#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P34144	uniprotkb:Q869N2	intact:EBI-1808643|uniprotkb:Q54YK6|uniprotkb:Q9GPU0|ensemblprotists:EAL68107	intact:EBI-2118601|uniprotkb:Q551M5|uniprotkb:O00911|uniprotkb:Q94488|ensemblprotists:EAL69183	psi-mi:rac1a_dicdi(display_long)|uniprotkb:rac1A(gene name)|psi-mi:rac1A(display_short)|uniprotkb:DDB_G0277869(orf name)	psi-mi:pakb_dicdi(display_long)|uniprotkb:pakB(gene name)|psi-mi:pakB(display_short)|uniprotkb:Ddpak(gene name synonym)|uniprotkb:mihck(gene name synonym)|uniprotkb:Myosin I heavy chain kinase(gene name synonym)|uniprotkb:DDB_G0276459(orf name)	psi-mi:"MI:0018"(two hybrid)	de et al. (2005)	pubmed:15509655|imex:IM-19293	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2118620|imex:IM-19293-1	author score:Strong	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0277869|ensemblprotists:DDB_G0277869(gene)|ensemblprotists:EAL68107(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005811"(lipid droplet)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031254"(cell trailing edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1904269"(cell leading edge cell cortex)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DDI-193648|reactome:R-DDI-2029482|reactome:R-DDI-389359|reactome:R-DDI-3928662|reactome:R-DDI-445144|reactome:R-DDI-5626467|reactome:R-DDI-5627123|reactome:R-DDI-5663213|reactome:R-DDI-5668599|reactome:R-DDI-5687128|reactome:R-DDI-6798695|reactome:R-DDI-9013149|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013418|reactome:R-DDI-9013420|reactome:R-DDI-9013422|reactome:R-DDI-9013424|reactome:R-DDI-9706019|reactome:R-DDI-983231|refseq:XP_642196.1	dictybase:DDB_G0276459|ensemblprotists:DDB_G0276459(gene)|ensemblprotists:EAL69183(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006907"(pinocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016020"(membrane)|go:"GO:0016905"(myosin heavy chain kinase activity)|go:"GO:0031152"(aggregation involved in sorocarp development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR033923|interpro:IPR036936|reactome:R-DDI-2029482|reactome:R-DDI-389359|reactome:R-DDI-3928662|reactome:R-DDI-445144|reactome:R-DDI-5621575|reactome:R-DDI-5627123|reactome:R-DDI-5687128|reactome:R-DDI-9013149|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013420|reactome:R-DDI-9013423|reactome:R-DDI-9013424|refseq:XP_643105.1	-	-	-	comment:Rac mutant was constitutively active|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/11/24	2014/10/16	rogid:kBmhXb5GJdKRREo3zRPPLA/xf2c44689	rogid:NzjRqM8XgAs5TBLIrw4YEZSuJLE44689	intact-crc:6A1424C9F648372A|rigid:CgrS0Z25vHdJbhF77VAqsMHkeRM	false	mutation:61-61	sufficient binding region:313-411(IPR000095)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P34145	uniprotkb:Q869N2	intact:EBI-2118631|uniprotkb:Q55EG7|uniprotkb:Q9GPT7|ensemblprotists:EAL72900	intact:EBI-2118601|uniprotkb:Q551M5|uniprotkb:O00911|uniprotkb:Q94488|ensemblprotists:EAL69183	psi-mi:rac1b_dicdi(display_long)|uniprotkb:rac1B(gene name)|psi-mi:rac1B(display_short)|uniprotkb:DDB_G0268622(orf name)	psi-mi:pakb_dicdi(display_long)|uniprotkb:pakB(gene name)|psi-mi:pakB(display_short)|uniprotkb:Ddpak(gene name synonym)|uniprotkb:mihck(gene name synonym)|uniprotkb:Myosin I heavy chain kinase(gene name synonym)|uniprotkb:DDB_G0276459(orf name)	psi-mi:"MI:0018"(two hybrid)	de et al. (2005)	pubmed:15509655|imex:IM-19293	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2118643|imex:IM-19293-2	author score:Strong	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0268622|ensemblprotists:DDB_G0268622(gene)|ensemblprotists:EAL72900(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031143"(pseudopodium)|go:"GO:0031152"(aggregation involved in sorocarp development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043326"(chemotaxis to folate)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:2000114"(regulation of establishment of cell polarity)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013418|reactome:R-DDI-9013420|reactome:R-DDI-9013422|reactome:R-DDI-9013424|reactome:R-DDI-9706019|refseq:XP_647053.2	dictybase:DDB_G0276459|ensemblprotists:DDB_G0276459(gene)|ensemblprotists:EAL69183(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006907"(pinocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016020"(membrane)|go:"GO:0016905"(myosin heavy chain kinase activity)|go:"GO:0031152"(aggregation involved in sorocarp development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR033923|interpro:IPR036936|reactome:R-DDI-2029482|reactome:R-DDI-389359|reactome:R-DDI-3928662|reactome:R-DDI-445144|reactome:R-DDI-5621575|reactome:R-DDI-5627123|reactome:R-DDI-5687128|reactome:R-DDI-9013149|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013420|reactome:R-DDI-9013423|reactome:R-DDI-9013424|refseq:XP_643105.1	-	-	-	comment:Rac mutant was constitutively active|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/11/24	2014/10/16	rogid:2czsgbovfbSBGEzWibVr8zdC7sY44689	rogid:NzjRqM8XgAs5TBLIrw4YEZSuJLE44689	intact-crc:AF8EB62AD1C4E9FF|rigid:lSzzURdzlbMjGcdyDdeys+V1H8k	false	mutation:12-12	sufficient binding region:313-411(IPR000095)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P34146	uniprotkb:Q869N2	intact:EBI-2118654|uniprotkb:Q54S70|uniprotkb:Q9U9S8|ensemblprotists:EAL66042	intact:EBI-2118601|uniprotkb:Q551M5|uniprotkb:O00911|uniprotkb:Q94488|ensemblprotists:EAL69183	psi-mi:rac1c_dicdi(display_long)|uniprotkb:rac1C(gene name)|psi-mi:rac1C(display_short)|uniprotkb:DDB_G0282365(orf name)	psi-mi:pakb_dicdi(display_long)|uniprotkb:pakB(gene name)|psi-mi:pakB(display_short)|uniprotkb:Ddpak(gene name synonym)|uniprotkb:mihck(gene name synonym)|uniprotkb:Myosin I heavy chain kinase(gene name synonym)|uniprotkb:DDB_G0276459(orf name)	psi-mi:"MI:0018"(two hybrid)	de et al. (2005)	pubmed:15509655|imex:IM-19293	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2118666|imex:IM-19293-3	author score:Strong	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0282365|ensemblprotists:DDB_G0282365(gene)|ensemblprotists:EAL66042(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013418|reactome:R-DDI-9013420|reactome:R-DDI-9013422|reactome:R-DDI-9013424|reactome:R-DDI-9706019|refseq:XP_640169.1	dictybase:DDB_G0276459|ensemblprotists:DDB_G0276459(gene)|ensemblprotists:EAL69183(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006907"(pinocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016020"(membrane)|go:"GO:0016905"(myosin heavy chain kinase activity)|go:"GO:0031152"(aggregation involved in sorocarp development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR033923|interpro:IPR036936|reactome:R-DDI-2029482|reactome:R-DDI-389359|reactome:R-DDI-3928662|reactome:R-DDI-445144|reactome:R-DDI-5621575|reactome:R-DDI-5627123|reactome:R-DDI-5687128|reactome:R-DDI-9013149|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013420|reactome:R-DDI-9013423|reactome:R-DDI-9013424|refseq:XP_643105.1	-	-	-	comment:Rac mutant was constitutively active|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/11/24	2014/10/16	rogid:vX3TlTA5/EIJKEHQWyzXZUbNu3Q44689	rogid:NzjRqM8XgAs5TBLIrw4YEZSuJLE44689	intact-crc:C3CC5B45DDF4F7A2|rigid:HUYwGlxZHvlvzodjeYwF1H75lYA	false	mutation:12-12	sufficient binding region:313-411(IPR000095)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P34147	uniprotkb:Q869N2	intact:EBI-2118677|uniprotkb:Q54LK0|uniprotkb:Q9GPT3|ensemblprotists:EAL64033	intact:EBI-2118601|uniprotkb:Q551M5|uniprotkb:O00911|uniprotkb:Q94488|ensemblprotists:EAL69183	psi-mi:raca_dicdi(display_long)|uniprotkb:racA(gene name)|psi-mi:racA(display_short)|uniprotkb:DDB_G0286555(orf name)	psi-mi:pakb_dicdi(display_long)|uniprotkb:pakB(gene name)|psi-mi:pakB(display_short)|uniprotkb:Ddpak(gene name synonym)|uniprotkb:mihck(gene name synonym)|uniprotkb:Myosin I heavy chain kinase(gene name synonym)|uniprotkb:DDB_G0276459(orf name)	psi-mi:"MI:0018"(two hybrid)	de et al. (2005)	pubmed:15509655|imex:IM-19293	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2118692|imex:IM-19293-4	author score:Strong	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0286555|ensemblprotists:DDB_G0286555(gene)|ensemblprotists:EAL64033(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027417|reactome:R-DDI-9013423|refseq:XP_637561.1	dictybase:DDB_G0276459|ensemblprotists:DDB_G0276459(gene)|ensemblprotists:EAL69183(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006907"(pinocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016020"(membrane)|go:"GO:0016905"(myosin heavy chain kinase activity)|go:"GO:0031152"(aggregation involved in sorocarp development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR033923|interpro:IPR036936|reactome:R-DDI-2029482|reactome:R-DDI-389359|reactome:R-DDI-3928662|reactome:R-DDI-445144|reactome:R-DDI-5621575|reactome:R-DDI-5627123|reactome:R-DDI-5687128|reactome:R-DDI-9013149|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013420|reactome:R-DDI-9013423|reactome:R-DDI-9013424|refseq:XP_643105.1	-	-	-	comment:Rac mutant was constitutively active|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/11/24	2014/10/16	rogid:CbY7Ooh3vPWTWnwMYMnxefBIDpY44689	rogid:NzjRqM8XgAs5TBLIrw4YEZSuJLE44689	intact-crc:77F20060D9E4FD96|rigid:nCBSM7JoZMnCJp6XQBwbmI0MHS0	false	mutation:12-12	sufficient binding region:313-411(IPR000095)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q869N2	uniprotkb:P34148	intact:EBI-2118601|uniprotkb:Q551M5|uniprotkb:O00911|uniprotkb:Q94488|ensemblprotists:EAL69183	intact:EBI-2118703|uniprotkb:Q54WH8|uniprotkb:Q9GPT2|ensemblprotists:EAL67577	psi-mi:pakb_dicdi(display_long)|uniprotkb:pakB(gene name)|psi-mi:pakB(display_short)|uniprotkb:Ddpak(gene name synonym)|uniprotkb:mihck(gene name synonym)|uniprotkb:Myosin I heavy chain kinase(gene name synonym)|uniprotkb:DDB_G0276459(orf name)	psi-mi:racb_dicdi(display_long)|uniprotkb:racB(gene name)|psi-mi:racB(display_short)|uniprotkb:DDB_G0279605(orf name)	psi-mi:"MI:0018"(two hybrid)	de et al. (2005)	pubmed:15509655|imex:IM-19293	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2118715|imex:IM-19293-5	author score:Strong	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0276459|ensemblprotists:DDB_G0276459(gene)|ensemblprotists:EAL69183(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006907"(pinocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016020"(membrane)|go:"GO:0016905"(myosin heavy chain kinase activity)|go:"GO:0031152"(aggregation involved in sorocarp development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR033923|interpro:IPR036936|reactome:R-DDI-2029482|reactome:R-DDI-389359|reactome:R-DDI-3928662|reactome:R-DDI-445144|reactome:R-DDI-5621575|reactome:R-DDI-5627123|reactome:R-DDI-5687128|reactome:R-DDI-9013149|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013420|reactome:R-DDI-9013423|reactome:R-DDI-9013424|refseq:XP_643105.1	dictybase:DDB_G0279605|ensemblprotists:DDB_G0279605(gene)|ensemblprotists:EAL67577(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006935"(chemotaxis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031152"(aggregation involved in sorocarp development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013418|reactome:R-DDI-9013420|reactome:R-DDI-9013422|reactome:R-DDI-9013424|reactome:R-DDI-9706019|refseq:XP_641575.1	-	-	-	comment:Rac mutant was constitutively active|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/11/24	2014/10/16	rogid:NzjRqM8XgAs5TBLIrw4YEZSuJLE44689	rogid:z3xJmClrU3ZnFULtb8To6FiXpJQ44689	intact-crc:1ABB58B3E5149ABE|rigid:YhNNgLEIbdH/IBEpD0XwceOHYmQ	false	sufficient binding region:313-411(IPR000095)	mutation:12-12	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P34149	uniprotkb:Q869N2	intact:EBI-2118726|uniprotkb:Q54BN9|ensemblprotists:EAL60575	intact:EBI-2118601|uniprotkb:Q551M5|uniprotkb:O00911|uniprotkb:Q94488|ensemblprotists:EAL69183	psi-mi:racc_dicdi(display_long)|uniprotkb:racC(gene name)|psi-mi:racC(display_short)|uniprotkb:DDB_G0293526(orf name)	psi-mi:pakb_dicdi(display_long)|uniprotkb:pakB(gene name)|psi-mi:pakB(display_short)|uniprotkb:Ddpak(gene name synonym)|uniprotkb:mihck(gene name synonym)|uniprotkb:Myosin I heavy chain kinase(gene name synonym)|uniprotkb:DDB_G0276459(orf name)	psi-mi:"MI:0018"(two hybrid)	de et al. (2005)	pubmed:15509655|imex:IM-19293	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2118737|imex:IM-19293-6	author score:Strong	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0293526|ensemblprotists:DDB_G0293526(gene)|ensemblprotists:EAL60575(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006935"(chemotaxis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1903669"(positive regulation of chemorepellent activity)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013418|reactome:R-DDI-9013420|reactome:R-DDI-9013422|reactome:R-DDI-9013424|reactome:R-DDI-9706019|refseq:XP_628990.1	dictybase:DDB_G0276459|ensemblprotists:DDB_G0276459(gene)|ensemblprotists:EAL69183(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006907"(pinocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016020"(membrane)|go:"GO:0016905"(myosin heavy chain kinase activity)|go:"GO:0031152"(aggregation involved in sorocarp development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR033923|interpro:IPR036936|reactome:R-DDI-2029482|reactome:R-DDI-389359|reactome:R-DDI-3928662|reactome:R-DDI-445144|reactome:R-DDI-5621575|reactome:R-DDI-5627123|reactome:R-DDI-5687128|reactome:R-DDI-9013149|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013420|reactome:R-DDI-9013423|reactome:R-DDI-9013424|refseq:XP_643105.1	-	-	-	comment:Rac mutant was constitutively active|figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/11/24	2014/10/16	rogid:42oGCZt+b9OZG5xwaYTlPVK9v5E44689	rogid:NzjRqM8XgAs5TBLIrw4YEZSuJLE44689	intact-crc:230B1171AF92C8A9|rigid:9ohA6HT9cq4XkxEn5jKGrBF630M	false	mutation:15-15	sufficient binding region:313-411(IPR000095)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q869N2	uniprotkb:Q23862	intact:EBI-2118601|uniprotkb:Q551M5|uniprotkb:O00911|uniprotkb:Q94488|ensemblprotists:EAL69183	intact:EBI-2118748|uniprotkb:Q54U41|ensemblprotists:EAL66784	psi-mi:pakb_dicdi(display_long)|uniprotkb:pakB(gene name)|psi-mi:pakB(display_short)|uniprotkb:Ddpak(gene name synonym)|uniprotkb:mihck(gene name synonym)|uniprotkb:Myosin I heavy chain kinase(gene name synonym)|uniprotkb:DDB_G0276459(orf name)	psi-mi:race_dicdi(display_long)|uniprotkb:racE(gene name)|psi-mi:racE(display_short)|uniprotkb:DDB_G0280975(orf name)	psi-mi:"MI:0018"(two hybrid)	de et al. (2005)	pubmed:15509655|imex:IM-19293	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2118759|imex:IM-19293-7	author score:Weak	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0276459|ensemblprotists:DDB_G0276459(gene)|ensemblprotists:EAL69183(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006907"(pinocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016020"(membrane)|go:"GO:0016905"(myosin heavy chain kinase activity)|go:"GO:0031152"(aggregation involved in sorocarp development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR033923|interpro:IPR036936|reactome:R-DDI-2029482|reactome:R-DDI-389359|reactome:R-DDI-3928662|reactome:R-DDI-445144|reactome:R-DDI-5621575|reactome:R-DDI-5627123|reactome:R-DDI-5687128|reactome:R-DDI-9013149|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013420|reactome:R-DDI-9013423|reactome:R-DDI-9013424|refseq:XP_643105.1	dictybase:DDB_G0280975|ensemblprotists:DDB_G0280975(gene)|ensemblprotists:EAL66784(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005811"(lipid droplet)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019954"(asexual reproduction)|go:"GO:0030587"(sorocarp development)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031254"(cell trailing edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043327"(chemotaxis to cAMP)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051291"(protein heterooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061118"(regulation of positive chemotaxis to cAMP)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:1904515"(positive regulation of TORC2 signaling)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0007015"(actin filament organization)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013418|reactome:R-DDI-9013420|reactome:R-DDI-9013422|reactome:R-DDI-9013424|reactome:R-DDI-9706019|refseq:XP_640935.1	-	-	-	comment:Rac mutant was constitutively active|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/11/24	2014/10/16	rogid:NzjRqM8XgAs5TBLIrw4YEZSuJLE44689	rogid:LWrI4jmYLba5/roU6sc20r1m0A044689	intact-crc:8AE2F2377AA9A011|rigid:41YQScC9fpxg95wuxwQNHICMMY4	false	sufficient binding region:313-411(IPR000095)	mutation:20-20	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O96390	uniprotkb:Q869N2	intact:EBI-2118770|uniprotkb:Q55DR0|ensemblprotists:EAL71938	intact:EBI-2118601|uniprotkb:Q551M5|uniprotkb:O00911|uniprotkb:Q94488|ensemblprotists:EAL69183	psi-mi:racf1_dicdi(display_long)|uniprotkb:racF1(gene name)|psi-mi:racF1(display_short)|uniprotkb:DDB_G0269176(orf name)	psi-mi:pakb_dicdi(display_long)|uniprotkb:pakB(gene name)|psi-mi:pakB(display_short)|uniprotkb:Ddpak(gene name synonym)|uniprotkb:mihck(gene name synonym)|uniprotkb:Myosin I heavy chain kinase(gene name synonym)|uniprotkb:DDB_G0276459(orf name)	psi-mi:"MI:0018"(two hybrid)	de et al. (2005)	pubmed:15509655|imex:IM-19293	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2118781|imex:IM-19293-8	author score:Strong	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0269176|ensemblprotists:DDB_G0269176(gene)|ensemblprotists:EAL71938(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044354"(macropinosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013418|reactome:R-DDI-9013420|reactome:R-DDI-9013422|reactome:R-DDI-9013424|reactome:R-DDI-9706019|refseq:XP_646071.1	dictybase:DDB_G0276459|ensemblprotists:DDB_G0276459(gene)|ensemblprotists:EAL69183(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006907"(pinocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016020"(membrane)|go:"GO:0016905"(myosin heavy chain kinase activity)|go:"GO:0031152"(aggregation involved in sorocarp development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR033923|interpro:IPR036936|reactome:R-DDI-2029482|reactome:R-DDI-389359|reactome:R-DDI-3928662|reactome:R-DDI-445144|reactome:R-DDI-5621575|reactome:R-DDI-5627123|reactome:R-DDI-5687128|reactome:R-DDI-9013149|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013420|reactome:R-DDI-9013423|reactome:R-DDI-9013424|refseq:XP_643105.1	-	-	-	comment:Rac mutant was constitutively active|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/11/24	2014/10/16	rogid:vSqeHTVXb5BSrknueW2g5lvswGY44689	rogid:NzjRqM8XgAs5TBLIrw4YEZSuJLE44689	intact-crc:BC32C89E437C9ACB|rigid:80ILwQ0ss5bRZQXvHURY/DQBm5A	false	mutation:12-12	sufficient binding region:313-411(IPR000095)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q869N2	uniprotkb:Q9GPS0	intact:EBI-2118601|uniprotkb:Q551M5|uniprotkb:O00911|uniprotkb:Q94488|ensemblprotists:EAL69183	intact:EBI-2118792|uniprotkb:Q55CY5|ensemblprotists:EAL71939	psi-mi:pakb_dicdi(display_long)|uniprotkb:pakB(gene name)|psi-mi:pakB(display_short)|uniprotkb:Ddpak(gene name synonym)|uniprotkb:mihck(gene name synonym)|uniprotkb:Myosin I heavy chain kinase(gene name synonym)|uniprotkb:DDB_G0276459(orf name)	psi-mi:racg_dicdi(display_long)|uniprotkb:DDB_G0269178(orf name)|uniprotkb:racG(gene name)|psi-mi:racG(display_short)	psi-mi:"MI:0018"(two hybrid)	de et al. (2005)	pubmed:15509655|imex:IM-19293	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2118803|imex:IM-19293-9	author score:Weak	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0276459|ensemblprotists:DDB_G0276459(gene)|ensemblprotists:EAL69183(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006907"(pinocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016020"(membrane)|go:"GO:0016905"(myosin heavy chain kinase activity)|go:"GO:0031152"(aggregation involved in sorocarp development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR033923|interpro:IPR036936|reactome:R-DDI-2029482|reactome:R-DDI-389359|reactome:R-DDI-3928662|reactome:R-DDI-445144|reactome:R-DDI-5621575|reactome:R-DDI-5627123|reactome:R-DDI-5687128|reactome:R-DDI-9013149|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013420|reactome:R-DDI-9013423|reactome:R-DDI-9013424|refseq:XP_643105.1	dictybase:DDB_G0269178|ensemblprotists:DDB_G0269178(gene)|ensemblprotists:EAL71939(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006909"(phagocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048870"(cell motility)|go:"GO:0097203"(phagocytic cup lip)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013418|reactome:R-DDI-9013420|reactome:R-DDI-9013422|reactome:R-DDI-9013424|reactome:R-DDI-9706019|refseq:XP_646346.1	-	-	-	comment:Rac mutant was constitutively active|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/11/24	2014/10/16	rogid:NzjRqM8XgAs5TBLIrw4YEZSuJLE44689	rogid:g58OZ32LXYOzemEY1gcFEhXKIo844689	intact-crc:DCDC15B421AE2D90|rigid:jSnkoZ5wBHpAEkg2W7rpTmhUo04	false	sufficient binding region:313-411(IPR000095)	mutation:12-12	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q869N2	uniprotkb:P63000	intact:EBI-2118601|uniprotkb:Q551M5|uniprotkb:O00911|uniprotkb:Q94488|ensemblprotists:EAL69183	intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4	psi-mi:pakb_dicdi(display_long)|uniprotkb:pakB(gene name)|psi-mi:pakB(display_short)|uniprotkb:Ddpak(gene name synonym)|uniprotkb:mihck(gene name synonym)|uniprotkb:Myosin I heavy chain kinase(gene name synonym)|uniprotkb:DDB_G0276459(orf name)	psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	de et al. (2005)	pubmed:15509655|imex:IM-19293	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2118817|imex:IM-19293-10	author score:Strong	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0276459|ensemblprotists:DDB_G0276459(gene)|ensemblprotists:EAL69183(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006907"(pinocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016020"(membrane)|go:"GO:0016905"(myosin heavy chain kinase activity)|go:"GO:0031152"(aggregation involved in sorocarp development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR033923|interpro:IPR036936|reactome:R-DDI-2029482|reactome:R-DDI-389359|reactome:R-DDI-3928662|reactome:R-DDI-445144|reactome:R-DDI-5621575|reactome:R-DDI-5627123|reactome:R-DDI-5687128|reactome:R-DDI-9013149|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013420|reactome:R-DDI-9013423|reactome:R-DDI-9013424|refseq:XP_643105.1	ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N	-	-	-	comment:Rac mutant was constitutively active|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/11/24	2014/10/16	rogid:NzjRqM8XgAs5TBLIrw4YEZSuJLE44689	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	intact-crc:E4CD496315E7438D|rigid:Mvli6T+DfS+gG52vwiLdjeBNie4	false	sufficient binding region:313-411(IPR000095)	mutation:12-12	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60953	uniprotkb:Q869N2	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	intact:EBI-2118601|uniprotkb:Q551M5|uniprotkb:O00911|uniprotkb:Q94488|ensemblprotists:EAL69183	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:pakb_dicdi(display_long)|uniprotkb:pakB(gene name)|psi-mi:pakB(display_short)|uniprotkb:Ddpak(gene name synonym)|uniprotkb:mihck(gene name synonym)|uniprotkb:Myosin I heavy chain kinase(gene name synonym)|uniprotkb:DDB_G0276459(orf name)	psi-mi:"MI:0018"(two hybrid)	de et al. (2005)	pubmed:15509655|imex:IM-19293	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2118828|imex:IM-19293-11	author score:Strong	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	dictybase:DDB_G0276459|ensemblprotists:DDB_G0276459(gene)|ensemblprotists:EAL69183(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006907"(pinocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016020"(membrane)|go:"GO:0016905"(myosin heavy chain kinase activity)|go:"GO:0031152"(aggregation involved in sorocarp development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR033923|interpro:IPR036936|reactome:R-DDI-2029482|reactome:R-DDI-389359|reactome:R-DDI-3928662|reactome:R-DDI-445144|reactome:R-DDI-5621575|reactome:R-DDI-5627123|reactome:R-DDI-5687128|reactome:R-DDI-9013149|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013420|reactome:R-DDI-9013423|reactome:R-DDI-9013424|refseq:XP_643105.1	-	-	-	comment:Rac mutant was constitutively active|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/11/24	2014/10/16	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	rogid:NzjRqM8XgAs5TBLIrw4YEZSuJLE44689	intact-crc:F62F5D6A37465C92|rigid:g7dWmqLq6M6UQfJs9J4EI901IC0	false	mutation:12-12	sufficient binding region:313-411(IPR000095)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)