#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q55GV3	uniprotkb:P34148	intact:EBI-2126912|uniprotkb:Q9NAY0	intact:EBI-2118703|uniprotkb:Q54WH8|uniprotkb:Q9GPT2|ensemblprotists:EAL67577	psi-mi:pakc_dicdi(display_long)|uniprotkb:pakC(gene name)|psi-mi:pakC(display_short)|uniprotkb:DDB_G0267450(orf name)	psi-mi:racb_dicdi(display_long)|uniprotkb:racB(gene name)|psi-mi:racB(display_short)|uniprotkb:DDB_G0279605(orf name)	psi-mi:"MI:0018"(two hybrid)	Lee et al. (2004)	pubmed:15483055|imex:IM-19187	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2126904|imex:IM-19187-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0267450|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031273"(negative regulation of pseudopodium assembly)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043327"(chemotaxis to cAMP)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033923|interpro:IPR036936|reactome:R-DDI-2029482|reactome:R-DDI-389359|reactome:R-DDI-3928662|reactome:R-DDI-445144|reactome:R-DDI-5621575|reactome:R-DDI-5627123|reactome:R-DDI-5687128|reactome:R-DDI-9013149|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013420|reactome:R-DDI-9013423|reactome:R-DDI-9013424|refseq:XP_647081.2	dictybase:DDB_G0279605|ensemblprotists:DDB_G0279605(gene)|ensemblprotists:EAL67577(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006935"(chemotaxis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031152"(aggregation involved in sorocarp development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013418|reactome:R-DDI-9013420|reactome:R-DDI-9013422|reactome:R-DDI-9013424|reactome:R-DDI-9706019|refseq:XP_641575.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/12/11	2014/10/16	rogid:PRpwWA1OrU+1DnlsY+JADUpNKjA44689	rogid:z3xJmClrU3ZnFULtb8To6FiXpJQ44689	intact-crc:6947B7D32E82A644|rigid:mLyW1M01FB4BWYF2DKVPoTxnC0I	false	sufficient binding region:110-147(IPR000095)	mutation:12-12|mutation decreasing interaction:17-17|mutation:61-61	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16152"	uniprotkb:Q55GV3	intact:EBI-2296297	intact:EBI-2126912|uniprotkb:Q9NAY0	psi-mi:1-phosphatidyl-1d-myo-inositol 3,4-bisphosphate(display_short)|psi-mi:"CHEBI:16152"(display_long)	psi-mi:pakc_dicdi(display_long)|uniprotkb:pakC(gene name)|psi-mi:pakC(display_short)|uniprotkb:DDB_G0267450(orf name)	psi-mi:"MI:0049"(filter binding)	Lee et al. (2004)	pubmed:15483055|imex:IM-19187	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2126957|imex:IM-19187-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	dictybase:DDB_G0267450|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031273"(negative regulation of pseudopodium assembly)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043327"(chemotaxis to cAMP)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033923|interpro:IPR036936|reactome:R-DDI-2029482|reactome:R-DDI-389359|reactome:R-DDI-3928662|reactome:R-DDI-445144|reactome:R-DDI-5621575|reactome:R-DDI-5627123|reactome:R-DDI-5687128|reactome:R-DDI-9013149|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013420|reactome:R-DDI-9013423|reactome:R-DDI-9013424|refseq:XP_647081.2	go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)	-	-	figure legend:"As illustrated in Figure 7A, the PAKc PH domain shows the strongest interaction with PI(3,4)P2"|figure legend:Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/12/11	2014/10/16	-	rogid:PRpwWA1OrU+1DnlsY+JADUpNKjA44689	intact-crc:FE9CD78E15C70F0B	false	-	glutathione s tranferase tag:?-?|32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
chebi:"CHEBI:16500"	uniprotkb:Q55GV3	intact:EBI-1257117	intact:EBI-2126912|uniprotkb:Q9NAY0	psi-mi:pi5p(display_short)|psi-mi:"CHEBI:16500"(display_long)	psi-mi:pakc_dicdi(display_long)|uniprotkb:pakC(gene name)|psi-mi:pakC(display_short)|uniprotkb:DDB_G0267450(orf name)	psi-mi:"MI:0049"(filter binding)	Lee et al. (2004)	pubmed:15483055|imex:IM-19187	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2127033|imex:IM-19187-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	dictybase:DDB_G0267450|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031273"(negative regulation of pseudopodium assembly)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043327"(chemotaxis to cAMP)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033923|interpro:IPR036936|reactome:R-DDI-2029482|reactome:R-DDI-389359|reactome:R-DDI-3928662|reactome:R-DDI-445144|reactome:R-DDI-5621575|reactome:R-DDI-5627123|reactome:R-DDI-5687128|reactome:R-DDI-9013149|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013420|reactome:R-DDI-9013423|reactome:R-DDI-9013424|refseq:XP_647081.2	go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)	-	-	figure legend:"As illustrated in Figure 7A, the PAKc PH domain shows the strongest interaction with PI(3,4)P2, a product of class I PI3Ks, and weaker interaction with PI(3)P and PI(5)P."|figure legend:Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/12/11	2014/10/16	-	rogid:PRpwWA1OrU+1DnlsY+JADUpNKjA44689	intact-crc:1E6E7EDF276317CE	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
chebi:"CHEBI:17283"	uniprotkb:Q55GV3	intact:EBI-1257113	intact:EBI-2126912|uniprotkb:Q9NAY0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pakc_dicdi(display_long)|uniprotkb:pakC(gene name)|psi-mi:pakC(display_short)|uniprotkb:DDB_G0267450(orf name)	psi-mi:"MI:0049"(filter binding)	Lee et al. (2004)	pubmed:15483055|imex:IM-19187	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2127052|imex:IM-19187-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	dictybase:DDB_G0267450|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031273"(negative regulation of pseudopodium assembly)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043327"(chemotaxis to cAMP)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033923|interpro:IPR036936|reactome:R-DDI-2029482|reactome:R-DDI-389359|reactome:R-DDI-3928662|reactome:R-DDI-445144|reactome:R-DDI-5621575|reactome:R-DDI-5627123|reactome:R-DDI-5687128|reactome:R-DDI-9013149|reactome:R-DDI-9013404|reactome:R-DDI-9013407|reactome:R-DDI-9013420|reactome:R-DDI-9013423|reactome:R-DDI-9013424|refseq:XP_647081.2	go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)	-	-	figure legend:"As illustrated in Figure 7A, the PAKc PH domain shows the strongest interaction with PI(3,4)P2, a product of class I PI3Ks, and weaker interaction with PI(3)P and PI(5)P."|figure legend:Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/12/11	2014/10/16	-	rogid:PRpwWA1OrU+1DnlsY+JADUpNKjA44689	intact-crc:112217785C838DFD	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)