#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P20505 uniprotkb:P05412 intact:EBI-8568089|intact:MINT-6629100 intact:EBI-852823|uniprotkb:Q96G93|uniprotkb:Q6FHM7|ensembl:ENSP00000360266|ensembl:ENSP00000503132 psi-mi:b1_vaccc(display_long)|uniprotkb:VPK1(gene name)|psi-mi:VPK1(display_short)|uniprotkb:B1R(orf name)|uniprotkb:Vaccinia protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 1(gene name synonym) psi-mi:jun_human(display_long)|uniprotkb:JUN(gene name)|psi-mi:JUN(display_short)|uniprotkb:Activator protein 1(gene name synonym)|uniprotkb:Proto-oncogene c-Jun(gene name synonym)|uniprotkb:V-jun avian sarcoma virus 17 oncogene homolog(gene name synonym)|uniprotkb:p39(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Santos et al. (2006) pubmed:16840345|mint:MINT-6629273 taxid:10249(vaccc)|taxid:10249("Vaccinia virus (strain Copenhagen) (VACV)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8568107|mint:MINT-6629279 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005524"(ATP binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:P20505|mint:MINT-6629280(identity)|uniprotkb:P20505(P20505) refseq:NP_002219.1|ensembl:ENSP00000360266|ensembl:ENSP00000503132|dip:DIP-5961N|ensembl:ENSG00000177606(gene)|ensembl:ENST00000371222(transcript)|ensembl:ENST00000678696(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051365"(cellular response to potassium ion starvation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR002112(Transcription factor Jun)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR005643(Jun-like transcription factor)|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR015558(c-Jun Transcription Factor)|mint:P05412|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1JNM|rcsb pdb:1JUN|rcsb pdb:1S9K|rcsb pdb:1T2K|rcsb pdb:5FV8|rcsb pdb:5T01|rcsb pdb:6Y3V|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-5617472|reactome:R-HSA-5687128|reactome:R-HSA-6796648|reactome:R-HSA-8862803|reactome:R-HSA-8943724|reactome:R-HSA-9018519|reactome:R-HSA-9673324|mint:MINT-6629282(identity)|uniprotkb:P05412(P05412) - comment:mint|function:Essential serine/threonine-protein kinase. Required for viral replication - figure legend:F2B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/26 2014/10/16 rogid:V6EWYrc9ePZ/w5boT8/TwnOgBwY10249 rogid:zAVYwedHKKdvPPGttBP4XZkbCXA9606 intact-crc:47C281F3FF472120|rigid:qSCbuZO2quJbkc/JcAv5d0QhF+Y false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14733 uniprotkb:Q9UQF2 intact:EBI-492605|uniprotkb:O14648|uniprotkb:O14816|uniprotkb:O60452|uniprotkb:O60453|uniprotkb:Q1PG43|uniprotkb:Q8IY10|uniprotkb:B2R9S5|uniprotkb:D6W659|ensembl:ENSP00000381066 intact:EBI-78404|ensembl:ENSP00000241014|uniprotkb:O43407|uniprotkb:D3DQP4 psi-mi:mp2k7_human(display_long)|uniprotkb:MAPK/ERK kinase 7(gene name synonym)|uniprotkb:JNK-activating kinase 2(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 2(gene name synonym)|uniprotkb:MAP2K7(gene name)|psi-mi:MAP2K7(display_short)|uniprotkb:JNKK2(gene name synonym)|uniprotkb:MKK7(gene name synonym)|uniprotkb:PRKMK7(gene name synonym)|uniprotkb:MEK7(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 4(gene name synonym)|uniprotkb:SKK4(gene name synonym) psi-mi:jip1_human(display_long)|uniprotkb:MAPK8IP1(gene name)|psi-mi:MAPK8IP1(display_short)|uniprotkb:IB1(gene name synonym)|uniprotkb:JIP1(gene name synonym)|uniprotkb:PRKM8IP(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 1(gene name synonym)|uniprotkb:Islet-brain 1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Santos et al. (2006) pubmed:16840345|mint:MINT-6629273 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8568218|mint:MINT-6629296 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660186.1|ensembl:ENSG00000076984(gene)|ensembl:ENST00000397979(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009408"(response to heat)|go:"GO:0009411"(response to UV)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:O14733|rcsb pdb:2DYL|rcsb pdb:3WZU|rcsb pdb:4UX9|rcsb pdb:5B2K|rcsb pdb:5B2L|rcsb pdb:5B2M|rcsb pdb:5Y8U|rcsb pdb:5Y90|rcsb pdb:5Z1D|rcsb pdb:5Z1E|rcsb pdb:6IB0|rcsb pdb:6IB2|go:"GO:0000187"(obsolete activation of MAPK activity)|rcsb pdb:6QFL|rcsb pdb:6QFR|rcsb pdb:6QFT|rcsb pdb:6QG4|rcsb pdb:6QG7|rcsb pdb:6QHO|rcsb pdb:6QHR|rcsb pdb:6YFZ|rcsb pdb:6YG0|rcsb pdb:6YG1|rcsb pdb:6YG2|rcsb pdb:6YG3|rcsb pdb:6YG4|rcsb pdb:6YG5|rcsb pdb:6YG6|rcsb pdb:6YG7|rcsb pdb:6YZ4|rcsb pdb:7CBX|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-5210891|reactome:R-HSA-450321|refseq:NP_001284484.1|refseq:NP_001284485.1|mint:MINT-6629299(identity)|uniprotkb:O14733(O14733) ensembl:ENSG00000121653(gene)|ensembl:ENST00000241014(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044302"(dentate gyrus mossy fiber)|go:"GO:0045202"(synapse)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036028|mint:Q9UQF2|rcsb pdb:2G01|rcsb pdb:2GMX|rcsb pdb:2H96|rcsb pdb:3OXI|rcsb pdb:3PTG|rcsb pdb:3VUD|rcsb pdb:3VUG|rcsb pdb:3VUH|rcsb pdb:3VUI|rcsb pdb:3VUK|rcsb pdb:3VUL|rcsb pdb:3VUM|rcsb pdb:4E73|rcsb pdb:4G1W|rcsb pdb:4H39|rcsb pdb:4HYS|rcsb pdb:4HYU|rcsb pdb:4IZY|interpro:IPR035638|rcsb pdb:5LW1|rcsb pdb:6FUZ|refseq:NP_005447.1|mint:MINT-6629297(identity)|uniprotkb:Q9UQF2(Q9UQF2) - - - figure legend:F5B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-4(in vivo)|taxid:-4(in vivo) - 2008/06/26 2014/10/16 rogid:fEJqQ+bmZXzL9rSHk/Z01SQJFKM9606 rogid:16oAQc3NvvW+txnZndjUcFEl7ZQ9606 intact-crc:EFEBC75E3D5BD0F8|rigid:ki9ICT1ZeAt2gZdo6o05pZImnFA false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P20505 uniprotkb:Q9UQF2 intact:EBI-8568089|intact:MINT-6629100 intact:EBI-78404|ensembl:ENSP00000241014|uniprotkb:O43407|uniprotkb:D3DQP4 psi-mi:b1_vaccc(display_long)|uniprotkb:VPK1(gene name)|psi-mi:VPK1(display_short)|uniprotkb:B1R(orf name)|uniprotkb:Vaccinia protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 1(gene name synonym) psi-mi:jip1_human(display_long)|uniprotkb:MAPK8IP1(gene name)|psi-mi:MAPK8IP1(display_short)|uniprotkb:IB1(gene name synonym)|uniprotkb:JIP1(gene name synonym)|uniprotkb:PRKM8IP(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 1(gene name synonym)|uniprotkb:Islet-brain 1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Santos et al. (2006) pubmed:16840345|mint:MINT-6629273 taxid:10249(vaccc)|taxid:10249("Vaccinia virus (strain Copenhagen) (VACV)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8568176|mint:MINT-6629286 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005524"(ATP binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:P20505|mint:MINT-6629289(identity)|uniprotkb:P20505(P20505) ensembl:ENSG00000121653(gene)|ensembl:ENST00000241014(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044302"(dentate gyrus mossy fiber)|go:"GO:0045202"(synapse)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036028|mint:Q9UQF2|rcsb pdb:2G01|rcsb pdb:2GMX|rcsb pdb:2H96|rcsb pdb:3OXI|rcsb pdb:3PTG|rcsb pdb:3VUD|rcsb pdb:3VUG|rcsb pdb:3VUH|rcsb pdb:3VUI|rcsb pdb:3VUK|rcsb pdb:3VUL|rcsb pdb:3VUM|rcsb pdb:4E73|rcsb pdb:4G1W|rcsb pdb:4H39|rcsb pdb:4HYS|rcsb pdb:4HYU|rcsb pdb:4IZY|interpro:IPR035638|rcsb pdb:5LW1|rcsb pdb:6FUZ|refseq:NP_005447.1|mint:MINT-6629287(identity)|uniprotkb:Q9UQF2(Q9UQF2) - comment:mint|function:Essential serine/threonine-protein kinase. Required for viral replication - figure legend:F4 F5|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-4(in vivo)|taxid:-4(in vivo) - 2008/06/26 2014/10/16 rogid:V6EWYrc9ePZ/w5boT8/TwnOgBwY10249 rogid:16oAQc3NvvW+txnZndjUcFEl7ZQ9606 intact-crc:19454B8F12F1FFD2|rigid:6SsgsAzeg63VxU4dnuRxbx/QdxU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQF2 uniprotkb:O43318 intact:EBI-78404|ensembl:ENSP00000241014|uniprotkb:O43407|uniprotkb:D3DQP4 intact:EBI-358684|uniprotkb:O43317|uniprotkb:O43319|uniprotkb:Q9NZ70|uniprotkb:Q9NTR3|uniprotkb:E1P523|uniprotkb:Q5TDN2|uniprotkb:Q5TDN3|uniprotkb:B2RE27|uniprotkb:Q5TDT7|ensembl:ENSP00000358335 psi-mi:jip1_human(display_long)|uniprotkb:MAPK8IP1(gene name)|psi-mi:MAPK8IP1(display_short)|uniprotkb:IB1(gene name synonym)|uniprotkb:JIP1(gene name synonym)|uniprotkb:PRKM8IP(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 1(gene name synonym)|uniprotkb:Islet-brain 1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 1(gene name synonym) psi-mi:m3k7_human(display_long)|uniprotkb:MAP3K7(gene name)|psi-mi:MAP3K7(display_short)|uniprotkb:TAK1(gene name synonym)|uniprotkb:Transforming growth factor-beta-activated kinase 1(gene name synonym) psi-mi:"MI:0096"(pull down) Santos et al. (2006) pubmed:16840345|mint:MINT-6629273 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8568205|mint:MINT-6629291 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000121653(gene)|ensembl:ENST00000241014(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044302"(dentate gyrus mossy fiber)|go:"GO:0045202"(synapse)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036028|mint:Q9UQF2|rcsb pdb:2G01|rcsb pdb:2GMX|rcsb pdb:2H96|rcsb pdb:3OXI|rcsb pdb:3PTG|rcsb pdb:3VUD|rcsb pdb:3VUG|rcsb pdb:3VUH|rcsb pdb:3VUI|rcsb pdb:3VUK|rcsb pdb:3VUL|rcsb pdb:3VUM|rcsb pdb:4E73|rcsb pdb:4G1W|rcsb pdb:4H39|rcsb pdb:4HYS|rcsb pdb:4HYU|rcsb pdb:4IZY|interpro:IPR035638|rcsb pdb:5LW1|rcsb pdb:6FUZ|refseq:NP_005447.1|mint:MINT-6629292(identity)|uniprotkb:Q9UQF2(Q9UQF2) refseq:NP_003179.1|refseq:NP_663304.1|refseq:NP_663305.1|refseq:NP_663306.1|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|ensembl:ENSG00000135341(gene)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|ensembl:ENST00000369329(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017421(Mitogen-activated protein kinase kinase kinase 7)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43318|rcsb pdb:2EVA|rcsb pdb:2YIY|rcsb pdb:4GS6|rcsb pdb:4L3P|rcsb pdb:4L52|rcsb pdb:4L53|rcsb pdb:4O91|rcsb pdb:5E7R|rcsb pdb:5GJD|rcsb pdb:5GJF|rcsb pdb:5GJG|rcsb pdb:5J7S|rcsb pdb:5J8I|rcsb pdb:5J9L|rcsb pdb:5JGA|rcsb pdb:5JGB|rcsb pdb:5JGD|rcsb pdb:5JH6|rcsb pdb:5JK3|rcsb pdb:5V5N|rcsb pdb:7NTH|rcsb pdb:7NTI|reactome:R-HSA-1169091|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-4086398|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-5689880|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|dip:DIP-27523N|mint:MINT-6629294(identity)|uniprotkb:O43318(O43318) - - - figure legend:F5|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-4(in vivo)|taxid:-4(in vivo) - 2008/06/26 2014/10/16 rogid:16oAQc3NvvW+txnZndjUcFEl7ZQ9606 rogid:U/W3xH9XPl6BIdCcfrw1gG/+n7Y9606 intact-crc:6F287ABE07198096|rigid:FN0O2jqkCVSOcS+EfsNj2ZvGqcc false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQF2 uniprotkb:P45983 intact:EBI-78404|ensembl:ENSP00000241014|uniprotkb:O43407|uniprotkb:D3DQP4 intact:EBI-286483|uniprotkb:Q15709|uniprotkb:Q15712|uniprotkb:Q15713|uniprotkb:B7ZLV4|uniprotkb:B5BTZ5|uniprotkb:Q308M2|uniprotkb:D3DX88|uniprotkb:D3DX92|ensembl:ENSP00000363304 psi-mi:jip1_human(display_long)|uniprotkb:MAPK8IP1(gene name)|psi-mi:MAPK8IP1(display_short)|uniprotkb:IB1(gene name synonym)|uniprotkb:JIP1(gene name synonym)|uniprotkb:PRKM8IP(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 1(gene name synonym)|uniprotkb:Islet-brain 1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 1(gene name synonym) psi-mi:mk08_human(display_long)|uniprotkb:MAPK8(gene name)|psi-mi:MAPK8(display_short)|uniprotkb:JNK1(gene name synonym)|uniprotkb:PRKM8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:JNK-46(gene name synonym)|uniprotkb:SAPK1(gene name synonym)|uniprotkb:Stress-activated protein kinase 1c(gene name synonym)|uniprotkb:SAPK1C(gene name synonym) psi-mi:"MI:0096"(pull down) Santos et al. (2006) pubmed:16840345|mint:MINT-6629273 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8568251|mint:MINT-6629301 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000121653(gene)|ensembl:ENST00000241014(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044302"(dentate gyrus mossy fiber)|go:"GO:0045202"(synapse)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036028|mint:Q9UQF2|rcsb pdb:2G01|rcsb pdb:2GMX|rcsb pdb:2H96|rcsb pdb:3OXI|rcsb pdb:3PTG|rcsb pdb:3VUD|rcsb pdb:3VUG|rcsb pdb:3VUH|rcsb pdb:3VUI|rcsb pdb:3VUK|rcsb pdb:3VUL|rcsb pdb:3VUM|rcsb pdb:4E73|rcsb pdb:4G1W|rcsb pdb:4H39|rcsb pdb:4HYS|rcsb pdb:4HYU|rcsb pdb:4IZY|interpro:IPR035638|rcsb pdb:5LW1|rcsb pdb:6FUZ|refseq:NP_005447.1|mint:MINT-6629302(identity)|uniprotkb:Q9UQF2(Q9UQF2) refseq:NP_620634.1|refseq:NP_620637.1|refseq:NP_001310231.1|refseq:NP_001310250.1|refseq:NP_001310251.1|refseq:NP_001310252.1|refseq:NP_001310253.1|refseq:NP_001310254.1|refseq:NP_001310255.1|refseq:NP_001310256.1|refseq:NP_001310257.1|refseq:NP_001310258.1|refseq:NP_001310259.1|refseq:NP_001310260.1|refseq:NP_001265476.1|refseq:NP_001265477.1|dip:DIP-249N|ensembl:ENSG00000107643(gene)|ensembl:ENST00000374189(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031343"(positive regulation of cell killing)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0048511"(rhythmic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0090398"(cellular senescence)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1902595"(regulation of DNA replication origin binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:P45983|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:2G01|rcsb pdb:2GMX|rcsb pdb:2H96|rcsb pdb:2NO3|rcsb pdb:2XRW|rcsb pdb:2XS0|rcsb pdb:3ELJ|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3PZE|rcsb pdb:3V3V|rcsb pdb:3VUD|rcsb pdb:3VUG|rcsb pdb:3VUH|rcsb pdb:3VUI|rcsb pdb:3VUK|rcsb pdb:3VUL|rcsb pdb:3VUM|rcsb pdb:4AWI|rcsb pdb:4E73|rcsb pdb:4G1W|rcsb pdb:4HYS|rcsb pdb:4HYU|rcsb pdb:4IZY|rcsb pdb:4L7F|rcsb pdb:4QTD|rcsb pdb:4UX9|rcsb pdb:4YR8|rcsb pdb:5LW1|rcsb pdb:6F5E|rcsb pdb:6ZR5|reactome:R-HSA-111446|reactome:R-HSA-139910|reactome:R-HSA-193648|reactome:R-HSA-205043|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-450321|reactome:R-HSA-450341|reactome:R-HSA-5693565|reactome:R-HSA-9007892|reactome:R-HSA-9673324|mint:MINT-6629304(identity)|uniprotkb:P45983(P45983) - - - figure legend:F5C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-4(in vivo)|taxid:-4(in vivo) - 2008/06/26 2014/10/16 rogid:16oAQc3NvvW+txnZndjUcFEl7ZQ9606 rogid:8FsGgIJWzsgWymaBqL5+0eQ/7qM9606 intact-crc:95484576981CAFCF|rigid:JWEvByn0bhE+X+nbxGfK93kWMZg false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P20505 uniprotkb:O14733 intact:EBI-8568089|intact:MINT-6629100 intact:EBI-492605|uniprotkb:O14648|uniprotkb:O14816|uniprotkb:O60452|uniprotkb:O60453|uniprotkb:Q1PG43|uniprotkb:Q8IY10|uniprotkb:B2R9S5|uniprotkb:D6W659|ensembl:ENSP00000381066 psi-mi:b1_vaccc(display_long)|uniprotkb:VPK1(gene name)|psi-mi:VPK1(display_short)|uniprotkb:B1R(orf name)|uniprotkb:Vaccinia protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 1(gene name synonym) psi-mi:mp2k7_human(display_long)|uniprotkb:MAPK/ERK kinase 7(gene name synonym)|uniprotkb:JNK-activating kinase 2(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 2(gene name synonym)|uniprotkb:MAP2K7(gene name)|psi-mi:MAP2K7(display_short)|uniprotkb:JNKK2(gene name synonym)|uniprotkb:MKK7(gene name synonym)|uniprotkb:PRKMK7(gene name synonym)|uniprotkb:MEK7(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 4(gene name synonym)|uniprotkb:SKK4(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Santos et al. (2006) pubmed:16840345|mint:MINT-6629273 taxid:10249(vaccc)|taxid:10249("Vaccinia virus (strain Copenhagen) (VACV)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8568296|mint:MINT-6629308 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005524"(ATP binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:P20505|mint:MINT-6629311(identity)|uniprotkb:P20505(P20505) refseq:NP_660186.1|ensembl:ENSG00000076984(gene)|ensembl:ENST00000397979(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009408"(response to heat)|go:"GO:0009411"(response to UV)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:O14733|rcsb pdb:2DYL|rcsb pdb:3WZU|rcsb pdb:4UX9|rcsb pdb:5B2K|rcsb pdb:5B2L|rcsb pdb:5B2M|rcsb pdb:5Y8U|rcsb pdb:5Y90|rcsb pdb:5Z1D|rcsb pdb:5Z1E|rcsb pdb:6IB0|rcsb pdb:6IB2|go:"GO:0000187"(obsolete activation of MAPK activity)|rcsb pdb:6QFL|rcsb pdb:6QFR|rcsb pdb:6QFT|rcsb pdb:6QG4|rcsb pdb:6QG7|rcsb pdb:6QHO|rcsb pdb:6QHR|rcsb pdb:6YFZ|rcsb pdb:6YG0|rcsb pdb:6YG1|rcsb pdb:6YG2|rcsb pdb:6YG3|rcsb pdb:6YG4|rcsb pdb:6YG5|rcsb pdb:6YG6|rcsb pdb:6YG7|rcsb pdb:6YZ4|rcsb pdb:7CBX|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-5210891|reactome:R-HSA-450321|refseq:NP_001284484.1|refseq:NP_001284485.1|mint:MINT-6629309(identity)|uniprotkb:O14733(O14733) - comment:mint|function:Essential serine/threonine-protein kinase. Required for viral replication - figure legend:F5B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-4(in vivo)|taxid:-4(in vivo) - 2008/06/26 2014/10/16 rogid:V6EWYrc9ePZ/w5boT8/TwnOgBwY10249 rogid:fEJqQ+bmZXzL9rSHk/Z01SQJFKM9606 intact-crc:F1C268859898179D|rigid:2TTs4Wu0zz8XdKsD7O/MjRbS5Lk false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)