#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O22476	uniprotkb:Q9LVM5	intact:EBI-1797828|uniprotkb:C0LGS4|ensemblplants:AT4G39400.1	intact:EBI-1803584|uniprotkb:Q2V2X6|uniprotkb:Q2V2X7|ensemblplants:AT5G58220.1	psi-mi:bri1_arath(display_long)|uniprotkb:Brassinosteroid LRR receptor kinase(gene name synonym)|uniprotkb:BRI1(gene name)|psi-mi:BRI1(display_short)|uniprotkb:F23K16.30(orf name)|uniprotkb:At4g39400(locus name)	psi-mi:tthl_arath(display_long)|uniprotkb:TTL(gene name)|psi-mi:TTL(display_short)|uniprotkb:Transthyretin-like protein(gene name synonym)|uniprotkb:MCK7.9(orf name)|uniprotkb:At5g58220(locus name)	psi-mi:"MI:0018"(two hybrid)	Nam et al. (2004)	pubmed:15319482	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1803613	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_195650.1|dip:DIP-45997N|ensemblplants:AT4G39400(gene)|ensemblplants:AT4G39400.1(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009729"(detection of brassinosteroid stimulus)|go:"GO:0009742"(brassinosteroid mediated signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009911"(positive regulation of flower development)|go:"GO:0010008"(endosome membrane)|go:"GO:0010224"(response to UV-B)|go:"GO:0010268"(brassinosteroid homeostasis)|go:"GO:0010584"(pollen exine formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048366"(leaf development)|go:"GO:0048657"(anther wall tapetum cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900140"(regulation of seedling development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013210(Leucine-rich repeat, N-terminal)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032675|rcsb pdb:3RGX|rcsb pdb:3RGZ|rcsb pdb:3RIZ|rcsb pdb:3RJ0|rcsb pdb:4LSA|rcsb pdb:4LSX|rcsb pdb:4M7E|rcsb pdb:4OH4|rcsb pdb:4Q5J|rcsb pdb:5LPB|rcsb pdb:5LPV|rcsb pdb:5LPW|rcsb pdb:5LPY|rcsb pdb:5LPZ|rcsb pdb:6FIF	refseq:NP_001032093.1|refseq:NP_001032094.1|refseq:NP_200630.1|interpro:IPR017129(Bifunctional hydroxyisourate hydrolase/2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase)|interpro:IPR014306(Hydroxyisourate hydrolase)|interpro:IPR018020|interpro:IPR023418|interpro:IPR000895(Transthyretin)|interpro:IPR023416|interpro:IPR023419|rcsb pdb:2Q37|interpro:IPR036778|interpro:IPR036817|ensemblplants:AT5G58220(gene)|ensemblplants:AT5G58220.1(transcript)|go:"GO:0001560"(regulation of cell growth by extracellular stimulus)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006144"(purine nucleobase metabolic process)|go:"GO:0009742"(brassinosteroid mediated signaling pathway)|go:"GO:0019428"(allantoin biosynthetic process)|go:"GO:0019628"(urate catabolic process)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033971"(hydroxyisourate hydrolase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051997"(2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity)	-	-	-	caution:"The range of the kinase domain used in the yeast two hybrid assay was not described in the text. The range is taken from Li and Chroy (1997) , PMID PMID: 9298904. Because the range is not directly taken from the source text, it is presented as a fuzzy range to indicate that the range was not explicitly stated by the authors of the paper under curation."	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/08/15	2014/10/16	rogid:nVBbwn3ENTpRurYSF4gjJbhJ/pE3702	rogid:ojCrSGoCp0wSr5/kYJJzRwWz+So3702	intact-crc:97A5F9F8D5795FF7|rigid:EMdr6j1Ahg8j01UoZf+elnRnzhc	false	sufficient binding region:883..883-1159..1159	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9LVM5	uniprotkb:O22476	intact:EBI-1803584|uniprotkb:Q2V2X6|uniprotkb:Q2V2X7|ensemblplants:AT5G58220.1	intact:EBI-1797828|uniprotkb:C0LGS4|ensemblplants:AT4G39400.1	psi-mi:tthl_arath(display_long)|uniprotkb:TTL(gene name)|psi-mi:TTL(display_short)|uniprotkb:Transthyretin-like protein(gene name synonym)|uniprotkb:MCK7.9(orf name)|uniprotkb:At5g58220(locus name)	psi-mi:bri1_arath(display_long)|uniprotkb:Brassinosteroid LRR receptor kinase(gene name synonym)|uniprotkb:BRI1(gene name)|psi-mi:BRI1(display_short)|uniprotkb:F23K16.30(orf name)|uniprotkb:At4g39400(locus name)	psi-mi:"MI:0018"(two hybrid)	Nam et al. (2004)	pubmed:15319482	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1803626	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001032093.1|refseq:NP_001032094.1|refseq:NP_200630.1|interpro:IPR017129(Bifunctional hydroxyisourate hydrolase/2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase)|interpro:IPR014306(Hydroxyisourate hydrolase)|interpro:IPR018020|interpro:IPR023418|interpro:IPR000895(Transthyretin)|interpro:IPR023416|interpro:IPR023419|rcsb pdb:2Q37|interpro:IPR036778|interpro:IPR036817|ensemblplants:AT5G58220(gene)|ensemblplants:AT5G58220.1(transcript)|go:"GO:0001560"(regulation of cell growth by extracellular stimulus)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006144"(purine nucleobase metabolic process)|go:"GO:0009742"(brassinosteroid mediated signaling pathway)|go:"GO:0019428"(allantoin biosynthetic process)|go:"GO:0019628"(urate catabolic process)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033971"(hydroxyisourate hydrolase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051997"(2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity)	refseq:NP_195650.1|dip:DIP-45997N|ensemblplants:AT4G39400(gene)|ensemblplants:AT4G39400.1(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009729"(detection of brassinosteroid stimulus)|go:"GO:0009742"(brassinosteroid mediated signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009911"(positive regulation of flower development)|go:"GO:0010008"(endosome membrane)|go:"GO:0010224"(response to UV-B)|go:"GO:0010268"(brassinosteroid homeostasis)|go:"GO:0010584"(pollen exine formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048366"(leaf development)|go:"GO:0048657"(anther wall tapetum cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900140"(regulation of seedling development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013210(Leucine-rich repeat, N-terminal)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032675|rcsb pdb:3RGX|rcsb pdb:3RGZ|rcsb pdb:3RIZ|rcsb pdb:3RJ0|rcsb pdb:4LSA|rcsb pdb:4LSX|rcsb pdb:4M7E|rcsb pdb:4OH4|rcsb pdb:4Q5J|rcsb pdb:5LPB|rcsb pdb:5LPV|rcsb pdb:5LPW|rcsb pdb:5LPY|rcsb pdb:5LPZ|rcsb pdb:6FIF	-	-	-	caution:"The range of the kinase domain used in the yeast two hybrid assay was not described in the text. The range is taken from Li and Chroy (1997) , PMID PMID: 9298904. Because the range is not directly taken from the source text, it is presented as a fuzzy range to indicate that the range was not explicitly stated by the authors of the paper under curation."|figure legend:Table 1 Figure 2B|comment:It should be noted that when the n-terminal 29 amino acid region of the TTL protein, demonstrated to be critical for interaction with BRL1, was fused to a protein which does not usually interact with BRL1; no interaction occurred. The authors concluded that other regions, besides the n-termianl region of the TTL protein, facilitated interaction with BRL1.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/08/15	2014/10/16	rogid:ojCrSGoCp0wSr5/kYJJzRwWz+So3702	rogid:nVBbwn3ENTpRurYSF4gjJbhJ/pE3702	intact-crc:88526F7D6E553B9B|rigid:EMdr6j1Ahg8j01UoZf+elnRnzhc	false	necessary binding region:1-29	sufficient binding region:883..883-1159..1159|mutation decreasing interaction:1048-1048|mutation decreasing interaction:1078-1078	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O22476	-	intact:EBI-1797828|uniprotkb:C0LGS4|ensemblplants:AT4G39400.1	-	psi-mi:bri1_arath(display_long)|uniprotkb:Brassinosteroid LRR receptor kinase(gene name synonym)|uniprotkb:BRI1(gene name)|psi-mi:BRI1(display_short)|uniprotkb:F23K16.30(orf name)|uniprotkb:At4g39400(locus name)	-	psi-mi:"MI:0424"(protein kinase assay)	Nam et al. (2004)	pubmed:15319482	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1803755	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_195650.1|dip:DIP-45997N|ensemblplants:AT4G39400(gene)|ensemblplants:AT4G39400.1(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009729"(detection of brassinosteroid stimulus)|go:"GO:0009742"(brassinosteroid mediated signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009911"(positive regulation of flower development)|go:"GO:0010008"(endosome membrane)|go:"GO:0010224"(response to UV-B)|go:"GO:0010268"(brassinosteroid homeostasis)|go:"GO:0010584"(pollen exine formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048366"(leaf development)|go:"GO:0048657"(anther wall tapetum cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900140"(regulation of seedling development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013210(Leucine-rich repeat, N-terminal)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032675|rcsb pdb:3RGX|rcsb pdb:3RGZ|rcsb pdb:3RIZ|rcsb pdb:3RJ0|rcsb pdb:4LSA|rcsb pdb:4LSX|rcsb pdb:4M7E|rcsb pdb:4OH4|rcsb pdb:4Q5J|rcsb pdb:5LPB|rcsb pdb:5LPV|rcsb pdb:5LPW|rcsb pdb:5LPY|rcsb pdb:5LPZ|rcsb pdb:6FIF	-	-	-	-	caution:"The range of the kinase domain used in the yeast two hybrid assay was not described in the text. The range is taken from Li and Chroy (1997) , PMID PMID: 9298904. Because the range is not directly taken from the source text, it is presented as a fuzzy range to indicate that the range was not explicitly stated by the authors of the paper under curation."|figure legend:Figure 2C|resulting-ptm:autophosphorylation of BRL1 protein	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/08/15	2014/10/16	rogid:nVBbwn3ENTpRurYSF4gjJbhJ/pE3702	-	intact-crc:91ED224E113BFC09	false	mutation decreasing interaction:1048-1048|sufficient binding region:883..883-1159..1159|mutation disrupting interaction:1078-1078|mutation decreasing interaction:1031-1031|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	-
uniprotkb:Q9LVM5	uniprotkb:O22476	intact:EBI-1803584|uniprotkb:Q2V2X6|uniprotkb:Q2V2X7|ensemblplants:AT5G58220.1	intact:EBI-1797828|uniprotkb:C0LGS4|ensemblplants:AT4G39400.1	psi-mi:tthl_arath(display_long)|uniprotkb:TTL(gene name)|psi-mi:TTL(display_short)|uniprotkb:Transthyretin-like protein(gene name synonym)|uniprotkb:MCK7.9(orf name)|uniprotkb:At5g58220(locus name)	psi-mi:bri1_arath(display_long)|uniprotkb:Brassinosteroid LRR receptor kinase(gene name synonym)|uniprotkb:BRI1(gene name)|psi-mi:BRI1(display_short)|uniprotkb:F23K16.30(orf name)|uniprotkb:At4g39400(locus name)	psi-mi:"MI:0424"(protein kinase assay)	Nam et al. (2004)	pubmed:15319482	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1803771	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001032093.1|refseq:NP_001032094.1|refseq:NP_200630.1|interpro:IPR017129(Bifunctional hydroxyisourate hydrolase/2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase)|interpro:IPR014306(Hydroxyisourate hydrolase)|interpro:IPR018020|interpro:IPR023418|interpro:IPR000895(Transthyretin)|interpro:IPR023416|interpro:IPR023419|rcsb pdb:2Q37|interpro:IPR036778|interpro:IPR036817|ensemblplants:AT5G58220(gene)|ensemblplants:AT5G58220.1(transcript)|go:"GO:0001560"(regulation of cell growth by extracellular stimulus)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006144"(purine nucleobase metabolic process)|go:"GO:0009742"(brassinosteroid mediated signaling pathway)|go:"GO:0019428"(allantoin biosynthetic process)|go:"GO:0019628"(urate catabolic process)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033971"(hydroxyisourate hydrolase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051997"(2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity)	refseq:NP_195650.1|dip:DIP-45997N|ensemblplants:AT4G39400(gene)|ensemblplants:AT4G39400.1(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009729"(detection of brassinosteroid stimulus)|go:"GO:0009742"(brassinosteroid mediated signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009911"(positive regulation of flower development)|go:"GO:0010008"(endosome membrane)|go:"GO:0010224"(response to UV-B)|go:"GO:0010268"(brassinosteroid homeostasis)|go:"GO:0010584"(pollen exine formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048366"(leaf development)|go:"GO:0048657"(anther wall tapetum cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900140"(regulation of seedling development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013210(Leucine-rich repeat, N-terminal)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032675|rcsb pdb:3RGX|rcsb pdb:3RGZ|rcsb pdb:3RIZ|rcsb pdb:3RJ0|rcsb pdb:4LSA|rcsb pdb:4LSX|rcsb pdb:4M7E|rcsb pdb:4OH4|rcsb pdb:4Q5J|rcsb pdb:5LPB|rcsb pdb:5LPV|rcsb pdb:5LPW|rcsb pdb:5LPY|rcsb pdb:5LPZ|rcsb pdb:6FIF	-	-	-	caution:"The range of the kinase domain used in the yeast two hybrid assay was not described in the text. The range is taken from Li and Chroy (1997) , PMID PMID: 9298904. Because the range is not directly taken from the source text, it is presented as a fuzzy range to indicate that the range was not explicitly stated by the authors of the paper under curation."|figure legend:Figure 2C|resulting-ptm:phosphorylation of TLL protein|resulting-ptm:autophosphorylation of BRL1 protein	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/08/15	2014/10/16	rogid:ojCrSGoCp0wSr5/kYJJzRwWz+So3702	rogid:nVBbwn3ENTpRurYSF4gjJbhJ/pE3702	intact-crc:673682458B2F6765|rigid:EMdr6j1Ahg8j01UoZf+elnRnzhc	false	maltose binding protein tag:?-?	glutathione s tranferase tag:?-?|mutation disrupting interaction:1078-1078|mutation disrupting interaction:1048-1048|mutation disrupting interaction:1031-1031|sufficient binding region:883..883-1159..1159	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)