|mint:Q14192|rcsb pdb:1X4K|rcsb pdb:1X4L|rcsb pdb:2D8Z|rcsb pdb:2MIU|reactome:R-HSA-1989781	-	-	-	figure legend:2 A, C|delivery method:Q14192; Q9NYA1 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/03/25	2014/10/16	rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606	rogid:4X5kI037ASzuT1zACXH89BkwDBk9606	intact-crc:8CFC61B26C460F6D|rigid:92VCrKuTa+DsinqdQS2k7vh5VOY	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NYA1	uniprotkb:Q14192	intact:EBI-985303|uniprotkb:Q8N632|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726|uniprotkb:Q9HD92|uniprotkb:Q9NY70|uniprotkb:Q9NYL3|uniprotkb:Q96GK1	intact:EBI-701903|ensembl:ENSP00000322909|ensembl:ENSP00000344266|ensembl:ENSP00000377020|ensembl:ENSP00000377021|ensembl:ENSP00000386633|ensembl:ENSP00000386665|ensembl:ENSP00000386892|ensembl:ENSP00000433567|uniprotkb:Q13229|uniprotkb:Q13644|uniprotkb:Q9P294|uniprotkb:Q2I5I4|uniprotkb:Q5TM15	psi-mi:sphk1_human(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPK(gene name synonym)	psi-mi:fhl2_human(display_long)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)|uniprotkb:LIM domain protein DRAL(gene name synonym)|uniprotkb:FHL2(gene name)|psi-mi:FHL2(display_short)|uniprotkb:DRAL(gene name synonym)|uniprotkb:SLIM3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2006)	pubmed:16888242|imex:IM-20024	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1748333|imex:IM-20024-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001568"(blood vessel development)|go:"GO:0001727"(lipid kinase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006473"(protein acetylation)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0008289"(lipid binding)|go:"GO:0008481"(sphinganine kinase activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0017050"(D-erythro-sphingosine kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046521"(sphingoid catabolic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0098793"(presynapse)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1905364"(regulation of endosomal vesicle fusion)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|mint:Q9NYA1|rcsb pdb:3VZB|rcsb pdb:3VZC|rcsb pdb:3VZD|rcsb pdb:4L02|rcsb pdb:4V24|reactome:R-HSA-1660661|reactome:R-HSA-390471|reactome:R-HSA-5218921|reactome:R-HSA-9009391|refseq:XP_005257823.1|refseq:NP_001136073.1|refseq:NP_001136074.1|refseq:NP_068807.2|refseq:NP_892010.2	ensembl:ENSG00000115641(gene)|ensembl:ENST00000322142(transcript)|ensembl:ENST00000344213(transcript)|ensembl:ENST00000393352(transcript)|ensembl:ENST00000393353(transcript)|ensembl:ENST00000408995(transcript)|ensembl:ENST00000409177(transcript)|ensembl:ENST00000409807(transcript)|ensembl:ENST00000530340(transcript)|refseq:NP_001034581.1|refseq:NP_001441.4|refseq:NP_963849.1|refseq:NP_963851.2|refseq:NP_001305823.1|refseq:NP_001305824.1|refseq:NP_001305825.1|refseq:NP_001305826.1|refseq:XP_011509100.1|dip:DIP-5980N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|mint:Q14192|rcsb pdb:1X4K|rcsb pdb:1X4L|rcsb pdb:2D8Z|rcsb pdb:2MIU|reactome:R-HSA-1989781	-	-	-	figure legend:2 A, 4|delivery method:Q14192; Q9NYA1 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/03/25	2014/10/16	rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606	rogid:4X5kI037ASzuT1zACXH89BkwDBk9606	intact-crc:DA5BE18059EEE9CB|rigid:92VCrKuTa+DsinqdQS2k7vh5VOY	false	flag tag:?-?	myc tag:?-?|sufficient binding region:35-279(IPR001781)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NRA0	uniprotkb:Q14192	intact:EBI-985324|uniprotkb:Q9BRN1|uniprotkb:Q9H0Q2|uniprotkb:Q9NWU7|uniprotkb:B4DU87|uniprotkb:A0T4C8|ensembl:ENSP00000245222|ensembl:ENSP00000469158	intact:EBI-701903|ensembl:ENSP00000322909|ensembl:ENSP00000344266|ensembl:ENSP00000377020|ensembl:ENSP00000377021|ensembl:ENSP00000386633|ensembl:ENSP00000386665|ensembl:ENSP00000386892|ensembl:ENSP00000433567|uniprotkb:Q13229|uniprotkb:Q13644|uniprotkb:Q9P294|uniprotkb:Q2I5I4|uniprotkb:Q5TM15	psi-mi:sphk2_human(display_long)|uniprotkb:SPHK2(gene name)|psi-mi:SPHK2(display_short)|uniprotkb:SK2(gene name synonym)	psi-mi:fhl2_human(display_long)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)|uniprotkb:LIM domain protein DRAL(gene name synonym)|uniprotkb:FHL2(gene name)|psi-mi:FHL2(display_short)|uniprotkb:DRAL(gene name synonym)|uniprotkb:SLIM3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2006)	pubmed:16888242|imex:IM-20024	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1748370|imex:IM-20024-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011525435.1|refseq:XP_011525436.1|refseq:XP_006723355.1|refseq:NP_001191088.1|refseq:NP_001191089.1|refseq:NP_064511.2|refseq:NP_001191087.1|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1901726"(negative regulation of histone deacetylase activity)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2001169"(regulation of ATP biosynthetic process)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|reactome:R-HSA-1660661|ensembl:ENSG00000063176(gene)|ensembl:ENST00000245222(transcript)|ensembl:ENST00000598088(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0001568"(blood vessel development)|go:"GO:0001727"(lipid kinase activity)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006669"(sphinganine-1-phosphate biosynthetic process)|go:"GO:0006670"(sphingosine metabolic process)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008481"(sphinganine kinase activity)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0017050"(D-erythro-sphingosine kinase activity)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033008"(positive regulation of mast cell activation involved in immune response)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043977"(histone H2A-K5 acetylation)|go:"GO:0043980"(histone H2B-K12 acetylation)|go:"GO:0045815"(epigenetic maintenance of chromatin in transcription-competent conformation)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0007420"(brain development)	ensembl:ENSG00000115641(gene)|ensembl:ENST00000322142(transcript)|ensembl:ENST00000344213(transcript)|ensembl:ENST00000393352(transcript)|ensembl:ENST00000393353(transcript)|ensembl:ENST00000408995(transcript)|ensembl:ENST00000409177(transcript)|ensembl:ENST00000409807(transcript)|ensembl:ENST00000530340(transcript)|refseq:NP_001034581.1|refseq:NP_001441.4|refseq:NP_963849.1|refseq:NP_963851.2|refseq:NP_001305823.1|refseq:NP_001305824.1|refseq:NP_001305825.1|refseq:NP_001305826.1|refseq:XP_011509100.1|dip:DIP-5980N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|mint:Q14192|rcsb pdb:1X4K|rcsb pdb:1X4L|rcsb pdb:2D8Z|rcsb pdb:2MIU|reactome:R-HSA-1989781	-	-	-	figure legend:2 C|delivery method:Q14192; Q6X2Y2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/03/25	2014/10/16	rogid:aUEKsxWSpJaMjVKVLs4GsLYPkLI9606	rogid:4X5kI037ASzuT1zACXH89BkwDBk9606	intact-crc:6526A1F9B5232630|rigid:GfUO9ulOPfMH5cQczHtXuWA6OMI	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NYA1	uniprotkb:Q14192	intact:EBI-985303|uniprotkb:Q8N632|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726|uniprotkb:Q9HD92|uniprotkb:Q9NY70|uniprotkb:Q9NYL3|uniprotkb:Q96GK1	intact:EBI-701903|ensembl:ENSP00000322909|ensembl:ENSP00000344266|ensembl:ENSP00000377020|ensembl:ENSP00000377021|ensembl:ENSP00000386633|ensembl:ENSP00000386665|ensembl:ENSP00000386892|ensembl:ENSP00000433567|uniprotkb:Q13229|uniprotkb:Q13644|uniprotkb:Q9P294|uniprotkb:Q2I5I4|uniprotkb:Q5TM15	psi-mi:sphk1_human(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPK(gene name synonym)	psi-mi:fhl2_human(display_long)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)|uniprotkb:LIM domain protein DRAL(gene name synonym)|uniprotkb:FHL2(gene name)|psi-mi:FHL2(display_short)|uniprotkb:DRAL(gene name synonym)|uniprotkb:SLIM3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2006)	pubmed:16888242|imex:IM-20024	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1766608|imex:IM-20024-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001568"(blood vessel development)|go:"GO:0001727"(lipid kinase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006473"(protein acetylation)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0008289"(lipid binding)|go:"GO:0008481"(sphinganine kinase activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0017050"(D-erythro-sphingosine kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046521"(sphingoid catabolic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0098793"(presynapse)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1905364"(regulation of endosomal vesicle fusion)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|mint:Q9NYA1|rcsb pdb:3VZB|rcsb pdb:3VZC|rcsb pdb:3VZD|rcsb pdb:4L02|rcsb pdb:4V24|reactome:R-HSA-1660661|reactome:R-HSA-390471|reactome:R-HSA-5218921|reactome:R-HSA-9009391|refseq:XP_005257823.1|refseq:NP_001136073.1|refseq:NP_001136074.1|refseq:NP_068807.2|refseq:NP_892010.2	ensembl:ENSG00000115641(gene)|ensembl:ENST00000322142(transcript)|ensembl:ENST00000344213(transcript)|ensembl:ENST00000393352(transcript)|ensembl:ENST00000393353(transcript)|ensembl:ENST00000408995(transcript)|ensembl:ENST00000409177(transcript)|ensembl:ENST00000409807(transcript)|ensembl:ENST00000530340(transcript)|refseq:NP_001034581.1|refseq:NP_001441.4|refseq:NP_963849.1|refseq:NP_963851.2|refseq:NP_001305823.1|refseq:NP_001305824.1|refseq:NP_001305825.1|refseq:NP_001305826.1|refseq:XP_011509100.1|dip:DIP-5980N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|mint:Q14192|rcsb pdb:1X4K|rcsb pdb:1X4L|rcsb pdb:2D8Z|rcsb pdb:2MIU|reactome:R-HSA-1989781	-	-	-	figure legend:4|delivery method:Q14192; Q9NYA1 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/03/25	2014/10/16	rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606	rogid:4X5kI037ASzuT1zACXH89BkwDBk9606	intact-crc:A85316BCB7D301DA|rigid:92VCrKuTa+DsinqdQS2k7vh5VOY	false	flag tag:?-?|sufficient binding region:72-298	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O70433	uniprotkb:Q8CI15	intact:EBI-299379|ensembl:ENSMUSP00000008280|ensembl:ENSMUSP00000141170|uniprotkb:P97448	intact:EBI-985291|ensembl:ENSMUSP00000064743|ensembl:ENSMUSP00000067865|ensembl:ENSMUSP00000101994|ensembl:ENSMUSP00000101995|ensembl:ENSMUSP00000101996|uniprotkb:O88886|uniprotkb:Q91ZN3|uniprotkb:Q3U2E3	psi-mi:fhl2_mouse(display_long)|uniprotkb:Fhl2(gene name)|psi-mi:Fhl2(display_short)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)	psi-mi:sphk1_mouse(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:Sk1(gene name synonym)|uniprotkb:Sphk1(gene name)|psi-mi:Sphk1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sun et al. (2006)	pubmed:16888242|imex:IM-20024	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1748480|imex:IM-20024-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000008136(gene)|ensembl:ENSMUST00000008280(transcript)|ensembl:ENSMUST00000185893(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|refseq:NP_034342.1|refseq:XP_011236736.1|refseq:NP_001276462.1	go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090520"(sphingolipid mediated signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1905364"(regulation of endosomal vesicle fusion)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|reactome:R-MMU-1660661|reactome:R-MMU-390471|reactome:R-MMU-5218921|reactome:R-MMU-9009391|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSMUSG00000061878(gene)|ensembl:ENSMUST00000063396(transcript)|ensembl:ENSMUST00000063446(transcript)|ensembl:ENSMUST00000106386(transcript)|ensembl:ENSMUST00000106387(transcript)|ensembl:ENSMUST00000106388(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001568"(blood vessel development)|go:"GO:0001727"(lipid kinase activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003677"(DNA binding)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006473"(protein acetylation)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008481"(sphinganine kinase activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0017050"(D-erythro-sphingosine kinase activity)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|refseq:NP_001165943.1|refseq:NP_001165944.1|refseq:NP_001165946.1|refseq:NP_035581.1|refseq:NP_079643.2|ensembl:ENSMUSG00000061878|ensembl:ENSMUSG00000061878|ensembl:ENSMUSG00000061878|refseq:XP_006532733.1|refseq:XP_006532734.1|refseq:XP_006532735.1|refseq:XP_006532736.1	-	-	-	figure legend:2 D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-heart)|taxid:10090(Mus musculus heart [Cardiac; Cardiac tissue])	-	2008/03/25	2014/10/16	rogid:F/ksOc8Ay71/DwSdKCK0mehHCCs10090	rogid:pm15YvEtURHFTy+BFDNAE21/5rg10090	intact-crc:33976421B815F3B3|rigid:wcaC+CSMz2PYGDmal6gSxlVC5Pk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14192	uniprotkb:Q9NYA1	intact:EBI-701903|ensembl:ENSP00000322909|ensembl:ENSP00000344266|ensembl:ENSP00000377020|ensembl:ENSP00000377021|ensembl:ENSP00000386633|ensembl:ENSP00000386665|ensembl:ENSP00000386892|ensembl:ENSP00000433567|uniprotkb:Q13229|uniprotkb:Q13644|uniprotkb:Q9P294|uniprotkb:Q2I5I4|uniprotkb:Q5TM15	intact:EBI-985303|uniprotkb:Q8N632|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726|uniprotkb:Q9HD92|uniprotkb:Q9NY70|uniprotkb:Q9NYL3|uniprotkb:Q96GK1	psi-mi:fhl2_human(display_long)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)|uniprotkb:LIM domain protein DRAL(gene name synonym)|uniprotkb:FHL2(gene name)|psi-mi:FHL2(display_short)|uniprotkb:DRAL(gene name synonym)|uniprotkb:SLIM3(gene name synonym)	psi-mi:sphk1_human(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPK(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Sun et al. (2006)	pubmed:16888242|imex:IM-20024	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1748502|imex:IM-20024-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115641(gene)|ensembl:ENST00000322142(transcript)|ensembl:ENST00000344213(transcript)|ensembl:ENST00000393352(transcript)|ensembl:ENST00000393353(transcript)|ensembl:ENST00000408995(transcript)|ensembl:ENST00000409177(transcript)|ensembl:ENST00000409807(transcript)|ensembl:ENST00000530340(transcript)|refseq:NP_001034581.1|refseq:NP_001441.4|refseq:NP_963849.1|refseq:NP_963851.2|refseq:NP_001305823.1|refseq:NP_001305824.1|refseq:NP_001305825.1|refseq:NP_001305826.1|refseq:XP_011509100.1|dip:DIP-5980N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|mint:Q14192|rcsb pdb:1X4K|rcsb pdb:1X4L|rcsb pdb:2D8Z|rcsb pdb:2MIU|reactome:R-HSA-1989781	ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001568"(blood vessel development)|go:"GO:0001727"(lipid kinase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006473"(protein acetylation)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0008289"(lipid binding)|go:"GO:0008481"(sphinganine kinase activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0017050"(D-erythro-sphingosine kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046521"(sphingoid catabolic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0098793"(presynapse)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1905364"(regulation of endosomal vesicle fusion)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|mint:Q9NYA1|rcsb pdb:3VZB|rcsb pdb:3VZC|rcsb pdb:3VZD|rcsb pdb:4L02|rcsb pdb:4V24|reactome:R-HSA-1660661|reactome:R-HSA-390471|reactome:R-HSA-5218921|reactome:R-HSA-9009391|refseq:XP_005257823.1|refseq:NP_001136073.1|refseq:NP_001136074.1|refseq:NP_068807.2|refseq:NP_892010.2	-	-	-	figure legend:3 A|delivery method:Q14192; Q9NYA1 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/03/25	2014/10/16	rogid:4X5kI037ASzuT1zACXH89BkwDBk9606	rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606	intact-crc:73B76843F6A1E126|rigid:92VCrKuTa+DsinqdQS2k7vh5VOY	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:O35115	uniprotkb:Q91V26	intact:EBI-299316|ensembl:ENSRNOP00000023014	intact:EBI-1748634|uniprotkb:Q642F6	psi-mi:fhl2_rat(display_long)|uniprotkb:Fhl2(gene name)|psi-mi:Fhl2(display_short)|uniprotkb:Dral(gene name synonym)|uniprotkb:Slim3(gene name synonym)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)|uniprotkb:LIM domain protein DRAL(gene name synonym)	psi-mi:sphk1_rat(display_long)|uniprotkb:Sphk1(gene name)|psi-mi:Sphk1(display_short)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Sun et al. (2006)	pubmed:16888242|imex:IM-20024	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1748549|imex:IM-20024-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016866(gene)|ensembl:ENSRNOT00000023014(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|rgd:61963|refseq:NP_113865.1|refseq:XP_006244911.1|refseq:XP_017452106.1	rgd:620048|refseq:NP_596877.2|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001568"(blood vessel development)|go:"GO:0001727"(lipid kinase activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003677"(DNA binding)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006473"(protein acetylation)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|refseq:NP_001257736.1|refseq:NP_001257737.1|refseq:NP_001257738.1|refseq:NP_001257739.1|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|refseq:NP_001257740.1|reactome:R-RNO-1660661|reactome:R-RNO-390471|reactome:R-RNO-5218921|reactome:R-RNO-9009391|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008481"(sphinganine kinase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0017050"(D-erythro-sphingosine kinase activity)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032570"(response to progesterone)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0033198"(response to ATP)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090520"(sphingolipid mediated signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1905364"(regulation of endosomal vesicle fusion)	-	-	-	figure legend:3 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2008/03/25	2014/10/16	rogid:NJDAeuFd3QGH2gXXKuqXfwb+wMk10116	rogid:tWw+8kzySqU5jI9wP61J+Dcgzr810116	intact-crc:8AC811E8A562F088|rigid:VqHQPaaXu91eSBI5Xqi/y8RGB1w	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:O35115	uniprotkb:Q91V26	intact:EBI-299316|ensembl:ENSRNOP00000023014	intact:EBI-1748634|uniprotkb:Q642F6	psi-mi:fhl2_rat(display_long)|uniprotkb:Fhl2(gene name)|psi-mi:Fhl2(display_short)|uniprotkb:Dral(gene name synonym)|uniprotkb:Slim3(gene name synonym)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)|uniprotkb:LIM domain protein DRAL(gene name synonym)	psi-mi:sphk1_rat(display_long)|uniprotkb:Sphk1(gene name)|psi-mi:Sphk1(display_short)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sun et al. (2006)	pubmed:16888242|imex:IM-20024	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1748663|imex:IM-20024-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016866(gene)|ensembl:ENSRNOT00000023014(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|rgd:61963|refseq:NP_113865.1|refseq:XP_006244911.1|refseq:XP_017452106.1	rgd:620048|refseq:NP_596877.2|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001568"(blood vessel development)|go:"GO:0001727"(lipid kinase activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003677"(DNA binding)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006473"(protein acetylation)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|refseq:NP_001257736.1|refseq:NP_001257737.1|refseq:NP_001257738.1|refseq:NP_001257739.1|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|refseq:NP_001257740.1|reactome:R-RNO-1660661|reactome:R-RNO-390471|reactome:R-RNO-5218921|reactome:R-RNO-9009391|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008481"(sphinganine kinase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0017050"(D-erythro-sphingosine kinase activity)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032570"(response to progesterone)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0033198"(response to ATP)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090520"(sphingolipid mediated signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1905364"(regulation of endosomal vesicle fusion)	-	-	-	figure legend:6 A, 7 A|antagonist:"Endothelin-1 (ET-1) - Treatment with ET-1 (100 nmol/L, 30 minutes) decreased FHL2 interaction with SK1."|comment:siRNA against FHL2 reduced the amount of FHL2 coimmunoprecipitated with SK1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2008/03/25	2014/10/16	rogid:NJDAeuFd3QGH2gXXKuqXfwb+wMk10116	rogid:tWw+8kzySqU5jI9wP61J+Dcgzr810116	intact-crc:B85FF9D3A730CEA6|rigid:VqHQPaaXu91eSBI5Xqi/y8RGB1w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)