#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-1648113	uniprotkb:Q08050	ensembl:ENSG00000091831	intact:EBI-866480|uniprotkb:O43258|uniprotkb:O43259|uniprotkb:O43260|uniprotkb:Q4ZGG7|uniprotkb:Q9BRL2|ensembl:ENSP00000352901	psi-mi:s1s2_human_dna(display_short)|psi-mi:EBI-1648113(display_long)	psi-mi:foxm1_human(display_long)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Madureira et al. (2006)	pubmed:16809346|imex:IM-20019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1648115|imex:IM-20019-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_068772.2|refseq:NP_973731.1|refseq:NP_973732.1|refseq:NP_001230017.1|refseq:NP_001230018.1|dip:DIP-36754N|ensembl:ENSG00000111206(gene)|ensembl:ENST00000359843(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|interpro:IPR042839|rcsb pdb:3G73|reactome:R-HSA-156711|reactome:R-HSA-69273	-	-	-	figure legend:5 A|comment:The oligonucleotide was biotinylated.|inhibition:A non-biotinylated FHRE-containing oligonucleotide competed off FOXM1 binding to S1S2 in a concentration-dependent manner.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/19	2014/10/16	crc64:78116D3AB80D8EE1	rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606	intact-crc:2DF556F1B5D38AA6	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-1648131	uniprotkb:Q08050	ensembl:ENSG00000091831	intact:EBI-866480|uniprotkb:O43258|uniprotkb:O43259|uniprotkb:O43260|uniprotkb:Q4ZGG7|uniprotkb:Q9BRL2|ensembl:ENSP00000352901	psi-mi:s4_human_dna(display_short)|psi-mi:EBI-1648131(display_long)	psi-mi:foxm1_human(display_long)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Madureira et al. (2006)	pubmed:16809346|imex:IM-20019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1648133|imex:IM-20019-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_068772.2|refseq:NP_973731.1|refseq:NP_973732.1|refseq:NP_001230017.1|refseq:NP_001230018.1|dip:DIP-36754N|ensembl:ENSG00000111206(gene)|ensembl:ENST00000359843(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|interpro:IPR042839|rcsb pdb:3G73|reactome:R-HSA-156711|reactome:R-HSA-69273	-	-	-	figure legend:5 A|comment:The oligonucleotide was biotinylated.|inhibition:A non-biotinylated FHRE-containing oligonucleotide competed off FOXM1 binding to S4 in a concentration-dependent manner.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/19	2014/10/16	crc64:4B42C26A60DBE845	rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606	intact-crc:33E2BF254DF7DF3C	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08050	intact:EBI-1648139	intact:EBI-866480|uniprotkb:O43258|uniprotkb:O43259|uniprotkb:O43260|uniprotkb:Q4ZGG7|uniprotkb:Q9BRL2|ensembl:ENSP00000352901	ensembl:ENSG00000091831	psi-mi:foxm1_human(display_long)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym)	psi-mi:s6s7_human_dna(display_short)|psi-mi:EBI-1648139(display_long)	psi-mi:"MI:0096"(pull down)	Madureira et al. (2006)	pubmed:16809346|imex:IM-20019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1648141|imex:IM-20019-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	refseq:NP_068772.2|refseq:NP_973731.1|refseq:NP_973732.1|refseq:NP_001230017.1|refseq:NP_001230018.1|dip:DIP-36754N|ensembl:ENSG00000111206(gene)|ensembl:ENST00000359843(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|interpro:IPR042839|rcsb pdb:3G73|reactome:R-HSA-156711|reactome:R-HSA-69273	-	-	-	-	figure legend:5 A|comment:The oligonucleotide was biotinylated.|inhibition:A non-biotinylated FHRE-containing oligonucleotide competed off FOXM1 binding to S6S7 in a concentration-dependent manner.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/19	2014/10/16	rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606	crc64:AF75F8DA91FEE886	intact-crc:6A028D9AB5D38DA1	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-1648148	uniprotkb:Q08050	ensembl:ENSG00000091831	intact:EBI-866480|uniprotkb:O43258|uniprotkb:O43259|uniprotkb:O43260|uniprotkb:Q4ZGG7|uniprotkb:Q9BRL2|ensembl:ENSP00000352901	psi-mi:s8_human_dna(display_short)|psi-mi:EBI-1648148(display_long)	psi-mi:foxm1_human(display_long)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Madureira et al. (2006)	pubmed:16809346|imex:IM-20019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1648150|imex:IM-20019-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_068772.2|refseq:NP_973731.1|refseq:NP_973732.1|refseq:NP_001230017.1|refseq:NP_001230018.1|dip:DIP-36754N|ensembl:ENSG00000111206(gene)|ensembl:ENST00000359843(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|interpro:IPR042839|rcsb pdb:3G73|reactome:R-HSA-156711|reactome:R-HSA-69273	-	-	-	figure legend:5 A|comment:The oligonucleotide was biotinylated.|inhibition:A non-biotinylated FHRE-containing oligonucleotide competed off FOXM1 binding to S8 in a concentration-dependent manner.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/19	2014/10/16	crc64:16866C57B0AB043C	rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606	intact-crc:CF1EBF254DF7D4C8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43524	intact:EBI-1648113	intact:EBI-1644164|uniprotkb:Q9BZ04|uniprotkb:O15171|uniprotkb:Q5T2I7|uniprotkb:E1P5E6|uniprotkb:B4DVZ6|ensembl:ENSP00000339527|ensembl:ENSP00000385824	ensembl:ENSG00000091831	psi-mi:foxo3_human(display_long)|uniprotkb:FOXO3(gene name)|psi-mi:FOXO3(display_short)|uniprotkb:FKHRL1(gene name synonym)|uniprotkb:FOXO3A(gene name synonym)|uniprotkb:Forkhead in rhabdomyosarcoma-like 1(gene name synonym)|uniprotkb:AF6q21 protein(gene name synonym)	psi-mi:s1s2_human_dna(display_short)|psi-mi:EBI-1648113(display_long)	psi-mi:"MI:0096"(pull down)	Madureira et al. (2006)	pubmed:16809346|imex:IM-20019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1656233|imex:IM-20019-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	refseq:XP_011533930.1|refseq:XP_011533931.1|refseq:XP_005266925.1|refseq:NP_001446.1|refseq:NP_963853.1|refseq:XP_016866075.1|dip:DIP-29723N|ensembl:ENSG00000118689(gene)|ensembl:ENST00000343882(transcript)|ensembl:ENST00000406360(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2K86|rcsb pdb:2LQH|rcsb pdb:2LQI|rcsb pdb:2UZK|rcsb pdb:6MNL|reactome:R-HSA-1181150|reactome:R-HSA-198693|reactome:R-HSA-5674400|reactome:R-HSA-5687128|reactome:R-HSA-6785807|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9614657|reactome:R-HSA-9615017|reactome:R-HSA-9617629|reactome:R-HSA-9617828|reactome:R-HSA-9634638	-	-	crc64:E5B4E830665A9982	-	figure legend:5 A|comment:The oligonucleotide was biotinylated.|inhibition:A non-biotinylated FHRE-containing oligonucleotide competed off FOXO3 binding to S1S2 in a concentration-dependent manner.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/19	2014/10/16	rogid:kzNUkcFagA9f+Zhr7tZokroPzQQ9606	crc64:78116D3AB80D8EE1	intact-crc:4087FFA21B74E5FF	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43524	intact:EBI-1648131	intact:EBI-1644164|uniprotkb:Q9BZ04|uniprotkb:O15171|uniprotkb:Q5T2I7|uniprotkb:E1P5E6|uniprotkb:B4DVZ6|ensembl:ENSP00000339527|ensembl:ENSP00000385824	ensembl:ENSG00000091831	psi-mi:foxo3_human(display_long)|uniprotkb:FOXO3(gene name)|psi-mi:FOXO3(display_short)|uniprotkb:FKHRL1(gene name synonym)|uniprotkb:FOXO3A(gene name synonym)|uniprotkb:Forkhead in rhabdomyosarcoma-like 1(gene name synonym)|uniprotkb:AF6q21 protein(gene name synonym)	psi-mi:s4_human_dna(display_short)|psi-mi:EBI-1648131(display_long)	psi-mi:"MI:0096"(pull down)	Madureira et al. (2006)	pubmed:16809346|imex:IM-20019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1656348|imex:IM-20019-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	refseq:XP_011533930.1|refseq:XP_011533931.1|refseq:XP_005266925.1|refseq:NP_001446.1|refseq:NP_963853.1|refseq:XP_016866075.1|dip:DIP-29723N|ensembl:ENSG00000118689(gene)|ensembl:ENST00000343882(transcript)|ensembl:ENST00000406360(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2K86|rcsb pdb:2LQH|rcsb pdb:2LQI|rcsb pdb:2UZK|rcsb pdb:6MNL|reactome:R-HSA-1181150|reactome:R-HSA-198693|reactome:R-HSA-5674400|reactome:R-HSA-5687128|reactome:R-HSA-6785807|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9614657|reactome:R-HSA-9615017|reactome:R-HSA-9617629|reactome:R-HSA-9617828|reactome:R-HSA-9634638	-	-	crc64:E5B4E830665A9982	-	figure legend:5 A|comment:The oligonucleotide was biotinylated.|inhibition:A non-biotinylated FHRE-containing oligonucleotide competed off FOXO3 binding to S4 in a concentration-dependent manner.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/19	2014/10/16	rogid:kzNUkcFagA9f+Zhr7tZokroPzQQ9606	crc64:4B42C26A60DBE845	intact-crc:2AB1118222AE9EAD	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-1648139	uniprotkb:O43524	ensembl:ENSG00000091831	intact:EBI-1644164|uniprotkb:Q9BZ04|uniprotkb:O15171|uniprotkb:Q5T2I7|uniprotkb:E1P5E6|uniprotkb:B4DVZ6|ensembl:ENSP00000339527|ensembl:ENSP00000385824	psi-mi:s6s7_human_dna(display_short)|psi-mi:EBI-1648139(display_long)	psi-mi:foxo3_human(display_long)|uniprotkb:FOXO3(gene name)|psi-mi:FOXO3(display_short)|uniprotkb:FKHRL1(gene name synonym)|uniprotkb:FOXO3A(gene name synonym)|uniprotkb:Forkhead in rhabdomyosarcoma-like 1(gene name synonym)|uniprotkb:AF6q21 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Madureira et al. (2006)	pubmed:16809346|imex:IM-20019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1656456|imex:IM-20019-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011533930.1|refseq:XP_011533931.1|refseq:XP_005266925.1|refseq:NP_001446.1|refseq:NP_963853.1|refseq:XP_016866075.1|dip:DIP-29723N|ensembl:ENSG00000118689(gene)|ensembl:ENST00000343882(transcript)|ensembl:ENST00000406360(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2K86|rcsb pdb:2LQH|rcsb pdb:2LQI|rcsb pdb:2UZK|rcsb pdb:6MNL|reactome:R-HSA-1181150|reactome:R-HSA-198693|reactome:R-HSA-5674400|reactome:R-HSA-5687128|reactome:R-HSA-6785807|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9614657|reactome:R-HSA-9615017|reactome:R-HSA-9617629|reactome:R-HSA-9617828|reactome:R-HSA-9634638	-	-	crc64:E5B4E830665A9982	figure legend:5 A|comment:The oligonucleotide was biotinylated.|inhibition:A non-biotinylated FHRE-containing oligonucleotide competed off FOXO3 binding to S6S7 in a concentration-dependent manner.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/19	2014/10/16	crc64:AF75F8DA91FEE886	rogid:kzNUkcFagA9f+Zhr7tZokroPzQQ9606	intact-crc:077024C91B74E2F8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43524	intact:EBI-1648148	intact:EBI-1644164|uniprotkb:Q9BZ04|uniprotkb:O15171|uniprotkb:Q5T2I7|uniprotkb:E1P5E6|uniprotkb:B4DVZ6|ensembl:ENSP00000339527|ensembl:ENSP00000385824	ensembl:ENSG00000091831	psi-mi:foxo3_human(display_long)|uniprotkb:FOXO3(gene name)|psi-mi:FOXO3(display_short)|uniprotkb:FKHRL1(gene name synonym)|uniprotkb:FOXO3A(gene name synonym)|uniprotkb:Forkhead in rhabdomyosarcoma-like 1(gene name synonym)|uniprotkb:AF6q21 protein(gene name synonym)	psi-mi:s8_human_dna(display_short)|psi-mi:EBI-1648148(display_long)	psi-mi:"MI:0096"(pull down)	Madureira et al. (2006)	pubmed:16809346|imex:IM-20019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1656547|imex:IM-20019-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	refseq:XP_011533930.1|refseq:XP_011533931.1|refseq:XP_005266925.1|refseq:NP_001446.1|refseq:NP_963853.1|refseq:XP_016866075.1|dip:DIP-29723N|ensembl:ENSG00000118689(gene)|ensembl:ENST00000343882(transcript)|ensembl:ENST00000406360(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2K86|rcsb pdb:2LQH|rcsb pdb:2LQI|rcsb pdb:2UZK|rcsb pdb:6MNL|reactome:R-HSA-1181150|reactome:R-HSA-198693|reactome:R-HSA-5674400|reactome:R-HSA-5687128|reactome:R-HSA-6785807|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9614657|reactome:R-HSA-9615017|reactome:R-HSA-9617629|reactome:R-HSA-9617828|reactome:R-HSA-9634638	-	-	crc64:E5B4E830665A9982	-	figure legend:5 A|comment:The oligonucleotide was biotinylated.|inhibition:A non-biotinylated FHRE-containing oligonucleotide competed off FOXO3 binding to S8 in a concentration-dependent manner.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/19	2014/10/16	rogid:kzNUkcFagA9f+Zhr7tZokroPzQQ9606	crc64:16866C57B0AB043C	intact-crc:D64D118222AE9559	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43524	ensembl:ENSG00000091831	intact:EBI-1644164|uniprotkb:Q9BZ04|uniprotkb:O15171|uniprotkb:Q5T2I7|uniprotkb:E1P5E6|uniprotkb:B4DVZ6|ensembl:ENSP00000339527|ensembl:ENSP00000385824	intact:EBI-1657542	psi-mi:foxo3_human(display_long)|uniprotkb:FOXO3(gene name)|psi-mi:FOXO3(display_short)|uniprotkb:FKHRL1(gene name synonym)|uniprotkb:FOXO3A(gene name synonym)|uniprotkb:Forkhead in rhabdomyosarcoma-like 1(gene name synonym)|uniprotkb:AF6q21 protein(gene name synonym)	psi-mi:eralpha_human_gene(display_short)|psi-mi:ENSG00000091831(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Madureira et al. (2006)	pubmed:16809346|imex:IM-20019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1658723|imex:IM-20019-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:XP_011533930.1|refseq:XP_011533931.1|refseq:XP_005266925.1|refseq:NP_001446.1|refseq:NP_963853.1|refseq:XP_016866075.1|dip:DIP-29723N|ensembl:ENSG00000118689(gene)|ensembl:ENST00000343882(transcript)|ensembl:ENST00000406360(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2K86|rcsb pdb:2LQH|rcsb pdb:2LQI|rcsb pdb:2UZK|rcsb pdb:6MNL|reactome:R-HSA-1181150|reactome:R-HSA-198693|reactome:R-HSA-5674400|reactome:R-HSA-5687128|reactome:R-HSA-6785807|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9614657|reactome:R-HSA-9615017|reactome:R-HSA-9617629|reactome:R-HSA-9617828|reactome:R-HSA-9634638	-	-	crc64:E5B4E830665A9982	-	figure legend:5 B|comment:FOXO3 bound the region of the ERalpha promoter containing the S1/S2, S4 and S6/S7 FHREs.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2008/03/19	2014/10/16	rogid:kzNUkcFagA9f+Zhr7tZokroPzQQ9606	-	intact-crc:0C8C5219A42627B3	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:Q08050	ensembl:ENSG00000091831	intact:EBI-866480|uniprotkb:O43258|uniprotkb:O43259|uniprotkb:O43260|uniprotkb:Q4ZGG7|uniprotkb:Q9BRL2|ensembl:ENSP00000352901	intact:EBI-1657542	psi-mi:foxm1_human(display_long)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym)	psi-mi:eralpha_human_gene(display_short)|psi-mi:ENSG00000091831(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Madureira et al. (2006)	pubmed:16809346|imex:IM-20019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1658985|imex:IM-20019-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_068772.2|refseq:NP_973731.1|refseq:NP_973732.1|refseq:NP_001230017.1|refseq:NP_001230018.1|dip:DIP-36754N|ensembl:ENSG00000111206(gene)|ensembl:ENST00000359843(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|interpro:IPR042839|rcsb pdb:3G73|reactome:R-HSA-156711|reactome:R-HSA-69273	-	-	-	-	figure legend:5 B|comment:FOXM1 bound the region of the ERalpha promoter containing the S1/S2, S4 and S6/S7 FHREs.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2008/03/19	2014/10/16	rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606	-	intact-crc:2F02F998509EB5D1	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:O43524	uniprotkb:Q08050	intact:EBI-1644164|uniprotkb:Q9BZ04|uniprotkb:O15171|uniprotkb:Q5T2I7|uniprotkb:E1P5E6|uniprotkb:B4DVZ6|ensembl:ENSP00000339527|ensembl:ENSP00000385824	intact:EBI-866480|uniprotkb:O43258|uniprotkb:O43259|uniprotkb:O43260|uniprotkb:Q4ZGG7|uniprotkb:Q9BRL2|ensembl:ENSP00000352901	psi-mi:foxo3_human(display_long)|uniprotkb:FOXO3(gene name)|psi-mi:FOXO3(display_short)|uniprotkb:FKHRL1(gene name synonym)|uniprotkb:FOXO3A(gene name synonym)|uniprotkb:Forkhead in rhabdomyosarcoma-like 1(gene name synonym)|uniprotkb:AF6q21 protein(gene name synonym)	psi-mi:foxm1_human(display_long)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Madureira et al. (2006)	pubmed:16809346|imex:IM-20019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1659376|imex:IM-20019-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011533930.1|refseq:XP_011533931.1|refseq:XP_005266925.1|refseq:NP_001446.1|refseq:NP_963853.1|refseq:XP_016866075.1|dip:DIP-29723N|ensembl:ENSG00000118689(gene)|ensembl:ENST00000343882(transcript)|ensembl:ENST00000406360(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2K86|rcsb pdb:2LQH|rcsb pdb:2LQI|rcsb pdb:2UZK|rcsb pdb:6MNL|reactome:R-HSA-1181150|reactome:R-HSA-198693|reactome:R-HSA-5674400|reactome:R-HSA-5687128|reactome:R-HSA-6785807|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9614657|reactome:R-HSA-9615017|reactome:R-HSA-9617629|reactome:R-HSA-9617828|reactome:R-HSA-9634638	refseq:NP_068772.2|refseq:NP_973731.1|refseq:NP_973732.1|refseq:NP_001230017.1|refseq:NP_001230018.1|dip:DIP-36754N|ensembl:ENSG00000111206(gene)|ensembl:ENST00000359843(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|interpro:IPR042839|rcsb pdb:3G73|reactome:R-HSA-156711|reactome:R-HSA-69273	-	crc64:E5B4E830665A9982	-	figure legend:6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2008/03/19	2014/10/16	rogid:kzNUkcFagA9f+Zhr7tZokroPzQQ9606	rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606	intact-crc:E23B5D9E81FD45DD|rigid:5sz7SomqL+FCv4yvFqzq/0Qyidw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43524	uniprotkb:Q08050	intact:EBI-1644164|uniprotkb:Q9BZ04|uniprotkb:O15171|uniprotkb:Q5T2I7|uniprotkb:E1P5E6|uniprotkb:B4DVZ6|ensembl:ENSP00000339527|ensembl:ENSP00000385824	intact:EBI-866480|uniprotkb:O43258|uniprotkb:O43259|uniprotkb:O43260|uniprotkb:Q4ZGG7|uniprotkb:Q9BRL2|ensembl:ENSP00000352901	psi-mi:foxo3_human(display_long)|uniprotkb:FOXO3(gene name)|psi-mi:FOXO3(display_short)|uniprotkb:FKHRL1(gene name synonym)|uniprotkb:FOXO3A(gene name synonym)|uniprotkb:Forkhead in rhabdomyosarcoma-like 1(gene name synonym)|uniprotkb:AF6q21 protein(gene name synonym)	psi-mi:foxm1_human(display_long)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Madureira et al. (2006)	pubmed:16809346|imex:IM-20019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1660027|imex:IM-20019-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011533930.1|refseq:XP_011533931.1|refseq:XP_005266925.1|refseq:NP_001446.1|refseq:NP_963853.1|refseq:XP_016866075.1|dip:DIP-29723N|ensembl:ENSG00000118689(gene)|ensembl:ENST00000343882(transcript)|ensembl:ENST00000406360(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2K86|rcsb pdb:2LQH|rcsb pdb:2LQI|rcsb pdb:2UZK|rcsb pdb:6MNL|reactome:R-HSA-1181150|reactome:R-HSA-198693|reactome:R-HSA-5674400|reactome:R-HSA-5687128|reactome:R-HSA-6785807|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9614657|reactome:R-HSA-9615017|reactome:R-HSA-9617629|reactome:R-HSA-9617828|reactome:R-HSA-9634638	refseq:NP_068772.2|refseq:NP_973731.1|refseq:NP_973732.1|refseq:NP_001230017.1|refseq:NP_001230018.1|dip:DIP-36754N|ensembl:ENSG00000111206(gene)|ensembl:ENST00000359843(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|interpro:IPR042839|rcsb pdb:3G73|reactome:R-HSA-156711|reactome:R-HSA-69273	-	crc64:E5B4E830665A9982	-	figure legend:6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2008/03/19	2014/10/16	rogid:kzNUkcFagA9f+Zhr7tZokroPzQQ9606	rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606	intact-crc:F135DE4F764D0214|rigid:5sz7SomqL+FCv4yvFqzq/0Qyidw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)